Hub : Genes

PAFAH1B1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.17 0.043 1.4e-06 0.054 NA 0.038 NA 0.041 4.5e-06 NA 1.2e-04 NA 6.5e-05
2 ROSMAP Brain Pre-frontal Cortex 0.10 0.027 2.6e-06 0.033 0.060 0.064 0.063 0.063 4.1e-05 3.1e-08 1.1e-08 1.4e-08 1.4e-08
3 YFS Blood 0.13 0.023 0.0e+00 0.099 0.076 0.093 0.082 0.068 1.2e-30 1.4e-23 6.1e-29 1.8e-25 3.5e-21
4 TCGA Breast Normal 0.05 0.021 2.5e-03 0.003 0.008 0.017 NA 0.008 5.7e-02 3.1e-03 1.8e-05 NA 1.9e-03
5 TCGA Ovarian Tumor 0.15 0.058 6.4e-03 0.021 0.031 0.049 NA 0.044 3.1e-03 4.7e-04 1.1e-05 NA 3.4e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Alzheimer’s Disease (in mother) 0.5 0.6 2.6 -0.1 0.4 -0.3 0.4 -1.6
Alzheimer’s Disease (in father) 2.3 2.5 4.7 1.8 2.2 -1.7 0.3 -1.2
Alzheimer’s Disease (including proxy) 1.8 2.5 6.5 1.2 1.8 -1.0 0.5 -2.5
Crohns Disease (2017) 2.0 4.5 10.7 3.3 2.7 -1.7 1.3 -0.2
Irritable Bowel Disease (IBD) 1.3 3.2 10.2 3.2 1.9 -1.0 0.6 -0.9
Ulcerative Colitis (UC) 0.5 0.9 3.6 1.9 0.7 -0.4 -0.4 -0.5
Major Depression (MDD) 1.9 2.3 5.6 -1.3 -2.4 1.1 0.3 1.7
Reaction Time 0.5 0.9 3.8 -0.2 -0.4 1.9 -0.9 -0.1
Verbal and Numeric Reasoning (VNR) 0.4 0.9 3.5 0.7 -1.9 0.7 -0.1 0.2
Breast Cancer 2.0 4.9 10.1 1.7 2.0 -3.2 2.7 -0.5
Ovarian Cancer 1.4 1.9 6.2 -0.9 0.6 0.7 -1.2 2.5
Prostate Cancer 0.2 0.3 0.9 0.4 0.3 -0.9 0.5 0.6
Age at First Birth 1.1 1.6 3.2 1.7 1.8 -1.3 0.5 0.2
Bipolar Disorder 0.6 0.6 3.0 0.0 0.0 0.0 0.0 -1.7
Body Mass Index (BMI) (2010) 0.7 0.9 1.5 -1.2 -1.1 0.7 -0.2 1.2
Coronary Artery Disease (CAD) 2.0 2.4 6.1 -2.5 -2.2 0.2 0.0 0.9
Crohns Disease (2012) 1.0 1.7 3.1 -1.7 -1.8 1.5 -0.2 0.3
Mean Putamen Volume 2.8 3.3 5.4 -1.3 -2.0 1.9 -1.2 2.3
Fasting Glucose 0.7 0.9 3.1 -0.5 -0.2 0.9 -1.8 -0.4
HbA1C 0.2 0.2 0.7 -0.8 -0.3 -0.1 -0.4 0.0
HDL Cholesterol 0.5 0.8 1.7 1.2 0.3 -1.3 0.8 -0.5
LDL Cholesterol 0.5 0.7 1.5 0.4 -0.7 0.7 -1.0 1.2
Lupus 0.2 0.3 0.9 0.8 0.3 -0.1 -0.9 0.2
Neuroticism 2.1 3.1 14.5 -0.2 -0.1 -3.8 -0.4 -0.8
Primary Biliary Cirrhosis 0.8 1.1 2.0 -1.2 -1.4 0.6 -0.5 -1.3
Rheumatoid Arthritis 1.9 2.6 12.2 -0.4 0.5 0.4 -3.5 -0.1
Schizophrenia 0.6 1.2 3.3 1.0 -0.2 -1.8 1.2 -0.6
Triglycerides 0.3 0.4 1.1 -1.1 -0.7 0.1 -0.7 -0.2
Type 2 Diabetes (T2D) 1.7 2.0 3.3 -1.6 -1.7 1.0 -1.8 0.5
Ulcerative Colitis 1.5 2.2 3.3 -1.8 -1.7 1.7 0.6 1.3
Blood Eosinophil Count 0.6 4.8 8.6 -2.5 -2.1 1.7 -1.4 2.9
Blood Platelet Count 1.5 17.8 34.6 5.9 5.4 -3.6 0.1 -3.5
Blood Red Count 0.4 4.2 8.4 2.1 2.9 -1.1 1.1 -2.4
Blood White Count 0.5 3.8 11.7 1.6 3.4 -0.2 -1.9 -1.0
Heel T-Score 2.7 21.9 59.6 -4.3 -4.7 2.3 2.0 7.7
BMI 0.4 2.5 7.4 -2.7 -1.7 -1.0 -1.1 0.3
Height 0.2 4.5 16.3 0.3 0.9 4.0 -2.3 0.1
Waist Hip Ratio (WHR) 0.3 1.6 5.4 -2.3 -0.5 0.8 -0.1 -1.3
Systolic Blood Pressure 4.9 24.7 35.6 6.0 5.3 -5.8 2.1 -4.6
Smoking Status 2.3 5.5 14.3 -3.8 -1.7 -1.3 -1.3 2.6
Allergy or Eczema 0.2 0.6 1.9 -1.4 -0.6 -0.8 0.4 0.0
Cardiovascular Disease 0.4 1.2 2.5 -1.6 -1.2 -1.2 0.3 -0.8
Hypothyroidism (self reported) 0.3 0.7 1.1 1.0 0.6 -1.1 1.0 0.2
Respiratory disease 0.2 0.4 0.9 0.7 -0.4 -0.6 0.4 -0.9
Type 2 Diabetes (T2D) 0.4 0.7 1.2 -1.1 -0.9 0.6 0.8 0.5
Lung FEV1/FVC ratio 0.1 0.7 2.7 -0.9 -0.1 -0.1 -0.2 -1.6
Lung FVC 0.4 2.3 7.1 1.7 -0.7 0.9 -0.6 2.7
Neuroticism 3.9 9.7 27.8 2.0 2.1 -5.3 0.8 -3.4
Chronotype (morning person) 1.1 2.5 6.0 2.4 1.2 -0.4 -1.5 1.6
Hair Pigment 0.0 1.2 2.4 -1.5 -0.5 -0.0 1.5 1.0
Tanning 0.1 0.7 1.9 0.4 1.4 0.6 -1.0 0.1
Hand grip strength (left) 0.4 1.2 2.9 0.9 1.7 -1.3 -0.3 -0.7
Number of treatments/medications taken 0.7 1.3 3.0 0.1 0.3 1.2 -1.4 1.7
Average weekly spirits intake 1.0 1.3 5.6 0.2 0.2 0.0 2.4 0.7
Sensitivity / hurt feelings 1.7 3.0 10.3 -0.7 -1.2 3.2 -0.6 1.5
Frequency of depressed mood in last 2 weeks 2.7 3.8 15.8 0.3 -0.7 4.0 0.0 1.6
Hearing difficulty/problems: Yes 1.3 2.0 4.9 -0.8 -0.6 2.2 -1.7 1.3
Relative age of first facial hair 0.8 1.6 4.4 -0.9 -1.3 0.7 2.1 0.8
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 2.7 -1.1 -1.2 1.4 -0.9 1.6
Ever used hormone-replacement therapy (HRT) 1.9 2.4 4.8 -1.9 -2.2 1.8 0.0 0.4
Ever had hysterectomy (womb removed) 1.8 2.0 6.8 -1.2 -1.3 2.6 0.2 0.5
Systolic blood pressure, automated reading 5.4 16.0 23.5 -4.8 -4.7 4.4 -1.5 3.6
Eye problems/disorders: Diabetes related eye disease 3.5 3.8 8.0 2.1 2.8 -2.1 -0.8 -1.1
Angina 0.1 0.2 0.7 -0.2 0.9 0.2 -0.3 0.0
Medication for hormone replacement therapy 0.7 0.8 1.7 -1.3 -1.1 0.4 -0.4 -0.7
Vitamin and mineral supplements 1.1 1.6 7.1 0.5 0.4 -0.4 2.7 0.3
Supplements: Zinc 1.4 1.5 2.7 -1.6 -1.2 1.1 -0.8 1.2
Medication: Co-codamol 0.8 1.0 3.1 0.5 0.5 1.8 -0.3 1.0
Medication: Metformin 0.4 0.6 1.4 0.7 0.6 -0.7 -1.2 0.5
Diabetes (father) 1.2 1.5 3.4 -1.1 -1.3 1.9 0.7 0.9
Diabetes (mother) 1.1 1.4 3.8 -0.3 -1.3 -0.1 -1.3 1.9
Severe depression (siblings) 1.2 1.4 4.2 1.2 -0.5 2.0 -0.6 0.7
Pack years adult smoking proportion 1.9 3.0 5.6 -0.7 -2.0 2.4 1.9 1.0
Impedance of leg (right) 2.0 9.8 24.3 -4.9 -3.8 -0.1 0.6 3.1
Leg fat-free mass (left) 1.2 6.3 15.2 3.9 2.8 -1.2 0.9 -2.5
Trunk fat percentage 0.7 2.9 4.2 -1.2 -1.3 1.9 2.0 1.8
Hand grip strength (right) 0.1 0.3 0.7 0.3 0.7 0.1 -0.3 -0.8
Townsend deprivation index at recruitment 0.9 1.2 3.8 0.2 -1.2 2.0 0.1 0.9
Current tobacco smoking 0.8 1.3 3.9 1.2 -1.0 2.0 0.4 0.2
Average weekly fortified wine intake 2.7 3.2 5.7 0.8 1.7 -2.3 2.4 -1.2
Maternal smoking around birth 0.6 0.8 3.5 0.5 -0.3 0.3 0.4 -1.9
Fed-up feelings 2.8 5.2 17.0 0.7 -0.2 4.1 -1.3 2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 5.3 0.9 0.7 2.3 0.2 0.3
Relative age voice broke 1.2 1.9 5.7 0.3 -0.5 -1.1 2.4 1.6
Taking other prescription medications 1.6 2.4 6.4 -0.7 0.3 2.5 -1.9 1.3
Age when periods started (menarche) 0.1 0.2 0.4 -0.1 0.5 -0.6 0.6 -0.2
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.0 -0.5 -1.4 0.8 0.5 0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.7 3.8 9.0 1.3 2.1 1.0 -1.7 -3.0
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 3.4 1.6 1.8 -1.3 -1.2 -0.6
Qualifications: CSEs or equivalent 0.8 1.1 2.3 0.1 -0.2 1.0 1.4 -1.5
Serious illness, injury or assault to yourself 0.4 0.5 1.2 -0.2 0.1 -0.8 1.1 0.6
High blood pressure 0.2 0.7 1.5 0.4 0.1 0.9 -1.0 1.2
Hayfever, allergic rhinitis or eczema 0.4 0.9 1.6 1.0 0.7 1.0 -1.2 -0.5
Multivitamins +/- minerals 1.2 1.5 6.6 -0.1 -0.8 -0.4 -2.6 -0.3
Stomach or abdominal pain in last month 2.5 3.1 6.3 1.8 0.6 2.4 0.1 2.5
Supplements: Glucosamine 0.4 0.5 1.2 0.2 0.4 -1.0 -0.4 -1.1
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.1 -1.0 -0.6 0.7 -0.7 0.4
Medication: Atenolol 0.4 0.5 1.1 1.1 0.5 0.5 -0.7 -0.8
Medication: Levothyroxine sodium 0.4 0.8 3.7 -0.2 -0.2 0.1 -1.9 -0.0
Sitting height 0.4 3.2 8.4 -0.1 0.3 -2.9 0.6 -2.7
Chronic bronchitis/emphysema (father) 0.6 0.7 1.7 1.2 0.2 -0.1 1.3 0.4
High blood pressure (mother) 0.6 0.8 3.3 -0.2 -0.1 0.6 -1.8 0.4
Body mass index (BMI) 0.5 2.2 6.0 1.7 0.8 2.4 1.1 -0.6
Impedance of leg (left) 2.3 11.4 27.0 -5.2 -4.2 0.4 0.7 3.4
Leg predicted mass (left) 1.2 6.3 14.9 3.9 2.8 -1.2 0.9 -2.5
Trunk fat mass 0.3 1.2 2.7 -0.1 -0.7 1.4 1.6 1.0
Waist circumference 0.4 1.5 3.6 1.4 0.1 1.9 0.7 1.2
Number of incorrect matches in round 1.6 2.7 6.1 -1.8 -1.6 1.3 0.3 2.5
Past tobacco smoking 2.2 4.2 13.2 -3.6 -2.3 0.1 -0.1 1.6
Alcohol usually taken with meals 0.8 1.3 2.5 1.6 0.6 -1.3 -1.2 -0.7
Nervous feelings 2.7 5.2 12.7 -1.7 -1.0 3.0 -0.2 3.6
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.4 5.9 1.4 1.6 2.4 -0.9 0.9
Hearing difficulty/problems with background noise 2.6 4.1 17.9 1.2 -0.3 4.2 -0.7 0.8
Hair/balding pattern: Pattern 2 0.4 0.5 2.0 -1.4 -0.4 0.2 -0.6 -0.4
Had menopause 1.2 1.5 2.5 -1.1 -1.1 1.5 -0.4 1.6
Had other major operations 0.3 0.4 1.1 0.6 -0.3 0.4 -1.1 -0.2
Forced vital capacity (FVC) 1.0 4.0 9.5 -0.0 1.0 -3.0 0.3 -3.1
Heel bone mineral density (BMD) T-score, automated (right) 1.6 3.6 9.7 0.7 1.7 1.5 -1.6 -3.1
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 2.4 0.1 1.5 1.0 -1.3 1.4
Qualifications: None of the above 0.7 1.4 2.9 -0.9 -1.4 1.7 0.9 0.9
Financial difficulties in last 2 years 0.9 1.3 3.0 0.5 0.5 1.7 0.5 1.6
Mouth/teeth dental problems 0.8 1.2 3.0 -1.7 0.5 -0.2 0.4 -1.5
Heart attack 1.4 1.8 3.9 2.0 1.9 -1.3 0.3 -0.3
Allergy 0.4 1.0 2.2 -1.4 -1.5 -0.2 1.0 0.2
Pain all over the body in last month 1.5 1.6 3.3 -1.8 -1.3 1.0 -0.7 1.2
Diabetes (self-reported) 0.6 1.0 2.3 1.2 1.5 -0.3 -1.0 0.4
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.7 -0.6 -1.0 1.6 -1.4 0.2
Medication: Ramipril 0.9 1.2 3.1 1.1 0.8 0.5 -1.7 -0.7
Medication: Simvastatin 0.4 0.6 1.7 -0.4 0.2 1.3 -0.4 0.8
Fluid intelligence score 0.3 0.6 1.5 -1.2 1.0 -0.1 -0.4 -0.8
Illnesses of siblings 1.2 1.7 6.0 -1.2 -0.1 -0.5 2.4 0.9
Neuroticism score 4.6 9.8 27.1 -1.3 -2.1 5.2 -1.6 3.6
Weight 0.3 1.3 3.5 1.9 0.8 0.5 1.2 -1.0
Impedance of arm (right) 1.7 8.1 22.1 -4.7 -2.6 -0.3 0.3 3.4
Arm fat percentage (right) 0.5 2.2 5.8 -0.3 -0.7 2.4 1.4 1.5
Trunk fat-free mass 1.1 6.3 14.4 3.8 2.2 -2.1 -0.2 -2.8
Hip circumference 0.2 0.9 3.6 -0.1 0.2 1.9 0.7 0.5
Time employed in main current job 0.7 0.8 1.9 -1.4 -0.0 -1.3 -0.5 -0.3
Alcohol intake versus 10 years previously 1.8 2.8 4.6 1.4 2.0 -0.7 1.7 -2.2
Father’s age at death 2.3 3.1 8.4 -1.4 -2.9 0.9 -1.9 0.8
Worrier / anxious feelings 1.9 3.6 8.5 -0.3 -0.6 2.8 -1.0 2.9
Frequency of tiredness / lethargy in last 2 weeks 4.6 7.5 33.5 0.5 -0.4 5.8 -0.7 1.8
Falls in the last year 0.1 0.1 0.2 0.2 0.3 -0.3 -0.5 -0.3
Hair/balding pattern: Pattern 3 0.8 1.2 2.9 -1.0 -1.7 0.9 -0.5 0.9
Number of live births 0.8 1.1 2.2 1.5 1.5 -0.2 0.5 0.8
Forced expiratory volume in 1-second (FEV1) 0.7 2.6 8.2 -0.2 0.6 -2.1 -0.3 -2.9
Pulse rate 1.1 1.8 2.8 -1.1 -1.6 1.7 0.3 1.5
Happiness 1.2 1.4 3.1 1.3 0.7 1.4 -0.2 1.8
Noisy workplace 0.5 0.6 1.2 -0.5 -1.1 0.8 -1.0 0.2
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.2 -1.1 -0.8 0.6 -1.0 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.9 0.4 0.0 0.2 -0.9 0.6
Mouth/teeth dental problems: Dentures 0.9 1.6 3.6 1.5 -1.0 -0.6 0.8 1.9
Asthma 0.5 0.9 1.8 0.7 1.3 -1.0 -0.4 1.0
Medication: Ibuprofen (e.g. Nurofen) 2.3 3.0 8.0 -1.2 -1.1 0.2 -2.8 2.0
Medication: Cholesterol lowering 0.2 0.3 1.4 -0.2 1.2 -0.3 0.2 0.1
Depression (self-reported) 0.7 0.8 1.7 0.9 1.3 0.2 -0.0 1.2
Medication: Lansoprazole 0.8 0.9 1.5 1.2 0.6 -0.8 0.8 1.2
Prospective memory result 0.8 1.0 2.4 0.9 -1.2 -0.1 1.5 0.7
Lung cancer (father) 2.0 2.3 3.8 1.6 0.6 -1.6 1.9 -1.6
Illnesses of mother 1.1 1.4 5.0 0.5 0.6 1.1 0.5 -2.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 5.3 -0.2 0.4 -1.7 -0.2 -2.3
Pulse wave Arterial Stiffness index 0.7 0.8 1.6 0.1 -1.0 0.2 1.1 1.2
Impedance of arm (left) 1.3 6.1 16.5 -4.1 -1.9 -1.0 0.8 2.9
Arm fat mass (right) 0.3 1.2 3.2 0.8 0.1 1.8 1.4 0.2
Trunk predicted mass 1.1 6.1 13.4 3.7 2.2 -2.2 -0.2 -2.8
Standing height 0.4 3.6 15.9 0.7 0.3 -4.0 0.5 -1.1
Length of working week for main job 1.3 1.4 2.9 0.8 1.7 -0.3 1.1 -1.5
Exposure to tobacco smoke at home 0.8 0.9 3.1 -0.6 0.4 -0.7 -0.6 -1.8
Breastfed as a baby 0.5 0.6 1.2 1.0 1.1 -0.7 -0.3 -0.2
Tense / ‘highly strung’ 0.7 1.2 4.1 -0.5 -0.3 1.1 0.3 2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.1 7.5 2.7 1.5 -0.2 -0.2 0.7
Hair/balding pattern: Pattern 4 0.7 1.8 5.2 -1.5 0.8 0.1 -0.8 2.3
Birth weight of first child 4.0 7.3 16.4 -1.3 -2.1 4.0 0.9 3.6
Peak expiratory flow (PEF) 0.9 2.0 4.8 -2.2 -1.3 0.4 -1.7 -0.9
Pulse wave reflection index 0.8 1.0 1.6 -1.2 -1.3 0.4 1.1 0.8
Ever highly irritable/argumentative for 2 days 0.8 0.9 2.2 1.0 0.8 -0.1 -1.5 0.9
Loud music exposure frequency 1.1 1.2 3.7 -0.2 -1.1 1.9 0.9 -0.4
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.4 -1.6 -0.8 0.4 -1.1 0.4
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.5 0.2 0.3 -0.3 -0.7 -0.7
Blood clot in the leg (DVT) 0.4 0.5 1.0 0.7 1.0 -1.0 -0.4 -0.3
Medication: Paracetamol 0.8 1.4 3.0 -0.8 -1.2 1.7 -1.0 0.9
Headache pain in last month 1.5 2.6 7.4 -0.6 -0.6 2.2 -0.2 2.7
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 3.8 -1.5 -1.9 1.1 -0.8 -0.7
Glaucoma (self-reported) 0.9 1.1 2.2 -1.1 -1.5 0.9 -0.7 0.7
Gout (self-reported) 0.4 0.6 1.2 -0.2 -1.1 0.7 -1.1 -0.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.8 -0.7 -0.3 0.3 -0.9 0.5
Medication: Amlodipine 0.3 0.4 1.0 0.5 0.7 0.0 1.0 0.0
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.6 0.0 -0.1 0.1 -0.8 -0.2
Birth weight 0.5 1.2 3.6 -1.9 0.5 0.6 1.3 -0.1
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.4 -0.1 0.2 1.2 0.8 1.1
High blood pressure (siblings) 0.8 1.2 4.1 -0.1 -0.5 0.8 -2.0 -0.9
Forced vital capacity (FVC), Best measure 0.5 1.9 5.3 -0.7 -0.0 -2.0 -0.2 -2.3
Body fat percentage 0.8 3.1 5.2 -1.2 -1.5 2.3 1.8 1.9
Leg fat percentage (right) 1.4 5.1 12.1 -1.4 -2.4 3.5 1.3 2.0
Arm fat-free mass (right) 1.3 7.0 17.0 4.1 2.5 -1.4 0.9 -3.0
Exposure to tobacco smoke outside home 3.5 4.6 6.8 -2.0 -2.5 2.6 -0.9 2.4
Comparative body size at age 10 0.4 1.1 4.4 -0.8 0.5 0.6 0.2 2.1
Number of full brothers 0.8 1.0 1.8 1.1 1.4 0.8 0.8 -0.8
Worry too long after embarrassment 2.2 3.8 13.7 0.1 -0.7 3.7 0.1 2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.2 0.6 -0.1 -0.5 0.8 1.1
Wheeze or whistling in the chest in last year 1.1 1.9 6.3 0.8 -0.2 1.5 0.7 2.5
Number of children fathered 0.5 0.6 1.2 0.6 0.4 0.5 1.1 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 1.9 2.2 7.8 -2.8 -0.5 -0.6 -0.4 1.6
Age at first live birth 0.7 1.3 2.9 -0.6 0.6 -1.7 -1.2 -1.2
Pulse wave peak to peak time 0.7 0.8 2.0 -0.1 0.9 -0.6 -1.0 -1.4
Health satisfaction 1.7 2.2 5.1 1.4 1.7 1.0 -0.6 2.2
Shortness of breath walking on level ground 1.3 1.5 6.5 0.8 0.3 0.5 2.5 0.5
Qualifications: College or University degree 0.5 1.6 3.2 0.0 0.9 -1.8 -1.4 -1.3
Eye problems/disorders: None of the above 0.3 0.3 0.8 -0.3 0.1 0.9 0.8 0.3
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.5 0.3 -0.7 0.5 -0.4 -0.3
Emphysema/chronic bronchitis 0.8 0.9 3.9 -0.5 -0.2 2.0 0.4 -0.3
Medication for pain relief, constipation, heartburn 1.5 2.6 10.3 0.5 0.2 -1.0 3.2 -1.1
Neck or shoulder pain in last month 0.8 1.1 4.6 0.1 0.3 2.1 -0.4 -0.8
Medication: Blood pressure 0.3 0.6 0.8 0.8 0.9 -0.8 0.6 0.7
Angina (self-reported) 0.2 0.2 1.0 -0.2 1.0 0.3 -0.2 0.1
Migraine (self-reported) 0.5 0.6 1.3 -0.7 -0.0 1.0 0.3 1.1
Medication: Ibuprofen 2.0 2.4 5.4 -0.4 -1.2 0.7 -2.2 2.3
Medication: Allopurinol 1.3 1.7 4.6 1.2 0.3 -0.7 -2.1 -1.4
Medication: Omeprazole 0.5 0.5 2.2 -0.5 -0.4 1.5 -0.3 0.0
Medication: Seretide 50 evohaler 1.4 1.6 6.9 -0.1 0.4 0.7 2.6 0.8
Mean time to correctly identify matches 0.7 1.4 3.2 -1.0 0.0 -1.8 0.9 1.4
Heart disease (mother) 0.3 0.4 0.8 -0.9 -0.5 -0.7 0.3 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.0 -0.7 -1.0 0.3 0.3 -1.0
Whole body fat mass 0.3 1.3 3.0 0.2 -0.4 1.6 1.7 0.7
Leg fat mass (right) 0.4 1.6 4.8 0.5 -0.7 2.2 1.5 0.4
Arm predicted mass (right) 1.3 7.0 17.4 4.2 2.4 -1.4 1.1 -2.9
Pulse rate, automated reading 0.8 2.6 4.8 -0.0 -1.7 2.2 1.4 1.8
Alcohol intake frequency. 0.2 0.4 1.3 -0.5 -0.2 1.2 0.3 0.6
Comparative height size at age 10 0.8 4.4 15.3 1.6 0.6 -3.9 0.5 -1.9
Number of full sisters 0.5 0.6 1.0 1.0 -0.7 0.5 0.7 0.8
Suffer from ‘nerves’ 1.5 2.5 3.9 -1.8 -0.8 1.7 -1.2 2.0
Overall health rating 2.2 4.7 13.1 1.0 -0.1 3.6 -0.0 3.0
Chest pain or discomfort 0.2 0.3 0.9 0.4 0.9 0.7 -0.2 0.2
Had major operations 0.2 0.3 0.6 -0.3 0.8 0.4 -0.6 -0.3
Age at last live birth 0.7 1.0 1.9 0.6 1.1 -0.1 -1.2 -1.4
Family relationship satisfaction 0.5 0.6 2.3 0.4 -0.1 1.5 0.6 -0.0
Leg pain on walking 1.8 2.3 3.3 -1.4 -1.3 1.4 -1.8 1.5
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.7 0.3 0.2 0.1 -0.1 0.9
Commuting to job workplace: Car/motor vehicle 1.2 1.4 4.3 0.0 0.8 1.3 2.1 0.5
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 2.6 -1.6 -1.2 -0.7 1.2 -1.3
Medication: Aspirin 2.4 3.2 7.5 0.2 2.4 -1.2 -2.7 -1.0
Supplements: Vitamin C 0.2 0.2 0.7 -0.5 -0.3 0.3 -0.9 -0.0
Knee pain experienced in last month 1.9 3.0 7.3 0.0 -1.3 2.3 -0.9 2.7
Hypertension (Self-reported) 0.3 0.9 2.2 0.5 0.2 1.1 -0.9 1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 2.3 -0.1 1.2 -1.0 0.5 -1.5
Illnesses of father: Heart disease 3.1 4.2 9.7 3.1 3.0 -1.1 -0.4 -1.0
Illnesses of siblings: Diabetes 1.0 1.2 4.4 0.7 -0.3 0.5 0.9 -2.1
Smoking status: Previous 3.2 4.8 10.3 3.1 3.2 -1.0 0.2 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.7 0.3 -0.2 -0.7 0.3 -0.9
Whole body fat-free mass 1.1 6.6 15.7 4.0 2.5 -1.8 0.2 -2.8
Leg fat-free mass (right) 1.1 6.2 15.6 4.0 2.8 -1.1 0.8 -2.4
Arm fat percentage (left) 0.5 1.9 4.9 0.1 -0.3 2.2 1.7 1.2
Average weekly red wine intake 0.7 1.0 2.5 1.3 -0.4 -1.6 -0.8 -0.4
Handedness (chirality/laterality): Left-handed 2.6 3.1 7.7 -2.2 -1.1 0.6 -2.8 1.2
Mood swings 3.8 7.0 12.6 -2.6 -2.0 3.5 -1.3 3.2
Loneliness, isolation 0.4 0.6 2.1 -0.1 -0.1 1.4 -0.4 0.8
Long-standing illness, disability or infirmity 0.5 0.7 3.1 -0.4 -0.2 0.7 -0.1 1.8
Ever had bowel cancer screening 0.2 0.2 1.0 -0.2 0.2 0.1 -1.0 0.2
Diabetes diagnosed by doctor 0.6 1.1 2.0 1.3 1.4 -0.7 -0.8 0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 2.9 1.4 0.9 -0.1 -1.7 -1.4
Friendships satisfaction 0.3 0.3 0.7 0.2 0.9 0.6 0.5 0.4
Qualifications: nursing, teaching 0.8 1.3 3.5 0.9 1.3 -1.9 -0.7 -0.5
Commuting to job workplace: Walk 0.9 1.0 2.4 -0.2 -1.6 0.8 -0.1 1.4
Eye problems/disorders: Cataract 0.2 0.2 0.7 0.6 0.0 -0.8 -0.0 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 2.5 -0.5 -0.1 0.7 -1.6 0.2
Medication for cholesterol 0.3 0.5 1.8 -0.4 -0.1 -1.4 -0.1 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 3.8 0.5 -0.6 1.2 -2.0 0.8
Back pain experienced in last month 1.5 2.2 6.8 2.6 1.2 1.5 0.4 0.4
Mineral and other dietary supplements 1.7 2.3 5.0 1.5 2.2 -1.9 -0.2 -0.7
Breast cancer (self-reported) 0.1 0.1 0.1 -0.1 0.3 0.4 0.1 0.2
Asthma (self-reported) 0.3 0.6 1.3 0.4 0.8 -0.8 -0.5 1.1
Osteoporosis (self-reported) 0.2 0.2 0.5 -0.0 -0.5 0.1 0.7 0.6
Osteoarthritis (self-reported) 0.5 0.6 1.6 0.8 0.9 0.3 0.0 -1.2
Medication: Aspirin 2.2 2.9 7.6 0.5 2.2 -0.7 -2.8 -1.2
Medication: Gliclazide 0.3 0.4 0.8 0.5 0.6 -0.0 -0.9 0.7
Illnesses of father: None of the above (group 1) 0.6 0.7 2.2 -1.5 -1.0 -0.4 -0.0 0.3
Smoking status: Current 0.9 1.4 4.0 1.3 -1.0 2.0 0.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 3.6 -1.9 -0.1 -0.2 0.1 -0.4
Whole body water mass 1.1 6.5 15.5 3.9 2.5 -1.7 0.3 -2.8
Leg predicted mass (right) 1.1 6.2 16.1 4.0 2.7 -1.1 0.8 -2.4
Arm fat mass (left) 0.3 1.2 3.7 0.8 0.1 1.9 1.3 0.3
Number of self-reported non-cancer illnesses 0.4 0.6 1.6 0.6 0.8 1.3 -0.6 0.3
Average weekly champagne plus white wine intake 0.4 0.5 0.9 -0.8 -0.6 -0.0 -1.0 0.9
Miserableness 4.4 7.7 33.1 -0.7 -1.3 5.8 -1.3 1.2
Guilty feelings 3.8 5.7 19.5 -0.9 -2.2 4.4 -1.0 1.6
Wears glasses or contact lenses 0.1 0.2 0.3 0.5 -0.2 -0.4 0.3 -0.5
Ever taken oral contraceptive pill 0.6 0.7 2.0 1.4 1.1 -0.1 0.3 -0.2
Hearing aid user 1.1 1.3 2.9 0.6 -1.4 1.7 0.0 1.1
Mother’s age at death 0.6 0.7 1.2 1.0 0.5 -1.1 -0.8 -0.6
Financial situation satisfaction 0.9 1.1 3.3 -0.1 -0.6 1.8 -0.9 1.1
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.8 0.9 -0.6 1.3 -0.7 -0.6
Commuting to job workplace: Public transport 0.6 0.7 2.2 0.3 0.2 -1.5 -0.9 0.3
Eye problems/disorders: Glaucoma 0.4 0.4 0.7 -0.8 -0.8 0.7 -0.4 -0.5
Medication: Blood pressure 0.3 0.6 1.1 1.0 1.0 0.2 -1.0 0.0
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.0 -0.3 -0.4 1.0 -0.2 -0.3
Supplements: Fish oil (including cod liver oil) 1.6 2.1 4.7 -1.2 -1.8 2.2 -0.2 0.9
High cholesterol (Self-reported) 0.1 0.2 0.4 0.1 0.4 0.6 0.5 0.6
Medication: Bendroflumethiazide 0.2 0.4 1.2 -0.3 -0.6 0.1 -0.5 1.1
Medication: Paracetamol 0.2 0.3 0.9 0.1 -0.4 1.0 0.1 0.6
Medication: Lisinopril 0.7 0.9 2.1 1.4 1.0 0.9 -0.1 -0.6
Medication: Atorvastatin 0.8 1.0 4.0 -2.0 -0.4 0.2 0.5 0.9
Illnesses of father: High blood pressure 0.7 0.8 1.8 -0.1 0.4 0.9 -1.2 -1.3
Alcohol drinker status: Never 1.3 1.6 4.0 -1.6 -1.0 0.2 -0.1 2.0
Ever smoked 0.9 1.6 5.6 2.4 0.1 1.4 -0.7 -0.1
Basal metabolic rate 0.8 4.7 11.5 3.4 2.1 -1.1 0.6 -2.4
Leg fat percentage (left) 1.4 5.3 13.4 -1.5 -2.3 3.7 1.1 2.1
Arm fat-free mass (left) 0.7 3.8 8.9 3.0 1.7 -0.8 0.7 -2.5
Number of operations (self-reported) 0.6 1.0 1.7 1.1 0.5 0.3 -1.2 -1.3
Average weekly beer plus cider intake 0.1 0.2 0.7 0.0 0.8 -0.1 -0.2 -0.6
Irritability 4.6 7.8 16.8 -2.2 -2.7 4.1 -2.2 2.4
Risk taking 0.9 1.3 2.7 1.2 1.3 -1.6 -0.7 -0.2
Ever had prostate specific antigen (PSA) test 7.7 8.8 16.7 2.8 4.1 -4.0 1.7 -0.4
Fractured/broken bones in last 5 years 0.1 0.1 0.6 -0.1 -0.3 0.1 0.0 -0.8
Age started oral contraceptive pill 3.2 4.0 7.1 -2.4 -2.7 2.3 0.5 1.3
Diastolic blood pressure, automated reading 3.8 11.8 17.7 -4.1 -3.7 4.2 -0.3 3.3
Ever depressed for a whole week 1.4 1.7 4.8 1.4 2.2 0.6 -0.5 1.0
Unable to work because of sickness or disability 0.9 1.1 2.6 1.2 -0.5 0.9 1.6 0.6
Commuting to job workplace: Cycle 2.0 2.4 5.8 0.2 -0.7 -0.2 -2.4 -2.4
Myopia 1.2 1.7 3.3 -1.4 -1.8 1.4 0.6 1.0
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.3 -0.8 -0.5 -0.8 1.1 -1.1
Cholesterol lowering medication 0.8 1.1 4.4 -0.2 0.2 2.1 -0.7 0.8
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.3 -1.1 -1.0 1.5 0.1 0.3
Pain experienced in last month 1.3 2.2 6.8 -1.0 -0.5 -2.6 0.5 -1.6
Supplements: Calcium 0.5 0.6 1.7 -1.3 -0.7 0.4 -0.7 -0.0
Basal cell carcinoma (self-reported) 0.5 0.6 2.4 0.2 0.4 -1.6 -0.2 -0.6
Heart attack/myocardial infarction (self-reported) 1.8 2.3 4.5 2.1 2.1 -1.4 0.4 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.1 1.0 1.1 -0.8 -0.7 -0.1
Heart disease (siblings) 0.6 0.8 2.3 1.5 -0.2 0.2 -0.7 -1.0
Alcohol drinker status: Previous 0.1 0.1 0.2 -0.4 -0.5 0.3 -0.2 0.0
Pack years of smoking 2.0 3.0 5.3 -1.1 -2.3 2.0 1.7 1.1
Impedance of whole body 1.9 9.7 25.0 -5.0 -3.2 -0.2 1.1 3.5
Leg fat mass (left) 0.4 1.6 5.3 0.5 -0.7 2.3 1.4 0.4
Arm predicted mass (left) 0.7 3.8 9.1 3.0 1.6 -0.9 0.6 -2.5