Hub : Genes

RP11-157P1.5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.154	0.0464	3.3e-04	0.060	NA	0.029	NA	0.026	1.8e-05	NA	2.2e-03	NA	3.9e-03
2	GTEx	Cells Transformed fibroblasts	0.150	0.0400	2.3e-05	0.124	NA	0.099	NA	0.094	1.6e-09	NA	7.3e-08	NA	1.7e-07
3	GTEx	Heart Atrial Appendage	0.293	0.0650	5.3e-08	0.222	NA	0.158	NA	0.213	2.5e-10	NA	1.4e-07	NA	6.1e-10
4	GTEx	Heart Left Ventricle	0.213	0.0560	1.8e-06	0.080	NA	0.133	NA	0.140	4.9e-05	NA	1.4e-07	NA	6.5e-08
5	GTEx	Liver	0.391	0.0860	5.5e-07	0.180	NA	0.265	NA	0.272	9.7e-06	NA	4.8e-08	NA	3.1e-08
6	GTEx	Muscle Skeletal	0.138	0.0406	1.6e-05	0.024	NA	0.022	NA	0.020	1.7e-03	NA	2.8e-03	NA	4.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.3	2.1	6.0	0.8	0.6	-1.8	-2.5	-1.3	-0.5
Bipolar Disorder or Schizophrenia	1.4	3.3	7.1	0.5	1.4	-2.6	-2.7	-1.6	-1.0
Depressed Affect (Nagel 2018)	0.8	1.7	2.7	-1.7	0.3	1.5	1.3	1.5	1.0
Depression (Nagel 2018)	0.0	0.1	0.2	0.4	-0.3	-0.1	-0.1	-0.2	-0.2
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.4	-2.1	1.7	1.2	1.3	1.4	0.7
Neuroticism (Nagel 2018)	0.3	0.7	1.9	-1.4	0.5	0.7	0.1	0.9	0.8
Schizophrenia (2018)	0.7	1.4	2.9	0.0	1.2	-1.7	-1.5	-1.0	-0.8
Schizophrenia vs Biploar Disorder	2.5	3.3	5.3	-2.0	0.0	1.9	2.3	2.2	1.5
Worry (Nagel 2018)	0.1	0.3	1.2	-0.0	0.4	-0.4	-1.1	-0.3	-0.4
Alzheimer’s Disease (in mother)	0.2	0.3	0.9	0.3	-0.7	0.1	0.2	0.1	-1.0
Alzheimer’s Disease (in father)	0.4	0.5	1.6	-0.0	-0.3	-1.3	-0.7	-0.6	-0.5
Alzheimer’s Disease (including proxy)	0.9	1.3	2.3	1.0	-1.1	-1.3	-1.0	-0.9	-1.5
Crohns Disease (2017)	0.5	1.2	2.0	1.2	-0.2	-1.0	-0.7	-1.4	-1.4
Irritable Bowel Disease (IBD)	0.7	1.7	3.0	1.7	-0.3	-1.4	-1.0	-1.5	-1.3
Ulcerative Colitis (UC)	0.8	1.5	2.8	1.7	-0.5	-1.5	-1.1	-1.2	-1.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	6.7	12.7	19.5	2.6	-1.7	-4.4	-4.1	-4.3	-3.4
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.7	-1.2	1.6	0.0	0.4	0.1	0.7
Breast Cancer	0.9	2.0	3.1	1.5	-1.8	-1.5	-1.0	-1.6	-1.0
Ovarian Cancer	0.8	1.1	2.4	0.1	-0.1	-1.6	-0.9	-1.2	-1.2
Prostate Cancer	0.7	1.0	4.0	0.4	0.1	-0.6	-0.5	-0.9	-2.0
Age at First Birth	0.1	0.2	0.6	-0.8	0.6	-0.3	-0.3	-0.4	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.1	0.6	0.2	-0.2	0.1	-0.0
Coronary Artery Disease (CAD)	0.1	0.1	0.5	-0.4	-0.1	0.2	0.1	-0.1	-0.7
Crohns Disease (2012)	0.3	0.4	1.9	0.6	1.4	-0.1	-0.1	-0.3	-0.2
Mean Putamen Volume	0.2	0.3	0.5	-0.7	0.5	0.4	0.5	0.0	-0.6
Fasting Glucose	2.3	2.8	7.0	-1.0	0.7	2.2	2.6	1.7	0.7
HbA1C	2.8	3.2	6.4	2.5	-1.5	-1.3	-1.2	-1.6	-2.1
HDL Cholesterol	0.4	0.7	1.3	0.7	-1.1	-0.8	-0.5	-1.0	-0.8
LDL Cholesterol	0.6	0.9	2.1	-1.3	0.8	0.4	1.4	0.8	0.7
Lupus	0.4	0.6	1.3	-1.1	0.1	0.6	0.3	0.8	1.1
Neuroticism (2016)	0.2	0.3	1.1	-0.7	1.0	0.3	-0.1	0.6	0.2
Primary Biliary Cirrhosis	0.9	1.3	2.6	0.0	1.4	1.6	0.8	1.3	0.8
Rheumatoid Arthritis	1.3	1.7	2.3	-1.4	1.3	1.2	1.0	1.5	1.5
Schizophrenia (2014)	0.6	1.4	3.7	0.0	1.4	-1.9	-1.3	-0.9	-0.2
Triglycerides	0.3	0.5	1.2	-0.5	0.7	0.8	1.1	0.7	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	-0.2	0.2	0.6	-0.1	0.4	-0.3
Ulcerative Colitis	0.3	0.4	1.5	1.2	-0.4	-0.3	-0.5	-0.3	-0.7
Blood Eosinophil Count	0.3	2.0	3.1	1.2	-1.0	-1.8	-1.7	-1.7	-0.9
Blood Platelet Count	2.8	32.6	39.4	6.3	-5.4	-5.2	-5.1	-6.3	-5.9
Blood Red Count	0.2	1.5	4.8	-0.8	2.2	0.6	-0.1	1.1	1.5
Blood White Count	1.1	7.9	14.6	2.3	-3.8	-2.5	-2.2	-3.3	-2.5
Heel T-Score	1.6	13.0	16.8	2.4	-3.4	-4.0	-3.9	-4.1	-3.4
BMI	0.1	0.4	1.2	-0.6	0.3	0.4	1.1	0.3	0.7
Height	2.8	53.7	71.7	-7.5	7.1	7.7	5.8	8.5	7.2
Waist Hip Ratio (WHR)	0.2	0.9	2.7	0.3	-0.3	-1.6	-0.1	-1.5	-0.7
Systolic Blood Pressure	1.6	7.8	12.6	-3.5	-0.0	3.1	3.4	2.7	2.5
Smoking Status	2.9	6.9	13.5	-1.2	1.3	3.7	3.0	2.9	2.7
Allergy or Eczema	0.6	1.5	3.3	-1.0	1.6	0.8	1.8	1.2	0.6
Cardiovascular Disease	1.1	3.7	6.7	-2.6	1.6	1.3	2.2	1.5	1.9
Hypothyroidism (self reported)	0.2	0.5	2.1	-0.2	-0.3	0.6	1.5	0.7	0.2
Respiratory disease	0.2	0.3	1.1	1.1	0.0	0.5	0.1	0.5	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	0.2	-0.5	0.7	0.4	-0.1	-0.6
Lung FEV1/FVC ratio	2.2	11.4	28.9	3.9	-5.4	-2.5	-3.3	-2.6	-0.3
Lung FVC	0.2	0.9	3.5	0.6	1.9	0.6	-0.3	0.7	0.8
Neuroticism	0.5	1.2	2.4	-1.6	1.0	1.1	0.5	1.2	0.9
Chronotype (morning person)	0.2	0.4	1.1	-0.6	-0.9	1.1	0.2	0.3	-0.2
Hair Pigment	0.1	2.4	5.0	-1.2	2.2	1.2	1.7	1.2	1.5
Tanning	0.0	0.2	0.8	-0.6	0.3	-0.2	-0.9	-0.2	-0.1
Hand grip strength (left)	1.2	3.2	6.7	-1.4	1.2	1.8	1.0	2.3	2.6
Number of treatments/medications taken	3.2	5.8	9.9	-2.4	2.3	2.3	3.2	2.1	1.9
Average weekly spirits intake	0.3	0.3	0.7	0.1	-0.8	0.6	0.4	0.8	0.3
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.4	-0.1	0.2	-0.1	0.3	-0.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.0	-0.1	-0.1	1.0	0.5	0.6	0.1
Hearing difficulty/problems: Yes	1.8	2.7	4.5	-1.1	1.4	1.7	2.1	1.9	1.6
Relative age of first facial hair	0.2	0.5	1.1	-1.1	1.0	-0.0	0.3	0.4	0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.1	0.4	1.1	-0.4	-0.4	-0.4	-0.1
Ever used hormone-replacement therapy (HRT)	2.1	2.6	3.9	-1.2	2.0	1.4	1.7	1.8	1.5
Ever had hysterectomy (womb removed)	0.8	0.9	1.3	-0.5	1.1	0.8	0.9	1.1	1.0
Systolic blood pressure, automated reading	0.5	1.5	3.0	-1.2	-0.4	1.7	1.7	1.0	0.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.9	-0.7	0.1	1.4	1.4	0.8	-0.1
Angina	0.1	0.1	0.5	-0.0	0.2	0.1	-0.3	-0.3	-0.7
Medication for hormone replacement therapy	1.7	1.9	2.8	-1.7	1.4	1.1	1.5	1.5	1.0
Vitamin and mineral supplements	0.2	0.3	0.7	-0.9	-0.1	-0.3	0.5	0.4	0.8
Supplements: Zinc	0.3	0.3	0.8	0.1	-0.8	-0.2	-0.0	-0.6	-0.9
Medication: Co-codamol	0.2	0.2	0.7	-0.4	-0.5	-0.8	0.1	-0.6	-0.1
Medication: Metformin	0.3	0.5	1.5	-0.1	-0.6	1.2	1.0	0.3	-0.3
Diabetes (father)	1.3	1.6	3.9	1.0	0.3	-2.0	-1.6	-1.4	-0.4
Diabetes (mother)	0.3	0.3	0.8	0.1	0.6	-0.6	-0.9	-0.6	-0.2
Severe depression (siblings)	0.7	0.8	1.9	0.0	-1.4	-1.2	-0.7	-0.9	-0.3
Pack years adult smoking proportion	0.2	0.3	0.7	0.8	-0.7	0.5	-0.4	0.2	0.3
Impedance of leg (right)	0.0	0.2	0.7	0.0	0.0	0.5	-0.2	0.2	-0.8
Leg fat-free mass (left)	1.1	6.0	8.1	-2.3	2.4	2.3	2.3	2.5	2.9
Trunk fat percentage	0.1	0.5	1.4	-0.3	0.6	0.8	1.2	0.6	0.1
Hand grip strength (right)	4.0	10.8	15.6	-3.1	2.1	3.7	2.6	4.0	3.8
Townsend deprivation index at recruitment	3.3	4.7	7.4	-1.7	1.8	2.4	2.7	2.3	1.8
Current tobacco smoking	0.2	0.3	0.9	0.6	-0.2	0.9	0.3	0.4	0.4
Average weekly fortified wine intake	1.3	1.5	3.5	0.9	-0.5	-1.5	-1.9	-1.4	-0.4
Maternal smoking around birth	0.1	0.2	0.8	0.9	0.1	0.5	-0.1	-0.1	-0.0
Fed-up feelings	2.9	5.2	8.6	-2.4	0.3	2.9	2.9	2.6	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.3	-1.2	0.9	1.8	1.6	1.6	1.3
Relative age voice broke	0.1	0.2	0.5	0.4	-0.7	-0.3	-0.1	-0.3	-0.6
Taking other prescription medications	7.1	11.0	16.8	-2.7	3.1	3.9	4.1	3.4	2.6
Age when periods started (menarche)	0.3	0.8	1.3	0.2	0.1	-1.1	-0.9	-1.1	-1.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	0.9	-0.4	0.1	-0.4	0.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	6.3	1.4	-2.5	0.1	-0.7	-0.4	0.2
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.7	-0.6	1.3	0.8	1.1	0.5	1.3
Qualifications: CSEs or equivalent	0.1	0.2	0.4	-0.5	0.3	0.0	0.2	0.4	0.6
Serious illness, injury or assault to yourself	0.2	0.2	1.0	0.2	0.1	1.0	0.3	0.5	-0.1
High blood pressure	1.6	4.4	9.8	-3.1	2.0	1.7	2.3	1.7	1.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.9	-0.7	1.7	0.3	1.4	0.7	0.8
Multivitamins +/- minerals	0.5	0.6	1.5	-0.3	1.0	1.2	0.9	0.6	0.2
Stomach or abdominal pain in last month	1.2	1.5	5.6	-1.0	2.4	0.7	0.4	0.9	0.9
Supplements: Glucosamine	1.5	2.0	3.6	-1.6	1.4	1.4	1.9	1.2	0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.6	-0.1	-0.5	-0.7	0.0	-0.6	-0.7
Medication: Atenolol	2.6	3.3	5.1	-2.2	1.7	2.0	1.7	1.8	1.3
Medication: Levothyroxine sodium	0.5	0.8	2.8	-1.0	-0.0	0.9	1.7	0.6	-0.1
Sitting height	0.6	4.0	9.8	-2.1	1.6	1.7	0.7	2.1	3.1
Chronic bronchitis/emphysema (father)	0.6	0.7	2.3	0.9	-0.3	0.1	-0.4	-0.8	-1.5
High blood pressure (mother)	1.3	1.8	3.8	-1.6	2.0	1.3	1.1	1.2	0.6
Body mass index (BMI)	0.2	0.8	2.6	-0.5	0.6	0.8	1.6	0.7	0.7
Impedance of leg (left)	0.0	0.2	0.5	0.2	-0.3	0.1	-0.7	-0.0	-0.5
Leg predicted mass (left)	1.2	6.2	8.4	-2.3	2.4	2.4	2.4	2.5	2.9
Trunk fat mass	0.6	2.6	4.0	-1.2	1.4	1.8	2.0	1.7	1.4
Waist circumference	0.5	1.7	3.6	-1.1	1.4	1.0	1.9	1.0	1.2
Number of incorrect matches in round	0.1	0.2	0.5	0.1	0.2	0.7	0.5	0.4	-0.1
Past tobacco smoking	5.6	10.2	14.7	2.6	-2.3	-3.8	-3.8	-3.2	-3.1
Alcohol usually taken with meals	0.3	0.4	1.2	1.1	-0.5	-0.4	-0.7	-0.8	-0.1
Nervous feelings	0.2	0.3	0.9	-0.3	-0.0	-0.8	-0.9	-0.6	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.0	1.1	0.4	1.4	0.3	0.3	-0.9
Hearing difficulty/problems with background noise	2.7	4.3	6.3	-1.9	2.5	1.5	2.1	2.2	2.1
Hair/balding pattern: Pattern 2	0.2	0.3	1.2	0.0	0.2	0.1	0.5	0.3	1.1
Had menopause	0.5	0.6	1.7	1.3	-0.8	-0.2	-0.5	-0.3	-0.9
Had other major operations	0.9	1.1	1.8	1.3	0.0	-1.2	-1.1	-1.1	-0.8
Forced vital capacity (FVC)	1.3	4.9	8.6	-1.5	2.3	2.3	0.9	2.7	2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	5.9	1.2	-2.4	-0.6	-0.9	-0.8	-0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.9	-1.4	0.1	-0.3	0.2	0.2	0.1
Qualifications: None of the above	0.8	1.7	3.7	0.2	0.7	1.9	1.6	1.6	1.0
Financial difficulties in last 2 years	4.5	6.0	10.5	-1.8	0.8	3.2	3.0	2.9	2.0
Mouth/teeth dental problems	0.1	0.1	0.3	0.0	0.5	-0.4	-0.0	-0.1	0.5
Heart attack	0.7	0.9	3.0	-1.7	0.6	0.9	1.2	0.5	-0.1
Allergy	0.8	1.8	2.9	0.5	-1.7	-1.0	-1.7	-1.2	-1.5
Pain all over the body in last month	0.2	0.2	0.8	0.3	0.9	0.1	-0.0	0.0	-0.5
Diabetes (self-reported)	0.8	1.3	2.9	-1.2	0.4	1.5	1.7	0.9	-0.1
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.0	0.8	-1.7	-1.3	-1.3	-1.6	-0.6
Medication: Ramipril	0.5	0.6	1.6	1.1	0.2	-0.0	-0.5	-0.7	-1.3
Medication: Simvastatin	2.0	2.9	6.1	-1.7	1.0	1.7	2.5	1.7	1.4
Fluid intelligence score	0.2	0.5	1.4	-1.0	1.2	0.2	0.7	0.2	0.0
Illnesses of siblings	7.4	10.4	15.4	2.6	-2.4	-3.9	-3.8	-3.5	-2.8
Neuroticism score	1.4	2.8	5.2	-2.3	1.5	1.6	1.3	1.8	1.5
Weight	1.3	6.5	7.8	-2.1	2.2	2.7	2.7	2.8	2.8
Impedance of arm (right)	0.6	2.8	6.3	1.8	-0.7	-1.1	-1.9	-1.5	-2.5
Arm fat percentage (right)	0.1	0.2	1.0	0.2	0.1	0.4	1.0	0.1	-0.3
Trunk fat-free mass	2.4	14.0	22.8	-3.5	3.2	3.5	3.1	4.0	4.8
Hip circumference	1.0	4.4	5.4	-1.8	1.8	2.3	2.2	2.3	2.1
Time employed in main current job	0.5	0.6	1.4	-0.5	1.0	0.4	0.4	0.7	1.2
Alcohol intake versus 10 years previously	0.7	1.0	3.2	0.9	-0.3	1.8	0.6	1.1	0.8
Father’s age at death	7.8	10.5	16.2	2.6	-1.9	-4.0	-4.0	-3.7	-2.6
Worrier / anxious feelings	0.0	0.0	0.1	0.1	-0.1	-0.3	-0.2	-0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.6	8.5	-1.5	1.7	2.6	2.9	2.3	1.3
Falls in the last year	0.2	0.3	0.6	0.7	0.2	-0.1	-0.8	-0.5	-0.6
Hair/balding pattern: Pattern 3	0.4	0.5	0.7	-0.8	0.8	0.7	0.6	0.6	0.7
Number of live births	0.1	0.2	0.6	0.6	-0.8	0.2	0.2	0.0	-0.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	7.7	-0.4	1.1	1.4	0.3	1.9	2.8
Pulse rate	1.4	2.3	6.8	2.6	-0.8	-1.2	-1.4	-1.4	-1.1
Happiness	0.2	0.3	1.0	-0.5	0.4	0.2	0.5	0.3	-1.0
Noisy workplace	1.9	2.4	4.3	-0.8	0.9	2.1	1.6	1.7	1.7
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.0	0.6	0.2	-0.5	-1.0	-0.5	0.1
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.2	5.7	2.4	-1.9	-1.1	-1.7	-1.8	-1.4
Mouth/teeth dental problems: Dentures	0.5	0.8	1.9	-0.8	-0.1	1.4	0.9	1.1	0.2
Asthma	0.1	0.2	0.4	0.5	-0.6	0.0	0.0	-0.0	0.6
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	4.6	-1.0	1.4	2.1	2.1	1.9	1.3
Medication: Cholesterol lowering	0.3	0.4	1.1	-1.0	0.6	-0.1	0.9	0.1	0.6
Depression (self-reported)	0.2	0.2	0.4	-0.3	0.6	0.3	0.5	0.2	0.6
Medication: Lansoprazole	3.5	4.0	6.1	-1.6	0.6	2.5	2.4	2.4	2.0
Prospective memory result	1.0	1.2	2.5	-0.9	0.3	1.2	1.1	1.1	1.6
Lung cancer (father)	0.2	0.2	0.8	0.4	0.3	0.4	0.9	0.1	0.4
Illnesses of mother	0.3	0.4	1.7	0.2	-1.3	-0.4	-0.3	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	7.7	-0.8	1.3	1.4	0.4	2.0	2.8
Pulse wave Arterial Stiffness index	0.9	1.1	2.4	-0.4	0.2	1.5	1.5	1.3	0.4
Impedance of arm (left)	0.8	3.6	6.0	2.0	-1.2	-1.5	-2.2	-1.8	-2.5
Arm fat mass (right)	0.4	1.6	3.5	-0.9	0.9	1.4	1.9	1.3	1.1
Trunk predicted mass	2.3	13.1	21.6	-3.4	3.2	3.4	3.0	3.9	4.7
Standing height	1.5	14.6	20.0	-3.5	3.6	4.1	2.4	4.4	4.5
Length of working week for main job	2.1	2.3	3.9	0.4	1.6	2.0	1.4	1.9	1.5
Exposure to tobacco smoke at home	2.2	2.4	3.7	-1.9	0.8	1.7	1.5	1.7	1.4
Breastfed as a baby	4.6	5.7	12.2	3.5	-1.9	-1.7	-2.6	-2.2	-2.0
Tense / ‘highly strung’	0.4	0.7	1.2	-0.6	-0.0	-0.9	-1.1	-0.7	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	3.4	-1.8	1.8	1.1	1.1	1.2	1.5
Hair/balding pattern: Pattern 4	0.6	1.4	2.7	0.9	-1.7	-0.9	-1.3	-1.2	-1.0
Birth weight of first child	4.1	7.5	13.0	-2.1	2.8	2.4	2.2	3.0	3.6
Peak expiratory flow (PEF)	0.6	1.4	3.7	-0.6	0.0	1.2	0.8	1.5	1.9
Pulse wave reflection index	0.1	0.2	0.5	-0.2	-0.2	-0.3	0.5	-0.1	-0.7
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.6	-1.2	0.5	1.3	1.2	0.9	1.2
Loud music exposure frequency	0.2	0.2	0.6	-0.6	0.7	0.2	-0.1	0.0	0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.7	-0.6	-0.0	-0.1	-0.2	0.1	0.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	0.8	-0.9	-0.6	-0.6	-0.7	-0.4
Blood clot in the leg (DVT)	0.5	0.6	1.7	1.3	-0.5	-0.4	-0.5	-0.7	-0.9
Medication: Paracetamol	0.2	0.4	0.6	0.3	0.6	-0.5	0.3	-0.8	-0.8
Headache pain in last month	0.4	0.7	2.6	-0.9	1.6	0.3	0.3	0.6	0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.0	0.9	-0.2	-0.5	-0.7	-0.5	-1.0
Glaucoma (self-reported)	2.4	2.8	5.5	-1.0	0.7	2.3	2.2	1.8	1.3
Gout (self-reported)	1.7	2.3	5.1	-0.3	-0.1	2.3	1.5	2.0	1.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.6	-0.6	-0.2	0.9	1.6	0.7	-0.1
Medication: Amlodipine	1.2	1.7	3.2	-1.2	0.6	1.1	1.6	1.2	1.8
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	-0.3	-0.2	-0.0	0.1	0.1	0.2
Birth weight	4.6	10.0	13.7	-3.5	3.7	1.8	3.1	3.0	3.5
Chronic bronchitis/emphysema (mother)	1.2	1.3	2.4	-0.2	1.1	1.5	0.8	1.2	1.6
High blood pressure (siblings)	2.1	3.1	5.0	-1.9	1.0	2.1	2.2	1.8	1.3
Forced vital capacity (FVC), Best measure	1.4	5.2	8.6	-1.8	2.4	2.4	0.9	2.7	2.9
Body fat percentage	0.2	0.7	2.2	-0.5	0.5	1.0	1.5	0.7	0.1
Leg fat percentage (right)	0.4	1.6	4.8	-0.8	0.7	1.5	2.2	1.1	0.2
Arm fat-free mass (right)	2.4	12.4	19.8	-3.4	3.1	3.1	3.2	3.7	4.5
Exposure to tobacco smoke outside home	1.0	1.3	2.0	-0.3	1.1	1.4	1.0	1.2	1.4
Comparative body size at age 10	0.0	0.0	0.1	0.2	0.2	-0.0	-0.2	0.1	0.4
Number of full brothers	2.1	2.6	5.3	-2.0	2.3	1.3	1.7	1.2	0.7
Worry too long after embarrassment	1.8	2.9	6.5	-2.6	1.2	1.4	1.2	1.8	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.7	-1.1	1.3	-0.5	-0.2	0.1	0.8
Wheeze or whistling in the chest in last year	2.3	4.0	5.2	-2.3	1.8	1.7	2.1	1.9	2.2
Number of children fathered	0.4	0.4	1.1	0.1	-0.8	1.1	0.3	0.9	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.1	0.6	-0.5	-0.6	-0.4	-0.4
Age at first live birth	0.1	0.1	0.3	-0.0	-0.5	0.1	-0.6	-0.1	0.2
Pulse wave peak to peak time	0.8	0.9	2.2	0.3	0.0	-1.4	-1.5	-1.1	-0.2
Health satisfaction	0.5	0.6	1.4	-1.2	0.8	0.8	1.0	0.4	-0.2
Shortness of breath walking on level ground	1.0	1.2	2.6	-1.1	0.9	1.2	1.6	0.9	0.4
Qualifications: College or University degree	1.1	3.6	7.9	1.1	-0.0	-2.4	-2.8	-2.0	-1.5
Eye problems/disorders: None of the above	0.5	0.5	1.2	0.5	-0.1	-0.9	-1.1	-0.8	-0.3
Mouth/teeth dental problems: Loose teeth	2.0	2.4	4.0	-0.6	2.0	1.8	1.1	1.4	1.9
Emphysema/chronic bronchitis	7.2	8.1	10.7	-2.0	3.0	2.7	2.8	3.1	3.3
Medication for pain relief, constipation, heartburn	0.8	1.3	2.7	0.7	-1.6	-1.2	-1.6	-0.8	-0.3
Neck or shoulder pain in last month	2.5	3.6	7.6	-1.2	0.7	2.8	2.2	2.2	1.5
Medication: Blood pressure	0.6	1.0	1.9	-1.4	0.4	1.1	1.1	0.8	1.1
Angina (self-reported)	0.1	0.1	0.5	-0.1	0.3	0.3	-0.1	-0.1	-0.7
Migraine (self-reported)	0.2	0.3	0.6	0.5	0.8	0.2	-0.4	0.4	0.6
Medication: Ibuprofen	1.8	2.1	3.6	-1.1	1.0	1.9	1.9	1.6	0.9
Medication: Allopurinol	1.5	2.0	5.2	0.1	0.2	2.3	1.8	1.8	0.8
Medication: Omeprazole	0.5	0.5	1.5	-0.4	0.8	1.2	0.8	0.4	-0.5
Medication: Seretide 50 evohaler	1.1	1.2	2.4	-0.6	0.2	1.5	1.2	1.4	1.0
Mean time to correctly identify matches	5.1	9.7	14.4	2.4	-1.2	-3.5	-3.8	-3.7	-3.3
Heart disease (mother)	0.5	0.6	0.9	-0.6	-0.5	1.0	0.8	0.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	3.2	-0.8	0.2	1.4	1.8	1.1	1.1
Whole body fat mass	0.6	2.5	4.3	-1.1	1.2	1.8	2.1	1.6	1.4
Leg fat mass (right)	0.8	3.0	6.3	-1.4	1.2	2.0	2.5	1.7	1.2
Arm predicted mass (right)	2.5	12.8	20.3	-3.5	3.2	3.1	3.2	3.7	4.5
Pulse rate, automated reading	0.2	0.6	2.4	1.5	0.8	0.3	0.3	0.4	0.1
Alcohol intake frequency.	0.2	0.5	2.1	0.8	-1.4	0.5	-0.1	0.1	-0.1
Comparative height size at age 10	1.9	10.6	16.6	-2.6	2.6	4.1	2.2	3.8	3.7
Number of full sisters	5.5	6.7	12.2	-0.9	1.7	3.5	2.8	2.9	2.8
Suffer from ‘nerves’	1.9	3.0	4.3	-1.9	1.9	1.4	1.2	1.8	2.1
Overall health rating	1.8	3.8	5.9	-2.2	2.2	1.7	2.4	1.7	1.2
Chest pain or discomfort	0.5	0.7	1.4	-1.1	1.2	0.7	0.7	0.4	0.7
Had major operations	0.1	0.1	0.3	-0.2	-0.2	0.2	0.4	0.2	0.6
Age at last live birth	0.1	0.1	0.4	-0.1	0.5	0.2	-0.1	0.3	0.6
Family relationship satisfaction	0.2	0.2	0.4	-0.6	0.3	0.5	0.4	0.6	0.1
Leg pain on walking	2.9	3.7	6.3	-2.5	2.2	1.2	1.4	1.5	2.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	-0.8	-0.4	-0.2	0.6	0.1	0.4
Commuting to job workplace: Car/motor vehicle	2.9	3.3	7.0	0.9	-1.4	-1.7	-1.6	-2.1	-2.6
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.7	-0.2	-0.6	-1.6	-1.1	-1.0	-0.8
Medication: Aspirin	0.6	0.8	2.0	-0.1	1.4	1.1	0.9	0.8	0.6
Supplements: Vitamin C	1.4	1.7	4.2	2.0	-1.0	-0.7	-1.5	-0.9	-1.1
Knee pain experienced in last month	3.2	4.9	9.9	-0.8	1.5	2.9	3.1	2.2	1.8
Hypertension (Self-reported)	1.2	3.2	6.7	-2.6	1.4	1.8	1.9	1.6	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.2	-1.1	0.7	0.5	0.7	0.3	0.3
Illnesses of father: Heart disease	0.1	0.1	0.2	0.0	0.4	0.2	0.1	0.3	0.4
Illnesses of siblings: Diabetes	0.5	0.7	1.0	-1.0	0.8	0.6	1.0	0.6	0.8
Smoking status: Previous	5.5	8.2	11.1	-2.5	2.7	3.1	3.3	2.8	2.7
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.8	6.9	-2.6	2.4	1.5	1.7	2.1	2.6
Whole body fat-free mass	2.0	11.6	17.8	-3.2	3.0	3.2	3.0	3.6	4.2
Leg fat-free mass (right)	1.0	5.2	8.5	-2.1	2.2	2.1	1.9	2.4	2.9
Arm fat percentage (left)	0.0	0.2	0.9	0.1	0.0	0.2	0.9	0.0	-0.3
Average weekly red wine intake	0.2	0.3	1.0	-0.0	1.0	0.3	0.7	0.2	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.1	0.6	-0.7	-0.0	-1.0	-0.2	-0.2
Mood swings	1.5	2.7	4.5	-1.4	1.1	2.1	1.6	2.0	1.3
Loneliness, isolation	1.1	1.5	2.6	-1.3	0.8	1.6	0.9	1.6	0.9
Long-standing illness, disability or infirmity	5.9	9.1	13.8	-3.0	2.8	2.9	3.7	2.9	2.7
Ever had bowel cancer screening	6.8	8.0	12.8	-2.7	3.6	2.4	2.8	2.7	2.7
Diabetes diagnosed by doctor	1.3	2.2	4.0	-1.6	0.6	1.9	2.0	1.4	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.8	-0.5	-0.4	0.1	-0.2	-0.6
Friendships satisfaction	0.8	1.0	1.9	-1.2	0.7	0.8	1.4	1.1	0.7
Qualifications: nursing, teaching	3.3	5.2	8.1	1.2	-1.7	-2.8	-2.3	-2.5	-2.6
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.6	-0.1	0.3	0.6	0.5	0.3
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.4	0.5	0.2	-0.1	0.4	0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.1	0.1	0.6	-0.1	0.5	-0.6	-1.1
Medication for cholesterol	4.7	7.1	11.9	3.2	-2.0	-2.4	-3.5	-2.5	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.3	1.5	-1.0	0.2	-0.5	-1.0	-0.8
Back pain experienced in last month	1.0	1.5	3.4	-0.3	1.8	1.5	0.8	1.2	1.1
Mineral and other dietary supplements	0.6	0.8	2.1	0.2	-0.9	-1.1	-1.5	-0.6	0.5
Breast cancer (self-reported)	0.8	1.0	3.2	0.0	-0.2	1.8	1.3	0.8	0.5
Asthma (self-reported)	0.1	0.1	0.5	0.4	-0.7	-0.3	-0.0	-0.2	0.3
Osteoporosis (self-reported)	0.2	0.2	0.4	0.6	0.6	0.3	0.2	0.1	-0.7
Osteoarthritis (self-reported)	3.0	3.9	6.9	-1.1	0.8	2.2	2.5	2.0	2.6
Medication: Aspirin	0.7	0.8	1.8	-0.2	1.3	1.2	1.0	0.8	0.5
Medication: Gliclazide	4.8	5.5	9.7	-2.4	1.1	2.8	3.1	2.5	1.3
Illnesses of father: None of the above (group 1)	0.1	0.2	0.5	0.6	-0.7	0.5	0.1	-0.0	0.1
Smoking status: Current	0.2	0.3	0.6	0.8	-0.5	0.8	0.1	0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	3.3	1.3	-1.0	-1.8	-1.7	-1.2	-0.7
Whole body water mass	2.1	11.7	18.5	-3.2	3.1	3.1	3.0	3.6	4.3
Leg predicted mass (right)	1.0	5.3	8.8	-2.1	2.2	2.1	1.9	2.4	3.0
Arm fat mass (left)	0.4	1.5	3.2	-0.8	0.8	1.2	1.8	1.3	1.2
Number of self-reported non-cancer illnesses	5.5	9.6	11.9	-2.9	3.5	2.9	3.4	2.8	3.0
Average weekly champagne plus white wine intake	0.2	0.3	1.2	0.3	0.4	0.0	-1.1	-0.2	0.4
Miserableness	1.5	2.6	5.1	-2.3	1.5	1.2	1.6	1.5	1.3
Guilty feelings	0.3	0.5	1.3	-1.1	0.7	0.2	0.2	0.5	0.8
Wears glasses or contact lenses	0.2	0.2	0.4	0.4	0.4	0.4	0.6	0.3	0.5
Ever taken oral contraceptive pill	2.0	2.2	3.6	-1.3	-0.2	1.9	1.3	1.9	1.5
Hearing aid user	0.2	0.2	0.4	-0.0	-0.6	-0.6	-0.2	-0.6	-0.2
Mother’s age at death	2.8	3.5	5.3	1.7	-1.0	-2.3	-2.0	-2.3	-1.6
Financial situation satisfaction	1.0	1.3	3.7	-1.0	0.3	1.2	1.9	1.1	0.2
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.2	0.6	-0.7	0.0	-0.3	-0.2	-1.1
Commuting to job workplace: Public transport	2.6	3.1	6.0	-0.6	1.4	1.8	1.4	2.3	2.4
Eye problems/disorders: Glaucoma	2.4	2.8	5.8	-1.3	0.2	2.4	2.0	2.0	1.2
Medication: Blood pressure	2.1	4.0	7.0	-2.6	1.7	2.0	2.1	1.8	1.4
Pain type(s) experienced in last month: Hip pain	1.8	2.3	4.3	-0.5	1.6	2.0	2.1	1.6	0.6
Supplements: Fish oil (including cod liver oil)	1.4	1.8	4.0	-0.9	1.5	1.4	2.0	1.3	0.2
High cholesterol (Self-reported)	0.6	1.0	2.0	-1.1	1.4	0.4	1.3	0.5	0.9
Medication: Bendroflumethiazide	0.5	0.8	3.2	-1.8	0.2	0.4	0.8	0.3	0.6
Medication: Paracetamol	0.2	0.4	1.2	-0.6	1.1	0.0	0.8	-0.1	-0.1
Medication: Lisinopril	0.5	0.6	1.7	-1.3	-0.5	0.6	1.0	0.6	-0.1
Medication: Atorvastatin	2.0	2.4	4.5	1.0	0.0	-1.9	-1.1	-2.1	-2.0
Illnesses of father: High blood pressure	0.7	0.8	3.9	-0.7	2.0	-0.7	0.1	-0.1	0.3
Alcohol drinker status: Never	0.4	0.5	1.7	-0.5	-0.3	0.3	0.7	0.5	1.3
Ever smoked	2.7	4.7	8.5	-0.9	1.1	2.9	2.4	2.3	2.5
Basal metabolic rate	2.0	11.3	16.9	-3.0	3.0	3.3	3.0	3.6	4.1
Leg fat percentage (left)	0.4	1.5	4.0	-0.9	0.7	1.5	2.0	1.2	0.5
Arm fat-free mass (left)	2.3	11.7	17.3	-3.3	3.2	3.1	3.1	3.6	4.2
Number of operations (self-reported)	0.1	0.2	0.6	0.4	0.7	-0.1	-0.2	0.1	0.6
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.2	0.6	-0.9	-0.7	-0.7	-0.4
Irritability	1.9	3.3	5.4	-2.3	1.9	1.3	1.9	1.8	1.5
Risk taking	1.3	1.9	4.5	-0.7	2.1	0.8	1.2	1.5	1.5
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.0	0.7	-0.2	-0.4	-0.8	-0.9	-1.0
Fractured/broken bones in last 5 years	3.6	4.7	7.3	-1.6	1.9	2.7	2.2	2.5	1.8
Age started oral contraceptive pill	0.2	0.3	1.3	0.0	0.0	1.2	0.3	0.6	-0.2
Diastolic blood pressure, automated reading	0.1	0.3	0.9	-0.5	0.2	0.4	0.7	-0.1	-1.0
Ever depressed for a whole week	0.7	0.8	2.6	-1.6	1.0	-0.7	0.5	0.3	0.7
Unable to work because of sickness or disability	1.5	1.9	4.3	-0.9	2.1	1.2	1.4	1.0	1.4
Commuting to job workplace: Cycle	0.2	0.2	0.4	-0.0	0.4	0.4	-0.4	0.6	0.5
Myopia	0.7	1.0	1.6	-0.5	1.1	1.2	1.2	0.9	0.6
Vascular/heart problems diagnosed by doctor	2.5	6.9	13.3	3.6	-2.6	-2.2	-2.9	-2.2	-1.8
Cholesterol lowering medication	1.3	1.9	5.3	-1.2	1.0	1.3	2.3	1.3	0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.7	-0.7	1.0	1.3	1.0	0.7	-0.2
Pain experienced in last month	2.5	4.2	8.4	1.0	-2.9	-2.2	-1.7	-2.1	-1.8
Supplements: Calcium	0.1	0.2	0.4	0.2	-0.1	0.0	0.6	-0.1	-0.7
Basal cell carcinoma (self-reported)	0.5	0.6	2.2	-0.1	0.3	1.5	0.9	0.8	0.1
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.2	-1.8	0.8	1.2	1.4	0.8	0.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.2	1.5	-0.7	-0.4	-0.5	-0.7	-0.7
Heart disease (siblings)	5.1	6.2	8.9	-1.9	3.0	2.9	2.6	2.7	1.6
Alcohol drinker status: Previous	1.0	1.1	1.9	-1.0	0.5	1.4	0.9	1.4	1.0
Pack years of smoking	0.2	0.2	0.6	0.6	-0.4	0.8	-0.1	0.5	0.2
Impedance of whole body	0.5	2.4	4.7	1.4	-0.9	-1.2	-1.9	-1.4	-2.2
Leg fat mass (left)	0.9	3.4	6.1	-1.5	1.3	2.0	2.5	1.9	1.5
Arm predicted mass (left)	2.1	10.7	16.7	-3.2	2.8	3.0	2.9	3.4	4.1