Hub : Genes

RP1-65P5.3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0892	0.0384	6.5e-03	0.055	NA	0.047	NA	0.048	3.6e-05	NA	1.4e-04	NA	1.2e-04
2	GTEx	Cells Transformed fibroblasts	0.1850	0.0450	8.5e-08	0.077	NA	0.121	NA	0.106	2.0e-06	NA	2.5e-09	NA	2.5e-08
3	GTEx	Muscle Skeletal	0.1512	0.0374	4.0e-07	0.061	NA	0.067	NA	0.098	1.3e-06	NA	3.9e-07	NA	7.0e-10
4	GTEx	Thyroid	0.0850	0.0320	1.9e-03	0.041	NA	0.012	NA	0.033	3.9e-04	NA	3.5e-02	NA	1.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.5	2.3	3.3	-0.5	-1.8	-1.8	-1.6
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	-0.4	-0.3	-0.8	-0.4
Depressed Affect (Nagel 2018)	1.7	3.5	7.7	-2.8	-1.3	-1.6	-1.4
Depression (Nagel 2018)	1.1	1.7	3.7	-1.9	-0.9	-1.0	-1.1
Intelligence (Savage-Jansen 2018)	0.5	1.6	4.2	2.0	0.7	1.2	0.7
Neuroticism (Nagel 2018)	1.6	3.8	9.6	-3.1	-0.9	-1.6	-1.5
Schizophrenia (2018)	0.2	0.5	1.1	-0.0	1.0	0.4	0.8
Schizophrenia vs Biploar Disorder	1.8	2.4	3.2	1.1	1.8	1.7	1.5
Worry (Nagel 2018)	0.3	0.7	2.4	-1.6	0.5	-0.2	-0.4
Alzheimer’s Disease (in mother)	2.8	3.3	4.9	-1.2	-1.8	-1.9	-2.2
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.5	0.1	0.0	0.5
Alzheimer’s Disease (including proxy)	1.7	2.5	2.8	-1.7	-1.4	-1.7	-1.6
Crohns Disease (2017)	0.7	1.5	2.1	-1.4	-1.1	-1.0	-1.4
Irritable Bowel Disease (IBD)	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.2
Ulcerative Colitis (UC)	0.2	0.5	0.7	0.8	0.4	0.7	0.7
Major Depression (MDD)	0.8	1.0	2.7	-1.6	-0.5	-0.8	-0.5
Reaction Time	0.4	0.8	2.2	0.9	1.5	0.6	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.9	1.4	0.3	0.2	0.1
Breast Cancer	0.1	0.1	0.5	-0.7	0.2	-0.3	-0.0
Ovarian Cancer	2.0	2.6	3.9	0.8	2.0	1.6	1.8
Prostate Cancer	0.1	0.1	0.2	-0.4	-0.2	-0.0	0.4
Age at First Birth	0.2	0.4	0.7	0.4	0.3	0.8	0.7
Bipolar Disorder (2011)	0.8	0.8	1.2	0.8	-1.1	-0.8	-0.8
Body Mass Index (BMI) (2010)	0.2	0.3	1.1	-0.1	-1.1	-0.3	-0.1
Coronary Artery Disease (CAD)	1.5	1.8	4.1	0.1	-2.0	-1.3	-1.2
Crohns Disease (2012)	0.9	1.5	2.1	-1.1	-1.3	-1.0	-1.4
Mean Putamen Volume	4.3	4.9	6.8	2.0	2.6	1.9	2.3
Fasting Glucose	1.7	2.0	3.5	-0.7	-1.9	-1.5	-1.3
HbA1C	0.1	0.1	0.2	0.5	-0.1	0.1	0.3
HDL Cholesterol	0.1	0.1	0.4	0.6	0.2	0.0	0.1
LDL Cholesterol	6.7	10.6	13.6	-2.5	-3.4	-3.7	-3.3
Lupus	0.1	0.1	0.3	-0.5	0.0	0.1	0.5
Neuroticism (2016)	0.6	0.9	3.1	-1.8	-0.1	-0.7	-0.2
Primary Biliary Cirrhosis	1.5	2.1	2.9	-1.1	-1.7	-1.6	-1.3
Rheumatoid Arthritis	3.7	5.2	6.4	-1.5	-2.4	-2.5	-2.5
Schizophrenia (2014)	0.0	0.1	0.2	-0.4	0.3	-0.3	0.1
Triglycerides	1.1	1.8	2.8	-1.7	-1.2	-1.3	-1.2
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.5	0.7	-0.5	-0.3	-0.4
Ulcerative Colitis	0.5	0.8	1.3	0.6	1.1	0.9	0.9
Blood Eosinophil Count	0.0	0.1	0.1	-0.3	0.1	0.3	-0.3
Blood Platelet Count	0.1	0.7	1.2	0.1	1.1	0.7	1.1
Blood Red Count	2.3	22.2	32.0	-4.4	-5.7	-4.4	-4.3
Blood White Count	1.1	8.2	10.0	-3.2	-3.1	-2.6	-2.5
Heel T-Score	1.5	12.0	14.5	-3.4	-3.0	-3.5	-3.8
BMI	2.1	12.4	14.7	-3.8	-3.6	-3.4	-3.3
Height	1.0	19.9	23.1	4.7	4.8	4.2	4.1
Waist Hip Ratio (WHR)	0.4	1.7	1.9	-1.3	-1.1	-1.4	-1.4
Systolic Blood Pressure	0.3	1.5	2.6	-1.2	-0.7	-1.1	-1.6
Smoking Status	1.7	4.1	6.2	-2.5	-1.9	-2.1	-1.6
Allergy or Eczema	0.3	0.7	1.0	1.0	0.7	0.7	0.8
Cardiovascular Disease	1.9	6.1	8.8	-3.0	-1.9	-2.3	-2.5
Hypothyroidism (self reported)	0.1	0.2	0.4	0.3	-0.5	-0.6	-0.2
Respiratory disease	0.2	0.5	0.7	0.7	0.9	0.8	0.5
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.2	-0.4	-1.5	-1.0	-1.2
Lung FEV1/FVC ratio	0.2	1.0	2.3	-1.5	-0.2	-1.2	-0.5
Lung FVC	0.1	0.4	0.7	-0.4	-0.8	-0.4	-0.8
Neuroticism	0.4	0.9	3.6	-1.9	0.3	-0.3	0.0
Chronotype (morning person)	0.2	0.6	1.2	-0.6	1.1	0.6	0.6
Hair Pigment	0.1	2.5	3.7	-1.9	-1.7	-1.3	-1.4
Tanning	0.4	5.0	6.7	-2.0	-2.2	-2.6	-2.0
Hand grip strength (left)	0.1	0.4	1.2	-0.1	-1.1	-0.2	-0.4
Number of treatments/medications taken	1.5	2.7	4.9	-1.4	-1.3	-1.5	-2.2
Average weekly spirits intake	0.9	1.1	2.4	-1.5	-1.0	-0.7	-0.7
Sensitivity / hurt feelings	0.3	0.5	1.7	-1.3	-0.4	-0.2	-0.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.0	-1.4	-0.2	-0.6	-0.3
Hearing difficulty/problems: Yes	1.0	1.5	2.9	-0.9	-1.2	-0.8	-1.7
Relative age of first facial hair	0.5	1.0	1.8	0.2	-1.0	-1.1	-1.3
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.0	-0.9	-1.1	-1.2	-1.7
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.2	-0.7	-1.1	-1.2	-1.5
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	-0.5	-0.5	-1.0	-0.4
Systolic blood pressure, automated reading	0.4	1.0	2.0	-1.4	-0.4	-0.7	-1.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.7	1.3	-0.2	0.2	-0.0
Angina	0.2	0.2	0.5	-0.2	0.3	0.7	0.4
Medication for hormone replacement therapy	0.6	0.7	1.5	-1.2	-0.4	-0.8	-0.7
Vitamin and mineral supplements	0.2	0.3	0.4	-0.7	-0.2	-0.7	-0.5
Supplements: Zinc	0.4	0.4	1.2	1.1	0.2	0.1	0.5
Medication: Co-codamol	0.4	0.5	1.2	1.1	0.5	0.6	0.3
Medication: Metformin	0.4	0.6	1.0	1.0	-0.9	-0.3	-0.4
Diabetes (father)	0.4	0.5	0.9	1.0	0.3	0.7	0.7
Diabetes (mother)	0.2	0.2	0.5	-0.3	0.7	-0.0	0.6
Severe depression (siblings)	3.3	3.7	5.2	-2.1	-2.3	-1.5	-1.7
Pack years adult smoking proportion	0.1	0.1	0.4	-0.6	0.1	-0.0	-0.1
Impedance of leg (right)	0.1	0.7	2.4	-0.5	1.5	0.1	0.5
Leg fat-free mass (left)	0.2	1.1	2.3	1.5	-0.1	1.1	0.9
Trunk fat percentage	0.3	1.3	1.5	-1.2	-1.1	-1.2	-1.0
Hand grip strength (right)	0.2	0.6	1.2	0.5	-1.1	-0.4	-0.8
Townsend deprivation index at recruitment	3.9	5.5	7.6	-1.8	-2.8	-2.3	-2.4
Current tobacco smoking	0.9	1.5	5.1	-2.2	-0.6	-0.8	-0.3
Average weekly fortified wine intake	0.6	0.7	1.4	0.2	0.7	1.2	1.0
Maternal smoking around birth	12.1	17.4	19.6	-3.8	-4.1	-4.4	-4.4
Fed-up feelings	1.8	3.4	5.0	-2.2	-1.6	-2.0	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	5.9	7.9	12.7	-3.6	-2.3	-2.8	-2.4
Relative age voice broke	0.1	0.2	0.3	0.6	-0.3	-0.4	-0.6
Taking other prescription medications	0.5	0.7	1.2	-0.6	-0.8	-0.7	-1.1
Age when periods started (menarche)	0.2	0.4	0.5	0.6	0.7	0.7	0.5
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.3	-0.9	-0.8	-1.5	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	1.6	-0.9	-1.3	-1.2	-0.9
Tinnitus: Yes, but not now, but have in the past	5.0	5.3	6.6	-2.0	-2.6	-2.3	-2.3
Qualifications: CSEs or equivalent	2.6	3.4	6.6	-0.8	-2.6	-1.9	-1.6
Serious illness, injury or assault to yourself	3.5	4.2	5.2	-1.9	-2.1	-1.9	-2.3
High blood pressure	0.8	2.3	3.6	-1.9	-0.8	-1.2	-1.9
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.4	0.7	-0.2	-0.2	-0.1
Multivitamins +/- minerals	0.3	0.4	0.7	-0.3	-0.9	-0.4	-0.7
Stomach or abdominal pain in last month	0.2	0.3	1.0	-0.3	-0.1	-1.0	-0.2
Supplements: Glucosamine	0.2	0.2	0.4	0.7	0.4	0.5	0.1
Diverticular disease/diverticulitis (self-reported)	3.3	4.0	5.2	-1.7	-2.3	-1.9	-2.0
Medication: Atenolol	0.2	0.2	0.6	-0.8	0.2	-0.6	0.1
Medication: Levothyroxine sodium	0.1	0.1	0.4	-0.1	-0.2	-0.4	-0.6
Sitting height	2.5	17.5	21.8	4.7	3.9	4.1	4.0
Chronic bronchitis/emphysema (father)	1.2	1.4	2.2	-0.2	-1.5	-1.1	-1.5
High blood pressure (mother)	0.8	1.2	2.0	0.3	1.4	1.1	1.2
Body mass index (BMI)	2.1	9.1	12.9	-2.5	-3.6	-3.0	-2.9
Impedance of leg (left)	0.1	0.5	1.8	-0.4	1.3	-0.1	0.4
Leg predicted mass (left)	0.2	1.1	2.4	1.5	-0.1	1.1	0.9
Trunk fat mass	0.1	0.6	1.1	-0.7	-1.0	-0.8	-0.6
Waist circumference	0.9	3.3	5.0	-1.3	-2.2	-1.8	-1.8
Number of incorrect matches in round	0.3	0.4	1.0	-0.1	-1.0	-0.6	-0.6
Past tobacco smoking	0.9	1.7	2.1	1.1	1.4	1.4	1.2
Alcohol usually taken with meals	0.7	1.1	1.5	1.1	1.0	0.7	1.2
Nervous feelings	0.2	0.4	1.3	-1.1	0.2	-0.4	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	1.7	-0.8	-1.3	-1.3	-1.3
Hearing difficulty/problems with background noise	0.1	0.2	0.5	0.7	-0.3	0.2	-0.1
Hair/balding pattern: Pattern 2	0.7	0.9	2.4	-0.2	1.6	0.2	1.1
Had menopause	0.5	0.6	0.9	0.5	0.9	0.9	0.8
Had other major operations	1.2	1.5	2.0	-0.6	-1.4	-1.3	-1.4
Forced vital capacity (FVC)	0.5	2.0	2.4	1.6	1.1	1.6	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	0.7	-0.7	-0.9	-0.8	-0.7
Ever unenthusiastic/disinterested for a whole week	3.7	4.5	6.9	-2.0	-1.6	-2.2	-2.6
Qualifications: None of the above	1.5	3.2	4.4	-2.1	-1.7	-1.7	-1.7
Financial difficulties in last 2 years	4.3	5.8	7.0	-2.2	-2.6	-2.4	-2.3
Mouth/teeth dental problems	6.1	9.4	12.0	2.9	2.9	3.5	3.0
Heart attack	0.6	0.7	2.0	-1.4	-0.5	-0.5	-0.6
Allergy	0.0	0.1	0.2	-0.4	0.2	0.2	0.4
Pain all over the body in last month	0.1	0.1	0.3	0.5	0.1	-0.2	-0.4
Diabetes (self-reported)	0.2	0.4	0.6	0.1	-0.6	-0.8	-0.7
Hayfever/allergic rhinitis (self-reported)	2.2	3.0	4.2	1.0	1.7	2.0	2.0
Medication: Ramipril	0.2	0.2	0.6	-0.8	-0.0	0.4	0.3
Medication: Simvastatin	0.1	0.1	0.4	-0.1	0.7	0.1	0.0
Fluid intelligence score	0.2	0.5	1.3	1.1	0.4	0.5	0.4
Illnesses of siblings	0.9	1.2	2.1	-0.1	-1.5	-1.3	-1.0
Neuroticism score	0.4	0.8	2.8	-1.7	0.0	-0.5	-0.2
Weight	0.2	0.9	2.3	-0.2	-1.5	-0.8	-0.8
Impedance of arm (right)	1.5	6.9	14.8	1.1	3.9	2.5	2.3
Arm fat percentage (right)	0.5	1.8	2.5	-1.6	-1.3	-1.2	-1.3
Trunk fat-free mass	0.2	1.4	2.8	1.7	0.0	1.2	1.1
Hip circumference	0.1	0.3	0.8	-0.2	-0.9	-0.5	-0.5
Time employed in main current job	1.3	1.6	2.4	-0.6	-1.4	-1.3	-1.5
Alcohol intake versus 10 years previously	1.0	1.5	2.4	-0.8	-0.9	-1.5	-1.5
Father’s age at death	1.8	2.4	2.8	1.5	1.6	1.5	1.7
Worrier / anxious feelings	0.5	0.9	2.4	0.3	1.6	0.4	1.0
Frequency of tiredness / lethargy in last 2 weeks	3.1	5.1	5.9	-1.9	-2.3	-2.4	-2.3
Falls in the last year	2.0	2.6	3.8	-2.0	-1.1	-1.6	-1.7
Hair/balding pattern: Pattern 3	0.3	0.5	1.0	-0.4	-1.0	-0.5	-0.6
Number of live births	0.1	0.1	0.2	-0.2	-0.4	0.1	-0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.6	0.8	0.6	0.7	0.8
Pulse rate	9.5	16.0	22.3	-3.9	-4.7	-3.4	-3.8
Happiness	2.0	2.4	6.5	-2.5	-1.1	-1.1	-0.8
Noisy workplace	0.1	0.1	0.3	-0.5	-0.1	0.4	0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	0.3	0.5	0.5	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	-0.1	0.2	-0.0	0.3
Mouth/teeth dental problems: Dentures	5.5	9.3	10.7	-3.3	-2.7	-3.0	-3.2
Asthma	0.0	0.1	0.2	-0.1	-0.0	-0.0	-0.5
Medication: Ibuprofen (e.g. Nurofen)	3.7	4.8	5.7	-2.3	-2.2	-1.9	-2.4
Medication: Cholesterol lowering	0.6	1.0	1.8	-0.5	-1.0	-1.0	-1.3
Depression (self-reported)	2.0	2.4	4.0	-1.5	-1.2	-1.3	-2.0
Medication: Lansoprazole	1.4	1.6	2.2	-1.4	-1.2	-1.5	-1.1
Prospective memory result	0.2	0.3	0.5	0.7	0.5	0.4	0.4
Lung cancer (father)	4.5	5.2	7.1	-1.9	-2.2	-2.3	-2.7
Illnesses of mother	0.4	0.5	1.0	0.1	-1.0	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.0	0.9	0.8	0.9	1.0
Pulse wave Arterial Stiffness index	1.3	1.6	2.2	-1.4	-0.8	-1.3	-1.5
Impedance of arm (left)	1.3	6.0	13.7	1.2	3.7	2.2	2.0
Arm fat mass (right)	0.7	2.8	4.4	-1.4	-2.1	-1.5	-1.6
Trunk predicted mass	0.2	1.3	2.7	1.6	0.0	1.2	1.1
Standing height	2.1	20.8	23.8	4.9	4.4	4.6	4.4
Length of working week for main job	0.5	0.5	0.7	-0.9	-0.8	-0.6	-0.6
Exposure to tobacco smoke at home	2.8	3.2	3.6	-1.9	-1.6	-1.7	-1.9
Breastfed as a baby	1.0	1.3	2.6	1.3	1.6	0.8	0.5
Tense / ‘highly strung’	0.5	0.8	1.3	-0.9	1.1	0.7	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	4.9	-2.2	-0.4	-0.9	-1.0
Hair/balding pattern: Pattern 4	1.3	3.2	4.2	1.7	1.8	2.1	1.6
Birth weight of first child	0.9	1.6	4.9	2.2	0.5	0.8	0.9
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.4	-0.8	-0.6	-0.1
Pulse wave reflection index	0.1	0.2	0.4	-0.7	0.1	-0.3	-0.5
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.5	-0.1	0.1	-0.6
Loud music exposure frequency	1.0	1.1	2.1	-0.6	-1.5	-1.2	-0.8
Qualifications: O levels/GCSEs or equivalent	4.1	6.5	7.1	2.3	2.5	2.6	2.7
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	3.2	-1.3	-1.6	-1.8	-1.5
Blood clot in the leg (DVT)	0.5	0.6	1.4	-0.2	0.4	1.0	1.2
Medication: Paracetamol	0.9	1.4	1.7	-1.2	-1.2	-1.1	-1.3
Headache pain in last month	0.5	0.9	3.0	-1.7	-0.5	-0.6	-0.2
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.8	1.1	1.1	1.2	1.7
Glaucoma (self-reported)	0.7	0.8	1.9	-1.4	-0.7	-0.7	-0.6
Gout (self-reported)	0.0	0.0	0.1	-0.0	-0.3	-0.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	0.8	-0.1	-0.3	-0.1
Medication: Amlodipine	0.2	0.3	0.8	0.3	-0.1	-0.4	-0.9
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.3	-0.1	0.4	-0.1
Birth weight	3.8	8.3	10.2	2.4	3.2	3.0	2.9
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.9	-1.0	0.4	0.2	0.6
High blood pressure (siblings)	0.5	0.7	1.4	0.3	1.2	1.1	0.5
Forced vital capacity (FVC), Best measure	0.6	2.1	2.5	1.5	1.3	1.5	1.6
Body fat percentage	0.7	2.8	3.1	-1.7	-1.7	-1.8	-1.6
Leg fat percentage (right)	2.4	8.7	9.7	-2.9	-2.9	-3.1	-2.8
Arm fat-free mass (right)	0.1	0.7	1.5	1.1	-1.2	0.0	0.2
Exposure to tobacco smoke outside home	0.1	0.1	0.3	-0.6	0.3	-0.3	-0.2
Comparative body size at age 10	0.6	1.7	2.6	1.6	0.8	1.3	1.5
Number of full brothers	0.4	0.5	0.7	-0.2	-0.7	-0.8	-0.8
Worry too long after embarrassment	1.2	2.0	3.9	0.5	2.0	1.1	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	1.6	-0.8	-1.2	-1.1	-1.1
Wheeze or whistling in the chest in last year	7.9	14.0	15.7	-3.7	-3.6	-3.7	-4.0
Number of children fathered	1.7	2.0	3.5	0.9	1.9	1.1	1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	-0.7	0.1	-0.2	-0.1
Age at first live birth	2.4	4.2	5.6	1.9	2.4	2.0	2.0
Pulse wave peak to peak time	2.1	2.5	3.3	1.8	1.0	1.5	1.8
Health satisfaction	7.4	9.6	13.9	-3.7	-2.6	-3.2	-2.8
Shortness of breath walking on level ground	2.6	3.0	5.5	-1.2	-2.0	-1.2	-2.3
Qualifications: College or University degree	0.7	2.1	2.5	1.6	1.6	1.6	1.0
Eye problems/disorders: None of the above	0.7	0.8	1.2	0.4	0.9	1.1	1.1
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.0	0.5	1.4	0.5	1.3
Emphysema/chronic bronchitis	0.8	0.9	1.7	-0.0	-1.1	-0.8	-1.3
Medication for pain relief, constipation, heartburn	3.2	5.5	7.8	2.8	1.9	2.2	2.4
Neck or shoulder pain in last month	0.3	0.5	0.6	-0.8	-0.5	-0.7	-0.7
Medication: Blood pressure	0.4	0.8	1.5	-0.9	-0.4	-0.7	-1.2
Angina (self-reported)	0.3	0.3	0.8	-0.1	0.4	0.9	0.6
Migraine (self-reported)	0.0	0.0	0.1	-0.3	0.0	0.3	-0.0
Medication: Ibuprofen	1.8	2.1	2.6	-1.4	-1.6	-1.3	-1.6
Medication: Allopurinol	0.2	0.2	0.6	-0.1	0.1	0.4	0.8
Medication: Omeprazole	0.5	0.6	0.9	-1.0	-0.4	-1.0	-0.8
Medication: Seretide 50 evohaler	1.5	1.8	2.2	-1.1	-1.2	-1.5	-1.5
Mean time to correctly identify matches	0.7	1.2	3.5	0.9	1.9	0.8	0.4
Heart disease (mother)	0.1	0.1	0.1	-0.3	-0.4	-0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	-0.9	-0.5	-0.5	-0.5
Whole body fat mass	0.4	1.6	2.6	-1.1	-1.6	-1.2	-1.1
Leg fat mass (right)	1.2	4.6	6.5	-1.9	-2.5	-2.1	-1.9
Arm predicted mass (right)	0.1	0.7	2.2	0.7	-1.5	-0.3	-0.1
Pulse rate, automated reading	1.6	5.3	8.3	-2.2	-2.9	-2.0	-2.0
Alcohol intake frequency.	0.9	2.0	3.2	-1.8	-0.8	-1.4	-1.6
Comparative height size at age 10	1.6	9.0	10.4	3.2	2.7	3.2	2.9
Number of full sisters	0.5	0.6	0.9	-0.5	-0.5	-0.9	-1.0
Suffer from ‘nerves’	1.7	2.7	3.5	-1.9	-1.2	-1.7	-1.7
Overall health rating	1.0	2.2	3.4	-1.8	-1.5	-1.4	-1.2
Chest pain or discomfort	4.4	6.3	7.4	-2.6	-2.3	-2.4	-2.7
Had major operations	0.3	0.4	1.1	-1.1	-0.3	-0.3	-0.4
Age at last live birth	2.8	4.1	5.1	2.0	2.3	2.1	1.7
Family relationship satisfaction	1.3	1.7	4.3	-2.1	-1.0	-0.9	-0.7
Leg pain on walking	7.1	8.9	11.0	-2.8	-3.1	-2.7	-3.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.3	0.9	0.7	0.9	1.1
Commuting to job workplace: Car/motor vehicle	1.2	1.4	3.1	-1.8	-0.9	-1.1	-0.6
Illness, injury, bereavement, stress in last 2 years	2.7	3.2	4.1	1.7	2.0	1.6	1.8
Medication: Aspirin	0.0	0.1	0.1	-0.2	-0.1	0.4	-0.2
Supplements: Vitamin C	0.7	0.8	1.1	1.1	0.6	1.0	0.9
Knee pain experienced in last month	0.1	0.1	0.3	-0.5	-0.4	-0.2	-0.4
Hypertension (Self-reported)	0.9	2.5	3.7	-1.9	-1.0	-1.3	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.6	-0.7	-0.6	-0.8	-0.7
Illnesses of father: Heart disease	0.4	0.6	1.7	-1.3	-0.4	-0.3	-0.7
Illnesses of siblings: Diabetes	0.1	0.1	0.4	-0.1	-0.1	0.6	0.2
Smoking status: Previous	0.8	1.1	1.6	-0.7	-1.3	-1.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.5	1.2	0.4	1.1	0.9
Whole body fat-free mass	0.2	1.3	3.1	1.8	-0.1	1.1	1.1
Leg fat-free mass (right)	0.3	1.5	3.3	1.8	-0.0	1.2	1.0
Arm fat percentage (left)	0.5	2.1	2.4	-1.6	-1.4	-1.4	-1.4
Average weekly red wine intake	0.5	0.8	1.0	1.0	1.0	0.8	0.7
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.0	-1.1	-0.9	-1.2	-1.7
Mood swings	1.3	2.4	3.3	-1.8	-1.1	-1.6	-1.5
Loneliness, isolation	5.1	7.1	9.2	-2.9	-3.0	-2.5	-2.1
Long-standing illness, disability or infirmity	0.4	0.6	0.6	-0.8	-0.6	-0.8	-0.8
Ever had bowel cancer screening	0.5	0.6	1.5	0.1	1.2	0.8	0.5
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.4	-0.3	-0.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	4.1	-1.4	-2.0	-1.5	-1.8
Friendships satisfaction	0.2	0.2	0.9	-0.9	-0.0	-0.1	0.1
Qualifications: nursing, teaching	0.6	0.9	1.8	0.6	1.4	0.9	0.7
Commuting to job workplace: Walk	0.7	0.7	1.0	1.0	0.9	0.8	0.6
Eye problems/disorders: Cataract	0.1	0.1	0.1	0.4	0.2	-0.3	0.1
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	3.3	-1.5	-1.8	-1.4	-1.2
Medication for cholesterol	1.0	1.6	2.2	1.1	1.1	1.3	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	0.3	0.3	0.7	0.4
Back pain experienced in last month	0.6	0.8	1.5	-1.1	-0.6	-1.2	-0.6
Mineral and other dietary supplements	0.5	0.6	1.4	0.4	0.8	0.5	1.2
Breast cancer (self-reported)	0.4	0.5	1.4	-1.2	-0.4	-0.5	-0.3
Asthma (self-reported)	0.0	0.0	0.1	-0.2	0.1	0.1	-0.3
Osteoporosis (self-reported)	0.1	0.1	0.2	-0.0	-0.2	0.5	0.0
Osteoarthritis (self-reported)	0.2	0.2	0.5	0.2	0.0	-0.6	-0.7
Medication: Aspirin	0.7	1.0	1.8	-1.3	-0.9	-0.5	-1.0
Medication: Gliclazide	0.7	0.8	1.2	1.1	0.6	0.8	0.9
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	-0.2	-0.8	-0.9	-0.5
Smoking status: Current	0.7	1.0	3.6	-1.9	-0.4	-0.6	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.3	0.2	-0.1	-0.1	-0.6
Whole body water mass	0.3	1.5	3.3	1.8	-0.1	1.2	1.1
Leg predicted mass (right)	0.3	1.6	3.6	1.9	0.0	1.3	1.1
Arm fat mass (left)	0.7	2.9	4.3	-1.5	-2.1	-1.6	-1.6
Number of self-reported non-cancer illnesses	0.3	0.6	1.1	-0.8	-0.3	-0.8	-1.0
Average weekly champagne plus white wine intake	1.0	1.3	2.1	1.2	0.9	1.5	1.0
Miserableness	3.0	5.2	6.1	-2.5	-2.2	-2.2	-2.2
Guilty feelings	0.7	1.1	2.2	-1.5	-0.9	-1.1	-0.2
Wears glasses or contact lenses	0.0	0.0	0.0	-0.2	-0.0	0.0	-0.1
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.5	0.3	0.2	0.3
Hearing aid user	0.8	0.9	1.5	-1.2	-0.8	-0.9	-0.8
Mother’s age at death	1.9	2.4	2.7	1.5	1.6	1.6	1.4
Financial situation satisfaction	4.2	5.2	8.5	-2.9	-2.2	-2.0	-1.9
Tinnitus: Yes, now most or all of the time	1.6	1.9	2.9	-1.0	-1.2	-1.5	-1.7
Commuting to job workplace: Public transport	2.1	2.5	3.0	1.7	1.7	1.4	1.4
Eye problems/disorders: Glaucoma	2.5	3.0	3.5	-1.7	-1.9	-1.5	-1.8
Medication: Blood pressure	0.4	0.8	1.0	-1.0	-0.6	-0.9	-1.0
Pain type(s) experienced in last month: Hip pain	2.4	3.1	4.2	-2.0	-1.1	-2.0	-1.7
Supplements: Fish oil (including cod liver oil)	1.5	2.0	3.1	-1.1	-1.2	-1.4	-1.8
High cholesterol (Self-reported)	1.9	3.3	4.6	-2.0	-1.4	-2.1	-1.7
Medication: Bendroflumethiazide	0.2	0.3	0.8	-0.9	0.5	-0.4	-0.2
Medication: Paracetamol	0.2	0.3	0.6	-0.3	-0.6	-0.3	-0.8
Medication: Lisinopril	0.4	0.5	1.1	-1.1	-0.2	-0.6	-0.8
Medication: Atorvastatin	4.9	6.0	7.2	-2.7	-2.5	-2.5	-2.0
Illnesses of father: High blood pressure	3.9	4.9	5.7	-2.4	-2.1	-2.2	-2.1
Alcohol drinker status: Never	1.3	1.5	1.6	-1.2	-1.3	-1.2	-1.3
Ever smoked	0.6	1.1	1.5	-1.1	-1.2	-1.1	-0.7
Basal metabolic rate	0.1	0.7	1.7	1.3	-0.5	0.7	0.7
Leg fat percentage (left)	2.5	8.9	10.1	-2.9	-3.1	-3.2	-2.8
Arm fat-free mass (left)	0.1	0.5	1.3	0.8	-1.1	-0.0	0.2
Number of operations (self-reported)	2.6	3.8	5.3	-1.7	-2.0	-2.3	-1.7
Average weekly beer plus cider intake	0.4	0.6	1.5	-0.5	-1.2	-0.5	-0.7
Irritability	0.7	1.1	2.9	-1.7	-0.5	-1.0	-0.6
Risk taking	0.3	0.4	0.7	-0.3	-0.8	-0.7	-0.7
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.3	1.1	0.8	1.0	0.4
Fractured/broken bones in last 5 years	0.4	0.6	0.9	0.8	0.4	1.0	0.7
Age started oral contraceptive pill	0.5	0.6	1.0	1.0	1.0	0.6	0.5
Diastolic blood pressure, automated reading	0.1	0.2	0.3	-0.6	0.3	0.3	-0.4
Ever depressed for a whole week	2.4	3.0	4.5	-1.8	-0.8	-1.9	-2.1
Unable to work because of sickness or disability	0.5	0.6	1.8	-1.3	-0.4	-0.1	-0.7
Commuting to job workplace: Cycle	0.1	0.1	0.1	0.2	-0.3	-0.2	-0.4
Myopia	0.2	0.2	0.3	0.2	-0.6	-0.6	-0.5
Vascular/heart problems diagnosed by doctor	1.2	3.2	4.8	2.1	1.3	1.4	2.2
Cholesterol lowering medication	2.2	3.3	4.5	-2.1	-1.3	-2.0	-1.7
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.3	-0.6	-0.2	-0.4	-0.4
Pain experienced in last month	2.1	3.5	4.8	2.2	1.6	2.1	1.6
Supplements: Calcium	2.6	2.8	3.6	-1.1	-1.9	-1.8	-1.8
Basal cell carcinoma (self-reported)	2.5	3.0	4.7	-1.6	-1.8	-1.3	-2.2
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.8	-1.4	-0.6	-0.6	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	-0.5	-0.0	0.6	0.7
Heart disease (siblings)	0.2	0.3	0.8	-0.9	-0.3	-0.2	-0.5
Alcohol drinker status: Previous	0.2	0.3	0.7	-0.8	0.0	-0.3	-0.6
Pack years of smoking	0.1	0.1	0.1	-0.4	0.4	0.2	0.0
Impedance of whole body	0.5	2.6	7.3	0.4	2.7	1.1	1.3
Leg fat mass (left)	1.2	4.7	7.1	-1.9	-2.7	-2.1	-1.9
Arm predicted mass (left)	0.1	0.7	2.2	0.8	-1.5	-0.2	-0.1