Hub : Genes

RP11-148K1.12

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Coronary 0.306 0.1080 5.9e-03 -0.009 NA 0.005 NA -0.007 9.4e-01 NA 2.2e-01 NA 6.4e-01
2 ROSMAP Brain Pre-frontal Cortex 0.172 0.0362 1.7e-10 0.157 0.091 0.128 0.149 0.160 1.2e-19 9.2e-12 4.3e-16 1.1e-18 5.2e-20

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.1 0.2 -0.1 -0.4
Bipolar Disorder or Schizophrenia 0.3 0.6 0.7 -0.8 -0.7
Depressed Affect (Nagel 2018) 0.4 0.8 1.4 -0.4 -1.2
Depression (Nagel 2018) 0.3 0.5 0.6 -0.8 0.6
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.5 0.0 0.7
Neuroticism (Nagel 2018) 0.2 0.4 0.6 -0.8 -0.4
Schizophrenia (2018) 0.3 0.7 1.0 -1.0 -0.6
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 -0.5 0.1
Worry (Nagel 2018) 0.1 0.2 0.2 -0.5 -0.5
Alzheimer’s Disease (in mother) 0.1 0.1 0.1 0.4 0.2
Alzheimer’s Disease (in father) 1.3 1.4 2.1 -1.5 -0.8
Alzheimer’s Disease (including proxy) 0.1 0.1 0.1 -0.3 -0.3
Crohns Disease (2017) 0.1 0.2 0.3 -0.1 0.6
Irritable Bowel Disease (IBD) 0.3 0.6 0.9 -0.9 0.6
Ulcerative Colitis (UC) 0.3 0.6 1.0 -1.0 0.3
Major Depression (MDD) 0.6 0.7 1.3 0.2 -1.1
Reaction Time 1.0 1.8 3.6 1.9 -0.3
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.4 0.0 0.6
Breast Cancer 0.2 0.5 0.5 -0.7 0.7
Ovarian Cancer 0.4 0.5 0.7 0.9 0.5
Prostate Cancer 2.3 3.2 5.7 -2.4 -0.8
Age at First Birth 0.0 0.0 0.0 0.1 -0.1
Bipolar Disorder (2011) 0.7 0.7 1.0 0.6 -1.0
Body Mass Index (BMI) (2010) 0.0 0.1 0.1 -0.3 0.2
Coronary Artery Disease (CAD) 0.1 0.1 0.2 0.1 -0.5
Crohns Disease (2012) 0.1 0.2 0.4 -0.6 -0.3
Mean Putamen Volume 1.3 1.5 2.9 0.2 1.7
Fasting Glucose 1.3 1.6 2.9 -1.7 0.5
HbA1C 0.0 0.0 0.1 0.3 0.1
HDL Cholesterol 0.8 1.3 2.5 0.2 -1.6
LDL Cholesterol 0.4 0.7 1.2 0.4 -1.1
Lupus 0.1 0.1 0.2 0.1 -0.4
Neuroticism (2016) 0.0 0.0 0.1 0.1 -0.3
Primary Biliary Cirrhosis 2.2 3.2 6.0 -0.6 -2.4
Rheumatoid Arthritis 2.1 2.8 3.4 -1.5 -1.9
Schizophrenia (2014) 0.6 1.4 2.7 -1.6 -0.4
Triglycerides 0.1 0.1 0.2 -0.4 0.3
Type 2 Diabetes (T2D) (2012) 1.1 1.3 2.6 0.1 1.6
Ulcerative Colitis 1.0 1.5 2.9 -1.7 0.4
Blood Eosinophil Count 0.2 1.2 1.8 -1.4 0.7
Blood Platelet Count 0.0 0.5 0.5 0.6 -0.7
Blood Red Count 3.0 28.9 44.0 -3.7 6.6
Blood White Count 0.2 1.4 1.8 -1.3 1.0
Heel T-Score 1.3 10.5 20.0 -1.0 -4.5
BMI 0.6 3.5 6.6 -0.7 2.6
Height 4.5 86.5 151.3 -12.3 4.7
Waist Hip Ratio (WHR) 0.6 2.6 3.8 -2.0 1.2
Systolic Blood Pressure 0.4 2.1 2.5 1.3 -1.6
Smoking Status 0.0 0.1 0.2 -0.4 -0.1
Allergy or Eczema 3.2 8.5 13.7 1.8 3.7
Cardiovascular Disease 0.7 2.4 2.8 -1.7 -1.4
Hypothyroidism (self reported) 0.7 1.5 2.0 1.0 1.4
Respiratory disease 0.3 0.8 0.9 0.9 0.8
Type 2 Diabetes (T2D) (2018) 1.5 2.9 5.6 -2.4 -0.4
Lung FEV1/FVC ratio 2.2 10.9 19.9 1.4 4.5
Lung FVC 3.7 19.0 20.9 -4.6 -4.1
Neuroticism 0.1 0.3 0.5 -0.7 -0.2
Chronotype (morning person) 0.7 1.5 2.6 -1.6 0.7
Hair Pigment 0.2 6.6 12.5 0.8 3.5
Tanning 0.1 1.0 1.4 -0.8 1.2
Hand grip strength (left) 4.3 11.3 22.6 -4.8 -0.3
Number of treatments/medications taken 0.9 1.7 1.8 1.2 1.3
Average weekly spirits intake 0.1 0.1 0.2 -0.1 0.4
Sensitivity / hurt feelings 0.0 0.0 0.0 0.1 -0.1
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.1 -0.3 -0.3
Hearing difficulty/problems: Yes 0.4 0.7 0.9 -0.6 1.0
Relative age of first facial hair 0.6 1.2 2.2 0.3 1.5
Other serious medical condition/disability diagnosed by doctor 1.7 2.1 2.2 -1.5 1.5
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.6 -0.8 -0.3
Ever had hysterectomy (womb removed) 0.3 0.3 0.6 0.3 0.8
Systolic blood pressure, automated reading 0.6 1.9 3.3 1.8 -0.7
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 1.7 -1.3 -0.1
Angina 0.5 0.6 1.0 -1.0 -0.5
Medication for hormone replacement therapy 0.6 0.7 1.2 1.1 0.4
Vitamin and mineral supplements 2.7 3.6 4.2 2.0 1.8
Supplements: Zinc 0.1 0.2 0.3 -0.2 0.5
Medication: Co-codamol 0.5 0.6 0.8 0.6 0.9
Medication: Metformin 1.7 2.3 4.5 -2.1 -0.5
Diabetes (father) 0.4 0.5 0.9 -0.9 -0.2
Diabetes (mother) 0.3 0.4 0.5 -0.7 0.6
Severe depression (siblings) 0.3 0.3 0.6 0.1 0.8
Pack years adult smoking proportion 0.8 1.2 1.5 -0.9 -1.2
Impedance of leg (right) 5.9 28.7 41.0 6.4 -4.0
Leg fat-free mass (left) 7.0 37.1 39.1 -6.2 5.9
Trunk fat percentage 1.2 4.8 4.9 2.2 2.2
Hand grip strength (right) 4.4 12.0 23.0 -4.8 1.0
Townsend deprivation index at recruitment 1.2 1.7 2.5 1.6 -1.0
Current tobacco smoking 0.3 0.4 0.7 0.8 -0.4
Average weekly fortified wine intake 0.3 0.4 0.6 0.8 0.3
Maternal smoking around birth 0.3 0.5 1.0 1.0 0.2
Fed-up feelings 0.4 0.8 1.6 -0.1 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.5 0.3 0.7
Relative age voice broke 0.7 1.0 1.5 -0.7 1.2
Taking other prescription medications 0.3 0.5 0.9 -0.2 0.9
Age when periods started (menarche) 0.3 0.7 0.8 0.7 0.9
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 3.4 -0.7 1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.4 0.6 -0.4
Tinnitus: Yes, but not now, but have in the past 2.2 2.3 3.3 -1.1 -1.8
Qualifications: CSEs or equivalent 1.2 1.6 2.3 0.9 -1.5
Serious illness, injury or assault to yourself 1.0 1.2 2.3 -1.5 0.4
High blood pressure 0.7 2.1 3.1 -1.8 -1.0
Hayfever, allergic rhinitis or eczema 2.8 6.1 8.2 2.0 2.9
Multivitamins +/- minerals 0.9 1.2 2.1 -0.5 -1.5
Stomach or abdominal pain in last month 0.4 0.5 0.7 -0.9 0.6
Supplements: Glucosamine 1.0 1.3 2.5 0.3 -1.6
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 0.7 -0.0
Medication: Atenolol 1.3 1.6 1.8 -1.4 -1.2
Medication: Levothyroxine sodium 0.6 1.1 1.7 0.7 1.3
Sitting height 4.4 31.1 38.1 -6.2 4.9
Chronic bronchitis/emphysema (father) 0.8 0.9 1.8 -1.3 0.2
High blood pressure (mother) 0.7 1.0 1.9 -1.4 0.3
Body mass index (BMI) 1.2 5.1 8.7 -1.2 3.0
Impedance of leg (left) 5.8 28.2 39.3 6.3 -4.1
Leg predicted mass (left) 7.0 36.9 38.7 -6.2 5.9
Trunk fat mass 1.5 6.3 12.7 -0.1 3.6
Waist circumference 3.8 14.1 19.4 -3.0 4.4
Number of incorrect matches in round 0.6 0.9 1.1 -0.9 -1.1
Past tobacco smoking 0.9 1.6 3.2 1.8 -0.1
Alcohol usually taken with meals 1.1 1.8 2.0 1.3 1.4
Nervous feelings 0.7 1.4 2.0 -0.8 -1.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 0.9 0.1 1.0
Hearing difficulty/problems with background noise 0.1 0.1 0.2 0.3 -0.4
Hair/balding pattern: Pattern 2 1.0 1.2 1.6 1.3 0.9
Had menopause 0.0 0.0 0.1 0.1 0.3
Had other major operations 0.6 0.7 1.3 -1.2 0.2
Forced vital capacity (FVC) 2.8 10.9 21.7 -4.7 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 1.6 0.1 -1.3
Ever unenthusiastic/disinterested for a whole week 3.6 4.4 8.4 0.6 -2.9
Qualifications: None of the above 1.6 3.4 6.7 -0.2 -2.6
Financial difficulties in last 2 years 0.4 0.5 1.0 -1.0 -0.2
Mouth/teeth dental problems 0.7 1.1 1.8 -0.5 -1.4
Heart attack 0.7 0.9 1.6 -1.3 -0.5
Allergy 2.3 5.2 8.5 -1.4 -2.9
Pain all over the body in last month 0.1 0.1 0.1 -0.3 -0.3
Diabetes (self-reported) 1.9 2.9 5.7 -2.4 0.4
Hayfever/allergic rhinitis (self-reported) 2.1 2.8 4.2 2.0 1.2
Medication: Ramipril 1.3 1.7 1.8 -1.4 -1.3
Medication: Simvastatin 0.4 0.6 1.1 -1.1 -0.2
Fluid intelligence score 0.2 0.4 0.8 0.2 0.9
Illnesses of siblings 0.0 0.0 0.0 0.1 -0.1
Neuroticism score 0.2 0.4 0.7 -0.8 -0.3
Weight 4.4 21.8 23.8 -4.5 4.9
Impedance of arm (right) 4.8 22.3 34.0 5.8 -3.3
Arm fat percentage (right) 0.7 2.6 3.5 1.9 1.3
Trunk fat-free mass 8.3 47.7 63.8 -8.0 5.6
Hip circumference 2.5 11.0 15.2 -2.6 3.9
Time employed in main current job 5.9 6.8 13.4 0.6 3.7
Alcohol intake versus 10 years previously 0.2 0.3 0.6 -0.8 -0.1
Father’s age at death 0.2 0.3 0.3 -0.6 0.5
Worrier / anxious feelings 1.0 1.9 3.6 -1.9 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.0 -0.4 1.0
Falls in the last year 0.8 1.1 2.0 -0.4 1.4
Hair/balding pattern: Pattern 3 2.9 4.4 6.3 -1.6 -2.5
Number of live births 0.2 0.3 0.5 0.7 -0.3
Forced expiratory volume in 1-second (FEV1) 2.3 7.7 15.0 -3.9 0.7
Pulse rate 3.5 5.9 11.6 3.4 -0.5
Happiness 0.0 0.0 0.0 0.2 0.2
Noisy workplace 1.2 1.5 1.8 -1.3 -1.1
Qualifications: A levels/AS levels or equivalent 0.5 1.2 1.9 -1.4 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 0.7 0.6 0.8
Mouth/teeth dental problems: Dentures 0.5 0.8 0.8 0.9 0.9
Asthma 1.4 2.8 4.7 1.0 2.2
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.7 0.5 0.8
Medication: Cholesterol lowering 0.7 1.1 2.1 -1.4 -0.5
Depression (self-reported) 3.2 3.8 4.6 1.8 -2.1
Medication: Lansoprazole 0.5 0.6 0.7 0.6 0.8
Prospective memory result 0.3 0.4 0.6 -0.4 0.8
Lung cancer (father) 0.4 0.4 0.8 -0.2 0.9
Illnesses of mother 0.2 0.2 0.3 0.3 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.7 10.4 -3.2 1.1
Pulse wave Arterial Stiffness index 1.5 1.8 3.3 0.5 1.8
Impedance of arm (left) 4.8 22.4 35.4 6.0 -3.1
Arm fat mass (right) 1.2 5.0 9.1 -0.9 3.0
Trunk predicted mass 8.3 47.6 63.0 -7.9 5.7
Standing height 3.7 36.6 51.1 -7.2 4.7
Length of working week for main job 1.3 1.5 1.7 1.1 1.3
Exposure to tobacco smoke at home 0.5 0.6 1.1 1.1 -0.1
Breastfed as a baby 0.6 0.7 1.2 -1.1 -0.5
Tense / ‘highly strung’ 0.1 0.1 0.2 0.1 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.2 4.6 -1.3 -2.1
Hair/balding pattern: Pattern 4 0.8 2.0 2.7 -1.6 1.2
Birth weight of first child 0.2 0.3 0.6 -0.1 -0.8
Peak expiratory flow (PEF) 0.6 1.3 2.0 -1.4 0.8
Pulse wave reflection index 1.6 2.0 2.2 -1.5 1.3
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.5 -1.6 -0.1
Loud music exposure frequency 2.1 2.3 2.7 -1.4 -1.6
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.3 -0.2 1.1
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 1.1 -1.0 1.0
Blood clot in the leg (DVT) 1.0 1.3 1.4 -1.2 1.1
Medication: Paracetamol 1.4 2.2 4.4 2.1 0.4
Headache pain in last month 0.7 1.1 2.0 0.5 -1.4
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.3 0.5 0.0
Glaucoma (self-reported) 0.2 0.2 0.4 -0.2 0.6
Gout (self-reported) 0.1 0.2 0.4 0.6 -0.0
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 1.4 1.1 1.2
Medication: Amlodipine 1.8 2.5 5.1 -2.2 0.1
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.4 0.6 0.1
Birth weight 0.1 0.1 0.3 0.5 -0.1
Chronic bronchitis/emphysema (mother) 1.5 1.7 3.2 1.8 0.4
High blood pressure (siblings) 0.4 0.5 1.0 -1.0 -0.1
Forced vital capacity (FVC), Best measure 2.4 8.7 17.3 -4.2 -0.3
Body fat percentage 1.2 4.9 5.9 2.4 2.0
Leg fat percentage (right) 1.2 4.3 6.6 2.6 1.4
Arm fat-free mass (right) 8.1 41.6 50.6 -7.1 5.7
Exposure to tobacco smoke outside home 0.1 0.1 0.2 0.2 0.4
Comparative body size at age 10 0.2 0.7 1.2 0.4 1.1
Number of full brothers 0.1 0.1 0.2 0.0 -0.4
Worry too long after embarrassment 0.9 1.5 3.0 -1.7 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 3.5 -0.9 -1.9
Wheeze or whistling in the chest in last year 0.8 1.5 2.9 1.7 0.2
Number of children fathered 0.0 0.0 0.1 0.1 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.2 -0.4 -0.1
Age at first live birth 0.0 0.1 0.1 -0.4 -0.1
Pulse wave peak to peak time 1.4 1.6 1.8 -1.2 -1.4
Health satisfaction 1.1 1.5 3.0 -0.0 1.7
Shortness of breath walking on level ground 0.5 0.6 1.2 -1.1 0.1
Qualifications: College or University degree 1.1 3.3 6.6 -0.2 2.6
Eye problems/disorders: None of the above 0.7 0.8 1.1 1.1 -0.7
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.4 0.6 0.0
Emphysema/chronic bronchitis 2.5 2.8 5.5 -0.4 -2.3
Medication for pain relief, constipation, heartburn 0.6 1.1 2.1 0.1 -1.4
Neck or shoulder pain in last month 0.4 0.5 0.8 0.5 -0.9
Medication: Blood pressure 0.2 0.3 0.6 0.1 0.8
Angina (self-reported) 0.5 0.7 1.2 -1.1 -0.5
Migraine (self-reported) 2.1 2.6 5.1 0.4 2.2
Medication: Ibuprofen 0.2 0.2 0.4 -0.0 0.6
Medication: Allopurinol 0.0 0.0 0.0 0.1 0.2
Medication: Omeprazole 3.3 4.0 4.8 -1.8 2.2
Medication: Seretide 50 evohaler 0.3 0.4 0.7 0.3 -0.9
Mean time to correctly identify matches 0.5 1.0 1.9 1.4 0.4
Heart disease (mother) 0.1 0.2 0.3 0.6 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.5 -0.3 0.7
Whole body fat mass 1.4 6.0 11.9 -0.3 3.5
Leg fat mass (right) 1.3 4.9 9.8 -0.3 3.1
Arm predicted mass (right) 8.0 41.1 49.0 -7.0 5.8
Pulse rate, automated reading 4.0 12.9 23.2 4.8 1.6
Alcohol intake frequency. 0.2 0.4 0.7 -0.8 0.4
Comparative height size at age 10 2.7 14.9 16.8 -4.1 3.6
Number of full sisters 0.8 0.9 1.2 -1.1 0.8
Suffer from ‘nerves’ 0.0 0.0 0.1 0.2 -0.3
Overall health rating 0.2 0.3 0.6 -0.8 0.1
Chest pain or discomfort 0.3 0.4 0.7 -0.4 0.8
Had major operations 1.0 1.2 1.9 -1.4 0.7
Age at last live birth 1.9 2.8 5.6 2.4 0.1
Family relationship satisfaction 0.3 0.4 0.6 0.3 -0.8
Leg pain on walking 0.5 0.7 1.3 -1.1 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 1.1 1.1 0.9
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.4 -0.6 -0.1
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 2.8 -0.5 -1.7
Medication: Aspirin 0.8 1.0 1.5 -1.2 -0.7
Supplements: Vitamin C 2.5 2.9 3.1 -1.6 -1.8
Knee pain experienced in last month 1.7 2.7 4.4 1.0 2.1
Hypertension (Self-reported) 1.0 2.9 4.1 -2.0 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.5 2.9 3.6 -1.5 1.9
Illnesses of father: Heart disease 1.8 2.5 3.0 1.7 -1.4
Illnesses of siblings: Diabetes 1.1 1.4 1.9 -1.4 -0.9
Smoking status: Previous 0.8 1.2 1.9 -1.4 0.7
Forced expiratory volume in 1-second (FEV1), predicted 3.9 8.2 11.7 -3.4 2.2
Whole body fat-free mass 8.2 46.6 56.7 -7.5 6.0
Leg fat-free mass (right) 7.3 39.0 45.0 -6.7 5.7
Arm fat percentage (left) 0.8 3.4 3.5 1.9 1.8
Average weekly red wine intake 0.5 0.7 1.2 1.1 -0.5
Handedness (chirality/laterality): Left-handed 0.9 1.0 1.3 -0.9 1.1
Mood swings 0.0 0.0 0.0 -0.2 -0.1
Loneliness, isolation 0.7 1.0 1.2 -0.9 1.1
Long-standing illness, disability or infirmity 0.2 0.3 0.3 -0.5 0.5
Ever had bowel cancer screening 0.2 0.3 0.5 -0.4 -0.7
Diabetes diagnosed by doctor 3.1 5.1 10.0 -3.2 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.5 0.6 0.7
Friendships satisfaction 0.5 0.6 0.9 -1.0 0.5
Qualifications: nursing, teaching 0.2 0.4 0.5 -0.7 -0.5
Commuting to job workplace: Walk 2.1 2.3 4.4 2.1 0.3
Eye problems/disorders: Cataract 0.7 0.9 1.2 -1.1 0.7
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 1.6 -1.3 0.9
Medication for cholesterol 0.3 0.4 0.9 0.9 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 1.6 0.3 1.3
Back pain experienced in last month 0.1 0.2 0.3 -0.6 -0.3
Mineral and other dietary supplements 0.4 0.6 1.1 0.2 1.1
Breast cancer (self-reported) 0.3 0.3 0.7 -0.8 0.2
Asthma (self-reported) 1.4 2.7 4.5 1.0 2.1
Osteoporosis (self-reported) 0.2 0.3 0.5 0.3 -0.7
Osteoarthritis (self-reported) 2.2 2.9 4.0 1.3 2.0
Medication: Aspirin 0.9 1.2 1.8 -1.4 -0.7
Medication: Gliclazide 1.4 1.6 3.2 0.0 -1.8
Illnesses of father: None of the above (group 1) 0.6 0.8 1.2 -0.6 1.1
Smoking status: Current 0.6 0.9 1.6 1.3 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.3 -0.4 -0.6
Whole body water mass 8.2 47.0 57.5 -7.6 6.0
Leg predicted mass (right) 7.2 38.6 44.6 -6.7 5.7
Arm fat mass (left) 1.3 5.3 9.8 -0.9 3.1
Number of self-reported non-cancer illnesses 0.7 1.3 1.7 -1.3 0.9
Average weekly champagne plus white wine intake 0.4 0.6 0.9 -0.5 1.0
Miserableness 0.2 0.3 0.5 -0.2 -0.7
Guilty feelings 0.8 1.2 2.2 -0.5 1.5
Wears glasses or contact lenses 0.9 1.1 1.5 -1.2 0.8
Ever taken oral contraceptive pill 0.5 0.5 1.0 -0.1 1.0
Hearing aid user 0.6 0.7 1.0 0.6 -1.0
Mother’s age at death 3.0 3.8 4.0 -1.9 2.0
Financial situation satisfaction 1.0 1.2 1.4 -1.0 1.2
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.1 0.3 -0.4
Commuting to job workplace: Public transport 0.3 0.4 0.7 0.8 0.4
Eye problems/disorders: Glaucoma 1.0 1.2 1.6 0.9 1.3
Medication: Blood pressure 1.2 2.3 3.9 -2.0 -0.9
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.5 0.2 1.2
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.6 -0.8 -0.4
High cholesterol (Self-reported) 0.2 0.3 0.6 0.2 -0.8
Medication: Bendroflumethiazide 0.5 0.7 1.3 -0.3 1.2
Medication: Paracetamol 1.1 1.7 3.4 1.8 -0.1
Medication: Lisinopril 0.5 0.7 1.2 -1.1 0.4
Medication: Atorvastatin 1.9 2.4 4.6 -0.5 -2.1
Illnesses of father: High blood pressure 0.0 0.0 0.1 0.3 -0.1
Alcohol drinker status: Never 0.3 0.3 0.6 -0.3 0.8
Ever smoked 0.5 0.8 1.6 -1.3 -0.1
Basal metabolic rate 7.4 40.9 48.0 -6.9 5.8
Leg fat percentage (left) 1.1 4.0 6.3 2.5 1.3
Arm fat-free mass (left) 7.5 37.9 48.3 -7.0 5.2
Number of operations (self-reported) 3.1 4.6 7.7 -1.3 2.8
Average weekly beer plus cider intake 0.3 0.5 0.6 0.8 -0.6
Irritability 0.3 0.5 0.9 -1.0 0.0
Risk taking 0.6 0.9 1.0 -0.8 -1.0
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.0 -1.4 -0.0
Fractured/broken bones in last 5 years 0.7 0.9 1.0 1.0 0.9
Age started oral contraceptive pill 0.3 0.3 0.3 -0.6 0.6
Diastolic blood pressure, automated reading 2.1 6.4 12.8 3.6 0.3
Ever depressed for a whole week 0.8 1.0 1.9 -1.4 0.2
Unable to work because of sickness or disability 0.4 0.5 0.5 0.7 -0.7
Commuting to job workplace: Cycle 0.4 0.4 0.6 0.7 0.6
Myopia 0.5 0.7 1.1 -0.5 -1.0
Vascular/heart problems diagnosed by doctor 0.7 2.0 3.3 1.8 0.9
Cholesterol lowering medication 0.4 0.7 1.2 -0.3 -1.1
Medication: Omeprazole (e.g. Zanprol) 2.7 3.2 4.3 -1.5 2.1
Pain experienced in last month 0.5 0.8 1.5 -1.2 0.3
Supplements: Calcium 0.1 0.1 0.2 -0.4 0.2
Basal cell carcinoma (self-reported) 0.2 0.2 0.4 0.1 0.6
Heart attack/myocardial infarction (self-reported) 0.8 1.0 1.7 -1.3 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 1.3 -1.2 0.8
Heart disease (siblings) 0.7 0.8 1.2 1.1 0.6
Alcohol drinker status: Previous 1.0 1.2 2.3 -1.5 -0.1
Pack years of smoking 1.1 1.6 1.8 -1.3 -1.2
Impedance of whole body 5.4 27.4 41.4 6.4 -3.7
Leg fat mass (left) 1.2 4.7 9.3 -0.4 3.0
Arm predicted mass (left) 7.6 38.8 47.2 -6.9 5.5