Hub : Genes

RP11-158M2.3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.126	0.0560	3.1e-03	-0.005	NA	-0.005	NA	-0.005	9.4e-01	NA	7.6e-01	NA	8.1e-01
2	GTEx	Brain Cerebellum	0.145	0.0650	8.9e-03	0.022	NA	0.023	NA	0.019	7.4e-02	NA	6.9e-02	NA	8.8e-02
3	GTEx	Brain Cortex	0.257	0.0800	2.9e-04	0.100	NA	0.147	NA	0.138	1.0e-03	NA	7.5e-05	NA	1.2e-04
4	GTEx	Brain Frontal Cortex BA9	0.193	0.0676	7.9e-04	0.109	NA	0.150	NA	0.153	8.2e-04	NA	9.0e-05	NA	7.5e-05
5	GTEx	Cells EBV-transformed lymphocytes	0.171	0.0680	5.5e-03	0.041	NA	-0.002	NA	-0.002	1.8e-02	NA	3.9e-01	NA	3.8e-01
6	GTEx	Testis	0.202	0.0630	2.7e-05	0.216	NA	0.195	NA	0.203	5.7e-10	NA	4.8e-09	NA	2.1e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.7	1.2	4.1	-1.2	1.1	0.2	0.5	2.0	0.3
Bipolar Disorder or Schizophrenia	0.2	0.4	1.2	-0.6	-0.2	-0.9	-0.5	1.1	-0.1
Depressed Affect (Nagel 2018)	0.0	0.1	0.4	-0.3	-0.2	-0.6	-0.1	0.1	-0.0
Depression (Nagel 2018)	0.2	0.3	0.9	-0.0	-0.2	-0.7	0.0	-0.9	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.1	-0.2	-0.4	-0.6	0.6	-0.4
Neuroticism (Nagel 2018)	0.2	0.4	2.0	-0.3	0.3	0.1	0.6	-1.4	-0.2
Schizophrenia (2018)	0.3	0.6	1.5	0.2	-0.9	-1.2	-1.0	-0.2	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	-0.0	-0.3	-0.0	0.7	-0.5	0.4
Worry (Nagel 2018)	0.8	1.6	7.6	1.1	0.7	0.4	0.6	-2.8	0.3
Alzheimer’s Disease (in mother)	2.1	2.5	6.6	0.3	0.8	2.6	1.8	2.0	0.2
Alzheimer’s Disease (in father)	0.4	0.5	0.8	-0.9	-0.8	0.1	-0.5	0.6	-0.9
Alzheimer’s Disease (including proxy)	0.5	0.7	1.2	-0.0	-0.8	0.9	-0.7	1.0	-1.1
Crohns Disease (2017)	0.8	1.7	4.5	-2.1	0.8	-0.1	1.2	1.8	-0.0
Irritable Bowel Disease (IBD)	1.4	3.2	5.0	-1.6	2.1	0.2	1.7	2.1	2.2
Ulcerative Colitis (UC)	1.7	3.2	11.0	-0.3	2.2	0.2	1.3	1.2	3.3
Major Depression (MDD)	0.6	0.7	2.4	0.3	0.6	-1.5	-0.1	-0.0	1.1
Reaction Time	0.6	1.2	4.1	0.3	-2.0	-1.1	-1.1	0.6	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.4	-0.1	0.8	0.3	-0.1	1.2	-0.4
Breast Cancer	1.6	3.9	8.4	2.9	2.5	1.6	1.6	-0.0	1.9
Ovarian Cancer	0.2	0.2	0.4	-0.7	-0.6	0.5	0.6	-0.1	-0.1
Prostate Cancer	1.4	2.0	4.8	0.1	-1.9	-1.4	-1.1	-2.2	-0.6
Age at First Birth	0.3	0.5	1.5	0.7	-0.2	-1.2	-0.6	-0.5	-0.5
Bipolar Disorder (2011)	3.4	3.3	9.7	-2.6	1.4	0.4	1.1	3.1	0.1
Body Mass Index (BMI) (2010)	0.2	0.3	1.0	-0.6	0.4	-0.5	-0.0	-0.1	-1.0
Coronary Artery Disease (CAD)	3.1	3.6	6.3	1.8	-0.6	-1.5	-1.9	-2.5	-2.5
Crohns Disease (2012)	0.6	0.9	1.8	-1.4	1.3	-0.3	0.4	1.3	0.3
Mean Putamen Volume	1.7	1.9	3.8	-1.9	1.1	1.1	1.8	1.4	0.3
Fasting Glucose	1.6	1.9	5.0	-0.7	1.5	1.8	2.2	0.3	0.6
HbA1C	0.6	0.7	2.2	-0.1	0.6	0.8	0.6	1.5	0.8
HDL Cholesterol	1.1	1.8	5.8	-0.2	0.1	1.6	1.0	2.4	1.1
LDL Cholesterol	2.0	3.2	8.3	-0.2	2.9	1.3	2.0	0.8	2.1
Lupus	0.5	0.7	2.7	1.6	-0.5	0.0	-0.6	-1.0	0.2
Neuroticism (2016)	1.0	1.4	3.4	-1.3	1.1	1.0	1.9	0.7	0.8
Primary Biliary Cirrhosis	0.5	0.6	2.7	0.7	0.3	-0.5	-0.1	0.4	1.6
Rheumatoid Arthritis	0.7	1.0	2.9	-1.3	-1.7	0.1	-0.3	-1.1	0.1
Schizophrenia (2014)	0.4	0.8	2.0	-0.3	-0.9	-1.4	-1.0	0.2	-0.9
Triglycerides	0.6	0.9	2.5	0.8	0.6	1.2	0.4	-0.4	-1.6
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.4	1.6	-0.1	-0.2	-0.6	-0.4	-1.5
Ulcerative Colitis	2.3	3.3	7.8	-0.2	2.5	1.3	1.8	0.8	2.8
Blood Eosinophil Count	1.0	7.9	29.3	2.7	1.7	2.4	1.2	-1.1	5.4
Blood Platelet Count	0.7	8.3	22.5	-1.3	3.3	2.1	3.2	0.7	4.7
Blood Red Count	1.7	16.4	36.8	2.1	-4.2	-2.1	-3.1	-5.0	-6.1
Blood White Count	0.6	4.2	10.3	-0.5	-2.1	-2.4	-1.9	-3.2	-1.1
Heel T-Score	0.2	1.8	4.8	-0.6	1.1	2.2	1.6	-1.2	-0.4
BMI	0.1	0.4	1.3	0.1	-0.1	0.5	0.6	-0.6	1.1
Height	2.8	54.8	108.2	-6.4	7.3	6.6	8.4	10.4	3.4
Waist Hip Ratio (WHR)	1.1	4.9	18.7	4.3	0.2	-0.9	-1.4	-2.7	-0.5
Systolic Blood Pressure	2.5	12.6	24.6	1.2	-4.1	-3.6	-3.4	-2.9	-5.0
Smoking Status	1.6	3.8	9.0	-3.0	-1.4	-1.5	-0.1	2.7	1.4
Allergy or Eczema	1.4	3.8	7.8	-1.1	2.5	0.4	2.8	1.5	2.2
Cardiovascular Disease	1.4	4.5	9.5	0.9	-3.1	-2.7	-2.3	-1.5	-1.5
Hypothyroidism (self reported)	2.9	6.6	25.0	2.6	-1.1	-2.0	-1.5	-5.0	-0.6
Respiratory disease	1.2	2.7	9.8	0.7	1.0	1.4	1.6	0.5	3.1
Type 2 Diabetes (T2D) (2018)	0.2	0.5	1.7	-0.1	0.4	1.3	0.7	-0.1	0.6
Lung FEV1/FVC ratio	0.6	3.0	9.2	2.5	1.6	0.3	-0.3	-3.0	-0.0
Lung FVC	0.1	0.4	0.9	-0.9	-1.0	-0.2	-0.1	0.0	0.7
Neuroticism	0.2	0.5	1.6	0.1	0.4	-0.4	0.7	-1.3	0.7
Chronotype (morning person)	0.7	1.7	2.8	-0.4	-1.7	-0.8	-1.7	-1.6	-1.0
Hair Pigment	0.1	4.0	9.5	-3.1	-1.7	-1.4	-0.0	3.0	-0.9
Tanning	0.1	0.9	2.6	-1.6	0.3	-1.2	0.8	0.5	0.6
Hand grip strength (left)	3.1	8.1	20.0	-1.9	2.2	3.5	4.5	1.5	2.3
Number of treatments/medications taken	0.8	1.5	6.9	0.2	0.8	-0.5	0.7	-0.7	2.6
Average weekly spirits intake	0.4	0.5	2.2	-0.1	0.0	0.6	0.6	0.2	1.5
Sensitivity / hurt feelings	1.1	1.9	3.9	-0.2	1.8	2.0	1.9	-0.5	0.5
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.9	0.0	0.4	-0.9	-0.0	-0.6	0.1
Hearing difficulty/problems: Yes	1.6	2.5	6.8	1.9	0.7	-0.1	0.8	-2.6	1.9
Relative age of first facial hair	0.2	0.5	1.3	0.9	-0.2	-0.4	-0.3	-1.1	0.6
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	4.4	1.9	-0.3	-1.5	-1.0	-2.1	0.7
Ever used hormone-replacement therapy (HRT)	2.9	3.7	4.7	-2.2	2.0	1.1	2.2	2.0	1.9
Ever had hysterectomy (womb removed)	0.8	0.9	1.9	-0.1	0.4	1.2	1.2	0.4	1.4
Systolic blood pressure, automated reading	2.1	6.2	12.5	0.4	-3.5	-2.2	-2.4	-1.7	-3.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.9	1.0	0.3	0.7	0.2	-0.8	-0.1
Angina	1.0	1.4	3.0	0.7	-0.3	-1.4	-0.4	-1.7	-1.5
Medication for hormone replacement therapy	1.2	1.3	3.3	-0.3	1.8	-1.0	0.7	0.1	1.7
Vitamin and mineral supplements	1.9	2.6	5.6	0.2	-2.4	-1.9	-2.0	-0.2	-1.5
Supplements: Zinc	0.5	0.6	2.9	-0.1	-1.7	-0.1	-0.2	0.1	-0.7
Medication: Co-codamol	0.3	0.4	0.8	0.2	-0.3	-0.6	-0.7	-0.7	-0.9
Medication: Metformin	0.3	0.4	0.7	-0.2	0.7	0.8	0.7	0.8	-0.2
Diabetes (father)	1.0	1.2	2.7	-0.4	1.7	1.5	1.2	0.8	-0.1
Diabetes (mother)	2.0	2.6	4.5	0.1	1.5	2.1	2.0	0.5	2.1
Severe depression (siblings)	1.9	2.1	3.6	-1.0	1.6	1.9	1.7	1.1	1.1
Pack years adult smoking proportion	0.3	0.4	0.9	0.6	-0.2	-0.5	-0.4	1.0	0.8
Impedance of leg (right)	1.3	6.3	21.6	4.7	-1.4	0.5	-1.2	-3.0	-1.9
Leg fat-free mass (left)	1.6	8.3	17.4	-4.2	2.4	1.6	3.1	3.3	1.9
Trunk fat percentage	0.5	1.9	6.1	2.2	0.2	0.4	-0.4	-2.5	0.6
Hand grip strength (right)	1.2	3.2	8.3	-1.1	1.2	2.7	2.9	0.8	0.8
Townsend deprivation index at recruitment	0.6	0.9	2.2	0.7	0.6	-1.5	-0.9	-0.3	-1.1
Current tobacco smoking	0.6	1.0	2.1	-0.9	-0.5	-1.5	-0.6	1.3	0.9
Average weekly fortified wine intake	1.3	1.5	3.2	0.0	0.5	1.8	1.8	0.4	1.5
Maternal smoking around birth	0.2	0.3	0.7	0.1	-0.5	0.1	-0.8	-0.8	0.4
Fed-up feelings	0.2	0.4	1.3	-0.8	0.2	-0.5	0.3	0.6	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.9	-0.6	-0.1	-0.4	-0.2	-0.2	-0.9
Relative age voice broke	2.3	3.5	7.4	1.8	-2.0	-1.7	-2.7	-1.8	-0.6
Taking other prescription medications	0.8	1.2	5.1	1.2	0.1	-0.3	0.3	-0.8	2.3
Age when periods started (menarche)	0.6	1.5	8.0	-0.7	0.1	0.6	0.3	0.5	2.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	-0.9	-1.0	-0.5	0.0	0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.2	0.2	0.7	0.3	-0.9	0.7	-1.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.2	-0.3	-1.4	-0.3	-1.0	-0.0	-1.5
Qualifications: CSEs or equivalent	0.1	0.1	0.6	-0.7	-0.3	0.0	0.1	0.0	0.1
Serious illness, injury or assault to yourself	0.7	0.8	2.3	-1.5	0.8	-0.5	0.9	0.3	1.0
High blood pressure	1.4	3.8	7.8	0.9	-2.4	-2.8	-2.4	0.1	-1.6
Hayfever, allergic rhinitis or eczema	0.8	1.8	4.5	-0.9	1.3	0.2	2.1	1.2	1.4
Multivitamins +/- minerals	0.6	0.8	1.6	0.1	1.2	1.0	1.3	-0.2	0.8
Stomach or abdominal pain in last month	1.2	1.5	5.3	0.7	0.3	-1.1	-1.3	-2.3	0.2
Supplements: Glucosamine	0.9	1.1	3.3	-0.2	0.7	1.8	1.2	0.5	1.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.0	-0.9	-1.0	-1.2	-1.4	-0.9	0.3
Medication: Atenolol	2.7	3.3	7.3	1.2	-1.0	-2.7	-2.2	-1.7	-1.6
Medication: Levothyroxine sodium	3.2	5.5	11.0	1.7	-1.3	-3.3	-2.5	-2.9	-1.6
Sitting height	1.4	9.6	16.9	-2.6	3.3	2.8	4.1	3.9	0.7
Chronic bronchitis/emphysema (father)	0.9	1.0	3.8	-1.1	-0.3	-0.7	0.3	0.5	2.0
High blood pressure (mother)	1.5	2.1	4.3	1.4	-0.6	-1.4	-1.0	-1.6	-2.1
Body mass index (BMI)	0.1	0.3	1.0	-0.1	0.4	-0.1	0.1	-0.9	1.0
Impedance of leg (left)	1.3	6.4	23.2	4.8	-0.9	0.9	-1.2	-2.6	-2.3
Leg predicted mass (left)	1.5	8.1	16.6	-4.1	2.5	1.6	3.1	3.2	1.9
Trunk fat mass	0.2	1.0	1.6	0.5	1.2	1.2	1.0	-0.7	1.2
Waist circumference	0.2	0.9	3.0	1.7	0.8	0.3	-0.1	-1.1	0.5
Number of incorrect matches in round	0.7	1.2	3.4	-1.8	1.1	-0.6	0.7	1.1	0.9
Past tobacco smoking	2.1	3.8	8.9	3.0	0.8	0.2	-1.2	-1.7	-3.0
Alcohol usually taken with meals	1.3	2.1	6.2	-0.8	1.5	1.4	2.5	0.8	1.1
Nervous feelings	0.6	1.2	2.3	0.1	1.0	1.5	1.0	-0.8	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.5	-0.4	0.6	0.3	-0.5	0.4
Hearing difficulty/problems with background noise	1.8	2.9	6.1	1.8	-0.0	1.6	1.2	-2.5	2.1
Hair/balding pattern: Pattern 2	0.7	0.9	4.5	-0.0	2.1	0.2	0.3	-0.3	0.7
Had menopause	1.2	1.5	2.5	-0.5	1.2	1.6	1.5	1.2	1.1
Had other major operations	0.5	0.6	1.6	-1.3	0.3	-1.0	-0.3	1.0	0.1
Forced vital capacity (FVC)	0.5	1.8	4.6	-2.0	-0.0	0.7	1.2	2.1	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.5	0.5	0.3	-0.5	-1.2	0.5	-0.8
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	3.8	-0.8	0.6	0.7	1.9	0.3	1.5
Qualifications: None of the above	0.4	0.9	2.8	-0.0	-0.8	-0.9	-1.2	-0.1	-1.7
Financial difficulties in last 2 years	0.2	0.3	1.5	-1.2	-0.3	-0.2	-0.3	0.2	0.3
Mouth/teeth dental problems	0.7	1.1	2.6	1.4	0.2	0.1	-0.9	-1.0	-1.6
Heart attack	0.6	0.8	1.5	1.1	0.9	-0.0	-0.2	-1.2	1.1
Allergy	1.3	3.1	9.5	0.3	-1.8	-0.3	-2.3	-0.6	-3.1
Pain all over the body in last month	0.8	0.8	2.6	-0.6	-0.2	-1.2	-0.2	-0.8	-1.6
Diabetes (self-reported)	0.4	0.7	2.0	-1.0	0.6	1.4	0.7	0.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	3.2	0.5	1.8	-0.5	0.3	-1.1	0.9
Medication: Ramipril	0.6	0.8	1.3	0.8	-0.9	-1.1	-1.2	-0.8	-0.5
Medication: Simvastatin	0.2	0.2	0.4	0.3	-0.5	0.4	0.6	-0.5	-0.4
Fluid intelligence score	0.6	1.3	5.7	-0.8	0.4	0.7	0.8	2.4	-0.1
Illnesses of siblings	0.3	0.4	0.7	0.6	-0.3	-0.4	-0.8	-0.7	-0.8
Neuroticism score	0.4	0.8	3.4	0.8	0.6	-0.0	0.3	-1.8	0.6
Weight	0.7	3.6	5.4	-1.8	2.2	1.6	2.3	1.7	1.6
Impedance of arm (right)	1.5	6.9	22.5	4.7	-1.0	-0.6	-2.5	-3.2	-0.8
Arm fat percentage (right)	0.5	1.8	5.5	1.9	0.1	-0.3	-0.9	-2.4	0.9
Trunk fat-free mass	3.1	17.9	30.9	-5.0	4.0	2.9	4.9	5.6	2.1
Hip circumference	0.2	0.8	1.7	-0.1	1.3	1.2	1.0	0.3	0.9
Time employed in main current job	0.8	0.9	4.1	-2.0	0.0	-0.0	1.1	0.4	-0.3
Alcohol intake versus 10 years previously	0.3	0.5	1.6	-0.5	1.2	-0.3	0.6	-0.4	-0.9
Father’s age at death	3.5	4.7	8.6	0.8	2.7	2.7	1.9	0.8	2.9
Worrier / anxious feelings	1.2	2.3	8.2	1.2	1.1	1.5	0.9	-2.9	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.5	-1.0	0.7	0.3	0.7	1.2	-0.4
Falls in the last year	0.3	0.4	0.9	-0.1	0.9	-0.7	-1.0	0.7	-0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.4	-0.8	0.5	-0.5	0.3	0.3
Number of live births	0.4	0.6	1.1	-0.6	0.8	0.8	1.1	0.1	1.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.0	-1.0	0.6	0.9	0.9	0.7	-0.0
Pulse rate	1.9	3.1	6.6	-1.2	1.5	1.4	2.0	2.6	1.6
Happiness	2.9	3.5	8.1	-0.1	1.8	2.8	2.5	0.2	1.8
Noisy workplace	3.5	4.3	8.0	0.3	-1.7	-2.8	-2.4	-2.8	-1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.5	1.2	-0.8	-0.1	-1.0	0.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.7	0.0	0.2	-0.7	-0.4	1.3	0.9
Mouth/teeth dental problems: Dentures	1.7	2.9	10.5	-2.0	0.5	0.3	0.2	3.2	1.6
Asthma	1.4	2.7	10.0	0.9	0.9	0.9	1.9	0.1	3.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.4	-0.0	-0.1	-0.5	-0.4	-0.4
Medication: Cholesterol lowering	0.7	1.0	2.3	1.3	0.7	1.1	0.8	-1.5	-0.3
Depression (self-reported)	0.2	0.2	0.5	-0.4	0.4	0.0	0.4	0.7	0.3
Medication: Lansoprazole	0.3	0.4	1.2	-0.0	-0.7	-1.1	-0.2	0.5	-0.3
Prospective memory result	0.7	0.8	2.3	0.4	-0.3	-0.5	-0.7	-1.3	-1.5
Lung cancer (father)	1.2	1.3	4.3	-1.6	0.9	0.1	0.7	2.1	-0.3
Illnesses of mother	1.0	1.3	2.1	-1.3	1.4	0.6	0.8	1.0	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.9	-1.1	0.8	1.1	1.4	0.8	0.1
Pulse wave Arterial Stiffness index	1.5	1.7	7.3	-1.2	0.1	0.5	0.9	2.7	-0.6
Impedance of arm (left)	1.4	6.3	18.4	4.3	-1.5	-0.7	-2.4	-3.2	-0.9
Arm fat mass (right)	0.2	0.7	1.7	0.2	1.2	0.7	0.7	-0.4	1.3
Trunk predicted mass	3.0	17.2	30.1	-4.9	3.9	2.8	4.8	5.5	1.9
Standing height	2.0	20.1	36.4	-3.9	4.3	4.1	5.5	6.0	1.8
Length of working week for main job	0.7	0.8	2.1	-1.4	0.2	-0.0	-0.1	-0.6	-1.4
Exposure to tobacco smoke at home	1.0	1.1	2.8	-1.6	0.5	0.4	1.7	-0.3	1.0
Breastfed as a baby	0.3	0.4	1.0	-0.7	-0.1	0.4	-0.6	1.0	-0.1
Tense / ‘highly strung’	0.2	0.2	0.5	-0.2	0.5	0.1	0.7	-0.7	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.5	0.2	0.6	0.4	0.9	-0.7	1.6
Hair/balding pattern: Pattern 4	2.6	6.4	15.0	0.0	2.2	3.9	3.7	1.9	0.9
Birth weight of first child	6.0	11.0	35.0	0.4	3.7	2.7	2.6	1.8	5.9
Peak expiratory flow (PEF)	0.8	2.0	4.2	-0.2	1.8	2.0	1.8	0.9	0.5
Pulse wave reflection index	0.4	0.5	1.1	-0.3	-0.3	-0.9	-0.4	0.8	-1.1
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.5	1.6	0.1	0.0	-0.7	-2.1	0.2
Loud music exposure frequency	0.5	0.5	1.6	-1.2	-0.1	-0.5	0.7	0.2	1.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.3	0.5	-0.1	0.5	0.1	1.2	0.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.8	-1.1	0.3	0.9	1.7	0.3	1.5
Blood clot in the leg (DVT)	0.8	1.1	2.8	0.2	1.7	0.8	0.8	0.2	1.5
Medication: Paracetamol	0.1	0.2	0.5	-0.5	0.0	-0.5	-0.4	-0.3	0.7
Headache pain in last month	0.1	0.1	0.5	-0.0	0.3	0.7	0.4	-0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.7	-1.2	0.9	0.5	0.5	1.3	0.4
Glaucoma (self-reported)	0.5	0.6	1.5	1.2	1.2	0.4	-0.1	0.0	0.8
Gout (self-reported)	1.4	1.9	8.2	-2.9	-0.4	1.0	0.5	1.0	-0.7
Hypothyroidism/myxoedema (self-reported)	2.0	3.8	12.9	2.4	-0.3	-1.7	-1.1	-3.6	-0.1
Medication: Amlodipine	0.6	0.8	2.2	0.4	-1.2	-0.0	-0.3	-1.5	-1.1
Medication: Ventolin 100micrograms inhaler	1.6	2.1	3.6	1.9	0.1	1.0	1.9	-1.8	0.9
Birth weight	3.4	7.3	24.6	-1.5	2.5	1.3	2.1	2.3	5.0
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.7	0.7	-0.7	-1.1	-1.3	-0.6	0.0
High blood pressure (siblings)	0.3	0.4	1.9	-0.5	-1.4	-0.4	-0.2	0.2	-0.4
Forced vital capacity (FVC), Best measure	0.5	1.8	4.8	-1.8	0.2	0.8	1.4	2.2	0.6
Body fat percentage	0.5	2.0	6.4	2.2	0.0	0.4	-0.5	-2.5	0.4
Leg fat percentage (right)	0.5	1.8	5.7	2.0	-0.4	0.0	-0.9	-2.4	-0.0
Arm fat-free mass (right)	2.6	13.2	22.5	-4.7	3.0	2.8	4.2	4.4	1.6
Exposure to tobacco smoke outside home	0.2	0.2	0.5	-0.1	-0.0	0.0	0.6	-0.7	-0.7
Comparative body size at age 10	0.4	1.0	2.0	-0.4	1.4	1.1	1.2	0.9	-0.9
Number of full brothers	0.5	0.7	2.5	-0.4	-1.6	0.5	-0.3	0.8	0.6
Worry too long after embarrassment	1.2	2.0	6.3	0.5	0.9	2.5	1.7	-1.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.6	-1.5	1.9	-0.4	0.4	0.4	0.5
Wheeze or whistling in the chest in last year	0.6	1.1	3.8	1.4	0.6	0.3	0.3	-0.1	1.9
Number of children fathered	0.6	0.7	2.7	-1.7	-0.1	-0.3	-0.3	1.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.0	-0.0	0.2	1.0	0.7	-0.7	0.7
Age at first live birth	0.5	0.8	2.0	0.7	-1.4	0.5	0.4	1.4	0.1
Pulse wave peak to peak time	0.9	1.1	5.0	0.8	0.0	-0.3	-0.6	-2.2	0.7
Health satisfaction	0.9	1.1	2.3	-0.7	1.2	0.1	1.3	0.8	1.5
Shortness of breath walking on level ground	0.5	0.6	1.6	-0.3	0.9	-0.0	0.7	-1.2	0.5
Qualifications: College or University degree	0.1	0.4	0.9	0.7	0.9	0.4	0.3	0.9	0.4
Eye problems/disorders: None of the above	1.2	1.3	3.5	-1.9	0.3	1.6	1.2	0.6	-0.3
Mouth/teeth dental problems: Loose teeth	1.9	2.2	7.2	0.8	-2.7	-0.2	-1.5	-1.5	-0.9
Emphysema/chronic bronchitis	0.6	0.7	2.0	0.4	0.1	-0.9	-0.0	-1.4	1.1
Medication for pain relief, constipation, heartburn	0.4	0.6	1.6	0.2	0.5	0.9	1.1	1.3	0.1
Neck or shoulder pain in last month	1.6	2.3	4.8	-2.2	1.0	1.3	1.9	0.3	1.5
Medication: Blood pressure	0.7	1.3	3.2	0.5	-1.8	-1.3	-1.2	-0.2	-1.0
Angina (self-reported)	1.0	1.3	3.2	0.8	-0.1	-1.5	-0.3	-1.8	-1.3
Migraine (self-reported)	0.5	0.6	1.5	-0.6	0.7	1.0	1.2	-0.1	0.7
Medication: Ibuprofen	0.1	0.1	0.5	-0.7	-0.2	0.3	-0.3	-0.1	-0.3
Medication: Allopurinol	0.7	1.0	3.7	-1.9	-0.7	0.8	0.9	-0.3	-0.5
Medication: Omeprazole	1.1	1.3	3.5	-1.9	0.7	-0.5	0.4	0.1	1.9
Medication: Seretide 50 evohaler	1.1	1.3	3.6	-0.5	1.3	0.5	1.9	0.4	1.2
Mean time to correctly identify matches	0.9	1.7	3.4	1.1	-1.9	-1.8	-1.6	0.2	0.4
Heart disease (mother)	5.4	6.5	15.6	3.2	-2.1	-1.0	-2.2	-4.0	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.8	0.1	0.9	0.5	0.3	0.7	0.6
Whole body fat mass	0.2	0.9	1.5	0.5	1.1	1.1	0.9	-0.7	1.2
Leg fat mass (right)	0.1	0.6	1.1	0.2	0.9	1.0	0.8	-0.6	0.8
Arm predicted mass (right)	2.8	14.2	22.5	-4.7	3.0	3.0	4.4	4.7	1.7
Pulse rate, automated reading	0.5	1.5	3.1	-0.7	0.8	1.2	1.3	1.3	1.8
Alcohol intake frequency.	0.2	0.4	1.3	-0.8	-0.3	-1.1	-0.4	-0.7	0.1
Comparative height size at age 10	1.3	7.4	15.7	-2.7	3.0	1.3	4.0	3.1	1.0
Number of full sisters	1.0	1.2	2.6	1.0	-0.8	0.3	-1.4	-1.6	-1.0
Suffer from ‘nerves’	0.3	0.5	0.7	0.9	-0.8	-0.7	-0.8	-0.5	-0.0
Overall health rating	0.9	2.0	4.2	1.7	-0.2	-1.6	-1.6	-2.0	-0.1
Chest pain or discomfort	1.4	2.0	5.8	1.7	-1.3	-1.0	-0.9	-2.4	-0.1
Had major operations	0.8	0.9	1.8	1.1	-0.1	-0.8	-1.3	-0.6	1.2
Age at last live birth	0.7	1.1	2.1	-0.1	-1.4	-1.4	-0.4	1.3	-0.9
Family relationship satisfaction	4.0	4.9	9.7	-2.0	2.0	2.0	2.4	1.5	3.1
Leg pain on walking	0.4	0.5	2.0	0.1	0.5	-0.4	-0.5	-1.4	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	-0.7	0.3	0.4	0.8	-0.2	0.7
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.6	-0.4	-0.1	2.2	1.5	0.8	1.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.3	-0.2	0.0	0.3	-0.4	-0.4
Medication: Aspirin	2.3	3.1	5.6	1.9	-1.0	-1.4	-2.1	-2.4	-1.5
Supplements: Vitamin C	2.1	2.5	4.6	-0.6	1.1	2.1	2.1	0.9	1.9
Knee pain experienced in last month	0.4	0.6	0.9	0.9	-0.5	-0.6	-1.0	-0.8	0.8
Hypertension (Self-reported)	1.5	4.1	7.6	0.7	-2.7	-2.8	-2.5	0.1	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.8	-1.6	-0.4	-1.0	0.5	0.1	1.9
Illnesses of father: Heart disease	1.9	2.7	6.6	1.4	-1.2	-1.9	-1.5	-2.6	0.2
Illnesses of siblings: Diabetes	0.5	0.7	1.6	-0.4	0.9	1.3	1.1	0.0	-0.4
Smoking status: Previous	1.9	2.9	6.4	-2.4	-0.4	0.1	1.5	1.7	2.5
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	10.3	-0.6	1.6	1.8	3.2	1.1	0.9
Whole body fat-free mass	2.6	14.6	23.6	-4.9	3.4	2.6	4.3	4.8	2.0
Leg fat-free mass (right)	1.7	8.9	17.7	-4.2	2.7	1.7	3.1	3.6	1.7
Arm fat percentage (left)	0.5	1.9	6.7	1.8	-0.2	-0.3	-0.9	-2.6	0.8
Average weekly red wine intake	0.3	0.4	0.8	0.4	0.7	0.5	0.9	-0.5	0.9
Handedness (chirality/laterality): Left-handed	0.5	0.5	2.1	1.4	0.3	0.6	0.3	-0.8	0.2
Mood swings	0.6	1.1	2.4	-0.6	1.0	0.8	1.6	0.8	1.4
Loneliness, isolation	0.3	0.5	1.4	0.7	-0.9	1.2	0.0	-0.0	0.4
Long-standing illness, disability or infirmity	0.8	1.2	2.8	1.5	0.2	-0.5	0.1	-1.5	1.7
Ever had bowel cancer screening	0.8	0.9	2.5	1.6	-0.3	-0.1	-0.4	-1.6	0.5
Diabetes diagnosed by doctor	1.2	1.9	4.7	-0.9	1.5	2.2	1.6	1.0	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.7	-0.7	-1.7	-1.3	-1.6	1.1	-0.8
Friendships satisfaction	1.4	1.7	2.8	-1.0	1.7	1.3	1.6	0.5	1.5
Qualifications: nursing, teaching	0.4	0.7	1.5	1.0	-1.0	-0.7	-1.2	-0.6	0.1
Commuting to job workplace: Walk	0.2	0.2	0.8	0.3	-0.7	-0.1	-0.0	0.9	-0.2
Eye problems/disorders: Cataract	0.3	0.3	1.0	0.1	0.8	-0.2	0.3	1.0	0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.8	-0.6	-0.8	-0.9	0.4	-0.6	-0.1
Medication for cholesterol	1.3	2.0	7.1	-0.4	0.9	2.7	1.4	1.3	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.5	1.5	1.1	0.8	0.1	0.2	1.6
Back pain experienced in last month	0.6	0.9	2.7	-1.2	0.7	0.5	0.8	0.2	1.6
Mineral and other dietary supplements	0.6	0.8	1.3	-1.0	-0.3	-1.0	-1.0	0.7	-1.2
Breast cancer (self-reported)	0.7	0.8	3.3	-1.8	-0.4	-1.0	-0.6	-0.2	-0.4
Asthma (self-reported)	1.6	3.1	10.9	0.8	1.2	1.1	2.1	0.3	3.3
Osteoporosis (self-reported)	0.6	0.7	2.7	0.3	1.1	-0.5	0.1	0.3	1.6
Osteoarthritis (self-reported)	0.9	1.2	3.3	0.8	-0.8	-1.8	-1.2	-1.0	0.1
Medication: Aspirin	2.5	3.3	5.4	1.7	-0.7	-1.8	-2.3	-2.2	-1.6
Medication: Gliclazide	0.3	0.3	0.9	-0.6	0.1	0.8	0.9	0.1	0.2
Illnesses of father: None of the above (group 1)	1.2	1.5	3.6	0.0	1.5	1.9	1.4	1.1	0.4
Smoking status: Current	1.0	1.5	3.2	-1.1	-1.4	-1.8	-1.1	1.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.4	1.4	1.3	0.9	0.6	-1.6	0.6
Whole body water mass	2.6	14.6	23.5	-4.8	3.4	2.6	4.3	4.8	2.0
Leg predicted mass (right)	1.8	9.3	17.7	-4.2	2.8	1.8	3.2	3.7	1.8
Arm fat mass (left)	0.2	0.7	1.8	0.0	1.1	0.7	0.9	-0.4	1.3
Number of self-reported non-cancer illnesses	1.2	2.2	8.4	-0.5	0.7	1.1	1.6	0.3	2.9
Average weekly champagne plus white wine intake	0.2	0.3	1.3	0.1	0.5	-0.6	0.2	1.1	0.3
Miserableness	0.1	0.1	0.4	0.2	-0.3	-0.6	-0.1	-0.5	0.0
Guilty feelings	0.8	1.3	3.3	-0.6	-0.8	-1.5	-1.0	-1.8	0.3
Wears glasses or contact lenses	0.9	1.0	4.2	0.7	2.1	0.8	0.8	0.2	0.2
Ever taken oral contraceptive pill	0.7	0.8	2.1	0.7	1.5	-0.0	0.9	0.5	1.0
Hearing aid user	1.0	1.1	3.3	0.2	0.7	-1.7	0.0	-1.8	-0.2
Mother’s age at death	0.2	0.3	0.9	1.0	-0.2	0.1	-0.3	-0.7	-0.3
Financial situation satisfaction	0.5	0.7	3.1	-1.8	-0.8	-0.5	0.1	-0.2	-0.3
Tinnitus: Yes, now most or all of the time	2.5	2.9	4.2	1.4	2.0	1.6	1.8	-1.6	1.7
Commuting to job workplace: Public transport	1.5	1.8	5.8	1.2	0.8	-2.4	-1.8	-0.3	-0.1
Eye problems/disorders: Glaucoma	0.7	0.9	2.1	1.5	1.2	-0.4	-0.9	-0.0	0.9
Medication: Blood pressure	3.5	6.7	12.0	1.9	-2.4	-3.2	-3.5	-1.7	-2.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.5	0.2	-0.4	-0.6	-1.2	-0.7	-0.3
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.8	0.6	0.0	0.2	0.5	-0.6	0.9
High cholesterol (Self-reported)	0.4	0.8	2.6	0.3	-0.9	-0.9	-0.5	-1.6	-0.1
Medication: Bendroflumethiazide	4.2	6.4	11.7	2.2	-2.7	-2.2	-3.4	-2.4	-1.9
Medication: Paracetamol	0.1	0.2	0.4	-0.6	-0.1	-0.4	-0.5	-0.4	0.5
Medication: Lisinopril	0.6	0.8	3.1	-0.6	-1.8	0.4	0.3	-0.2	-1.1
Medication: Atorvastatin	1.6	2.0	4.6	2.1	1.5	1.2	0.5	-1.8	0.7
Illnesses of father: High blood pressure	2.9	3.6	11.3	1.1	-2.2	-0.5	-0.9	-1.7	-3.4
Alcohol drinker status: Never	0.3	0.3	1.3	-1.1	-0.2	-0.5	0.0	0.7	-0.0
Ever smoked	1.6	2.9	8.8	-3.0	-0.6	-0.5	0.7	1.6	2.2
Basal metabolic rate	2.0	11.1	17.0	-4.1	3.2	2.4	3.9	3.9	1.9
Leg fat percentage (left)	0.4	1.6	4.3	2.1	-0.1	0.2	-0.8	-2.1	-0.2
Arm fat-free mass (left)	2.5	12.5	20.3	-4.3	3.3	2.6	4.0	4.5	1.6
Number of operations (self-reported)	0.7	1.1	5.1	-0.7	-0.1	-0.3	0.3	0.9	2.3
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.2	0.1	0.7	0.2	0.8	0.8
Irritability	0.5	0.8	2.6	-1.0	1.0	-1.6	-0.0	-0.5	0.5
Risk taking	0.2	0.3	0.7	-0.8	-0.2	-0.7	-0.0	-0.0	-0.9
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.3	0.5	-1.4	-1.5	-1.5	-0.5	-0.1
Fractured/broken bones in last 5 years	2.1	2.8	11.2	-1.1	0.8	1.2	1.4	0.1	3.3
Age started oral contraceptive pill	1.2	1.6	4.2	-1.2	0.8	1.3	2.0	0.9	0.7
Diastolic blood pressure, automated reading	1.2	3.7	8.2	-1.1	-2.9	-1.8	-1.4	0.4	-2.7
Ever depressed for a whole week	0.7	0.9	2.2	0.3	0.3	0.8	1.4	-0.5	1.5
Unable to work because of sickness or disability	0.4	0.5	1.9	-1.4	-0.3	-0.1	-0.1	0.7	0.8
Commuting to job workplace: Cycle	0.3	0.3	0.9	0.4	0.8	-0.6	0.0	-0.9	-0.0
Myopia	0.2	0.4	0.9	-0.7	0.8	0.2	0.9	0.1	-0.2
Vascular/heart problems diagnosed by doctor	1.8	4.9	10.2	-1.1	2.6	3.2	2.8	0.6	1.7
Cholesterol lowering medication	0.6	0.8	1.5	0.2	-1.2	-1.2	-0.6	-1.1	0.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.5	-1.9	0.2	-1.4	-0.2	-0.1	1.2
Pain experienced in last month	0.5	0.8	1.7	1.3	-0.9	-0.4	-0.7	0.4	-1.3
Supplements: Calcium	2.7	3.0	7.0	-0.6	1.8	1.4	1.8	2.6	1.6
Basal cell carcinoma (self-reported)	1.2	1.4	4.4	2.1	0.6	1.6	0.9	-0.7	-0.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.1	0.9	0.9	-0.1	0.0	-0.9	1.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.2	0.1	1.5	1.0	0.9	0.6	1.3
Heart disease (siblings)	0.4	0.5	1.0	0.7	0.6	-0.7	-0.0	-1.0	0.7
Alcohol drinker status: Previous	1.7	1.9	5.0	1.4	1.2	2.2	1.3	0.1	1.2
Pack years of smoking	0.3	0.4	1.1	0.6	0.2	-0.1	0.2	1.0	1.1
Impedance of whole body	1.3	6.5	22.5	4.7	-1.1	0.2	-1.8	-3.1	-1.5
Leg fat mass (left)	0.2	0.6	1.6	0.1	0.9	1.3	0.9	-0.3	0.7
Arm predicted mass (left)	2.2	11.4	19.8	-4.2	3.1	2.3	3.7	4.5	1.5