Hub : Genes

PPP1R13B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.04 0.019 2.2e-03 0.025 0.019 0.021 0.019 0.019 4.5e-04 0.0018 1.3e-03 0.0021 1.7e-03
2 GTEx Adipose Subcutaneous 0.04 0.022 5.6e-03 0.017 NA 0.007 NA 0.011 1.3e-02 NA 7.8e-02 NA 4.1e-02
3 GTEx Cells EBV-transformed lymphocytes 0.15 0.063 1.9e-03 0.080 NA 0.070 NA 0.073 1.4e-03 NA 2.7e-03 NA 2.2e-03
4 GTEx Esophagus Gastroesophageal Junction 0.08 0.042 7.9e-03 0.082 NA 0.033 NA 0.048 6.8e-04 NA 2.3e-02 NA 7.9e-03
5 GTEx Esophagus Mucosa 0.21 0.064 5.2e-04 0.007 NA 0.078 NA 0.081 1.0e-01 NA 7.0e-06 NA 4.2e-06
6 GTEx Esophagus Muscularis 0.12 0.036 1.6e-06 0.072 NA 0.067 NA 0.072 3.8e-05 NA 6.8e-05 NA 3.9e-05
7 GTEx Thyroid 0.08 0.033 4.4e-04 0.055 NA 0.043 NA 0.039 4.8e-05 NA 2.8e-04 NA 5.9e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Alzheimer’s Disease (in mother) 3.1 3.5 6.0 -1.8 -2.0 -2.0 -1.8 -0.7 -2.0 2.5
Alzheimer’s Disease (in father) 1.5 1.6 3.2 0.2 -0.9 -0.5 -1.7 -1.8 -1.0 1.8
Alzheimer’s Disease (including proxy) 2.7 3.8 7.9 -1.2 -2.0 -1.8 -2.2 -1.3 -1.9 2.8
Crohns Disease (2017) 0.7 1.4 2.3 0.8 1.3 1.4 1.5 0.6 1.2 -1.3
Irritable Bowel Disease (IBD) 0.1 0.2 0.9 0.2 -0.2 0.3 0.3 1.0 -0.2 0.5
Ulcerative Colitis (UC) 0.5 1.0 2.9 -0.5 -1.2 -0.7 -0.5 0.8 -1.1 1.7
Major Depression (MDD) 2.5 3.1 5.6 0.0 -1.7 -2.3 -2.4 -0.4 -2.1 1.8
Reaction Time 0.1 0.2 0.6 -0.8 0.4 -0.0 0.3 -0.6 0.3 -0.5
Verbal and Numeric Reasoning (VNR) 2.8 6.7 11.9 -3.4 -2.7 -2.4 -2.2 -1.0 -2.7 2.9
Breast Cancer 0.8 1.9 3.3 -0.4 -1.8 -1.0 -1.7 1.4 -1.6 1.2
Ovarian Cancer 0.5 0.7 1.6 1.3 0.9 0.8 0.1 0.0 0.8 -1.2
Prostate Cancer 6.8 9.8 14.6 -2.6 -3.8 -3.3 -3.3 -0.7 -3.7 3.3
Age at First Birth 3.5 5.1 10.0 2.4 2.5 3.2 2.2 -0.2 2.5 -1.6
Bipolar Disorder 3.9 3.9 5.9 -2.4 -1.8 -2.3 -1.8 -2.0 -2.1 1.1
Body Mass Index (BMI) (2010) 0.8 1.2 1.8 -1.2 -1.2 -1.4 -1.1 -0.1 -1.2 0.8
Coronary Artery Disease (CAD) 0.2 0.2 1.0 1.0 -0.0 0.3 -0.3 -0.4 0.1 -0.2
Crohns Disease (2012) 0.6 0.9 1.6 -0.7 -0.9 -1.1 -1.3 -0.7 -0.9 1.1
Mean Putamen Volume 0.3 0.3 0.6 -0.1 -0.7 -0.7 -0.3 -0.4 -0.8 0.6
Fasting Glucose 0.1 0.2 0.3 0.0 0.5 0.5 0.4 0.3 0.4 -0.5
HbA1C 1.8 2.0 4.1 -0.8 -1.5 -1.2 -1.7 -1.0 -1.5 2.0
HDL Cholesterol 0.3 0.5 1.8 -0.2 0.5 0.6 0.6 -1.4 0.5 -0.5
LDL Cholesterol 0.3 0.5 3.0 0.3 -0.1 -0.3 0.1 1.7 -0.1 -0.3
Lupus 0.8 1.1 2.2 -1.5 -1.3 -0.3 -0.9 -1.2 -1.0 0.9
Neuroticism 0.5 0.7 1.1 1.1 0.8 0.3 1.1 0.3 0.8 -1.0
Primary Biliary Cirrhosis 0.6 0.9 2.3 0.3 0.9 0.9 0.8 -1.5 0.7 -0.9
Rheumatoid Arthritis 1.4 1.9 3.4 -0.2 1.8 1.5 1.3 -1.4 1.6 -1.3
Schizophrenia 10.6 23.5 42.1 -4.2 -5.3 -6.5 -5.5 -1.4 -5.6 3.6
Triglycerides 0.1 0.2 0.4 0.6 -0.3 -0.3 -0.4 0.1 -0.3 0.5
Type 2 Diabetes (T2D) 0.5 0.5 1.7 -0.4 0.5 0.5 0.8 -0.5 0.8 -1.3
Ulcerative Colitis 0.6 0.9 2.3 0.0 1.2 0.9 0.4 -0.6 1.0 -1.5
Blood Eosinophil Count 1.3 10.4 17.7 -4.2 -3.5 -4.0 -2.9 -1.5 -3.4 2.3
Blood Platelet Count 0.1 1.1 4.7 -2.2 -0.9 -0.0 -0.4 -1.1 -0.8 0.1
Blood Red Count 1.3 13.2 19.1 -4.4 -3.3 -3.6 -3.2 -4.2 -3.4 3.2
Blood White Count 2.8 20.5 43.3 -6.6 -4.0 -5.4 -3.8 -3.5 -4.3 3.2
Heel T-Score 5.1 40.6 51.8 -7.2 -6.8 -6.3 -7.2 -4.0 -6.9 5.6
BMI 4.5 26.8 37.5 -6.1 -5.5 -6.1 -5.3 -1.5 -5.4 4.8
Height 1.2 23.0 44.3 4.7 5.3 6.7 4.2 3.7 5.0 -3.2
Waist Hip Ratio (WHR) 0.1 0.4 0.9 -0.9 -0.4 -0.5 -0.4 -1.0 -0.4 0.2
Systolic Blood Pressure 0.2 1.0 3.4 1.8 -0.4 -0.3 -0.4 -1.7 -0.2 -0.3
Smoking Status 11.1 26.8 34.7 -4.5 -5.7 -5.7 -5.9 -3.8 -5.9 4.3
Allergy or Eczema 1.0 2.5 3.3 1.7 1.3 1.7 1.7 1.8 1.5 -1.5
Cardiovascular Disease 4.7 15.6 23.9 -3.0 -4.6 -4.9 -4.7 -1.7 -4.6 3.2
Hypothyroidism (self reported) 0.1 0.3 0.9 0.2 -0.7 -0.9 -0.4 0.3 -0.7 0.2
Respiratory disease 1.7 3.7 5.5 -2.3 -2.0 -1.8 -2.0 -1.0 -2.1 2.0
Type 2 Diabetes (T2D) 0.9 1.7 4.2 -2.1 -1.0 -1.5 -1.5 -0.4 -1.2 0.1
Lung FEV1/FVC ratio 1.4 7.0 9.7 2.3 2.8 2.6 3.0 0.4 3.1 -3.1
Lung FVC 0.5 2.4 4.6 -1.4 -1.3 -0.9 -2.1 -1.6 -1.6 1.6
Neuroticism 0.0 0.1 0.3 0.3 0.1 -0.5 -0.3 -0.1 -0.0 -0.1
Chronotype (morning person) 0.4 0.9 1.7 -0.5 1.3 1.1 1.1 0.3 1.0 -1.1
Hair Pigment 1.3 39.4 53.3 -6.4 -6.9 -7.3 -6.3 -3.0 -6.9 6.1
Tanning 0.0 0.6 1.0 -0.6 -1.0 -0.5 -0.8 -0.2 -1.0 0.9
Hand grip strength (left) 0.1 0.4 1.3 0.0 -0.6 -1.1 -0.6 -0.2 -0.5 0.5
Number of treatments/medications taken 2.0 3.6 5.4 1.1 2.3 1.9 2.0 -0.9 2.2 -2.3
Average weekly spirits intake 0.8 1.0 3.2 0.9 0.5 -0.3 1.3 1.8 0.7 -0.7
Sensitivity / hurt feelings 0.7 1.2 2.4 -0.1 -1.1 -0.5 -1.1 1.4 -1.1 1.6
Frequency of depressed mood in last 2 weeks 3.7 5.2 7.9 2.8 2.6 2.8 2.3 0.6 2.5 -1.5
Hearing difficulty/problems: Yes 6.4 9.7 15.1 1.5 3.7 3.8 3.9 0.2 3.7 -3.0
Relative age of first facial hair 4.1 8.6 12.1 3.0 2.6 3.0 3.0 3.5 2.8 -2.6
Other serious medical condition/disability diagnosed by doctor 4.2 5.5 9.3 1.5 2.8 3.1 2.6 0.2 2.7 -2.2
Ever used hormone-replacement therapy (HRT) 0.9 1.2 2.2 0.3 1.2 0.4 1.4 0.8 1.4 -1.5
Ever had hysterectomy (womb removed) 0.3 0.3 0.7 -0.8 -0.6 -0.8 0.1 -0.3 -0.4 0.2
Systolic blood pressure, automated reading 0.3 0.8 3.2 -1.8 -0.5 -0.4 -0.6 0.5 -0.6 1.0
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 2.0 1.4 0.5 0.8 0.9 -0.6 0.6 0.3
Angina 0.6 0.8 1.8 0.7 1.2 1.3 0.8 0.4 1.0 -0.4
Medication for hormone replacement therapy 0.8 0.9 1.5 -0.6 -1.2 -1.1 -1.0 -0.5 -1.1 0.8
Vitamin and mineral supplements 0.6 0.8 1.5 -0.3 0.7 0.8 1.2 1.2 0.9 -0.7
Supplements: Zinc 0.2 0.2 0.8 -0.1 -0.3 -0.0 -0.7 0.9 -0.4 0.1
Medication: Co-codamol 0.5 0.6 2.4 0.4 0.6 0.5 0.6 0.4 0.6 -1.6
Medication: Metformin 0.1 0.2 0.6 0.8 -0.2 0.1 0.5 -0.6 -0.1 0.4
Diabetes (father) 0.1 0.1 0.2 0.2 -0.1 -0.1 -0.5 0.4 -0.3 0.4
Diabetes (mother) 0.3 0.4 1.6 0.8 0.1 0.6 0.0 1.3 0.1 0.3
Severe depression (siblings) 0.8 0.8 1.3 0.1 1.0 1.1 1.0 0.7 1.0 -1.1
Pack years adult smoking proportion 8.9 13.6 17.8 3.8 4.0 4.2 4.2 0.1 4.1 -3.5
Impedance of leg (right) 3.8 18.9 25.7 -4.2 -4.8 -5.1 -4.5 1.3 -4.6 4.7
Leg fat-free mass (left) 1.4 7.7 10.2 3.2 2.8 3.1 2.9 -0.7 2.8 -3.0
Trunk fat percentage 1.2 4.9 7.5 2.5 2.4 2.7 2.3 1.4 2.2 -1.7
Hand grip strength (right) 0.1 0.2 0.7 0.0 -0.3 -0.9 -0.2 0.8 -0.2 0.3
Townsend deprivation index at recruitment 3.4 4.8 7.8 2.5 1.9 2.8 1.9 2.3 2.0 -1.8
Current tobacco smoking 14.0 22.8 29.2 5.4 4.8 4.9 4.9 3.5 5.0 -4.7
Average weekly fortified wine intake 0.1 0.1 0.5 0.0 -0.0 -0.1 0.3 -0.7 0.2 -0.0
Maternal smoking around birth 10.0 14.5 17.8 3.5 4.2 4.2 3.8 3.0 4.2 -3.6
Fed-up feelings 0.7 1.3 3.0 1.7 1.1 1.3 0.8 0.1 1.1 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.7 4.7 1.0 2.2 2.0 1.2 -0.9 1.8 -1.8
Relative age voice broke 0.4 0.6 3.0 0.9 0.2 0.5 0.1 1.7 0.3 0.0
Taking other prescription medications 2.4 3.7 5.8 1.7 2.4 2.3 1.7 -0.7 2.2 -1.8
Age when periods started (menarche) 0.5 1.2 3.3 1.5 1.1 1.8 0.5 0.5 0.9 -0.4
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 2.3 -1.5 -0.7 -1.0 -0.2 -0.0 -0.6 0.6
Heel bone mineral density (BMD) T-score, automated (left) 2.9 6.5 11.9 1.5 3.0 3.1 3.5 0.5 3.1 -1.6
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 1.9 -1.4 -0.9 -1.1 -0.9 -0.6 -0.9 0.2
Qualifications: CSEs or equivalent 0.3 0.4 0.7 0.5 0.8 0.5 0.7 -0.1 0.7 -0.9
Serious illness, injury or assault to yourself 2.0 2.4 3.7 1.8 1.5 1.9 1.7 -0.5 1.6 -1.4
High blood pressure 2.3 6.4 11.5 1.2 3.0 3.4 3.0 1.5 2.9 -1.9
Hayfever, allergic rhinitis or eczema 1.1 2.3 3.9 -1.5 -1.2 -1.6 -1.5 -2.0 -1.3 1.4
Multivitamins +/- minerals 0.2 0.3 0.8 0.0 -0.2 -0.5 -0.9 -0.7 -0.5 0.4
Stomach or abdominal pain in last month 3.2 4.0 7.6 1.6 2.4 2.8 1.7 -0.5 2.2 -2.0
Supplements: Glucosamine 2.9 3.7 6.3 -1.4 -2.1 -2.3 -1.4 -2.5 -2.0 1.5
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.7 0.3 0.7 0.6 0.5 0.8 0.6 -0.2
Medication: Atenolol 1.7 2.1 3.3 1.1 1.4 1.8 1.3 -1.7 1.4 -1.2
Medication: Levothyroxine sodium 0.5 0.9 3.4 -1.5 0.5 0.2 -0.2 -1.8 0.2 -0.2
Sitting height 0.1 0.8 2.4 -0.5 -1.0 -1.6 -0.5 -0.6 -0.9 0.5
Chronic bronchitis/emphysema (father) 0.2 0.2 0.6 -0.0 0.5 0.7 0.5 0.8 0.5 0.0
High blood pressure (mother) 0.5 0.7 2.7 -0.5 -0.4 0.0 -1.0 -0.1 -0.7 1.6
Body mass index (BMI) 3.7 16.2 26.4 4.4 4.4 5.1 4.0 1.0 4.2 -3.6
Impedance of leg (left) 3.5 17.4 23.5 -4.2 -4.5 -4.9 -4.2 1.9 -4.4 4.4
Leg predicted mass (left) 1.4 7.3 9.5 3.1 2.8 3.0 2.9 -0.8 2.8 -3.0
Trunk fat mass 1.2 5.5 7.8 2.7 2.5 2.8 2.5 1.0 2.4 -2.1
Waist circumference 3.3 12.5 19.3 3.9 3.9 4.4 3.5 0.6 3.7 -3.4
Number of incorrect matches in round 0.8 1.3 3.6 -0.6 -1.0 -1.9 -0.9 -0.6 -1.0 1.3
Past tobacco smoking 5.4 10.1 13.8 -2.5 -3.7 -3.7 -3.3 -2.9 -3.7 2.1
Alcohol usually taken with meals 0.5 0.8 2.0 -0.2 -1.0 -1.2 -0.6 -1.4 -0.7 0.7
Nervous feelings 1.4 2.7 4.6 -2.1 -1.8 -1.4 -1.5 -1.3 -1.8 1.2
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.1 5.2 2.2 1.7 2.3 1.8 0.4 1.8 -1.6
Hearing difficulty/problems with background noise 6.7 10.8 19.0 2.5 3.4 3.9 4.4 1.1 3.7 -2.9
Hair/balding pattern: Pattern 2 4.4 5.6 8.0 2.8 2.7 2.0 2.2 1.4 2.6 -2.5
Had menopause 0.5 0.6 1.0 0.2 1.0 0.6 1.0 -0.5 0.9 -1.0
Had other major operations 0.7 0.9 2.4 0.2 0.8 1.2 0.5 1.5 0.7 -1.1
Forced vital capacity (FVC) 0.1 0.4 1.1 0.8 -0.1 -0.3 0.5 1.1 0.2 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.2 5.6 1.4 2.1 2.1 2.4 1.1 2.1 -0.7
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.8 1.3 0.4 0.8 0.6 -0.3 0.5 -0.9
Qualifications: None of the above 1.9 4.2 6.3 -1.1 -2.3 -2.2 -2.5 0.7 -2.4 2.2
Financial difficulties in last 2 years 14.0 19.0 28.3 4.0 4.9 5.3 4.6 1.1 5.0 -4.2
Mouth/teeth dental problems 9.8 15.0 20.4 -3.1 -4.5 -4.4 -4.5 -1.2 -4.5 3.8
Heart attack 1.1 1.4 2.4 1.3 1.1 1.4 0.5 1.6 0.9 -1.1
Allergy 0.5 1.2 3.1 1.2 0.7 1.1 0.8 1.8 0.8 -0.9
Pain all over the body in last month 0.5 0.5 1.2 -1.1 0.7 0.7 0.4 -0.4 0.6 -0.7
Diabetes (self-reported) 0.9 1.4 3.2 1.3 1.1 1.3 1.8 0.0 1.2 -0.6
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 1.1 -0.0 -0.4 -1.0 -0.1 0.4 -0.2 0.4
Medication: Ramipril 1.0 1.2 3.7 1.0 0.9 1.0 0.8 1.9 0.8 -1.0
Medication: Simvastatin 0.3 0.4 2.6 0.0 0.3 0.4 0.2 -1.6 0.1 -0.4
Fluid intelligence score 4.1 8.7 13.5 3.7 2.9 2.8 3.0 0.9 3.0 -3.4
Illnesses of siblings 3.0 4.2 7.5 -2.7 -2.1 -2.0 -1.9 -1.1 -2.1 2.1
Neuroticism score 0.0 0.1 0.3 -0.4 -0.1 0.5 0.0 -0.1 -0.1 0.2
Weight 1.5 7.6 10.5 3.2 2.9 3.2 2.9 0.4 2.8 -2.7
Impedance of arm (right) 1.2 5.5 8.4 -1.9 -2.6 -2.9 -2.5 1.5 -2.4 2.3
Arm fat percentage (right) 3.9 15.8 23.4 4.5 4.3 4.8 3.9 2.0 4.1 -3.6
Trunk fat-free mass 0.4 2.3 3.7 1.8 1.3 1.4 1.5 -1.2 1.3 -1.9
Hip circumference 2.0 9.0 14.6 3.5 3.2 3.8 3.0 0.0 3.1 -2.8
Time employed in main current job 1.2 1.4 3.0 -1.3 -1.1 -1.7 -1.2 -0.6 -1.2 0.8
Alcohol intake versus 10 years previously 0.8 1.1 3.2 0.8 1.1 0.9 0.4 1.8 0.8 -1.2
Father’s age at death 0.7 0.9 1.7 0.9 -1.3 -0.5 -0.6 -0.9 -1.0 1.3
Worrier / anxious feelings 0.1 0.1 0.5 -0.4 0.1 0.1 -0.0 0.7 0.0 0.6
Frequency of tiredness / lethargy in last 2 weeks 7.8 12.8 17.4 3.5 3.9 4.2 3.5 2.1 3.9 -3.6
Falls in the last year 0.3 0.4 1.3 -0.5 0.2 0.8 -0.2 -0.9 -0.1 -1.1
Hair/balding pattern: Pattern 3 3.2 4.8 8.3 -2.9 -2.4 -1.8 -1.9 -1.7 -2.3 2.1
Number of live births 1.4 1.9 13.3 0.3 -0.0 0.1 -0.1 3.6 0.0 -0.3
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 3.0 -0.3 -1.7 -1.7 -1.1 0.7 -1.5 0.9
Pulse rate 1.4 2.4 3.8 0.6 1.7 1.9 1.2 1.6 1.5 -1.8
Happiness 0.3 0.4 1.1 -0.6 0.2 1.1 -0.5 -0.9 0.0 -0.4
Noisy workplace 0.5 0.7 1.2 -0.1 0.8 1.0 0.8 0.7 0.8 -1.1
Qualifications: A levels/AS levels or equivalent 2.3 5.2 7.7 1.9 2.4 2.6 2.8 0.7 2.7 -2.2
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 1.7 -1.1 -1.1 -0.7 -0.8 0.1 -1.0 1.3
Mouth/teeth dental problems: Dentures 2.4 4.0 6.5 1.3 2.3 1.9 2.5 1.4 2.4 -1.9
Asthma 0.6 1.1 1.9 1.4 1.1 0.7 1.3 0.1 1.2 -1.0
Medication: Ibuprofen (e.g. Nurofen) 3.5 4.5 6.3 1.7 2.4 2.1 2.5 0.5 2.4 -2.4
Medication: Cholesterol lowering 0.4 0.7 2.1 0.6 0.8 0.4 0.6 -1.4 0.6 -0.9
Depression (self-reported) 0.4 0.4 1.7 1.3 0.2 0.7 0.0 0.9 0.2 0.3
Medication: Lansoprazole 0.1 0.1 0.3 0.3 -0.1 0.2 0.1 0.6 0.1 0.2
Prospective memory result 1.2 1.4 2.7 -1.4 -1.2 -1.6 -0.8 0.7 -1.2 1.1
Lung cancer (father) 4.0 4.7 11.1 2.2 1.8 2.0 1.9 3.3 1.9 -1.6
Illnesses of mother 0.7 0.8 1.4 -1.1 -1.2 -1.2 -0.4 -0.8 -0.9 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.7 0.5 -0.8 -0.9 -0.3 0.1 -0.6 0.3
Pulse wave Arterial Stiffness index 2.9 3.4 7.1 2.7 1.8 2.1 1.6 1.2 1.8 -1.5
Impedance of arm (left) 1.7 7.9 11.6 -2.4 -3.1 -3.4 -2.9 1.1 -3.0 3.0
Arm fat mass (right) 3.4 14.3 20.8 4.2 4.1 4.6 3.8 1.2 3.9 -3.6
Trunk predicted mass 0.4 2.3 3.7 1.8 1.3 1.4 1.5 -1.2 1.3 -1.9
Standing height 0.5 4.7 10.7 -1.9 -2.6 -3.3 -1.9 -1.3 -2.3 1.2
Length of working week for main job 0.4 0.4 1.5 1.1 -0.2 -0.1 0.0 1.2 -0.2 0.2
Exposure to tobacco smoke at home 4.4 4.9 7.8 1.5 2.6 2.8 2.4 -0.5 2.6 -2.3
Breastfed as a baby 2.0 2.4 4.4 -0.9 -2.1 -1.9 -1.2 0.6 -1.8 1.7
Tense / ‘highly strung’ 0.3 0.5 2.5 -0.9 -0.2 0.3 -0.2 -1.6 -0.2 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 3.2 4.9 10.0 2.0 2.2 3.2 1.8 2.1 2.2 -1.9
Hair/balding pattern: Pattern 4 0.3 0.7 1.4 1.0 0.4 1.2 0.9 0.8 0.6 -0.7
Birth weight of first child 1.1 2.0 3.4 1.9 1.4 1.4 1.0 0.9 1.4 -1.8
Peak expiratory flow (PEF) 0.5 1.3 1.7 0.6 -1.2 -1.3 -1.3 0.9 -1.2 1.1
Pulse wave reflection index 0.5 0.6 1.6 1.3 0.7 0.6 0.8 0.4 0.8 -0.5
Ever highly irritable/argumentative for 2 days 1.0 1.1 2.8 0.1 1.1 1.7 0.9 -0.7 1.1 -1.1
Loud music exposure frequency 0.4 0.5 0.8 0.5 0.7 0.9 0.9 0.4 0.7 -0.6
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.0 1.0 1.1 0.9 1.4 0.0 1.2 -0.5
Mouth/teeth dental problems: Bleeding gums 3.6 4.6 6.4 2.0 2.3 2.5 2.5 1.0 2.4 -1.9
Blood clot in the leg (DVT) 0.1 0.2 0.5 -0.3 0.2 0.2 0.7 -0.6 0.3 -0.5
Medication: Paracetamol 4.5 7.6 10.0 2.6 3.2 3.0 2.9 0.8 3.1 -3.0
Headache pain in last month 2.4 4.3 5.9 2.4 2.3 2.2 1.9 -1.1 2.3 -2.1
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 1.9 -0.1 -1.4 -1.1 -1.2 0.8 -1.2 1.4
Glaucoma (self-reported) 2.5 2.9 4.3 -0.8 -2.0 -1.7 -2.1 -0.6 -1.9 2.1
Gout (self-reported) 1.9 2.7 4.0 1.5 2.0 1.7 1.7 -0.1 2.0 -1.6
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.9 -0.7 0.4 0.5 0.1 -1.0 0.3 0.1
Medication: Amlodipine 2.2 3.1 9.0 -3.0 -1.4 -1.6 -0.9 -1.7 -1.4 1.7
Medication: Ventolin 100micrograms inhaler 0.2 0.3 1.1 -0.3 0.0 -0.1 -0.5 -1.0 -0.2 0.8
Birth weight 0.6 1.4 1.9 -0.6 -1.3 -1.3 -1.4 -1.4 -1.3 0.8
Chronic bronchitis/emphysema (mother) 0.5 0.6 0.9 0.9 0.9 0.8 0.7 0.2 0.9 -0.6
High blood pressure (siblings) 3.2 4.7 8.8 3.0 2.1 2.0 1.9 2.3 2.1 -1.5
Forced vital capacity (FVC), Best measure 0.2 0.7 1.8 1.4 0.5 0.2 1.0 0.5 0.8 -1.0
Body fat percentage 1.4 5.6 8.6 2.6 2.5 2.9 2.4 1.9 2.4 -1.8
Leg fat percentage (right) 1.0 3.5 5.7 2.2 1.9 2.4 1.7 1.8 1.7 -1.1
Arm fat-free mass (right) 0.4 1.9 2.7 1.5 1.2 1.3 1.4 -1.3 1.2 -1.7
Exposure to tobacco smoke outside home 1.2 1.6 4.7 1.8 1.2 2.2 0.8 0.2 1.2 -0.4
Comparative body size at age 10 0.1 0.3 1.2 1.1 -0.2 -0.3 -0.3 -0.5 -0.1 0.6
Number of full brothers 2.4 3.0 5.0 1.4 1.5 1.8 2.0 2.2 1.8 -1.1
Worry too long after embarrassment 1.1 1.9 6.4 -2.5 -0.8 -1.0 -0.6 -2.0 -0.8 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 4.3 5.6 10.9 1.3 2.5 3.3 2.4 0.4 2.5 -2.8
Wheeze or whistling in the chest in last year 1.7 3.0 3.8 1.9 1.8 1.9 1.8 0.8 1.8 -1.8
Number of children fathered 1.3 1.5 2.8 0.6 1.3 0.8 1.7 1.0 1.4 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 3.4 -1.9 -0.6 -0.6 -0.4 -0.4 -0.5 1.0
Age at first live birth 1.2 2.2 3.3 -1.8 -1.5 -1.7 -1.1 1.2 -1.5 1.4
Pulse wave peak to peak time 3.5 4.1 8.0 -2.8 -2.0 -2.4 -1.8 -1.2 -2.0 1.6
Health satisfaction 3.5 4.5 8.2 1.5 2.4 2.9 1.9 -0.2 2.2 -2.7
Shortness of breath walking on level ground 0.7 0.9 2.5 -0.3 1.0 1.1 0.8 0.3 0.7 -1.6
Qualifications: College or University degree 3.3 10.5 16.3 2.1 3.2 3.6 4.0 -0.0 3.7 -4.0
Eye problems/disorders: None of the above 0.3 0.4 2.1 -0.2 0.3 0.3 0.4 1.4 0.3 -0.3
Mouth/teeth dental problems: Loose teeth 7.5 8.8 11.4 2.9 3.4 3.3 3.0 -0.2 3.4 -3.3
Emphysema/chronic bronchitis 5.8 6.6 8.4 2.2 2.8 2.9 2.7 0.6 2.9 -2.9
Medication for pain relief, constipation, heartburn 3.4 5.9 8.7 -1.8 -2.9 -2.7 -2.8 0.7 -2.8 2.3
Neck or shoulder pain in last month 4.0 5.7 10.0 2.1 2.6 2.6 2.3 0.7 2.5 -3.2
Medication: Blood pressure 0.4 0.7 1.0 -0.8 1.0 0.7 0.9 -0.3 0.9 -0.9
Angina (self-reported) 0.4 0.6 1.5 0.4 1.0 1.2 0.7 0.3 0.9 -0.3
Migraine (self-reported) 0.4 0.5 1.4 -0.3 -0.4 -1.2 -0.5 -1.2 -0.4 0.1
Medication: Ibuprofen 1.8 2.1 2.9 1.4 1.7 1.5 1.6 0.3 1.6 -1.6
Medication: Allopurinol 2.4 3.2 4.9 1.1 2.0 1.7 2.2 -1.5 2.0 -1.8
Medication: Omeprazole 1.3 1.5 5.3 -1.8 -0.3 -0.7 -0.5 -2.3 -0.6 0.9
Medication: Seretide 50 evohaler 0.5 0.5 2.1 -1.1 0.4 -0.1 0.4 -1.5 0.3 0.2
Mean time to correctly identify matches 0.1 0.2 0.7 0.6 -0.3 -0.0 0.0 0.9 -0.2 0.4
Heart disease (mother) 2.5 3.1 5.1 2.3 2.1 1.9 1.5 0.8 2.0 -1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.9 -0.7 -0.7 -1.1 -1.4 0.4 -1.0 0.6
Whole body fat mass 1.6 7.1 10.6 3.0 2.8 3.3 2.6 1.5 2.7 -2.3
Leg fat mass (right) 1.5 5.9 9.2 2.8 2.5 3.0 2.4 1.6 2.4 -2.0
Arm predicted mass (right) 0.6 3.0 4.5 1.8 1.6 1.7 1.9 -1.2 1.6 -2.1
Pulse rate, automated reading 2.4 7.9 12.6 1.6 3.3 3.5 2.8 2.2 3.2 -2.5
Alcohol intake frequency. 0.3 0.7 3.3 1.8 0.5 0.5 0.3 -0.4 0.5 -0.7
Comparative height size at age 10 1.2 6.6 12.2 -2.8 -2.6 -3.5 -2.2 -2.1 -2.6 1.7
Number of full sisters 0.4 0.5 0.9 -0.5 0.7 0.9 0.6 0.2 0.7 -0.9
Suffer from ‘nerves’ 1.0 1.5 3.8 -1.9 -1.1 -1.0 -0.8 -1.7 -1.1 0.5
Overall health rating 4.2 9.1 14.7 2.6 3.6 3.8 3.0 0.4 3.3 -2.9
Chest pain or discomfort 1.4 2.0 2.5 0.9 1.4 1.5 1.6 1.6 1.4 -1.5
Had major operations 1.5 1.8 3.3 1.4 1.4 1.5 1.2 -0.2 1.3 -1.8
Age at last live birth 1.3 1.9 10.6 -0.3 -0.8 -0.5 -0.6 3.3 -0.7 0.9
Family relationship satisfaction 0.5 0.6 1.3 -1.1 0.5 0.8 0.2 -1.0 0.5 -1.1
Leg pain on walking 1.5 1.9 4.1 0.6 1.3 1.4 1.8 0.5 1.4 -2.0
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.4 2.6 -0.8 1.2 1.2 1.4 0.0 1.1 -1.6
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 -0.0 0.4 0.3 -0.2 -0.2 0.1 0.4
Illness, injury, bereavement, stress in last 2 years 7.9 9.7 16.1 -2.3 -3.5 -4.0 -3.5 0.2 -3.6 3.1
Medication: Aspirin 0.5 0.7 2.3 0.8 0.6 0.9 0.6 -1.5 0.5 -0.2
Supplements: Vitamin C 4.8 5.7 7.1 -1.0 -2.5 -2.4 -2.7 -2.7 -2.6 2.5
Knee pain experienced in last month 1.1 1.7 2.9 1.6 1.2 1.2 1.3 0.9 1.2 -1.7
Hypertension (Self-reported) 2.1 6.0 12.2 0.9 3.0 3.5 3.0 0.4 2.8 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 2.7 -0.5 0.6 0.6 0.1 -1.6 0.4 -0.5
Illnesses of father: Heart disease 2.9 4.0 7.7 -0.7 -1.9 -1.7 -2.0 -2.8 -1.9 2.4
Illnesses of siblings: Diabetes 0.8 1.0 2.7 1.6 0.6 0.6 0.7 1.3 0.6 -1.1
Smoking status: Previous 1.1 1.7 2.9 0.3 1.7 1.6 1.1 1.6 1.6 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 1.6 -0.2 -1.0 -1.1 -1.3 0.7 -0.9 0.5
Whole body fat-free mass 0.6 3.7 5.4 2.1 1.8 2.0 2.0 -1.3 1.8 -2.3
Leg fat-free mass (right) 1.4 7.8 9.7 3.1 2.9 3.1 3.0 -0.8 2.9 -3.1
Arm fat percentage (left) 2.9 11.9 18.7 3.9 3.7 4.3 3.4 1.8 3.5 -3.0
Average weekly red wine intake 0.5 0.7 2.0 0.1 0.8 0.6 1.4 0.0 1.0 -1.0
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.6 1.3 0.5 -0.2 -0.2 0.4 0.3 -1.0
Mood swings 1.4 2.5 4.8 1.8 1.6 2.2 1.4 0.6 1.5 -1.5
Loneliness, isolation 2.9 4.0 6.9 2.6 1.9 2.3 2.0 1.0 2.1 -1.6
Long-standing illness, disability or infirmity 7.2 11.2 15.3 2.8 3.6 3.9 3.8 0.9 3.7 -3.7
Ever had bowel cancer screening 1.1 1.3 2.0 0.7 1.1 0.8 1.3 1.4 1.2 -1.1
Diabetes diagnosed by doctor 1.1 1.9 4.1 1.6 1.2 1.6 2.0 -0.3 1.4 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 3.3 3.5 5.0 -0.1 2.2 2.1 2.1 1.2 2.2 -2.2
Friendships satisfaction 0.4 0.5 2.0 -0.2 0.5 0.9 0.2 -1.4 0.5 -0.3
Qualifications: nursing, teaching 2.0 3.1 6.8 2.6 1.4 1.4 2.1 1.2 1.8 -1.4
Commuting to job workplace: Walk 0.2 0.2 0.7 0.3 -0.5 0.6 -0.3 -0.3 -0.3 0.8
Eye problems/disorders: Cataract 0.1 0.1 0.3 0.4 0.0 0.0 0.0 -0.6 -0.1 0.4
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.5 -0.5 0.4 0.7 -0.0 -0.1 0.2 0.1
Medication for cholesterol 2.3 3.6 5.5 -1.5 -2.1 -2.3 -2.2 0.6 -2.1 1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.3 0.5 0.3 0.1 -0.4 -0.2 0.1 -0.6
Back pain experienced in last month 3.8 5.6 6.7 2.5 2.4 2.6 2.5 1.3 2.5 -2.5
Mineral and other dietary supplements 3.4 4.5 10.0 1.9 2.0 2.1 1.8 3.2 2.1 -1.6
Breast cancer (self-reported) 0.4 0.5 2.5 0.1 -0.5 -0.5 -0.4 1.6 -0.6 -0.4
Asthma (self-reported) 0.5 1.0 1.5 1.2 1.0 0.7 1.2 -0.2 1.1 -1.0
Osteoporosis (self-reported) 0.1 0.2 0.4 -0.6 -0.4 -0.1 -0.4 -0.3 -0.4 0.6
Osteoarthritis (self-reported) 1.3 1.7 4.0 2.0 1.1 1.5 1.1 0.1 1.2 -1.4
Medication: Aspirin 0.5 0.7 3.0 0.8 0.4 0.8 0.4 -1.7 0.3 0.2
Medication: Gliclazide 0.9 1.0 1.9 1.4 0.8 1.3 0.8 -1.1 0.8 -0.4
Illnesses of father: None of the above (group 1) 0.3 0.3 0.9 0.0 -0.6 -0.6 -0.4 1.0 -0.5 0.2
Smoking status: Current 12.1 19.1 22.1 4.7 4.4 4.5 4.6 3.2 4.7 -4.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.1 -0.8 -1.1 -1.4 -0.8 0.5 -1.0 0.5
Whole body water mass 0.7 4.3 6.0 2.4 1.9 2.1 2.1 -1.2 1.9 -2.4
Leg predicted mass (right) 1.4 7.5 9.7 3.1 2.8 3.0 2.9 -0.7 2.8 -3.0
Arm fat mass (left) 2.9 12.4 19.1 4.1 3.8 4.4 3.5 1.1 3.6 -3.2
Number of self-reported non-cancer illnesses 4.2 7.2 10.0 2.6 3.1 3.2 2.9 1.6 3.1 -2.0
Average weekly champagne plus white wine intake 3.4 4.7 7.1 2.7 2.1 2.2 2.4 1.4 2.4 -1.9
Miserableness 1.2 2.1 3.5 1.1 1.3 1.6 1.1 1.9 1.3 -1.7
Guilty feelings 0.2 0.4 1.1 -0.6 -0.8 0.1 -0.0 -0.1 -0.6 1.1
Wears glasses or contact lenses 0.4 0.5 1.4 0.3 0.6 0.4 0.9 -0.2 0.8 -1.2
Ever taken oral contraceptive pill 1.7 1.9 6.3 1.2 1.1 1.3 0.9 2.5 1.0 -0.6
Hearing aid user 1.3 1.4 4.6 0.6 1.1 1.0 1.2 0.5 1.1 -2.1
Mother’s age at death 4.8 6.1 9.2 -2.6 -2.5 -3.0 -2.5 -1.9 -2.5 2.0
Financial situation satisfaction 3.5 4.4 7.6 1.6 2.2 2.7 2.1 -0.2 2.2 -2.5
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.8 1.3 -0.2 0.1 0.5 -0.9 0.1 -0.1
Commuting to job workplace: Public transport 0.6 0.7 1.6 1.1 0.4 0.5 0.7 0.8 0.6 -1.3
Eye problems/disorders: Glaucoma 1.0 1.2 2.2 -0.4 -1.4 -1.0 -1.5 -0.5 -1.3 1.1
Medication: Blood pressure 1.7 3.4 5.9 1.7 1.9 2.4 2.2 0.4 2.0 -1.5
Pain type(s) experienced in last month: Hip pain 8.2 10.4 14.4 2.6 3.8 3.7 3.4 0.5 3.6 -3.7
Supplements: Fish oil (including cod liver oil) 2.4 3.1 4.7 -1.8 -1.8 -2.2 -1.5 -2.0 -1.8 1.1
High cholesterol (Self-reported) 0.6 1.1 1.8 0.5 1.3 0.8 1.1 -1.2 1.2 -1.1
Medication: Bendroflumethiazide 0.3 0.5 1.2 0.5 0.5 0.7 1.1 0.7 0.6 -0.4
Medication: Paracetamol 2.9 4.5 6.0 2.2 2.5 2.2 2.2 0.5 2.4 -2.2
Medication: Lisinopril 0.9 1.2 2.5 0.3 1.3 1.6 1.1 -0.7 1.3 -0.7
Medication: Atorvastatin 0.9 1.1 1.8 1.3 1.2 1.1 0.9 0.8 1.2 -0.6
Illnesses of father: High blood pressure 1.7 2.1 3.3 1.2 1.7 1.8 1.6 0.3 1.7 -1.2
Alcohol drinker status: Never 2.0 2.4 4.9 -0.4 -2.2 -1.9 -1.8 -0.1 -2.2 0.7
Ever smoked 3.8 6.9 8.8 2.3 2.7 2.8 2.8 3.0 2.8 -1.9
Basal metabolic rate 0.9 5.1 6.8 2.6 2.2 2.4 2.4 -0.8 2.2 -2.5
Leg fat percentage (left) 1.3 4.8 7.3 2.3 2.3 2.7 2.1 2.1 2.1 -1.6
Arm fat-free mass (left) 0.9 4.8 7.5 2.7 2.1 2.3 2.2 -0.8 2.1 -2.5
Number of operations (self-reported) 1.5 2.2 5.0 0.3 1.7 1.6 1.6 0.2 1.6 -2.2
Average weekly beer plus cider intake 0.6 0.8 1.8 0.3 1.3 0.9 1.0 0.4 1.1 -0.9
Irritability 0.8 1.3 2.7 0.8 1.3 1.6 1.2 0.3 1.4 -0.8
Risk taking 15.1 22.2 27.0 4.9 4.9 4.9 5.0 3.4 5.2 -4.6
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.8 -0.7 -0.2 -0.9 0.0 -0.8 -0.1 0.7
Fractured/broken bones in last 5 years 0.8 1.0 2.0 -0.7 -1.0 -1.4 -0.4 -1.2 -1.0 0.9
Age started oral contraceptive pill 1.4 1.7 2.5 -0.4 -1.4 -1.3 -1.6 -0.9 -1.5 1.6
Diastolic blood pressure, automated reading 3.3 10.5 15.8 2.5 3.5 4.0 3.0 3.1 3.4 -2.9
Ever depressed for a whole week 5.1 6.3 8.4 2.4 2.7 2.9 2.6 -0.6 2.8 -2.8
Unable to work because of sickness or disability 4.6 6.0 9.7 1.9 2.6 2.4 3.1 0.5 2.8 -2.8
Commuting to job workplace: Cycle 0.9 1.1 1.8 -1.0 -0.9 -1.3 -0.8 -0.8 -1.0 1.3
Myopia 0.3 0.4 1.0 -0.6 -0.6 -0.4 -0.5 -1.0 -0.7 0.2
Vascular/heart problems diagnosed by doctor 3.2 8.9 16.0 -1.7 -3.5 -4.0 -3.3 -1.5 -3.4 2.4
Cholesterol lowering medication 0.5 0.7 1.5 0.6 1.2 1.0 0.7 -0.1 1.0 -0.6
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 4.1 -1.9 -0.1 -0.6 -0.4 -2.0 -0.4 1.0
Pain experienced in last month 2.1 3.6 5.4 -2.3 -2.0 -2.3 -1.3 -0.3 -1.8 2.3
Supplements: Calcium 0.4 0.4 2.1 0.0 0.3 0.4 -0.3 -1.4 0.2 -0.6
Basal cell carcinoma (self-reported) 2.5 3.0 4.7 1.1 1.9 1.8 2.1 0.3 2.0 -2.2
Heart attack/myocardial infarction (self-reported) 1.0 1.2 2.4 1.2 1.0 1.3 0.5 1.6 0.8 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.6 -0.3 0.2 0.2 0.7 -0.8 0.3 -0.4
Heart disease (siblings) 1.1 1.4 2.8 0.6 1.7 1.1 1.2 -0.2 1.4 -1.5
Alcohol drinker status: Previous 9.6 11.0 17.8 2.9 3.6 4.2 3.7 0.3 3.7 -3.2
Pack years of smoking 8.3 12.2 15.8 3.8 3.8 3.9 4.0 0.2 3.9 -3.2
Impedance of whole body 2.3 12.1 16.8 -3.4 -3.8 -4.1 -3.6 1.4 -3.7 3.6
Leg fat mass (left) 1.9 7.5 11.1 3.0 2.9 3.3 2.8 1.7 2.8 -2.3
Arm predicted mass (left) 0.9 4.9 7.0 2.6 2.2 2.4 2.3 -0.7 2.2 -2.5