Hub : Genes

RP11-317J10.2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Hypothalamus 0.3310 0.117 0.00059 0.046 NA 0.148 NA 0.104 3.1e-02 NA 2.6e-04 NA 2.0e-03
2 GTEx Brain Putamen basal ganglia 0.2450 0.097 0.00046 0.219 NA 0.182 NA 0.201 6.3e-06 NA 4.2e-05 NA 1.6e-05
3 GTEx Colon Transverse 0.1040 0.046 0.00020 0.117 NA 0.075 NA 0.093 3.4e-06 NA 1.9e-04 NA 3.6e-05
4 GTEx Muscle Skeletal 0.0697 0.039 0.00300 0.002 NA 0.003 NA 0.007 2.1e-01 NA 1.6e-01 NA 6.6e-02
5 GTEx Prostate 0.2430 0.100 0.00190 0.022 NA 0.020 NA 0.016 9.3e-02 NA 1.0e-01 NA 1.3e-01
6 GTEx Testis 0.0680 0.038 0.00790 0.005 NA 0.004 NA 0.004 1.9e-01 NA 2.0e-01 NA 1.9e-01
7 GTEx Thyroid 0.0490 0.027 0.00062 0.018 NA 0.027 NA 0.027 1.4e-02 NA 3.5e-03 NA 3.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.3 0.5 1.5 0.6 -0.2 -0.2 1.2 0.0 1.2 -0.1
Bipolar Disorder or Schizophrenia 0.1 0.3 1.2 0.4 -0.3 -0.4 1.1 0.0 0.1 -0.3
Depressed Affect (Nagel 2018) 0.1 0.3 1.3 -0.3 -0.6 -0.4 -0.2 0.0 1.1 -0.0
Depression (Nagel 2018) 0.2 0.3 0.4 0.7 0.5 0.7 -0.6 0.0 0.1 0.6
Intelligence (Savage-Jansen 2018) 1.2 3.7 9.5 0.3 2.2 2.1 -0.8 0.0 -2.6 3.1
Neuroticism (Nagel 2018) 0.5 1.2 2.7 0.7 0.9 1.1 -1.6 0.0 1.2 1.3
Schizophrenia (2018) 0.1 0.2 0.8 0.1 -0.2 -0.3 0.5 0.0 -0.9 -0.3
Schizophrenia vs Biploar Disorder 0.4 0.5 1.6 -1.2 -0.7 -0.9 0.9 0.0 -0.2 -0.5
Worry (Nagel 2018) 1.2 2.5 4.8 1.1 1.8 2.1 -2.2 0.0 -0.3 1.9
Alzheimer’s Disease (in mother) 1.2 1.4 1.9 1.4 1.2 1.3 -1.2 0.0 -1.1 1.3
Alzheimer’s Disease (in father) 2.9 3.1 6.2 1.3 2.1 2.0 -1.3 0.0 -2.5 2.0
Alzheimer’s Disease (including proxy) 3.3 4.8 7.2 1.6 2.5 2.6 -2.1 0.0 -2.4 2.7
Crohns Disease (2017) 4.5 9.8 15.0 -2.6 -3.9 -3.8 3.0 0.0 3.5 -3.4
Irritable Bowel Disease (IBD) 1.7 4.1 7.1 -1.7 -2.5 -2.2 1.5 0.0 2.7 -2.3
Ulcerative Colitis (UC) 0.0 0.1 0.2 0.0 -0.4 -0.1 0.1 0.0 0.3 -0.5
Major Depression (MDD) 0.2 0.2 0.8 -0.1 0.2 0.3 -0.9 0.0 0.8 -0.1
Reaction Time 0.5 1.0 3.7 -1.9 -1.2 -1.0 -0.1 0.0 1.0 -0.3
Verbal and Numeric Reasoning (VNR) 0.4 1.0 3.1 0.5 1.1 1.0 0.1 0.0 -1.2 1.8
Breast Cancer 0.4 0.9 1.5 0.8 1.1 1.2 -1.0 0.0 -1.2 0.7
Ovarian Cancer 0.5 0.6 2.3 0.2 0.8 0.7 -0.8 0.0 -1.5 0.5
Prostate Cancer 0.6 0.8 2.2 -1.1 -1.1 -0.9 0.1 0.0 0.5 -1.5
Age at First Birth 2.4 3.5 7.6 2.2 2.3 2.0 -1.0 0.0 -1.4 2.8
Bipolar Disorder (2011) 0.3 0.3 1.1 0.3 -0.5 -0.5 0.7 0.0 0.4 -1.1
Body Mass Index (BMI) (2010) 0.3 0.4 1.6 0.2 0.1 0.3 -0.8 0.0 1.3 0.7
Coronary Artery Disease (CAD) 0.3 0.3 0.8 -0.9 -0.5 -0.1 -0.9 0.0 0.4 0.5
Crohns Disease (2012) 2.2 3.6 7.2 -1.1 -2.1 -2.3 2.7 0.0 1.4 -2.3
Mean Putamen Volume 0.1 0.1 0.4 -0.2 0.1 0.2 -0.1 0.0 -0.2 0.6
Fasting Glucose 0.2 0.3 1.7 0.0 -0.0 -0.2 1.3 0.0 0.2 0.5
HbA1C 0.0 0.1 0.2 0.2 0.3 0.3 0.0 0.0 0.4 0.1
HDL Cholesterol 0.9 1.5 3.5 -0.3 1.3 1.2 -0.7 0.0 -1.8 1.9
LDL Cholesterol 1.4 2.2 9.3 -0.1 1.5 1.5 -0.8 0.0 -3.1 0.7
Lupus 0.6 0.9 1.9 0.7 1.4 1.0 0.4 0.0 -1.4 0.9
Neuroticism (2016) 0.7 1.0 2.0 1.4 1.2 1.2 -0.3 0.0 -0.2 1.3
Primary Biliary Cirrhosis 0.3 0.4 1.4 0.5 0.6 0.7 0.4 0.0 -0.0 1.2
Rheumatoid Arthritis 0.3 0.4 0.8 -0.9 -0.8 -0.8 0.4 0.0 0.0 -0.9
Schizophrenia (2014) 0.1 0.2 0.9 0.2 -0.2 -0.4 0.7 0.0 -0.9 -0.3
Triglycerides 0.1 0.2 0.5 -0.3 -0.6 -0.5 -0.2 0.0 0.3 -0.7
Type 2 Diabetes (T2D) (2012) 1.5 1.8 5.9 2.4 1.6 1.3 0.9 0.0 -0.6 1.2
Ulcerative Colitis 0.2 0.3 0.8 0.9 0.3 0.5 0.0 0.0 0.7 -0.5
Blood Eosinophil Count 0.0 0.3 0.9 -0.6 -0.4 -0.3 -0.3 0.0 1.0 -0.5
Blood Platelet Count 0.2 2.8 5.9 -0.6 -2.0 -2.1 1.7 0.0 2.4 -1.3
Blood Red Count 0.1 0.8 2.2 -0.4 0.8 0.8 -0.5 0.0 -1.5 1.3
Blood White Count 0.5 4.1 7.4 -2.3 -2.7 -2.5 -0.1 0.0 2.6 -1.6
Heel T-Score 0.1 0.6 2.2 -1.5 0.2 0.2 -0.0 0.0 -1.4 -0.5
BMI 0.7 4.3 12.8 -3.6 -2.5 -2.5 -0.4 0.0 1.8 -1.2
Height 0.1 2.0 3.8 1.8 1.9 1.9 -0.8 0.0 -1.6 0.4
Waist Hip Ratio (WHR) 0.6 2.8 5.0 2.2 2.2 2.1 -0.1 0.0 -0.8 2.2
Systolic Blood Pressure 0.3 1.3 3.1 -0.9 -1.5 -1.8 1.4 0.0 0.8 -0.1
Smoking Status 0.9 2.0 3.4 -1.8 -1.8 -1.8 1.1 0.0 0.0 -1.8
Allergy or Eczema 0.1 0.3 1.0 -0.5 -0.0 0.2 -0.3 0.0 1.0 0.9
Cardiovascular Disease 0.1 0.4 0.7 -0.6 -0.7 -0.8 0.7 0.0 0.4 0.5
Hypothyroidism (self reported) 0.1 0.2 0.3 0.5 0.6 0.6 -0.5 0.0 0.3 0.4
Respiratory disease 0.7 1.5 5.9 0.4 0.9 1.2 -2.4 0.0 -0.1 1.5
Type 2 Diabetes (T2D) (2018) 0.9 1.7 4.7 1.0 1.5 1.5 -0.1 0.0 -1.3 2.2
Lung FEV1/FVC ratio 0.2 1.0 2.9 1.3 1.0 1.1 -0.3 0.0 0.3 1.7
Lung FVC 5.8 29.3 49.1 -6.5 -7.0 -6.7 4.5 0.0 4.4 -5.4
Neuroticism 1.1 2.7 7.2 1.1 1.6 2.1 -2.7 0.0 0.2 1.9
Chronotype (morning person) 1.1 2.6 11.4 -3.4 -1.4 -1.5 -0.0 0.0 1.4 -0.8
Hair Pigment 0.0 0.9 2.8 1.7 1.2 1.3 -0.5 0.0 0.2 0.4
Tanning 0.0 0.3 1.2 -0.4 0.4 0.4 -1.1 0.0 -0.2 -0.6
Hand grip strength (left) 3.0 7.8 13.8 -3.5 -3.5 -3.7 2.2 0.0 2.4 -2.4
Number of treatments/medications taken 0.1 0.2 0.7 0.5 0.2 0.3 -0.8 0.0 0.5 0.5
Average weekly spirits intake 0.2 0.2 0.9 0.0 0.3 0.3 -0.4 0.0 -1.0 -0.6
Sensitivity / hurt feelings 0.5 0.9 4.0 -0.6 -0.2 0.2 -1.3 0.0 2.0 0.1
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.5 -0.5 0.1 0.2 0.7 0.0 -0.6 0.4
Hearing difficulty/problems: Yes 0.5 0.7 1.6 -0.9 -0.7 -0.8 1.3 0.0 0.9 -0.7
Relative age of first facial hair 0.1 0.3 1.7 -0.2 0.1 -0.1 -0.2 0.0 1.3 0.2
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.5 -0.6 0.8 0.6 -0.1 0.0 -1.4 1.6
Ever used hormone-replacement therapy (HRT) 1.6 2.1 5.0 0.3 -1.7 -1.6 1.2 0.0 2.2 -1.6
Ever had hysterectomy (womb removed) 0.3 0.3 1.1 0.2 -0.7 -0.4 -0.7 0.0 -0.2 -1.0
Systolic blood pressure, automated reading 0.6 1.9 4.7 -2.2 -1.9 -1.9 0.4 0.0 0.6 -1.0
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 6.9 2.6 1.7 1.4 0.8 0.0 -0.6 0.7
Angina 0.8 1.1 4.0 -0.3 -1.2 -1.2 0.8 0.0 2.0 -0.2
Medication for hormone replacement therapy 0.7 0.8 2.3 0.7 0.7 0.7 -1.4 0.0 -0.2 1.5
Vitamin and mineral supplements 1.4 1.8 5.4 -2.3 -1.5 -1.2 0.6 0.0 1.2 -1.4
Supplements: Zinc 0.6 0.7 2.6 -0.1 0.6 0.5 0.6 0.0 -1.6 1.1
Medication: Co-codamol 0.5 0.6 2.9 0.2 -0.1 0.2 -1.7 0.0 1.0 -0.0
Medication: Metformin 0.3 0.4 1.0 -0.1 0.2 0.3 1.0 0.0 -0.8 1.0
Diabetes (father) 0.6 0.7 2.1 0.4 0.7 0.6 1.4 0.0 -1.4 -0.1
Diabetes (mother) 0.8 1.0 1.8 0.6 1.3 1.3 -1.1 0.0 -1.2 0.8
Severe depression (siblings) 0.6 0.7 1.7 1.1 1.1 1.3 -0.0 0.0 -0.1 0.6
Pack years adult smoking proportion 0.4 0.7 2.8 -0.7 -0.8 -0.5 -0.6 0.0 -0.5 -1.7
Impedance of leg (right) 0.2 1.1 3.8 2.0 0.4 0.6 1.4 0.0 1.2 -0.2
Leg fat-free mass (left) 0.1 0.6 3.0 -1.7 -0.3 -0.4 -0.8 0.0 -0.4 -0.0
Trunk fat percentage 0.2 0.7 3.4 -1.9 -0.6 -0.5 -0.1 0.0 0.9 -0.2
Hand grip strength (right) 4.7 12.8 23.1 -4.8 -4.5 -4.5 2.6 0.0 2.9 -3.1
Townsend deprivation index at recruitment 0.3 0.5 2.6 -1.6 -0.5 -0.4 0.1 0.0 -0.5 -0.1
Current tobacco smoking 1.1 1.8 5.9 -0.7 -1.6 -1.4 0.2 0.0 1.1 -2.4
Average weekly fortified wine intake 1.7 2.0 3.5 1.6 1.4 1.6 -1.3 0.0 -1.9 1.3
Maternal smoking around birth 0.5 0.8 3.2 -0.1 0.6 0.5 0.6 0.0 -1.8 1.0
Fed-up feelings 0.1 0.2 0.4 0.3 -0.5 -0.5 0.4 0.0 0.6 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.6 0.1 0.9 0.9 -0.3 0.0 -1.3 1.0
Relative age voice broke 0.1 0.2 0.8 -0.3 0.2 0.3 -0.7 0.0 0.0 0.9
Taking other prescription medications 0.1 0.1 0.6 -0.2 -0.1 0.0 -0.3 0.0 0.7 0.1
Age when periods started (menarche) 0.3 0.8 2.0 1.4 1.0 1.0 0.4 0.0 0.5 0.9
Bilateral oophorectomy (both ovaries removed) 2.0 2.4 4.2 -1.6 -2.0 -1.7 -0.1 0.0 1.8 -1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 2.7 -0.8 0.8 1.1 -1.6 0.0 -0.9 1.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.9 -0.2 0.8 1.0 -0.5 0.0 -0.3 0.7
Qualifications: CSEs or equivalent 0.4 0.6 3.4 -0.3 0.2 0.4 -1.9 0.0 -0.1 0.4
Serious illness, injury or assault to yourself 0.2 0.3 0.9 0.2 0.4 0.5 -0.3 0.0 -0.9 0.6
High blood pressure 0.6 1.7 6.1 -1.0 -1.4 -1.6 2.5 0.0 -0.3 -0.2
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.5 -0.4 -0.3 -0.2 0.2 0.0 1.2 0.5
Multivitamins +/- minerals 0.7 0.9 3.6 1.9 0.8 0.6 -0.1 0.0 -0.3 1.1
Stomach or abdominal pain in last month 1.5 1.8 3.1 0.3 1.5 1.5 -1.6 0.0 -1.8 1.7
Supplements: Glucosamine 0.6 0.8 2.3 0.3 0.7 0.9 -1.5 0.0 0.1 1.2
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 1.2 -0.2 0.5 0.6 -0.3 0.0 -1.1 0.4
Medication: Atenolol 0.3 0.4 1.4 1.2 0.4 0.0 0.8 0.0 -0.3 0.6
Medication: Levothyroxine sodium 0.1 0.1 0.3 -0.5 0.2 0.2 -0.4 0.0 0.1 0.4
Sitting height 0.1 0.6 1.3 0.5 1.0 0.9 -0.8 0.0 -1.2 0.3
Chronic bronchitis/emphysema (father) 0.4 0.5 0.9 0.4 0.8 1.0 -0.6 0.0 -0.8 0.9
High blood pressure (mother) 0.1 0.1 0.4 -0.7 -0.2 -0.3 0.4 0.0 0.1 0.3
Body mass index (BMI) 0.9 3.7 12.7 -3.6 -2.2 -2.2 -0.4 0.0 1.5 -1.1
Impedance of leg (left) 0.2 1.0 3.6 1.9 0.4 0.5 1.2 0.0 1.2 -0.4
Leg predicted mass (left) 0.1 0.6 2.9 -1.7 -0.2 -0.4 -0.8 0.0 -0.4 0.0
Trunk fat mass 0.2 1.0 4.7 -2.2 -0.9 -0.9 -0.1 0.0 0.8 -0.6
Waist circumference 0.1 0.4 1.9 -1.4 -0.0 -0.1 -0.8 0.0 0.2 0.6
Number of incorrect matches in round 0.4 0.7 2.6 -0.7 -0.9 -0.8 0.6 0.0 0.3 -1.6
Past tobacco smoking 0.9 1.6 5.5 2.3 1.2 1.5 -1.3 0.0 0.2 0.8
Alcohol usually taken with meals 0.7 1.2 2.4 0.8 1.6 1.3 -0.1 0.0 -1.3 1.3
Nervous feelings 2.2 4.0 6.8 0.9 2.4 2.6 -2.0 0.0 -2.2 2.5
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.1 0.0 0.8 1.0 -1.4 0.0 0.1 1.4
Hearing difficulty/problems with background noise 0.3 0.5 2.2 -0.9 -0.4 -0.5 -0.1 0.0 1.5 -0.0
Hair/balding pattern: Pattern 2 0.7 0.9 3.2 -0.9 0.2 0.3 -1.3 0.0 1.8 0.7
Had menopause 1.8 2.2 3.8 -1.1 -2.0 -1.9 1.5 0.0 0.9 -1.9
Had other major operations 0.5 0.6 1.6 -1.2 0.6 0.5 -0.1 0.0 -0.4 1.2
Forced vital capacity (FVC) 1.7 6.5 10.7 -3.0 -3.2 -3.0 2.2 0.0 1.5 -3.3
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.5 4.9 0.0 1.2 1.4 -1.0 0.0 -2.2 1.1
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.9 0.9 0.3 0.3 0.2 0.0 0.0 -0.2
Qualifications: None of the above 1.2 2.5 4.6 -1.8 -1.9 -1.8 0.9 0.0 1.5 -2.1
Financial difficulties in last 2 years 0.1 0.1 0.2 -0.2 -0.1 -0.3 -0.3 0.0 -0.4 -0.3
Mouth/teeth dental problems 0.4 0.6 1.7 -1.1 -0.7 -0.5 -0.5 0.0 1.3 0.3
Heart attack 0.1 0.1 0.4 0.1 0.0 -0.0 0.6 0.0 0.1 0.4
Allergy 0.2 0.4 1.2 0.3 -0.7 -0.8 0.6 0.0 0.1 -1.1
Pain all over the body in last month 0.3 0.4 1.4 0.1 -0.1 -0.2 0.5 0.0 -1.2 -0.9
Diabetes (self-reported) 0.2 0.2 1.1 0.2 0.1 -0.0 1.1 0.0 0.4 0.7
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 2.3 0.1 -0.1 -0.3 1.5 0.0 -0.5 0.2
Medication: Ramipril 0.6 0.8 2.2 -0.5 -0.8 -0.8 1.5 0.0 1.2 -0.5
Medication: Simvastatin 1.6 2.4 5.4 1.2 1.7 1.6 -1.1 0.0 -1.8 2.3
Fluid intelligence score 0.4 0.7 2.2 -0.3 0.9 0.8 -0.3 0.0 -1.5 1.2
Illnesses of siblings 0.5 0.7 2.2 -1.5 -1.1 -1.0 -0.5 0.0 0.6 -0.5
Neuroticism score 0.6 1.3 3.4 0.3 1.2 1.5 -1.8 0.0 0.1 1.3
Weight 0.4 1.7 7.5 -2.7 -1.3 -1.3 -0.3 0.0 0.7 -0.9
Impedance of arm (right) 2.1 9.6 16.8 3.8 4.1 4.1 -0.6 0.0 -2.4 3.6
Arm fat percentage (right) 0.2 1.0 4.8 -2.2 -0.7 -0.7 -0.6 0.0 0.7 0.0
Trunk fat-free mass 0.3 1.9 4.1 -2.0 -1.7 -1.8 0.0 0.0 0.8 -1.5
Hip circumference 0.1 0.6 2.6 -1.2 0.1 0.1 -1.6 0.0 0.1 0.6
Time employed in main current job 1.5 1.7 3.9 1.0 1.6 1.5 -0.0 0.0 -2.0 1.6
Alcohol intake versus 10 years previously 0.7 1.0 4.5 0.6 0.8 0.9 0.0 0.0 -2.1 0.8
Father’s age at death 1.4 1.9 2.9 0.7 1.6 1.7 -1.7 0.0 -1.4 1.6
Worrier / anxious feelings 0.8 1.5 3.3 1.8 1.4 1.6 -0.9 0.0 0.6 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 2.3 1.5 0.9 1.0 -0.4 0.0 1.0 1.1
Falls in the last year 0.1 0.1 0.3 -0.1 0.6 0.6 -0.3 0.0 -0.2 0.2
Hair/balding pattern: Pattern 3 0.6 0.9 2.2 1.0 0.9 1.2 -0.8 0.0 -1.5 0.3
Number of live births 0.3 0.4 1.5 -0.6 -0.3 -0.3 0.2 0.0 0.9 -1.2
Forced expiratory volume in 1-second (FEV1) 1.3 4.4 6.7 -2.6 -2.6 -2.4 1.7 0.0 1.6 -2.4
Pulse rate 1.6 2.6 5.4 2.3 2.0 2.1 -0.8 0.0 -0.9 1.8
Happiness 0.2 0.2 0.7 0.0 0.4 0.4 -0.4 0.0 0.8 0.8
Noisy workplace 0.8 1.0 1.8 -1.3 -0.7 -0.8 1.3 0.0 -1.2 -1.1
Qualifications: A levels/AS levels or equivalent 1.1 2.4 8.1 1.0 1.7 1.5 -0.9 0.0 -1.3 2.8
Serious illness, injury or assault of a close relative in last 2 years 2.6 3.0 6.8 0.4 2.3 2.1 -0.9 0.0 -1.8 2.6
Mouth/teeth dental problems: Dentures 0.3 0.6 1.8 0.3 -0.3 -0.5 1.3 0.0 -0.8 -1.1
Asthma 0.7 1.3 3.1 0.5 1.2 1.4 -1.8 0.0 -1.0 1.2
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 1.0 0.3 0.2 0.2 -1.0 0.0 1.0 0.2
Medication: Cholesterol lowering 0.2 0.3 0.9 0.4 0.2 0.0 0.9 0.0 0.4 0.8
Depression (self-reported) 0.2 0.3 1.1 0.8 -0.0 0.1 -0.0 0.0 1.1 0.1
Medication: Lansoprazole 0.9 1.1 5.9 -2.4 -0.7 -0.6 -0.3 0.0 -0.7 -0.1
Prospective memory result 3.3 4.1 7.0 -1.5 -2.3 -2.3 1.5 0.0 2.6 -2.5
Lung cancer (father) 0.0 0.0 0.1 -0.0 -0.1 0.1 -0.1 0.0 0.1 0.4
Illnesses of mother 0.3 0.4 0.8 -0.8 -0.6 -0.4 -0.9 0.0 0.4 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.5 4.9 7.5 -2.7 -2.7 -2.5 1.8 0.0 2.0 -2.4
Pulse wave Arterial Stiffness index 1.3 1.5 6.0 0.6 1.1 1.3 -2.4 0.0 -0.6 0.9
Impedance of arm (left) 1.3 6.0 10.6 3.1 3.2 3.3 0.1 0.0 -2.3 2.6
Arm fat mass (right) 0.4 1.5 5.9 -2.4 -1.3 -1.2 -0.6 0.0 1.0 -0.7
Trunk predicted mass 0.3 1.8 3.9 -2.0 -1.6 -1.8 0.0 0.0 0.8 -1.5
Standing height 0.1 1.2 2.5 1.4 1.6 1.5 0.1 0.0 -1.3 0.2
Length of working week for main job 0.2 0.3 0.9 -0.9 0.1 0.1 -0.0 0.0 -0.3 0.9
Exposure to tobacco smoke at home 1.3 1.4 3.3 -1.8 -1.4 -1.3 1.1 0.0 0.9 -1.0
Breastfed as a baby 0.5 0.6 2.5 -0.8 -0.3 -0.2 -0.7 0.0 1.6 0.5
Tense / ‘highly strung’ 0.4 0.7 1.6 0.6 1.1 1.3 -0.5 0.0 -1.1 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 3.2 4.9 8.1 2.6 2.7 2.8 -1.8 0.0 -1.4 2.5
Hair/balding pattern: Pattern 4 1.0 2.5 6.4 0.6 -1.5 -1.8 2.5 0.0 1.1 -2.0
Birth weight of first child 0.3 0.6 2.0 -1.4 -0.5 -0.4 0.8 0.0 0.8 -0.5
Peak expiratory flow (PEF) 0.2 0.4 1.1 -1.1 -0.8 -0.6 -0.3 0.0 0.2 -0.8
Pulse wave reflection index 1.2 1.5 5.0 -0.6 0.9 1.1 -2.2 0.0 -1.1 1.4
Ever highly irritable/argumentative for 2 days 0.7 0.8 3.3 -1.0 -0.8 -0.8 0.2 0.0 0.5 -1.8
Loud music exposure frequency 0.3 0.3 0.7 0.8 0.7 0.6 -0.8 0.0 -0.1 0.5
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 4.8 1.3 1.5 1.4 0.4 0.0 -2.2 2.0
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.6 0.0 0.0 0.0 0.4 0.0 -0.8 0.0
Blood clot in the leg (DVT) 1.7 2.2 5.7 -0.6 1.8 1.5 -0.8 0.0 -2.4 1.8
Medication: Paracetamol 0.1 0.2 1.0 0.2 -0.3 -0.1 -0.4 0.0 1.0 -0.3
Headache pain in last month 0.3 0.6 1.8 -0.5 -0.6 -0.5 -0.1 0.0 1.3 -1.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.4 0.5 0.3 0.5 -1.5 0.0 0.3 -0.4
Glaucoma (self-reported) 0.2 0.3 0.5 0.3 0.6 0.7 -0.6 0.0 -0.4 0.6
Gout (self-reported) 0.9 1.2 3.9 -0.7 -1.2 -1.5 2.0 0.0 0.3 -0.4
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.6 -0.1 0.3 0.3 -0.6 0.0 0.8 0.2
Medication: Amlodipine 0.9 1.2 4.4 -0.9 -1.2 -1.3 2.1 0.0 -0.2 -0.5
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.6 0.4 0.3 0.3 -0.8 0.0 0.0 0.4
Birth weight 0.2 0.4 2.2 -0.6 -0.1 -0.1 -0.1 0.0 -1.5 -0.5
Chronic bronchitis/emphysema (mother) 0.5 0.5 1.0 -0.9 -0.7 -0.7 1.0 0.0 0.9 0.4
High blood pressure (siblings) 0.8 1.1 3.4 1.8 1.3 1.2 -0.0 0.0 -0.9 0.7
Forced vital capacity (FVC), Best measure 1.6 5.8 9.1 -2.8 -3.0 -2.9 2.3 0.0 1.3 -2.9
Body fat percentage 0.4 1.5 5.7 -2.4 -1.2 -1.1 -0.1 0.0 1.2 -0.7
Leg fat percentage (right) 1.0 3.8 8.2 -2.9 -2.2 -2.1 0.1 0.0 2.5 -1.6
Arm fat-free mass (right) 0.7 3.7 7.1 -2.7 -2.4 -2.5 0.7 0.0 1.2 -2.3
Exposure to tobacco smoke outside home 0.3 0.3 0.9 0.5 0.4 0.4 0.9 0.0 0.5 0.9
Comparative body size at age 10 1.3 3.5 6.3 -2.3 -2.4 -2.3 1.2 0.0 0.7 -2.5
Number of full brothers 1.9 2.4 4.1 1.4 2.0 2.0 -1.8 0.0 -1.8 0.8
Worry too long after embarrassment 0.5 0.8 3.5 -1.0 -0.4 0.1 -1.9 0.0 1.1 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.9 1.4 1.0 1.0 -0.3 0.0 -1.1 0.3
Wheeze or whistling in the chest in last year 1.1 2.0 5.9 -0.3 1.3 1.6 -2.4 0.0 -1.6 1.0
Number of children fathered 0.6 0.7 1.4 -1.0 -1.1 -0.9 0.2 0.0 0.7 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.6 2.7 -1.2 -1.6 -1.6 1.6 0.0 0.1 -1.3
Age at first live birth 1.1 2.0 4.9 1.6 1.6 1.5 -0.6 0.0 -1.2 2.2
Pulse wave peak to peak time 1.0 1.2 5.2 -0.4 -1.0 -1.1 2.3 0.0 0.4 -0.9
Health satisfaction 0.8 1.0 2.3 1.3 1.1 1.1 -1.5 0.0 0.0 0.9
Shortness of breath walking on level ground 1.4 1.7 5.2 -0.1 1.4 1.4 -2.3 0.0 -0.6 1.5
Qualifications: College or University degree 1.5 4.7 12.3 1.4 2.6 2.3 -0.5 0.0 -2.6 3.5
Eye problems/disorders: None of the above 1.0 1.2 3.8 -0.6 0.8 1.0 -1.9 0.0 -0.6 1.4
Mouth/teeth dental problems: Loose teeth 0.6 0.7 4.2 0.3 0.6 0.5 0.4 0.0 -2.0 0.2
Emphysema/chronic bronchitis 0.6 0.7 2.8 -0.1 -0.8 -0.7 0.3 0.0 1.7 -0.9
Medication for pain relief, constipation, heartburn 0.4 0.7 2.4 0.5 0.9 0.8 0.3 0.0 -1.6 0.6
Neck or shoulder pain in last month 1.1 1.5 9.4 0.0 -0.6 -0.5 0.6 0.0 3.1 -0.5
Medication: Blood pressure 0.4 0.7 2.4 -0.9 -0.7 -0.9 1.6 0.0 -0.2 0.2
Angina (self-reported) 0.7 0.9 3.3 -0.2 -1.1 -1.1 0.6 0.0 1.8 -0.1
Migraine (self-reported) 0.6 0.7 1.7 -0.8 -0.7 -0.8 1.3 0.0 1.1 -0.7
Medication: Ibuprofen 0.4 0.4 1.6 -0.1 -0.4 -0.3 -1.0 0.0 1.2 -0.4
Medication: Allopurinol 4.6 6.1 11.5 -2.4 -3.1 -3.4 2.9 0.0 1.9 -1.9
Medication: Omeprazole 0.5 0.6 1.3 1.0 0.8 0.7 -0.5 0.0 -1.1 0.9
Medication: Seretide 50 evohaler 0.9 1.0 5.4 0.5 0.6 1.1 -2.3 0.0 -0.1 0.2
Mean time to correctly identify matches 1.2 2.2 3.9 -1.7 -2.0 -1.8 0.7 0.0 2.0 -1.1
Heart disease (mother) 0.3 0.4 1.7 0.1 0.9 0.7 0.1 0.0 -0.1 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 3.4 -0.3 1.0 1.2 -0.6 0.0 -0.7 1.9
Whole body fat mass 0.4 1.5 6.0 -2.5 -1.2 -1.2 -0.0 0.0 1.0 -0.9
Leg fat mass (right) 0.8 3.0 7.7 -2.8 -1.9 -1.9 0.0 0.0 1.9 -1.5
Arm predicted mass (right) 0.7 3.6 6.8 -2.6 -2.3 -2.4 0.5 0.0 1.2 -2.3
Pulse rate, automated reading 0.7 2.2 3.7 1.9 1.8 1.9 -1.2 0.0 0.2 1.8
Alcohol intake frequency. 0.3 0.7 2.2 -0.7 -1.0 -0.9 -0.0 0.0 -0.6 -1.5
Comparative height size at age 10 0.1 0.4 1.8 -0.6 -0.2 -0.1 0.2 0.0 -0.6 -1.4
Number of full sisters 2.1 2.6 9.0 -1.9 -1.4 -1.6 0.5 0.0 3.0 -0.9
Suffer from ‘nerves’ 3.9 6.1 10.4 3.0 3.1 3.2 -2.0 0.0 -1.4 2.8
Overall health rating 0.0 0.1 0.3 0.0 0.0 0.1 -0.6 0.0 0.0 0.0
Chest pain or discomfort 1.2 1.8 3.0 1.1 1.6 1.7 -1.3 0.0 -0.9 1.7
Had major operations 0.3 0.4 1.0 -0.6 -0.5 -0.6 0.8 0.0 -0.1 -1.0
Age at last live birth 1.7 2.4 5.8 1.7 1.9 1.8 -1.1 0.0 -0.5 2.4
Family relationship satisfaction 1.4 1.7 4.8 0.6 1.4 1.6 -2.2 0.0 -0.4 1.3
Leg pain on walking 0.4 0.5 1.9 -1.4 -0.5 -0.8 0.9 0.0 0.3 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 2.4 -0.7 0.3 0.4 -1.5 0.0 0.0 0.4
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.3 -1.0 0.1 -0.0 0.2 0.0 -1.2 0.3
Illness, injury, bereavement, stress in last 2 years 1.6 2.0 3.4 -1.3 -1.8 -1.7 0.8 0.0 1.6 -1.8
Medication: Aspirin 0.6 0.8 4.0 -0.1 -0.7 -0.6 0.7 0.0 2.0 -0.5
Supplements: Vitamin C 0.4 0.4 1.1 1.1 0.7 0.7 -0.8 0.0 -0.4 0.4
Knee pain experienced in last month 3.1 4.7 11.8 -3.4 -2.7 -2.5 -0.2 0.0 2.2 -1.7
Hypertension (Self-reported) 0.6 1.7 5.4 -0.9 -1.5 -1.7 2.3 0.0 0.0 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 4.0 -2.0 -0.6 -0.6 0.6 0.0 -1.0 0.1
Illnesses of father: Heart disease 1.0 1.3 5.7 0.6 -0.6 -0.9 2.4 0.0 0.5 -1.3
Illnesses of siblings: Diabetes 0.1 0.1 0.4 -0.6 0.1 -0.1 0.7 0.0 0.2 0.2
Smoking status: Previous 0.5 0.8 3.1 -1.7 -0.7 -1.0 1.0 0.0 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 3.6 0.4 1.7 1.5 -0.3 0.0 -1.9 1.0
Whole body fat-free mass 0.2 1.4 4.4 -2.1 -1.3 -1.5 -0.2 0.0 0.5 -1.2
Leg fat-free mass (right) 0.1 0.6 2.8 -1.7 -0.3 -0.4 -1.0 0.0 -0.6 -0.1
Arm fat percentage (left) 0.3 1.2 5.8 -2.4 -1.0 -1.0 -0.4 0.0 0.7 -0.4
Average weekly red wine intake 1.5 2.2 4.1 -0.3 2.0 1.7 -0.5 0.0 -2.0 2.0
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.6 0.2 0.5 0.5 -1.6 0.0 1.4 0.8
Mood swings 0.1 0.3 0.6 -0.0 0.6 0.7 -0.7 0.0 0.0 0.8
Loneliness, isolation 0.6 0.8 2.0 -0.3 0.7 1.0 -1.4 0.0 -0.4 1.4
Long-standing illness, disability or infirmity 0.1 0.1 0.3 -0.5 -0.3 -0.3 -0.2 0.0 -0.3 0.1
Ever had bowel cancer screening 0.2 0.2 0.5 -0.7 0.3 0.4 -0.3 0.0 -0.5 0.6
Diabetes diagnosed by doctor 0.4 0.7 1.1 0.6 1.0 0.9 0.5 0.0 -1.1 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.7 -0.4 0.6 0.4 -0.1 0.0 0.1 0.8
Friendships satisfaction 0.2 0.2 0.7 0.0 0.2 0.2 -0.5 0.0 0.9 0.6
Qualifications: nursing, teaching 0.2 0.2 0.8 0.3 0.0 -0.1 0.7 0.0 -0.9 0.6
Commuting to job workplace: Walk 1.5 1.6 3.2 1.5 1.6 1.7 -0.3 0.0 -0.6 1.8
Eye problems/disorders: Cataract 0.2 0.3 1.2 1.1 0.4 0.1 0.3 0.0 -0.6 0.2
Mouth/teeth dental problems: Mouth ulcers 2.5 4.0 7.4 2.1 2.7 2.5 -1.3 0.0 -2.2 1.8
Medication for cholesterol 0.6 0.8 2.2 0.7 1.4 1.1 0.3 0.0 -1.5 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.0 -1.0 -1.0 -1.0 0.3 0.0 0.7 -0.6
Back pain experienced in last month 0.7 1.1 3.9 -1.4 0.1 0.5 -2.0 0.0 1.0 0.6
Mineral and other dietary supplements 0.1 0.1 0.6 -0.2 0.1 0.1 -0.5 0.0 0.2 -0.8
Breast cancer (self-reported) 0.4 0.5 1.9 -1.4 -0.0 0.1 -0.4 0.0 0.1 1.1
Asthma (self-reported) 0.7 1.4 3.6 0.3 1.2 1.5 -1.9 0.0 -0.8 1.2
Osteoporosis (self-reported) 0.2 0.2 0.7 0.3 -0.7 -0.5 -0.1 0.0 -0.2 -0.8
Osteoarthritis (self-reported) 1.7 2.3 4.6 -1.0 -1.8 -1.7 0.6 0.0 2.0 -2.2
Medication: Aspirin 0.9 1.2 5.1 -0.3 -1.0 -0.9 0.9 0.0 2.3 -0.5
Medication: Gliclazide 0.8 0.9 2.6 1.2 1.0 1.0 0.6 0.0 -0.4 1.6
Illnesses of father: None of the above (group 1) 0.5 0.6 2.2 -0.1 -0.1 0.2 -1.5 0.0 1.2 0.8
Smoking status: Current 1.0 1.7 5.4 -0.8 -1.6 -1.4 0.5 0.0 0.7 -2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 3.3 -1.8 -1.8 -1.6 1.0 0.0 0.8 -0.8
Whole body water mass 0.3 1.5 4.3 -2.1 -1.4 -1.6 -0.2 0.0 0.5 -1.2
Leg predicted mass (right) 0.1 0.6 2.6 -1.6 -0.2 -0.4 -1.0 0.0 -0.5 -0.0
Arm fat mass (left) 0.4 1.7 6.0 -2.5 -1.4 -1.4 -0.4 0.0 1.0 -0.8
Number of self-reported non-cancer illnesses 0.3 0.5 2.5 0.3 0.6 0.6 -0.0 0.0 0.1 1.6
Average weekly champagne plus white wine intake 0.5 0.6 1.4 -0.3 -1.1 -1.1 0.7 0.0 1.2 -0.5
Miserableness 0.3 0.5 1.8 1.4 0.2 0.3 0.2 0.0 1.0 0.6
Guilty feelings 1.5 2.3 5.0 1.3 2.1 2.2 -1.4 0.0 -0.4 1.7
Wears glasses or contact lenses 0.4 0.4 1.4 1.2 -0.1 -0.0 0.5 0.0 1.0 -0.5
Ever taken oral contraceptive pill 0.9 1.0 1.9 1.0 1.1 1.2 -1.4 0.0 0.0 1.1
Hearing aid user 2.2 2.4 5.0 2.2 1.9 1.9 -1.7 0.0 -0.7 1.2
Mother’s age at death 0.2 0.3 1.1 0.1 0.5 0.6 -1.0 0.0 -0.5 0.2
Financial situation satisfaction 0.0 0.1 0.2 -0.3 -0.2 -0.1 -0.1 0.0 -0.2 -0.4
Tinnitus: Yes, now most or all of the time 0.5 0.5 1.6 1.1 0.5 0.1 0.3 0.0 1.3 0.8
Commuting to job workplace: Public transport 1.6 1.9 5.0 1.0 1.5 1.5 -1.6 0.0 0.5 2.2
Eye problems/disorders: Glaucoma 0.6 0.7 1.7 -1.3 -1.1 -1.1 0.3 0.0 0.2 -1.0
Medication: Blood pressure 1.3 2.4 5.0 -0.8 -2.2 -2.2 1.9 0.0 1.2 -1.2
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.9 -1.3 -0.2 -0.0 -1.4 0.0 -0.0 -0.3
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.3 -0.6 -0.6 -0.6 0.4 0.0 0.2 0.6
High cholesterol (Self-reported) 0.1 0.2 0.8 -0.3 0.2 0.2 -0.1 0.0 0.3 0.9
Medication: Bendroflumethiazide 0.8 1.2 2.5 -0.7 -1.6 -1.6 1.3 0.0 0.1 -1.2
Medication: Paracetamol 0.2 0.2 1.3 0.3 -0.3 -0.1 -0.5 0.0 1.1 -0.2
Medication: Lisinopril 0.3 0.4 0.8 -0.8 -0.6 -0.4 0.8 0.0 0.9 0.2
Medication: Atorvastatin 0.1 0.1 0.4 0.1 -0.2 -0.1 0.6 0.0 0.4 0.3
Illnesses of father: High blood pressure 0.2 0.2 0.5 -0.5 -0.4 -0.6 0.7 0.0 -0.2 0.3
Alcohol drinker status: Never 0.7 0.8 2.6 -0.7 -0.9 -0.9 0.1 0.0 -1.0 -1.6
Ever smoked 1.3 2.3 6.5 -2.5 -1.7 -1.8 1.0 0.0 0.2 -1.6
Basal metabolic rate 0.3 1.4 4.8 -2.2 -1.3 -1.4 -0.3 0.0 0.6 -1.0
Leg fat percentage (left) 0.9 3.1 7.2 -2.7 -2.0 -1.9 -0.3 0.0 2.1 -1.6
Arm fat-free mass (left) 0.5 2.5 5.1 -2.2 -1.9 -2.0 -0.0 0.0 1.3 -1.8
Number of operations (self-reported) 0.3 0.5 2.5 -1.0 -0.1 -0.2 1.6 0.0 0.1 0.1
Average weekly beer plus cider intake 0.6 0.8 1.8 1.3 0.7 0.7 0.1 0.0 -1.4 1.0
Irritability 0.1 0.1 0.3 -0.5 0.2 0.2 -0.4 0.0 -0.5 0.2
Risk taking 0.3 0.5 2.1 0.1 0.7 0.7 0.5 0.0 -1.5 0.4
Ever had prostate specific antigen (PSA) test 2.0 2.3 5.3 -1.5 -1.8 -1.7 1.2 0.0 2.3 -0.9
Fractured/broken bones in last 5 years 2.0 2.6 5.3 2.3 1.7 1.7 -1.0 0.0 -2.2 1.0
Age started oral contraceptive pill 0.2 0.3 0.8 -0.4 -0.5 -0.5 0.9 0.0 0.3 -0.6
Diastolic blood pressure, automated reading 0.1 0.4 1.4 -1.2 -0.6 -0.7 -0.3 0.0 0.5 -0.1
Ever depressed for a whole week 0.9 1.1 2.3 0.7 1.5 1.5 -0.5 0.0 -1.0 1.3
Unable to work because of sickness or disability 0.1 0.2 0.7 -0.6 0.0 -0.1 0.8 0.0 -0.2 -0.1
Commuting to job workplace: Cycle 0.3 0.3 1.2 0.1 0.2 0.3 -1.1 0.0 -0.4 0.9
Myopia 0.6 0.8 1.9 -1.4 -0.8 -0.9 1.4 0.0 -0.6 -0.2
Vascular/heart problems diagnosed by doctor 0.7 1.9 6.1 1.1 1.5 1.8 -2.5 0.0 -0.2 0.3
Cholesterol lowering medication 0.6 0.8 2.5 -0.1 0.7 1.0 -1.3 0.0 -0.2 1.6
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.2 0.4 1.2 1.2 -1.3 0.0 -1.1 1.5
Pain experienced in last month 1.1 1.8 5.5 1.5 1.1 0.9 1.1 0.0 -2.3 1.2
Supplements: Calcium 0.4 0.4 1.4 0.5 -0.7 -0.7 1.2 0.0 -0.3 -0.4
Basal cell carcinoma (self-reported) 0.5 0.6 3.0 0.9 -0.0 -0.1 -0.1 0.0 1.7 -0.2
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.7 0.4 0.5 0.5 0.4 0.0 -0.3 0.8
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 5.3 -0.8 1.5 1.3 -0.6 0.0 -2.3 1.6
Heart disease (siblings) 0.6 0.7 0.9 1.0 0.8 1.0 -0.9 0.0 0.7 0.9
Alcohol drinker status: Previous 1.2 1.4 4.8 -0.7 1.1 1.0 0.0 0.0 -2.2 1.5
Pack years of smoking 0.5 0.7 2.8 -0.4 -0.9 -0.5 -0.9 0.0 -0.2 -1.7
Impedance of whole body 0.8 3.9 10.1 3.2 2.5 2.5 0.7 0.0 -1.2 1.6
Leg fat mass (left) 0.7 2.7 7.5 -2.7 -1.8 -1.7 -0.3 0.0 1.6 -1.5
Arm predicted mass (left) 0.5 2.8 5.7 -2.4 -2.1 -2.1 0.1 0.0 1.3 -1.8