Hub : Genes

RP11-247A12.1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0710	0.0310	6.3e-03	0.036	NA	0.041	NA	0.034	9.4e-04	NA	5.0e-04	NA	1.3e-03
2	GTEx	Colon Transverse	0.1200	0.0460	1.9e-03	0.103	NA	0.034	NA	0.082	1.4e-05	NA	9.2e-03	NA	9.8e-05
3	GTEx	Esophagus Mucosa	0.2350	0.0560	2.1e-09	0.132	NA	0.164	NA	0.163	3.8e-09	NA	4.2e-11	NA	4.6e-11
4	GTEx	Heart Left Ventricle	0.1418	0.0489	1.5e-04	0.107	NA	0.121	NA	0.132	2.6e-06	NA	5.4e-07	NA	1.7e-07
5	GTEx	Muscle Skeletal	0.0829	0.0259	9.4e-06	0.097	NA	0.086	NA	0.094	8.7e-10	NA	9.0e-09	NA	1.8e-09
6	GTEx	Pancreas	0.2740	0.0550	6.5e-10	0.350	NA	0.330	NA	0.355	1.4e-15	NA	1.4e-14	NA	8.4e-16
7	GTEx	Whole Blood	0.0990	0.0370	9.9e-04	0.032	NA	0.011	NA	0.014	5.8e-04	NA	2.9e-02	NA	1.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.2	0.4	0.8	-0.5	-0.5	-0.9	-0.5	-0.5	0.6	-0.4
Bipolar Disorder or Schizophrenia	2.2	5.4	10.3	-2.0	-2.2	-3.2	-2.2	-2.1	2.5	-1.8
Depressed Affect (Nagel 2018)	0.0	0.1	0.5	-0.2	0.0	-0.0	0.7	0.1	-0.4	0.1
Depression (Nagel 2018)	0.4	0.6	1.0	-0.8	-0.8	-0.6	-0.7	-1.0	0.7	-0.8
Intelligence (Savage-Jansen 2018)	10.9	33.5	35.2	-5.9	-5.7	-5.8	-5.6	-5.7	5.9	-5.8
Neuroticism (Nagel 2018)	0.0	0.0	0.1	-0.1	-0.3	-0.2	0.2	-0.3	-0.1	-0.2
Schizophrenia (2018)	3.0	6.3	11.6	-2.1	-2.4	-3.4	-2.4	-2.3	2.7	-2.0
Schizophrenia vs Biploar Disorder	0.8	1.1	1.9	-1.0	-1.0	-1.0	-1.4	-0.9	1.2	-0.9
Worry (Nagel 2018)	0.3	0.7	1.3	1.1	0.5	1.1	0.9	0.6	-0.9	0.5
Alzheimer’s Disease (in mother)	1.5	1.7	2.4	0.8	1.3	1.5	1.3	1.3	-1.4	1.4
Alzheimer’s Disease (in father)	0.2	0.2	0.8	0.9	0.3	0.6	-0.2	0.3	-0.3	0.4
Alzheimer’s Disease (including proxy)	0.3	0.5	0.6	0.7	0.8	0.7	0.5	0.8	-0.7	0.7
Crohns Disease (2017)	4.0	8.7	10.4	2.7	2.9	3.0	3.2	2.8	-3.0	3.1
Irritable Bowel Disease (IBD)	0.4	1.1	1.7	0.8	1.0	0.7	1.3	0.9	-1.1	1.2
Ulcerative Colitis (UC)	1.0	1.9	3.0	-1.6	-1.3	-1.7	-1.1	-1.3	1.3	-1.2
Major Depression (MDD)	0.7	0.9	1.4	-0.5	-1.0	-0.7	-0.9	-1.0	1.2	-1.1
Reaction Time	0.7	1.4	1.7	-1.1	-1.3	-1.1	-1.1	-1.2	1.3	-1.3
Verbal and Numeric Reasoning (VNR)	6.5	15.7	16.5	-4.0	-3.9	-3.8	-4.0	-3.9	4.1	-4.1
Breast Cancer	0.0	0.1	0.6	-0.2	0.2	-0.8	-0.1	0.3	-0.1	0.1
Ovarian Cancer	0.3	0.4	1.0	0.7	0.3	1.0	0.9	0.3	-0.4	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	2.6	3.8	4.8	2.2	1.7	2.0	2.1	1.8	-2.0	2.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.4	2.0	2.3	1.5	1.4	1.4	1.0	1.5	-1.4	1.5
Coronary Artery Disease (CAD)	0.6	0.7	1.1	1.1	0.9	0.8	0.6	0.9	-0.9	0.8
Crohns Disease (2012)	6.0	9.7	13.7	2.7	3.0	3.0	3.7	2.9	-3.2	3.2
Mean Putamen Volume	2.4	2.7	3.8	-1.9	-1.8	-1.7	-1.0	-1.9	1.7	-1.4
Fasting Glucose	0.9	1.1	2.2	1.5	1.0	1.3	1.0	0.9	-0.9	0.8
HbA1C	1.9	2.1	2.5	1.4	1.4	1.2	1.5	1.5	-1.5	1.6
HDL Cholesterol	2.7	4.6	5.6	-2.1	-2.4	-1.6	-2.4	-2.3	2.1	-2.0
LDL Cholesterol	0.4	0.6	2.2	0.2	-0.6	-1.1	-1.5	-0.3	0.7	-0.6
Lupus	0.0	0.1	0.1	0.2	-0.2	0.3	-0.1	-0.2	0.3	-0.3
Neuroticism (2016)	0.4	0.6	1.4	-1.2	-0.8	-0.9	-0.8	-0.8	0.3	0.2
Primary Biliary Cirrhosis	1.1	1.6	2.0	1.4	1.2	1.2	1.1	1.1	-1.4	1.4
Rheumatoid Arthritis	0.2	0.2	0.4	0.7	0.5	0.2	0.3	0.6	-0.4	0.5
Schizophrenia (2014)	2.9	6.3	10.3	-2.1	-2.4	-3.2	-2.7	-2.3	2.7	-2.0
Triglycerides	3.1	5.0	7.2	2.7	2.2	1.7	2.4	2.4	-2.0	2.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.1	0.9	0.8	0.1	0.3	1.1	-0.9	1.1
Ulcerative Colitis	1.0	1.5	2.7	-1.1	-1.2	-1.6	-0.9	-1.2	1.3	-1.2
Blood Eosinophil Count	0.1	0.9	1.4	1.1	1.1	0.7	0.7	1.2	-1.0	0.8
Blood Platelet Count	0.7	8.1	19.6	-1.9	-2.4	-2.8	-4.4	-2.3	2.6	-2.6
Blood Red Count	4.0	38.9	47.1	5.5	6.1	6.6	6.9	6.1	-6.4	6.1
Blood White Count	0.5	3.6	6.7	2.6	2.2	1.2	0.6	2.2	-1.6	2.1
Heel T-Score	0.1	1.0	1.5	0.7	1.1	0.8	0.8	1.1	-1.2	1.2
BMI	0.4	2.1	3.2	1.4	1.5	1.3	1.8	1.4	-1.2	1.4
Height	0.7	13.2	15.3	-3.6	-3.6	-3.9	-3.4	-3.6	3.8	-3.5
Waist Hip Ratio (WHR)	0.9	4.2	6.6	2.1	1.9	2.1	2.6	1.9	-1.9	1.7
Systolic Blood Pressure	2.6	13.1	18.0	4.2	3.6	3.3	2.8	3.5	-4.0	3.7
Smoking Status	1.9	4.5	4.9	-1.9	-2.2	-2.1	-2.2	-2.2	2.2	-2.1
Allergy or Eczema	1.7	4.4	5.5	2.1	2.3	1.6	1.5	2.3	-2.3	2.3
Cardiovascular Disease	2.9	9.5	10.0	3.0	3.2	3.1	3.0	3.2	-3.1	3.0
Hypothyroidism (self reported)	0.2	0.4	2.6	0.6	0.1	-0.1	-1.6	0.1	0.0	-0.1
Respiratory disease	9.8	21.9	24.4	4.9	4.7	4.4	4.6	4.8	-4.8	4.4
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	0.5	0.8	0.3	0.7	0.8	-0.7	0.7
Lung FEV1/FVC ratio	3.8	19.1	25.4	-5.0	-4.3	-4.0	-4.4	-4.3	4.2	-4.3
Lung FVC	1.7	8.4	9.7	-3.1	-2.9	-2.4	-3.1	-2.9	3.0	-2.9
Neuroticism	1.7	4.2	4.8	-2.1	-2.2	-1.6	-2.1	-2.1	1.9	-2.2
Chronotype (morning person)	10.8	24.9	28.5	-5.1	-4.9	-4.8	-5.3	-4.8	5.0	-5.0
Hair Pigment	0.0	0.3	0.8	0.1	-0.3	-0.9	-0.6	-0.3	0.5	-0.6
Tanning	0.1	1.3	3.2	-1.0	-1.0	-0.7	-1.8	-1.0	1.0	-1.1
Hand grip strength (left)	5.0	13.3	14.4	-3.8	-3.6	-3.8	-3.7	-3.6	3.8	-3.4
Number of treatments/medications taken	5.0	8.9	11.5	3.0	3.0	2.9	2.4	3.0	-3.4	3.1
Average weekly spirits intake	0.1	0.1	0.5	0.0	-0.1	-0.6	-0.7	-0.0	0.0	0.1
Sensitivity / hurt feelings	2.7	4.7	6.1	-2.0	-2.3	-1.7	-2.5	-2.3	2.0	-2.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.0	-1.0	-0.8	-0.9	-0.6	-0.8	0.6	-0.7
Hearing difficulty/problems: Yes	2.0	3.0	3.7	-1.8	-1.6	-1.7	-1.9	-1.6	1.7	-1.7
Relative age of first facial hair	1.8	3.7	4.8	-2.2	-2.0	-1.6	-1.8	-1.9	1.9	-1.9
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	2.9	1.7	1.3	1.5	0.8	1.4	-1.5	1.5
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.3	-1.1	-1.1	-1.1	-0.8	-1.1	1.0	-1.0
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	0.8	0.7	-0.2	0.4	0.7	-0.3	0.8
Systolic blood pressure, automated reading	1.2	3.6	5.0	2.0	1.9	1.7	1.5	1.8	-2.2	2.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.1	0.8	0.6	0.1	0.8	-0.4	0.5
Angina	1.1	1.4	2.2	1.5	1.3	0.6	1.0	1.3	-1.1	1.4
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.1	-0.4	-0.3	-0.3	-0.5	0.1	-0.3
Vitamin and mineral supplements	0.7	0.9	1.9	1.0	0.9	0.3	1.4	1.0	-1.0	0.8
Supplements: Zinc	0.4	0.4	0.7	-0.7	-0.6	0.1	-0.8	-0.6	0.5	-0.8
Medication: Co-codamol	0.3	0.3	0.6	-0.5	-0.6	-0.2	-0.1	-0.6	0.6	-0.8
Medication: Metformin	0.0	0.0	0.1	-0.2	0.3	0.3	0.0	0.3	-0.1	0.0
Diabetes (father)	1.2	1.4	2.1	1.3	1.2	1.2	1.4	1.2	-1.1	0.9
Diabetes (mother)	2.1	2.6	3.3	-1.8	-1.6	-1.4	-1.6	-1.6	1.8	-1.6
Severe depression (siblings)	1.9	2.2	3.5	-1.6	-1.4	-1.1	-1.9	-1.4	1.4	-1.4
Pack years adult smoking proportion	0.1	0.1	0.3	0.5	0.3	0.2	-0.4	0.3	-0.3	0.3
Impedance of leg (right)	0.0	0.2	0.3	-0.4	-0.5	-0.3	-0.5	-0.5	0.3	-0.5
Leg fat-free mass (left)	0.1	0.4	1.0	-0.2	-0.5	-1.0	-0.4	-0.6	0.7	-0.5
Trunk fat percentage	0.6	2.3	4.7	2.2	1.4	1.6	1.3	1.4	-1.4	1.2
Hand grip strength (right)	4.5	12.2	13.6	-3.3	-3.5	-3.5	-3.4	-3.6	3.7	-3.4
Townsend deprivation index at recruitment	1.6	2.2	2.9	-1.4	-1.5	-1.2	-1.7	-1.4	1.7	-1.5
Current tobacco smoking	0.8	1.3	2.0	-0.6	-1.3	-0.4	-1.4	-1.3	1.4	-1.2
Average weekly fortified wine intake	0.5	0.6	1.6	-0.5	-0.5	-1.2	-1.3	-0.5	0.2	-0.1
Maternal smoking around birth	0.7	1.0	2.6	1.6	1.0	0.6	0.7	1.1	-0.7	0.8
Fed-up feelings	0.1	0.2	0.7	-0.6	-0.3	-0.9	0.1	-0.2	0.2	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	0.9	-0.8	-0.8	-0.9	-0.6	-0.9	0.8	-1.0
Relative age voice broke	2.1	3.2	4.5	-1.9	-1.8	-1.2	-2.1	-1.7	1.7	-1.9
Taking other prescription medications	2.3	3.5	4.7	2.0	2.0	1.4	1.5	2.0	-2.2	2.0
Age when periods started (menarche)	5.9	14.1	16.2	-3.9	-3.9	-3.2	-3.7	-3.9	3.7	-4.0
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.5	0.4	-0.2	0.2	0.4	-0.2	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.1	0.3	1.0	0.8	1.4	1.0	-0.9	1.0
Tinnitus: Yes, but not now, but have in the past	5.5	5.9	7.1	2.4	2.6	2.1	2.1	2.5	-2.5	2.7
Qualifications: CSEs or equivalent	0.3	0.4	0.9	0.9	0.4	0.9	0.6	0.4	-0.4	0.3
Serious illness, injury or assault to yourself	3.2	3.8	4.8	2.2	2.0	1.9	1.6	2.0	-2.1	1.8
High blood pressure	0.8	2.1	2.9	1.2	1.4	1.7	1.6	1.4	-1.5	1.3
Hayfever, allergic rhinitis or eczema	1.4	3.1	3.9	1.6	2.0	1.3	1.4	2.0	-2.0	2.0
Multivitamins +/- minerals	0.9	1.1	1.9	-1.1	-1.0	-0.6	-1.4	-1.0	1.1	-1.1
Stomach or abdominal pain in last month	3.5	4.3	6.1	2.4	2.1	1.4	1.8	2.1	-2.5	2.1
Supplements: Glucosamine	2.1	2.8	3.6	1.5	1.7	1.3	1.9	1.6	-1.7	1.9
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	3.3	1.1	1.3	1.3	1.8	1.4	-1.6	1.3
Medication: Atenolol	0.4	0.5	0.9	1.0	0.6	0.0	0.6	0.6	-0.7	0.8
Medication: Levothyroxine sodium	0.4	0.7	1.8	-0.4	-0.7	-0.7	-1.3	-0.7	0.7	-0.9
Sitting height	0.4	2.5	3.3	-1.8	-1.5	-1.8	-1.2	-1.6	1.4	-1.6
Chronic bronchitis/emphysema (father)	2.2	2.6	3.3	-1.5	-1.8	-1.3	-1.1	-1.8	1.7	-1.8
High blood pressure (mother)	4.4	6.1	8.5	2.9	2.5	2.5	2.0	2.4	-2.4	2.5
Body mass index (BMI)	0.1	0.3	0.8	0.9	0.5	0.5	0.5	0.4	-0.4	0.5
Impedance of leg (left)	0.0	0.0	0.1	-0.3	-0.1	-0.0	-0.2	-0.1	-0.1	-0.3
Leg predicted mass (left)	0.1	0.3	0.9	-0.1	-0.4	-0.9	-0.3	-0.5	0.6	-0.4
Trunk fat mass	0.1	0.6	1.7	1.3	0.6	0.7	0.6	0.6	-0.6	0.5
Waist circumference	0.0	0.1	0.4	0.7	0.3	0.3	0.5	0.2	-0.2	0.2
Number of incorrect matches in round	1.2	2.0	2.7	1.5	1.4	1.1	1.1	1.5	-1.7	1.6
Past tobacco smoking	3.0	5.6	6.2	2.3	2.5	2.4	2.3	2.5	-2.3	2.4
Alcohol usually taken with meals	0.0	0.0	0.1	-0.0	0.1	0.0	0.3	0.2	-0.1	0.4
Nervous feelings	0.9	1.7	2.2	-1.2	-1.3	-1.0	-1.4	-1.3	1.2	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.4	0.0	-0.4	-0.6	-0.2	-0.4	0.1	-0.4
Hearing difficulty/problems with background noise	3.8	6.1	10.0	-2.4	-2.3	-3.2	-2.3	-2.3	2.3	-2.3
Hair/balding pattern: Pattern 2	0.0	0.0	0.2	0.1	0.1	-0.5	0.1	0.1	-0.2	0.0
Had menopause	0.9	1.2	2.4	-1.2	-0.9	-1.5	-0.9	-0.9	1.1	-0.9
Had other major operations	9.2	11.2	12.7	3.5	3.4	2.7	3.4	3.4	-3.4	3.6
Forced vital capacity (FVC)	0.7	2.6	4.1	-1.5	-1.5	-1.4	-2.0	-1.5	1.7	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	0.2	0.7	0.9	0.6	0.7	-0.6	0.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.0	0.8	1.0	0.3	0.9	1.0	-1.0	0.7
Qualifications: None of the above	0.4	0.8	2.0	1.4	0.9	0.7	0.6	1.0	-0.7	0.8
Financial difficulties in last 2 years	4.8	6.4	7.5	2.5	2.7	2.2	2.6	2.7	-2.7	2.3
Mouth/teeth dental problems	0.0	0.1	0.3	-0.1	0.1	0.5	-0.2	0.0	-0.1	0.2
Heart attack	0.7	1.0	1.5	0.8	1.2	0.4	0.8	1.2	-1.2	0.9
Allergy	5.3	12.2	13.1	-3.5	-3.6	-3.3	-3.3	-3.6	3.6	-3.6
Pain all over the body in last month	4.1	4.4	5.6	-2.0	-2.2	-1.7	-2.1	-2.2	2.4	-2.2
Diabetes (self-reported)	0.1	0.1	0.3	0.2	0.4	0.4	0.5	0.5	-0.3	0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	0.5	0.7	0.6	0.6	0.7	-0.8	0.6
Medication: Ramipril	0.2	0.2	0.7	0.6	0.1	0.8	0.6	0.1	-0.4	0.3
Medication: Simvastatin	1.4	2.1	2.9	1.5	1.5	1.0	1.3	1.5	-1.7	1.5
Fluid intelligence score	8.5	17.7	20.5	-4.4	-4.3	-3.7	-4.1	-4.3	4.5	-4.3
Illnesses of siblings	0.3	0.5	1.2	0.4	0.6	0.7	1.1	0.6	-0.5	0.7
Neuroticism score	0.8	1.7	2.2	-1.4	-1.4	-1.2	-1.2	-1.4	1.1	-1.5
Weight	0.0	0.1	0.2	0.2	-0.2	-0.5	-0.1	-0.3	0.3	-0.2
Impedance of arm (right)	2.0	9.5	12.3	3.5	3.1	2.8	2.8	3.1	-3.3	3.0
Arm fat percentage (right)	0.9	3.6	6.6	2.6	1.8	1.9	1.7	1.7	-1.8	1.8
Trunk fat-free mass	0.6	3.7	6.2	-1.9	-1.8	-2.5	-1.6	-1.9	1.9	-1.6
Hip circumference	0.0	0.0	0.1	0.2	-0.2	-0.3	-0.1	-0.2	0.2	-0.2
Time employed in main current job	2.5	2.9	4.3	1.2	1.9	1.0	2.1	1.8	-1.7	2.0
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.3	0.5	-0.3	0.5	0.5	-0.3	0.6
Father’s age at death	0.2	0.3	0.8	-0.7	-0.7	-0.1	-0.2	-0.9	0.5	-0.2
Worrier / anxious feelings	0.1	0.2	0.8	0.5	0.3	0.9	0.3	0.4	-0.3	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.6	-0.8	-0.5	-0.8	-0.8	-0.5	0.4	-0.7
Falls in the last year	0.2	0.3	0.9	0.6	-0.5	-0.6	-0.9	-0.3	0.3	-0.6
Hair/balding pattern: Pattern 3	0.8	1.2	1.8	-1.3	-1.1	-0.9	-1.3	-1.0	1.2	-1.0
Number of live births	1.0	1.4	1.8	-1.1	-1.2	-1.2	-1.0	-1.2	1.3	-1.2
Forced expiratory volume in 1-second (FEV1)	1.7	5.8	6.8	-2.6	-2.3	-2.2	-2.6	-2.4	2.5	-2.3
Pulse rate	0.3	0.5	1.2	0.7	0.7	0.2	1.1	0.7	-0.5	0.7
Happiness	1.2	1.5	3.0	-1.7	-1.0	-1.6	-0.7	-1.0	0.8	-1.2
Noisy workplace	0.2	0.3	1.0	-1.0	-0.5	-0.1	-0.2	-0.4	0.5	-0.5
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.5	-1.6	-1.3	-1.2	-0.8	-1.4	1.1	-1.0
Serious illness, injury or assault of a close relative in last 2 years	3.0	3.5	5.1	1.7	2.2	1.7	1.6	2.3	-1.8	1.8
Mouth/teeth dental problems: Dentures	0.9	1.5	2.2	-1.5	-1.3	-1.2	-1.1	-1.2	1.1	-1.1
Asthma	10.1	19.8	22.0	4.5	4.6	4.2	4.3	4.7	-4.6	4.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.4	-0.2	0.3	-0.6	-0.2	-0.2	-0.1
Medication: Cholesterol lowering	0.9	1.3	2.1	1.0	1.1	1.3	0.9	1.1	-1.1	1.4
Depression (self-reported)	0.7	0.9	1.9	1.4	0.9	0.5	0.8	0.9	-1.0	0.8
Medication: Lansoprazole	0.8	1.0	1.5	1.2	1.1	0.8	0.8	1.1	-0.8	0.9
Prospective memory result	1.0	1.2	1.6	1.1	1.0	1.3	1.2	1.0	-1.0	1.1
Lung cancer (father)	1.7	2.0	2.3	-1.4	-1.5	-1.2	-1.4	-1.5	1.4	-1.5
Illnesses of mother	0.3	0.4	0.8	-0.9	-0.7	-0.2	0.0	-0.8	0.7	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.6	7.9	-2.8	-2.5	-2.2	-2.6	-2.5	2.8	-2.6
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.5	0.1	0.3	0.2	0.2	-0.5	0.3
Impedance of arm (left)	2.5	11.4	14.2	3.8	3.3	3.3	3.1	3.3	-3.6	3.2
Arm fat mass (right)	0.3	1.1	2.5	1.6	1.0	0.9	1.0	0.9	-0.9	0.9
Trunk predicted mass	0.7	3.8	6.2	-1.9	-1.9	-2.5	-1.6	-1.9	2.0	-1.7
Standing height	0.2	1.7	3.7	-1.3	-1.3	-1.9	-0.9	-1.3	1.2	-1.1
Length of working week for main job	4.9	5.5	6.3	2.3	2.5	2.1	2.3	2.5	-2.2	2.4
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.4	0.5	0.7	0.3	0.6	-0.5	0.3
Breastfed as a baby	5.0	6.2	7.7	-2.8	-2.5	-2.5	-2.2	-2.5	2.5	-2.5
Tense / ‘highly strung’	0.1	0.1	0.4	-0.6	-0.1	-0.4	0.6	0.0	-0.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.3	-0.1	-0.9	-1.1	-0.6	-1.0	0.9	-1.1
Hair/balding pattern: Pattern 4	4.9	11.8	14.1	3.8	3.6	3.0	3.2	3.5	-3.5	3.5
Birth weight of first child	1.0	1.9	3.0	-1.7	-1.4	-0.9	-0.9	-1.4	1.3	-1.7
Peak expiratory flow (PEF)	0.4	0.8	1.3	0.6	0.9	1.0	0.9	0.8	-0.9	1.1
Pulse wave reflection index	0.1	0.1	0.4	0.3	0.0	0.6	-0.2	0.0	-0.3	-0.1
Ever highly irritable/argumentative for 2 days	0.5	0.7	0.9	0.5	0.9	-0.7	0.7	0.9	-0.8	0.9
Loud music exposure frequency	0.5	0.6	1.3	1.2	0.8	0.5	-0.0	0.8	-0.7	0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	0.9	-0.9	-0.9	-0.3	-0.7	-0.9	0.8	-0.8
Mouth/teeth dental problems: Bleeding gums	3.1	4.0	5.1	2.1	1.8	2.1	2.2	1.9	-1.9	1.8
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.1	-0.4	0.0	-0.3	-0.4	0.3	-0.2
Medication: Paracetamol	1.4	2.4	3.3	1.8	1.5	1.6	1.4	1.4	-1.5	1.5
Headache pain in last month	0.1	0.1	0.2	0.2	-0.2	0.4	0.5	-0.1	0.3	-0.4
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.2	0.0	0.3	0.1	0.4	0.4	-0.3	0.0
Glaucoma (self-reported)	3.5	4.1	4.4	1.9	2.1	2.1	2.0	2.1	-2.1	2.0
Gout (self-reported)	0.2	0.3	1.1	0.2	-0.3	0.4	-1.1	-0.2	0.2	-0.5
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	6.2	-0.9	-1.3	-1.1	-2.5	-1.3	1.3	-1.6
Medication: Amlodipine	0.7	1.0	1.4	-1.0	-1.1	-1.2	-0.9	-1.0	1.1	-0.9
Medication: Ventolin 100micrograms inhaler	5.5	7.0	8.8	2.6	2.7	2.2	2.6	2.7	-3.0	2.7
Birth weight	1.3	2.8	3.8	-1.3	-1.7	-1.9	-1.6	-1.7	1.7	-1.6
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.0	1.7	1.2	1.3	1.0	1.2	-1.1	1.0
High blood pressure (siblings)	0.4	0.6	0.7	0.8	0.8	0.7	0.3	0.8	-0.9	0.7
Forced vital capacity (FVC), Best measure	1.1	4.0	5.1	-1.9	-2.0	-1.8	-2.0	-1.9	2.3	-2.0
Body fat percentage	0.4	1.6	3.5	1.9	1.1	1.4	1.0	1.1	-1.1	1.0
Leg fat percentage (right)	0.1	0.2	0.3	0.0	-0.5	-0.2	-0.5	-0.5	0.5	-0.5
Arm fat-free mass (right)	0.7	3.8	5.4	-1.9	-1.9	-2.3	-1.6	-1.9	2.1	-1.8
Exposure to tobacco smoke outside home	1.0	1.3	2.2	-0.8	-1.1	-0.5	-1.4	-1.2	1.5	-1.2
Comparative body size at age 10	0.6	1.7	3.5	1.9	1.3	0.9	0.7	1.3	-1.3	1.4
Number of full brothers	0.7	0.8	1.3	-0.7	-0.9	-0.6	-0.9	-1.0	1.1	-1.1
Worry too long after embarrassment	0.4	0.6	1.3	-0.8	-0.7	-0.8	-1.1	-0.7	0.4	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.7	0.2	-0.1	0.7	0.2	-0.2	0.0
Wheeze or whistling in the chest in last year	6.2	11.0	13.4	3.6	3.4	2.9	2.9	3.4	-3.7	3.3
Number of children fathered	0.5	0.6	1.9	0.9	0.4	1.4	0.8	0.3	-0.4	0.4
Reason for reducing amount of alcohol drunk: Health precaution	10.5	12.2	14.1	-3.8	-3.6	-3.6	-3.2	-3.5	3.6	-3.3
Age at first live birth	0.8	1.5	2.1	1.3	1.3	0.9	0.8	1.3	-1.5	1.4
Pulse wave peak to peak time	0.4	0.4	0.7	-0.7	-0.5	-0.7	-0.5	-0.5	0.8	-0.6
Health satisfaction	0.0	0.0	0.0	-0.2	0.1	0.1	0.1	0.0	-0.2	-0.2
Shortness of breath walking on level ground	1.4	1.7	2.1	1.3	1.3	1.0	1.3	1.4	-1.3	1.2
Qualifications: College or University degree	0.1	0.3	1.0	-1.0	-0.3	-1.0	-0.2	-0.3	0.4	-0.2
Eye problems/disorders: None of the above	0.7	0.8	1.2	1.0	0.7	0.9	1.1	0.6	-0.9	0.9
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.9	-0.9	-1.2	-1.7	-0.8	-1.2	1.2	-1.1
Emphysema/chronic bronchitis	6.0	6.7	10.0	3.2	2.6	2.4	2.2	2.7	-2.5	2.5
Medication for pain relief, constipation, heartburn	0.6	1.0	1.9	-1.4	-0.8	-1.2	-0.5	-0.8	0.8	-1.0
Neck or shoulder pain in last month	0.1	0.2	0.8	0.7	0.0	0.9	-0.1	0.1	-0.3	0.1
Medication: Blood pressure	0.5	0.8	1.2	-0.5	-1.0	-0.9	-1.1	-1.0	0.9	-0.9
Angina (self-reported)	1.0	1.3	2.0	1.4	1.2	0.6	0.9	1.2	-1.0	1.4
Migraine (self-reported)	0.6	0.7	0.9	0.9	0.9	0.5	1.0	1.0	-0.6	0.8
Medication: Ibuprofen	0.5	0.6	1.2	1.1	0.5	0.9	0.0	0.5	-1.0	0.7
Medication: Allopurinol	0.5	0.7	1.7	-0.6	-0.8	-0.2	-1.3	-0.8	0.7	-0.9
Medication: Omeprazole	0.3	0.3	1.5	1.2	0.4	0.5	0.0	0.3	-0.3	0.2
Medication: Seretide 50 evohaler	0.1	0.1	0.6	0.2	0.0	-0.5	-0.8	0.0	0.1	0.0
Mean time to correctly identify matches	1.1	2.1	2.4	-1.2	-1.5	-1.5	-1.4	-1.5	1.5	-1.4
Heart disease (mother)	0.1	0.2	0.3	0.6	0.5	0.2	0.4	0.5	-0.4	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.3	0.5	0.8	0.6	0.4	0.8	-1.1	0.9
Whole body fat mass	0.1	0.4	1.4	1.2	0.5	0.6	0.5	0.4	-0.4	0.4
Leg fat mass (right)	0.1	0.3	0.5	-0.1	-0.6	-0.5	-0.5	-0.7	0.7	-0.6
Arm predicted mass (right)	0.9	4.5	6.0	-2.1	-2.1	-2.4	-1.8	-2.1	2.2	-2.0
Pulse rate, automated reading	0.0	0.1	0.2	0.1	-0.0	0.2	0.4	-0.0	0.3	-0.3
Alcohol intake frequency.	0.7	1.7	2.0	-1.3	-1.4	-1.1	-1.3	-1.4	1.4	-1.2
Comparative height size at age 10	0.7	3.9	7.0	2.6	2.0	1.0	1.9	2.0	-1.9	2.0
Number of full sisters	1.4	1.7	2.8	-0.6	-1.3	-0.8	-1.7	-1.3	1.4	-1.6
Suffer from ‘nerves’	0.4	0.7	1.3	1.1	0.5	1.0	0.6	0.5	-1.0	0.6
Overall health rating	0.1	0.1	0.5	0.7	0.0	-0.1	0.5	0.0	0.0	-0.2
Chest pain or discomfort	0.3	0.5	1.6	1.3	0.7	0.1	0.6	0.7	-0.6	0.3
Had major operations	1.1	1.3	1.9	-0.8	-1.3	-0.8	-0.7	-1.4	1.3	-1.3
Age at last live birth	0.0	0.1	0.3	0.6	0.2	0.2	-0.1	0.2	-0.2	0.1
Family relationship satisfaction	0.3	0.3	1.0	-1.0	-0.4	-0.7	-0.4	-0.4	0.4	-0.5
Leg pain on walking	0.1	0.2	0.4	-0.2	-0.4	-0.0	-0.6	-0.4	0.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	3.8	1.5	1.3	1.9	1.5	1.2	-1.8	1.5
Commuting to job workplace: Car/motor vehicle	3.3	3.8	5.7	2.4	1.9	2.1	1.5	1.9	-2.0	1.7
Illness, injury, bereavement, stress in last 2 years	3.3	4.0	4.8	-1.9	-2.0	-1.8	-2.2	-2.0	2.1	-1.9
Medication: Aspirin	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	0.1	0.2	0.3
Supplements: Vitamin C	0.1	0.1	0.2	0.5	0.1	0.5	0.3	0.1	-0.2	0.3
Knee pain experienced in last month	3.8	5.8	7.5	2.7	2.4	1.8	2.7	2.4	-2.3	2.5
Hypertension (Self-reported)	0.8	2.2	3.4	1.3	1.4	1.9	1.6	1.4	-1.5	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.3	0.8	1.1	1.0	0.9	1.1	-0.8	1.0
Illnesses of father: Heart disease	3.0	4.2	5.5	1.7	2.3	1.6	1.8	2.3	-2.3	2.2
Illnesses of siblings: Diabetes	3.9	4.8	6.6	2.6	2.3	1.9	2.1	2.3	-2.2	2.1
Smoking status: Previous	1.6	2.4	4.5	-1.6	-1.4	-2.1	-1.3	-1.4	1.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	4.0	1.8	1.4	1.2	2.0	1.4	-1.2	1.3
Whole body fat-free mass	0.3	1.9	3.6	-1.2	-1.3	-1.9	-1.1	-1.3	1.4	-1.2
Leg fat-free mass (right)	0.0	0.1	0.5	0.1	-0.1	-0.7	0.0	-0.1	0.3	-0.1
Arm fat percentage (left)	1.1	4.5	8.0	2.8	2.0	2.1	1.9	1.9	-2.0	1.9
Average weekly red wine intake	0.0	0.0	0.1	-0.0	0.0	0.1	-0.0	0.0	-0.2	-0.0
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.0	-0.1	-0.3	0.0	-0.2	0.2	0.0
Mood swings	0.2	0.4	0.8	-0.9	-0.7	-0.9	-0.3	-0.6	0.5	-0.6
Loneliness, isolation	1.0	1.4	2.0	1.1	1.0	1.4	1.2	1.0	-1.4	0.9
Long-standing illness, disability or infirmity	0.6	0.9	1.4	1.2	0.9	0.7	0.8	0.9	-1.0	0.9
Ever had bowel cancer screening	0.1	0.1	0.1	-0.3	-0.2	-0.4	-0.4	-0.2	0.0	0.1
Diabetes diagnosed by doctor	0.0	0.0	0.1	-0.1	0.2	0.1	0.3	0.2	-0.1	0.0
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	2.8	-1.7	-1.4	-1.1	-1.4	-1.5	1.4	-1.7
Friendships satisfaction	1.7	2.1	3.8	-1.9	-1.3	-1.6	-1.4	-1.3	1.2	-1.3
Qualifications: nursing, teaching	1.7	2.6	3.2	1.7	1.5	1.5	1.8	1.5	-1.6	1.7
Commuting to job workplace: Walk	0.7	0.7	1.2	-0.7	-0.8	-0.9	-1.1	-0.8	0.9	-0.7
Eye problems/disorders: Cataract	5.8	6.7	9.2	-2.4	-2.5	-2.1	-3.0	-2.5	2.8	-2.6
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	2.9	1.7	1.4	0.8	1.2	1.5	-1.3	1.3
Medication for cholesterol	1.1	1.7	2.4	-1.4	-1.1	-1.5	-1.3	-1.1	1.4	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	1.9	2.4	1.3	1.5	1.4	1.2	1.4	-1.4	1.6
Back pain experienced in last month	0.3	0.5	1.1	-0.8	-0.6	-1.0	0.1	-0.6	0.7	-0.7
Mineral and other dietary supplements	0.3	0.4	0.7	-0.7	-0.6	-0.7	-0.2	-0.6	0.8	-0.8
Breast cancer (self-reported)	0.8	1.0	1.6	0.9	0.9	1.3	1.0	0.9	-1.1	0.8
Asthma (self-reported)	10.0	20.0	21.8	4.5	4.6	4.3	4.3	4.7	-4.7	4.3
Osteoporosis (self-reported)	0.4	0.6	1.0	-0.6	-1.0	-0.3	-0.8	-1.0	0.6	-0.8
Osteoarthritis (self-reported)	0.5	0.6	1.4	0.7	0.6	0.9	1.2	0.5	-0.6	0.7
Medication: Aspirin	0.1	0.1	0.2	0.2	0.3	0.3	-0.2	0.3	-0.0	0.4
Medication: Gliclazide	2.4	2.8	5.2	1.3	1.7	2.3	1.4	1.7	-1.5	1.5
Illnesses of father: None of the above (group 1)	0.7	0.9	1.0	-1.0	-1.0	-0.9	-0.9	-1.0	0.8	-0.9
Smoking status: Current	0.8	1.3	2.0	-0.6	-1.3	-0.4	-1.4	-1.3	1.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	2.6	-1.6	-1.4	-1.4	-1.2	-1.3	1.4	-1.4
Whole body water mass	0.4	2.2	4.0	-1.4	-1.4	-2.0	-1.2	-1.4	1.5	-1.3
Leg predicted mass (right)	0.0	0.1	0.5	0.0	-0.1	-0.7	-0.0	-0.2	0.3	-0.2
Arm fat mass (left)	0.3	1.2	2.6	1.6	1.0	1.0	1.1	0.9	-1.0	1.0
Number of self-reported non-cancer illnesses	1.3	2.3	2.9	1.4	1.5	1.6	1.3	1.5	-1.7	1.6
Average weekly champagne plus white wine intake	3.7	5.1	7.5	1.9	2.2	1.9	2.1	2.1	-2.7	2.7
Miserableness	0.2	0.3	0.6	-0.8	-0.4	-0.7	-0.5	-0.4	0.3	-0.5
Guilty feelings	2.5	3.8	5.5	-1.7	-1.9	-2.0	-2.3	-1.9	1.9	-1.9
Wears glasses or contact lenses	1.6	1.8	3.2	-1.7	-1.2	-1.8	-0.9	-1.2	1.3	-1.1
Ever taken oral contraceptive pill	1.2	1.3	1.7	1.1	1.2	0.8	1.1	1.2	-1.3	1.3
Hearing aid user	0.3	0.3	0.5	-0.2	0.7	-0.5	0.4	0.7	-0.5	0.7
Mother’s age at death	0.9	1.1	1.8	-1.3	-1.0	-1.0	-1.2	-0.9	0.8	-1.0
Financial situation satisfaction	0.5	0.6	1.5	0.5	0.8	0.8	1.2	0.7	-0.8	0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.2	0.2	0.4	-0.2	0.3	-0.3	0.3
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.5	0.1	-0.5	0.2	0.1	-0.0	-0.0
Eye problems/disorders: Glaucoma	0.9	1.0	1.4	0.9	1.1	0.9	1.0	1.1	-1.2	0.9
Medication: Blood pressure	0.9	1.7	3.3	1.1	1.1	1.8	1.3	1.1	-1.4	1.1
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.3	1.0	0.8	1.3	1.5	0.7	-0.9	0.8
Supplements: Fish oil (including cod liver oil)	1.7	2.2	3.0	1.7	1.5	1.4	1.1	1.5	-1.7	1.6
High cholesterol (Self-reported)	4.2	7.4	9.0	2.8	2.7	3.0	2.3	2.6	-2.8	2.7
Medication: Bendroflumethiazide	0.1	0.2	0.3	-0.3	-0.4	0.6	-0.0	-0.4	0.6	-0.5
Medication: Paracetamol	2.7	4.1	5.4	2.3	2.0	2.1	1.9	1.9	-2.0	1.9
Medication: Lisinopril	0.6	0.7	1.3	-1.0	-0.8	-0.7	-1.1	-0.9	0.4	-0.9
Medication: Atorvastatin	2.5	3.1	4.2	2.0	1.7	2.0	1.4	1.7	-1.7	1.8
Illnesses of father: High blood pressure	1.5	1.9	2.6	1.2	1.5	1.1	1.5	1.4	-1.2	1.6
Alcohol drinker status: Never	3.4	4.1	4.8	-1.8	-2.1	-1.9	-2.0	-2.1	2.2	-1.9
Ever smoked	3.2	5.6	6.3	-2.2	-2.5	-1.9	-2.5	-2.5	2.4	-2.5
Basal metabolic rate	0.2	1.1	2.3	-0.8	-1.0	-1.5	-0.8	-1.0	1.1	-0.9
Leg fat percentage (left)	0.0	0.0	0.1	0.3	-0.1	0.1	-0.2	-0.1	0.1	-0.2
Arm fat-free mass (left)	0.8	4.1	5.3	-1.9	-2.0	-2.3	-1.7	-2.0	2.2	-1.9
Number of operations (self-reported)	1.0	1.5	2.9	1.7	1.1	0.9	1.2	1.1	-1.0	1.2
Average weekly beer plus cider intake	0.6	0.8	1.8	-0.7	-0.8	-1.4	-0.4	-0.8	0.9	-1.1
Irritability	0.2	0.4	2.0	-0.6	-0.3	-1.4	0.2	-0.3	-0.0	-0.1
Risk taking	0.9	1.3	1.8	-1.2	-1.3	-0.8	-1.2	-1.3	1.1	-1.2
Ever had prostate specific antigen (PSA) test	1.9	2.2	2.9	-1.5	-1.7	-1.0	-1.6	-1.6	1.4	-1.5
Fractured/broken bones in last 5 years	0.0	0.0	0.2	-0.2	-0.1	-0.4	-0.2	-0.1	0.0	0.2
Age started oral contraceptive pill	2.3	2.9	4.3	1.1	1.7	1.0	2.1	1.8	-1.8	2.1
Diastolic blood pressure, automated reading	0.6	1.8	2.3	1.4	1.3	1.5	1.4	1.2	-1.2	1.3
Ever depressed for a whole week	0.2	0.2	1.1	0.5	-0.1	-1.0	-0.3	-0.1	0.4	-0.3
Unable to work because of sickness or disability	1.9	2.5	4.0	1.7	1.6	1.0	2.0	1.6	-1.6	1.4
Commuting to job workplace: Cycle	7.0	8.4	10.3	-3.2	-3.0	-2.8	-2.4	-3.0	3.0	-2.8
Myopia	1.1	1.6	2.4	-0.9	-1.2	-1.5	-1.5	-1.2	1.3	-1.2
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.0	-0.8	-0.8	-1.0	-1.0	-0.8	0.9	-0.8
Cholesterol lowering medication	2.4	3.5	4.5	2.1	1.8	1.8	1.8	1.8	-2.1	1.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.3	1.2	0.4	0.8	0.1	0.3	-0.3	0.2
Pain experienced in last month	0.1	0.2	0.3	0.2	0.5	0.6	0.1	0.5	-0.5	0.4
Supplements: Calcium	0.9	1.0	1.5	-1.1	-1.2	-0.7	-0.6	-1.2	1.0	-1.2
Basal cell carcinoma (self-reported)	0.4	0.5	1.3	-0.7	-0.7	-1.1	-0.1	-0.8	0.4	-0.5
Heart attack/myocardial infarction (self-reported)	1.2	1.5	2.2	1.1	1.5	0.7	1.0	1.5	-1.5	1.2
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.1	0.2	-0.3	0.3	-0.3	-0.3	0.2	-0.1
Heart disease (siblings)	3.8	4.7	5.5	-1.9	-2.1	-2.2	-2.3	-2.1	2.3	-2.3
Alcohol drinker status: Previous	1.9	2.1	2.7	-1.6	-1.5	-1.2	-1.4	-1.6	1.4	-1.4
Pack years of smoking	0.1	0.1	0.3	0.4	0.3	0.0	-0.6	0.3	-0.2	0.3
Impedance of whole body	0.8	4.0	5.0	2.2	2.0	2.1	1.8	1.9	-2.2	1.8
Leg fat mass (left)	0.0	0.2	0.2	-0.0	-0.4	-0.4	-0.3	-0.5	0.5	-0.5
Arm predicted mass (left)	0.8	4.2	5.3	-2.0	-2.0	-2.3	-1.7	-2.1	2.2	-1.9