Hub : Genes

RP11-301O19.1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1350 0.0450 1.7e-07 0.120 NA 0.106 NA 0.123 5.2e-10 NA 6.0e-09 NA 2.9e-10
2 GTEx Adipose Visceral Omentum 0.2370 0.0660 2.5e-09 0.214 NA 0.206 NA 0.041 2.4e-11 NA 5.9e-11 NA 3.4e-03
3 GTEx Artery Aorta 0.0890 0.0350 2.3e-04 0.049 NA 0.046 NA 0.050 1.1e-03 NA 1.4e-03 NA 9.1e-04
4 GTEx Artery Coronary 0.1400 0.0580 1.1e-03 0.159 NA 0.033 NA 0.089 4.9e-06 NA 2.8e-02 NA 6.3e-04
5 GTEx Artery Tibial 0.1003 0.0339 4.0e-06 0.074 NA 0.050 NA 0.023 1.9e-06 NA 8.5e-05 NA 5.9e-03
6 GTEx Brain Caudate basal ganglia 0.2010 0.0740 4.4e-05 0.255 NA 0.142 NA -0.001 5.9e-08 NA 7.2e-05 NA 3.5e-01
7 GTEx Brain Cerebellar Hemisphere 0.1540 0.0730 6.4e-03 0.089 NA 0.043 NA 0.008 2.8e-03 NA 3.0e-02 NA 1.9e-01
8 GTEx Brain Cerebellum 0.1390 0.0640 3.3e-03 0.150 NA 0.103 NA 0.141 3.4e-05 NA 5.9e-04 NA 6.1e-05
9 GTEx Brain Cortex 0.1390 0.0600 3.7e-03 0.233 NA 0.114 NA 0.210 4.2e-07 NA 4.7e-04 NA 1.8e-06
10 GTEx Brain Frontal Cortex BA9 0.1865 0.0753 6.2e-04 0.182 NA 0.173 NA 0.179 1.4e-05 NA 2.4e-05 NA 1.7e-05
11 GTEx Brain Hippocampus 0.1369 0.0640 7.9e-03 0.108 NA 0.037 NA 0.076 1.7e-03 NA 4.9e-02 NA 7.8e-03
12 GTEx Brain Hypothalamus 0.3950 0.0880 4.8e-08 0.374 NA 0.194 NA 0.408 1.0e-09 NA 2.6e-05 NA 1.1e-10
13 GTEx Brain Nucleus accumbens basal ganglia 0.3530 0.0860 6.3e-08 0.403 NA 0.382 NA 0.396 6.5e-12 NA 3.1e-11 NA 1.2e-11
14 GTEx Breast Mammary Tissue 0.2070 0.0710 3.7e-06 0.099 NA 0.102 NA 0.089 9.4e-06 NA 7.0e-06 NA 2.6e-05
15 GTEx Breast Mammary Tissue (Female) 0.2200 0.0956 6.4e-04 0.035 NA 0.067 NA 0.027 3.3e-02 NA 4.7e-03 NA 5.3e-02
16 GTEx Cells Transformed fibroblasts 0.1450 0.0400 3.1e-10 0.214 NA 0.188 NA 0.194 5.2e-16 NA 4.4e-14 NA 1.8e-14
17 GTEx Colon Sigmoid 0.2240 0.0730 2.1e-06 0.169 NA 0.157 NA 0.096 1.4e-06 NA 3.4e-06 NA 2.8e-04
18 GTEx Esophagus Gastroesophageal Junction 0.1750 0.0740 5.9e-04 0.138 NA 0.033 NA -0.007 1.1e-05 NA 2.3e-02 NA 7.6e-01
19 GTEx Esophagus Mucosa 0.0870 0.0320 5.2e-05 0.075 NA 0.054 NA 0.047 9.9e-06 NA 1.8e-04 NA 4.5e-04
20 GTEx Lung 0.0879 0.0321 2.5e-05 0.084 NA 0.094 NA 0.084 5.2e-07 NA 1.1e-07 NA 5.6e-07
21 GTEx Nerve Tibial 0.2278 0.0470 0.0e+00 0.355 NA 0.336 NA 0.352 3.8e-26 NA 1.6e-24 NA 7.2e-26
22 GTEx Pancreas 0.2840 0.0760 4.4e-08 0.294 NA 0.281 NA -0.002 6.6e-13 NA 2.6e-12 NA 4.3e-01
23 GTEx Pituitary 0.2990 0.0750 6.0e-08 0.362 NA 0.248 NA -0.009 5.5e-10 NA 6.5e-07 NA 6.4e-01
24 GTEx Skin Not Sun Exposed Suprapubic 0.1840 0.0570 1.3e-07 0.205 NA 0.185 NA 0.017 1.9e-11 NA 2.2e-10 NA 3.9e-02
25 GTEx Skin Sun Exposed Lower leg 0.1580 0.0430 1.3e-11 0.175 NA 0.148 NA -0.002 2.2e-14 NA 2.7e-12 NA 5.6e-01
26 GTEx Small Intestine Terminal Ileum 0.2500 0.1030 1.9e-03 0.148 NA 0.086 NA 0.034 3.6e-04 NA 5.9e-03 NA 6.2e-02
27 GTEx Spleen 0.2140 0.0790 1.5e-04 0.180 NA 0.185 NA 0.020 2.3e-05 NA 1.7e-05 NA 1.0e-01
28 GTEx Stomach 0.1670 0.0630 5.9e-05 0.149 NA 0.118 NA 0.120 1.3e-07 NA 3.0e-06 NA 2.4e-06
29 GTEx Testis 0.4100 0.0810 9.9e-15 0.378 NA 0.318 NA 0.350 8.3e-18 NA 1.0e-14 NA 2.4e-16
30 GTEx Thyroid 0.1640 0.0450 1.3e-11 0.215 NA 0.205 NA 0.128 2.2e-16 NA 1.2e-15 NA 5.0e-10
31 GTEx Whole Blood 0.0390 0.0180 2.1e-03 0.047 NA 0.045 NA 0.044 3.8e-05 NA 5.4e-05 NA 5.7e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31
Bipolar Disorder (2018) 0.1 0.2 2.2 -0.2 0.4 -0.0 -0.2 -0.0 0.9 -0.3 0.2 -0.2 0.2 0.4 0.5 0.2 0.0 0.9 -0.2 -0.1 -1.5 -0.2 -0.0 -0.2 -0.2 0.1 0.0 0.2 -0.9 -0.1 -0.2 -0.2 0.1 0.2
Bipolar Disorder or Schizophrenia 0.2 0.4 3.8 -0.4 0.6 -0.1 -0.6 -0.4 -0.6 -0.4 0.6 -0.5 0.6 0.4 0.8 0.5 -0.1 0.5 -0.5 -0.8 -2.0 -0.6 -0.3 -0.5 -0.6 -0.2 -0.4 -0.2 -1.4 -0.6 -0.5 -0.5 -0.3 -0.1
Depressed Affect (Nagel 2018) 2.2 4.6 6.3 2.2 1.8 1.7 2.1 2.5 2.0 1.5 -2.3 2.3 -2.1 2.1 -2.1 -2.3 2.5 1.8 2.3 2.2 2.0 2.3 2.0 2.3 2.3 2.4 2.4 2.2 1.8 1.9 2.2 2.2 2.3 2.0
Depression (Nagel 2018) 0.0 0.1 0.7 0.0 -0.6 -0.4 0.0 0.3 -0.5 -0.3 -0.1 0.0 -0.0 -0.1 -0.0 -0.1 0.2 -0.0 0.1 -0.0 0.3 0.1 0.1 0.1 0.1 0.2 0.3 -0.0 0.8 -0.4 0.1 -0.1 -0.0 -0.1
Intelligence (Savage-Jansen 2018) 1.4 4.4 7.2 2.3 2.6 2.3 2.4 1.7 1.2 0.5 -2.2 2.2 -2.3 1.6 -2.3 -2.2 2.7 1.3 2.2 2.6 0.1 2.2 2.3 2.2 2.2 1.7 2.6 2.0 1.9 1.9 2.3 2.2 2.3 2.4
Neuroticism (Nagel 2018) 3.3 7.8 10.2 2.9 2.6 2.5 2.7 3.1 2.7 2.1 -2.9 2.9 -2.8 3.0 -2.5 -2.9 3.2 2.6 2.9 2.6 2.0 2.9 2.8 3.0 2.9 3.2 3.0 3.0 2.4 2.5 2.7 2.8 3.0 2.8
Schizophrenia (2018) 0.2 0.4 2.5 -0.5 0.4 -0.2 -0.5 -0.5 -1.6 -0.3 0.6 -0.5 0.5 0.1 0.6 0.5 -0.2 -0.1 -0.5 -0.9 -1.4 -0.6 -0.4 -0.5 -0.6 -0.3 -0.6 -0.4 -1.1 -0.7 -0.5 -0.5 -0.4 -0.2
Schizophrenia vs Biploar Disorder 0.2 0.3 1.5 0.3 1.0 0.8 0.5 0.6 -1.2 -0.3 -0.4 0.5 -0.5 0.2 -0.5 -0.5 0.3 -0.8 0.5 0.5 0.4 0.4 0.0 0.5 0.5 0.6 0.5 0.3 0.0 0.2 0.5 0.4 0.4 0.4
Worry (Nagel 2018) 3.9 8.2 13.9 2.9 2.9 2.9 2.8 3.1 2.4 2.6 -2.9 2.9 -2.9 2.9 -2.5 -2.9 3.7 2.9 2.9 2.5 1.4 2.9 2.7 2.9 2.9 3.1 3.0 3.0 3.0 2.7 2.7 2.8 3.0 3.0
Alzheimer’s Disease (in mother) 2.2 2.6 4.2 1.4 1.4 1.6 1.5 1.7 1.5 1.2 -1.7 1.6 -1.7 1.7 -1.7 -1.7 1.8 2.0 1.7 1.7 1.2 1.8 1.7 1.7 1.7 1.3 2.0 1.4 1.0 1.3 1.8 1.6 1.8 1.7
Alzheimer’s Disease (in father) 0.4 0.4 0.9 0.5 0.7 0.8 0.7 0.2 0.5 0.4 -0.6 0.6 -0.7 0.7 -0.7 -0.5 0.8 1.0 0.5 0.6 -0.6 0.5 0.7 0.6 0.6 0.4 0.6 0.8 0.2 0.3 0.5 0.6 0.8 0.9
Alzheimer’s Disease (including proxy) 2.3 3.3 5.9 1.8 1.8 1.7 1.8 1.6 1.4 1.2 -1.9 1.7 -1.9 2.1 -2.0 -1.9 2.4 2.0 1.9 2.0 0.8 1.9 1.9 2.0 1.9 1.3 2.3 1.8 1.4 1.4 1.9 1.8 2.0 2.0
Crohns Disease (2017) 0.5 1.1 3.5 -1.0 -0.2 -1.0 -1.1 -1.3 -0.9 -1.2 1.1 -1.0 1.2 -0.6 1.2 1.0 -1.3 -0.2 -1.0 -1.4 -1.9 -1.2 -1.0 -1.0 -1.1 -1.0 -1.0 -1.0 -0.9 -0.8 -1.0 -1.0 -1.0 -0.7
Irritable Bowel Disease (IBD) 1.9 4.6 8.6 -2.1 -1.8 -2.0 -2.2 -2.3 -2.0 -1.7 2.3 -2.2 2.4 -1.9 2.4 2.2 -2.6 -1.8 -2.2 -2.9 -1.6 -2.4 -1.9 -2.3 -2.3 -2.2 -2.5 -2.0 -0.8 -1.9 -2.2 -2.1 -2.3 -2.2
Ulcerative Colitis (UC) 3.0 5.7 9.6 -2.3 -2.3 -2.2 -2.4 -2.4 -2.1 -1.6 2.6 -2.5 2.5 -2.4 2.6 2.5 -2.5 -2.1 -2.5 -3.1 -1.2 -2.6 -1.9 -2.6 -2.6 -2.6 -2.9 -2.2 -0.3 -2.3 -2.5 -2.4 -2.6 -2.7
Major Depression (MDD) 0.1 0.2 1.0 -0.2 0.9 0.4 0.2 0.5 0.6 -0.0 -0.2 0.2 0.2 0.0 0.1 -0.2 0.4 0.9 0.2 0.2 0.2 0.3 0.2 0.3 0.2 0.5 0.3 0.1 1.0 0.1 0.2 0.1 0.4 0.4
Reaction Time 2.8 5.3 9.8 -2.4 -3.1 -2.5 -2.4 -2.1 -2.7 -2.0 2.3 -2.3 2.5 -2.4 2.2 2.3 -1.2 -2.0 -2.3 -2.6 -1.3 -2.3 -2.3 -2.4 -2.4 -2.4 -2.2 -1.8 -1.7 -1.9 -2.5 -2.2 -2.8 -2.8
Verbal and Numeric Reasoning (VNR) 1.5 3.6 8.6 1.9 2.4 2.0 2.0 1.3 1.1 1.1 -1.9 1.9 -1.9 2.2 -1.9 -1.9 2.9 2.2 1.9 2.0 -1.0 1.9 2.2 1.9 1.9 1.6 2.2 1.8 1.3 1.5 2.0 1.8 2.0 2.2
Breast Cancer 0.2 0.4 1.5 0.4 1.0 0.5 0.5 0.4 1.0 -0.4 -0.5 0.5 -0.5 0.1 -0.4 -0.5 1.1 1.2 0.5 0.9 -0.3 0.5 0.1 0.5 0.5 0.5 0.7 0.3 0.0 0.5 0.5 0.5 0.7 0.7
Ovarian Cancer 0.3 0.4 1.0 0.5 0.5 1.0 0.6 0.8 0.5 0.6 -0.7 0.7 -0.5 0.8 -0.7 -0.6 -0.5 -0.1 0.6 0.5 0.5 0.7 0.8 0.7 0.6 0.3 0.7 0.4 -1.0 0.6 0.7 0.6 0.7 0.6
Prostate Cancer 1.5 2.2 4.3 -1.8 -0.3 -1.1 -1.6 -1.6 -0.5 -1.1 1.6 -1.6 1.5 -2.1 1.6 1.5 -1.3 -0.9 -1.5 -1.5 -0.9 -1.6 -1.6 -1.6 -1.5 -1.7 -1.6 -1.8 -0.6 -1.8 -1.5 -1.7 -1.3 -1.5
Age at First Birth 0.5 0.7 5.6 0.8 0.6 0.9 0.9 0.9 0.2 0.6 -0.8 0.7 -0.8 0.2 -0.8 -0.8 0.5 -0.2 0.8 0.3 0.6 0.8 0.9 0.8 0.8 0.4 0.7 0.6 2.4 1.0 0.7 0.8 0.7 0.6
Bipolar Disorder (2011) 3.0 2.9 6.8 1.8 2.1 1.2 1.8 1.2 2.6 1.4 -1.6 1.7 -1.7 1.4 -1.6 -1.7 1.7 2.2 1.7 1.7 0.6 1.6 1.9 1.7 1.6 1.3 1.6 1.8 1.5 1.8 1.8 1.7 1.8 1.9
Body Mass Index (BMI) (2010) 0.4 0.6 2.5 0.7 1.6 0.7 0.8 0.4 1.1 0.1 -0.8 0.7 -0.7 0.5 -0.8 -0.7 -0.7 -0.2 0.7 0.6 0.2 0.7 0.6 0.7 0.8 0.5 0.7 0.6 1.0 0.7 0.9 0.6 0.9 0.8
Coronary Artery Disease (CAD) 0.4 0.5 6.5 0.2 1.0 -0.0 0.3 -0.4 0.9 0.2 -0.1 0.2 -0.2 0.7 -0.3 -0.3 0.9 2.5 0.3 0.3 -1.1 0.3 0.6 0.3 0.2 -0.1 0.2 -0.0 -0.1 0.1 0.6 0.3 0.4 1.0
Crohns Disease (2012) 0.2 0.3 2.2 0.5 1.5 0.9 0.4 -0.1 0.2 0.3 -0.4 0.4 -0.2 1.1 -0.3 -0.3 1.0 1.0 0.3 0.3 -0.5 0.3 0.5 0.4 0.3 0.5 0.4 0.5 -0.3 0.4 0.3 0.5 0.5 0.6
Mean Putamen Volume 0.2 0.3 1.8 0.4 1.0 -0.1 0.5 0.1 1.4 0.3 -0.4 0.3 -0.5 0.2 -0.5 -0.3 0.4 1.0 0.3 0.6 -0.3 0.4 0.6 0.4 0.4 0.0 0.4 0.1 0.7 0.4 0.5 0.3 0.5 0.3
Fasting Glucose 0.6 0.7 2.2 -0.7 -1.5 -1.5 -1.0 -0.5 -1.0 -0.1 0.6 -0.7 0.8 -1.0 0.7 0.7 -0.7 -0.9 -0.7 -1.1 0.4 -0.6 -0.9 -0.7 -0.6 -1.1 -0.6 -0.9 -1.1 -0.8 -0.6 -0.7 -0.8 -1.0
HbA1C 0.4 0.4 1.2 -0.5 -0.6 -0.8 -0.6 -0.8 0.4 -0.9 0.5 -0.5 0.7 -1.1 0.7 0.5 -0.7 0.1 -0.5 -0.8 -0.7 -0.7 -0.7 -0.6 -0.6 -0.8 -0.6 -0.3 -0.8 -0.3 -0.6 -0.5 -0.4 -0.6
HDL Cholesterol 1.2 2.1 4.5 -1.2 -0.8 -0.7 -1.5 -1.3 -1.5 -2.0 1.4 -1.6 1.3 -1.2 1.4 1.4 -2.1 -2.1 -1.4 -0.8 -1.1 -1.4 -0.8 -1.4 -1.4 -1.4 -1.2 -1.5 -1.6 -1.8 -1.5 -1.4 -1.4 -1.6
LDL Cholesterol 0.3 0.4 3.8 0.5 0.5 0.1 0.3 0.3 0.8 0.5 -0.4 0.5 -0.3 0.6 -0.2 -0.4 1.6 1.9 0.4 0.0 -0.0 0.4 0.2 0.4 0.4 0.6 0.2 0.6 0.9 0.7 0.4 0.3 0.5 0.4
Lupus 0.4 0.6 2.9 -0.6 -0.6 -0.8 -0.6 -0.4 -0.8 -0.9 0.7 -0.7 0.7 -1.0 0.7 0.7 -1.2 -1.7 -0.7 -1.1 -0.2 -0.7 -0.6 -0.7 -0.7 -0.7 -0.7 -0.3 -0.1 -0.6 -0.7 -0.5 -0.6 -0.9
Neuroticism (2016) 0.1 0.1 0.6 0.5 0.4 -0.0 0.2 0.3 0.2 -0.1 -0.2 0.2 0.1 0.4 0.1 -0.2 0.5 0.8 0.2 0.3 0.3 0.2 0.2 0.2 0.2 0.4 0.3 0.2 0.5 0.2 0.2 0.2 0.2 0.2
Primary Biliary Cirrhosis 0.2 0.3 1.7 -0.5 -0.1 -0.4 -0.5 -0.7 0.2 0.5 0.4 -0.4 0.5 -0.6 0.4 0.4 -1.1 -0.4 -0.4 -1.3 -0.6 -0.5 -0.1 -0.4 -0.4 -1.0 -0.7 -0.4 -0.3 -0.5 -0.4 -0.4 -0.2 -0.4
Rheumatoid Arthritis 1.3 1.8 2.9 -1.0 -1.3 -1.7 -1.3 -1.4 -1.6 -1.3 1.4 -1.4 1.4 -1.0 1.4 1.4 -1.3 -0.7 -1.4 -1.5 -1.3 -1.4 -1.4 -1.4 -1.4 -1.4 -1.5 -1.2 -0.6 -1.4 -1.4 -1.3 -1.5 -1.5
Schizophrenia (2014) 0.1 0.3 3.1 -0.2 0.8 0.1 -0.2 -0.2 -1.0 -0.0 0.2 -0.2 0.1 0.4 0.2 0.2 0.6 0.4 -0.2 -0.5 -1.7 -0.2 -0.2 -0.2 -0.2 0.0 -0.2 -0.1 -1.8 -0.6 -0.1 -0.2 -0.0 0.1
Triglycerides 0.0 0.1 0.3 -0.4 -0.4 -0.3 -0.1 -0.2 -0.4 -0.0 0.1 -0.1 0.2 0.0 0.2 0.3 0.5 0.5 -0.3 -0.1 -0.2 -0.2 -0.2 -0.2 -0.2 -0.0 -0.3 -0.4 -0.2 -0.4 -0.3 -0.3 -0.2 -0.2
Type 2 Diabetes (T2D) (2012) 4.8 5.6 8.4 2.1 2.3 2.6 2.5 2.9 1.7 2.2 -2.9 2.4 -2.7 1.9 -2.8 -2.4 1.2 0.9 2.4 2.3 1.1 2.7 2.5 2.6 2.8 2.4 2.8 2.0 1.3 2.5 2.5 2.5 2.8 2.6
Ulcerative Colitis 1.3 1.8 3.7 -1.2 -1.0 -1.1 -1.3 -1.6 -1.6 -0.7 1.5 -1.5 1.5 -1.2 1.5 1.5 -0.8 -0.9 -1.5 -1.9 -0.1 -1.6 -1.0 -1.5 -1.5 -1.6 -1.7 -1.3 0.0 -1.4 -1.5 -1.4 -1.5 -1.5
Blood Eosinophil Count 1.8 14.1 26.6 -3.8 -3.6 -2.9 -3.7 -3.5 -5.2 -3.2 3.7 -3.7 3.8 -4.2 3.6 3.7 -3.9 -5.1 -3.7 -4.4 -3.5 -3.9 -4.0 -3.8 -3.6 -3.6 -3.7 -3.5 -1.9 -3.2 -3.8 -3.5 -3.9 -3.6
Blood Platelet Count 1.7 19.8 26.7 4.7 4.5 4.2 4.5 4.2 4.0 4.1 -4.6 4.6 -4.4 4.7 -4.5 -4.6 2.5 3.4 4.6 4.6 3.6 4.7 4.5 4.6 4.6 4.9 4.5 4.6 4.9 4.8 4.6 4.6 4.6 5.2
Blood Red Count 0.1 1.3 10.7 0.4 0.7 -0.0 0.7 0.3 2.2 3.3 -0.7 0.7 -0.7 0.5 -0.7 -0.7 1.0 3.0 0.7 -1.1 -0.1 0.7 0.5 0.8 0.7 0.5 0.3 1.1 1.6 0.7 0.9 0.8 1.0 1.2
Blood White Count 0.1 0.9 3.7 -0.9 -1.1 -1.9 -0.8 -1.2 -0.4 -0.7 0.7 -0.6 0.9 -1.6 0.5 0.7 -1.2 -0.8 -0.7 -1.1 -0.8 -0.8 -1.2 -0.7 -0.7 -1.1 -0.9 -1.3 -0.8 -1.0 -0.5 -0.8 -0.7 -0.8
Heel T-Score 0.0 0.3 1.5 0.7 1.0 1.1 0.4 0.1 1.2 1.0 -0.4 0.4 -0.4 0.6 -0.2 -0.4 0.3 0.4 0.4 0.1 -0.3 0.4 -0.5 0.4 0.4 0.7 0.1 0.4 0.6 1.0 0.4 0.3 0.6 0.7
BMI 0.7 3.9 11.4 -1.8 -0.6 -2.4 -1.9 -3.0 0.0 -2.4 1.8 -1.8 1.8 -2.5 1.6 1.8 -2.4 -1.5 -1.8 -2.2 -2.1 -2.1 -1.5 -1.9 -1.8 -3.4 -1.8 -2.2 -1.3 -2.2 -1.4 -1.8 -1.2 -2.0
Height 0.0 0.9 11.0 -0.3 -1.3 -0.3 0.2 0.3 -1.0 -1.6 0.4 -0.3 -0.4 -1.8 -0.4 0.3 -1.6 -3.3 -0.3 0.6 1.1 -0.4 0.5 0.1 -0.3 -0.4 -0.6 -0.6 -0.7 -0.3 -0.5 -0.0 -0.8 -0.6
Waist Hip Ratio (WHR) 0.6 2.7 4.4 1.5 1.5 1.7 1.6 2.1 1.0 1.5 -1.7 1.7 -1.5 1.6 -1.5 -1.7 1.4 0.9 1.7 1.3 0.5 1.8 1.9 1.7 1.7 1.9 1.8 2.0 2.1 1.6 1.5 1.7 1.6 1.6
Systolic Blood Pressure 3.8 18.8 33.1 4.2 3.9 4.2 4.2 4.7 4.5 3.3 -4.3 4.3 -4.2 5.8 -4.1 -4.3 4.0 4.9 4.3 5.6 4.8 4.5 4.3 4.4 4.3 4.2 5.1 3.8 1.9 3.7 4.2 4.2 4.5 4.5
Smoking Status 0.3 0.6 2.9 -0.4 -1.3 -0.9 -0.4 -0.1 -0.9 -0.1 0.5 -0.5 0.4 -1.4 0.4 0.5 -1.0 -1.7 -0.5 -0.8 1.7 -0.5 -0.6 -0.6 -0.5 -0.4 -0.8 -0.2 0.4 -0.4 -0.7 -0.4 -0.9 -1.2
Allergy or Eczema 0.7 1.7 3.6 -1.3 -1.2 -1.4 -1.4 -1.8 -1.4 -1.2 1.4 -1.5 1.3 -0.7 1.4 1.4 0.0 0.5 -1.4 -1.5 -1.9 -1.4 -1.1 -1.4 -1.4 -1.4 -1.4 -1.3 0.1 -1.5 -1.4 -1.4 -1.3 -1.1
Cardiovascular Disease 2.1 7.1 14.0 2.7 2.4 2.5 2.8 2.5 3.0 1.3 -2.7 2.7 -2.7 3.2 -2.8 -2.7 2.9 2.7 2.7 3.7 2.1 2.8 2.7 2.8 2.7 1.9 3.4 1.9 -0.4 2.3 2.9 2.8 3.0 2.7
Hypothyroidism (self reported) 0.1 0.3 2.2 -0.3 0.4 -0.2 -0.0 -0.6 -0.8 -1.1 0.3 -0.3 0.2 -1.0 0.4 0.3 -0.7 -1.5 -0.3 -0.3 -0.1 -0.4 0.1 -0.4 -0.3 -0.8 -0.2 -0.3 1.1 -0.7 -0.3 -0.2 -0.4 -0.8
Respiratory disease 2.5 5.7 7.5 -2.4 -2.1 -2.5 -2.4 -2.5 -2.7 -2.4 2.5 -2.5 2.5 -2.4 2.5 2.5 -1.4 -1.6 -2.5 -2.7 -2.0 -2.6 -1.9 -2.5 -2.5 -2.7 -2.4 -2.6 -0.9 -2.4 -2.5 -2.4 -2.6 -2.7
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.9 0.7 -0.0 0.4 0.9 0.6 0.5 0.6 -0.8 0.8 -0.9 -0.1 -1.0 -0.8 0.0 0.2 0.8 0.4 1.4 0.8 0.7 0.8 0.8 0.2 0.8 0.5 0.9 0.4 0.9 1.0 0.8 0.5
Lung FEV1/FVC ratio 5.4 27.2 34.2 5.7 4.4 5.2 5.7 5.6 3.3 5.2 -5.7 5.7 -5.7 4.5 -5.6 -5.7 4.2 2.4 5.7 4.5 2.5 5.6 4.9 5.6 5.7 5.5 5.4 5.8 5.8 5.6 5.6 5.7 5.4 5.3
Lung FVC 0.6 3.0 7.8 -1.6 -1.2 -1.6 -1.8 -1.8 -1.7 -0.9 1.9 -1.9 1.8 -1.8 2.0 1.8 -1.4 -0.4 -1.8 -2.0 -2.8 -1.8 -2.0 -1.9 -1.8 -1.4 -2.0 -1.5 -0.6 -1.8 -1.8 -1.9 -1.8 -1.5
Neuroticism 4.6 11.1 16.7 3.5 2.5 2.8 3.4 4.1 3.4 2.6 -3.6 3.5 -3.5 3.1 -3.1 -3.6 3.3 2.7 3.6 3.3 2.6 3.5 3.2 3.5 3.6 3.7 3.6 3.6 2.9 3.2 3.3 3.5 3.6 3.3
Chronotype (morning person) 0.2 0.5 1.9 0.7 1.4 1.0 0.5 0.8 0.8 -0.1 -0.7 0.6 -0.5 0.9 -0.5 -0.7 0.3 0.9 0.7 1.0 0.0 0.7 0.7 0.7 0.7 0.6 0.9 0.5 -0.1 0.7 0.7 0.6 0.9 0.9
Hair Pigment 0.2 4.6 7.6 2.3 2.3 2.0 2.2 2.3 2.8 1.8 -2.2 2.2 -2.1 2.3 -2.0 -2.2 1.3 2.0 2.2 2.3 1.0 2.2 2.2 2.2 2.2 2.3 2.2 2.5 0.5 2.5 2.2 2.3 2.4 2.5
Tanning 0.0 0.5 1.5 -0.5 -0.9 -0.9 -0.7 -1.0 0.1 0.1 0.7 -0.7 0.8 -0.9 0.6 0.7 0.0 0.0 -0.7 -1.2 -0.7 -0.8 -0.7 -0.7 -0.7 -0.8 -1.2 -0.3 -0.3 -0.5 -0.7 -0.6 -0.8 -0.7
Hand grip strength (left) 0.6 1.6 5.5 -0.9 0.1 -1.2 -1.0 -1.6 -0.2 -0.7 1.1 -1.1 0.9 -1.7 1.0 1.1 -2.4 -1.4 -1.1 -1.5 -2.3 -1.4 -1.1 -1.1 -1.1 -1.8 -1.4 -1.4 -1.3 -1.2 -0.9 -1.0 -0.8 -1.0
Number of treatments/medications taken 1.3 2.4 7.6 1.3 0.9 1.4 1.4 1.6 1.7 0.6 -1.5 1.5 -1.4 1.8 -1.5 -1.5 2.8 2.0 1.5 2.1 2.0 1.5 1.3 1.5 1.5 1.4 1.8 1.4 0.2 1.3 1.6 1.4 1.5 1.2
Average weekly spirits intake 0.4 0.5 4.1 0.8 0.2 0.2 0.5 0.7 0.7 0.9 -0.6 0.6 -0.6 0.2 -0.7 -0.6 -0.3 0.1 0.6 -0.1 0.8 0.6 1.2 0.6 0.6 0.1 0.3 0.8 2.0 0.5 0.6 0.8 0.4 0.3
Sensitivity / hurt feelings 0.0 0.0 0.4 -0.2 -0.6 0.0 -0.1 0.2 0.3 0.3 -0.0 0.0 0.1 -0.1 0.3 -0.0 -0.4 -0.0 0.0 -0.5 -0.2 -0.1 0.0 0.0 0.0 0.2 -0.1 0.2 0.3 -0.1 -0.2 -0.1 0.0 -0.1
Frequency of depressed mood in last 2 weeks 1.5 2.1 4.1 1.7 0.3 0.8 1.6 2.0 0.8 0.9 -1.7 1.7 -1.6 1.1 -1.6 -1.7 1.1 0.8 1.7 1.6 1.0 1.6 1.6 1.7 1.7 1.5 1.8 1.4 1.4 1.2 1.7 1.6 1.5 1.3
Hearing difficulty/problems: Yes 0.3 0.5 1.7 0.6 0.2 0.9 0.6 0.6 0.9 0.8 -0.7 0.7 -0.6 0.6 -0.7 -0.7 -0.9 -0.5 0.7 0.6 -0.7 0.6 0.3 0.7 0.7 0.8 0.8 0.5 -0.9 1.3 0.7 0.6 0.7 0.8
Relative age of first facial hair 0.1 0.2 2.4 -0.2 -0.1 -0.0 -0.2 -0.2 -1.6 -0.5 0.2 -0.2 0.3 -0.2 0.3 0.3 0.2 -0.4 -0.3 -0.4 -1.4 -0.3 -0.2 -0.2 -0.3 -0.2 -0.2 0.2 1.1 -0.2 -0.3 -0.2 -0.5 -0.2
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 3.5 -1.7 -1.8 -1.9 -1.6 -1.7 -1.1 -1.6 1.5 -1.5 1.6 -1.5 1.5 1.5 -0.8 -0.9 -1.5 -1.5 -0.8 -1.6 -1.5 -1.6 -1.6 -1.7 -1.5 -1.5 -1.9 -1.5 -1.4 -1.7 -1.6 -1.7
Ever used hormone-replacement therapy (HRT) 0.2 0.3 3.1 -0.3 -0.4 -0.3 -0.4 -0.3 0.3 -0.7 0.3 -0.3 0.3 -0.1 0.4 0.3 1.8 1.7 -0.3 0.2 -0.5 -0.2 -0.4 -0.3 -0.3 -0.0 -0.0 -0.1 0.8 -0.2 -0.4 -0.3 -0.2 -0.2
Ever had hysterectomy (womb removed) 2.1 2.4 4.9 1.6 1.3 1.6 1.6 1.6 1.3 2.0 -1.6 1.6 -1.6 1.0 -1.6 -1.6 0.4 0.1 1.6 1.1 1.7 1.4 1.4 1.6 1.6 1.5 1.5 1.8 1.9 2.2 1.5 1.7 1.5 1.5
Systolic blood pressure, automated reading 3.0 8.7 16.4 2.6 2.7 3.2 2.7 2.8 3.1 3.4 -2.8 2.8 -2.7 4.1 -2.8 -2.8 3.3 3.6 2.8 3.3 3.7 2.9 2.7 2.9 2.8 2.8 3.1 2.4 1.3 2.4 2.8 2.8 3.0 3.1
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.7 0.8 0.7 0.5 0.7 0.6 0.9 1.2 -0.7 0.7 -0.7 0.9 -0.8 -0.7 0.0 0.5 0.7 0.5 0.7 0.8 1.3 0.7 0.7 0.6 0.7 0.8 0.7 0.3 0.8 0.8 0.8 0.7
Angina 0.8 1.0 6.8 0.9 0.8 0.9 1.0 0.6 0.8 0.5 -0.9 0.9 -1.0 1.0 -1.0 -0.9 2.6 1.9 0.9 1.1 -0.8 0.9 1.0 0.9 0.9 0.5 0.9 0.9 0.2 0.5 1.0 0.9 1.0 0.9
Medication for hormone replacement therapy 0.2 0.2 0.8 -0.2 -0.5 -0.9 -0.4 -0.4 0.6 -0.3 0.4 -0.4 0.5 -0.2 0.5 0.4 0.3 0.9 -0.4 -0.0 -0.0 -0.3 -0.6 -0.4 -0.4 -0.2 -0.3 -0.1 0.6 -0.2 -0.5 -0.4 -0.4 -0.5
Vitamin and mineral supplements 0.6 0.8 1.8 -0.9 -1.0 -0.8 -0.8 -1.0 -0.9 -1.0 0.9 -0.9 0.8 -0.5 0.9 0.9 0.3 0.9 -0.9 -0.4 -0.9 -0.8 -0.5 -0.9 -0.9 -0.8 -0.9 -1.2 -1.4 -1.3 -0.8 -0.9 -0.8 -0.4
Supplements: Zinc 0.1 0.1 0.5 0.1 0.7 0.3 0.3 0.4 0.1 -0.5 -0.3 0.4 -0.2 0.2 -0.4 -0.3 -0.2 -0.4 0.3 0.7 -0.5 0.3 0.1 0.4 0.3 0.2 0.5 -0.2 -0.2 0.2 0.4 0.2 0.4 0.2
Medication: Co-codamol 0.2 0.2 1.0 -0.3 0.2 0.0 -0.4 -0.4 0.1 -0.3 0.4 -0.4 0.4 0.1 0.6 0.4 1.0 1.0 -0.4 -0.6 -0.6 -0.5 -0.5 -0.4 -0.4 -0.3 -0.4 -0.4 0.4 -0.4 -0.4 -0.5 -0.3 -0.4
Medication: Metformin 0.2 0.3 1.4 0.4 0.4 0.2 0.6 0.4 1.1 0.2 -0.5 0.5 -0.6 -0.3 -0.5 -0.5 0.3 1.2 0.5 0.7 0.3 0.5 0.6 0.5 0.5 0.3 0.6 0.2 0.1 -0.0 0.6 0.5 0.6 0.3
Diabetes (father) 0.1 0.1 0.6 0.2 -0.1 0.4 0.2 0.4 0.1 0.5 -0.3 0.3 -0.2 0.8 -0.3 -0.3 -0.1 0.4 0.3 0.3 0.5 0.4 0.1 0.3 0.3 0.1 0.3 0.2 0.5 0.5 0.3 0.2 0.3 0.3
Diabetes (mother) 3.2 4.0 7.6 -2.1 -2.3 -2.8 -1.9 -2.1 -1.0 -2.0 1.9 -1.9 2.0 -2.7 1.8 1.9 -2.0 -1.3 -1.9 -2.0 0.2 -2.0 -2.0 -1.9 -1.9 -2.6 -2.0 -2.3 -1.9 -2.0 -1.8 -1.9 -2.0 -2.5
Severe depression (siblings) 0.5 0.6 2.6 -0.3 -1.0 -1.6 -0.5 -0.6 0.3 -1.1 0.4 -0.4 0.6 -1.2 0.6 0.4 -0.8 -0.6 -0.4 -0.7 -1.6 -0.6 -0.8 -0.5 -0.5 -0.9 -0.6 -0.6 -0.9 -0.8 -0.4 -0.5 -0.4 -0.7
Pack years adult smoking proportion 0.1 0.1 0.7 0.0 -0.7 0.5 0.0 0.4 0.5 0.1 -0.1 0.0 -0.0 0.2 -0.0 -0.1 -0.1 -0.3 0.1 -0.0 -0.3 0.0 -0.5 0.0 0.1 0.5 0.1 0.1 -0.9 0.1 -0.1 0.1 0.3 -0.0
Impedance of leg (right) 1.3 6.3 12.4 2.4 1.4 2.7 2.5 3.1 1.2 2.8 -2.5 2.5 -2.5 2.8 -2.4 -2.5 2.8 1.8 2.5 2.8 2.3 2.7 1.9 2.5 2.5 3.5 2.7 2.7 2.5 2.8 2.1 2.3 2.1 2.5
Leg fat-free mass (left) 0.6 3.3 9.2 -1.6 -1.4 -2.0 -1.5 -2.2 -0.8 -2.4 1.6 -1.6 1.5 -2.5 1.4 1.6 -3.0 -2.5 -1.6 -1.9 -1.5 -1.9 -1.0 -1.7 -1.6 -2.8 -1.7 -1.8 -1.9 -1.8 -1.4 -1.4 -1.4 -1.8
Trunk fat percentage 0.1 0.3 1.7 0.2 0.7 0.1 0.4 -0.0 1.3 0.2 -0.5 0.6 -0.4 -0.2 -0.6 -0.5 0.0 0.7 0.5 -0.1 0.1 0.3 0.6 0.5 0.5 -0.3 0.7 0.4 0.6 0.3 0.7 0.5 0.8 0.6
Hand grip strength (right) 0.1 0.3 1.8 0.7 1.2 0.3 0.6 0.2 0.9 0.3 -0.4 0.4 -0.5 -0.1 -0.4 -0.4 -1.4 -0.9 0.4 0.0 -0.8 0.2 0.3 0.4 0.4 -0.2 0.2 0.2 -0.2 0.5 0.5 0.5 0.7 0.3
Townsend deprivation index at recruitment 0.1 0.2 1.6 0.3 -0.1 -0.3 0.4 0.1 -0.5 -1.3 -0.3 0.3 -0.3 -0.4 -0.4 -0.3 0.9 0.2 0.3 0.7 -0.2 0.3 0.3 0.3 0.3 -0.0 0.5 0.1 0.7 0.0 0.3 0.3 0.1 0.1
Current tobacco smoking 0.6 1.0 2.9 1.0 -0.2 0.4 1.1 1.2 -0.1 1.7 -1.0 1.0 -1.1 0.0 -1.2 -1.0 0.7 -0.1 1.0 0.3 1.5 1.0 0.4 0.9 1.0 1.3 0.7 1.4 1.5 1.3 0.8 1.1 0.5 0.6
Average weekly fortified wine intake 0.5 0.6 1.5 0.7 0.8 1.2 0.8 0.8 0.4 0.8 -0.7 0.7 -0.8 1.0 -0.8 -0.8 -0.0 0.2 0.8 0.4 0.2 0.7 0.9 0.8 0.8 1.0 0.8 1.2 1.1 0.8 0.7 0.7 0.8 1.2
Maternal smoking around birth 0.3 0.4 1.0 -0.3 -1.0 -0.8 -0.5 -0.4 -0.2 -0.6 0.5 -0.5 0.5 -1.0 0.5 0.5 -0.6 -0.7 -0.5 -0.8 -0.6 -0.6 -0.5 -0.5 -0.5 -0.7 -0.7 -0.4 -0.7 -0.6 -0.5 -0.4 -0.6 -0.9
Fed-up feelings 1.9 3.5 4.8 1.8 1.5 1.4 2.0 2.1 1.9 1.3 -2.1 2.0 -2.0 1.9 -2.0 -2.1 1.8 1.6 2.1 2.1 1.4 2.1 2.1 2.1 2.1 1.8 2.2 1.9 1.2 1.4 2.1 2.0 2.1 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 2.1 -0.4 -1.5 -0.8 -0.3 -0.2 -1.1 -1.5 0.3 -0.3 0.3 -0.7 0.2 0.3 -0.0 -0.6 -0.3 -0.1 -0.0 -0.4 -0.5 -0.3 -0.3 -0.7 0.1 -0.5 -0.5 -0.7 -0.3 -0.5 -0.5 -0.7
Relative age voice broke 0.4 0.6 1.5 -0.9 -0.3 -0.5 -0.8 -0.9 -1.1 -0.3 0.8 -0.8 0.8 -0.3 0.9 0.8 -0.1 0.1 -0.8 -1.2 -0.8 -0.9 -1.2 -0.8 -0.8 -0.7 -0.9 -0.4 0.3 -0.7 -0.9 -0.7 -0.8 -0.7
Taking other prescription medications 1.2 1.8 3.4 1.2 1.6 1.4 1.3 1.4 1.3 0.3 -1.4 1.5 -1.4 1.2 -1.5 -1.4 1.1 0.7 1.4 1.6 1.2 1.5 1.8 1.4 1.4 0.8 1.9 1.2 1.0 0.9 1.6 1.4 1.5 1.2
Age when periods started (menarche) 0.1 0.3 2.2 0.2 -0.7 0.2 0.4 0.9 0.8 0.6 -0.3 0.3 -0.4 0.7 -0.2 -0.2 0.6 0.7 0.3 0.6 1.5 0.3 -0.1 0.3 0.3 0.7 0.4 0.6 -0.3 0.7 0.1 0.3 0.2 0.3
Bilateral oophorectomy (both ovaries removed) 2.5 2.9 5.3 1.7 1.7 1.6 1.7 1.7 2.3 2.0 -1.8 1.8 -1.7 1.4 -1.6 -1.8 1.3 1.5 1.8 1.5 2.1 1.6 1.5 1.7 1.8 1.6 1.7 1.9 1.0 1.8 1.6 1.8 1.9 1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 2.9 -1.0 -0.3 -0.2 -1.0 -1.1 0.1 0.1 1.1 -1.1 1.0 -0.8 1.1 1.2 -1.7 -1.5 -1.2 -1.2 0.5 -1.0 -1.1 -1.1 -1.1 -0.8 -1.3 -0.8 -1.2 -0.4 -1.2 -1.1 -1.0 -1.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 2.0 -0.3 -0.1 -0.3 -0.4 -0.2 0.2 -0.6 0.4 -0.4 0.5 -0.0 0.5 0.4 0.2 0.0 -0.4 -0.0 1.4 -0.4 -0.3 -0.4 -0.4 -0.1 -0.3 -0.2 -0.4 -0.6 -0.5 -0.4 -0.4 -0.6
Qualifications: CSEs or equivalent 0.2 0.2 1.3 -0.2 -0.5 -0.3 -0.2 -0.1 -0.1 -1.1 0.1 -0.1 0.2 -0.6 0.3 0.1 -0.8 -1.1 -0.1 -0.1 -1.1 -0.2 -0.6 -0.2 -0.1 -0.4 -0.0 -0.4 -0.1 -0.1 -0.1 -0.2 -0.0 -0.5
Serious illness, injury or assault to yourself 1.2 1.5 2.6 1.2 1.2 1.2 1.3 1.3 0.5 0.8 -1.4 1.4 -1.4 0.1 -1.4 -1.4 -0.3 -1.2 1.4 1.0 1.1 1.3 0.9 1.3 1.4 1.2 1.3 1.3 1.4 1.6 1.4 1.3 1.2 0.9
High blood pressure 0.3 0.8 2.5 0.6 0.2 0.7 0.7 0.6 0.9 -0.1 -0.7 0.6 -0.7 1.4 -0.8 -0.6 1.6 1.3 0.6 1.6 1.3 0.7 0.7 0.7 0.7 0.3 1.2 0.2 -1.4 0.6 0.8 0.7 0.8 0.9
Hayfever, allergic rhinitis or eczema 0.7 1.6 3.2 -1.3 -1.2 -1.2 -1.5 -1.8 -1.1 -1.1 1.4 -1.4 1.4 -0.1 1.3 1.4 0.6 0.8 -1.4 -1.2 -1.6 -1.3 -0.8 -1.3 -1.4 -1.3 -1.3 -1.3 -0.2 -1.3 -1.4 -1.3 -1.4 -1.1
Multivitamins +/- minerals 1.3 1.6 3.4 1.5 1.6 1.3 1.2 1.2 1.8 1.7 -1.3 1.3 -1.2 1.0 -1.2 -1.3 -0.1 0.0 1.3 1.0 1.2 1.3 0.8 1.3 1.3 1.2 1.1 1.2 1.8 1.5 1.3 1.3 1.4 1.0
Stomach or abdominal pain in last month 2.1 2.7 4.0 1.7 0.5 0.8 1.7 1.7 1.6 1.5 -1.8 1.9 -1.8 1.1 -1.9 -1.8 2.0 1.0 1.8 1.5 1.9 1.8 1.1 1.8 1.8 1.6 1.7 1.5 1.5 1.8 1.9 1.6 1.7 1.4
Supplements: Glucosamine 0.2 0.2 1.7 -0.4 0.1 -0.0 -0.4 -0.5 0.4 -1.0 0.4 -0.4 0.4 -0.3 0.4 0.4 -0.5 -0.3 -0.4 -0.3 -1.3 -0.5 -0.5 -0.4 -0.4 -0.2 -0.3 -0.3 -0.5 -0.1 -0.4 -0.5 -0.2 -0.3
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 3.5 -0.2 -1.4 -0.8 -0.0 0.1 0.6 0.4 -0.0 0.0 0.1 -0.8 0.0 0.0 -1.5 -0.9 -0.0 -0.5 1.9 -0.1 -0.5 0.0 0.0 -0.6 -0.3 -0.2 -0.1 -0.5 0.0 0.0 0.0 -0.4
Medication: Atenolol 0.3 0.4 3.8 0.4 0.4 0.8 0.5 0.3 0.4 0.2 -0.5 0.5 -0.5 0.5 -0.5 -0.5 1.9 1.2 0.5 0.4 -0.4 0.4 0.9 0.5 0.5 0.2 0.6 0.6 0.2 0.4 0.4 0.5 0.6 0.5
Medication: Levothyroxine sodium 0.1 0.1 0.8 0.1 0.2 0.2 0.2 0.2 0.1 -0.7 -0.2 0.2 -0.2 -0.3 -0.1 -0.2 0.2 -0.9 0.2 0.1 0.7 0.1 0.6 0.1 0.2 0.0 0.4 0.3 0.9 -0.3 0.1 0.2 0.2 -0.3
Sitting height 0.1 0.4 4.5 0.5 -0.0 0.1 0.5 0.7 0.2 -0.9 -0.4 0.4 -0.6 -1.1 -0.4 -0.4 -1.6 -2.1 0.4 0.5 0.8 0.2 0.8 0.3 0.4 -0.0 0.1 0.1 0.0 0.3 0.3 0.4 0.1 -0.1
Chronic bronchitis/emphysema (father) 1.2 1.4 5.1 -0.9 -1.7 -1.0 -0.9 -0.9 -1.8 -1.5 0.9 -0.9 0.8 -1.7 0.8 0.9 -1.5 -2.2 -0.9 -0.7 -0.6 -1.1 -1.7 -1.0 -0.9 -1.1 -0.9 -1.2 -1.1 -0.6 -1.0 -0.9 -1.3 -1.4
High blood pressure (mother) 0.7 1.0 3.8 0.9 1.0 0.7 1.0 0.9 1.2 -0.0 -0.9 0.9 -1.0 1.2 -0.8 -0.9 2.0 1.6 0.9 1.9 0.8 1.0 1.1 1.0 0.9 0.4 1.4 0.6 -0.5 0.5 0.9 0.9 1.1 0.5
Body mass index (BMI) 0.4 1.6 5.2 -1.2 -0.3 -1.4 -1.2 -2.1 0.2 -1.6 1.1 -1.1 1.1 -1.8 1.0 1.1 -1.4 -0.6 -1.1 -1.6 -1.7 -1.4 -1.1 -1.2 -1.1 -2.3 -1.1 -1.3 -1.0 -1.4 -0.8 -1.1 -0.6 -1.1
Impedance of leg (left) 1.0 5.0 10.8 2.1 1.2 2.3 2.3 3.0 1.0 2.6 -2.2 2.2 -2.2 2.5 -2.1 -2.2 2.6 1.4 2.2 2.4 2.2 2.4 1.6 2.3 2.2 3.3 2.4 2.4 2.1 2.6 1.9 2.1 1.8 2.2
Leg predicted mass (left) 0.7 3.5 9.6 -1.6 -1.4 -2.1 -1.6 -2.2 -0.9 -2.4 1.6 -1.6 1.5 -2.6 1.4 1.6 -3.1 -2.6 -1.6 -1.9 -1.5 -1.9 -1.0 -1.7 -1.6 -2.8 -1.8 -1.9 -2.0 -1.8 -1.4 -1.4 -1.4 -1.8
Trunk fat mass 0.0 0.2 1.0 -0.2 0.3 -0.5 0.0 -0.6 1.0 -0.6 -0.1 0.1 -0.1 -0.9 -0.2 -0.1 -0.8 -0.1 0.1 -0.5 -0.3 -0.2 0.1 0.0 0.0 -0.9 0.1 -0.1 -0.1 -0.2 0.3 0.1 0.4 0.0
Waist circumference 0.1 0.2 1.0 -0.4 0.2 -0.6 -0.3 -1.0 0.9 -0.7 0.2 -0.2 0.3 -0.5 0.1 0.2 -0.8 0.2 -0.2 -0.4 -1.0 -0.3 0.1 -0.3 -0.3 -0.9 -0.1 -0.4 -0.5 -0.3 -0.0 -0.2 0.1 -0.1
Number of incorrect matches in round 0.2 0.3 1.8 -0.5 -0.6 -0.5 -0.5 -0.4 -0.5 0.3 0.5 -0.5 0.5 -0.4 0.5 0.6 -0.6 -0.5 -0.6 -0.9 0.1 -0.6 -0.4 -0.5 -0.6 -0.1 -0.7 0.1 -1.4 -0.1 -0.7 -0.6 -0.8 -0.5
Past tobacco smoking 2.0 3.6 6.4 1.8 2.5 2.2 2.0 1.6 1.4 1.7 -2.0 2.1 -2.0 2.0 -2.1 -2.0 1.6 1.0 2.0 1.7 -0.1 2.0 2.0 2.1 2.0 1.6 2.2 1.9 1.4 2.0 2.1 2.0 2.1 2.2
Alcohol usually taken with meals 0.1 0.1 0.6 -0.2 -0.5 -0.1 -0.3 -0.2 0.4 -0.6 0.3 -0.3 0.3 0.4 0.4 0.3 0.2 0.7 -0.3 0.1 -0.0 -0.1 0.2 -0.2 -0.3 -0.8 -0.2 -0.6 -0.6 -0.4 -0.4 -0.2 -0.0 -0.2
Nervous feelings 1.6 3.0 9.1 1.6 1.8 1.7 1.6 1.7 1.8 1.4 -1.7 1.7 -1.6 1.8 -1.4 -1.7 3.0 2.3 1.7 1.7 -0.4 1.7 1.7 1.7 1.7 1.6 1.9 1.7 1.2 1.3 1.6 1.6 1.9 1.7
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 2.6 1.4 -0.1 0.3 1.2 1.6 0.3 0.4 -1.4 1.3 -1.3 0.6 -1.2 -1.4 0.9 -0.2 1.4 1.0 0.7 1.2 0.8 1.3 1.4 1.3 1.6 1.6 0.5 1.1 1.2 1.3 0.9 0.6
Hearing difficulty/problems with background noise 0.1 0.2 1.6 0.1 -1.1 -0.4 0.0 0.0 -0.6 0.5 -0.0 0.0 -0.0 -0.6 0.0 -0.0 -1.3 -0.6 0.0 -0.6 -1.1 -0.1 -0.2 -0.0 0.0 -0.1 -0.2 0.0 0.3 0.2 -0.1 0.0 -0.1 -0.1
Hair/balding pattern: Pattern 2 0.5 0.6 3.2 0.7 0.6 1.2 0.7 0.7 1.2 1.8 -0.6 0.6 -0.8 1.1 -0.7 -0.6 0.2 0.2 0.6 0.4 0.7 0.7 0.7 0.6 0.6 1.0 0.3 0.6 1.1 0.9 0.6 0.6 0.7 0.7
Had menopause 0.8 1.0 5.8 0.7 0.3 1.1 0.6 0.7 2.1 1.5 -0.7 0.7 -0.6 1.3 -0.6 -0.7 1.8 2.4 0.7 0.7 0.4 0.9 0.9 0.8 0.7 0.8 0.6 0.8 1.1 1.0 0.7 0.8 0.9 1.0
Had other major operations 1.8 2.1 3.1 -1.5 -1.0 -1.4 -1.6 -1.6 -1.7 -1.6 1.6 -1.6 1.6 -1.4 1.6 1.6 -1.4 -1.2 -1.6 -1.2 -0.6 -1.6 -0.9 -1.6 -1.6 -1.5 -1.5 -1.5 0.0 -1.8 -1.5 -1.6 -1.6 -1.4
Forced vital capacity (FVC) 0.3 1.2 5.2 -0.7 -0.8 -1.3 -0.8 -0.8 -1.4 -1.0 0.9 -0.9 0.7 -1.9 0.9 0.9 -2.3 -1.9 -0.9 -1.4 -1.3 -1.0 -0.7 -0.9 -0.8 -1.2 -1.1 -0.8 -0.1 -1.1 -0.8 -0.8 -1.0 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 4.2 -0.5 0.6 0.2 -0.5 -0.5 0.5 0.3 0.6 -0.6 0.5 -0.4 0.7 0.6 -2.1 -1.6 -0.6 -0.6 0.6 -0.5 -0.6 -0.6 -0.6 -0.3 -0.7 -0.4 -0.9 0.1 -0.6 -0.6 -0.4 -0.5
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.4 -0.1 -0.2 -0.3 -0.3 -0.3 0.6 -0.4 0.2 -0.2 0.3 -0.5 0.3 0.2 0.0 -0.0 -0.2 -0.3 -0.5 -0.3 -0.1 -0.3 -0.2 -0.2 -0.3 -0.1 -0.1 -0.1 -0.3 -0.3 -0.2 -0.4
Qualifications: None of the above 0.6 1.2 3.8 -1.2 -0.7 -1.2 -1.1 -1.1 -0.8 -1.3 0.9 -0.9 1.0 -1.3 0.9 0.9 -1.9 -0.8 -0.9 -1.0 -1.9 -0.9 -0.8 -0.9 -0.9 -1.0 -1.0 -1.0 -1.1 -1.5 -0.9 -1.1 -0.9 -0.8
Financial difficulties in last 2 years 0.1 0.1 1.2 -0.1 -1.1 -0.3 -0.1 -0.0 -1.0 0.3 -0.0 0.0 0.1 -0.3 -0.1 0.0 0.8 -0.3 -0.0 -0.5 0.4 -0.1 -0.7 -0.0 -0.0 -0.1 -0.1 0.1 -0.0 -0.2 -0.0 -0.1 -0.2 -0.4
Mouth/teeth dental problems 0.1 0.1 0.7 0.2 -0.1 0.2 0.2 0.3 -0.8 -0.7 -0.1 0.1 -0.2 -0.2 -0.1 -0.0 0.2 -0.8 0.0 0.3 -0.0 0.1 0.3 0.0 0.1 0.1 0.1 0.1 0.4 -0.1 0.1 0.1 -0.2 -0.1
Heart attack 0.4 0.5 1.5 0.8 0.9 1.0 0.8 0.7 1.2 0.2 -0.7 0.7 -0.8 0.2 -0.7 -0.7 0.8 0.1 0.7 0.8 -0.0 0.5 0.3 0.7 0.7 0.3 0.7 0.7 0.0 0.8 0.8 0.7 0.8 0.5
Allergy 0.3 0.8 1.7 0.8 0.6 0.7 1.0 1.3 0.5 0.8 -1.0 1.0 -0.9 0.2 -0.9 -1.0 -0.7 -0.4 1.0 1.1 0.9 0.9 0.3 0.9 1.0 0.9 1.0 0.8 -1.3 0.6 0.9 0.8 1.0 0.8
Pain all over the body in last month 0.3 0.4 3.7 0.4 1.1 0.1 0.5 -0.3 0.5 0.2 -0.4 0.4 -0.5 0.2 -0.5 -0.4 0.8 1.1 0.4 0.0 -1.9 0.3 0.2 0.4 0.4 0.2 0.4 0.5 0.4 0.3 0.5 0.3 0.6 0.6
Diabetes (self-reported) 0.6 0.9 1.5 0.9 0.1 0.7 1.1 1.0 0.6 0.7 -1.0 1.0 -1.2 0.8 -1.2 -1.0 1.0 1.2 1.0 1.1 1.1 1.1 1.2 1.0 1.0 0.7 1.1 0.8 0.6 0.3 1.0 1.1 1.0 0.7
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 1.6 0.1 -0.3 0.0 -0.1 -0.1 -1.3 -0.4 0.1 -0.1 -0.0 1.0 -0.0 0.2 1.1 0.1 -0.2 0.3 0.1 -0.0 0.3 -0.1 -0.1 0.1 0.1 -0.1 0.3 -0.0 -0.2 -0.0 -0.4 -0.1
Medication: Ramipril 0.3 0.4 3.6 -0.3 -0.2 -0.0 -0.3 -0.5 -0.5 -0.9 0.4 -0.4 0.4 -0.6 0.3 0.4 -0.5 -1.1 -0.4 -0.3 -1.9 -0.5 -0.1 -0.4 -0.4 -0.8 -0.2 -0.4 -1.0 -0.3 -0.4 -0.3 -0.4 -0.6
Medication: Simvastatin 0.9 1.3 4.2 0.9 1.1 1.1 0.9 0.8 1.2 0.8 -1.0 1.0 -0.9 2.1 -1.0 -1.0 1.1 2.0 1.0 1.7 1.1 1.1 1.1 1.1 1.0 1.0 1.2 0.7 -1.0 0.7 1.1 1.0 1.2 1.3
Fluid intelligence score 0.2 0.5 4.2 0.8 0.9 0.7 0.6 -0.1 0.0 -0.3 -0.5 0.5 -0.6 1.1 -0.7 -0.5 2.1 0.6 0.5 1.1 -1.1 0.6 0.7 0.6 0.5 -0.2 0.9 0.1 -0.2 -0.0 0.7 0.5 0.7 0.4
Illnesses of siblings 0.8 1.1 3.1 -1.1 -0.9 -1.8 -1.0 -1.3 -0.2 -1.3 1.0 -1.0 1.0 -1.6 1.0 1.0 -0.6 -0.1 -1.0 -1.2 -1.2 -1.1 -1.1 -1.0 -1.0 -1.1 -1.1 -0.9 0.1 -1.1 -1.0 -1.0 -1.0 -1.0
Neuroticism score 2.5 5.3 8.8 2.4 1.7 1.9 2.4 3.0 2.5 2.0 -2.5 2.5 -2.4 2.0 -2.2 -2.5 1.7 1.6 2.5 2.1 1.3 2.5 2.5 2.5 2.5 2.4 2.5 2.5 1.8 2.0 2.4 2.4 2.6 2.2
Weight 0.4 1.7 5.0 -1.1 -0.8 -1.5 -1.0 -1.8 -0.2 -2.0 1.0 -1.0 0.9 -2.2 0.8 1.0 -2.2 -1.7 -1.0 -1.3 -1.3 -1.3 -0.8 -1.1 -1.0 -2.2 -1.1 -1.3 -1.4 -1.2 -0.8 -0.9 -0.7 -1.2
Impedance of arm (right) 0.9 4.2 7.6 1.6 1.0 2.2 1.9 2.6 0.7 2.6 -1.9 2.0 -1.9 2.6 -2.0 -1.9 2.2 1.7 1.9 1.8 2.8 2.2 2.3 2.1 1.9 2.5 2.1 2.0 2.1 1.9 1.7 1.9 1.6 2.2
Arm fat percentage (right) 0.1 0.4 2.2 -0.8 -0.0 -0.8 -0.6 -1.3 0.6 -0.7 0.5 -0.5 0.5 -0.9 0.4 0.5 -0.6 0.3 -0.5 -1.1 -0.7 -0.7 -0.3 -0.5 -0.5 -1.5 -0.4 -0.5 -0.5 -0.8 -0.2 -0.5 -0.0 -0.4
Trunk fat-free mass 0.7 3.9 10.3 -1.6 -1.6 -2.2 -1.5 -2.1 -1.3 -2.9 1.7 -1.7 1.4 -3.0 1.4 1.7 -3.2 -3.0 -1.7 -1.5 -1.6 -1.9 -1.5 -1.8 -1.7 -2.5 -1.9 -2.0 -2.6 -1.6 -1.5 -1.4 -1.6 -1.9
Hip circumference 0.2 0.9 3.4 -0.8 -0.3 -1.0 -0.7 -1.5 0.4 -1.0 0.8 -0.7 0.7 -1.3 0.6 0.7 -1.8 -1.1 -0.7 -1.0 -1.2 -1.0 -0.5 -0.8 -0.8 -1.7 -0.8 -1.2 -1.7 -0.8 -0.4 -0.7 -0.4 -0.6
Time employed in main current job 0.2 0.3 1.5 -0.5 -0.8 -1.1 -0.5 -0.5 0.1 -0.1 0.5 -0.5 0.6 -0.8 0.5 0.4 -1.2 0.3 -0.4 -0.3 -0.0 -0.4 -0.3 -0.5 -0.5 0.1 -0.6 -0.5 -0.6 -0.3 -0.4 -0.5 -0.6 -0.1
Alcohol intake versus 10 years previously 2.1 3.1 6.7 -2.0 -2.0 -1.9 -1.8 -1.8 -1.3 -1.7 1.8 -1.8 1.7 -1.5 1.7 1.8 -1.3 -1.1 -1.8 -1.5 -0.8 -1.9 -2.1 -1.8 -1.8 -1.8 -1.4 -1.9 -2.6 -1.6 -1.8 -1.9 -1.9 -2.0
Father’s age at death 1.2 1.7 4.3 -1.4 -0.6 -1.0 -1.4 -1.4 -1.3 -1.3 1.4 -1.4 1.3 -1.2 1.4 1.4 -1.0 -0.8 -1.4 -1.0 -1.0 -1.4 -1.5 -1.4 -1.4 -1.1 -1.2 -1.3 -2.1 -1.2 -1.4 -1.3 -1.4 -1.2
Worrier / anxious feelings 3.1 5.8 9.7 2.5 2.2 2.7 2.5 3.1 2.0 2.7 -2.6 2.6 -2.6 2.1 -2.4 -2.6 0.9 -0.0 2.6 2.0 2.5 2.5 2.3 2.5 2.6 2.4 2.6 2.7 2.3 2.6 2.4 2.6 2.5 2.3
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.1 0.3 -0.1 0.1 -0.4 -0.2 -0.2 0.0 -0.4 0.1 -0.1 0.1 -0.6 0.1 0.1 -0.4 -0.3 -0.1 -0.5 0.4 -0.2 -0.3 -0.1 -0.0 -0.4 0.0 -0.2 0.2 -0.2 0.1 -0.1 -0.1 -0.3
Falls in the last year 0.2 0.2 2.8 -0.4 -0.1 -0.5 -0.3 -0.6 0.8 -0.1 0.2 -0.2 0.3 -0.2 0.2 0.2 0.6 1.7 -0.2 -0.1 0.5 -0.2 -0.7 -0.2 -0.2 -0.3 -0.2 -0.3 -0.4 -0.3 -0.1 -0.3 0.0 -0.1
Hair/balding pattern: Pattern 3 4.3 6.4 9.4 -2.4 -1.9 -2.3 -2.5 -2.5 -2.5 -3.0 2.6 -2.6 2.5 -2.4 2.6 2.6 -3.0 -3.0 -2.6 -2.1 -1.8 -2.7 -3.1 -2.6 -2.6 -2.6 -2.2 -2.6 -2.1 -2.2 -2.6 -2.6 -2.5 -2.7
Number of live births 0.2 0.3 0.9 0.9 -0.1 0.0 0.7 0.5 -0.1 0.3 -0.7 0.8 -0.7 -0.1 -1.0 -0.7 0.6 -0.8 0.7 0.5 -0.1 0.6 0.3 0.7 0.7 0.3 0.5 0.6 -0.3 0.7 0.7 0.9 0.4 0.4
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 3.1 1.5 1.1 1.1 1.4 1.2 0.0 1.2 -1.4 1.4 -1.5 0.3 -1.3 -1.4 -0.0 -0.5 1.4 0.7 -0.0 1.2 1.3 1.3 1.4 1.1 1.1 1.5 1.8 1.2 1.4 1.5 1.2 1.4
Pulse rate 0.6 1.0 3.0 -1.0 0.5 -0.9 -0.8 -1.3 -0.6 -1.5 0.8 -0.8 0.8 -1.5 0.8 0.8 -1.7 -1.2 -0.8 -0.9 -1.6 -1.0 -1.3 -0.8 -0.8 -1.0 -0.8 -0.9 -0.5 -1.1 -0.6 -0.8 -0.6 -0.7
Happiness 0.5 0.6 2.9 0.7 0.5 0.3 0.8 0.6 0.9 -0.2 -0.8 0.8 -0.8 0.5 -0.8 -0.8 1.7 1.1 0.8 1.2 1.0 0.8 0.9 0.8 0.8 0.0 1.0 0.3 -0.0 0.1 0.8 0.8 1.0 0.5
Noisy workplace 0.6 0.7 3.1 -0.9 -0.2 -1.3 -0.7 -0.9 -0.6 -0.9 0.7 -0.7 0.7 -1.5 0.6 0.7 -1.8 -1.2 -0.7 -1.3 -1.0 -0.7 -0.3 -0.7 -0.7 -0.8 -0.7 -0.2 -0.3 -0.8 -0.7 -0.6 -0.7 -0.8
Qualifications: A levels/AS levels or equivalent 0.2 0.4 3.5 0.3 0.7 0.8 0.1 0.2 -0.4 0.2 -0.2 0.2 -0.1 1.4 -0.2 -0.2 1.6 1.9 0.2 0.4 0.4 0.3 0.7 0.3 0.2 0.2 0.6 0.1 1.1 -0.1 0.2 0.2 0.4 0.7
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 3.3 -1.5 -0.5 -0.7 -1.4 -1.7 -1.8 -0.2 1.4 -1.4 1.4 -0.5 1.2 1.4 -1.3 -0.5 -1.4 -1.5 -0.2 -1.3 -0.7 -1.3 -1.4 -1.5 -1.3 -1.1 -0.6 -1.2 -1.4 -1.4 -1.4 -1.2
Mouth/teeth dental problems: Dentures 0.0 0.1 0.7 -0.1 -0.3 0.3 -0.1 0.0 0.4 0.6 -0.0 0.0 0.1 0.0 -0.0 -0.0 0.2 0.3 0.0 -0.1 0.2 -0.0 -0.6 0.0 0.0 0.3 0.1 0.2 -0.8 0.3 0.0 -0.0 0.1 0.2
Asthma 0.4 0.7 1.8 -0.6 -0.5 -0.7 -0.8 -1.0 -0.8 -0.7 0.9 -0.9 0.8 -0.9 0.9 0.9 -0.2 -0.8 -0.9 -1.3 -1.0 -0.9 -0.5 -1.0 -0.9 -1.1 -1.0 -0.7 0.8 -0.3 -0.9 -0.7 -1.0 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.4 -0.6 -0.7 -1.2 -0.8 -1.1 0.8 -0.4 0.7 -0.7 0.8 -0.9 0.6 0.7 -0.1 0.2 -0.7 -1.1 -0.8 -0.7 -0.8 -0.7 -0.7 -1.2 -0.9 -0.8 0.6 -0.9 -0.6 -0.7 -0.5 -1.0
Medication: Cholesterol lowering 3.0 4.6 7.8 2.2 2.6 2.8 2.2 1.8 1.6 1.8 -2.3 2.2 -2.2 2.6 -2.4 -2.3 1.8 0.9 2.3 2.8 1.0 2.3 2.0 2.3 2.3 1.7 2.5 1.8 0.3 1.8 2.5 2.3 2.5 2.3
Depression (self-reported) 5.1 6.1 8.5 2.9 2.0 2.4 2.7 2.7 1.8 1.5 -2.7 2.8 -2.6 2.5 -2.6 -2.7 1.7 1.1 2.7 2.9 2.4 2.7 2.6 2.7 2.7 2.1 2.8 2.4 2.2 2.4 2.7 2.8 2.8 2.3
Medication: Lansoprazole 0.6 0.7 3.0 0.9 1.0 0.7 0.7 0.6 1.7 0.8 -0.6 0.6 -0.6 0.9 -0.5 -0.6 0.9 1.2 0.6 0.7 0.9 0.6 0.8 0.6 0.6 0.4 0.6 0.9 0.5 1.1 0.7 0.8 0.8 0.8
Prospective memory result 0.1 0.1 0.9 0.1 -0.2 -0.3 0.0 -0.1 0.3 -0.2 -0.1 0.1 0.0 0.2 0.0 -0.1 -0.1 0.6 0.1 0.3 -1.0 0.1 0.4 0.0 0.0 0.2 -0.1 0.3 0.4 -0.2 0.0 0.1 -0.0 0.1
Lung cancer (father) 1.7 2.0 4.8 -1.5 -1.3 -1.8 -1.3 -1.1 -1.5 -1.7 1.2 -1.2 1.4 -1.9 1.3 1.2 -2.2 -1.8 -1.2 -1.4 -1.0 -1.3 -1.5 -1.3 -1.2 -1.2 -1.3 -1.4 0.3 -1.7 -1.3 -1.3 -1.4 -1.5
Illnesses of mother 0.3 0.4 1.4 -0.3 -0.8 -0.8 -0.4 -0.4 -1.0 -1.2 0.5 -0.4 0.5 -0.8 0.5 0.5 -0.4 -0.8 -0.5 -0.7 -1.1 -0.6 -0.6 -0.5 -0.5 -0.2 -0.6 -0.2 -0.1 -0.3 -0.5 -0.4 -0.6 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 1.3 0.5 -0.2 -0.2 0.4 0.1 -0.9 0.1 -0.3 0.3 -0.4 -0.8 -0.2 -0.3 -1.0 -1.2 0.3 -0.2 -0.6 0.1 -0.2 0.2 0.3 -0.1 -0.0 0.1 0.1 0.4 0.3 0.4 0.1 0.3
Pulse wave Arterial Stiffness index 0.2 0.2 1.9 0.2 1.0 0.5 0.2 0.2 0.2 -0.5 -0.3 0.3 -0.2 0.2 -0.2 -0.3 0.4 0.6 0.3 0.4 -1.4 0.2 0.6 0.3 0.3 0.3 0.6 0.6 0.6 -0.2 0.3 0.2 0.4 0.4
Impedance of arm (left) 0.7 3.2 6.2 1.6 0.9 1.9 1.7 2.5 0.7 2.4 -1.8 1.8 -1.6 2.1 -1.7 -1.7 1.8 1.2 1.7 1.4 1.9 1.9 2.0 1.8 1.7 2.3 1.8 2.0 2.5 1.8 1.4 1.7 1.4 1.8
Arm fat mass (right) 0.2 0.7 3.0 -0.8 -0.2 -1.1 -0.7 -1.5 0.5 -1.3 0.6 -0.6 0.6 -1.5 0.5 0.6 -1.3 -0.5 -0.6 -1.2 -0.9 -0.9 -0.5 -0.7 -0.6 -1.7 -0.6 -0.7 -0.7 -0.8 -0.3 -0.6 -0.2 -0.7
Trunk predicted mass 0.7 4.1 10.7 -1.6 -1.7 -2.3 -1.6 -2.2 -1.3 -2.9 1.7 -1.7 1.5 -3.0 1.5 1.7 -3.3 -3.0 -1.7 -1.6 -1.7 -2.0 -1.5 -1.8 -1.7 -2.6 -1.9 -2.0 -2.6 -1.7 -1.6 -1.5 -1.7 -2.0
Standing height 0.1 0.6 8.0 0.0 -1.2 -0.5 0.2 0.5 -1.0 -0.9 -0.0 0.0 -0.2 -1.4 -0.2 -0.0 -2.0 -2.8 0.0 0.1 0.4 -0.2 0.3 -0.0 0.0 -0.3 -0.2 -0.2 -0.9 0.1 -0.2 0.2 -0.5 -0.4
Length of working week for main job 3.4 3.8 7.2 -2.1 -1.5 -1.9 -2.0 -1.8 -1.1 -1.8 2.0 -2.0 2.0 -2.1 2.1 2.0 -2.7 -1.8 -2.0 -1.9 -1.2 -2.0 -1.6 -2.1 -2.0 -2.2 -2.2 -2.3 -0.7 -2.1 -2.0 -2.1 -1.9 -2.2
Exposure to tobacco smoke at home 0.2 0.2 1.8 0.0 -0.8 -0.3 -0.1 0.2 -0.2 0.0 0.1 -0.1 0.1 -0.0 0.1 0.1 -1.2 -1.4 -0.1 0.1 1.0 -0.3 -0.6 -0.1 -0.1 0.4 -0.2 0.2 -1.1 0.4 -0.4 -0.1 -0.3 -0.3
Breastfed as a baby 0.3 0.3 3.5 -0.5 -0.2 -0.3 -0.5 -0.7 -0.1 -0.7 0.5 -0.5 0.5 -0.4 0.5 0.4 0.1 0.0 -0.4 -0.5 -1.9 -0.5 -0.9 -0.5 -0.4 -0.3 -0.5 -0.4 -0.6 -0.5 -0.5 -0.5 -0.4 -0.3
Tense / ‘highly strung’ 4.9 8.2 10.8 2.9 2.8 2.7 2.8 3.0 3.1 2.5 -2.9 2.9 -2.8 3.0 -2.6 -2.9 3.0 3.3 2.9 2.7 1.2 3.0 3.1 3.0 2.9 3.0 3.1 3.0 1.8 2.7 2.9 2.9 3.2 3.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 1.9 4.4 1.5 0.9 1.4 1.3 1.6 2.1 1.1 -1.4 1.4 -1.2 1.8 -1.1 -1.3 1.8 1.9 1.3 1.5 0.9 1.4 1.3 1.4 1.3 1.4 1.4 1.3 0.2 1.4 1.3 1.3 1.5 1.2
Hair/balding pattern: Pattern 4 0.3 0.7 2.3 0.8 0.9 0.5 0.8 0.7 0.9 1.5 -0.8 0.8 -0.8 0.7 -0.8 -0.8 0.6 1.5 0.8 0.0 0.6 0.8 1.1 0.8 0.8 0.7 0.5 1.2 0.3 0.7 0.7 0.9 0.8 0.9
Birth weight of first child 0.3 0.6 1.7 0.8 1.1 0.3 0.8 0.8 -1.0 -1.1 -0.8 0.8 -0.8 0.2 -0.8 -0.8 0.7 -0.4 0.8 1.3 -0.7 0.8 0.7 0.8 0.8 0.6 0.9 0.7 1.1 0.2 0.9 0.7 0.7 0.8
Peak expiratory flow (PEF) 1.2 2.9 4.9 1.9 1.4 2.1 1.9 1.6 0.9 1.7 -1.8 1.8 -1.9 1.4 -1.9 -1.8 1.1 0.2 1.8 1.5 1.0 1.8 1.8 1.8 1.8 1.6 1.6 1.6 2.2 1.7 1.9 1.9 1.8 1.9
Pulse wave reflection index 0.4 0.5 3.8 0.4 0.6 0.7 0.5 0.4 0.5 0.4 -0.5 0.5 -0.5 1.1 -0.5 -0.5 1.7 1.9 0.5 0.7 -0.3 0.6 1.1 0.6 0.5 0.5 0.7 0.6 1.0 0.1 0.5 0.4 0.6 0.7
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.8 0.6 0.2 -0.1 0.5 0.6 0.9 -0.1 -0.7 0.7 -0.5 0.8 -0.6 -0.7 0.7 0.5 0.7 0.8 0.6 0.7 0.7 0.7 0.7 0.6 0.8 0.6 -0.5 0.7 0.7 0.6 0.7 0.5
Loud music exposure frequency 0.3 0.3 0.8 -0.6 -0.4 -0.2 -0.7 -0.5 -0.5 -0.0 0.7 -0.7 0.7 0.1 0.7 0.7 -0.3 0.2 -0.7 -0.9 0.5 -0.6 -0.7 -0.6 -0.6 -0.0 -0.7 -0.3 -0.3 -0.0 -0.7 -0.6 -0.5 -0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.3 -0.5 -1.0 -0.3 -0.6 -0.4 -0.7 -0.6 0.6 -0.6 0.6 0.3 0.7 0.6 1.1 0.6 -0.6 0.2 0.4 -0.5 -0.9 -0.6 -0.6 -0.2 -0.3 -0.9 -0.2 -0.3 -0.7 -0.7 -0.6 -0.5
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.9 0.7 1.0 0.1 0.7 0.4 0.3 -0.3 -0.7 0.7 -0.7 0.2 -0.6 -0.7 -0.0 -0.0 0.7 0.6 -0.4 0.6 0.9 0.7 0.7 0.0 0.6 0.2 0.9 0.2 0.7 0.7 0.8 0.6
Blood clot in the leg (DVT) 0.2 0.2 2.2 0.1 -0.0 -0.3 0.1 -0.1 0.3 -0.2 -0.1 0.1 -0.1 -0.4 -0.3 -0.2 -0.9 -1.4 0.2 0.3 1.5 0.1 0.0 0.1 0.1 -0.2 0.2 -0.1 0.8 0.3 0.2 0.1 -0.0 -0.2
Medication: Paracetamol 0.8 1.3 2.2 -1.3 -1.0 -1.4 -1.3 -1.3 0.3 -0.8 1.2 -1.2 1.2 -1.2 1.3 1.2 -0.5 0.2 -1.2 -1.3 -0.5 -1.3 -1.2 -1.2 -1.2 -1.3 -1.4 -1.2 -1.1 -1.5 -1.2 -1.3 -1.0 -1.4
Headache pain in last month 1.1 1.8 3.3 -1.5 -1.3 -1.4 -1.6 -1.2 -0.2 -0.5 1.4 -1.5 1.5 -1.2 1.3 1.4 -1.0 -1.7 -1.4 -1.6 -0.1 -1.4 -1.2 -1.4 -1.4 -1.4 -1.6 -1.3 -0.3 -1.5 -1.4 -1.5 -1.5 -1.8
Medication for cholesterol, blood pressure or diabetes 4.1 6.8 10.5 -2.7 -2.8 -3.0 -2.8 -2.5 -2.3 -1.6 2.8 -2.8 2.7 -2.9 2.8 2.8 -2.5 -1.7 -2.8 -3.2 -1.1 -2.8 -2.7 -2.8 -2.8 -2.1 -3.2 -2.4 -0.8 -2.4 -3.0 -2.8 -3.0 -2.7
Glaucoma (self-reported) 1.6 1.9 3.3 1.5 1.7 1.3 1.4 1.6 1.4 0.7 -1.5 1.5 -1.5 1.6 -1.4 -1.5 0.3 0.3 1.5 1.8 0.5 1.6 1.2 1.5 1.5 1.7 1.6 1.4 0.3 1.2 1.5 1.5 1.6 1.4
Gout (self-reported) 0.2 0.2 1.0 -0.3 0.8 -0.3 -0.3 -0.5 0.9 -0.5 0.3 -0.3 0.3 0.1 0.4 0.3 -0.7 1.0 -0.3 0.1 -1.0 -0.2 0.3 -0.3 -0.3 -0.5 -0.0 -0.7 -0.8 -0.5 -0.2 -0.3 0.1 -0.2
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 1.9 0.2 0.6 0.3 0.3 -0.1 0.0 -0.5 -0.2 0.2 -0.3 -0.3 -0.2 -0.2 0.3 -0.3 0.2 -0.1 0.8 0.1 0.6 0.1 0.2 -0.1 0.3 0.5 1.4 -0.1 0.2 0.3 0.2 -0.1
Medication: Amlodipine 0.3 0.4 3.4 0.3 0.5 -0.2 0.2 -0.1 1.3 -0.8 -0.2 0.1 -0.2 0.4 -0.1 -0.2 1.5 1.8 0.2 0.8 0.7 0.1 0.4 0.2 0.2 -0.4 0.5 -0.0 -0.3 -0.3 0.4 0.3 0.4 0.2
Medication: Ventolin 100micrograms inhaler 0.9 1.2 3.2 -1.0 -1.5 -1.5 -0.9 -1.0 -1.2 -1.1 1.0 -1.0 0.9 -1.8 0.9 1.0 -0.3 -0.8 -1.0 -1.5 -0.5 -1.0 -0.9 -1.1 -1.0 -1.2 -1.2 -1.0 0.6 -1.2 -0.9 -0.9 -1.2 -1.3
Birth weight 0.7 1.6 5.0 -1.3 -0.8 -1.7 -1.1 -0.7 -1.0 -1.3 1.0 -1.1 1.0 -2.2 1.1 1.0 -2.0 -1.8 -1.0 -1.8 -0.6 -1.2 -1.6 -1.1 -1.0 -1.1 -1.3 -1.1 -1.0 -1.1 -1.0 -1.1 -1.1 -1.3
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.1 -1.1 -0.9 -0.8 -1.1 -1.0 -0.7 -0.7 1.0 -1.0 1.0 -1.0 1.1 1.0 -0.1 -0.8 -1.0 -1.2 -0.3 -1.1 -1.4 -1.0 -1.0 -0.7 -1.1 -0.8 0.6 -0.9 -1.1 -1.1 -0.9 -1.0
High blood pressure (siblings) 0.2 0.3 1.6 0.4 -0.0 0.8 0.3 0.5 0.3 0.0 -0.3 0.3 -0.4 1.2 -0.4 -0.3 1.3 0.8 0.3 0.9 0.0 0.4 0.3 0.4 0.3 0.6 0.6 0.2 -1.3 0.6 0.4 0.3 0.4 0.5
Forced vital capacity (FVC), Best measure 1.1 4.0 8.2 -1.6 -1.9 -2.3 -1.7 -1.9 -2.4 -1.9 1.8 -1.8 1.7 -2.8 1.8 1.8 -2.9 -2.5 -1.8 -2.2 -1.9 -2.0 -1.9 -1.9 -1.8 -2.1 -2.2 -1.9 -1.1 -1.9 -1.7 -1.8 -2.0 -1.8
Body fat percentage 0.0 0.2 1.5 0.0 0.6 -0.0 0.3 -0.3 1.2 -0.0 -0.3 0.4 -0.3 -0.3 -0.4 -0.3 0.1 0.7 0.3 -0.2 -0.2 0.1 0.3 0.3 0.3 -0.5 0.5 0.2 0.4 0.2 0.6 0.3 0.7 0.4
Leg fat percentage (right) 0.0 0.2 0.9 -0.2 0.4 -0.2 -0.0 -0.8 1.0 -0.6 0.0 0.0 -0.0 -0.4 -0.1 -0.0 0.2 0.9 0.0 -0.2 -0.8 -0.2 -0.3 -0.0 -0.0 -0.7 0.2 -0.1 0.1 -0.1 0.2 -0.0 0.5 0.2
Arm fat-free mass (right) 0.6 2.8 8.3 -1.2 -1.3 -2.0 -1.3 -1.8 -0.5 -2.4 1.4 -1.4 1.2 -2.8 1.3 1.4 -2.9 -2.5 -1.4 -1.5 -1.4 -1.7 -1.4 -1.5 -1.4 -2.3 -1.6 -1.6 -1.8 -1.2 -1.3 -1.2 -1.3 -1.8
Exposure to tobacco smoke outside home 6.9 9.1 12.0 -3.0 -3.4 -3.3 -3.0 -3.0 -2.3 -2.3 3.1 -3.0 3.1 -3.0 2.9 3.1 -2.5 -2.6 -3.1 -2.9 -0.8 -3.2 -3.3 -3.1 -3.1 -3.2 -3.4 -3.3 -3.5 -3.1 -3.1 -3.2 -3.2 -3.4
Comparative body size at age 10 0.6 1.6 4.1 -1.1 -0.7 -1.3 -1.2 -1.6 -1.8 -1.4 1.1 -1.1 1.1 -1.5 1.1 1.1 -1.2 -0.8 -1.1 -1.8 -2.0 -1.2 -1.5 -1.1 -1.1 -1.4 -1.1 -1.1 -0.8 -1.2 -1.0 -1.1 -1.0 -1.1
Number of full brothers 0.5 0.7 5.6 -0.6 -0.5 -0.9 -0.6 -0.5 -0.7 -0.5 0.5 -0.6 0.5 -1.4 0.5 0.5 -2.4 -1.8 -0.5 -0.9 -0.4 -0.6 -0.6 -0.6 -0.5 -0.7 -0.6 -0.6 -0.6 -0.7 -0.5 -0.6 -0.6 -0.7
Worry too long after embarrassment 1.6 2.8 5.6 1.8 1.1 1.2 1.9 2.0 1.1 0.6 -1.9 1.9 -1.8 1.0 -1.6 -1.9 1.2 0.9 1.9 1.4 0.3 1.7 1.8 1.8 1.9 2.2 1.9 2.4 1.8 1.7 1.7 1.9 1.7 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 3.6 1.4 0.2 0.9 1.4 1.9 1.3 0.5 -1.4 1.4 -1.3 0.9 -1.2 -1.4 0.8 0.3 1.4 1.6 1.9 1.3 0.9 1.4 1.4 1.2 1.5 1.3 0.4 1.3 1.3 1.4 1.4 0.9
Wheeze or whistling in the chest in last year 3.5 6.2 9.3 -2.3 -2.5 -2.9 -2.5 -3.0 -1.8 -2.7 2.5 -2.5 2.5 -2.3 2.3 2.5 -1.2 -1.0 -2.5 -2.6 -2.8 -2.6 -2.3 -2.5 -2.5 -2.9 -2.6 -2.7 -1.9 -2.6 -2.4 -2.6 -2.6 -2.9
Number of children fathered 3.3 3.7 7.1 2.0 2.1 2.1 2.0 1.9 2.4 2.7 -1.9 1.9 -2.0 1.6 -2.0 -2.0 0.8 1.1 2.0 1.6 1.6 1.9 1.5 1.9 2.0 2.1 1.6 1.9 2.3 1.7 2.0 2.0 2.1 2.0
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.6 2.8 -1.2 -1.0 -1.2 -1.3 -1.2 -1.4 -1.4 1.2 -1.3 1.2 -1.1 1.3 1.2 -0.6 -0.7 -1.2 -1.2 -1.7 -1.3 -1.2 -1.2 -1.2 -1.3 -1.1 -1.3 -1.5 -1.2 -1.4 -1.2 -1.3 -1.3
Age at first live birth 0.2 0.3 2.8 -0.2 0.8 0.7 -0.3 -0.3 -1.3 -0.3 0.3 -0.3 0.3 0.3 0.5 0.3 -0.3 -0.2 -0.3 -0.2 -1.7 -0.2 -0.0 -0.2 -0.3 0.2 -0.0 -0.4 1.4 -0.2 -0.3 -0.3 -0.1 0.3
Pulse wave peak to peak time 0.2 0.3 2.1 -0.2 -1.1 -0.5 -0.2 -0.1 -0.5 0.3 0.3 -0.3 0.2 -0.3 0.2 0.4 -0.5 -1.0 -0.4 -0.3 1.4 -0.3 -0.6 -0.4 -0.4 -0.4 -0.6 -0.7 -0.8 0.2 -0.3 -0.2 -0.5 -0.5
Health satisfaction 2.4 3.1 5.0 1.8 2.2 1.5 1.8 1.7 1.5 0.3 -2.0 2.0 -1.8 1.1 -2.1 -2.0 1.7 0.7 2.0 1.7 1.1 1.9 2.2 2.0 2.0 0.9 2.1 1.7 2.2 1.5 2.0 1.9 2.0 1.5
Shortness of breath walking on level ground 0.5 0.6 1.4 0.7 0.9 0.1 0.8 0.5 0.4 -0.9 -0.8 0.8 -0.9 0.0 -0.8 -0.9 0.7 0.8 0.9 0.9 -0.4 0.7 0.8 0.8 0.8 0.4 1.2 0.8 0.8 0.1 0.9 0.8 0.9 0.5
Qualifications: College or University degree 0.2 0.5 1.2 0.9 1.1 0.9 0.7 0.6 -0.6 0.5 -0.6 0.6 -0.7 1.0 -0.7 -0.6 1.0 0.1 0.6 0.8 0.6 0.6 0.8 0.6 0.6 0.3 0.6 0.4 0.7 0.5 0.7 0.7 0.6 0.7
Eye problems/disorders: None of the above 0.6 0.6 3.9 0.6 0.4 0.6 0.7 0.5 -0.5 0.2 -0.7 0.8 -0.5 1.2 -0.7 -0.7 2.0 1.6 0.7 0.7 0.4 0.7 0.5 0.8 0.7 0.8 0.9 0.9 0.3 0.6 0.8 0.6 0.6 0.9
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.2 -0.5 -1.1 -0.8 -0.5 -0.5 0.2 -0.1 0.5 -0.5 0.5 -0.6 0.6 0.5 -0.2 0.7 -0.5 -0.9 -0.8 -0.4 -0.4 -0.5 -0.5 -0.5 -0.8 -0.4 0.7 -0.5 -0.5 -0.5 -0.4 -0.4
Emphysema/chronic bronchitis 3.6 4.0 6.2 2.0 1.1 1.4 2.1 2.5 1.2 1.7 -2.2 2.3 -2.0 1.6 -2.3 -2.2 1.5 0.9 2.2 1.9 1.6 2.3 2.1 2.3 2.2 2.4 2.2 2.3 2.2 2.0 2.2 2.1 1.9 2.0
Medication for pain relief, constipation, heartburn 0.4 0.6 4.7 -0.7 -0.4 -0.1 -0.6 -0.5 -2.2 0.2 0.7 -0.7 0.7 -0.3 0.7 0.7 -1.3 -1.4 -0.7 -0.9 -0.2 -0.6 -0.6 -0.7 -0.7 -0.2 -0.8 -0.7 -0.1 -0.4 -0.7 -0.7 -0.9 -0.3
Neck or shoulder pain in last month 0.8 1.1 2.1 -1.3 -1.4 -1.3 -1.2 -1.1 0.7 -0.6 1.0 -1.0 1.1 -1.4 0.9 1.0 -0.7 -0.6 -1.0 -1.1 -0.7 -1.0 -0.8 -1.1 -1.0 -1.5 -1.2 -1.1 -0.6 -1.3 -1.0 -1.1 -0.9 -1.4
Medication: Blood pressure 2.8 5.0 8.5 2.4 2.2 2.3 2.4 2.3 2.3 1.0 -2.4 2.4 -2.4 2.3 -2.4 -2.4 1.7 1.2 2.4 2.9 1.0 2.3 2.3 2.4 2.4 1.9 2.9 2.0 0.4 2.3 2.6 2.4 2.6 2.2
Angina (self-reported) 0.9 1.2 6.5 0.9 0.9 1.0 1.0 0.7 1.0 0.5 -1.0 1.0 -1.0 1.0 -1.0 -1.0 2.5 2.0 1.0 1.2 -0.7 1.0 1.1 1.0 1.0 0.5 1.0 1.0 0.3 0.6 1.1 1.0 1.1 0.9
Migraine (self-reported) 0.2 0.2 2.3 0.3 1.2 0.4 0.3 0.1 0.4 0.4 -0.3 0.3 -0.4 0.0 -0.2 -0.3 0.1 -0.1 0.3 0.0 0.5 0.2 0.3 0.3 0.3 0.2 0.4 0.4 1.5 0.2 0.5 0.3 0.5 0.2
Medication: Ibuprofen 0.4 0.5 1.3 -0.5 -0.5 -1.1 -0.6 -0.9 0.8 -0.6 0.6 -0.5 0.7 -1.0 0.5 0.5 0.0 0.3 -0.5 -0.9 -0.8 -0.6 -0.7 -0.6 -0.6 -1.0 -0.8 -0.7 0.7 -1.2 -0.5 -0.6 -0.3 -0.8
Medication: Allopurinol 0.2 0.3 1.7 0.4 1.2 0.3 0.3 0.1 1.2 0.1 -0.3 0.3 -0.4 0.7 -0.3 -0.3 0.0 1.3 0.3 0.7 0.5 0.4 0.5 0.4 0.4 0.1 0.5 -0.1 -0.5 0.5 0.5 0.4 0.7 0.5
Medication: Omeprazole 0.8 0.9 3.3 0.7 1.2 1.0 0.8 0.5 1.3 0.6 -0.9 0.9 -0.9 0.7 -0.9 -0.9 1.8 1.4 0.9 0.5 0.4 0.8 1.1 0.9 0.9 0.6 1.0 1.2 1.5 0.6 0.9 0.9 1.1 0.7
Medication: Seretide 50 evohaler 0.8 0.9 1.9 0.9 0.4 0.9 1.0 1.2 0.5 1.3 -1.0 1.0 -1.0 0.3 -0.9 -1.0 -0.5 -1.4 1.0 0.3 0.7 0.9 0.6 0.9 1.0 0.9 1.0 1.3 1.2 1.3 0.9 1.1 0.8 0.6
Mean time to correctly identify matches 1.2 2.2 6.2 -1.5 -2.5 -1.4 -1.6 -1.1 -2.0 -1.4 1.5 -1.5 1.6 -1.4 1.5 1.5 -0.5 -1.3 -1.5 -1.4 -0.5 -1.4 -1.8 -1.5 -1.5 -1.1 -1.3 -1.0 -1.2 -0.8 -1.7 -1.4 -1.9 -1.7
Heart disease (mother) 1.1 1.3 3.5 -1.2 -1.9 -0.9 -1.1 -1.0 -1.4 -0.5 1.1 -1.1 1.1 -1.1 0.8 1.1 -1.5 -1.8 -1.1 -0.8 0.7 -1.1 -1.1 -1.1 -1.1 -1.2 -1.1 -1.4 -1.0 -0.9 -1.1 -1.1 -1.3 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.9 -0.5 -0.5 -0.4 -0.5 -0.6 -0.2 -0.3 0.5 -0.5 0.5 -0.2 0.5 0.5 -0.5 0.1 -0.5 -0.5 -0.4 -0.5 -0.3 -0.5 -0.5 -0.5 -0.6 -1.0 -0.8 -0.9 -0.3 -0.5 -0.3 -0.5
Whole body fat mass 0.1 0.3 1.6 -0.5 0.0 -0.7 -0.3 -0.9 0.8 -1.1 0.2 -0.2 0.2 -1.2 0.1 0.2 -1.0 -0.3 -0.2 -0.7 -0.7 -0.5 -0.2 -0.3 -0.3 -1.3 -0.1 -0.4 -0.6 -0.4 0.0 -0.2 0.2 -0.2
Leg fat mass (right) 0.1 0.3 1.3 -0.4 0.0 -0.6 -0.3 -1.1 0.7 -1.0 0.3 -0.2 0.2 -0.9 0.1 0.3 -0.8 0.0 -0.3 -0.6 -0.9 -0.5 -0.4 -0.3 -0.3 -1.1 -0.1 -0.4 -0.4 -0.4 0.0 -0.2 0.2 -0.2
Arm predicted mass (right) 0.5 2.7 7.5 -1.2 -1.2 -2.0 -1.2 -1.7 -0.6 -2.5 1.3 -1.3 1.2 -2.7 1.2 1.3 -2.7 -2.5 -1.3 -1.3 -1.3 -1.6 -1.4 -1.4 -1.3 -2.2 -1.5 -1.6 -1.9 -1.3 -1.2 -1.2 -1.2 -1.7
Pulse rate, automated reading 0.1 0.2 1.7 -0.2 1.3 -0.1 0.0 -0.4 1.0 -0.3 -0.1 0.1 -0.0 -0.1 -0.1 -0.1 -1.2 -0.1 0.1 0.3 0.2 -0.0 -0.2 0.1 0.1 0.0 0.3 -0.4 -1.2 -0.4 0.5 0.0 0.5 0.5
Alcohol intake frequency. 0.2 0.4 3.0 0.4 1.3 0.9 0.5 -0.1 0.2 0.3 -0.5 0.5 -0.5 -0.0 -0.8 -0.5 -0.2 -1.7 0.5 0.4 0.2 0.4 0.6 0.5 0.5 -0.2 0.5 0.2 -0.4 0.4 0.8 0.5 0.6 0.2
Comparative height size at age 10 0.1 0.3 3.3 0.2 -0.3 0.2 0.3 0.3 -0.1 0.4 -0.2 0.2 -0.3 -0.4 -0.4 -0.1 -1.5 -1.8 0.1 0.2 1.3 0.0 -0.0 0.1 0.2 0.2 -0.1 0.1 -0.8 0.6 0.1 0.2 -0.1 -0.1
Number of full sisters 1.1 1.3 4.6 -1.0 -0.7 -1.0 -1.0 -1.1 -1.1 -1.7 1.1 -1.1 0.8 -1.5 0.9 1.1 -1.5 -2.1 -1.1 -0.9 -0.3 -1.2 -0.8 -1.1 -1.0 -1.4 -1.0 -1.2 -0.6 -0.9 -0.9 -1.0 -1.1 -1.3
Suffer from ‘nerves’ 0.9 1.3 3.9 1.1 0.9 1.1 1.0 1.3 0.6 1.0 -1.1 1.1 -1.0 1.3 -0.9 -1.1 2.0 1.7 1.1 0.9 0.3 1.3 1.5 1.1 1.1 1.3 1.2 1.1 1.7 0.5 1.0 1.0 1.2 1.1
Overall health rating 0.1 0.2 0.7 -0.5 -0.5 -0.8 -0.4 -0.6 0.1 0.3 0.4 -0.4 0.5 -0.4 0.2 0.4 0.4 -0.2 -0.4 -0.8 0.2 -0.4 -0.0 -0.4 -0.4 -0.5 -0.6 -0.4 -0.6 -0.7 -0.3 -0.6 -0.5 -0.8
Chest pain or discomfort 0.3 0.5 1.8 0.8 -0.2 0.2 0.7 0.7 1.0 0.5 -0.8 0.8 -0.8 0.7 -0.9 -0.8 1.4 0.7 0.8 0.8 -0.4 0.8 0.2 0.8 0.8 0.5 0.7 0.5 0.1 0.5 0.8 0.6 0.8 0.5
Had major operations 0.6 0.8 2.3 0.7 0.9 1.0 0.9 1.0 1.0 1.1 -0.8 0.8 -0.8 0.5 -0.7 -0.8 1.1 0.6 0.8 0.5 0.7 0.8 1.5 0.7 0.8 0.9 0.7 1.3 1.1 0.8 0.8 0.9 0.8 0.8
Age at last live birth 0.1 0.2 2.2 -0.2 0.4 0.3 -0.2 -0.4 -1.1 -0.1 0.2 -0.2 0.2 -0.0 0.2 0.2 0.0 0.1 -0.2 -0.0 -1.5 -0.1 -0.3 -0.2 -0.2 0.3 -0.0 -0.5 0.7 -0.2 -0.2 -0.2 -0.1 0.3
Family relationship satisfaction 1.7 2.1 4.5 -1.4 -2.1 -1.9 -1.3 -1.3 -2.1 -2.0 1.3 -1.3 1.4 -1.4 1.2 1.3 -0.7 -1.2 -1.3 -0.8 -0.5 -1.3 -1.1 -1.3 -1.3 -1.9 -1.0 -1.7 -1.7 -1.7 -1.3 -1.4 -1.4 -1.6
Leg pain on walking 0.1 0.1 1.1 0.1 -0.1 -0.3 0.0 0.2 0.1 -0.5 -0.2 0.2 -0.1 -0.4 -0.2 -0.2 1.0 0.5 0.2 0.1 0.7 0.1 0.1 0.2 0.2 -0.2 0.2 0.1 0.7 -0.2 0.2 0.2 0.2 -0.1
Qualifications: NVQ or HND or HNC or equivalent 3.0 3.6 5.7 -1.7 -2.0 -2.3 -1.9 -1.8 -1.1 -1.9 1.9 -1.9 1.8 -2.4 1.9 1.9 -2.0 -1.5 -2.0 -2.0 -0.4 -2.1 -2.2 -2.0 -1.9 -2.0 -2.0 -1.9 -0.8 -1.4 -2.1 -1.9 -2.1 -2.3
Commuting to job workplace: Car/motor vehicle 2.6 3.0 5.0 -1.8 -1.1 -1.6 -1.8 -1.7 -1.6 -2.2 1.8 -1.8 1.8 -1.9 1.8 1.8 -1.6 -1.6 -1.8 -1.6 -1.6 -1.8 -1.5 -1.8 -1.8 -1.8 -1.6 -1.9 -0.7 -2.2 -1.7 -1.8 -1.7 -1.9
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 3.1 0.6 0.7 0.7 0.7 0.9 1.1 0.5 -0.6 0.6 -0.6 1.1 -0.4 -0.6 1.5 1.8 0.6 1.0 -0.3 0.8 0.7 0.6 0.6 0.6 0.7 0.4 0.1 0.4 0.6 0.7 0.8 1.0
Medication: Aspirin 1.0 1.3 3.3 1.3 0.8 0.8 1.3 1.1 1.4 0.2 -1.2 1.2 -1.3 1.2 -1.4 -1.2 1.0 0.7 1.2 1.8 1.1 1.2 1.3 1.2 1.2 0.7 1.4 1.1 -0.0 1.1 1.2 1.3 1.2 0.9
Supplements: Vitamin C 0.3 0.3 0.9 0.5 -0.3 0.4 0.7 0.8 -0.0 -0.1 -0.7 0.7 -0.6 -0.1 -0.7 -0.7 0.0 -0.9 0.7 0.3 0.3 0.5 0.3 0.7 0.7 0.2 0.7 0.9 0.9 0.7 0.5 0.6 0.4 0.3
Knee pain experienced in last month 0.0 0.1 0.8 0.1 -0.1 -0.0 0.1 -0.1 0.9 0.1 -0.2 0.2 -0.1 0.2 -0.3 -0.2 0.0 0.5 0.2 -0.1 -0.6 0.2 0.3 0.2 0.2 -0.3 0.1 -0.1 0.2 0.0 0.3 0.1 0.4 0.0
Hypertension (Self-reported) 0.4 1.2 3.3 0.9 0.7 0.9 1.0 0.9 1.3 0.3 -1.0 1.0 -1.0 1.5 -1.1 -1.0 1.8 1.4 1.0 1.7 1.4 1.0 1.0 1.0 1.0 0.5 1.4 0.5 -0.9 0.9 1.2 1.0 1.1 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.8 0.7 0.8 0.6 0.5 0.2 1.1 0.0 -0.6 0.6 -0.6 0.7 -0.6 -0.6 1.3 1.3 0.6 0.6 0.5 0.5 0.9 0.6 0.6 0.1 0.7 0.8 1.1 0.4 0.6 0.7 0.7 0.6
Illnesses of father: Heart disease 0.3 0.4 2.3 0.7 0.8 0.9 0.2 0.3 1.0 0.5 -0.3 0.3 -0.2 1.2 -0.4 -0.4 0.6 0.1 0.4 0.9 1.0 0.5 1.5 0.4 0.3 0.2 0.4 0.2 0.9 -0.1 0.4 0.3 0.4 0.1
Illnesses of siblings: Diabetes 0.5 0.6 2.2 -0.8 -0.7 -0.3 -0.8 -0.8 -1.5 -0.4 0.8 -0.8 0.8 -0.8 0.7 0.8 -0.7 -0.7 -0.8 -1.1 0.1 -0.8 -0.4 -0.8 -0.8 -0.9 -0.8 -0.6 0.0 -0.8 -0.9 -0.7 -0.9 -1.0
Smoking status: Previous 2.1 3.1 4.5 -1.7 -1.9 -1.7 -2.0 -1.5 -0.7 -1.8 2.0 -2.0 2.0 -1.5 2.1 2.0 -2.0 -0.9 -2.0 -1.5 -0.1 -1.9 -1.8 -2.0 -2.0 -1.5 -2.1 -1.8 -1.5 -1.9 -2.0 -2.0 -1.8 -2.0
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 5.3 -0.6 -0.5 -1.1 -0.5 -0.5 -1.1 -1.0 0.5 -0.5 0.5 -1.4 0.5 0.5 -2.0 -2.3 -0.5 -1.0 -1.4 -0.6 -0.1 -0.6 -0.5 -1.1 -0.6 -0.7 -1.1 -0.7 -0.4 -0.5 -0.7 -0.8
Whole body fat-free mass 0.7 4.2 11.3 -1.7 -1.6 -2.4 -1.6 -2.3 -1.2 -2.9 1.8 -1.8 1.6 -3.0 1.5 1.8 -3.4 -3.0 -1.8 -1.8 -1.6 -2.1 -1.4 -1.9 -1.8 -2.8 -1.9 -2.1 -2.5 -1.8 -1.6 -1.5 -1.6 -2.0
Leg fat-free mass (right) 0.8 4.2 10.6 -1.7 -1.6 -2.3 -1.8 -2.3 -1.1 -2.7 1.8 -1.8 1.7 -2.8 1.6 1.8 -3.3 -2.9 -1.8 -2.1 -1.6 -2.1 -1.2 -1.9 -1.8 -3.0 -2.0 -2.1 -2.3 -2.0 -1.6 -1.6 -1.7 -2.1
Arm fat percentage (left) 0.1 0.6 2.7 -0.8 -0.1 -1.0 -0.7 -1.4 0.8 -0.8 0.6 -0.6 0.6 -1.2 0.5 0.6 -0.9 0.1 -0.6 -1.3 -0.9 -0.8 -0.4 -0.7 -0.6 -1.6 -0.5 -0.6 -0.1 -0.8 -0.3 -0.6 -0.1 -0.5
Average weekly red wine intake 1.5 2.2 8.4 1.4 1.3 1.8 1.2 1.2 1.4 1.7 -1.2 1.2 -1.2 1.9 -1.1 -1.2 2.9 2.3 1.2 0.9 0.2 1.3 1.4 1.3 1.2 1.0 1.1 1.3 2.8 1.0 1.0 1.2 1.4 1.3
Handedness (chirality/laterality): Left-handed 0.1 0.2 2.2 0.3 0.6 0.2 0.2 0.0 -0.2 0.2 -0.3 0.3 -0.1 0.3 -0.3 -0.3 -0.2 -0.0 0.3 -0.0 -0.8 0.3 1.5 0.3 0.3 -0.0 0.2 0.4 -0.1 -0.3 0.3 0.4 0.2 0.3
Mood swings 0.4 0.7 1.5 0.8 0.8 0.9 0.8 1.1 1.2 1.1 -0.8 0.7 -0.8 1.1 -0.7 -0.8 0.8 0.6 0.8 0.7 0.9 0.8 1.2 0.8 0.8 1.1 0.7 1.1 0.6 0.7 0.7 0.7 0.7 0.7
Loneliness, isolation 0.3 0.5 1.4 0.8 -0.3 -0.2 0.8 1.2 0.4 -0.1 -0.9 0.9 -0.8 -0.0 -0.9 -0.9 0.3 -0.2 0.9 0.7 0.8 0.9 0.5 0.8 0.9 0.5 0.9 0.4 0.1 0.2 0.8 0.8 0.8 0.4
Long-standing illness, disability or infirmity 0.1 0.1 0.6 -0.2 -0.1 -0.1 -0.2 -0.4 0.1 -0.8 0.1 -0.2 0.1 -0.1 0.0 0.1 0.5 -0.2 -0.1 0.2 0.4 -0.1 0.4 -0.2 -0.1 -0.5 0.0 -0.2 -0.0 -0.6 0.0 -0.2 -0.1 -0.5
Ever had bowel cancer screening 0.8 0.9 2.4 1.0 0.8 0.7 0.8 1.0 1.1 0.1 -1.0 1.0 -0.8 0.6 -0.8 -1.0 0.5 0.4 1.0 1.0 0.8 1.0 0.9 0.9 1.0 1.2 1.1 1.3 1.6 1.2 1.1 0.9 0.9 0.8
Diabetes diagnosed by doctor 1.1 1.8 2.7 1.4 0.7 1.2 1.5 1.3 1.3 1.1 -1.5 1.4 -1.6 1.2 -1.6 -1.5 1.3 1.3 1.5 1.6 1.3 1.5 1.7 1.5 1.5 1.1 1.6 1.2 0.6 1.0 1.5 1.6 1.5 1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 2.6 -0.5 -0.6 -0.6 -0.6 -0.6 -1.6 -0.6 0.5 -0.5 0.6 -0.3 0.3 0.5 0.2 -0.6 -0.5 -0.4 -1.2 -0.4 0.1 -0.5 -0.6 -0.7 -0.5 -0.6 -0.8 -0.9 -0.5 -0.4 -0.8 -0.5
Friendships satisfaction 0.7 0.8 2.1 -0.7 -1.3 -1.0 -0.5 -0.8 -1.5 -1.2 0.7 -0.7 0.6 -0.8 0.5 0.7 -0.1 -1.4 -0.7 -0.2 0.5 -0.8 -0.9 -0.7 -0.7 -1.3 -0.5 -1.4 -1.4 -1.2 -0.6 -0.7 -0.7 -1.1
Qualifications: nursing, teaching 0.3 0.4 1.8 0.5 0.9 0.4 0.6 0.4 1.3 -0.2 -0.5 0.5 -0.6 0.9 -0.5 -0.5 1.0 1.2 0.5 1.0 0.7 0.5 0.6 0.5 0.5 0.0 0.8 0.2 0.1 0.6 0.5 0.5 0.8 0.5
Commuting to job workplace: Walk 1.5 1.6 2.7 1.4 0.3 0.9 1.6 1.4 1.3 1.2 -1.5 1.5 -1.5 0.8 -1.6 -1.4 1.1 0.9 1.4 1.3 0.3 1.3 1.0 1.4 1.4 1.1 1.4 1.5 -0.1 1.6 1.4 1.5 1.3 1.3
Eye problems/disorders: Cataract 0.4 0.4 1.3 0.7 0.9 1.0 0.6 0.7 0.6 0.5 -0.5 0.5 -0.6 0.9 -0.5 -0.6 0.1 -0.1 0.6 1.1 1.1 0.6 0.7 0.5 0.6 0.4 0.9 0.4 0.2 0.5 0.5 0.6 0.7 0.5
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 1.9 -0.2 0.5 -0.1 -0.3 -0.5 1.3 0.2 0.2 -0.2 0.2 0.3 0.2 0.2 0.4 1.4 -0.2 -0.1 0.5 -0.2 -0.1 -0.2 -0.2 -0.2 -0.2 -0.3 -0.8 -0.2 -0.2 -0.2 0.1 -0.1
Medication for cholesterol 0.3 0.5 5.9 -0.1 0.4 -0.0 -0.0 -0.2 -0.7 0.8 0.0 0.0 -0.0 -1.1 -0.1 -0.0 -1.9 -2.4 0.0 -1.2 -1.1 -0.2 -0.2 -0.0 -0.0 -0.1 -0.5 0.1 0.5 0.0 0.1 -0.0 -0.1 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.0 0.3 -0.0 -0.3 0.0 -0.1 0.5 0.1 0.2 0.0 -0.1 0.1 0.4 0.1 0.1 -0.2 -0.4 -0.1 0.1 0.2 0.1 0.2 0.0 -0.0 0.5 -0.1 0.1 0.3 0.1 -0.2 -0.2 -0.1 -0.3
Back pain experienced in last month 0.4 0.5 1.2 -0.8 -1.0 -1.1 -0.8 -0.7 -0.1 -0.7 0.7 -0.7 0.8 -1.0 0.7 0.7 -0.1 -0.6 -0.7 -0.6 0.4 -0.8 -0.7 -0.7 -0.7 -0.7 -0.8 -0.6 -0.4 -0.4 -0.8 -0.8 -0.9 -1.1
Mineral and other dietary supplements 0.1 0.1 0.5 0.1 -0.2 0.4 0.3 0.1 -0.4 0.5 -0.3 0.3 -0.3 -0.1 -0.3 -0.2 0.6 0.3 0.2 -0.1 0.7 0.2 0.5 0.2 0.3 -0.1 0.2 0.3 0.6 0.1 0.2 0.3 0.1 0.3
Breast cancer (self-reported) 0.2 0.2 1.7 -0.6 -0.1 -0.1 -0.4 -0.2 -0.7 -0.5 0.3 -0.3 0.4 -0.3 0.3 0.3 -0.9 -0.8 -0.3 -0.5 -1.3 -0.4 -0.0 -0.3 -0.3 -0.1 -0.1 -0.5 -0.8 -0.6 -0.3 -0.4 -0.3 -0.1
Asthma (self-reported) 0.3 0.6 1.4 -0.6 -0.3 -0.6 -0.7 -0.8 -0.6 -0.6 0.8 -0.8 0.7 -0.7 0.8 0.8 -0.2 -0.6 -0.8 -1.2 -0.9 -0.8 -0.4 -0.9 -0.8 -1.0 -0.9 -0.7 0.8 -0.3 -0.8 -0.6 -0.8 -1.0
Osteoporosis (self-reported) 0.1 0.1 1.1 -0.1 -0.1 0.2 -0.0 0.3 -0.7 -0.2 0.0 -0.0 0.0 0.1 0.0 -0.0 1.0 0.1 0.0 0.7 -0.1 0.2 -0.4 -0.0 0.0 0.6 0.2 -0.1 -0.3 0.0 -0.1 -0.0 -0.1 0.1
Osteoarthritis (self-reported) 0.5 0.6 2.3 -0.8 0.4 -0.9 -0.8 -0.9 0.6 -1.3 0.7 -0.7 0.8 -1.0 0.8 0.7 -0.2 -0.0 -0.7 -0.6 -1.1 -0.6 0.2 -0.8 -0.7 -1.5 -0.8 -0.9 0.1 -1.1 -0.5 -0.8 -0.4 -0.9
Medication: Aspirin 0.5 0.7 2.2 0.8 0.4 0.4 0.9 0.7 1.3 -0.1 -0.8 0.8 -0.9 0.9 -1.0 -0.8 0.7 0.9 0.8 1.5 0.8 0.8 0.9 0.9 0.8 0.3 1.0 0.6 -0.7 0.6 0.9 0.9 0.8 0.5
Medication: Gliclazide 2.7 3.1 4.9 1.9 1.7 1.6 2.0 2.0 1.6 1.4 -2.0 2.0 -1.9 1.1 -2.0 -2.0 0.1 -0.3 2.0 1.9 2.2 1.9 1.6 1.9 1.9 1.7 1.9 1.7 1.0 1.7 1.9 2.1 1.9 1.6
Illnesses of father: None of the above (group 1) 0.1 0.1 1.0 -0.1 -0.1 -0.7 0.0 0.1 0.3 0.5 -0.0 0.0 0.0 -0.8 0.1 0.0 -0.2 -0.0 -0.0 -1.0 -0.4 -0.0 -0.3 -0.0 -0.0 0.2 -0.5 0.2 1.0 -0.1 -0.0 -0.0 0.0 -0.1
Smoking status: Current 0.5 0.8 2.5 0.9 -0.1 0.3 1.0 1.0 -0.3 1.3 -0.9 0.9 -1.0 -0.2 -1.1 -0.9 0.8 -0.1 0.9 0.3 1.4 0.9 0.4 0.8 0.9 1.1 0.6 1.3 1.6 1.2 0.7 1.0 0.4 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 1.6 0.7 -0.0 -0.1 0.5 0.2 -0.5 -0.2 -0.5 0.5 -0.4 -0.2 -0.4 -0.5 0.2 0.0 0.5 0.1 -0.7 0.3 -0.1 0.4 0.5 0.3 0.4 0.5 1.3 0.5 0.5 0.6 0.4 0.5
Whole body water mass 0.7 4.1 11.1 -1.7 -1.6 -2.3 -1.6 -2.2 -1.1 -2.8 1.7 -1.7 1.5 -3.0 1.5 1.7 -3.3 -2.9 -1.7 -1.7 -1.5 -2.0 -1.4 -1.8 -1.7 -2.8 -1.9 -2.0 -2.4 -1.8 -1.5 -1.5 -1.6 -2.0
Leg predicted mass (right) 0.8 4.2 11.0 -1.7 -1.5 -2.3 -1.8 -2.3 -1.1 -2.7 1.8 -1.8 1.7 -2.8 1.6 1.8 -3.3 -3.0 -1.8 -2.0 -1.6 -2.1 -1.2 -1.9 -1.8 -3.0 -1.9 -2.1 -2.3 -2.0 -1.6 -1.6 -1.6 -2.1
Arm fat mass (left) 0.3 1.2 4.2 -1.1 -0.4 -1.4 -0.9 -1.7 0.3 -1.6 0.9 -0.9 0.9 -1.9 0.8 0.9 -1.5 -0.7 -0.9 -1.5 -1.2 -1.2 -0.8 -1.0 -0.9 -2.0 -0.8 -1.0 -0.7 -1.1 -0.6 -0.8 -0.5 -1.0
Number of self-reported non-cancer illnesses 0.5 0.9 6.3 0.7 0.9 0.8 0.6 0.6 -0.3 -0.4 -0.7 0.7 -0.7 1.5 -0.8 -0.7 2.5 1.4 0.7 1.2 1.4 0.8 1.5 0.7 0.7 0.3 1.2 0.7 0.9 0.4 0.8 0.7 0.6 0.7
Average weekly champagne plus white wine intake 0.2 0.2 1.3 -0.4 -0.2 -1.1 -0.4 -0.4 -0.3 -0.8 0.3 -0.3 0.4 -0.9 0.4 0.3 0.3 1.0 -0.3 -0.5 -0.6 -0.4 -0.4 -0.4 -0.3 -0.4 -0.4 -0.2 0.5 -0.5 -0.4 -0.3 -0.3 -0.2
Miserableness 0.6 1.0 2.6 1.0 0.5 0.4 1.0 1.2 0.8 -0.3 -1.1 1.1 -0.9 0.3 -1.0 -1.1 1.3 0.5 1.1 0.9 0.5 1.0 1.3 1.1 1.1 0.9 1.2 1.2 1.6 0.7 1.1 1.0 0.9 0.6
Guilty feelings 1.1 1.7 4.7 1.5 0.3 0.8 1.4 2.2 0.4 0.6 -1.5 1.5 -1.5 1.0 -1.4 -1.5 -0.0 -0.5 1.5 1.7 1.2 1.5 1.2 1.5 1.5 1.5 1.7 1.3 0.5 1.0 1.4 1.5 1.3 1.1
Wears glasses or contact lenses 0.2 0.2 2.2 0.1 0.4 0.5 -0.0 0.1 1.2 0.4 0.0 -0.0 0.0 0.2 0.2 0.0 0.5 0.8 -0.0 0.1 0.1 0.1 -0.3 0.0 -0.0 0.3 0.1 0.2 1.5 0.7 -0.1 -0.0 0.2 0.0
Ever taken oral contraceptive pill 0.2 0.2 1.8 -0.1 -0.8 -0.7 -0.2 -0.1 -0.3 0.4 0.1 -0.1 0.1 -0.2 0.2 0.1 0.3 0.8 -0.1 -0.7 -0.8 -0.0 -0.2 -0.2 -0.1 -0.4 -0.3 -0.2 1.4 -0.2 -0.2 0.0 -0.2 -0.3
Hearing aid user 0.8 0.9 2.6 -0.8 -0.6 -0.8 -0.7 -0.9 0.1 -1.3 0.9 -0.8 0.6 -0.8 0.9 0.9 -1.1 -0.8 -0.9 -0.5 -1.1 -1.0 -0.8 -0.9 -0.9 -1.6 -0.6 -1.2 -1.5 -1.2 -0.8 -0.7 -0.5 -1.1
Mother’s age at death 0.4 0.5 3.5 -0.7 0.0 -0.2 -0.7 -0.8 -1.0 0.0 0.7 -0.6 0.8 -0.3 0.7 0.7 -0.2 0.2 -0.7 -0.9 -1.9 -0.6 -0.0 -0.7 -0.7 -0.7 -0.7 -0.5 -0.7 -1.0 -0.6 -0.7 -0.5 -0.4
Financial situation satisfaction 0.3 0.4 1.5 -0.2 -1.2 -1.1 -0.3 -0.6 -0.8 -1.1 0.2 -0.3 0.2 -1.1 0.3 0.3 0.4 -0.4 -0.3 -0.3 -0.3 -0.6 -0.9 -0.3 -0.2 -0.5 -0.2 -0.4 -1.0 -0.5 -0.4 -0.2 -0.5 -0.7
Tinnitus: Yes, now most or all of the time 0.9 1.0 5.3 -1.0 -0.5 -0.9 -0.8 -1.0 -0.5 -1.3 0.7 -0.7 0.7 -1.6 0.5 0.7 -1.9 -2.3 -0.7 -1.1 -0.4 -0.9 -0.6 -0.8 -0.7 -1.4 -0.7 -1.1 -0.6 -0.9 -0.5 -0.7 -0.7 -1.1
Commuting to job workplace: Public transport 0.4 0.5 1.3 -0.6 -1.1 -0.8 -0.7 -0.6 -0.7 -1.0 0.7 -0.7 0.7 0.1 0.7 0.7 0.9 0.9 -0.7 -0.3 -0.8 -0.6 -0.7 -0.6 -0.7 -0.3 -0.6 -0.5 -1.1 -0.4 -0.8 -0.7 -0.8 -0.6
Eye problems/disorders: Glaucoma 0.8 1.0 2.7 1.1 1.6 1.2 1.1 1.1 1.0 0.8 -1.0 1.0 -1.1 1.0 -1.0 -1.0 0.0 -0.2 1.0 1.0 0.0 1.1 1.1 1.0 1.0 1.0 1.1 0.9 0.6 0.6 1.1 1.1 1.1 0.8
Medication: Blood pressure 0.1 0.3 2.4 -0.1 -0.7 0.1 -0.1 0.2 0.5 -0.4 0.1 -0.1 0.1 0.8 0.2 0.1 1.5 1.5 -0.1 0.5 1.1 0.0 0.1 -0.1 -0.1 -0.4 0.3 -0.4 -0.8 -0.3 -0.1 -0.1 0.1 -0.1
Pain type(s) experienced in last month: Hip pain 1.4 1.8 4.8 -1.3 -1.3 -1.5 -1.2 -1.2 -0.9 -1.5 1.2 -1.2 1.2 -2.2 1.3 1.2 -1.2 -1.5 -1.2 -1.4 -1.3 -1.4 -1.4 -1.3 -1.2 -1.6 -1.4 -1.3 -1.1 -1.1 -1.2 -1.2 -1.2 -1.6
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.5 -0.4 -0.2 -0.8 -0.7 -0.6 -0.4 -1.2 0.6 -0.7 0.8 -0.3 0.7 0.6 0.0 -0.4 -0.6 -0.2 -1.2 -0.6 -0.8 -0.6 -0.7 -0.3 -0.6 -0.5 0.5 -0.7 -0.6 -0.6 -0.6 -0.7
High cholesterol (Self-reported) 0.6 1.0 6.7 0.6 1.1 0.9 0.7 0.4 0.8 0.3 -0.7 0.7 -0.7 1.7 -0.7 -0.7 2.2 2.6 0.7 1.5 1.1 0.8 1.1 0.8 0.7 0.3 1.0 0.3 -0.6 0.3 0.8 0.7 0.9 1.0
Medication: Bendroflumethiazide 0.1 0.2 2.6 0.2 -0.5 -0.3 0.1 0.4 1.2 -0.7 -0.2 0.2 -0.1 -0.2 -0.1 -0.1 -0.8 -0.1 0.1 0.4 1.6 0.0 -0.2 0.1 0.2 -0.2 0.5 -0.1 -0.1 0.5 0.2 0.2 0.3 0.0
Medication: Paracetamol 0.7 1.0 2.1 -1.1 -1.0 -1.4 -1.1 -1.1 0.6 -1.0 1.0 -1.0 1.1 -1.1 1.0 1.0 0.0 0.4 -1.0 -1.0 -0.2 -1.1 -1.1 -1.0 -1.0 -1.2 -1.1 -1.1 -1.0 -1.4 -0.9 -1.1 -0.7 -1.2
Medication: Lisinopril 0.4 0.5 4.7 -0.2 0.2 -0.6 -0.3 -0.3 0.9 -1.6 0.3 -0.2 0.2 0.2 0.5 0.3 0.6 1.5 -0.3 0.4 -0.9 -0.3 -0.9 -0.3 -0.3 -0.4 0.0 -0.7 -2.2 -0.1 -0.2 -0.3 0.1 -0.1
Medication: Atorvastatin 1.2 1.5 4.9 1.1 1.3 1.9 1.2 1.0 1.0 0.4 -1.2 1.2 -1.1 1.4 -1.2 -1.2 2.2 1.2 1.2 1.6 0.7 1.2 1.3 1.2 1.2 0.6 1.4 0.6 0.7 0.5 1.3 1.2 1.5 1.0
Illnesses of father: High blood pressure 0.7 0.8 2.1 0.9 1.4 0.7 0.9 0.8 1.3 0.1 -0.9 0.8 -0.9 1.1 -0.8 -0.9 0.6 1.1 0.9 1.3 0.8 0.9 1.0 0.8 0.9 0.6 1.1 0.6 -0.2 0.9 1.0 0.9 1.0 0.9
Alcohol drinker status: Never 0.2 0.2 0.7 0.4 0.4 0.4 0.4 0.1 -0.5 0.3 -0.5 0.5 -0.3 0.9 -0.6 -0.5 0.4 -0.4 0.5 0.2 -0.8 0.5 0.3 0.5 0.5 0.0 0.4 0.5 0.0 0.4 0.6 0.5 0.5 0.6
Ever smoked 0.8 1.4 5.1 -1.0 -2.3 -1.6 -1.1 -0.8 -1.1 -0.0 1.2 -1.2 1.1 -1.2 1.2 1.2 -0.4 -0.3 -1.2 -1.4 0.5 -1.2 -1.3 -1.2 -1.2 -0.8 -1.5 -0.8 -0.4 -1.1 -1.4 -1.1 -1.5 -1.4
Basal metabolic rate 0.6 3.3 9.7 -1.5 -1.4 -2.1 -1.4 -2.1 -0.9 -2.6 1.5 -1.5 1.3 -2.8 1.3 1.5 -3.1 -2.8 -1.5 -1.6 -1.5 -1.8 -1.2 -1.6 -1.5 -2.6 -1.6 -1.8 -2.1 -1.6 -1.3 -1.3 -1.4 -1.8
Leg fat percentage (left) 0.1 0.2 0.9 -0.4 0.3 -0.4 -0.2 -0.9 0.8 -0.8 0.2 -0.1 0.2 -0.7 0.1 0.2 0.0 0.6 -0.2 -0.5 -1.0 -0.3 -0.4 -0.2 -0.2 -0.9 0.0 -0.3 -0.0 -0.3 0.1 -0.2 0.3 -0.1
Arm fat-free mass (left) 0.6 3.0 7.4 -1.5 -1.3 -2.0 -1.4 -2.0 -0.9 -2.5 1.5 -1.5 1.3 -2.7 1.3 1.5 -2.7 -2.4 -1.5 -1.4 -1.5 -1.8 -1.4 -1.6 -1.5 -2.4 -1.6 -1.8 -2.3 -1.5 -1.3 -1.3 -1.3 -1.7
Number of operations (self-reported) 0.1 0.1 0.5 -0.2 0.6 -0.4 -0.2 -0.0 0.0 -0.4 0.2 -0.2 0.4 -0.4 0.3 0.2 -0.7 -0.7 -0.2 -0.1 -0.2 -0.2 0.2 -0.2 -0.2 -0.1 -0.2 -0.1 -0.2 -0.3 -0.2 -0.2 -0.1 -0.2
Average weekly beer plus cider intake 3.9 5.7 11.3 -2.3 -2.2 -2.7 -2.2 -2.4 -1.8 -2.9 2.2 -2.2 2.1 -3.4 2.2 2.3 -2.5 -2.9 -2.3 -2.6 -3.1 -2.4 -2.2 -2.3 -2.3 -2.4 -2.4 -2.1 -1.1 -2.1 -2.2 -2.3 -2.4 -2.5
Irritability 4.8 8.1 11.9 2.9 2.4 2.8 2.9 3.2 3.5 2.5 -3.0 2.9 -3.0 3.3 -2.7 -3.0 1.9 1.9 3.0 2.8 2.0 3.0 3.4 3.0 3.0 3.0 2.9 3.1 1.3 2.6 2.9 3.0 3.1 2.8
Risk taking 0.6 0.8 2.4 1.0 0.3 0.3 1.0 1.2 1.6 1.1 -0.9 0.9 -1.0 0.6 -0.9 -0.9 -0.5 -0.0 0.9 0.9 1.4 0.8 0.5 0.9 0.9 1.3 0.7 0.9 -0.2 1.2 0.9 0.9 0.7 0.7
Ever had prostate specific antigen (PSA) test 0.2 0.3 1.1 0.7 -0.1 0.3 0.5 0.8 -0.2 -0.6 -0.6 0.6 -0.5 0.2 -0.3 -0.6 -0.2 0.1 0.6 1.1 0.3 0.5 0.3 0.5 0.5 0.8 0.8 0.5 0.3 0.3 0.6 0.5 0.5 0.5
Fractured/broken bones in last 5 years 1.5 2.0 7.9 1.3 0.8 1.7 1.2 2.0 1.2 2.0 -1.2 1.2 -1.2 1.8 -1.1 -1.2 -0.0 -0.2 1.2 1.3 2.8 1.4 0.9 1.3 1.2 1.9 1.2 1.3 0.8 2.0 1.1 1.3 1.2 1.3
Age started oral contraceptive pill 0.3 0.4 1.7 -0.8 -0.3 -0.2 -0.8 -0.8 0.2 0.3 0.7 -0.7 0.7 -0.0 0.7 0.7 0.6 1.3 -0.7 -0.8 -0.6 -0.6 -0.5 -0.7 -0.7 -0.4 -0.8 -0.8 -0.4 -0.4 -0.5 -0.7 -0.5 -0.1
Diastolic blood pressure, automated reading 2.2 6.9 12.2 2.4 2.8 2.9 2.3 2.5 3.1 2.6 -2.5 2.5 -2.3 3.5 -2.4 -2.5 3.1 2.9 2.5 2.8 3.1 2.6 2.7 2.6 2.5 2.4 2.7 2.4 1.5 2.1 2.5 2.5 2.8 2.6
Ever depressed for a whole week 0.2 0.2 0.6 0.3 0.8 0.7 0.3 0.4 0.5 0.6 -0.5 0.5 -0.4 -0.1 -0.5 -0.5 0.0 -0.8 0.5 0.3 0.4 0.4 0.6 0.4 0.5 0.6 0.4 0.2 -0.2 0.3 0.4 0.3 0.5 0.1
Unable to work because of sickness or disability 0.5 0.7 2.2 -0.8 -1.3 -1.4 -0.7 -0.9 -0.7 -1.3 0.7 -0.6 0.8 -1.1 0.6 0.7 0.4 0.0 -0.7 -0.7 -1.0 -0.7 -0.6 -0.6 -0.7 -0.8 -0.6 -0.5 -0.2 -1.5 -0.6 -0.8 -0.8 -1.2
Commuting to job workplace: Cycle 0.1 0.1 0.5 0.4 -0.5 -0.1 0.3 0.2 -0.1 0.6 -0.3 0.3 -0.3 0.3 -0.3 -0.3 0.5 0.7 0.3 0.1 -0.5 0.3 0.1 0.3 0.3 0.4 0.3 0.5 0.4 0.7 0.2 0.4 0.1 0.4
Myopia 0.2 0.2 1.6 -0.0 1.1 0.5 0.1 -0.5 0.6 -0.5 -0.1 0.1 0.1 0.3 -0.1 -0.1 1.2 1.1 0.1 0.4 -0.1 0.1 0.5 0.1 0.1 -0.4 0.3 -0.2 1.2 0.0 0.2 0.2 0.3 0.2
Vascular/heart problems diagnosed by doctor 0.6 1.6 4.3 -1.2 -0.7 -1.2 -1.2 -1.1 -1.3 -0.2 1.2 -1.1 1.2 -1.7 1.3 1.2 -2.0 -1.2 -1.2 -2.1 -1.5 -1.1 -1.2 -1.2 -1.2 -0.6 -1.6 -0.7 1.0 -1.0 -1.3 -1.2 -1.3 -1.2
Cholesterol lowering medication 0.5 0.7 5.4 0.4 0.2 0.7 0.6 0.4 0.6 0.0 -0.6 0.6 -0.6 1.4 -0.6 -0.5 1.8 2.3 0.5 1.2 0.9 0.7 1.3 0.6 0.6 0.2 0.8 0.3 -0.3 0.0 0.5 0.6 0.7 0.8
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 3.5 0.8 0.9 0.7 0.8 0.6 1.2 0.5 -0.9 0.9 -0.9 0.6 -0.9 -0.9 1.9 1.4 0.9 0.5 0.1 0.8 1.0 0.9 0.9 0.7 1.0 1.3 1.4 0.6 0.9 0.9 1.1 0.7
Pain experienced in last month 0.5 0.9 2.5 0.8 1.2 1.5 0.9 0.9 -0.5 0.7 -0.7 0.7 -0.8 1.3 -0.6 -0.7 1.0 1.6 0.7 1.2 0.4 0.9 0.8 0.8 0.8 1.2 1.0 0.8 0.5 0.4 0.8 0.9 0.8 1.3
Supplements: Calcium 0.1 0.1 2.4 -0.4 0.3 -0.1 -0.1 0.1 -0.0 -0.0 0.2 -0.2 0.2 0.4 0.3 0.2 -0.3 -0.1 -0.2 0.4 0.4 -0.1 -0.4 -0.2 -0.2 -0.1 -0.0 -0.5 -1.6 -0.1 -0.2 -0.3 -0.1 -0.1
Basal cell carcinoma (self-reported) 0.4 0.5 2.0 0.7 1.0 0.5 0.7 0.5 0.3 0.2 -0.6 0.6 -0.7 0.5 -0.5 -0.6 1.0 1.1 0.6 0.8 1.0 0.6 0.5 0.6 0.6 0.7 0.5 0.6 1.4 0.8 0.6 0.7 0.5 0.9
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.4 0.8 0.7 1.0 0.8 0.6 1.2 0.2 -0.7 0.7 -0.8 0.2 -0.7 -0.7 0.7 -0.1 0.7 0.8 -0.1 0.5 0.2 0.7 0.7 0.3 0.7 0.6 -0.0 0.8 0.8 0.7 0.8 0.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 2.6 0.2 -0.0 -0.3 0.2 -0.1 0.4 -0.3 -0.2 0.2 -0.2 -0.4 -0.4 -0.3 -0.9 -1.3 0.3 0.4 1.6 0.2 0.1 0.2 0.2 -0.2 0.3 -0.0 0.7 0.3 0.3 0.3 0.1 -0.1
Heart disease (siblings) 0.3 0.3 4.7 -0.1 0.1 0.2 -0.0 0.0 -0.2 -0.5 0.1 -0.1 0.1 -0.7 0.1 0.1 -2.1 -2.2 -0.1 -0.0 0.2 -0.1 0.2 -0.1 -0.1 -0.5 -0.2 -0.3 -0.3 -0.2 -0.2 -0.1 -0.1 -0.4
Alcohol drinker status: Previous 0.2 0.3 0.8 -0.6 0.5 0.0 -0.5 -0.9 -0.3 -0.6 0.5 -0.5 0.4 -0.5 0.4 0.5 -0.0 -0.4 -0.5 -0.4 -0.5 -0.5 -0.4 -0.5 -0.5 -0.5 -0.5 -0.6 0.0 -0.8 -0.5 -0.6 -0.4 -0.5
Pack years of smoking 0.2 0.2 0.9 0.3 -0.3 1.0 0.3 0.8 0.8 0.4 -0.4 0.4 -0.3 0.5 -0.3 -0.4 0.1 -0.0 0.4 0.3 -0.2 0.4 -0.1 0.4 0.4 0.9 0.5 0.4 -0.7 0.3 0.3 0.4 0.6 0.4
Impedance of whole body 1.1 5.4 10.2 2.1 1.2 2.5 2.3 3.2 1.1 3.0 -2.3 2.3 -2.2 2.6 -2.2 -2.3 2.5 1.5 2.3 2.1 2.3 2.5 2.1 2.4 2.3 3.2 2.4 2.5 2.6 2.5 2.0 2.2 1.9 2.3
Leg fat mass (left) 0.1 0.4 1.6 -0.5 0.1 -0.7 -0.4 -1.2 0.7 -1.1 0.3 -0.3 0.3 -1.1 0.2 0.3 -0.9 -0.2 -0.3 -0.7 -1.1 -0.6 -0.4 -0.4 -0.4 -1.3 -0.2 -0.5 -0.4 -0.5 -0.1 -0.3 0.1 -0.3
Arm predicted mass (left) 0.5 2.7 6.9 -1.4 -1.3 -1.9 -1.2 -1.9 -0.6 -2.5 1.4 -1.3 1.2 -2.6 1.2 1.4 -2.6 -2.4 -1.4 -1.3 -1.4 -1.7 -1.4 -1.4 -1.4 -2.3 -1.5 -1.7 -2.2 -1.3 -1.1 -1.2 -1.2 -1.6