Hub : Genes

RP11-316E14.6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Ovary	0.625	0.105	6.6e-04	-0.006	NA	0.105	NA	0.006	0.4700	NA	1.5e-03	NA	2.2e-01
2	GTEx	Spleen	0.248	0.161	5.6e-03	-0.009	NA	0.002	NA	-0.007	0.6300	NA	2.8e-01	NA	5.5e-01
3	GTEx	Whole Blood	0.235	0.065	2.0e-07	0.024	NA	0.076	NA	0.043	0.0025	NA	1.5e-07	NA	7.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.5	0.7	-0.8	0.4	-0.8
Bipolar Disorder or Schizophrenia	0.4	1.1	3.1	-0.1	0.3	-1.8
Depressed Affect (Nagel 2018)	2.9	6.2	11.1	2.5	-3.3	1.1
Depression (Nagel 2018)	0.2	0.3	0.8	-0.3	-0.9	0.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.7	-1.1	1.3	0.4
Neuroticism (Nagel 2018)	4.1	9.7	20.0	3.0	-4.5	0.5
Schizophrenia (2018)	0.5	1.1	3.1	0.2	0.1	-1.8
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	0.7	-0.2	0.2
Worry (Nagel 2018)	4.5	9.5	23.5	2.2	-4.8	-0.6
Alzheimer’s Disease (in mother)	0.4	0.5	1.3	-0.2	0.1	1.2
Alzheimer’s Disease (in father)	0.1	0.2	0.2	0.5	0.1	-0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	-0.3	0.5	1.0
Crohns Disease (2017)	0.3	0.6	1.2	-1.1	-0.5	0.6
Irritable Bowel Disease (IBD)	1.3	3.0	7.3	-2.7	0.2	-1.3
Ulcerative Colitis (UC)	2.6	4.9	8.2	-2.9	0.5	-2.5
Major Depression (MDD)	1.3	1.5	1.8	1.3	-1.1	-1.3
Reaction Time	2.5	4.7	5.4	-2.2	2.0	-2.3
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.5	-1.2	1.1	0.5
Breast Cancer	0.3	0.7	1.2	0.9	-0.1	1.1
Ovarian Cancer	0.6	0.8	1.4	-0.4	-1.2	-1.0
Prostate Cancer	1.9	2.7	5.4	1.6	-2.3	0.3
Age at First Birth	3.4	5.0	13.5	0.6	-1.1	3.7
Bipolar Disorder (2011)	3.5	3.3	6.1	2.5	1.1	1.6
Body Mass Index (BMI) (2010)	0.9	1.2	3.6	0.1	-0.0	-1.9
Coronary Artery Disease (CAD)	4.1	4.9	10.0	1.1	-3.2	1.9
Crohns Disease (2012)	0.6	1.0	3.0	-0.1	0.1	1.7
Mean Putamen Volume	0.3	0.3	0.7	-0.9	0.0	-0.5
Fasting Glucose	1.0	1.2	2.9	1.7	0.5	0.6
HbA1C	0.3	0.3	0.6	0.7	-0.1	-0.5
HDL Cholesterol	0.7	1.1	1.6	0.7	1.3	1.1
LDL Cholesterol	1.0	1.5	2.6	-1.6	1.4	0.2
Lupus	1.0	1.5	3.1	-0.4	-1.2	1.8
Neuroticism (2016)	1.9	2.8	7.0	2.7	-1.1	0.3
Primary Biliary Cirrhosis	1.0	1.4	1.8	-0.8	-1.3	1.3
Rheumatoid Arthritis	2.4	3.4	9.5	0.1	3.1	-0.7
Schizophrenia (2014)	0.6	1.4	3.9	2.0	-0.3	-0.5
Triglycerides	1.0	1.7	4.8	-0.3	-2.2	0.4
Type 2 Diabetes (T2D) (2012)	3.2	3.6	8.5	-0.9	1.3	-2.9
Ulcerative Colitis	1.0	1.5	2.1	-1.4	-0.6	-1.4
Blood Eosinophil Count	0.3	1.9	3.0	1.4	1.7	0.9
Blood Platelet Count	0.7	7.7	21.6	-1.1	4.7	-0.5
Blood Red Count	0.1	0.8	1.2	-1.1	0.9	-0.5
Blood White Count	0.3	2.0	5.8	0.1	2.4	-0.3
Heel T-Score	3.4	27.1	50.4	2.1	-7.1	5.1
BMI	0.3	1.8	4.7	-0.7	0.5	-2.2
Height	1.7	32.7	33.1	5.8	5.8	-5.7
Waist Hip Ratio (WHR)	1.7	7.6	22.8	0.2	-0.1	-4.8
Systolic Blood Pressure	3.1	15.7	46.1	-0.0	-6.8	-0.9
Smoking Status	0.4	0.9	2.7	1.6	-0.1	-0.1
Allergy or Eczema	0.3	0.8	1.2	0.6	0.8	-1.1
Cardiovascular Disease	1.4	4.5	6.5	1.4	-2.5	-2.2
Hypothyroidism (self reported)	3.1	7.0	18.7	1.3	-4.3	0.8
Respiratory disease	0.7	1.6	2.6	1.1	-1.0	-1.6
Type 2 Diabetes (T2D) (2018)	1.0	1.8	4.2	0.9	-0.6	-2.1
Lung FEV1/FVC ratio	1.3	6.8	9.1	-2.9	1.7	3.0
Lung FVC	1.5	7.6	21.9	-4.7	0.3	-0.8
Neuroticism	3.5	8.4	19.1	2.4	-4.4	-0.4
Chronotype (morning person)	1.4	3.2	5.9	2.4	1.2	1.5
Hair Pigment	0.0	0.8	1.5	-1.2	-0.9	0.4
Tanning	0.2	2.0	3.6	1.0	1.2	1.9
Hand grip strength (left)	2.9	7.5	13.2	3.6	-2.9	-0.9
Number of treatments/medications taken	2.7	4.9	9.9	1.4	-3.1	-1.6
Average weekly spirits intake	3.4	4.3	6.9	-1.1	2.2	-2.6
Sensitivity / hurt feelings	1.3	2.2	3.8	1.9	-1.5	0.7
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.1	1.0	-0.8	0.4
Hearing difficulty/problems: Yes	7.2	11.0	26.1	-0.5	2.5	-5.1
Relative age of first facial hair	0.2	0.4	0.6	0.3	0.8	-0.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.6	-0.4	-0.3	-1.3
Ever used hormone-replacement therapy (HRT)	0.9	1.2	1.9	0.1	-1.3	-1.4
Ever had hysterectomy (womb removed)	0.5	0.6	0.9	-0.9	0.5	0.9
Systolic blood pressure, automated reading	1.7	4.9	14.1	0.0	-3.8	-0.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.7	0.3	-0.8	-0.8
Angina	0.9	1.2	3.2	0.5	-1.8	-0.5
Medication for hormone replacement therapy	0.7	0.8	1.6	-0.8	-1.3	-0.1
Vitamin and mineral supplements	0.7	0.9	2.0	-1.4	-0.4	-0.7
Supplements: Zinc	0.7	0.7	2.0	-1.4	-0.1	-0.4
Medication: Co-codamol	0.4	0.4	0.8	0.7	-0.9	0.2
Medication: Metformin	1.8	2.6	6.5	0.3	-1.0	-2.5
Diabetes (father)	0.1	0.1	0.2	-0.1	-0.0	-0.5
Diabetes (mother)	0.3	0.3	0.5	-0.7	0.2	0.7
Severe depression (siblings)	0.7	0.7	2.1	0.4	-1.5	-0.1
Pack years adult smoking proportion	0.9	1.4	2.8	1.7	0.9	-0.9
Impedance of leg (right)	1.4	6.6	13.6	1.3	-3.7	-2.1
Leg fat-free mass (left)	1.1	6.1	10.0	1.0	3.2	-2.7
Trunk fat percentage	2.1	8.4	24.5	-0.6	-0.6	-5.0
Hand grip strength (right)	1.1	3.1	4.8	2.1	-2.2	-0.4
Townsend deprivation index at recruitment	1.0	1.4	2.6	1.2	-0.2	-1.6
Current tobacco smoking	1.3	2.1	4.9	2.2	1.2	-0.0
Average weekly fortified wine intake	0.7	0.8	1.6	-1.3	-0.8	0.3
Maternal smoking around birth	1.8	2.6	7.6	2.8	0.5	0.2
Fed-up feelings	4.0	7.3	16.0	2.1	-4.0	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.3	0.4	-0.5	-0.6
Relative age voice broke	0.6	0.9	2.4	1.6	0.2	-0.4
Taking other prescription medications	3.9	6.1	8.6	1.5	-2.9	-2.7
Age when periods started (menarche)	0.3	0.8	1.5	0.9	-0.4	1.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.9	-1.0	0.5	0.4
Heel bone mineral density (BMD) T-score, automated (left)	4.2	9.6	17.1	1.4	-4.1	3.1
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	2.4	-0.3	-0.6	-1.6
Qualifications: CSEs or equivalent	0.0	0.0	0.1	-0.2	-0.3	-0.0
Serious illness, injury or assault to yourself	0.8	1.0	1.2	-0.8	1.1	-1.1
High blood pressure	0.4	1.1	2.6	0.2	-0.9	-1.6
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.9	0.4	1.1	-1.4
Multivitamins +/- minerals	0.6	0.8	2.3	1.5	0.1	0.4
Stomach or abdominal pain in last month	0.4	0.6	0.9	0.9	-0.8	-0.4
Supplements: Glucosamine	0.0	0.0	0.0	-0.1	-0.1	-0.2
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.9	-0.6	1.4	-0.7
Medication: Atenolol	2.5	3.1	9.1	-0.3	-3.0	-0.4
Medication: Levothyroxine sodium	2.5	4.2	10.9	1.3	-3.3	-0.2
Sitting height	0.1	0.6	1.2	1.1	-0.2	-0.7
Chronic bronchitis/emphysema (father)	0.8	1.0	1.5	1.2	1.0	0.7
High blood pressure (mother)	3.2	4.4	10.5	-3.2	-1.0	-1.4
Body mass index (BMI)	0.3	1.3	2.5	-0.9	0.6	-1.6
Impedance of leg (left)	1.5	7.3	15.8	1.4	-4.0	-2.0
Leg predicted mass (left)	1.1	5.7	9.7	1.0	3.1	-2.6
Trunk fat mass	1.9	8.3	24.6	0.0	0.4	-5.0
Waist circumference	1.9	7.0	17.9	-0.6	1.7	-4.2
Number of incorrect matches in round	0.6	0.9	2.1	-1.5	-0.2	0.7
Past tobacco smoking	0.5	0.9	2.1	-0.7	1.5	-0.3
Alcohol usually taken with meals	1.0	1.6	2.4	-1.0	1.5	-1.2
Nervous feelings	3.3	6.2	12.5	2.3	-3.5	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	2.7	1.2	-0.6	-1.6
Hearing difficulty/problems with background noise	2.5	4.1	9.3	-0.0	1.7	-3.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.7	-0.4	-0.1	-1.3
Had menopause	0.9	1.1	2.2	1.5	0.5	-0.9
Had other major operations	3.1	3.7	8.1	2.9	1.4	-1.0
Forced vital capacity (FVC)	0.5	2.1	4.5	-0.6	1.2	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	3.4	7.9	12.6	1.3	-3.5	3.1
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	5.3	0.9	-2.3	0.4
Qualifications: None of the above	0.8	1.8	4.7	0.7	0.3	-2.2
Financial difficulties in last 2 years	1.3	1.8	1.9	1.4	1.4	1.2
Mouth/teeth dental problems	0.1	0.2	0.3	0.6	-0.5	0.1
Heart attack	1.8	2.3	3.8	2.0	-1.7	0.3
Allergy	1.5	3.5	7.3	-1.2	-1.3	2.7
Pain all over the body in last month	0.3	0.4	0.8	-0.5	0.4	-0.9
Diabetes (self-reported)	1.0	1.5	2.6	0.2	-1.4	-1.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.3	-0.4	0.2	-1.1
Medication: Ramipril	1.0	1.3	1.6	1.1	-1.3	-1.2
Medication: Simvastatin	0.4	0.6	1.8	-0.2	-1.4	0.0
Fluid intelligence score	0.1	0.2	0.3	-0.5	-0.4	0.3
Illnesses of siblings	1.7	2.4	4.8	1.4	0.8	2.2
Neuroticism score	3.3	6.9	11.9	2.9	-3.4	-0.4
Weight	1.3	6.6	15.5	0.4	2.0	-3.9
Impedance of arm (right)	0.8	3.6	10.3	0.4	-0.6	-3.2
Arm fat percentage (right)	1.3	5.0	13.3	-1.1	0.6	-3.6
Trunk fat-free mass	0.9	5.2	10.8	1.5	3.3	-1.6
Hip circumference	1.4	6.2	12.7	-0.3	2.4	-3.6
Time employed in main current job	0.6	0.7	1.0	-0.4	-1.0	-1.0
Alcohol intake versus 10 years previously	2.2	3.3	5.2	-0.8	2.3	-2.1
Father’s age at death	1.2	1.6	1.9	-1.4	1.3	-1.0
Worrier / anxious feelings	2.9	5.5	12.9	1.7	-3.6	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.7	1.3	0.9	-0.8
Falls in the last year	2.4	3.2	6.7	0.7	1.6	-2.6
Hair/balding pattern: Pattern 3	0.8	1.3	3.4	1.8	0.2	0.6
Number of live births	0.2	0.4	0.7	0.9	0.6	-0.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	2.3	-1.5	1.3	-1.1
Pulse rate	0.4	0.7	1.3	-0.3	0.8	1.2
Happiness	1.0	1.3	2.6	1.6	-0.9	0.7
Noisy workplace	0.5	0.6	1.6	0.4	1.3	0.3
Qualifications: A levels/AS levels or equivalent	1.3	2.8	4.5	-1.9	0.7	2.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.2	-0.8	1.5	0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	0.0	0.7	-0.2
Asthma	1.1	2.2	3.5	1.6	-0.7	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.7	0.5	-0.1	-1.3
Medication: Cholesterol lowering	0.4	0.6	0.9	-0.1	-1.0	-0.9
Depression (self-reported)	0.8	0.9	2.6	1.6	-0.2	0.3
Medication: Lansoprazole	0.3	0.3	0.7	-0.4	-0.9	-0.2
Prospective memory result	0.9	1.1	2.4	-1.5	0.4	-0.8
Lung cancer (father)	0.6	0.7	1.9	1.4	0.0	0.3
Illnesses of mother	0.6	0.7	1.2	0.7	1.1	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	4.6	-2.1	1.4	-0.7
Pulse wave Arterial Stiffness index	0.7	0.8	2.1	-1.4	0.5	-0.1
Impedance of arm (left)	0.5	2.2	6.0	0.3	-0.8	-2.4
Arm fat mass (right)	0.9	3.9	10.7	0.2	1.0	-3.3
Trunk predicted mass	0.9	5.2	10.4	1.6	3.2	-1.6
Standing height	1.6	15.7	24.8	3.1	3.5	-5.0
Length of working week for main job	0.9	1.0	2.7	1.7	-0.2	0.6
Exposure to tobacco smoke at home	1.1	1.2	2.7	-0.4	0.9	-1.6
Breastfed as a baby	0.2	0.2	0.4	0.6	0.5	-0.3
Tense / ‘highly strung’	2.1	3.5	7.6	0.1	-1.7	-2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	5.6	2.4	-1.3	-1.9
Hair/balding pattern: Pattern 4	1.0	2.3	4.5	-1.3	2.1	1.0
Birth weight of first child	1.4	2.5	3.3	-1.6	1.8	-1.2
Peak expiratory flow (PEF)	0.3	0.8	2.1	0.1	-1.5	0.4
Pulse wave reflection index	0.8	1.0	1.5	-1.2	1.2	0.4
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.0	1.4	-1.0	-0.9
Loud music exposure frequency	0.5	0.6	1.2	1.1	0.6	-0.5
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	5.9	-1.5	-0.2	2.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.3	-0.6	-0.0
Blood clot in the leg (DVT)	0.6	0.7	1.5	-0.1	1.2	-0.8
Medication: Paracetamol	0.3	0.5	0.9	0.9	-0.5	-0.5
Headache pain in last month	0.5	0.8	2.2	1.5	-0.4	0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.1	-0.3	0.9	1.0
Glaucoma (self-reported)	0.9	1.1	2.9	-0.6	-0.2	-1.7
Gout (self-reported)	0.5	0.7	1.0	1.0	-0.9	0.6
Hypothyroidism/myxoedema (self-reported)	2.9	5.6	13.6	1.8	-3.7	0.4
Medication: Amlodipine	2.1	3.0	4.4	-0.5	-2.1	2.1
Medication: Ventolin 100micrograms inhaler	1.3	1.7	4.6	2.1	-0.3	0.5
Birth weight	1.2	2.6	5.7	2.4	-0.7	1.2
Chronic bronchitis/emphysema (mother)	1.5	1.7	4.9	2.2	0.5	-0.0
High blood pressure (siblings)	0.1	0.1	0.4	0.1	-0.6	-0.0
Forced vital capacity (FVC), Best measure	0.8	3.0	4.6	-1.3	1.7	-2.1
Body fat percentage	1.8	7.0	20.0	-0.6	-0.9	-4.5
Leg fat percentage (right)	1.3	4.6	10.8	-0.3	-1.7	-3.3
Arm fat-free mass (right)	0.5	2.8	4.2	1.6	2.1	-1.3
Exposure to tobacco smoke outside home	2.6	3.5	5.9	2.4	-0.8	-2.0
Comparative body size at age 10	1.1	3.0	7.1	-2.7	1.2	0.6
Number of full brothers	0.0	0.1	0.1	-0.3	0.1	0.3
Worry too long after embarrassment	0.9	1.5	3.8	2.0	-0.7	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.0	1.4	0.1	-1.1
Wheeze or whistling in the chest in last year	1.3	2.3	5.4	1.1	-0.6	-2.3
Number of children fathered	0.2	0.3	0.4	-0.6	-0.6	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.6	-1.3	-0.7	-0.2
Age at first live birth	0.7	1.3	2.9	-0.4	1.0	1.7
Pulse wave peak to peak time	1.1	1.3	3.4	1.9	-0.5	-0.3
Health satisfaction	0.7	0.9	1.5	-1.2	0.4	-1.0
Shortness of breath walking on level ground	1.4	1.7	2.1	-1.2	-1.2	-1.5
Qualifications: College or University degree	0.5	1.5	3.9	-0.7	0.4	2.0
Eye problems/disorders: None of the above	0.8	0.9	2.5	1.6	-0.4	-0.0
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.5	-0.2	0.7	0.7
Emphysema/chronic bronchitis	1.1	1.2	2.3	1.0	1.5	-0.6
Medication for pain relief, constipation, heartburn	1.1	1.8	3.3	-1.0	1.0	1.8
Neck or shoulder pain in last month	0.9	1.2	2.9	-0.2	0.9	-1.7
Medication: Blood pressure	0.6	1.0	2.8	0.5	-1.7	-0.3
Angina (self-reported)	0.8	1.1	2.8	0.4	-1.7	-0.5
Migraine (self-reported)	1.1	1.4	2.4	0.8	-1.5	1.0
Medication: Ibuprofen	0.4	0.4	1.1	0.4	0.3	-1.1
Medication: Allopurinol	1.1	1.5	2.2	0.6	-1.5	1.4
Medication: Omeprazole	1.3	1.6	2.3	1.1	-1.0	1.5
Medication: Seretide 50 evohaler	1.0	1.2	3.5	1.9	-0.1	0.0
Mean time to correctly identify matches	2.2	4.3	6.9	-1.8	2.6	-1.6
Heart disease (mother)	2.7	3.3	6.2	0.6	-2.5	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.2	0.9	-0.4	-1.1
Whole body fat mass	1.5	6.4	19.0	0.2	0.4	-4.4
Leg fat mass (right)	1.2	4.6	13.7	0.4	0.1	-3.7
Arm predicted mass (right)	0.5	2.8	3.5	1.7	1.9	-1.4
Pulse rate, automated reading	0.0	0.1	0.3	-0.5	-0.1	-0.3
Alcohol intake frequency.	1.8	4.2	10.0	0.3	1.5	-3.2
Comparative height size at age 10	2.1	11.8	20.3	0.8	3.8	-4.5
Number of full sisters	1.8	2.2	3.5	1.8	0.0	1.9
Suffer from ‘nerves’	3.5	5.5	9.4	2.7	-3.1	0.3
Overall health rating	0.5	1.0	3.0	0.3	0.2	-1.7
Chest pain or discomfort	1.9	2.7	8.0	0.2	0.3	-2.8
Had major operations	1.0	1.2	2.3	-0.6	-0.9	1.5
Age at last live birth	0.7	1.0	1.8	0.5	1.3	1.0
Family relationship satisfaction	0.5	0.6	0.9	0.3	-1.0	-0.8
Leg pain on walking	0.6	0.7	1.3	1.2	-0.1	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	1.0	-0.5	0.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.1	-1.5	0.4	-0.3
Illness, injury, bereavement, stress in last 2 years	2.9	3.5	5.3	1.6	-2.3	1.7
Medication: Aspirin	1.5	1.9	2.9	-0.3	-1.7	-1.7
Supplements: Vitamin C	1.9	2.2	4.2	1.5	2.1	0.3
Knee pain experienced in last month	1.7	2.6	4.7	0.7	1.7	-2.2
Hypertension (Self-reported)	0.6	1.8	3.8	-0.1	-1.3	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	2.9	0.2	-1.7	0.9
Illnesses of father: Heart disease	0.4	0.6	0.7	0.6	-0.9	0.8
Illnesses of siblings: Diabetes	0.6	0.7	1.0	-1.0	-0.4	-1.0
Smoking status: Previous	0.9	1.4	4.2	0.0	-2.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.8	2.2	1.5	1.3	-1.2
Whole body fat-free mass	0.9	5.2	9.9	1.3	3.1	-2.0
Leg fat-free mass (right)	1.1	5.8	10.8	1.0	3.3	-2.4
Arm fat percentage (left)	0.9	3.5	9.6	-0.9	0.3	-3.1
Average weekly red wine intake	1.5	2.2	4.4	-2.1	0.9	1.2
Handedness (chirality/laterality): Left-handed	2.0	2.4	5.3	1.1	2.3	-0.8
Mood swings	3.3	5.9	9.8	3.1	-2.8	0.4
Loneliness, isolation	1.1	1.5	2.3	1.2	-1.5	0.8
Long-standing illness, disability or infirmity	0.5	0.7	1.9	0.1	-0.5	-1.4
Ever had bowel cancer screening	0.3	0.3	0.7	-0.8	-0.5	-0.0
Diabetes diagnosed by doctor	0.9	1.5	3.4	-0.4	-1.0	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.9	4.4	2.1	-1.0	-0.2
Friendships satisfaction	0.3	0.4	0.6	0.8	-0.6	-0.2
Qualifications: nursing, teaching	1.7	2.6	6.6	-0.8	0.7	2.6
Commuting to job workplace: Walk	1.8	2.0	4.0	2.0	-1.4	-0.3
Eye problems/disorders: Cataract	1.6	1.9	3.8	-1.3	2.0	0.3
Mouth/teeth dental problems: Mouth ulcers	2.7	4.3	10.8	-0.2	3.3	-1.4
Medication for cholesterol	2.9	4.3	6.0	2.4	2.3	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	0.6	0.3	-0.3
Back pain experienced in last month	0.8	1.2	2.6	0.4	-1.6	0.9
Mineral and other dietary supplements	0.5	0.7	1.3	0.1	-1.2	0.9
Breast cancer (self-reported)	0.7	0.8	2.3	-1.5	0.1	-0.4
Asthma (self-reported)	1.2	2.4	3.6	1.8	-0.7	-1.9
Osteoporosis (self-reported)	1.3	1.6	2.5	0.2	1.5	-1.6
Osteoarthritis (self-reported)	0.7	0.9	1.5	-1.2	1.0	-0.6
Medication: Aspirin	1.2	1.5	3.6	-0.2	-1.0	-1.9
Medication: Gliclazide	1.2	1.4	3.6	0.1	-0.7	-1.9
Illnesses of father: None of the above (group 1)	1.4	1.8	3.6	-1.2	1.9	0.5
Smoking status: Current	1.1	1.7	3.4	1.8	1.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	5.0	11.7	-3.4	-0.2	1.8
Whole body water mass	0.9	5.0	9.7	1.4	3.1	-1.8
Leg predicted mass (right)	1.1	5.9	11.2	1.0	3.3	-2.4
Arm fat mass (left)	0.9	3.7	9.9	-0.0	1.1	-3.1
Number of self-reported non-cancer illnesses	1.0	1.7	3.0	1.3	-0.6	-1.7
Average weekly champagne plus white wine intake	2.1	2.8	4.4	0.7	-1.9	2.1
Miserableness	0.9	1.6	2.5	1.4	-1.6	0.4
Guilty feelings	3.4	5.1	8.9	3.0	-2.5	-0.2
Wears glasses or contact lenses	0.2	0.2	0.4	0.1	0.4	0.6
Ever taken oral contraceptive pill	1.1	1.2	3.0	-0.4	-1.7	0.7
Hearing aid user	4.2	4.8	7.4	-0.8	2.7	-2.5
Mother’s age at death	0.9	1.2	3.4	-1.8	0.0	-0.3
Financial situation satisfaction	2.6	3.2	7.7	2.8	-0.7	1.2
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.0	-1.0	0.5	-1.7
Commuting to job workplace: Public transport	1.3	1.5	2.4	1.1	1.0	1.5
Eye problems/disorders: Glaucoma	0.8	1.0	1.8	-0.2	-1.1	-1.3
Medication: Blood pressure	1.3	2.5	4.1	-1.5	-2.0	-1.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.4	0.6	-0.4	0.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.9	-0.5	1.4	-0.4
High cholesterol (Self-reported)	0.7	1.2	1.8	1.4	-0.7	-1.1
Medication: Bendroflumethiazide	3.0	4.6	6.9	-2.6	-1.2	-2.3
Medication: Paracetamol	0.3	0.5	0.9	1.0	-0.7	-0.2
Medication: Lisinopril	0.2	0.3	0.7	-0.2	-0.9	-0.0
Medication: Atorvastatin	0.9	1.1	1.4	0.9	-1.0	-1.2
Illnesses of father: High blood pressure	2.3	2.8	6.1	-0.9	-2.5	-1.3
Alcohol drinker status: Never	1.3	1.6	2.7	1.6	-0.1	-1.4
Ever smoked	0.9	1.5	3.2	1.8	-1.1	0.4
Basal metabolic rate	1.0	5.6	8.5	1.2	2.9	-2.6
Leg fat percentage (left)	1.1	4.0	8.9	-0.2	-1.7	-3.0
Arm fat-free mass (left)	0.8	4.1	5.3	1.3	2.3	-2.3
Number of operations (self-reported)	0.3	0.4	0.8	0.9	0.3	-0.5
Average weekly beer plus cider intake	1.7	2.5	4.8	2.2	-0.7	-1.5
Irritability	0.9	1.6	2.4	0.8	-1.3	-1.5
Risk taking	0.7	1.1	1.2	1.1	1.1	0.9
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.3	-1.1	0.8	-0.1
Fractured/broken bones in last 5 years	2.5	3.3	5.1	-1.2	2.3	-1.8
Age started oral contraceptive pill	1.2	1.5	3.7	-0.3	1.9	-0.9
Diastolic blood pressure, automated reading	1.1	3.3	8.8	-0.2	-3.0	-1.0
Ever depressed for a whole week	3.6	4.4	9.8	3.1	-1.5	1.2
Unable to work because of sickness or disability	0.9	1.2	2.5	0.7	1.6	-0.8
Commuting to job workplace: Cycle	1.1	1.4	3.3	0.4	-0.8	1.8
Myopia	0.1	0.2	0.4	-0.3	-0.7	0.2
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.0	-0.5	0.9	1.7
Cholesterol lowering medication	0.2	0.4	0.6	0.0	-0.7	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.3	1.1	-0.2	1.2
Pain experienced in last month	0.4	0.7	1.1	-0.8	-0.6	1.1
Supplements: Calcium	0.5	0.5	1.0	-0.8	-0.1	-1.0
Basal cell carcinoma (self-reported)	1.1	1.4	2.4	-1.0	0.8	-1.6
Heart attack/myocardial infarction (self-reported)	1.7	2.2	3.9	2.0	-1.7	0.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.4	-0.1	1.2	-0.6
Heart disease (siblings)	2.3	2.8	4.4	-2.1	-1.8	-0.8
Alcohol drinker status: Previous	0.2	0.3	0.5	0.3	-0.7	0.4
Pack years of smoking	0.8	1.2	1.3	1.0	1.1	-1.1
Impedance of whole body	0.9	4.7	7.1	0.8	-2.7	-2.5
Leg fat mass (left)	1.1	4.2	12.3	0.5	0.3	-3.5
Arm predicted mass (left)	0.7	3.5	4.7	1.5	2.2	-1.9