Hub : Genes

PPARG

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.57 0.079 7.1e-09 0.570 NA 0.439 NA 0.535 1.2e-17 NA 1.2e-12 NA 3.6e-16
2 GTEx Brain Cerebellum 0.64 0.067 2.5e-12 0.568 NA 0.504 NA 0.567 3.7e-20 NA 3.9e-17 NA 4.1e-20
3 GTEx Cells EBV-transformed lymphocytes 0.23 0.081 6.9e-04 0.093 NA 0.033 NA 0.074 5.8e-04 NA 3.0e-02 NA 2.1e-03
4 GTEx Heart Left Ventricle 0.25 0.063 3.7e-06 0.066 NA 0.101 NA 0.048 2.1e-04 NA 5.1e-06 NA 1.4e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Alzheimer’s Disease (in mother) 0.8 1.0 2.3 -0.8 -0.8 -1.5 -0.5
Alzheimer’s Disease (in father) 0.4 0.4 0.6 0.5 0.7 -0.5 -0.8
Alzheimer’s Disease (including proxy) 1.1 1.5 4.3 -0.3 -0.2 -2.1 -1.2
Crohns Disease (2017) 0.6 1.4 3.0 1.1 1.1 1.7 -0.6
Irritable Bowel Disease (IBD) 0.9 2.1 3.2 1.2 1.4 1.3 -1.8
Ulcerative Colitis (UC) 1.0 1.9 4.0 1.1 1.4 0.6 -2.0
Major Depression (MDD) 0.6 0.7 1.6 -0.2 -0.5 1.1 1.3
Reaction Time 0.6 1.1 1.8 -0.5 -0.8 1.3 1.3
Verbal and Numeric Reasoning (VNR) 2.0 4.9 8.8 2.3 3.0 0.8 -2.2
Breast Cancer 1.6 4.0 7.5 -1.9 -2.0 1.1 2.7
Ovarian Cancer 0.5 0.7 1.3 1.1 0.8 0.8 -0.4
Prostate Cancer 1.5 2.2 3.3 1.6 1.7 1.8 -0.1
Age at First Birth 1.0 1.4 2.2 1.3 1.5 -0.6 -1.3
Bipolar Disorder 0.2 0.2 0.5 -0.4 -0.7 0.3 -0.2
Body Mass Index (BMI) (2010) 2.4 3.3 6.5 -1.2 -1.7 1.5 2.6
Coronary Artery Disease (CAD) 0.6 0.7 1.5 1.2 1.1 0.2 0.3
Crohns Disease (2012) 0.7 1.2 2.2 -0.8 -0.9 -1.5 -1.1
Mean Putamen Volume 2.0 2.3 4.6 0.5 0.6 2.1 2.0
Fasting Glucose 0.7 0.8 1.7 0.8 0.7 -0.8 -1.3
HbA1C 0.2 0.2 0.6 0.0 -0.0 -0.4 -0.8
HDL Cholesterol 1.8 3.0 4.8 1.3 1.6 2.2 1.6
LDL Cholesterol 0.3 0.4 1.4 0.1 0.1 -0.3 1.2
Lupus 1.8 2.7 6.1 -1.3 -1.3 -2.5 -1.2
Neuroticism 1.0 1.4 5.4 0.0 0.1 2.3 0.5
Primary Biliary Cirrhosis 0.5 0.8 1.3 -0.9 -1.1 0.0 1.0
Rheumatoid Arthritis 2.7 3.7 12.5 -0.6 -0.9 -3.5 -0.9
Schizophrenia 0.7 1.6 2.1 -1.2 -1.3 1.5 1.0
Triglycerides 1.4 2.3 5.8 -0.7 -0.6 -2.4 -1.5
Type 2 Diabetes (T2D) 5.6 6.6 11.9 1.7 1.7 -2.9 -3.4
Ulcerative Colitis 0.1 0.1 0.3 0.6 0.3 0.3 -0.1
Blood Eosinophil Count 8.8 69.7 95.7 9.8 9.7 9.4 -0.6
Blood Platelet Count 2.9 33.5 83.7 3.0 3.0 9.2 5.7
Blood Red Count 6.9 67.9 125.4 -7.5 -7.9 -11.2 -5.2
Blood White Count 0.2 1.3 2.7 -0.7 -0.6 -1.6 -1.4
Heel T-Score 0.8 6.6 19.9 0.4 0.0 -2.5 -4.5
BMI 3.0 17.7 27.6 -4.2 -4.6 2.0 5.2
Height 0.3 5.9 13.8 -1.1 -0.5 3.7 2.9
Waist Hip Ratio (WHR) 3.2 14.5 38.4 1.8 1.4 6.2 3.8
Systolic Blood Pressure 0.6 3.2 6.0 0.7 0.7 -2.4 -2.4
Smoking Status 0.3 0.8 1.5 0.5 0.7 -1.2 -0.9
Allergy or Eczema 3.7 9.6 15.2 3.9 3.8 2.9 -0.6
Cardiovascular Disease 0.0 0.1 0.1 -0.3 -0.3 0.0 0.3
Hypothyroidism (self reported) 0.3 0.6 0.9 -0.8 -0.9 -0.5 -1.0
Respiratory disease 3.9 8.5 13.9 3.5 3.7 2.5 -1.3
Type 2 Diabetes (T2D) 4.4 8.2 22.7 0.9 1.0 -4.8 -2.9
Lung FEV1/FVC ratio 1.5 7.6 14.5 -2.7 -3.0 0.2 3.8
Lung FVC 0.3 1.3 3.8 0.6 1.0 -2.0 -0.0
Neuroticism 1.0 2.5 7.0 1.0 1.2 2.6 0.9
Chronotype (morning person) 1.8 4.1 5.6 1.9 1.6 -2.4 -2.1
Hair Pigment 0.0 1.5 3.3 -1.1 -1.8 -1.1 -0.6
Tanning 0.1 1.7 2.9 1.5 1.7 1.0 -0.7
Hand grip strength (left) 0.6 1.6 5.4 -0.3 -0.7 -0.6 2.3
Number of treatments/medications taken 0.2 0.3 0.6 0.3 0.4 0.8 -0.6
Average weekly spirits intake 0.4 0.5 0.8 0.8 0.9 0.4 -0.7
Sensitivity / hurt feelings 0.3 0.6 1.1 -0.8 -0.8 -0.1 -1.0
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.7 -0.3 -0.1 -1.3 -1.0
Hearing difficulty/problems: Yes 4.1 6.3 9.1 -3.0 -2.9 -2.7 0.3
Relative age of first facial hair 1.1 2.4 4.2 -1.9 -2.0 -1.2 -0.1
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.6 0.5 0.6 1.2 -0.7
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.7 0.8 0.6 0.8 -0.5
Ever had hysterectomy (womb removed) 0.5 0.6 1.3 -0.8 -0.7 -0.0 -1.2
Systolic blood pressure, automated reading 0.4 1.1 2.4 0.9 0.9 1.5 0.8
Eye problems/disorders: Diabetes related eye disease 2.8 3.1 6.3 1.0 0.8 2.5 2.1
Angina 0.3 0.4 1.4 0.1 0.0 -0.5 -1.2
Medication for hormone replacement therapy 0.6 0.7 2.2 -0.0 -0.1 1.5 0.8
Vitamin and mineral supplements 0.1 0.2 0.5 -0.3 -0.3 0.0 0.7
Supplements: Zinc 2.8 3.1 5.5 -2.3 -2.3 -0.3 1.2
Medication: Co-codamol 1.1 1.3 4.0 -0.7 -0.7 0.3 2.0
Medication: Metformin 3.0 4.2 8.5 -0.8 -0.8 2.9 2.6
Diabetes (father) 2.2 2.8 6.1 0.2 0.4 2.5 2.2
Diabetes (mother) 4.8 6.2 14.9 0.1 0.1 3.9 3.1
Severe depression (siblings) 0.2 0.2 0.5 0.1 0.3 -0.6 -0.7
Pack years adult smoking proportion 0.6 0.9 2.1 0.6 0.4 -1.4 -1.1
Impedance of leg (right) 3.2 15.9 34.6 0.8 0.8 -5.9 -5.3
Leg fat-free mass (left) 0.6 3.0 5.5 2.3 2.4 0.2 -1.2
Trunk fat percentage 11.1 45.7 75.9 6.1 6.6 -5.1 -8.7
Hand grip strength (right) 0.4 1.0 1.7 -0.4 -0.9 -1.3 1.2
Townsend deprivation index at recruitment 0.4 0.5 0.6 0.8 0.7 0.7 0.7
Current tobacco smoking 0.9 1.5 4.3 0.4 0.5 2.1 1.2
Average weekly fortified wine intake 0.2 0.2 0.5 -0.5 -0.5 -0.2 -0.7
Maternal smoking around birth 1.8 2.6 4.0 -1.1 -1.0 2.0 2.0
Fed-up feelings 0.5 0.9 2.5 -0.7 -0.5 -1.6 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 3.4 0.7 0.9 -0.7 -1.8
Relative age voice broke 3.4 5.3 9.9 -3.2 -3.1 -1.2 -0.6
Taking other prescription medications 0.3 0.4 1.7 -0.1 -0.1 -0.2 -1.3
Age when periods started (menarche) 0.1 0.3 0.6 -0.1 -0.1 0.7 -0.8
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.3 0.5 0.4 1.1 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 4.5 -0.1 -0.1 1.5 2.1
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 1.9 1.2 1.4 0.8 -1.0
Qualifications: CSEs or equivalent 0.1 0.2 0.4 0.5 0.6 -0.0 0.0
Serious illness, injury or assault to yourself 0.8 1.0 2.6 -0.6 -0.8 0.6 1.6
High blood pressure 0.2 0.5 1.1 0.2 0.2 1.1 0.9
Hayfever, allergic rhinitis or eczema 4.7 10.1 14.7 -3.8 -3.8 -3.3 0.8
Multivitamins +/- minerals 0.2 0.2 0.4 -0.4 -0.3 -0.3 -0.7
Stomach or abdominal pain in last month 0.7 0.8 2.3 -0.4 -0.4 1.5 0.8
Supplements: Glucosamine 0.4 0.5 1.0 -0.3 -0.2 1.0 1.0
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.4 -0.5 -0.5 0.3 -1.2
Medication: Atenolol 1.6 2.0 2.7 -1.6 -1.6 -1.6 -0.4
Medication: Levothyroxine sodium 0.2 0.3 0.6 0.6 0.8 -0.5 -0.3
Sitting height 0.1 0.8 1.5 0.7 0.3 -1.2 -1.0
Chronic bronchitis/emphysema (father) 0.3 0.3 0.6 -0.2 -0.3 0.8 0.7
High blood pressure (mother) 1.6 2.3 4.0 1.2 1.2 -1.5 -2.0
Body mass index (BMI) 2.2 9.8 13.7 3.3 3.7 -1.1 -3.7
Impedance of leg (left) 2.9 14.5 27.7 1.3 1.4 -5.2 -5.3
Leg predicted mass (left) 0.5 2.9 5.3 2.2 2.3 0.2 -1.2
Trunk fat mass 7.9 34.8 56.0 5.5 5.9 -4.3 -7.5
Waist circumference 3.5 13.0 23.3 2.7 3.1 -3.5 -4.8
Number of incorrect matches in round 1.2 2.0 4.1 1.4 1.3 2.0 -0.5
Past tobacco smoking 0.3 0.6 1.0 0.8 1.0 -0.3 -0.9
Alcohol usually taken with meals 0.7 1.1 2.1 0.6 0.7 -1.3 -1.5
Nervous feelings 1.0 2.0 3.5 -1.8 -1.9 -1.0 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.8 0.4 0.7 -0.0 -1.7
Hearing difficulty/problems with background noise 2.0 3.3 5.9 -2.4 -2.4 -0.9 0.9
Hair/balding pattern: Pattern 2 0.6 0.8 1.1 1.0 1.0 0.9 0.6
Had menopause 1.8 2.2 3.4 1.8 1.6 1.7 0.3
Had other major operations 2.8 3.5 4.2 -2.1 -2.0 1.7 1.7
Forced vital capacity (FVC) 0.1 0.2 0.4 -0.2 -0.7 -0.0 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 5.2 0.4 0.5 1.4 2.3
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.4 -0.2 0.3 -1.2 -0.8
Qualifications: None of the above 1.2 2.7 4.3 1.6 2.1 1.4 -1.4
Financial difficulties in last 2 years 0.3 0.4 0.5 -0.7 -0.6 -0.7 -0.6
Mouth/teeth dental problems 1.4 2.1 4.0 2.0 1.9 0.7 -0.7
Heart attack 0.7 0.9 2.4 0.2 0.3 -1.5 -1.0
Allergy 5.7 12.9 18.6 4.3 4.3 3.5 -1.5
Pain all over the body in last month 0.7 0.7 1.5 1.0 1.2 0.5 -0.3
Diabetes (self-reported) 2.3 3.6 12.8 0.1 -0.1 3.6 1.2
Hayfever/allergic rhinitis (self-reported) 2.2 2.9 4.4 -1.8 -1.9 -2.1 -0.7
Medication: Ramipril 0.0 0.0 0.1 -0.2 -0.1 0.1 0.3
Medication: Simvastatin 2.1 3.0 4.4 2.1 1.9 1.0 -1.7
Fluid intelligence score 1.6 3.3 5.1 -1.5 -2.3 -2.3 0.7
Illnesses of siblings 0.8 1.2 4.1 -0.3 -0.5 -2.0 -0.4
Neuroticism score 1.4 3.0 5.9 -1.7 -1.7 -2.4 -0.7
Weight 2.9 14.7 23.6 3.7 3.9 -2.5 -4.9
Impedance of arm (right) 4.4 20.8 41.7 1.8 1.9 -5.9 -6.5
Arm fat percentage (right) 6.9 27.7 45.8 4.7 5.2 -4.1 -6.8
Trunk fat-free mass 0.1 0.7 0.9 0.7 0.5 1.0 1.0
Hip circumference 1.7 7.6 10.0 3.0 3.1 -1.3 -3.2
Time employed in main current job 0.3 0.3 0.5 0.7 0.7 0.0 -0.4
Alcohol intake versus 10 years previously 3.1 4.6 12.5 1.5 1.7 3.5 0.8
Father’s age at death 0.2 0.3 0.6 -0.6 -0.8 0.1 0.6
Worrier / anxious feelings 0.1 0.2 0.4 0.1 0.1 0.6 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 2.4 0.4 0.6 -0.6 -1.6
Falls in the last year 0.3 0.4 0.8 0.0 0.2 -0.9 -0.9
Hair/balding pattern: Pattern 3 1.4 2.1 3.2 1.7 1.8 -0.1 -1.4
Number of live births 0.7 1.0 2.7 0.3 0.2 -1.1 -1.6
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 4.4 0.8 0.6 -0.7 -2.1
Pulse rate 0.2 0.4 0.7 -0.1 -0.3 0.9 0.9
Happiness 0.7 0.8 2.7 -0.3 -0.2 -1.7 -0.7
Noisy workplace 0.5 0.6 1.4 0.7 0.6 1.2 0.4
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.9 0.9 0.4 0.0 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 0.6 0.7 0.7 0.8 0.4
Mouth/teeth dental problems: Dentures 0.2 0.3 0.8 -0.1 -0.3 -0.9 -0.7
Asthma 4.2 8.1 13.9 -3.5 -3.7 -2.0 1.6
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.9 2.6 -1.6 -1.3 -1.5 -1.0
Medication: Cholesterol lowering 1.4 2.1 4.5 1.2 1.3 -0.8 -2.1
Depression (self-reported) 2.5 3.0 6.4 -1.2 -0.8 -2.5 -1.9
Medication: Lansoprazole 0.3 0.3 0.6 0.5 0.4 -0.6 -0.8
Prospective memory result 1.5 1.8 2.8 1.5 1.7 1.5 0.1
Lung cancer (father) 3.2 3.7 6.3 2.5 2.3 1.2 -1.3
Illnesses of mother 1.1 1.4 2.3 -1.5 -1.5 0.1 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 6.6 0.4 0.1 -1.1 -2.6
Pulse wave Arterial Stiffness index 4.1 4.8 12.0 1.3 1.1 3.5 2.1
Impedance of arm (left) 3.6 16.9 34.5 1.9 2.0 -5.0 -5.9
Arm fat mass (right) 4.8 20.3 31.6 4.3 4.6 -3.1 -5.6
Trunk predicted mass 0.1 0.5 0.9 0.6 0.4 0.9 0.9
Standing height 0.4 4.3 8.4 1.2 0.8 -2.9 -2.6
Length of working week for main job 0.8 0.8 2.0 0.6 0.8 -0.7 1.4
Exposure to tobacco smoke at home 0.6 0.7 2.2 -0.4 -0.3 0.5 1.5
Breastfed as a baby 1.3 1.7 2.6 -1.1 -1.4 0.8 1.6
Tense / ‘highly strung’ 0.0 0.1 0.1 -0.3 -0.2 0.2 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 4.0 -2.0 -1.7 -1.0 0.0
Hair/balding pattern: Pattern 4 0.9 2.2 4.2 -1.8 -2.0 -0.5 1.0
Birth weight of first child 3.3 5.9 12.5 2.0 2.0 3.5 1.8
Peak expiratory flow (PEF) 0.9 2.2 5.0 0.4 0.0 -1.9 -2.2
Pulse wave reflection index 1.8 2.2 5.1 1.2 1.2 2.2 0.9
Ever highly irritable/argumentative for 2 days 1.2 1.4 2.6 -1.2 -1.2 -1.6 -0.3
Loud music exposure frequency 1.1 1.2 2.4 -1.1 -1.0 0.1 -1.5
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 0.9 -0.6 -0.9 -0.1 0.7
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.5 -1.2 -1.1 -0.8 0.4
Blood clot in the leg (DVT) 0.8 1.0 1.8 -1.3 -1.3 -0.3 0.7
Medication: Paracetamol 0.2 0.4 1.0 0.2 0.7 -0.2 -1.0
Headache pain in last month 0.6 1.0 1.9 0.1 0.5 -1.3 -1.4
Medication for cholesterol, blood pressure or diabetes 1.8 3.0 5.1 -2.1 -2.3 -1.0 1.3
Glaucoma (self-reported) 0.9 1.1 2.7 -0.4 -0.6 -1.6 -1.1
Gout (self-reported) 1.9 2.6 7.9 1.0 1.0 2.8 0.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 1.1 0.9 1.0 0.1 -0.2
Medication: Amlodipine 1.3 1.9 4.2 1.2 1.3 2.1 0.1
Medication: Ventolin 100micrograms inhaler 2.1 2.7 3.9 -1.7 -2.0 -1.6 1.2
Birth weight 0.4 0.9 1.3 1.1 1.0 0.8 -0.7
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.7 0.5 0.2 -1.3 -1.1
High blood pressure (siblings) 0.6 0.9 2.9 0.5 0.8 1.7 -0.2
Forced vital capacity (FVC), Best measure 0.4 1.3 1.8 -0.8 -1.2 -1.3 -1.2
Body fat percentage 10.1 41.0 68.9 5.7 6.2 -5.0 -8.3
Leg fat percentage (right) 8.2 30.2 54.5 4.4 4.9 -4.8 -7.4
Arm fat-free mass (right) 0.3 1.6 2.7 1.6 1.6 1.1 0.1
Exposure to tobacco smoke outside home 0.7 0.9 1.1 -0.9 -0.8 1.0 1.0
Comparative body size at age 10 0.2 0.5 0.8 0.8 0.9 0.7 0.2
Number of full brothers 0.7 0.9 1.8 1.1 1.4 0.6 -0.6
Worry too long after embarrassment 1.4 2.4 5.5 -1.4 -1.5 -2.3 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.6 5.5 -0.2 -0.3 -2.3 -2.1
Wheeze or whistling in the chest in last year 3.0 5.4 10.8 -2.9 -3.3 -1.4 0.7
Number of children fathered 0.9 1.0 1.6 0.9 1.2 0.0 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.6 1.3 1.2 0.6 -0.2
Age at first live birth 0.5 0.8 1.0 -0.8 -1.0 0.7 1.0
Pulse wave peak to peak time 4.3 5.0 13.2 -1.2 -1.0 -3.6 -2.2
Health satisfaction 1.5 2.0 3.6 -1.9 -1.8 -0.6 0.9
Shortness of breath walking on level ground 0.6 0.7 2.2 -0.3 -0.2 -0.6 -1.5
Qualifications: College or University degree 1.0 3.2 5.0 -1.9 -2.2 -2.0 -0.2
Eye problems/disorders: None of the above 0.2 0.2 0.5 0.0 -0.1 0.6 0.7
Mouth/teeth dental problems: Loose teeth 1.3 1.5 2.5 -1.4 -1.2 0.5 1.6
Emphysema/chronic bronchitis 1.0 1.2 1.8 -1.3 -1.4 -0.3 1.0
Medication for pain relief, constipation, heartburn 0.8 1.4 4.9 -0.0 -0.5 0.6 2.2
Neck or shoulder pain in last month 1.1 1.6 2.7 -1.4 -1.3 -0.3 1.7
Medication: Blood pressure 0.3 0.5 0.9 0.7 0.9 1.0 -0.1
Angina (self-reported) 0.7 0.9 2.1 -0.4 -0.4 -1.0 -1.4
Migraine (self-reported) 1.3 1.6 3.0 1.6 1.7 0.4 -1.0
Medication: Ibuprofen 0.7 0.9 2.0 -0.8 -0.3 -1.0 -1.4
Medication: Allopurinol 1.3 1.8 5.8 0.3 0.2 2.4 1.1
Medication: Omeprazole 0.5 0.5 1.9 -0.1 0.0 -0.4 -1.4
Medication: Seretide 50 evohaler 5.6 6.4 11.8 -3.2 -3.4 -1.3 1.5
Mean time to correctly identify matches 0.6 1.1 2.2 0.3 0.6 -1.5 -1.3
Heart disease (mother) 0.2 0.2 0.5 -0.1 -0.1 -0.7 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 0.9 0.6 0.7 0.0 -1.0
Whole body fat mass 6.7 28.8 45.3 5.1 5.5 -3.8 -6.7
Leg fat mass (right) 5.7 22.9 37.6 4.2 4.7 -3.8 -6.1
Arm predicted mass (right) 0.3 1.5 2.4 1.5 1.6 1.1 0.1
Pulse rate, automated reading 1.0 3.1 4.2 2.0 1.7 2.0 -1.2
Alcohol intake frequency. 1.2 2.9 6.0 1.9 2.4 1.0 -1.1
Comparative height size at age 10 1.1 6.3 16.2 1.6 1.3 -2.1 -4.0
Number of full sisters 0.2 0.2 0.4 -0.6 -0.5 0.3 -0.5
Suffer from ‘nerves’ 2.4 3.8 7.4 -2.1 -1.9 -2.7 -0.4
Overall health rating 0.1 0.1 0.4 -0.3 0.0 -0.7 0.1
Chest pain or discomfort 0.3 0.5 0.9 -0.4 -0.7 -0.7 1.0
Had major operations 0.4 0.5 0.8 0.6 0.5 0.8 -0.9
Age at last live birth 0.0 0.1 0.1 -0.3 -0.4 0.2 -0.1
Family relationship satisfaction 3.0 3.7 4.9 -2.1 -2.1 1.1 2.2
Leg pain on walking 0.2 0.3 0.7 -0.0 0.3 0.5 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 1.5 -1.2 -1.2 -0.5 0.7
Commuting to job workplace: Car/motor vehicle 1.6 1.9 4.5 0.8 0.9 -1.2 -2.1
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.5 0.6 0.7 -0.0 -0.1
Medication: Aspirin 1.1 1.4 3.8 0.8 1.1 0.4 -1.9
Supplements: Vitamin C 0.1 0.1 0.2 -0.2 -0.3 0.4 -0.2
Knee pain experienced in last month 1.2 1.9 3.4 1.7 1.9 0.6 -1.1
Hypertension (Self-reported) 0.1 0.2 0.5 -0.1 0.0 0.6 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.6 0.0 -0.2 -0.8 0.4
Illnesses of father: Heart disease 0.2 0.3 0.5 -0.2 -0.5 0.7 0.7
Illnesses of siblings: Diabetes 3.3 4.1 10.8 1.0 1.0 3.3 1.8
Smoking status: Previous 0.6 1.0 1.5 -1.1 -1.2 -0.8 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.9 -0.7 -1.0 -0.4 0.3
Whole body fat-free mass 0.2 1.2 2.2 1.5 1.4 0.8 0.2
Leg fat-free mass (right) 0.5 2.5 4.5 2.1 2.1 1.0 -0.5
Arm fat percentage (left) 6.5 26.5 42.5 4.8 5.2 -3.6 -6.5
Average weekly red wine intake 1.5 2.3 3.2 -1.5 -1.6 -1.8 1.1
Handedness (chirality/laterality): Left-handed 1.7 2.1 3.0 -1.6 -1.3 -1.7 -1.1
Mood swings 1.2 2.2 6.2 -0.7 -0.5 -2.5 -1.3
Loneliness, isolation 1.0 1.3 4.9 0.0 -0.1 -2.2 -0.6
Long-standing illness, disability or infirmity 0.7 1.1 4.5 -0.0 -0.1 2.1 -0.1
Ever had bowel cancer screening 1.8 2.2 4.2 1.8 2.0 1.1 0.2
Diabetes diagnosed by doctor 2.2 3.6 11.4 -0.5 -0.6 3.4 1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.0 0.1 0.0 -0.1 -0.2
Friendships satisfaction 0.5 0.6 0.8 -0.9 -0.8 -0.8 0.2
Qualifications: nursing, teaching 3.2 5.0 8.9 -2.7 -3.0 -1.8 0.7
Commuting to job workplace: Walk 1.4 1.5 3.1 -1.6 -1.8 -0.4 0.2
Eye problems/disorders: Cataract 0.1 0.1 0.3 0.3 0.3 -0.5 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.9 -1.4 -1.1 0.7 0.5
Medication for cholesterol 0.3 0.4 1.5 0.2 0.4 -1.2 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.4 0.2 0.3 0.6 -0.5
Back pain experienced in last month 0.3 0.5 1.8 0.2 0.4 -1.4 -0.1
Mineral and other dietary supplements 0.3 0.4 0.6 -0.6 -0.8 -0.7 -0.4
Breast cancer (self-reported) 2.1 2.6 4.0 -1.8 -2.0 -0.6 1.6
Asthma (self-reported) 4.4 8.6 14.5 -3.5 -3.8 -2.3 1.5
Osteoporosis (self-reported) 0.7 0.8 1.4 1.0 1.2 -0.9 -0.0
Osteoarthritis (self-reported) 1.5 1.9 4.2 1.2 1.3 2.0 -0.5
Medication: Aspirin 0.4 0.5 1.9 -0.0 0.1 0.0 -1.4
Medication: Gliclazide 2.9 3.3 6.6 -1.3 -1.1 2.6 1.9
Illnesses of father: None of the above (group 1) 0.6 0.8 1.5 0.8 0.9 -0.2 -1.2
Smoking status: Current 0.9 1.5 4.9 0.3 0.4 2.2 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 1.1 -0.1 -0.3 0.2 -1.0
Whole body water mass 0.3 1.5 2.5 1.6 1.6 0.9 0.2
Leg predicted mass (right) 0.5 2.6 4.8 2.1 2.2 0.9 -0.5
Arm fat mass (left) 5.0 21.0 33.2 4.4 4.8 -3.0 -5.8
Number of self-reported non-cancer illnesses 0.0 0.1 0.1 -0.2 -0.3 -0.2 0.3
Average weekly champagne plus white wine intake 1.6 2.3 3.4 1.6 1.9 -0.5 -1.6
Miserableness 0.5 0.9 3.0 0.4 0.5 -1.7 -0.3
Guilty feelings 0.9 1.4 1.9 -1.4 -1.4 -1.4 0.2
Wears glasses or contact lenses 0.2 0.2 0.7 -0.3 -0.3 0.9 -0.2
Ever taken oral contraceptive pill 0.3 0.4 1.4 0.1 -0.0 0.3 1.2
Hearing aid user 0.5 0.6 1.2 0.1 0.2 -1.0 -1.1
Mother’s age at death 0.6 0.8 1.7 0.9 0.7 1.3 0.0
Financial situation satisfaction 0.1 0.2 0.6 -0.4 -0.0 -0.1 -0.8
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.7 -0.7 -0.7 -0.4 0.8
Commuting to job workplace: Public transport 1.5 1.8 3.2 -1.0 -0.9 1.8 1.5
Eye problems/disorders: Glaucoma 0.6 0.7 1.4 -0.4 -0.4 -1.2 -1.0
Medication: Blood pressure 0.6 1.1 1.7 -0.8 -0.9 1.1 1.3
Pain type(s) experienced in last month: Hip pain 2.0 2.5 4.2 1.9 2.0 1.5 0.3
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.8 0.8 0.9 0.3 -0.4
High cholesterol (Self-reported) 0.4 0.7 1.8 -0.2 -0.6 -0.7 -1.3
Medication: Bendroflumethiazide 0.4 0.6 1.3 -0.8 -0.8 -1.1 -0.1
Medication: Paracetamol 0.5 0.8 2.3 0.4 0.9 -0.3 -1.5
Medication: Lisinopril 2.9 3.7 7.1 2.6 2.7 1.1 -0.2
Medication: Atorvastatin 0.1 0.1 0.2 -0.4 -0.5 0.2 -0.3
Illnesses of father: High blood pressure 0.9 1.1 1.7 -1.2 -1.3 -0.3 1.1
Alcohol drinker status: Never 2.1 2.6 7.1 1.1 1.3 -0.4 -2.7
Ever smoked 0.6 1.0 2.1 -0.7 -1.0 0.6 1.4
Basal metabolic rate 0.5 2.8 4.9 2.2 2.2 -0.1 -1.3
Leg fat percentage (left) 8.2 30.3 52.0 4.8 5.3 -4.3 -7.2
Arm fat-free mass (left) 0.3 1.5 2.8 1.7 1.7 0.6 -0.4
Number of operations (self-reported) 1.1 1.7 5.4 -0.2 -0.1 2.3 1.2
Average weekly beer plus cider intake 1.0 1.5 3.0 -1.6 -1.7 0.5 0.4
Irritability 1.8 3.1 4.3 -2.1 -2.0 -1.7 1.0
Risk taking 0.2 0.2 0.3 -0.5 -0.5 0.4 0.5
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 0.1 0.1 0.2 0.4
Fractured/broken bones in last 5 years 0.2 0.2 0.6 0.4 0.3 -0.3 -0.8
Age started oral contraceptive pill 0.3 0.3 0.6 0.8 0.6 0.4 -0.4
Diastolic blood pressure, automated reading 2.0 6.2 9.7 2.7 3.1 -0.7 -2.7
Ever depressed for a whole week 2.1 2.6 4.3 -1.7 -1.3 -2.1 1.3
Unable to work because of sickness or disability 0.4 0.5 1.0 0.8 1.0 -0.6 -0.1
Commuting to job workplace: Cycle 2.9 3.5 4.8 -2.1 -2.2 -0.3 2.2
Myopia 0.6 0.8 1.4 0.8 0.8 1.2 0.8
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.3 -0.4 -0.4 -0.5 -0.4
Cholesterol lowering medication 1.3 1.9 5.6 1.1 0.7 2.4 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.4 0.2 0.2 -0.6 -1.2
Pain experienced in last month 0.6 1.0 2.1 -1.2 -1.5 0.3 0.6
Supplements: Calcium 1.1 1.2 2.4 -0.7 -0.9 1.0 1.6
Basal cell carcinoma (self-reported) 2.6 3.1 6.0 2.4 2.4 0.4 -0.8
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.6 0.2 0.3 -1.2 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.1 -1.0 -1.1 0.0 0.6
Heart disease (siblings) 0.0 0.0 0.1 -0.1 0.1 0.1 -0.4
Alcohol drinker status: Previous 1.1 1.3 2.5 1.4 1.6 -0.5 -0.6
Pack years of smoking 0.7 1.0 2.6 0.5 0.3 -1.6 -1.1
Impedance of whole body 3.4 17.5 34.5 1.6 1.6 -5.5 -5.9
Leg fat mass (left) 5.9 23.6 37.6 4.5 4.9 -3.6 -6.1
Arm predicted mass (left) 0.4 2.3 4.4 2.1 2.1 0.6 -0.4