Hub : Genes

RP11-23P13.6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.132	0.052	0.0036	0.015	NA	0.015	NA	0.015	2.0e-02	NA	0.02100	NA	0.01900
2	GTEx	Brain Cerebellum	0.164	0.075	0.0073	0.141	NA	0.111	NA	0.107	5.9e-05	NA	0.00036	NA	0.00045
3	GTEx	Heart Atrial Appendage	0.261	0.089	0.0011	-0.006	NA	0.012	NA	0.008	8.8e-01	NA	0.08600	NA	0.14000
4	GTEx	Thyroid	0.071	0.032	0.0083	0.005	NA	0.002	NA	0.006	1.3e-01	NA	0.23000	NA	0.09600

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.7	2.8	1.7	0.3	-0.1	0.0
Bipolar Disorder or Schizophrenia	0.3	0.7	2.8	1.7	0.0	-0.2	0.2
Depressed Affect (Nagel 2018)	0.7	1.5	2.0	-0.8	1.4	-1.4	-1.2
Depression (Nagel 2018)	0.5	0.8	2.8	-0.2	-0.5	-1.7	-0.4
Intelligence (Savage-Jansen 2018)	2.7	8.3	15.1	3.1	0.1	2.9	3.9
Neuroticism (Nagel 2018)	0.4	1.0	2.2	-0.1	0.9	-1.0	-1.5
Schizophrenia (2018)	0.1	0.3	0.9	0.9	-0.2	-0.2	0.3
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	-0.6	0.5	-0.2	0.3
Worry (Nagel 2018)	0.6	1.2	4.2	0.3	2.1	0.3	-0.6
Alzheimer’s Disease (in mother)	0.6	0.7	1.8	0.7	0.5	0.5	1.3
Alzheimer’s Disease (in father)	0.9	1.0	3.5	0.5	1.9	0.3	-0.2
Alzheimer’s Disease (including proxy)	0.5	0.7	1.0	0.7	1.0	0.7	0.9
Crohns Disease (2017)	0.2	0.4	1.6	-1.3	0.4	-0.1	-0.1
Irritable Bowel Disease (IBD)	0.1	0.1	0.2	-0.4	0.4	-0.3	-0.3
Ulcerative Colitis (UC)	0.2	0.4	0.8	-0.2	0.3	-0.9	-0.7
Major Depression (MDD)	1.6	1.9	3.9	0.9	-0.6	-1.6	-2.0
Reaction Time	3.7	7.1	13.3	0.4	-1.5	-3.6	-3.5
Verbal and Numeric Reasoning (VNR)	2.5	6.0	11.2	3.1	-0.7	1.6	3.3
Breast Cancer	1.3	3.1	6.5	-0.7	2.5	2.2	0.8
Ovarian Cancer	0.8	1.0	1.5	-1.2	-0.5	-1.2	-1.0
Prostate Cancer	0.3	0.4	1.3	-0.1	-0.5	-0.4	-1.1
Age at First Birth	0.3	0.5	1.9	-0.1	-0.1	-0.1	1.4
Bipolar Disorder (2011)	0.3	0.3	0.7	0.9	-0.4	0.0	-0.6
Body Mass Index (BMI) (2010)	1.1	1.5	2.5	1.2	0.5	1.6	1.2
Coronary Artery Disease (CAD)	0.4	0.5	1.3	0.1	-1.1	-0.0	-0.8
Crohns Disease (2012)	1.7	2.7	3.8	-0.9	1.8	1.7	2.0
Mean Putamen Volume	0.2	0.2	0.5	0.7	-0.0	-0.6	0.3
Fasting Glucose	0.6	0.8	1.4	1.1	-1.2	-0.8	0.0
HbA1C	1.1	1.2	3.2	1.8	-0.7	-0.3	-1.0
HDL Cholesterol	1.6	2.6	3.8	-1.1	1.9	1.7	1.6
LDL Cholesterol	0.1	0.2	0.4	0.3	-0.2	-0.6	-0.6
Lupus	0.2	0.3	0.5	0.3	-0.7	-0.7	-0.6
Neuroticism (2016)	1.9	2.7	6.3	1.0	-1.7	-0.8	-2.5
Primary Biliary Cirrhosis	0.1	0.2	0.3	0.2	-0.5	-0.3	-0.5
Rheumatoid Arthritis	1.4	1.9	6.2	-1.1	0.4	-2.5	-0.3
Schizophrenia (2014)	0.2	0.5	0.9	1.0	-0.3	-0.7	0.6
Triglycerides	3.4	5.6	8.4	1.3	-2.9	-2.4	-2.5
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.7	-0.8	-0.1	-0.5	-1.3
Ulcerative Colitis	0.3	0.4	0.6	-0.5	0.8	-0.6	0.5
Blood Eosinophil Count	1.2	8.9	29.5	-0.5	-5.4	-2.4	0.0
Blood Platelet Count	0.2	2.1	5.1	-1.4	-0.3	-2.3	-1.1
Blood Red Count	1.0	9.3	19.4	1.3	-3.5	-4.4	-2.1
Blood White Count	2.2	16.1	39.3	-2.1	-2.4	-6.3	-3.8
Heel T-Score	0.4	2.9	9.2	-0.4	0.9	1.2	3.0
BMI	0.6	3.4	11.6	-0.6	-0.1	1.3	3.4
Height	0.5	10.3	25.7	-0.4	-3.9	-0.2	5.1
Waist Hip Ratio (WHR)	3.6	16.2	24.7	0.1	-4.3	-4.6	-5.0
Systolic Blood Pressure	2.3	11.4	19.0	2.1	-4.4	-2.9	-3.7
Smoking Status	0.8	2.0	3.0	0.6	-1.6	-1.4	-1.7
Allergy or Eczema	0.5	1.2	2.2	1.0	-1.5	-0.1	1.4
Cardiovascular Disease	3.2	10.7	17.1	-0.5	-4.1	-3.7	-3.4
Hypothyroidism (self reported)	1.9	4.4	12.1	0.7	-3.5	-1.9	-1.3
Respiratory disease	1.0	2.2	3.8	1.6	-1.3	-1.9	-0.8
Type 2 Diabetes (T2D) (2018)	3.3	6.1	16.4	-1.0	-2.4	-1.2	-4.0
Lung FEV1/FVC ratio	5.0	25.4	67.9	0.9	-8.2	-4.0	-4.2
Lung FVC	1.0	4.9	10.1	-1.5	2.6	0.7	3.2
Neuroticism	0.5	1.1	4.0	0.4	2.0	0.2	-0.5
Chronotype (morning person)	0.9	2.1	5.5	-0.7	2.3	0.6	1.4
Hair Pigment	0.0	0.6	1.0	-0.9	0.1	-1.0	0.8
Tanning	0.1	1.2	2.1	-1.5	0.8	-1.4	-0.3
Hand grip strength (left)	0.3	0.9	1.7	-0.8	0.7	-1.3	0.9
Number of treatments/medications taken	4.1	7.4	15.1	-0.7	-3.9	-2.7	-2.5
Average weekly spirits intake	0.9	1.1	2.1	-0.4	0.6	-1.4	-1.5
Sensitivity / hurt feelings	0.8	1.4	2.3	1.3	0.2	-1.3	-1.5
Frequency of depressed mood in last 2 weeks	1.7	2.4	5.4	0.6	-1.0	-2.3	-1.7
Hearing difficulty/problems: Yes	1.5	2.3	7.5	-2.7	0.5	-0.5	1.1
Relative age of first facial hair	0.4	0.7	1.3	-0.6	-1.1	-0.2	1.1
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	4.3	0.8	-1.5	-2.1	-2.1
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.8	1.7	-0.6	0.0	-1.5
Ever had hysterectomy (womb removed)	1.5	1.7	4.0	-0.6	-0.0	-1.6	-2.0
Systolic blood pressure, automated reading	1.0	2.8	8.2	1.2	-2.9	-0.8	-1.1
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	5.0	0.0	-0.6	0.6	-2.2
Angina	0.7	1.0	2.0	-0.6	-0.1	1.2	1.4
Medication for hormone replacement therapy	0.7	0.8	1.7	1.1	1.3	0.6	0.2
Vitamin and mineral supplements	0.5	0.7	1.3	-0.5	1.2	0.6	0.8
Supplements: Zinc	1.8	2.0	3.0	0.0	-1.6	-1.6	-1.7
Medication: Co-codamol	0.8	0.9	1.8	-1.2	-0.2	-0.4	-1.3
Medication: Metformin	3.3	4.6	8.1	0.0	-2.6	-1.9	-2.8
Diabetes (father)	4.0	5.0	14.3	1.0	-3.8	-1.8	-1.1
Diabetes (mother)	3.9	4.9	5.7	1.9	-2.2	-2.4	-2.4
Severe depression (siblings)	1.0	1.1	3.8	-0.9	1.9	-0.1	0.0
Pack years adult smoking proportion	0.8	1.2	2.9	1.7	-0.4	1.3	-0.6
Impedance of leg (right)	2.8	13.7	32.9	-0.7	-2.6	-3.9	-5.7
Leg fat-free mass (left)	1.7	8.8	25.5	1.0	1.0	2.8	5.0
Trunk fat percentage	0.5	1.9	3.5	1.2	-1.5	-1.9	0.8
Hand grip strength (right)	0.4	1.0	2.9	-0.2	-0.2	-1.7	1.0
Townsend deprivation index at recruitment	1.0	1.3	2.7	-1.2	0.6	-1.0	-1.6
Current tobacco smoking	0.9	1.5	2.9	1.2	-1.1	-0.7	-1.7
Average weekly fortified wine intake	0.3	0.4	0.9	-0.9	-0.4	0.6	-0.1
Maternal smoking around birth	0.6	0.8	1.7	-1.3	0.1	-1.2	-0.4
Fed-up feelings	1.4	2.6	4.1	1.5	1.2	-1.5	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.9	0.4	-0.5	-1.7	-0.7
Relative age voice broke	1.3	1.9	4.3	1.1	-2.1	-1.2	1.0
Taking other prescription medications	0.9	1.4	3.3	0.4	-1.8	-1.0	-1.1
Age when periods started (menarche)	1.0	2.5	6.6	0.6	-0.6	-1.6	-2.6
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.4	1.3	-0.6	0.5	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.7	0.0	0.1	0.6	1.3
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	5.0	0.5	-0.6	-0.5	-2.2
Qualifications: CSEs or equivalent	1.3	1.7	5.7	0.0	1.1	0.0	-2.4
Serious illness, injury or assault to yourself	2.3	2.8	8.2	-0.7	-1.5	-0.6	-2.9
High blood pressure	3.0	8.4	13.6	0.5	-3.7	-3.5	-2.8
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.0	0.6	-2.0	-0.0	1.6
Multivitamins +/- minerals	1.1	1.4	2.6	1.6	-1.5	-0.5	-0.6
Stomach or abdominal pain in last month	0.5	0.6	2.5	-0.1	0.3	0.0	-1.6
Supplements: Glucosamine	0.6	0.7	1.4	-0.4	1.2	0.2	-1.1
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	11.7	3.4	0.7	0.5	-0.5
Medication: Atenolol	0.3	0.4	1.2	-0.4	-0.5	1.1	0.3
Medication: Levothyroxine sodium	2.8	4.8	7.2	-0.3	-2.7	-2.3	-2.6
Sitting height	0.7	5.1	14.8	-0.6	0.4	2.2	3.9
Chronic bronchitis/emphysema (father)	0.4	0.5	1.7	0.1	1.3	-0.4	-0.5
High blood pressure (mother)	2.6	3.7	9.0	-0.4	-1.4	-1.9	-3.0
Body mass index (BMI)	0.5	1.9	6.4	1.0	-0.6	-0.2	2.5
Impedance of leg (left)	2.7	13.3	32.5	-1.4	-2.0	-3.9	-5.7
Leg predicted mass (left)	1.7	9.0	26.2	1.1	1.0	2.8	5.1
Trunk fat mass	0.5	2.0	4.1	1.2	-1.2	-0.9	2.0
Waist circumference	0.7	2.5	4.5	1.6	-2.1	-1.2	1.3
Number of incorrect matches in round	0.9	1.4	2.5	-0.6	-0.7	-1.6	-1.5
Past tobacco smoking	0.9	1.6	5.2	-0.4	-0.2	2.3	0.9
Alcohol usually taken with meals	2.6	4.2	8.1	0.0	0.9	2.8	2.8
Nervous feelings	0.7	1.4	3.1	1.8	1.5	0.2	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	3.7	1.6	-0.2	-1.9	-1.5
Hearing difficulty/problems with background noise	0.7	1.1	1.9	-1.4	0.7	-0.1	1.3
Hair/balding pattern: Pattern 2	0.8	1.0	2.1	1.4	1.3	-0.3	0.2
Had menopause	0.6	0.7	1.7	1.3	-0.0	0.9	0.6
Had other major operations	1.1	1.3	1.9	0.3	1.3	1.2	1.4
Forced vital capacity (FVC)	0.8	2.9	3.8	-1.9	1.9	0.7	1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	4.4	-0.9	0.9	1.7	2.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	0.1	0.4	0.4	-1.0
Qualifications: None of the above	0.2	0.4	0.9	-0.9	0.1	-0.2	0.9
Financial difficulties in last 2 years	3.0	4.0	8.6	0.1	-1.0	-2.5	-2.9
Mouth/teeth dental problems	0.1	0.2	0.3	0.1	-0.4	0.5	-0.4
Heart attack	0.4	0.5	1.1	-1.1	-0.3	0.2	-1.0
Allergy	1.0	2.3	5.9	-1.6	2.4	0.4	-0.8
Pain all over the body in last month	2.3	2.4	4.9	-2.2	-0.4	-1.0	-1.9
Diabetes (self-reported)	3.1	4.8	13.1	0.3	-2.2	-1.2	-3.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.8	0.3	-0.4	-1.7	0.1
Medication: Ramipril	1.8	2.3	5.6	-0.6	0.3	-1.8	-2.4
Medication: Simvastatin	1.3	1.9	2.7	0.5	-1.5	-1.5	-1.6
Fluid intelligence score	2.1	4.3	8.4	2.9	-0.8	2.1	2.0
Illnesses of siblings	0.9	1.3	2.0	-1.1	1.2	1.4	-0.5
Neuroticism score	1.0	2.0	4.6	1.7	2.1	0.0	-0.6
Weight	0.9	4.4	16.2	0.8	-0.4	0.8	4.0
Impedance of arm (right)	1.6	7.2	17.5	0.6	-2.0	-2.7	-4.2
Arm fat percentage (right)	0.4	1.5	2.7	1.2	-1.3	-1.6	0.6
Trunk fat-free mass	1.4	8.2	25.0	0.0	0.5	2.8	5.0
Hip circumference	1.0	4.2	14.3	1.4	-0.0	0.6	3.8
Time employed in main current job	1.1	1.2	3.3	0.7	-0.1	-1.8	-1.1
Alcohol intake versus 10 years previously	1.7	2.5	5.1	0.4	-1.1	-2.2	-1.9
Father’s age at death	5.1	6.9	12.3	-1.1	3.5	2.6	2.6
Worrier / anxious feelings	1.1	2.0	6.5	2.6	1.2	0.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.9	-0.9	0.6	-0.3	-0.3
Falls in the last year	1.7	2.2	5.6	-1.0	-2.4	-0.6	-1.4
Hair/balding pattern: Pattern 3	0.6	0.9	1.3	-1.1	-1.1	-0.3	0.9
Number of live births	2.7	3.8	5.8	1.7	-1.3	-2.2	-2.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.9	-1.4	-0.3	-0.2	0.6
Pulse rate	0.4	0.7	1.9	1.0	-0.1	-0.4	-1.4
Happiness	0.7	0.8	1.3	1.1	0.8	0.8	-0.9
Noisy workplace	0.8	1.0	2.5	1.0	-0.0	-1.6	-0.8
Qualifications: A levels/AS levels or equivalent	1.6	3.6	9.5	-0.7	0.5	3.1	2.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.3	0.2	-0.4	-0.1
Mouth/teeth dental problems: Dentures	1.5	2.6	3.6	1.7	-1.2	-1.9	-1.6
Asthma	0.7	1.4	2.4	0.9	-0.9	-1.6	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.6	-0.5	-1.0	-0.4	-1.6
Medication: Cholesterol lowering	2.3	3.6	9.9	-0.1	-3.1	-2.0	-0.7
Depression (self-reported)	0.3	0.4	0.9	-0.9	0.1	-0.8	0.3
Medication: Lansoprazole	0.9	1.1	3.3	0.2	-0.6	-0.8	-1.8
Prospective memory result	0.4	0.4	0.8	0.8	-0.6	0.1	-0.9
Lung cancer (father)	0.2	0.3	0.4	0.0	-0.6	-0.6	0.7
Illnesses of mother	0.5	0.6	1.1	0.8	0.7	1.0	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.7	-1.7	-1.0	-0.4	-0.1
Pulse wave Arterial Stiffness index	0.7	0.8	1.5	0.3	-0.4	1.2	1.2
Impedance of arm (left)	1.3	5.8	15.8	0.6	-1.3	-2.4	-4.0
Arm fat mass (right)	0.4	1.8	4.1	1.2	-1.2	-0.7	2.0
Trunk predicted mass	1.4	8.2	24.5	0.0	0.6	2.9	4.9
Standing height	0.4	3.6	10.5	-0.2	-0.4	1.9	3.2
Length of working week for main job	0.2	0.2	0.4	0.5	0.6	0.3	-0.4
Exposure to tobacco smoke at home	1.2	1.3	3.1	1.2	-1.8	-0.6	0.5
Breastfed as a baby	0.3	0.4	0.9	0.1	0.8	0.2	0.9
Tense / ‘highly strung’	0.4	0.6	1.3	0.0	1.1	-1.0	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	6.0	0.1	-0.5	-2.4	-2.0
Hair/balding pattern: Pattern 4	0.5	1.1	2.7	-0.3	1.2	0.5	1.6
Birth weight of first child	0.4	0.8	1.9	-0.8	-0.7	-1.4	-0.3
Peak expiratory flow (PEF)	0.3	0.7	2.4	-1.5	-0.5	0.0	0.5
Pulse wave reflection index	0.4	0.5	1.8	0.3	-1.3	-0.4	0.3
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.9	-0.3	-1.0	-0.2	-1.4
Loud music exposure frequency	0.3	0.3	1.1	0.1	-0.4	-1.1	0.1
Qualifications: O levels/GCSEs or equivalent	0.8	1.4	4.1	0.1	0.3	2.0	1.1
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	2.8	-1.5	0.9	1.3	1.7
Blood clot in the leg (DVT)	0.6	0.8	1.6	0.3	-1.1	-1.3	-0.6
Medication: Paracetamol	2.9	4.7	9.8	-0.3	-1.8	-2.4	-3.1
Headache pain in last month	1.2	2.1	5.1	2.3	-1.2	-1.2	-0.5
Medication for cholesterol, blood pressure or diabetes	2.9	4.7	9.0	0.8	3.0	2.6	1.6
Glaucoma (self-reported)	0.8	0.9	2.5	0.4	-0.6	0.8	1.6
Gout (self-reported)	0.3	0.4	0.5	0.3	0.7	0.7	0.6
Hypothyroidism/myxoedema (self-reported)	3.1	6.0	11.3	0.6	-3.4	-2.7	-2.3
Medication: Amlodipine	2.7	3.7	5.4	1.9	-1.8	-2.3	-1.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	-0.9	-0.8	-0.3	-0.0
Birth weight	0.1	0.2	0.6	-0.8	-0.5	0.0	0.1
Chronic bronchitis/emphysema (mother)	1.0	1.2	1.3	-1.1	-1.1	-1.1	-1.1
High blood pressure (siblings)	1.5	2.2	4.1	1.2	-2.0	-1.7	0.4
Forced vital capacity (FVC), Best measure	0.7	2.5	5.3	-2.3	1.1	1.2	1.4
Body fat percentage	0.4	1.6	3.1	1.0	-1.3	-1.8	0.7
Leg fat percentage (right)	0.5	1.7	3.7	1.2	-1.3	-1.9	0.2
Arm fat-free mass (right)	1.7	8.5	25.7	0.2	1.0	2.7	5.1
Exposure to tobacco smoke outside home	1.0	1.4	3.9	-1.1	0.3	-0.4	2.0
Comparative body size at age 10	0.1	0.3	0.8	0.1	-0.5	0.9	0.1
Number of full brothers	3.8	4.8	10.5	0.8	-3.2	-2.5	-1.2
Worry too long after embarrassment	2.1	3.5	13.1	3.6	0.7	0.3	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	3.7	-1.9	-0.8	-1.0	-1.2
Wheeze or whistling in the chest in last year	1.3	2.3	3.6	1.8	-0.3	-1.9	-1.5
Number of children fathered	0.3	0.3	0.6	-0.8	0.5	-0.6	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	6.3	0.1	2.5	0.4	0.3
Age at first live birth	0.6	1.1	2.6	-0.9	0.7	1.6	0.7
Pulse wave peak to peak time	0.4	0.5	0.8	-0.2	0.6	-0.8	-0.9
Health satisfaction	0.5	0.6	1.8	-0.4	-0.6	-0.5	-1.3
Shortness of breath walking on level ground	1.9	2.2	5.5	-2.3	-1.4	-1.1	-0.5
Qualifications: College or University degree	0.2	0.6	1.5	-0.0	0.1	1.2	0.9
Eye problems/disorders: None of the above	0.4	0.5	1.3	1.2	0.4	-0.3	0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	0.1	0.3	0.6	0.9
Emphysema/chronic bronchitis	1.0	1.1	1.7	1.3	-1.3	0.6	0.8
Medication for pain relief, constipation, heartburn	2.8	4.7	7.6	0.8	2.8	2.2	2.4
Neck or shoulder pain in last month	0.5	0.7	2.2	1.5	-0.1	-0.5	-0.5
Medication: Blood pressure	2.0	3.5	6.0	-1.6	-1.3	-2.5	-1.9
Angina (self-reported)	0.8	1.1	2.4	-0.4	0.2	1.3	1.5
Migraine (self-reported)	0.7	0.9	3.3	-0.4	0.0	0.2	-1.8
Medication: Ibuprofen	0.8	1.0	1.9	-0.8	-1.1	-0.5	-1.4
Medication: Allopurinol	0.1	0.1	0.2	0.2	0.3	0.4	0.3
Medication: Omeprazole	0.8	0.9	2.5	-0.3	-0.4	-1.0	-1.6
Medication: Seretide 50 evohaler	0.4	0.5	1.0	-0.2	-1.0	-0.6	-0.6
Mean time to correctly identify matches	2.9	5.5	10.8	0.6	-1.4	-3.3	-3.0
Heart disease (mother)	0.0	0.0	0.1	-0.3	0.0	0.0	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	4.0	2.0	-0.3	-1.4	-1.1
Whole body fat mass	0.4	1.6	3.5	1.1	-1.1	-0.8	1.9
Leg fat mass (right)	0.4	1.4	2.9	1.1	-1.0	-0.8	1.7
Arm predicted mass (right)	1.6	8.4	24.6	0.2	1.1	2.8	5.0
Pulse rate, automated reading	0.5	1.6	2.8	1.0	0.4	-1.7	-1.5
Alcohol intake frequency.	2.3	5.4	9.4	1.4	-2.5	-3.1	-2.1
Comparative height size at age 10	0.1	0.4	1.3	-0.3	-1.2	-0.0	0.3
Number of full sisters	4.3	5.2	9.5	3.1	-0.1	-1.6	-3.0
Suffer from ‘nerves’	0.8	1.3	2.9	1.4	1.7	-0.3	-0.5
Overall health rating	0.6	1.3	3.2	0.4	-1.3	-0.4	-1.8
Chest pain or discomfort	0.7	1.0	2.7	0.8	-0.7	-1.6	-0.4
Had major operations	1.6	1.8	3.0	-1.7	-1.6	0.2	1.4
Age at last live birth	0.7	1.0	1.8	-1.3	1.4	0.5	0.4
Family relationship satisfaction	0.2	0.3	0.7	-0.9	0.2	-0.3	-0.5
Leg pain on walking	3.9	4.9	8.8	-1.6	-3.0	-1.9	-2.1
Qualifications: NVQ or HND or HNC or equivalent	5.8	6.9	15.0	1.2	-1.7	-2.9	-3.9
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.4	1.0	-0.2	-1.2	0.1
Illness, injury, bereavement, stress in last 2 years	3.6	4.5	8.5	-0.9	0.6	2.8	2.9
Medication: Aspirin	1.0	1.4	2.4	-1.3	-1.6	-0.9	-0.8
Supplements: Vitamin C	0.1	0.1	0.2	0.5	-0.4	0.1	-0.0
Knee pain experienced in last month	1.1	1.7	6.4	0.1	-0.5	-0.5	-2.5
Hypertension (Self-reported)	2.9	8.1	12.0	0.1	-3.3	-3.5	-3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.4	-0.6	-0.3	-0.3
Illnesses of father: Heart disease	1.1	1.5	2.1	1.4	-1.0	-1.4	-0.9
Illnesses of siblings: Diabetes	3.0	3.7	6.7	2.0	-2.0	-2.6	-0.5
Smoking status: Previous	1.0	1.5	4.7	0.6	-0.1	-2.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.9	-1.7	-0.6	-0.1	0.0
Whole body fat-free mass	1.6	9.3	27.7	0.5	0.9	2.9	5.3
Leg fat-free mass (right)	1.8	9.8	28.3	0.7	1.3	2.9	5.3
Arm fat percentage (left)	0.3	1.2	2.0	1.3	-0.9	-1.4	0.7
Average weekly red wine intake	0.6	0.9	1.4	-0.7	1.2	1.1	0.7
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.2	-0.8	1.0	1.0	1.1
Mood swings	0.6	1.0	2.4	0.6	1.1	0.2	-1.6
Loneliness, isolation	0.5	0.6	1.9	1.4	0.7	-0.3	-0.3
Long-standing illness, disability or infirmity	1.8	2.8	8.7	-0.1	-0.4	-1.5	-3.0
Ever had bowel cancer screening	0.2	0.3	0.5	0.6	-0.1	0.7	0.6
Diabetes diagnosed by doctor	4.2	6.9	15.0	0.4	-3.0	-1.8	-3.9
Ever had stillbirth, spontaneous miscarriage or termination	1.8	2.0	4.9	2.2	0.0	-0.8	-1.5
Friendships satisfaction	0.3	0.4	1.0	-0.0	0.5	-0.4	-1.0
Qualifications: nursing, teaching	0.8	1.2	2.1	-0.5	-0.9	1.3	1.4
Commuting to job workplace: Walk	0.6	0.6	2.1	-0.3	1.4	0.4	0.5
Eye problems/disorders: Cataract	1.6	1.8	4.6	-0.7	1.5	2.1	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.1	0.4	1.1	0.0	0.0
Medication for cholesterol	0.6	1.0	2.7	-0.8	0.4	0.6	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	5.6	0.6	-2.4	-1.7	-1.3
Back pain experienced in last month	0.8	1.2	3.6	-0.1	1.9	0.9	-0.3
Mineral and other dietary supplements	2.5	3.3	6.1	-0.2	2.1	1.7	2.5
Breast cancer (self-reported)	1.1	1.3	3.2	0.3	0.1	1.4	1.8
Asthma (self-reported)	0.6	1.2	2.0	1.0	-0.8	-1.4	-1.0
Osteoporosis (self-reported)	0.7	0.9	2.2	-0.8	0.4	-0.6	1.5
Osteoarthritis (self-reported)	0.2	0.3	1.0	-0.4	-0.3	1.0	-0.2
Medication: Aspirin	1.1	1.4	2.5	-1.5	-1.6	-0.7	-0.6
Medication: Gliclazide	5.1	5.7	9.5	-0.8	-2.9	-2.1	-3.1
Illnesses of father: None of the above (group 1)	0.7	0.9	3.5	-1.9	0.2	0.1	-0.3
Smoking status: Current	0.8	1.3	2.4	1.1	-1.1	-0.7	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.0	-1.7	-0.6	-0.8	-1.0
Whole body water mass	1.6	9.2	26.7	0.5	1.0	3.0	5.2
Leg predicted mass (right)	1.8	9.7	28.1	0.7	1.3	3.0	5.3
Arm fat mass (left)	0.4	1.7	4.4	1.3	-0.7	-0.4	2.1
Number of self-reported non-cancer illnesses	2.3	4.0	7.8	0.6	-1.6	-2.8	-2.2
Average weekly champagne plus white wine intake	2.1	2.8	5.0	-1.8	2.2	1.4	1.0
Miserableness	0.6	1.1	2.5	-0.6	1.6	-0.2	-1.1
Guilty feelings	1.1	1.6	3.1	1.2	-1.8	-1.0	-1.0
Wears glasses or contact lenses	2.1	2.4	5.9	-1.7	0.3	-1.0	2.4
Ever taken oral contraceptive pill	0.2	0.2	0.3	-0.6	-0.5	0.4	0.2
Hearing aid user	0.4	0.4	0.9	-0.3	-0.6	-0.9	-0.5
Mother’s age at death	2.3	2.9	4.7	2.0	1.0	1.4	2.2
Financial situation satisfaction	1.0	1.3	4.4	-0.8	0.3	0.1	-2.1
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.0	-0.3	-0.4	-1.7	-1.4
Commuting to job workplace: Public transport	0.3	0.4	0.7	-0.8	0.3	0.4	-0.8
Eye problems/disorders: Glaucoma	0.5	0.6	1.3	-0.1	-1.1	-1.0	0.5
Medication: Blood pressure	1.0	1.9	2.4	1.1	-1.5	-1.4	-1.4
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.7	-0.0	0.6	-0.6	-1.3
Supplements: Fish oil (including cod liver oil)	1.5	1.9	4.7	0.4	-1.3	-1.2	-2.2
High cholesterol (Self-reported)	1.3	2.3	3.2	1.1	-1.7	-1.8	-1.3
Medication: Bendroflumethiazide	1.2	1.8	3.3	0.1	-1.8	-1.8	-0.8
Medication: Paracetamol	2.5	3.9	7.8	-0.4	-2.0	-1.9	-2.8
Medication: Lisinopril	0.3	0.4	1.1	0.5	-1.1	-0.1	0.3
Medication: Atorvastatin	0.6	0.7	2.6	-0.1	-1.6	0.4	-0.4
Illnesses of father: High blood pressure	0.2	0.3	0.8	0.3	-0.9	-0.1	0.5
Alcohol drinker status: Never	2.6	3.1	4.6	0.5	-2.1	-2.2	-1.7
Ever smoked	0.6	1.1	2.5	0.0	1.6	-1.4	-0.0
Basal metabolic rate	1.5	8.1	25.1	0.6	0.7	2.5	5.0
Leg fat percentage (left)	0.4	1.4	3.9	0.7	-1.1	-2.0	0.3
Arm fat-free mass (left)	1.3	6.5	20.5	0.2	0.7	2.3	4.5
Number of operations (self-reported)	0.9	1.4	2.8	-1.7	-0.4	-1.5	-0.5
Average weekly beer plus cider intake	0.2	0.3	1.1	1.0	-0.4	-0.0	-0.0
Irritability	0.6	1.1	2.3	-1.5	0.6	-0.8	1.0
Risk taking	0.2	0.3	0.9	-0.3	-0.1	-0.5	-0.9
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.9	0.3	-2.0	-1.4	-0.2
Fractured/broken bones in last 5 years	1.0	1.4	4.0	-0.1	-2.0	-1.2	0.1
Age started oral contraceptive pill	0.9	1.2	1.8	1.4	-0.2	1.2	1.1
Diastolic blood pressure, automated reading	4.1	12.8	27.8	1.5	-5.3	-2.7	-3.7
Ever depressed for a whole week	0.6	0.7	2.6	0.1	0.1	-0.5	-1.6
Unable to work because of sickness or disability	2.1	2.8	5.7	-2.4	0.1	-1.3	-1.9
Commuting to job workplace: Cycle	1.5	1.8	5.1	-0.2	1.3	2.3	0.5
Myopia	0.1	0.2	0.6	0.7	-0.2	0.3	0.3
Vascular/heart problems diagnosed by doctor	2.1	5.8	12.0	0.2	3.5	2.6	2.1
Cholesterol lowering medication	0.4	0.5	1.1	0.7	0.0	0.7	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.9	0.2	-0.5	-1.1	-1.7
Pain experienced in last month	0.6	0.9	2.8	-0.5	0.0	0.8	1.7
Supplements: Calcium	0.6	0.7	1.3	-0.8	-0.7	-1.1	-0.5
Basal cell carcinoma (self-reported)	0.8	0.9	1.6	-0.1	-1.2	-1.3	0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	-1.4	-0.1	-0.1	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.6	0.5	-1.1	-1.3	-0.3
Heart disease (siblings)	0.9	1.0	1.8	1.0	1.1	0.5	-1.3
Alcohol drinker status: Previous	0.1	0.1	0.1	-0.4	0.2	-0.0	-0.4
Pack years of smoking	1.0	1.5	3.9	2.0	-0.6	1.2	-0.3
Impedance of whole body	2.0	10.4	27.9	-0.4	-1.7	-3.3	-5.3
Leg fat mass (left)	0.3	1.3	3.0	0.8	-0.8	-0.8	1.7
Arm predicted mass (left)	1.2	6.3	19.8	0.2	0.7	2.3	4.4