Hub : Genes

RP11-21J18.1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.2950 0.1020 0.0049 -0.011 NA -0.006 NA -0.011 0.77 NA 0.500 NA 0.80
2 GTEx Brain Cerebellum 0.3770 0.1250 0.0059 -0.008 NA -0.010 NA -0.006 0.66 NA 0.910 NA 0.52
3 GTEx Muscle Skeletal 0.0732 0.0305 0.0072 0.002 NA 0.018 NA 0.004 0.19 NA 0.006 NA 0.12

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.9 1.4 4.2 -0.2 -2.1 -0.1
Bipolar Disorder or Schizophrenia 1.7 4.1 6.4 2.5 -1.9 1.4
Depressed Affect (Nagel 2018) 0.6 1.3 2.5 0.4 -1.6 1.1
Depression (Nagel 2018) 1.7 2.5 5.0 1.5 -0.4 2.2
Intelligence (Savage-Jansen 2018) 1.9 5.9 11.3 -3.4 1.2 2.2
Neuroticism (Nagel 2018) 0.5 1.2 1.7 -0.6 -1.3 1.2
Schizophrenia (2018) 2.5 5.3 11.5 3.4 -0.8 1.9
Schizophrenia vs Biploar Disorder 2.1 2.8 6.6 1.3 -0.5 2.6
Worry (Nagel 2018) 0.4 0.9 1.9 -1.4 -0.4 0.7
Alzheimer’s Disease (in mother) 0.3 0.4 1.0 -0.4 1.0 0.2
Alzheimer’s Disease (in father) 0.7 0.8 2.2 -0.3 1.5 0.1
Alzheimer’s Disease (including proxy) 1.0 1.4 4.0 -0.5 2.0 -0.3
Crohns Disease (2017) 1.2 2.6 3.0 1.4 1.7 1.7
Irritable Bowel Disease (IBD) 0.7 1.7 3.7 1.9 1.1 0.7
Ulcerative Colitis (UC) 0.4 0.7 1.6 1.3 -0.0 -0.8
Major Depression (MDD) 0.1 0.1 0.3 0.0 -0.6 -0.2
Reaction Time 0.2 0.4 0.6 0.5 0.6 -0.8
Verbal and Numeric Reasoning (VNR) 0.7 1.7 3.5 -1.2 1.9 0.6
Breast Cancer 0.8 2.0 4.9 -2.2 0.4 1.0
Ovarian Cancer 0.8 1.1 2.4 0.8 0.5 -1.5
Prostate Cancer 0.6 0.8 2.4 -0.0 1.5 -0.0
Age at First Birth 1.7 2.4 7.0 2.6 -0.5 -0.3
Bipolar Disorder (2011) 1.5 1.4 2.8 -0.8 -1.7 -0.9
Body Mass Index (BMI) (2010) 1.0 1.3 2.6 -1.6 -0.3 1.1
Coronary Artery Disease (CAD) 0.2 0.2 0.4 0.4 0.7 -0.1
Crohns Disease (2012) 1.2 2.0 3.5 1.9 1.3 0.9
Mean Putamen Volume 1.0 1.2 2.5 1.6 0.9 -0.5
Fasting Glucose 0.1 0.1 0.1 -0.3 0.2 -0.3
HbA1C 1.5 1.7 2.9 -1.7 -0.4 1.4
HDL Cholesterol 0.9 1.6 4.0 0.4 2.0 -0.8
LDL Cholesterol 0.9 1.4 3.3 0.1 1.0 1.8
Lupus 0.8 1.3 2.8 0.9 -0.3 1.7
Neuroticism (2016) 0.6 0.9 2.1 0.8 -1.5 -0.0
Primary Biliary Cirrhosis 0.4 0.6 1.3 -0.6 1.1 0.4
Rheumatoid Arthritis 0.2 0.3 0.4 -0.5 -0.6 -0.6
Schizophrenia (2014) 2.3 5.0 6.3 2.5 -1.7 2.4
Triglycerides 0.3 0.5 0.6 -0.6 -0.8 0.7
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 -0.4 0.5 -0.1
Ulcerative Colitis 0.6 0.9 1.8 1.4 -0.0 -0.9
Blood Eosinophil Count 0.2 1.5 4.5 0.1 -0.1 2.1
Blood Platelet Count 0.6 7.0 16.6 1.3 1.6 -4.1
Blood Red Count 0.3 2.8 5.3 -2.3 1.0 -1.4
Blood White Count 0.1 0.6 1.6 -1.3 -0.4 0.1
Heel T-Score 1.7 13.3 35.8 -6.0 -1.9 0.7
BMI 0.5 2.7 4.5 -1.7 0.8 2.1
Height 0.3 5.2 12.6 3.5 0.4 1.7
Waist Hip Ratio (WHR) 0.2 1.0 1.4 -1.2 -1.1 0.6
Systolic Blood Pressure 0.2 1.0 2.0 -0.9 0.5 -1.4
Smoking Status 3.0 7.2 11.9 -2.5 -3.5 1.9
Allergy or Eczema 0.9 2.3 3.0 1.2 1.7 -1.5
Cardiovascular Disease 0.4 1.4 3.8 -1.9 -0.7 -0.2
Hypothyroidism (self reported) 0.8 1.8 4.9 0.6 -2.2 -0.2
Respiratory disease 4.9 10.9 17.3 3.9 4.2 -0.7
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.4 -0.5 -1.2 -0.0
Lung FEV1/FVC ratio 2.3 11.6 30.0 -0.2 -5.5 2.2
Lung FVC 0.2 1.1 3.2 0.1 -1.8 -0.3
Neuroticism 0.7 1.7 3.4 -0.1 -1.8 1.3
Chronotype (morning person) 0.7 1.7 4.5 0.1 -0.8 -2.1
Hair Pigment 0.0 1.1 2.3 1.5 -0.9 0.4
Tanning 0.1 1.1 3.1 -0.4 1.8 0.4
Hand grip strength (left) 0.1 0.2 0.3 0.5 0.6 -0.2
Number of treatments/medications taken 0.7 1.3 3.3 0.0 1.8 -0.8
Average weekly spirits intake 0.0 0.0 0.0 0.0 -0.0 -0.1
Sensitivity / hurt feelings 0.2 0.4 0.7 -0.5 -0.5 0.9
Frequency of depressed mood in last 2 weeks 0.9 1.2 2.1 0.6 -1.1 1.5
Hearing difficulty/problems: Yes 0.3 0.5 0.7 0.8 0.8 -0.3
Relative age of first facial hair 0.2 0.4 1.1 -1.0 0.2 -0.1
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.9 1.4 0.6 0.6
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.3 -1.5 -0.5 -0.1
Ever had hysterectomy (womb removed) 1.1 1.3 2.2 -0.4 1.5 1.2
Systolic blood pressure, automated reading 0.2 0.6 1.0 -0.6 -1.0 -0.6
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 3.2 -1.8 0.0 0.3
Angina 1.0 1.3 2.0 -1.4 -0.1 1.3
Medication for hormone replacement therapy 0.3 0.4 0.8 -0.0 0.6 0.9
Vitamin and mineral supplements 1.3 1.7 4.3 -0.7 -0.6 -2.1
Supplements: Zinc 0.1 0.2 0.3 -0.2 0.6 0.3
Medication: Co-codamol 0.6 0.6 1.3 -0.8 1.1 0.1
Medication: Metformin 0.5 0.7 0.9 0.5 -0.9 -1.0
Diabetes (father) 0.8 1.0 1.9 -0.6 1.4 0.9
Diabetes (mother) 0.4 0.5 1.5 -0.0 0.2 -1.2
Severe depression (siblings) 1.2 1.3 2.6 1.6 -0.6 -1.0
Pack years adult smoking proportion 1.6 2.5 4.1 -1.6 -0.8 2.0
Impedance of leg (right) 0.1 0.4 0.6 0.6 0.7 -0.5
Leg fat-free mass (left) 0.3 1.3 3.9 -0.1 0.4 2.0
Trunk fat percentage 0.4 1.6 2.7 -1.6 0.3 1.4
Hand grip strength (right) 0.3 0.7 1.8 0.4 0.4 -1.3
Townsend deprivation index at recruitment 2.2 3.1 7.2 -2.7 -1.4 0.5
Current tobacco smoking 3.3 5.4 9.3 -3.0 -2.2 1.5
Average weekly fortified wine intake 1.1 1.3 1.9 1.4 0.7 -1.3
Maternal smoking around birth 1.1 1.7 2.4 -1.5 -1.6 0.6
Fed-up feelings 2.5 4.5 10.6 -0.1 -3.3 1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 1.9 0.9 -1.1 1.4
Relative age voice broke 0.2 0.3 0.5 -0.7 -0.1 -0.6
Taking other prescription medications 0.9 1.4 3.1 -1.8 0.9 -0.6
Age when periods started (menarche) 0.5 1.3 3.5 -0.6 -1.9 0.0
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.3 0.3 0.6 0.1
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 4.4 -2.1 -1.7 1.5
Tinnitus: Yes, but not now, but have in the past 2.3 2.5 5.3 2.3 -0.7 -1.3
Qualifications: CSEs or equivalent 0.5 0.7 1.5 -0.6 -0.3 1.2
Serious illness, injury or assault to yourself 0.3 0.3 0.5 0.7 -0.1 -0.7
High blood pressure 0.4 1.1 1.8 -1.4 -1.2 -0.0
Hayfever, allergic rhinitis or eczema 0.8 1.8 5.3 0.1 2.3 -0.4
Multivitamins +/- minerals 1.3 1.6 4.7 0.3 0.4 2.2
Stomach or abdominal pain in last month 0.9 1.1 1.4 1.2 1.0 -0.9
Supplements: Glucosamine 0.3 0.4 0.6 0.6 -0.3 0.8
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.4 -0.4 -1.1 -1.2
Medication: Atenolol 1.9 2.4 3.8 -1.9 -0.5 1.8
Medication: Levothyroxine sodium 0.5 0.8 1.4 -0.2 -0.9 1.2
Sitting height 0.2 1.6 4.4 2.1 0.1 0.6
Chronic bronchitis/emphysema (father) 1.4 1.7 3.6 1.0 0.6 -1.9
High blood pressure (mother) 0.3 0.4 0.8 0.9 -0.2 -0.6
Body mass index (BMI) 0.8 3.2 5.3 -2.3 -0.2 2.1
Impedance of leg (left) 0.1 0.6 1.0 0.2 1.0 -0.8
Leg predicted mass (left) 0.3 1.4 3.9 0.0 0.5 2.0
Trunk fat mass 0.4 1.7 3.1 -1.4 0.4 1.8
Waist circumference 0.9 3.4 5.2 -2.3 0.2 2.2
Number of incorrect matches in round 0.4 0.6 1.5 1.2 -0.5 0.4
Past tobacco smoking 0.5 0.9 1.8 0.6 1.3 -0.7
Alcohol usually taken with meals 2.1 3.3 6.8 2.6 1.5 -1.0
Nervous feelings 0.5 1.0 1.5 -1.2 -1.0 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.9 0.3 -1.4 0.4
Hearing difficulty/problems with background noise 0.3 0.5 1.0 0.7 -0.0 -1.0
Hair/balding pattern: Pattern 2 1.1 1.4 3.4 -0.8 -1.8 -0.4
Had menopause 0.2 0.3 0.5 -0.5 0.1 -0.7
Had other major operations 0.4 0.5 1.5 0.3 0.1 1.2
Forced vital capacity (FVC) 0.2 0.6 1.3 -0.6 1.2 0.2
Heel bone mineral density (BMD) T-score, automated (right) 2.5 5.7 9.4 -3.1 -2.2 1.8
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.0 0.4 0.9 -1.0
Qualifications: None of the above 2.6 5.5 11.2 -2.3 -3.3 -0.4
Financial difficulties in last 2 years 0.6 0.8 1.0 -0.9 -0.7 1.0
Mouth/teeth dental problems 0.8 1.2 2.1 1.5 -1.2 0.4
Heart attack 0.1 0.1 0.1 -0.3 0.1 0.3
Allergy 2.0 4.7 13.3 -0.9 -3.6 -0.0
Pain all over the body in last month 0.8 0.9 1.7 -1.0 -1.3 0.1
Diabetes (self-reported) 1.4 2.1 4.7 -1.2 -2.2 0.3
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 5.7 0.7 2.4 -0.4
Medication: Ramipril 0.4 0.5 1.3 1.1 0.4 -0.1
Medication: Simvastatin 1.3 1.9 3.0 -1.7 -1.4 0.9
Fluid intelligence score 0.5 1.0 1.3 -0.6 1.2 1.1
Illnesses of siblings 1.1 1.5 2.9 -1.2 1.7 0.5
Neuroticism score 0.5 1.0 1.1 -0.9 -1.1 1.0
Weight 0.5 2.4 6.1 -1.1 0.1 2.5
Impedance of arm (right) 0.3 1.2 2.2 1.5 -0.3 -1.1
Arm fat percentage (right) 0.7 2.9 4.9 -2.2 -0.4 1.9
Trunk fat-free mass 0.2 1.0 2.7 0.4 0.3 1.6
Hip circumference 0.8 3.3 6.4 -1.7 0.8 2.5
Time employed in main current job 0.8 1.0 2.6 -1.6 0.3 -0.5
Alcohol intake versus 10 years previously 0.3 0.5 1.4 0.1 1.2 -0.3
Father’s age at death 0.4 0.5 0.8 -0.8 0.3 0.9
Worrier / anxious feelings 0.2 0.4 0.7 -0.8 0.7 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.6 1.3 0.5 -0.6
Falls in the last year 0.7 1.0 2.7 -0.6 -1.6 -0.2
Hair/balding pattern: Pattern 3 0.2 0.2 0.5 0.7 0.0 0.5
Number of live births 0.5 0.7 1.3 1.1 0.7 0.4
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.1 -0.2 -0.3 0.3
Pulse rate 0.4 0.6 1.2 -0.8 0.2 -1.1
Happiness 0.7 0.8 2.3 -1.5 -0.0 -0.2
Noisy workplace 0.5 0.6 0.8 -0.9 -0.8 0.5
Qualifications: A levels/AS levels or equivalent 1.7 3.8 9.8 3.1 1.2 0.3
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 4.2 2.1 0.6 0.3
Mouth/teeth dental problems: Dentures 1.7 2.9 7.8 -2.8 0.5 -0.8
Asthma 3.8 7.6 17.0 2.4 4.1 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 1.9 1.4 0.0 -1.3
Medication: Cholesterol lowering 0.9 1.3 2.1 -0.9 -1.5 1.0
Depression (self-reported) 4.8 5.8 13.7 -3.7 -1.0 1.6
Medication: Lansoprazole 0.4 0.5 1.2 0.2 0.5 -1.1
Prospective memory result 0.5 0.7 1.2 1.1 -0.9 -0.2
Lung cancer (father) 0.5 0.6 0.8 -0.9 -0.7 -0.6
Illnesses of mother 0.6 0.7 1.1 1.0 -0.7 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.6 0.8 -0.5 0.2
Pulse wave Arterial Stiffness index 0.9 1.0 2.7 -0.6 -0.0 1.6
Impedance of arm (left) 0.2 1.0 1.9 1.4 -0.0 -1.0
Arm fat mass (right) 0.5 1.9 2.9 -1.6 0.3 1.7
Trunk predicted mass 0.2 0.9 2.6 0.4 0.2 1.6
Standing height 0.3 2.8 6.2 2.5 1.1 1.0
Length of working week for main job 1.1 1.2 3.1 -1.8 -0.7 0.3
Exposure to tobacco smoke at home 0.3 0.4 0.7 -0.8 0.7 0.0
Breastfed as a baby 0.1 0.1 0.1 0.3 -0.0 0.3
Tense / ‘highly strung’ 0.1 0.2 0.3 0.0 -0.6 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 3.5 0.2 -0.5 1.9
Hair/balding pattern: Pattern 4 0.6 1.4 2.8 -0.4 1.7 -1.1
Birth weight of first child 1.6 2.9 8.1 0.2 -0.7 2.8
Peak expiratory flow (PEF) 0.0 0.1 0.1 -0.3 0.3 -0.2
Pulse wave reflection index 0.5 0.6 1.1 0.8 0.0 1.1
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.1 -0.3 -0.4 1.1
Loud music exposure frequency 0.8 0.9 1.3 0.4 -1.1 1.1
Qualifications: O levels/GCSEs or equivalent 1.6 2.6 5.6 2.4 0.4 1.4
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 1.2 -1.1 0.9 1.1
Blood clot in the leg (DVT) 0.8 1.1 1.7 0.7 -1.0 1.3
Medication: Paracetamol 0.4 0.7 1.5 1.2 -0.3 -0.7
Headache pain in last month 1.0 1.6 3.7 1.9 0.4 -1.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.4 1.2 0.5 -0.2
Glaucoma (self-reported) 1.9 2.2 3.6 -1.7 1.9 0.3
Gout (self-reported) 0.3 0.4 1.0 1.0 -0.5 0.1
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 6.3 -0.3 -2.5 0.8
Medication: Amlodipine 0.7 1.0 1.7 1.1 -1.3 -0.2
Medication: Ventolin 100micrograms inhaler 1.3 1.6 2.8 1.7 1.2 0.8
Birth weight 0.1 0.3 0.9 1.0 -0.1 0.1
Chronic bronchitis/emphysema (mother) 1.0 1.2 2.6 -1.0 1.6 0.1
High blood pressure (siblings) 1.5 2.1 3.2 1.8 -1.0 -1.5
Forced vital capacity (FVC), Best measure 0.2 0.6 1.0 0.8 1.0 -0.1
Body fat percentage 0.7 2.9 5.3 -2.3 0.3 1.8
Leg fat percentage (right) 1.2 4.3 7.5 -2.7 0.5 2.3
Arm fat-free mass (right) 0.2 1.2 3.1 -0.4 0.6 1.8
Exposure to tobacco smoke outside home 0.8 1.1 1.7 -1.2 1.3 0.5
Comparative body size at age 10 0.4 1.2 1.8 1.3 -0.6 -1.2
Number of full brothers 0.7 0.9 1.7 0.9 -0.2 1.3
Worry too long after embarrassment 0.7 1.1 1.4 -1.2 -0.9 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 0.7 -0.6 -0.8 0.9
Wheeze or whistling in the chest in last year 0.3 0.6 1.7 -0.2 1.3 0.0
Number of children fathered 3.2 3.6 8.6 0.9 2.9 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 2.7 0.9 1.7 -0.7
Age at first live birth 0.7 1.2 2.5 0.9 1.6 -0.5
Pulse wave peak to peak time 0.8 0.9 2.3 0.6 -0.0 -1.5
Health satisfaction 0.4 0.5 1.3 0.0 -0.4 1.1
Shortness of breath walking on level ground 0.9 1.0 2.7 1.7 0.3 0.4
Qualifications: College or University degree 0.8 2.4 6.7 2.6 0.3 -0.6
Eye problems/disorders: None of the above 0.2 0.2 0.5 -0.0 -0.7 0.4
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.7 -0.3 0.6 1.3
Emphysema/chronic bronchitis 0.6 0.7 1.8 -0.5 1.4 0.1
Medication for pain relief, constipation, heartburn 1.1 1.8 2.8 -1.6 0.1 1.7
Neck or shoulder pain in last month 0.2 0.3 0.8 0.9 -0.1 -0.2
Medication: Blood pressure 0.1 0.2 0.4 -0.6 0.5 -0.1
Angina (self-reported) 1.1 1.4 2.2 -1.5 -0.3 1.4
Migraine (self-reported) 3.2 4.0 7.8 2.0 2.8 -0.3
Medication: Ibuprofen 1.9 2.3 3.8 1.9 -0.3 -1.7
Medication: Allopurinol 0.3 0.4 1.2 0.2 -1.1 0.3
Medication: Omeprazole 2.4 2.8 6.4 -1.3 0.6 -2.5
Medication: Seretide 50 evohaler 0.7 0.8 1.4 1.2 -0.6 0.8
Mean time to correctly identify matches 0.1 0.2 0.4 0.1 -0.5 -0.6
Heart disease (mother) 1.3 1.6 2.0 -1.4 -1.0 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 1.9 -1.4 -0.0 0.9
Whole body fat mass 0.7 2.7 4.2 -1.9 0.5 2.1
Leg fat mass (right) 1.0 3.8 6.9 -2.0 0.5 2.6
Arm predicted mass (right) 0.2 1.3 3.4 -0.2 0.5 1.8
Pulse rate, automated reading 0.5 1.8 2.0 -1.2 1.3 -1.4
Alcohol intake frequency. 0.5 1.2 2.0 -0.6 1.1 -1.4
Comparative height size at age 10 0.4 2.2 6.6 2.6 0.2 -0.2
Number of full sisters 0.3 0.3 0.9 -0.9 0.4 0.1
Suffer from ‘nerves’ 2.3 3.6 9.6 -3.1 -0.6 0.9
Overall health rating 0.6 1.2 2.6 -1.6 -1.0 0.1
Chest pain or discomfort 0.5 0.7 1.0 1.0 1.0 -0.3
Had major operations 0.6 0.7 1.2 0.5 0.8 -1.1
Age at last live birth 1.0 1.5 4.0 2.0 0.4 -0.5
Family relationship satisfaction 0.7 0.9 2.6 -1.6 0.0 -0.4
Leg pain on walking 0.2 0.2 0.3 0.2 -0.5 -0.6
Qualifications: NVQ or HND or HNC or equivalent 2.5 3.0 7.1 -1.4 0.0 2.7
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.8 -0.1 0.9 -0.2
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.0 -1.0 -0.2 0.4
Medication: Aspirin 1.0 1.3 2.4 0.9 -0.9 1.5
Supplements: Vitamin C 0.3 0.3 0.7 -0.4 -0.9 0.3
Knee pain experienced in last month 0.1 0.1 0.1 0.3 0.3 0.1
Hypertension (Self-reported) 0.3 0.8 1.3 -1.1 -1.0 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 2.1 -0.4 0.1 -1.5
Illnesses of father: Heart disease 0.1 0.1 0.2 -0.0 -0.5 -0.0
Illnesses of siblings: Diabetes 1.0 1.2 3.4 0.1 -1.8 0.5
Smoking status: Previous 1.1 1.7 3.4 1.2 -1.9 0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.7 5.5 2.3 1.5 0.5
Whole body fat-free mass 0.2 1.1 3.1 0.1 0.3 1.8
Leg fat-free mass (right) 0.2 1.1 3.1 -0.1 0.5 1.8
Arm fat percentage (left) 0.7 2.8 4.9 -2.2 -0.2 1.8
Average weekly red wine intake 1.1 1.6 4.8 2.2 0.2 0.3
Handedness (chirality/laterality): Left-handed 2.4 2.9 4.8 -0.4 1.9 -2.2
Mood swings 0.8 1.5 3.5 0.3 -1.9 1.0
Loneliness, isolation 0.3 0.4 1.1 1.1 -0.2 -0.1
Long-standing illness, disability or infirmity 0.3 0.4 0.5 0.6 -0.6 0.7
Ever had bowel cancer screening 1.1 1.3 3.3 0.8 -0.2 -1.8
Diabetes diagnosed by doctor 0.9 1.4 4.2 -0.1 -2.0 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 2.1 2.3 3.5 -0.4 -1.9 1.8
Friendships satisfaction 0.2 0.3 0.4 -0.6 0.6 -0.3
Qualifications: nursing, teaching 1.8 2.8 5.7 1.6 2.4 0.6
Commuting to job workplace: Walk 1.1 1.1 1.7 -1.3 -1.2 -0.6
Eye problems/disorders: Cataract 0.4 0.4 1.2 1.1 0.1 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 0.8 0.3 0.9 -0.9
Medication for cholesterol 0.5 0.8 1.4 -0.4 1.2 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.4 -1.2 0.3 -0.7
Back pain experienced in last month 0.2 0.3 0.5 0.7 -0.6 -0.2
Mineral and other dietary supplements 0.2 0.3 0.7 -0.8 -0.1 -0.4
Breast cancer (self-reported) 0.1 0.1 0.2 0.3 -0.5 0.3
Asthma (self-reported) 3.6 7.2 16.3 2.3 4.0 -0.1
Osteoporosis (self-reported) 4.1 5.1 9.3 3.1 -2.0 -1.3
Osteoarthritis (self-reported) 0.5 0.7 1.0 -1.0 0.9 0.5
Medication: Aspirin 1.0 1.2 2.9 0.5 -0.7 1.7
Medication: Gliclazide 1.3 1.4 2.4 1.3 -1.6 0.5
Illnesses of father: None of the above (group 1) 0.8 1.0 2.3 -0.7 -0.4 1.5
Smoking status: Current 2.8 4.4 8.6 -2.9 -1.6 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.6 -0.4 -0.8 0.4
Whole body water mass 0.2 1.2 3.4 0.1 0.3 1.8
Leg predicted mass (right) 0.2 1.2 3.3 0.0 0.5 1.8
Arm fat mass (left) 0.6 2.5 4.4 -1.7 0.4 2.1
Number of self-reported non-cancer illnesses 0.5 0.9 1.2 -1.1 1.1 0.5
Average weekly champagne plus white wine intake 1.6 2.1 4.1 2.0 1.2 0.9
Miserableness 0.6 1.1 2.8 -0.1 -0.7 1.7
Guilty feelings 0.6 0.9 1.6 1.0 -0.0 1.3
Wears glasses or contact lenses 0.3 0.3 0.8 0.4 -0.9 -0.0
Ever taken oral contraceptive pill 0.2 0.2 0.4 -0.6 0.4 0.1
Hearing aid user 0.5 0.5 1.2 0.4 1.1 0.5
Mother’s age at death 0.1 0.1 0.2 0.5 -0.0 -0.1
Financial situation satisfaction 2.9 3.6 7.0 -2.7 -0.8 -1.8
Tinnitus: Yes, now most or all of the time 0.5 0.5 1.6 1.3 0.0 0.1
Commuting to job workplace: Public transport 0.4 0.5 1.0 1.0 -0.7 -0.1
Eye problems/disorders: Glaucoma 0.6 0.7 1.1 -0.9 1.1 0.2
Medication: Blood pressure 0.6 1.1 3.1 -0.2 -1.8 -0.2
Pain type(s) experienced in last month: Hip pain 1.7 2.2 5.7 0.6 -0.7 -2.4
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.5 -0.5 0.6 0.7
High cholesterol (Self-reported) 0.4 0.8 1.4 0.6 -1.2 0.8
Medication: Bendroflumethiazide 0.4 0.6 1.7 0.0 -0.1 1.3
Medication: Paracetamol 0.8 1.3 3.3 1.8 -0.2 -0.7
Medication: Lisinopril 2.4 3.1 4.3 -1.3 -2.1 1.9
Medication: Atorvastatin 0.2 0.3 0.7 -0.1 -0.2 0.8
Illnesses of father: High blood pressure 0.2 0.3 0.6 0.3 -0.8 -0.4
Alcohol drinker status: Never 0.1 0.2 0.3 -0.1 0.6 -0.4
Ever smoked 0.6 1.1 1.3 -1.1 -0.9 1.2
Basal metabolic rate 0.3 1.5 4.2 -0.2 0.5 2.1
Leg fat percentage (left) 1.3 4.6 8.9 -3.0 0.6 2.1
Arm fat-free mass (left) 0.2 1.1 3.0 -0.4 0.5 1.7
Number of operations (self-reported) 0.5 0.7 1.1 -0.7 -0.7 1.0
Average weekly beer plus cider intake 0.6 0.9 1.9 -0.8 0.5 1.4
Irritability 2.5 4.3 6.1 -2.4 -1.1 2.5
Risk taking 1.1 1.6 4.2 0.6 -0.5 2.1
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.5 -0.4 -0.1 -1.2
Fractured/broken bones in last 5 years 1.2 1.5 3.9 0.7 0.3 2.0
Age started oral contraceptive pill 0.6 0.7 1.6 0.3 -1.3 0.6
Diastolic blood pressure, automated reading 0.4 1.3 2.6 -1.6 -0.2 -1.1
Ever depressed for a whole week 0.2 0.2 0.3 0.5 0.6 -0.4
Unable to work because of sickness or disability 0.1 0.1 0.3 -0.1 -0.3 0.5
Commuting to job workplace: Cycle 2.2 2.7 3.8 0.7 2.0 -1.9
Myopia 1.2 1.8 4.1 2.0 0.3 -1.1
Vascular/heart problems diagnosed by doctor 0.5 1.4 3.1 1.8 0.9 0.2
Cholesterol lowering medication 0.2 0.3 0.4 0.4 -0.6 0.6
Medication: Omeprazole (e.g. Zanprol) 2.1 2.6 5.4 -1.5 0.2 -2.3
Pain experienced in last month 0.6 1.0 1.7 -1.3 0.8 0.7
Supplements: Calcium 1.2 1.3 3.5 1.9 0.4 -0.6
Basal cell carcinoma (self-reported) 1.6 1.9 2.2 -1.5 -1.2 1.5
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 -0.1 -0.2 0.6
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.5 0.6 -0.7 1.2
Heart disease (siblings) 4.5 5.6 13.8 1.2 -3.7 1.2
Alcohol drinker status: Previous 0.4 0.5 1.1 0.5 1.0 -0.4
Pack years of smoking 1.8 2.6 3.9 -1.6 -1.2 2.0
Impedance of whole body 0.1 0.6 1.0 0.8 0.4 -1.0
Leg fat mass (left) 1.0 3.8 6.2 -2.1 0.8 2.5
Arm predicted mass (left) 0.2 1.1 2.5 -0.5 0.6 1.6