Hub : Genes

RP11-22P6.2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.152	0.088	0.0019	0.082	NA	0.038	NA	0.044	0.0021	NA	0.028	NA	0.019
2	GTEx	Esophagus Gastroesophageal Junction	0.159	0.072	0.0013	0.027	NA	0.014	NA	0.007	0.0370	NA	0.096	NA	0.170
3	GTEx	Ovary	0.099	0.049	0.0035	0.017	NA	0.061	NA	0.056	0.1200	NA	0.013	NA	0.017

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	3.2	5.1	8.4	-1.3	-2.3	-2.9
Bipolar Disorder or Schizophrenia	1.5	3.7	5.8	-1.5	-1.8	-2.4
Depressed Affect (Nagel 2018)	2.9	6.0	9.7	-1.6	-2.4	-3.1
Depression (Nagel 2018)	0.6	0.9	1.3	-0.8	-1.2	-0.9
Intelligence (Savage-Jansen 2018)	21.6	66.3	102.0	6.2	7.7	10.1
Neuroticism (Nagel 2018)	1.1	2.7	5.3	-0.4	-1.6	-2.3
Schizophrenia (2018)	0.2	0.4	0.6	-0.8	-0.3	-0.7
Schizophrenia vs Biploar Disorder	0.6	0.8	2.4	0.2	0.0	1.5
Worry (Nagel 2018)	1.3	2.6	4.8	-0.2	-2.2	-1.8
Alzheimer’s Disease (in mother)	1.8	2.2	3.4	-0.0	1.8	1.9
Alzheimer’s Disease (in father)	0.4	0.4	0.7	0.6	-0.3	0.8
Alzheimer’s Disease (including proxy)	2.0	2.9	5.3	0.6	1.8	2.3
Crohns Disease (2017)	15.1	33.0	44.4	-4.7	-5.7	-6.7
Irritable Bowel Disease (IBD)	16.6	39.5	53.1	-4.8	-6.5	-7.3
Ulcerative Colitis (UC)	8.7	16.4	23.6	-2.3	-4.5	-4.9
Major Depression (MDD)	0.2	0.2	0.5	-0.0	0.4	0.7
Reaction Time	0.6	1.1	3.3	1.8	-0.3	0.0
Verbal and Numeric Reasoning (VNR)	12.9	31.0	52.1	4.5	4.5	7.2
Breast Cancer	0.6	1.4	3.4	-0.5	1.8	0.8
Ovarian Cancer	0.4	0.6	1.0	0.7	1.0	0.6
Prostate Cancer	0.2	0.2	0.5	0.7	-0.3	-0.2
Age at First Birth	0.1	0.1	0.3	0.0	-0.2	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	21.9	30.0	44.4	-5.0	-4.5	-6.7
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	16.2	26.1	31.1	-5.0	-4.7	-5.6
Mean Putamen Volume	4.1	4.6	5.9	1.9	2.1	2.4
Fasting Glucose	0.4	0.5	1.0	-0.4	-0.6	-1.0
HbA1C	1.7	1.9	3.5	-1.2	-0.9	-1.9
HDL Cholesterol	4.7	7.9	14.3	1.7	2.5	3.8
LDL Cholesterol	1.1	1.8	3.0	1.7	-1.2	1.0
Lupus	1.2	1.9	4.7	-2.2	1.0	-0.1
Neuroticism (2016)	1.8	2.7	4.5	-0.1	-2.1	-1.9
Primary Biliary Cirrhosis	0.6	0.8	2.4	-0.1	-0.1	1.5
Rheumatoid Arthritis	5.0	6.8	10.3	-3.2	0.0	-3.2
Schizophrenia (2014)	0.9	1.9	3.1	-0.8	-1.4	-1.8
Triglycerides	0.7	1.1	2.6	0.1	-1.6	-0.9
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	3.9	5.6	9.0	-1.9	-2.0	-3.0
Blood Eosinophil Count	0.5	3.7	6.7	-2.1	-0.3	-2.6
Blood Platelet Count	1.4	16.3	22.8	2.6	-4.8	-4.4
Blood Red Count	6.2	60.3	93.5	6.3	6.9	9.7
Blood White Count	0.7	5.4	14.7	-1.2	-0.3	-3.8
Heel T-Score	0.7	5.6	7.5	2.3	2.7	1.9
BMI	21.5	124.5	163.8	-10.8	-9.6	-12.8
Height	0.9	16.6	23.7	-4.9	-4.1	-3.0
Waist Hip Ratio (WHR)	0.4	1.8	3.9	-2.0	-0.5	-1.0
Systolic Blood Pressure	0.2	0.9	1.7	-0.3	-1.3	0.9
Smoking Status	0.6	1.4	3.9	-0.2	2.0	0.6
Allergy or Eczema	5.5	14.4	22.9	4.8	2.4	3.8
Cardiovascular Disease	3.6	12.0	14.4	-3.7	-2.8	-3.8
Hypothyroidism (self reported)	3.1	7.1	11.2	-2.4	-2.0	-3.3
Respiratory disease	0.5	1.1	2.9	1.7	0.3	0.5
Type 2 Diabetes (T2D) (2018)	4.0	7.6	13.4	-2.7	-1.3	-3.7
Lung FEV1/FVC ratio	0.2	1.3	1.8	1.1	0.9	1.4
Lung FVC	4.1	20.9	36.4	2.6	4.4	6.0
Neuroticism	0.3	0.8	1.3	0.2	-1.1	-1.1
Chronotype (morning person)	1.9	4.5	6.6	-1.0	-2.6	-2.4
Hair Pigment	0.0	1.3	3.0	1.7	1.0	0.2
Tanning	0.2	2.5	6.2	1.0	0.6	2.5
Hand grip strength (left)	1.5	4.1	8.5	1.0	1.7	2.9
Number of treatments/medications taken	1.7	3.0	6.1	-1.6	-0.7	-2.5
Average weekly spirits intake	0.2	0.3	0.5	0.5	0.7	0.5
Sensitivity / hurt feelings	0.2	0.4	0.7	-0.6	-0.4	-0.8
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.2	-0.1	-1.1	-0.4
Hearing difficulty/problems: Yes	0.3	0.5	1.3	-0.1	1.1	-0.4
Relative age of first facial hair	0.6	1.2	2.2	0.9	1.5	0.7
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.2	0.1	0.1
Ever used hormone-replacement therapy (HRT)	1.4	1.8	2.4	1.3	1.5	1.1
Ever had hysterectomy (womb removed)	0.8	0.9	2.6	1.6	0.0	-0.3
Systolic blood pressure, automated reading	1.3	3.9	4.9	-2.2	-1.9	-1.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.5	-0.0	1.6	-0.3
Angina	0.8	1.0	1.6	1.2	0.2	1.2
Medication for hormone replacement therapy	1.0	1.1	2.0	1.0	1.4	0.3
Vitamin and mineral supplements	0.5	0.7	1.2	0.1	-1.1	-0.9
Supplements: Zinc	0.7	0.8	1.5	0.9	1.2	0.3
Medication: Co-codamol	6.1	7.1	8.5	-2.2	-2.8	-2.9
Medication: Metformin	6.3	8.9	12.0	-2.4	-3.0	-3.5
Diabetes (father)	1.0	1.2	2.2	-0.6	-1.1	-1.5
Diabetes (mother)	0.5	0.6	1.1	-0.6	-0.6	-1.0
Severe depression (siblings)	0.2	0.2	0.5	0.1	0.7	-0.1
Pack years adult smoking proportion	9.6	14.6	21.0	-2.2	-4.6	-4.2
Impedance of leg (right)	5.3	25.5	31.9	5.1	4.3	5.7
Leg fat-free mass (left)	15.9	84.3	100.0	-8.8	-8.6	-10.0
Trunk fat percentage	33.4	133.9	174.2	-11.3	-10.0	-13.2
Hand grip strength (right)	5.4	14.7	25.2	3.2	2.9	5.0
Townsend deprivation index at recruitment	0.3	0.4	1.0	-0.4	-0.1	-1.0
Current tobacco smoking	1.9	3.2	7.6	-1.3	-0.6	-2.8
Average weekly fortified wine intake	0.0	0.0	0.1	0.2	-0.2	-0.0
Maternal smoking around birth	0.4	0.6	1.0	0.9	1.0	-0.1
Fed-up feelings	5.0	9.2	15.6	-2.3	-2.6	-3.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.3	3.0	-1.7	-1.4	-1.5
Relative age voice broke	0.8	1.2	1.4	1.2	1.0	1.1
Taking other prescription medications	0.2	0.3	0.9	-0.3	0.1	-0.9
Age when periods started (menarche)	3.7	8.8	11.2	2.5	3.3	3.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.0	0.0	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.4	-1.2	-0.3	-1.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.0	-0.0	-0.4	-1.0
Qualifications: CSEs or equivalent	3.8	5.1	6.1	-1.8	-2.5	-2.4
Serious illness, injury or assault to yourself	0.2	0.2	0.3	0.4	0.5	0.5
High blood pressure	2.8	7.8	11.7	-3.4	-2.5	-2.3
Hayfever, allergic rhinitis or eczema	3.8	8.3	13.2	3.6	1.9	2.9
Multivitamins +/- minerals	2.6	3.2	4.3	1.2	2.1	2.0
Stomach or abdominal pain in last month	1.4	1.7	2.9	1.7	0.8	1.2
Supplements: Glucosamine	0.0	0.0	0.1	-0.2	0.0	-0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.2	-0.0	-1.1	-0.4
Medication: Atenolol	0.5	0.7	1.1	-1.0	-0.8	-0.5
Medication: Levothyroxine sodium	1.0	1.6	2.8	-1.0	-1.1	-1.7
Sitting height	0.1	0.6	0.9	-1.0	0.3	0.9
Chronic bronchitis/emphysema (father)	0.5	0.6	1.2	-0.7	0.3	-1.1
High blood pressure (mother)	1.1	1.5	2.9	-0.2	-1.2	-1.7
Body mass index (BMI)	20.8	88.4	113.7	-9.2	-8.2	-10.7
Impedance of leg (left)	4.9	23.7	31.4	4.6	4.3	5.6
Leg predicted mass (left)	16.2	85.8	102.0	-8.9	-8.7	-10.1
Trunk fat mass	32.9	141.2	174.2	-11.8	-10.5	-13.2
Waist circumference	32.5	119.0	146.4	-10.7	-9.8	-12.1
Number of incorrect matches in round	0.9	1.4	4.2	0.3	2.0	0.2
Past tobacco smoking	2.9	5.3	7.5	-1.3	-2.7	-2.6
Alcohol usually taken with meals	5.3	8.6	13.5	2.6	2.4	3.7
Nervous feelings	3.5	6.6	9.9	-0.1	-3.1	-3.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.8	1.7	-0.2	0.3
Hearing difficulty/problems with background noise	3.2	5.2	9.0	1.5	3.0	2.0
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	-0.2	-0.8	-0.4
Had menopause	0.6	0.8	1.5	-0.5	-0.8	-1.2
Had other major operations	1.5	1.8	3.9	-0.8	-1.0	-2.0
Forced vital capacity (FVC)	0.6	2.3	3.0	-1.3	1.5	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	-0.6	0.2	-1.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.1	-0.4	0.5
Qualifications: None of the above	9.2	19.6	31.6	-3.9	-3.5	-5.6
Financial difficulties in last 2 years	0.1	0.2	0.4	-0.7	-0.1	0.3
Mouth/teeth dental problems	1.2	1.8	3.0	1.7	-0.8	1.4
Heart attack	1.6	2.1	4.6	-2.1	-0.9	-0.9
Allergy	1.8	4.2	8.0	-2.8	-1.2	-1.8
Pain all over the body in last month	1.0	1.0	2.1	-0.8	1.4	0.6
Diabetes (self-reported)	4.2	6.4	10.3	-2.4	-1.7	-3.2
Hayfever/allergic rhinitis (self-reported)	3.2	4.2	8.6	2.9	1.2	1.6
Medication: Ramipril	2.1	2.7	3.1	-1.8	-1.6	-1.6
Medication: Simvastatin	0.7	1.1	1.4	-1.0	0.9	-1.2
Fluid intelligence score	11.1	23.0	39.4	3.5	4.2	6.3
Illnesses of siblings	1.3	1.8	3.3	1.3	-0.7	1.8
Neuroticism score	0.9	1.8	2.7	-0.5	-1.6	-1.6
Weight	24.1	118.3	141.6	-10.9	-9.7	-11.9
Impedance of arm (right)	1.1	4.9	8.1	-1.5	-2.1	-2.8
Arm fat percentage (right)	32.5	128.2	163.8	-11.1	-9.9	-12.8
Trunk fat-free mass	3.5	20.3	22.3	-4.7	-4.5	-4.2
Hip circumference	31.0	133.4	166.4	-11.3	-10.3	-12.9
Time employed in main current job	0.1	0.1	0.4	0.1	-0.6	-0.0
Alcohol intake versus 10 years previously	1.4	2.0	4.5	-1.2	-0.4	-2.1
Father’s age at death	0.6	0.8	1.7	1.3	0.4	0.8
Worrier / anxious feelings	0.9	1.6	3.7	0.2	-1.9	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	3.9	-1.9	-1.1	-2.0
Falls in the last year	0.3	0.4	0.7	0.1	0.8	0.8
Hair/balding pattern: Pattern 3	1.2	1.8	4.4	0.6	2.1	0.8
Number of live births	2.9	4.2	9.4	3.1	0.8	1.6
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	6.7	-0.5	2.1	2.6
Pulse rate	0.9	1.5	3.8	1.9	-0.7	0.5
Happiness	3.8	4.6	7.8	1.7	1.8	2.8
Noisy workplace	0.8	0.9	2.6	-0.4	1.6	-0.2
Qualifications: A levels/AS levels or equivalent	4.2	9.4	13.8	2.3	3.0	3.7
Serious illness, injury or assault of a close relative in last 2 years	6.9	8.0	12.4	2.1	2.7	3.5
Mouth/teeth dental problems: Dentures	0.9	1.6	3.3	-1.8	0.8	-0.9
Asthma	0.3	0.6	1.6	1.2	0.0	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	0.5	-0.5	-0.9
Medication: Cholesterol lowering	0.5	0.8	1.5	-1.2	0.9	-0.5
Depression (self-reported)	0.2	0.2	0.5	-0.2	-0.7	-0.2
Medication: Lansoprazole	0.3	0.4	0.5	-0.4	-0.6	-0.7
Prospective memory result	0.4	0.5	1.4	-1.2	-0.3	-0.4
Lung cancer (father)	1.7	1.9	2.9	-1.7	-1.6	-0.6
Illnesses of mother	0.2	0.3	0.6	-0.8	0.4	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	5.4	-0.2	2.3	2.3
Pulse wave Arterial Stiffness index	5.0	5.8	7.0	2.6	2.3	2.3
Impedance of arm (left)	1.1	5.2	8.1	-1.7	-2.1	-2.9
Arm fat mass (right)	30.2	124.3	156.2	-10.8	-10.0	-12.5
Trunk predicted mass	3.5	20.3	22.2	-4.7	-4.5	-4.2
Standing height	1.9	18.8	21.8	-4.7	-4.5	-3.9
Length of working week for main job	0.2	0.2	0.3	-0.6	-0.5	-0.0
Exposure to tobacco smoke at home	0.9	1.0	1.6	0.1	-1.3	-1.2
Breastfed as a baby	6.4	8.0	11.0	1.7	3.3	3.2
Tense / ‘highly strung’	0.5	0.9	2.0	0.2	0.8	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.4	0.5	-0.6	0.3
Hair/balding pattern: Pattern 4	1.6	3.8	5.1	2.1	1.4	2.2
Birth weight of first child	4.1	7.4	11.4	-2.6	-2.0	-3.4
Peak expiratory flow (PEF)	0.9	2.0	5.1	-2.3	1.0	0.2
Pulse wave reflection index	4.0	4.9	9.3	1.6	3.0	1.8
Ever highly irritable/argumentative for 2 days	0.5	0.7	1.7	-1.3	-0.5	0.1
Loud music exposure frequency	0.9	1.0	1.9	-0.7	1.4	0.7
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	4.4	1.2	0.5	2.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.2	-1.5	0.1	-1.4
Blood clot in the leg (DVT)	0.7	0.9	2.5	1.6	0.2	0.1
Medication: Paracetamol	5.2	8.7	13.4	-1.6	-3.2	-3.7
Headache pain in last month	1.3	2.2	3.6	-1.5	-0.9	-1.9
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	2.7	1.6	0.7	1.5
Glaucoma (self-reported)	0.2	0.3	0.8	0.9	0.2	0.2
Gout (self-reported)	1.0	1.4	3.5	-1.9	0.2	-0.9
Hypothyroidism/myxoedema (self-reported)	1.6	3.1	4.7	-1.5	-1.5	-2.2
Medication: Amlodipine	2.3	3.2	3.9	-2.0	-1.9	-1.4
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.4	-0.6	-1.2	-0.6
Birth weight	3.3	7.1	10.3	-2.5	-2.2	-3.2
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.6	0.8	-1.3	0.1
High blood pressure (siblings)	0.9	1.3	2.3	-0.5	1.1	-1.5
Forced vital capacity (FVC), Best measure	0.4	1.5	2.0	-0.9	1.4	1.4
Body fat percentage	29.8	117.5	151.3	-10.7	-9.3	-12.3
Leg fat percentage (right)	15.7	56.8	74.0	-7.5	-6.4	-8.6
Arm fat-free mass (right)	5.4	27.7	31.2	-5.6	-5.0	-5.2
Exposure to tobacco smoke outside home	0.7	0.9	1.9	-1.4	0.9	-0.3
Comparative body size at age 10	16.4	45.3	61.0	-6.0	-6.3	-7.8
Number of full brothers	0.5	0.7	1.1	1.1	0.9	0.3
Worry too long after embarrassment	1.3	2.2	5.6	2.4	0.9	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.7	0.8	-0.2	0.8
Wheeze or whistling in the chest in last year	2.5	4.4	6.7	-1.4	-2.1	-2.6
Number of children fathered	2.0	2.3	4.8	2.2	0.4	1.4
Reason for reducing amount of alcohol drunk: Health precaution	3.8	4.4	5.9	1.9	2.4	1.9
Age at first live birth	0.2	0.4	0.9	-0.9	-0.4	0.1
Pulse wave peak to peak time	6.7	7.9	9.5	-3.1	-2.6	-2.7
Health satisfaction	0.6	0.8	1.2	0.1	1.1	1.0
Shortness of breath walking on level ground	1.0	1.2	2.1	-0.6	-1.4	-1.0
Qualifications: College or University degree	11.6	36.4	44.9	5.8	5.5	6.7
Eye problems/disorders: None of the above	4.9	5.6	9.7	-1.5	-3.1	-2.2
Mouth/teeth dental problems: Loose teeth	4.2	5.0	9.1	-1.5	-2.0	-3.0
Emphysema/chronic bronchitis	0.9	1.0	1.7	-1.3	-0.7	-0.9
Medication for pain relief, constipation, heartburn	1.3	2.2	3.4	0.9	1.5	1.8
Neck or shoulder pain in last month	1.3	1.8	4.3	0.6	2.1	0.9
Medication: Blood pressure	3.7	6.5	7.2	-2.7	-2.4	-2.5
Angina (self-reported)	0.5	0.7	1.2	1.1	0.1	0.9
Migraine (self-reported)	1.2	1.5	2.0	0.9	1.4	1.3
Medication: Ibuprofen	0.3	0.4	0.7	0.3	-0.6	-0.8
Medication: Allopurinol	0.9	1.2	2.9	-1.7	-0.4	-0.8
Medication: Omeprazole	0.9	1.1	2.3	0.6	1.5	0.7
Medication: Seretide 50 evohaler	1.2	1.3	3.5	0.1	1.9	0.7
Mean time to correctly identify matches	1.7	3.2	8.8	3.0	0.1	0.8
Heart disease (mother)	1.9	2.3	4.4	2.1	-1.5	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.2	-0.2	-1.5	-1.0
Whole body fat mass	30.9	128.8	161.3	-11.1	-10.1	-12.7
Leg fat mass (right)	23.5	91.2	112.4	-9.4	-8.6	-10.6
Arm predicted mass (right)	5.4	27.6	30.5	-5.5	-5.0	-5.2
Pulse rate, automated reading	2.0	6.5	11.6	0.1	-3.4	-2.8
Alcohol intake frequency.	24.6	57.2	73.7	-6.7	-7.3	-8.6
Comparative height size at age 10	5.8	31.9	33.3	-5.7	-5.5	-5.8
Number of full sisters	1.5	1.8	2.9	0.1	1.7	1.6
Suffer from ‘nerves’	11.6	18.2	26.9	-2.9	-4.4	-5.2
Overall health rating	4.2	8.9	10.9	-2.6	-3.0	-3.3
Chest pain or discomfort	0.4	0.6	1.3	-0.7	-0.3	-1.1
Had major operations	0.4	0.5	0.9	0.3	0.9	0.7
Age at last live birth	0.6	0.9	2.1	-0.1	-1.4	-0.7
Family relationship satisfaction	4.0	4.9	8.4	0.7	2.4	2.9
Leg pain on walking	0.9	1.2	2.3	1.5	0.8	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.5	-1.6	0.1	-0.5
Commuting to job workplace: Car/motor vehicle	1.8	2.1	4.0	-2.0	-0.7	-1.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.7	-0.4	0.2	-0.9
Medication: Aspirin	0.4	0.6	1.1	0.4	0.6	1.1
Supplements: Vitamin C	0.7	0.8	1.6	-1.3	-0.6	-0.8
Knee pain experienced in last month	1.2	1.9	2.5	-1.4	-1.1	-1.6
Hypertension (Self-reported)	3.2	9.0	13.4	-3.7	-2.7	-2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.1	3.6	5.1	1.8	2.3	1.6
Illnesses of father: Heart disease	0.2	0.2	0.5	0.4	-0.3	0.7
Illnesses of siblings: Diabetes	3.6	4.4	5.7	-2.4	-1.5	-2.3
Smoking status: Previous	3.6	5.3	9.1	1.6	2.1	3.0
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.6	11.0	-2.1	-3.3	-2.1
Whole body fat-free mass	7.6	43.7	46.6	-6.7	-6.3	-6.8
Leg fat-free mass (right)	15.0	80.0	93.1	-8.9	-8.2	-9.7
Arm fat percentage (left)	33.1	132.2	169.0	-11.3	-10.0	-13.0
Average weekly red wine intake	5.2	7.6	13.5	1.3	2.8	3.7
Handedness (chirality/laterality): Left-handed	6.6	7.9	14.0	-2.5	-1.8	-3.7
Mood swings	2.7	4.8	7.5	-1.2	-2.4	-2.7
Loneliness, isolation	1.8	2.5	3.5	-1.0	-1.7	-1.9
Long-standing illness, disability or infirmity	4.7	7.2	10.7	-2.3	-2.3	-3.3
Ever had bowel cancer screening	1.2	1.4	1.6	1.3	1.2	1.0
Diabetes diagnosed by doctor	3.7	6.1	11.2	-2.0	-1.7	-3.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.2	-0.3	0.7
Friendships satisfaction	2.5	3.2	5.3	0.6	1.9	2.3
Qualifications: nursing, teaching	1.2	1.8	3.7	0.8	1.0	1.9
Commuting to job workplace: Walk	0.5	0.5	0.9	0.9	-0.7	-0.5
Eye problems/disorders: Cataract	4.4	5.1	10.7	1.0	3.3	1.9
Mouth/teeth dental problems: Mouth ulcers	3.6	5.8	7.2	2.0	2.5	2.7
Medication for cholesterol	0.2	0.3	0.7	-0.1	-0.8	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	3.4	-1.2	-0.7	-1.8
Back pain experienced in last month	0.1	0.2	0.3	-0.4	0.6	-0.1
Mineral and other dietary supplements	0.3	0.5	0.8	0.2	-0.8	-0.9
Breast cancer (self-reported)	0.1	0.1	0.2	0.5	-0.2	-0.2
Asthma (self-reported)	0.3	0.6	1.5	1.2	0.0	0.5
Osteoporosis (self-reported)	2.1	2.7	4.7	0.2	2.2	1.8
Osteoarthritis (self-reported)	0.4	0.5	1.3	-0.3	-0.3	-1.2
Medication: Aspirin	0.2	0.2	0.5	0.1	0.3	0.7
Medication: Gliclazide	3.7	4.2	7.9	-1.2	-1.8	-2.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.7	-0.4	0.6	0.9
Smoking status: Current	1.8	2.9	6.2	-1.5	-0.4	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.5	11.6	17.1	2.6	3.3	4.1
Whole body water mass	7.3	41.8	44.4	-6.6	-6.1	-6.7
Leg predicted mass (right)	14.9	79.7	92.9	-8.9	-8.2	-9.6
Arm fat mass (left)	30.6	125.7	156.2	-11.1	-9.9	-12.5
Number of self-reported non-cancer illnesses	1.5	2.7	4.1	-1.2	-1.5	-2.0
Average weekly champagne plus white wine intake	2.4	3.3	5.8	1.9	0.8	2.4
Miserableness	4.1	7.1	11.2	-2.4	-2.1	-3.3
Guilty feelings	0.1	0.2	0.4	0.6	-0.2	-0.2
Wears glasses or contact lenses	0.5	0.5	1.3	-0.2	-1.1	-0.5
Ever taken oral contraceptive pill	3.2	3.5	5.9	2.4	1.1	1.8
Hearing aid user	0.5	0.6	0.8	0.7	-0.7	-0.9
Mother’s age at death	1.1	1.3	2.1	-0.1	1.4	1.4
Financial situation satisfaction	0.1	0.1	0.2	0.4	-0.5	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.7	-0.8	-0.5	-0.4
Commuting to job workplace: Public transport	1.9	2.3	3.4	1.5	1.1	1.8
Eye problems/disorders: Glaucoma	1.1	1.3	3.6	1.9	0.3	0.6
Medication: Blood pressure	0.4	0.8	1.4	-1.2	-0.4	-0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.4	0.2	-0.6	-1.2
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.7	0.4	0.4	1.3
High cholesterol (Self-reported)	0.2	0.3	0.6	0.2	0.4	-0.8
Medication: Bendroflumethiazide	1.6	2.4	4.0	-2.0	-0.8	-1.5
Medication: Paracetamol	6.2	9.6	14.0	-2.3	-3.1	-3.7
Medication: Lisinopril	1.7	2.2	3.6	-1.9	-0.8	-1.5
Medication: Atorvastatin	1.2	1.5	2.0	1.3	0.8	1.4
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.4	-0.1	-0.4
Alcohol drinker status: Never	5.1	6.2	7.5	-2.3	-2.4	-2.7
Ever smoked	3.4	6.0	7.4	1.9	2.7	2.6
Basal metabolic rate	11.4	63.3	69.7	-8.1	-7.4	-8.3
Leg fat percentage (left)	17.5	63.4	80.6	-8.1	-6.6	-9.0
Arm fat-free mass (left)	6.4	32.5	34.7	-5.9	-5.3	-5.9
Number of operations (self-reported)	0.3	0.4	0.9	1.0	-0.1	-0.5
Average weekly beer plus cider intake	0.8	1.2	2.0	-1.2	-0.5	-1.4
Irritability	0.4	0.6	1.6	0.2	0.5	1.3
Risk taking	5.3	7.8	11.5	1.1	3.4	3.3
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.6	0.1	0.8	0.4
Fractured/broken bones in last 5 years	0.6	0.7	1.4	-1.2	-0.3	-0.8
Age started oral contraceptive pill	0.2	0.2	0.5	0.4	0.7	0.0
Diastolic blood pressure, automated reading	2.6	7.9	9.7	-2.8	-3.1	-2.5
Ever depressed for a whole week	1.5	1.8	4.7	0.5	0.8	2.2
Unable to work because of sickness or disability	1.4	1.8	3.4	-1.8	-1.0	-1.0
Commuting to job workplace: Cycle	0.4	0.4	0.7	-0.1	0.8	0.8
Myopia	2.7	4.0	6.0	2.4	0.6	2.5
Vascular/heart problems diagnosed by doctor	2.2	6.1	10.8	3.3	2.0	1.8
Cholesterol lowering medication	0.8	1.2	2.6	1.6	0.9	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	0.2	0.6	0.4
Pain experienced in last month	0.1	0.2	0.4	0.6	0.0	0.6
Supplements: Calcium	2.7	3.0	5.4	1.7	0.9	2.3
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	0.6	0.6	1.2
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.1	-2.0	-0.9	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.8	1.3	0.1	0.1
Heart disease (siblings)	0.3	0.4	0.6	0.5	0.8	0.4
Alcohol drinker status: Previous	2.9	3.3	4.4	-1.8	-1.5	-2.1
Pack years of smoking	7.0	10.4	14.3	-2.0	-3.8	-3.6
Impedance of whole body	0.3	1.6	2.1	1.4	1.0	1.3
Leg fat mass (left)	24.3	95.1	116.6	-9.7	-8.7	-10.8
Arm predicted mass (left)	6.3	32.2	35.4	-6.0	-5.2	-5.8