Hub : Genes

PRIMA1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.07 0.030 0.01700 0.054 0.000 0.019 0.025 0.043 3.8e-07 3.6e-01 0.00190 0.00039 5.8e-06
2 GTEx Adipose Visceral Omentum 0.22 0.071 0.00360 0.101 NA 0.066 NA 0.058 6.9e-06 NA 0.00024 NA 5.8e-04
3 TCGA Ovarian Tumor 0.07 0.031 0.00041 0.025 0.024 0.017 NA 0.020 1.4e-03 1.8e-03 0.00710 NA 3.7e-03
4 TCGA Prostate Tumor 0.11 0.033 0.00023 0.010 0.033 0.005 NA 0.012 1.8e-02 3.7e-05 0.06600 NA 9.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Alzheimer’s Disease (in mother) 1.1 1.3 2.2 1.3 -1.5 0.2 1.1
Alzheimer’s Disease (in father) 0.6 0.6 2.3 -0.1 -1.5 -0.3 -0.0
Alzheimer’s Disease (including proxy) 0.6 0.9 2.0 1.0 -1.4 -0.4 0.4
Crohns Disease (2017) 0.1 0.3 0.6 -0.7 -0.5 -0.7 -0.0
Irritable Bowel Disease (IBD) 0.2 0.4 1.0 -0.3 0.6 -1.0 -0.4
Ulcerative Colitis (UC) 0.2 0.3 1.2 -0.2 1.1 -0.4 -0.1
Major Depression (MDD) 1.9 2.3 7.0 0.6 1.1 2.7 -0.8
Reaction Time 1.3 2.5 5.2 -1.7 -0.8 2.3 1.0
Verbal and Numeric Reasoning (VNR) 0.6 1.5 5.0 2.2 -0.0 -0.3 -1.0
Breast Cancer 0.1 0.2 0.6 -0.5 -0.8 0.2 0.3
Ovarian Cancer 0.2 0.3 1.1 -0.3 -0.3 -0.0 -1.0
Prostate Cancer 1.0 1.5 4.8 2.2 0.2 -0.3 -1.0
Age at First Birth 1.9 2.8 9.7 0.8 0.6 -3.1 -0.7
Bipolar Disorder 2.3 2.3 6.6 0.0 -0.9 -2.6 -1.3
Body Mass Index (BMI) (2010) 0.3 0.4 1.1 0.2 -0.4 0.4 -1.1
Coronary Artery Disease (CAD) 0.6 0.7 2.1 -0.0 -0.5 1.4 -0.8
Crohns Disease (2012) 0.5 0.9 2.5 1.6 0.7 0.7 0.3
Mean Putamen Volume 0.7 0.8 1.5 -1.2 0.6 -0.9 -0.9
Fasting Glucose 0.7 0.8 2.1 0.8 1.5 -0.5 0.4
HbA1C 1.4 1.5 3.4 1.3 -0.8 0.7 1.8
HDL Cholesterol 0.6 1.0 1.8 -1.2 0.9 -1.4 -0.3
LDL Cholesterol 0.2 0.3 0.6 -0.2 -0.7 -0.1 0.7
Lupus 0.7 1.1 1.9 1.4 0.8 0.8 -1.1
Neuroticism 1.7 2.4 8.9 -3.0 0.6 0.5 0.5
Primary Biliary Cirrhosis 1.2 1.8 3.2 0.7 -1.0 -1.8 1.5
Rheumatoid Arthritis 0.5 0.7 2.6 1.6 0.1 -0.2 -0.2
Schizophrenia 1.4 3.1 5.2 -1.4 -1.7 -2.3 1.5
Triglycerides 0.5 0.8 1.6 0.3 0.9 -0.8 1.3
Type 2 Diabetes (T2D) 0.6 0.8 2.4 -0.6 -1.5 -0.1 -0.6
Ulcerative Colitis 1.1 1.5 4.3 0.2 -2.1 0.6 1.2
Blood Eosinophil Count 1.3 10.0 34.1 1.3 -5.8 0.1 2.0
Blood Platelet Count 0.5 6.0 18.5 -0.9 -0.9 4.3 -2.0
Blood Red Count 0.1 1.0 1.9 -1.4 -0.7 1.0 0.8
Blood White Count 0.6 4.6 17.2 0.2 -1.0 4.1 -0.5
Heel T-Score 0.6 4.8 8.6 -2.9 2.5 -1.9 0.9
BMI 4.2 24.9 87.2 2.1 -2.5 9.3 1.3
Height 0.1 1.9 3.2 -1.4 -1.4 -0.9 1.8
Waist Hip Ratio (WHR) 0.1 0.6 1.3 0.3 0.8 -1.2 0.5
Systolic Blood Pressure 0.3 1.7 4.1 0.3 -1.0 1.4 -2.0
Smoking Status 1.1 2.7 7.0 1.3 1.4 2.7 -0.2
Allergy or Eczema 0.8 2.0 3.6 -1.8 1.1 0.0 -1.9
Cardiovascular Disease 1.8 6.1 10.8 1.6 -3.2 3.3 -0.6
Hypothyroidism (self reported) 0.6 1.4 2.9 1.7 -1.2 0.9 0.7
Respiratory disease 1.2 2.6 6.7 -1.2 1.4 2.6 -0.4
Type 2 Diabetes (T2D) 0.2 0.4 1.3 -0.6 -0.2 1.1 0.0
Lung FEV1/FVC ratio 1.0 5.2 19.4 0.0 -4.4 -1.1 -0.6
Lung FVC 1.1 5.7 20.0 1.0 0.7 -4.5 -1.1
Neuroticism 0.5 1.3 2.8 -1.0 -1.2 0.0 1.7
Chronotype (morning person) 0.3 0.7 2.2 -0.3 1.5 -0.2 -0.5
Hair Pigment 0.0 0.7 1.2 1.1 0.6 -0.6 -0.8
Tanning 0.3 3.8 13.7 -0.2 -0.1 3.7 -1.3
Hand grip strength (left) 0.8 2.2 4.7 1.6 1.1 2.2 -0.6
Number of treatments/medications taken 2.1 3.9 13.0 -1.0 1.1 -3.6 0.6
Average weekly spirits intake 0.5 0.6 1.5 -1.2 0.9 -0.1 -0.4
Sensitivity / hurt feelings 1.1 1.9 4.2 2.0 0.5 1.6 0.9
Frequency of depressed mood in last 2 weeks 1.1 1.6 3.8 -1.5 1.9 -0.0 0.6
Hearing difficulty/problems: Yes 0.7 1.0 3.2 0.8 0.5 1.8 -0.1
Relative age of first facial hair 0.7 1.6 6.1 0.2 0.2 2.5 0.0
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.8 -0.8 0.2 -1.3 -1.1
Ever used hormone-replacement therapy (HRT) 1.4 1.8 4.5 0.9 -0.7 -1.1 2.1
Ever had hysterectomy (womb removed) 0.4 0.5 1.5 -0.2 -0.1 -0.6 -1.2
Systolic blood pressure, automated reading 0.8 2.2 6.2 -0.3 -0.4 -2.5 1.6
Eye problems/disorders: Diabetes related eye disease 2.6 2.9 6.1 -1.9 2.5 -0.8 -1.0
Angina 1.1 1.4 2.8 -0.3 0.1 -1.7 1.6
Medication for hormone replacement therapy 0.5 0.6 1.4 0.2 -0.0 -1.2 1.0
Vitamin and mineral supplements 0.3 0.4 1.2 -0.1 -1.1 0.5 0.5
Supplements: Zinc 0.5 0.6 1.3 -0.8 -1.1 -0.6 0.0
Medication: Co-codamol 0.4 0.5 1.6 -1.3 0.5 -0.2 -0.4
Medication: Metformin 0.2 0.3 0.6 0.3 0.2 -0.8 -0.7
Diabetes (father) 0.4 0.5 1.4 0.2 0.7 -0.1 -1.2
Diabetes (mother) 0.8 1.1 2.8 -0.4 1.7 -0.8 -0.8
Severe depression (siblings) 0.5 0.6 1.1 -0.7 -1.0 -0.4 -0.8
Pack years adult smoking proportion 3.6 5.5 14.8 0.3 3.9 -2.7 -0.2
Impedance of leg (right) 2.1 10.2 34.7 2.1 -1.2 5.9 0.5
Leg fat-free mass (left) 2.0 11.0 36.0 -0.5 2.0 -6.0 -2.0
Trunk fat percentage 1.8 7.4 29.1 0.0 0.7 -5.4 0.4
Hand grip strength (right) 1.2 3.4 5.2 2.1 1.7 2.3 -0.9
Townsend deprivation index at recruitment 0.8 1.1 2.9 -0.7 1.7 -0.6 0.9
Current tobacco smoking 1.1 1.8 3.6 -1.1 1.2 -1.9 -1.0
Average weekly fortified wine intake 1.6 1.8 3.7 1.9 -0.1 -1.9 -0.1
Maternal smoking around birth 0.5 0.7 2.3 -1.5 -0.3 -0.4 0.3
Fed-up feelings 0.5 0.9 2.5 -0.9 0.5 -1.6 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 3.0 4.0 10.3 -1.1 3.2 -1.1 -1.8
Relative age voice broke 1.0 1.6 4.7 1.2 0.2 2.2 -0.6
Taking other prescription medications 1.4 2.2 5.5 1.0 1.4 -2.3 -0.6
Age when periods started (menarche) 1.4 3.5 6.8 0.8 1.8 2.6 -1.7
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 4.1 -2.0 0.2 -0.1 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 5.3 0.8 2.3 1.3 -1.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.6 -0.2 0.3 -0.0 -1.3
Qualifications: CSEs or equivalent 0.7 0.9 1.5 -0.8 -1.2 0.8 1.0
Serious illness, injury or assault to yourself 0.5 0.6 2.0 0.0 0.4 1.4 -0.5
High blood pressure 1.7 4.9 11.2 0.0 2.4 -3.3 1.5
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.4 1.6 -0.8 0.9 0.7
Multivitamins +/- minerals 0.8 1.1 2.3 0.7 1.5 -1.2 0.2
Stomach or abdominal pain in last month 0.4 0.5 1.7 0.2 0.5 -0.3 -1.3
Supplements: Glucosamine 0.8 1.1 2.0 -0.9 -1.4 -1.2 0.2
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 4.9 -0.8 -0.2 2.2 0.7
Medication: Atenolol 0.8 1.0 2.7 0.2 1.0 -1.6 -0.5
Medication: Levothyroxine sodium 0.6 1.0 3.1 0.4 1.8 -0.7 -0.2
Sitting height 0.4 2.7 5.6 0.8 1.3 -2.4 -1.7
Chronic bronchitis/emphysema (father) 0.2 0.3 0.5 -0.7 -0.1 -0.5 0.6
High blood pressure (mother) 0.3 0.4 1.3 -0.5 0.1 -1.1 0.3
Body mass index (BMI) 3.7 16.1 61.4 -1.4 1.1 -7.8 0.2
Impedance of leg (left) 2.0 9.8 35.2 1.4 -1.1 5.9 0.9
Leg predicted mass (left) 2.1 11.3 37.3 -0.4 1.9 -6.1 -2.0
Trunk fat mass 2.3 10.2 39.9 -0.1 1.1 -6.3 -0.1
Waist circumference 2.9 11.1 42.8 -1.2 0.2 -6.5 -0.2
Number of incorrect matches in round 0.7 1.2 3.6 -0.7 -1.9 0.3 0.8
Past tobacco smoking 1.5 2.7 6.0 0.3 2.4 1.9 -1.0
Alcohol usually taken with meals 1.9 3.1 8.4 2.9 -1.9 -0.6 -0.1
Nervous feelings 0.4 0.8 1.6 1.3 0.8 0.4 -0.8
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.7 5.5 0.8 2.3 -1.5 -1.5
Hearing difficulty/problems with background noise 0.3 0.5 1.1 0.9 0.0 -1.1 -0.1
Hair/balding pattern: Pattern 2 0.6 0.7 2.4 0.3 -0.1 -1.5 0.6
Had menopause 0.2 0.2 0.5 0.2 0.2 0.7 -0.5
Had other major operations 0.5 0.6 1.7 -0.3 -0.3 -1.3 0.8
Forced vital capacity (FVC) 0.6 2.2 7.1 0.5 0.7 2.7 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 2.4 1.5 0.8 0.3 -1.5
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.5 -0.7 1.6 -0.0 -0.0
Qualifications: None of the above 2.1 4.5 14.5 -0.8 1.3 -3.8 -1.0
Financial difficulties in last 2 years 2.0 2.7 6.2 -1.8 0.1 -2.5 -1.1
Mouth/teeth dental problems 0.7 1.1 2.9 0.9 -0.7 1.7 -0.6
Heart attack 1.6 2.0 4.3 0.1 0.1 -2.1 2.0
Allergy 0.5 1.2 1.9 -1.4 1.1 0.4 -1.2
Pain all over the body in last month 1.4 1.5 2.1 -1.2 1.4 -1.4 -0.7
Diabetes (self-reported) 0.3 0.5 0.7 -0.1 0.8 -0.8 0.8
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.8 -0.0 -0.9 -0.1 -0.1
Medication: Ramipril 3.0 3.8 8.9 0.7 -2.4 -3.0 -0.1
Medication: Simvastatin 1.6 2.3 7.1 -0.4 1.3 -2.7 0.6
Fluid intelligence score 0.9 2.0 5.9 -2.4 0.7 0.9 0.8
Illnesses of siblings 1.3 1.8 6.7 -0.3 -0.5 2.6 0.6
Neuroticism score 0.4 0.7 1.2 0.8 1.1 0.2 -1.1
Weight 2.6 12.9 48.4 -0.5 1.4 -7.0 -1.0
Impedance of arm (right) 2.2 10.5 38.4 0.7 -1.2 6.2 1.3
Arm fat percentage (right) 2.5 10.0 37.7 -1.1 0.5 -6.1 1.0
Trunk fat-free mass 1.2 6.8 18.8 -0.4 2.0 -4.3 -2.1
Hip circumference 2.7 12.1 47.0 -0.7 0.6 -6.9 -0.8
Time employed in main current job 1.3 1.5 2.7 1.6 0.7 1.7 0.4
Alcohol intake versus 10 years previously 0.9 1.4 4.5 0.8 0.1 -2.1 -0.8
Father’s age at death 1.2 1.7 5.7 -0.7 -2.4 -0.3 0.6
Worrier / anxious feelings 1.7 3.3 6.6 1.7 0.2 2.6 -1.9
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 4.6 1.1 0.4 -2.1 -0.5
Falls in the last year 0.3 0.4 1.0 -0.6 -0.5 0.2 1.0
Hair/balding pattern: Pattern 3 0.7 1.0 1.6 0.2 1.0 1.2 -1.3
Number of live births 0.6 0.8 1.7 0.8 0.3 0.9 1.3
Forced expiratory volume in 1-second (FEV1) 0.9 3.0 10.2 0.4 1.1 3.2 -0.5
Pulse rate 0.3 0.6 1.2 -1.0 -0.1 0.1 -1.1
Happiness 0.5 0.6 1.7 -0.7 -1.3 0.4 0.3
Noisy workplace 0.6 0.7 1.2 -0.5 -0.6 -1.0 -1.1
Qualifications: A levels/AS levels or equivalent 0.7 1.6 3.7 -0.4 -1.9 1.5 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.7 0.3 0.1 -0.4 -1.3
Mouth/teeth dental problems: Dentures 2.0 3.4 8.2 -1.4 1.8 -2.9 0.3
Asthma 1.3 2.6 5.5 1.9 -1.0 -2.3 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.1 3.0 0.0 -0.6 -1.7 1.0
Medication: Cholesterol lowering 0.9 1.4 3.0 -0.5 -0.1 -1.5 1.7
Depression (self-reported) 1.2 1.4 2.6 -0.3 1.6 -1.4 -1.0
Medication: Lansoprazole 0.9 1.0 2.8 -0.4 0.7 -1.7 0.9
Prospective memory result 0.4 0.5 1.6 1.3 0.4 -0.6 -0.0
Lung cancer (father) 0.7 0.9 2.3 1.5 -0.1 -0.4 1.0
Illnesses of mother 1.3 1.6 5.1 1.1 -0.3 2.3 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.4 14.4 -0.1 1.8 3.8 0.0
Pulse wave Arterial Stiffness index 0.7 0.8 2.9 0.3 -0.4 -0.1 1.7
Impedance of arm (left) 1.7 8.2 29.3 1.6 -0.8 5.4 0.6
Arm fat mass (right) 3.0 12.7 48.4 -1.1 1.1 -7.0 0.3
Trunk predicted mass 1.2 7.1 19.8 -0.4 2.0 -4.4 -2.1
Standing height 0.3 3.0 6.4 1.6 1.3 1.2 -2.5
Length of working week for main job 0.7 0.8 2.3 -0.5 1.5 -0.2 0.9
Exposure to tobacco smoke at home 1.6 1.8 3.8 -2.0 1.2 -1.2 0.6
Breastfed as a baby 1.1 1.4 3.4 1.8 1.3 0.6 0.2
Tense / ‘highly strung’ 2.0 3.3 9.2 -0.4 3.0 1.0 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 3.7 5.6 13.5 -1.4 1.6 -3.7 -2.1
Hair/balding pattern: Pattern 4 0.3 0.9 1.8 -1.3 0.0 0.9 0.9
Birth weight of first child 0.1 0.2 0.4 -0.6 -0.3 -0.5 -0.3
Peak expiratory flow (PEF) 0.4 1.0 3.6 0.2 0.2 1.9 -0.5
Pulse wave reflection index 0.8 1.0 3.4 0.8 -0.2 -0.2 1.8
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.1 -0.3 -0.2 -1.0 -0.2
Loud music exposure frequency 0.2 0.2 0.6 -0.8 0.3 -0.2 -0.3
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 3.0 -0.3 -0.9 1.7 -0.6
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.1 0.3 -0.3 0.2 0.3
Blood clot in the leg (DVT) 1.2 1.5 4.0 -1.1 0.1 0.9 2.0
Medication: Paracetamol 1.1 1.8 5.8 0.4 -0.1 -1.1 2.4
Headache pain in last month 0.9 1.6 2.8 -1.7 1.6 1.0 0.2
Medication for cholesterol, blood pressure or diabetes 1.9 3.2 8.1 0.3 0.0 2.9 -2.1
Glaucoma (self-reported) 0.6 0.7 1.8 -1.4 0.8 -0.2 0.4
Gout (self-reported) 0.4 0.5 1.5 1.2 0.2 0.6 0.3
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.1 -0.7 1.5 -0.8 -0.2
Medication: Amlodipine 0.6 0.9 1.9 -1.2 -0.3 -0.4 1.4
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.8 0.8 0.4 -0.9 -0.1
Birth weight 1.1 2.5 7.6 -2.8 -1.0 1.1 0.0
Chronic bronchitis/emphysema (mother) 1.0 1.1 3.3 1.8 -0.0 -0.3 1.0
High blood pressure (siblings) 1.4 2.0 7.6 -0.2 -0.7 -2.8 0.1
Forced vital capacity (FVC), Best measure 0.8 3.0 11.4 0.0 0.7 3.4 -0.4
Body fat percentage 2.2 8.9 35.2 -0.3 0.4 -5.9 0.6
Leg fat percentage (right) 2.7 9.9 38.5 0.2 0.2 -6.2 1.0
Arm fat-free mass (right) 1.8 9.7 30.7 0.1 1.9 -5.5 -2.1
Exposure to tobacco smoke outside home 1.9 2.6 7.4 -1.5 -0.8 -2.7 -0.3
Comparative body size at age 10 1.8 5.0 13.0 -2.4 1.1 -3.6 0.2
Number of full brothers 2.0 2.5 9.2 0.5 0.6 -3.0 -0.2
Worry too long after embarrassment 0.9 1.5 2.8 0.2 1.2 1.7 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 3.4 4.4 11.3 -0.7 1.9 -3.4 -1.4
Wheeze or whistling in the chest in last year 3.0 5.4 20.7 0.5 0.1 -4.5 -0.8
Number of children fathered 0.4 0.5 1.2 -1.1 0.0 -0.9 0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 3.1 1.0 0.1 0.9 1.8
Age at first live birth 1.6 2.8 10.0 -0.9 0.7 3.2 -0.1
Pulse wave peak to peak time 0.8 1.0 3.5 -0.2 0.5 0.4 -1.9
Health satisfaction 0.6 0.8 2.3 -1.5 -0.2 -0.5 0.6
Shortness of breath walking on level ground 0.6 0.7 1.5 -1.2 0.1 -1.1 -0.3
Qualifications: College or University degree 0.9 3.0 6.7 2.6 -1.6 1.7 0.1
Eye problems/disorders: None of the above 0.7 0.8 1.4 1.1 -0.2 -0.6 1.2
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.0 0.2 0.1 -1.0 0.7
Emphysema/chronic bronchitis 1.9 2.2 4.1 2.0 -0.5 -1.9 -0.8
Medication for pain relief, constipation, heartburn 2.3 4.1 9.7 0.8 1.0 3.1 -2.2
Neck or shoulder pain in last month 0.6 0.9 2.2 -1.0 -0.1 -1.5 0.4
Medication: Blood pressure 1.4 2.6 8.7 -0.1 0.7 -2.9 1.1
Angina (self-reported) 1.2 1.5 3.9 -0.2 0.1 -2.0 1.5
Migraine (self-reported) 1.2 1.4 5.5 -0.5 2.3 -0.2 0.1
Medication: Ibuprofen 0.5 0.7 1.3 -0.4 -0.6 -1.2 0.9
Medication: Allopurinol 0.1 0.2 0.6 0.3 -0.3 0.0 -0.8
Medication: Omeprazole 0.6 0.7 2.5 -0.1 -0.3 -0.5 -1.6
Medication: Seretide 50 evohaler 0.6 0.7 1.6 0.8 0.7 -1.3 -0.4
Mean time to correctly identify matches 0.8 1.6 3.2 1.3 0.6 -1.8 -1.0
Heart disease (mother) 0.8 1.0 2.6 -0.6 -0.9 -1.6 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 3.3 0.8 -0.1 -1.5 -1.8
Whole body fat mass 2.8 11.9 46.4 -0.4 1.0 -6.8 -0.1
Leg fat mass (right) 3.3 13.3 52.6 -0.3 0.7 -7.2 0.1
Arm predicted mass (right) 1.9 9.7 30.6 -0.1 2.0 -5.5 -2.1
Pulse rate, automated reading 0.6 1.8 2.8 -1.1 1.2 1.4 -1.7
Alcohol intake frequency. 1.0 2.4 6.9 0.9 1.0 -2.6 -0.9
Comparative height size at age 10 0.3 1.7 4.8 0.9 -0.6 -2.2 -0.8
Number of full sisters 1.9 2.3 5.0 -0.3 2.2 -2.0 -0.1
Suffer from ‘nerves’ 0.5 0.8 2.8 0.2 0.2 1.7 0.4
Overall health rating 1.0 2.1 6.7 -0.9 0.8 -2.6 0.4
Chest pain or discomfort 1.0 1.4 3.0 -0.8 1.1 -1.7 -0.8
Had major operations 0.6 0.7 1.6 1.0 0.5 -0.3 -1.3
Age at last live birth 0.9 1.3 4.6 -0.5 0.4 2.1 -0.5
Family relationship satisfaction 0.3 0.4 1.2 -0.1 0.2 1.1 -0.6
Leg pain on walking 1.7 2.1 4.9 -2.2 -0.3 -1.4 -1.2
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.5 3.9 -0.5 -2.0 -1.9 1.4
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.1 -1.4 -1.2 -0.3 -0.1
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 2.9 0.2 0.5 0.8 1.7
Medication: Aspirin 1.2 1.5 3.5 -1.1 0.1 -1.9 1.2
Supplements: Vitamin C 1.3 1.5 2.4 0.8 0.9 1.5 -1.6
Knee pain experienced in last month 0.4 0.6 1.3 0.7 -1.1 -0.5 0.4
Hypertension (Self-reported) 1.7 4.8 10.5 -0.4 2.4 -3.2 1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.7 0.5 0.6 0.1 -0.9
Illnesses of father: Heart disease 0.6 0.9 1.3 -0.8 0.9 -0.8 1.1
Illnesses of siblings: Diabetes 0.3 0.3 1.1 -1.0 -0.2 -0.4 -0.1
Smoking status: Previous 1.8 2.8 6.7 -0.8 -2.6 -1.7 1.0
Forced expiratory volume in 1-second (FEV1), predicted 2.4 5.0 8.7 -0.7 2.7 3.0 -1.9
Whole body fat-free mass 1.5 8.9 27.0 -0.4 2.0 -5.2 -2.1
Leg fat-free mass (right) 1.9 10.2 34.0 -0.9 1.8 -5.8 -1.6
Arm fat percentage (left) 2.6 10.7 41.6 -0.6 0.6 -6.4 0.7
Average weekly red wine intake 0.4 0.6 1.4 1.2 -0.9 -0.1 0.6
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.6 -0.4 0.7 0.2 1.6
Mood swings 0.5 1.0 2.3 -0.4 1.5 -1.2 0.1
Loneliness, isolation 0.3 0.5 0.9 0.9 0.2 -0.6 -0.8
Long-standing illness, disability or infirmity 2.4 3.7 14.7 0.0 0.0 -3.8 -0.2
Ever had bowel cancer screening 1.4 1.6 2.6 1.4 1.2 -1.6 -0.7
Diabetes diagnosed by doctor 0.4 0.6 0.9 0.5 0.9 -0.8 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.2 0.6 -0.8 0.1 0.1 0.1
Friendships satisfaction 0.3 0.4 1.5 0.1 1.2 0.0 -0.4
Qualifications: nursing, teaching 1.8 2.8 9.9 0.4 -0.1 3.1 1.1
Commuting to job workplace: Walk 0.8 0.9 1.5 1.2 -0.0 0.9 1.1
Eye problems/disorders: Cataract 0.6 0.7 1.7 -0.5 -1.3 -0.9 0.2
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 2.3 -0.7 -1.5 0.2 0.2
Medication for cholesterol 2.0 3.1 12.0 0.3 -0.4 3.5 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.8 3.3 9.1 -0.6 -1.6 -3.0 1.1
Back pain experienced in last month 0.4 0.5 2.0 -0.3 1.4 -0.2 -0.1
Mineral and other dietary supplements 0.4 0.5 1.0 0.7 1.0 0.6 0.2
Breast cancer (self-reported) 0.7 0.8 2.2 -0.9 1.5 -0.2 -0.2
Asthma (self-reported) 1.1 2.1 4.2 1.8 -0.8 -2.0 0.5
Osteoporosis (self-reported) 0.4 0.5 1.1 0.3 1.0 0.9 -0.0
Osteoarthritis (self-reported) 0.5 0.6 1.9 -0.2 -1.4 -0.8 -0.1
Medication: Aspirin 1.1 1.5 3.0 -0.8 -0.1 -1.4 1.7
Medication: Gliclazide 0.8 0.9 2.0 1.4 0.7 0.2 -1.0
Illnesses of father: None of the above (group 1) 1.2 1.5 3.0 1.7 -1.2 0.9 -0.8
Smoking status: Current 1.0 1.5 2.9 -0.9 1.2 -1.7 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.2 7.4 0.5 1.1 2.7 -0.1
Whole body water mass 1.5 8.7 26.1 -0.6 2.1 -5.1 -2.0
Leg predicted mass (right) 1.9 10.6 34.8 -0.9 1.9 -5.9 -1.7
Arm fat mass (left) 3.1 13.0 50.9 -0.6 1.0 -7.1 -0.0
Number of self-reported non-cancer illnesses 0.5 0.9 3.2 -0.0 0.4 -1.8 0.4
Average weekly champagne plus white wine intake 0.4 0.6 1.3 -0.2 -0.7 -0.8 1.1
Miserableness 0.1 0.2 0.7 0.9 0.1 0.3 0.3
Guilty feelings 0.8 1.3 2.9 1.7 0.9 -0.3 -1.2
Wears glasses or contact lenses 2.1 2.4 6.5 -1.5 2.6 -0.9 0.1
Ever taken oral contraceptive pill 0.9 1.0 2.7 -1.6 0.5 -0.9 0.7
Hearing aid user 0.9 1.0 2.9 1.7 1.0 0.2 0.0
Mother’s age at death 1.7 2.2 7.7 -0.6 -0.6 2.8 0.4
Financial situation satisfaction 2.1 2.6 4.3 -1.6 -1.9 -2.1 0.2
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.2 1.5 -0.3 -0.7 0.2
Commuting to job workplace: Public transport 0.3 0.4 1.0 1.0 -0.4 -0.3 -0.4
Eye problems/disorders: Glaucoma 0.6 0.7 1.2 -0.7 1.0 1.1 -0.0
Medication: Blood pressure 2.5 4.8 17.7 -0.7 1.0 -4.2 -0.2
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.8 -0.3 -0.9 -0.9 0.1
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.2 0.4 -0.4 -0.2 -0.3
High cholesterol (Self-reported) 1.5 2.6 8.4 -1.1 0.8 -2.9 0.2
Medication: Bendroflumethiazide 1.3 2.0 5.4 0.0 1.3 -2.3 -1.0
Medication: Paracetamol 0.8 1.2 3.5 0.9 0.4 -0.6 1.9
Medication: Lisinopril 0.8 1.1 2.1 0.5 0.9 -1.0 1.5
Medication: Atorvastatin 0.7 0.8 2.7 0.4 0.4 -0.5 1.6
Illnesses of father: High blood pressure 0.6 0.7 1.9 -0.8 -0.2 -1.4 0.4
Alcohol drinker status: Never 1.3 1.6 5.8 0.8 0.1 -2.4 0.2
Ever smoked 2.2 3.9 7.6 -0.7 -2.8 -2.8 0.1
Basal metabolic rate 1.8 10.1 32.5 -0.5 1.9 -5.7 -2.0
Leg fat percentage (left) 2.9 10.5 40.5 -0.2 0.3 -6.4 1.2
Arm fat-free mass (left) 1.7 8.9 29.6 -0.6 1.6 -5.4 -1.7
Number of operations (self-reported) 0.6 0.9 3.2 -0.3 0.6 -0.1 -1.8
Average weekly beer plus cider intake 1.1 1.6 3.5 -1.7 -1.9 0.2 -0.0
Irritability 1.1 1.8 3.7 0.8 1.5 -1.9 -0.8
Risk taking 1.1 1.6 3.8 -0.5 -0.2 -2.0 -1.5
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.7 0.1 -0.3 0.5 1.6
Fractured/broken bones in last 5 years 1.2 1.6 5.1 0.6 -2.3 0.9 0.4
Age started oral contraceptive pill 0.5 0.6 1.8 1.3 0.4 -0.2 -0.6
Diastolic blood pressure, automated reading 0.4 1.1 2.9 -1.7 0.2 -0.8 1.0
Ever depressed for a whole week 0.2 0.3 0.7 -0.1 0.8 -0.5 -0.4
Unable to work because of sickness or disability 0.5 0.7 2.0 1.4 0.6 0.6 0.1
Commuting to job workplace: Cycle 2.3 2.8 7.2 2.7 0.9 1.4 1.2
Myopia 0.6 0.9 2.6 -0.0 -1.6 -0.9 -0.5
Vascular/heart problems diagnosed by doctor 2.4 6.8 17.5 -0.0 -2.3 4.2 -2.1
Cholesterol lowering medication 1.1 1.5 4.9 0.1 1.1 -2.2 0.2
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.5 -0.3 -0.4 -1.2 -0.8
Pain experienced in last month 0.3 0.4 1.1 0.4 -0.5 1.1 -0.4
Supplements: Calcium 0.7 0.8 2.9 -1.7 -0.1 0.0 0.5
Basal cell carcinoma (self-reported) 0.3 0.3 1.0 1.0 0.2 0.6 0.1
Heart attack/myocardial infarction (self-reported) 1.8 2.3 4.6 0.2 0.2 -2.1 2.1
Deep venous thrombosis (DVT) (self-reported) 1.0 1.2 4.2 -0.8 0.1 0.2 2.0
Heart disease (siblings) 1.1 1.3 3.1 0.5 0.3 -1.4 -1.8
Alcohol drinker status: Previous 0.1 0.1 0.2 -0.3 -0.2 -0.4 -0.4
Pack years of smoking 3.2 4.7 13.9 0.6 3.7 -2.2 0.1
Impedance of whole body 2.2 11.6 41.4 1.9 -1.0 6.4 0.7
Leg fat mass (left) 3.5 13.9 54.7 -0.4 0.9 -7.4 0.2
Arm predicted mass (left) 1.7 8.9 28.6 -0.7 1.8 -5.3 -1.8