Hub : Genes

RP11-333E1.1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.197	0.082	0.0081	0.154	NA	0.091	NA	0.122	0.00001	NA	0.00070	NA	8.8e-05
2	GTEx	Colon Sigmoid	0.298	0.101	0.0013	-0.008	NA	0.065	NA	0.005	0.80000	NA	0.00260	NA	2.0e-01
3	GTEx	Spleen	0.350	0.123	0.0046	0.064	NA	0.032	NA	-0.011	0.01000	NA	0.05300	NA	7.8e-01
4	GTEx	Thyroid	0.115	0.042	0.0013	0.049	NA	0.042	NA	0.043	0.00012	NA	0.00036	NA	3.1e-04
5	GTEx	Whole Blood	0.071	0.032	0.0087	0.033	NA	0.019	NA	0.022	0.00046	NA	0.00610	NA	4.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.4	2.2	5.0	-2.2	-1.7	-0.6	0.1	-1.7
Bipolar Disorder or Schizophrenia	0.7	1.7	3.8	-1.9	-1.3	-1.0	-0.4	-1.5
Depressed Affect (Nagel 2018)	1.0	2.1	3.4	-1.7	-1.6	-1.8	-0.2	-1.2
Depression (Nagel 2018)	0.8	1.2	2.9	-1.7	-0.3	-1.0	0.8	-1.1
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.5	-0.4	-1.2	-0.2	-0.9	-0.0
Neuroticism (Nagel 2018)	0.8	1.8	3.3	-1.8	-1.3	-1.2	-0.8	-1.5
Schizophrenia (2018)	0.2	0.3	0.6	-0.7	-0.3	-0.8	-0.5	-0.5
Schizophrenia vs Biploar Disorder	0.4	0.6	1.3	1.1	0.1	0.2	-0.7	1.1
Worry (Nagel 2018)	0.1	0.1	0.3	-0.1	0.5	0.3	0.2	-0.5
Alzheimer’s Disease (in mother)	0.8	1.0	2.0	0.1	-0.6	-0.9	1.4	1.3
Alzheimer’s Disease (in father)	1.7	1.9	3.9	-1.2	-2.0	-0.2	1.6	1.2
Alzheimer’s Disease (including proxy)	3.3	4.8	14.0	-1.2	-2.1	-0.1	3.7	2.0
Crohns Disease (2017)	0.4	0.8	2.8	-0.4	0.4	0.7	1.7	0.6
Irritable Bowel Disease (IBD)	0.7	1.6	2.9	-1.7	-1.6	-0.8	1.0	-0.9
Ulcerative Colitis (UC)	1.5	2.8	4.5	-2.1	-1.9	-1.7	0.4	-1.7
Major Depression (MDD)	1.2	1.4	2.8	-1.2	1.0	-0.7	1.7	-1.2
Reaction Time	0.5	0.9	2.6	0.1	-0.6	-0.1	1.6	1.3
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.4	1.6	1.0	1.6	-0.2	1.4
Breast Cancer	0.5	1.2	2.8	0.9	1.7	0.2	-1.4	-0.7
Ovarian Cancer	0.5	0.6	1.6	0.7	1.3	0.8	0.4	0.4
Prostate Cancer	0.9	1.2	2.2	0.8	0.9	1.5	1.2	1.0
Age at First Birth	0.3	0.5	2.2	-0.4	-0.1	1.5	0.3	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	0.3	0.3	-0.4	1.0	0.8
Coronary Artery Disease (CAD)	1.3	1.5	6.5	0.5	0.5	-0.3	-2.5	-0.7
Crohns Disease (2012)	0.8	1.3	4.6	-2.1	-0.1	-0.4	-0.2	-1.3
Mean Putamen Volume	0.3	0.3	0.8	-0.9	-0.6	-0.0	0.5	-0.5
Fasting Glucose	0.6	0.7	2.0	-0.2	-0.7	-0.1	1.4	1.0
HbA1C	0.8	0.9	2.9	-0.4	-1.2	-0.4	-1.7	0.1
HDL Cholesterol	0.6	1.0	3.6	-0.4	-1.1	-0.2	1.9	-0.0
LDL Cholesterol	0.6	1.0	2.6	0.5	-1.1	-0.9	-1.6	0.2
Lupus	1.8	2.7	8.6	2.9	0.4	1.3	-0.3	1.7
Neuroticism (2016)	0.5	0.7	1.3	-1.0	0.9	-0.7	-0.1	-1.2
Primary Biliary Cirrhosis	1.3	1.8	3.6	-0.5	-0.9	-1.7	-1.9	-1.2
Rheumatoid Arthritis	3.2	4.4	11.2	3.3	0.1	2.5	0.3	2.2
Schizophrenia (2014)	0.9	2.0	4.5	-0.9	-1.1	-1.5	-2.1	-1.1
Triglycerides	0.4	0.6	1.2	0.5	-1.1	-0.6	-1.1	-0.1
Type 2 Diabetes (T2D) (2012)	1.1	1.2	2.8	1.7	0.3	1.3	0.3	1.3
Ulcerative Colitis	2.6	3.7	9.9	-2.0	-3.1	-1.6	0.0	-1.5
Blood Eosinophil Count	0.7	5.8	10.7	2.4	-0.4	2.3	3.3	2.6
Blood Platelet Count	0.9	10.4	37.7	-2.8	-2.5	-0.5	6.1	0.1
Blood Red Count	0.2	2.3	6.4	1.0	0.2	1.2	1.6	2.5
Blood White Count	2.7	19.9	58.8	1.8	-1.9	2.6	7.7	5.2
Heel T-Score	1.4	11.5	16.8	3.3	-2.6	3.9	2.9	4.1
BMI	1.1	6.2	17.6	-0.3	-4.2	-0.7	3.2	1.6
Height	0.0	0.5	1.0	-1.0	-0.0	-0.5	-0.1	-1.0
Waist Hip Ratio (WHR)	0.0	0.1	0.3	-0.4	-0.4	-0.6	-0.2	0.1
Systolic Blood Pressure	0.3	1.3	2.6	1.3	-0.1	1.2	-1.6	0.9
Smoking Status	0.5	1.2	3.7	-0.8	-1.2	-0.1	1.9	0.3
Allergy or Eczema	0.6	1.6	2.7	1.2	-1.6	1.1	0.2	1.6
Cardiovascular Disease	0.2	0.6	1.8	0.7	-0.6	0.4	-1.3	0.2
Hypothyroidism (self reported)	0.9	2.2	4.8	2.2	1.7	1.5	-0.6	0.8
Respiratory disease	0.3	0.6	2.3	0.1	-1.5	-0.4	0.5	-0.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.0	-0.5	-1.4	-0.2	1.1	-0.0
Lung FEV1/FVC ratio	0.2	0.8	2.6	-0.5	-1.6	0.0	1.0	0.3
Lung FVC	0.2	1.0	2.8	0.9	0.3	1.7	0.9	0.8
Neuroticism	0.7	1.7	3.2	-1.8	-1.4	-1.1	-0.6	-1.2
Chronotype (morning person)	0.7	1.6	2.8	-0.9	-0.8	-1.3	-1.4	-1.7
Hair Pigment	0.1	2.3	4.6	-1.6	0.5	-1.7	-1.1	-2.1
Tanning	0.2	2.3	4.5	1.4	1.0	2.1	1.4	1.4
Hand grip strength (left)	1.4	3.6	8.4	0.7	0.6	2.9	2.2	2.0
Number of treatments/medications taken	0.2	0.3	0.9	-0.4	-0.2	-0.8	-0.1	-0.9
Average weekly spirits intake	1.1	1.4	6.6	-0.6	-2.6	-0.1	0.2	-0.2
Sensitivity / hurt feelings	0.6	1.0	2.4	-0.7	-1.5	-0.4	-1.0	-0.8
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.6	-1.2	-1.3	-0.3	0.7	-1.1
Hearing difficulty/problems: Yes	2.0	3.1	6.0	-1.2	-2.4	-1.8	-1.3	-1.7
Relative age of first facial hair	0.7	1.5	3.6	1.9	0.8	0.8	-1.3	0.9
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	5.9	0.2	-2.4	0.6	0.9	0.4
Ever used hormone-replacement therapy (HRT)	6.4	8.2	10.0	-3.0	-2.2	-2.8	-3.0	-3.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.9	-0.9	0.7	-0.4	0.0	-1.4
Systolic blood pressure, automated reading	0.4	1.1	2.9	1.2	-1.7	0.5	-1.0	0.5
Eye problems/disorders: Diabetes related eye disease	1.0	1.0	2.0	-1.2	-1.4	-0.1	1.0	-1.0
Angina	0.9	1.1	2.2	-1.3	-0.9	-0.7	-0.7	-1.5
Medication for hormone replacement therapy	0.5	0.5	1.9	-0.7	-0.3	-0.3	0.3	-1.4
Vitamin and mineral supplements	0.1	0.1	0.2	0.2	-0.5	-0.1	0.4	0.3
Supplements: Zinc	1.7	1.8	3.0	-1.7	-1.0	-1.7	0.4	-1.4
Medication: Co-codamol	1.2	1.4	3.3	-1.1	-1.8	-1.5	0.3	-0.5
Medication: Metformin	0.8	1.2	3.2	-0.3	-1.8	-0.1	1.6	-0.3
Diabetes (father)	0.4	0.4	0.8	0.9	-0.7	0.3	0.6	0.7
Diabetes (mother)	0.1	0.2	0.4	-0.6	0.6	-0.4	-0.3	-0.2
Severe depression (siblings)	0.6	0.7	1.6	-0.8	-1.3	-0.9	0.6	-0.4
Pack years adult smoking proportion	0.4	0.6	1.3	-0.6	-0.1	-0.9	-1.1	-0.8
Impedance of leg (right)	0.5	2.2	7.4	0.6	2.7	0.5	-1.7	0.5
Leg fat-free mass (left)	0.8	4.5	11.0	0.0	-3.3	-0.0	3.1	1.3
Trunk fat percentage	0.6	2.3	5.3	-0.1	-2.3	-0.7	2.1	1.1
Hand grip strength (right)	1.2	3.2	5.8	0.7	0.3	2.4	2.2	2.2
Townsend deprivation index at recruitment	1.4	2.0	4.3	-2.1	1.3	-1.2	0.6	-1.6
Current tobacco smoking	0.2	0.3	1.5	-0.2	0.1	-0.2	1.2	0.4
Average weekly fortified wine intake	0.2	0.2	0.6	-0.0	0.8	0.1	0.1	0.6
Maternal smoking around birth	0.6	0.9	1.8	-1.0	1.1	-1.3	0.5	-0.6
Fed-up feelings	2.4	4.4	8.6	-2.9	-2.6	-1.9	0.3	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	3.0	7.9	-2.8	-1.0	-1.5	0.8	-1.8
Relative age voice broke	0.1	0.2	0.4	0.6	-0.2	0.5	-0.2	0.5
Taking other prescription medications	0.4	0.6	1.5	1.1	0.2	-0.6	-1.2	-0.3
Age when periods started (menarche)	1.6	3.8	6.9	-1.2	-1.4	-1.9	-2.6	-2.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-1.0	-0.7	0.1	0.8	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	5.1	0.6	-2.2	0.3	1.8	0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.9	-0.5	0.2	-0.7	0.9	0.2
Qualifications: CSEs or equivalent	0.7	0.9	2.1	0.0	-1.4	-0.9	1.1	0.5
Serious illness, injury or assault to yourself	0.5	0.6	1.5	-0.7	-0.7	-1.2	0.6	-0.4
High blood pressure	0.3	0.8	2.6	1.1	0.5	0.1	-1.6	0.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.8	-0.2	-1.7	-0.0	0.3	0.3
Multivitamins +/- minerals	0.3	0.4	0.7	0.6	0.9	0.7	-0.3	0.5
Stomach or abdominal pain in last month	1.2	1.5	2.4	-1.3	-1.5	-1.4	-0.8	-0.9
Supplements: Glucosamine	0.6	0.8	1.1	-0.9	-1.0	-0.8	-1.0	-0.7
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.1	-0.5	0.6	0.3	-0.0
Medication: Atenolol	1.4	1.8	2.9	-1.2	1.1	-1.5	-1.7	-1.1
Medication: Levothyroxine sodium	0.6	0.9	2.3	1.3	0.6	1.5	-0.4	0.4
Sitting height	0.1	0.9	3.2	0.4	-1.8	-0.3	0.8	0.7
Chronic bronchitis/emphysema (father)	0.8	0.9	2.0	1.1	-0.6	0.2	1.4	0.9
High blood pressure (mother)	0.8	1.1	4.3	0.5	-0.8	-0.6	-2.1	0.5
Body mass index (BMI)	1.0	4.5	13.1	0.1	-3.6	-0.4	2.7	1.3
Impedance of leg (left)	0.4	2.0	8.4	0.6	2.9	0.4	-1.0	0.4
Leg predicted mass (left)	0.9	4.6	10.9	0.1	-3.3	0.1	3.2	1.4
Trunk fat mass	0.8	3.4	8.4	-0.0	-2.9	-0.6	2.6	1.3
Waist circumference	1.0	3.6	10.7	0.3	-3.3	-0.5	2.3	1.3
Number of incorrect matches in round	0.3	0.5	1.7	0.1	0.4	0.7	-1.3	-0.1
Past tobacco smoking	0.7	1.4	6.0	0.3	2.4	-0.4	-0.7	-0.1
Alcohol usually taken with meals	2.2	3.6	7.5	2.7	1.3	1.7	-0.7	2.3
Nervous feelings	0.5	1.0	2.0	-0.4	1.0	-0.5	-1.3	-1.4
Frequency of tenseness / restlessness in last 2 weeks	3.3	5.2	9.9	-3.1	-0.9	-2.5	-0.6	-3.0
Hearing difficulty/problems with background noise	0.5	0.8	2.4	-0.4	-1.6	-1.0	-0.3	-0.4
Hair/balding pattern: Pattern 2	0.4	0.6	1.0	0.3	1.0	0.8	0.5	0.9
Had menopause	2.1	2.6	6.0	-1.3	0.0	-0.6	-2.4	-2.2
Had other major operations	0.2	0.3	0.7	-0.5	0.3	-0.1	0.9	-0.6
Forced vital capacity (FVC)	0.7	2.7	4.8	1.4	-0.5	1.8	1.7	2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	4.7	0.5	-2.2	0.0	1.1	0.8
Ever unenthusiastic/disinterested for a whole week	1.4	1.8	5.1	-2.3	0.0	-1.1	0.1	-1.6
Qualifications: None of the above	1.9	4.0	7.1	-1.7	1.5	-2.4	-1.6	-2.7
Financial difficulties in last 2 years	2.3	3.1	11.9	-0.1	-1.5	1.0	3.4	0.7
Mouth/teeth dental problems	1.8	2.7	5.7	2.4	-0.3	1.8	0.5	2.1
Heart attack	0.5	0.7	1.4	-0.7	0.4	-1.2	-0.8	-0.8
Allergy	0.4	1.0	4.0	0.2	2.0	-0.4	-1.0	-0.0
Pain all over the body in last month	1.3	1.4	3.3	-1.8	-0.3	-1.3	0.9	-1.0
Diabetes (self-reported)	1.0	1.5	4.6	-0.3	-2.1	0.1	1.7	0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.1	0.4	0.5	0.5	-0.1
Medication: Ramipril	1.6	2.0	3.6	-1.6	-0.6	-1.9	-0.4	-1.9
Medication: Simvastatin	1.8	2.6	4.7	-1.1	-1.7	-1.3	-2.2	-1.6
Fluid intelligence score	0.8	1.7	3.2	0.8	0.0	1.5	1.8	1.6
Illnesses of siblings	1.5	2.1	5.3	0.7	0.4	1.6	1.5	2.3
Neuroticism score	0.7	1.5	3.9	-2.0	-1.3	-0.7	0.5	-1.1
Weight	0.9	4.6	11.6	0.2	-3.4	-0.3	3.0	1.4
Impedance of arm (right)	0.6	3.0	12.5	-0.0	3.5	-0.2	-1.4	-0.7
Arm fat percentage (right)	0.8	3.2	7.3	-0.1	-2.7	-0.4	2.7	1.3
Trunk fat-free mass	0.6	3.7	8.4	0.4	-2.6	0.6	2.9	1.6
Hip circumference	1.1	4.9	11.4	1.0	-3.4	0.0	2.8	2.0
Time employed in main current job	0.5	0.5	2.0	-0.2	-1.4	0.4	-0.6	0.1
Alcohol intake versus 10 years previously	0.9	1.4	6.8	-0.1	-0.3	0.1	2.6	-0.4
Father’s age at death	0.0	0.1	0.2	0.3	0.2	-0.1	0.4	0.2
Worrier / anxious feelings	0.6	1.2	3.1	0.8	-0.3	1.8	1.5	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	2.0	-1.1	-1.2	-1.4	-0.3	-1.2
Falls in the last year	1.6	2.2	5.5	-0.4	-1.3	-2.3	-1.7	-1.0
Hair/balding pattern: Pattern 3	0.9	1.4	2.7	1.6	0.2	1.1	0.6	1.6
Number of live births	1.4	2.0	4.1	-1.3	0.4	-2.0	-1.4	-1.5
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	9.0	2.1	-0.5	2.1	1.9	3.0
Pulse rate	0.9	1.4	2.5	-1.4	-1.1	-0.6	1.1	-1.6
Happiness	1.4	1.7	4.8	-1.5	-0.4	-0.8	-0.9	-2.2
Noisy workplace	0.2	0.3	0.6	-0.4	0.3	-0.8	-0.2	-0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.9	1.0	-0.7	0.4	-0.1	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.5	1.0	-0.1	0.8	-0.2	1.9
Mouth/teeth dental problems: Dentures	2.0	3.5	5.4	-2.1	-0.5	-2.3	-1.9	-1.9
Asthma	0.6	1.1	2.3	1.5	-1.4	0.8	0.6	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.5	0.7	-0.5	0.4	1.9	1.6
Medication: Cholesterol lowering	0.4	0.7	1.8	-0.3	0.0	-0.9	-1.3	-0.8
Depression (self-reported)	0.7	0.9	3.3	-0.9	0.1	0.6	1.8	-0.1
Medication: Lansoprazole	0.4	0.5	1.3	1.1	-0.5	0.7	-0.1	0.6
Prospective memory result	3.3	4.1	5.3	-1.0	-2.1	-2.2	-2.3	-2.2
Lung cancer (father)	2.5	2.9	6.1	2.5	-0.4	1.5	0.7	2.4
Illnesses of mother	0.9	1.1	4.5	-0.7	0.5	0.5	2.1	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	6.9	2.2	-0.4	2.4	1.8	2.6
Pulse wave Arterial Stiffness index	0.2	0.3	1.0	-0.2	0.6	-0.1	1.0	-0.1
Impedance of arm (left)	0.6	2.6	7.9	0.0	2.8	-0.5	-2.1	-0.7
Arm fat mass (right)	1.3	5.2	13.1	-0.4	-3.6	-0.7	3.3	1.0
Trunk predicted mass	0.6	3.6	8.0	0.3	-2.7	0.5	2.8	1.5
Standing height	0.0	0.3	1.3	0.1	-0.0	0.3	1.2	0.5
Length of working week for main job	0.9	1.0	2.8	0.4	-1.3	0.1	1.7	0.6
Exposure to tobacco smoke at home	0.7	0.8	1.3	-1.1	-0.8	-1.1	0.2	-1.0
Breastfed as a baby	0.3	0.4	1.0	-0.4	-0.7	-1.0	-0.5	-0.4
Tense / ‘highly strung’	1.8	3.0	5.1	-2.0	-1.7	-1.5	-0.6	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	4.8	-2.2	-0.9	-1.5	1.7	-1.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.2	-0.3	0.6	-0.8	-0.7
Birth weight of first child	0.4	0.8	1.1	-1.0	-0.7	-0.6	1.1	-0.9
Peak expiratory flow (PEF)	2.5	5.8	11.1	2.6	-0.0	1.9	2.7	3.3
Pulse wave reflection index	1.1	1.3	2.3	1.5	0.5	1.5	0.1	1.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.4	-1.5	-1.5	-0.2	0.6	-0.7
Loud music exposure frequency	0.7	0.8	3.3	0.3	-0.3	-0.5	-1.8	-0.5
Qualifications: O levels/GCSEs or equivalent	2.9	4.6	8.3	1.8	0.2	2.5	2.3	2.9
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.6	-1.3	-0.4	-1.4	-0.4	-1.6
Blood clot in the leg (DVT)	0.9	1.2	2.7	0.4	-1.6	1.2	0.9	0.8
Medication: Paracetamol	1.6	2.7	4.8	-1.8	-2.2	-0.6	2.1	-0.7
Headache pain in last month	0.3	0.6	1.9	-0.3	-1.4	-0.9	0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	3.0	0.3	-0.5	1.1	1.7	0.9
Glaucoma (self-reported)	0.2	0.2	0.5	0.4	0.2	0.7	-0.4	0.6
Gout (self-reported)	0.0	0.1	0.2	-0.3	0.2	0.0	0.1	-0.4
Hypothyroidism/myxoedema (self-reported)	1.8	3.6	6.9	2.6	1.9	2.2	-0.7	1.3
Medication: Amlodipine	2.9	4.1	7.9	-1.7	-2.8	-1.9	-0.5	-2.4
Medication: Ventolin 100micrograms inhaler	2.0	2.6	4.7	-1.6	-1.2	-1.9	0.6	-2.2
Birth weight	0.1	0.3	0.7	-0.8	0.5	-0.4	0.3	0.3
Chronic bronchitis/emphysema (mother)	1.6	1.9	3.9	-2.0	-0.3	-1.1	0.5	-2.0
High blood pressure (siblings)	0.6	0.9	3.1	-0.2	0.5	-0.5	-0.9	-1.8
Forced vital capacity (FVC), Best measure	1.2	4.3	6.1	2.2	-0.5	2.5	2.0	2.5
Body fat percentage	0.6	2.4	6.0	0.0	-2.5	-0.4	2.0	1.3
Leg fat percentage (right)	0.8	3.1	6.8	0.6	-2.6	0.3	2.0	2.0
Arm fat-free mass (right)	0.8	4.1	9.9	0.6	-3.1	0.3	2.6	1.8
Exposure to tobacco smoke outside home	1.3	1.7	5.0	-1.0	-2.2	-1.1	1.0	-0.5
Comparative body size at age 10	0.5	1.5	3.1	1.7	1.2	1.0	0.0	1.4
Number of full brothers	1.6	2.1	4.2	-2.0	-0.3	-1.8	0.5	-1.6
Worry too long after embarrassment	1.1	1.9	4.2	-2.1	0.3	-1.0	-0.8	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.9	3.2	-1.7	-1.0	-1.1	1.8	-1.1
Wheeze or whistling in the chest in last year	1.4	2.5	4.8	-0.8	-2.2	-2.2	-0.8	-1.4
Number of children fathered	1.7	1.9	3.1	0.8	-0.8	1.5	1.7	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.3	-0.9	-0.2	-0.3	-0.2	-1.1
Age at first live birth	0.9	1.6	3.1	1.8	-0.6	1.8	0.1	1.2
Pulse wave peak to peak time	0.2	0.2	0.7	0.4	-0.4	0.3	-0.9	0.2
Health satisfaction	6.6	8.5	12.0	-2.9	-2.0	-3.5	-2.6	-3.4
Shortness of breath walking on level ground	0.7	0.9	1.5	-1.1	-0.9	-0.9	0.2	-1.2
Qualifications: College or University degree	0.9	2.7	4.1	1.9	1.1	2.0	-1.2	1.8
Eye problems/disorders: None of the above	1.2	1.3	2.7	1.2	1.6	0.2	0.9	1.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.3	-0.2	0.4	0.2	1.1	-0.4
Emphysema/chronic bronchitis	1.7	1.9	4.4	-2.1	0.1	-1.1	1.4	-1.4
Medication for pain relief, constipation, heartburn	1.3	2.3	6.1	1.4	2.5	1.6	0.2	1.0
Neck or shoulder pain in last month	0.7	1.0	1.5	-0.5	-1.2	-1.1	-1.1	-1.0
Medication: Blood pressure	0.6	1.1	1.7	-0.6	0.3	-1.3	-1.3	-1.3
Angina (self-reported)	0.7	0.9	2.0	-1.3	-0.7	-0.4	-0.6	-1.4
Migraine (self-reported)	2.0	2.5	3.6	1.4	1.9	1.9	0.0	1.8
Medication: Ibuprofen	1.2	1.5	3.1	1.0	-0.2	0.9	1.8	1.5
Medication: Allopurinol	0.4	0.5	1.5	-0.3	-0.2	-0.6	-1.2	-0.8
Medication: Omeprazole	0.8	0.9	1.5	-1.2	-0.8	-0.6	-0.7	-1.2
Medication: Seretide 50 evohaler	0.3	0.3	0.7	-0.1	0.8	0.4	0.7	-0.6
Mean time to correctly identify matches	0.1	0.1	0.4	-0.4	-0.2	-0.6	-0.1	0.1
Heart disease (mother)	0.9	1.1	4.4	0.8	-0.8	-0.2	-2.1	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	4.6	2.1	0.9	1.1	-0.4	1.6
Whole body fat mass	0.9	3.6	9.9	-0.1	-3.1	-0.6	2.5	1.2
Leg fat mass (right)	1.3	5.0	11.9	0.4	-3.5	0.1	3.0	1.9
Arm predicted mass (right)	0.8	4.3	9.0	0.7	-2.9	0.3	3.0	1.9
Pulse rate, automated reading	0.4	1.3	3.6	-1.3	-0.5	-0.8	0.3	-1.9
Alcohol intake frequency.	0.4	0.9	2.2	-0.5	0.9	-0.8	1.5	-0.7
Comparative height size at age 10	0.1	0.4	1.0	-0.5	0.8	-1.0	0.4	0.3
Number of full sisters	0.7	0.9	2.5	-1.0	-0.2	-0.6	-0.7	-1.6
Suffer from ‘nerves’	0.6	0.9	2.6	-1.6	0.2	-0.8	0.5	-1.0
Overall health rating	3.4	7.2	15.2	-1.8	-2.5	-3.9	-2.1	-2.7
Chest pain or discomfort	0.2	0.3	0.8	-0.4	-0.3	0.8	0.9	0.1
Had major operations	1.0	1.2	3.1	-0.4	-1.0	-1.0	-1.8	-0.7
Age at last live birth	0.3	0.4	1.1	0.5	-1.1	0.2	-0.5	0.4
Family relationship satisfaction	1.1	1.4	3.1	-1.2	-1.2	-0.5	-0.7	-1.8
Leg pain on walking	1.2	1.5	2.5	-1.1	-0.5	-1.6	-1.2	-1.5
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.2	5.2	1.6	-1.8	0.2	2.2	2.3
Commuting to job workplace: Car/motor vehicle	2.1	2.5	5.0	1.8	-0.5	1.4	1.4	2.2
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.2	0.4	1.4	-0.4	-1.5	-1.0
Medication: Aspirin	1.6	2.1	4.2	-0.8	-1.3	-1.4	-2.0	-1.5
Supplements: Vitamin C	0.1	0.1	0.4	-0.3	0.1	-0.1	0.5	-0.6
Knee pain experienced in last month	0.5	0.8	2.8	-0.5	-1.7	-0.2	-0.0	-1.0
Hypertension (Self-reported)	0.3	0.7	1.6	1.3	-0.3	0.4	-1.3	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.1	-0.7	-1.0	-0.8	-2.0	-0.8
Illnesses of father: Heart disease	1.6	2.2	3.6	-1.2	-0.4	-1.9	-1.6	-1.7
Illnesses of siblings: Diabetes	0.9	1.2	2.1	-0.4	-0.6	-1.3	-1.5	-1.2
Smoking status: Previous	1.0	1.5	6.1	-0.5	-2.5	0.4	1.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.8	0.0	0.0	0.2	1.7	0.6
Whole body fat-free mass	0.8	4.5	10.3	0.3	-3.0	0.4	3.2	1.6
Leg fat-free mass (right)	0.9	4.7	12.5	0.2	-3.0	0.2	3.5	1.4
Arm fat percentage (left)	0.8	3.1	7.8	-0.1	-2.8	-0.7	2.4	1.2
Average weekly red wine intake	0.5	0.7	2.7	-0.4	-0.7	-0.5	-1.6	0.1
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.6	-0.7	1.2	-1.5	-1.6	-1.1
Mood swings	1.1	1.9	5.5	-1.5	-2.3	-0.7	1.1	-0.5
Loneliness, isolation	0.6	0.8	1.6	-1.2	0.2	-1.3	0.2	-0.8
Long-standing illness, disability or infirmity	1.6	2.4	6.0	-0.3	-2.4	-2.0	-1.0	-1.1
Ever had bowel cancer screening	4.5	5.3	10.2	-1.0	-1.0	-2.6	-3.2	-2.7
Diabetes diagnosed by doctor	1.0	1.6	5.3	-0.8	-2.3	-0.5	1.2	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.2	-0.9	0.1	-1.5	-0.3	-0.9
Friendships satisfaction	0.7	0.9	1.7	-1.1	-0.6	-1.1	-0.1	-1.3
Qualifications: nursing, teaching	0.3	0.4	1.2	1.1	0.0	0.3	0.4	0.8
Commuting to job workplace: Walk	3.4	3.6	7.3	-0.7	1.1	-1.8	-2.7	-2.4
Eye problems/disorders: Cataract	2.1	2.4	4.1	-1.5	-0.9	-0.9	-2.0	-2.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	2.4	-1.6	-1.1	-1.6	-0.9	-1.5
Medication for cholesterol	0.6	0.9	2.0	-1.0	-0.8	-0.8	1.4	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	-0.2	-0.6	-0.6	0.1	-0.3
Back pain experienced in last month	1.6	2.3	3.7	-1.5	-1.1	-1.4	-1.5	-1.9
Mineral and other dietary supplements	0.4	0.5	1.0	1.0	0.4	0.7	0.4	0.8
Breast cancer (self-reported)	0.1	0.1	0.2	0.2	-0.3	0.4	-0.5	-0.2
Asthma (self-reported)	0.4	0.9	3.1	1.0	-1.8	0.3	0.4	0.1
Osteoporosis (self-reported)	3.0	3.7	8.4	-1.6	-0.3	-2.2	-1.6	-2.9
Osteoarthritis (self-reported)	0.9	1.2	1.4	-0.8	1.2	-1.1	-1.2	-1.1
Medication: Aspirin	1.2	1.6	3.6	-0.5	-1.2	-1.3	-1.9	-1.1
Medication: Gliclazide	0.6	0.7	2.8	0.5	-1.7	-0.2	-0.2	-0.4
Illnesses of father: None of the above (group 1)	1.8	2.2	5.5	-0.3	2.3	1.0	2.1	0.5
Smoking status: Current	0.2	0.4	1.5	-0.4	0.1	-0.2	1.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.4	1.8	-0.1	1.3	-0.3	1.7
Whole body water mass	0.8	4.4	10.1	0.2	-3.1	0.2	3.2	1.4
Leg predicted mass (right)	0.9	5.0	13.5	0.2	-3.0	0.3	3.7	1.5
Arm fat mass (left)	1.2	4.8	12.2	-0.2	-3.5	-0.7	3.2	1.2
Number of self-reported non-cancer illnesses	0.3	0.6	2.9	0.1	-1.7	0.1	-0.3	-0.1
Average weekly champagne plus white wine intake	0.6	0.9	2.7	0.8	0.8	-0.6	-1.7	0.2
Miserableness	0.5	0.9	2.0	-0.7	-1.4	-1.3	0.4	-0.3
Guilty feelings	2.7	4.1	10.0	-3.2	-0.4	-1.7	-0.1	-2.8
Wears glasses or contact lenses	0.9	1.0	1.6	-1.1	-0.7	-1.2	0.7	-1.2
Ever taken oral contraceptive pill	1.8	2.0	4.1	0.4	-1.4	0.6	1.9	2.0
Hearing aid user	1.1	1.2	4.0	-0.6	-2.0	-0.9	0.1	-1.1
Mother’s age at death	0.4	0.5	1.8	-0.5	-0.1	-0.2	-1.3	-0.7
Financial situation satisfaction	2.5	3.1	5.1	-2.0	-2.3	-1.7	0.7	-1.8
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.2	-1.1	-0.8	-1.0	0.8	-0.9
Commuting to job workplace: Public transport	0.7	0.8	2.1	-0.5	1.4	-0.0	1.2	-0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	0.2	0.2	0.4	-0.8	0.4
Medication: Blood pressure	0.4	0.7	3.1	0.7	-0.0	0.1	-1.8	0.0
Pain type(s) experienced in last month: Hip pain	2.0	2.5	3.7	-1.9	-1.8	-1.4	-0.6	-1.9
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.9	-0.4	0.1	-0.1	-1.0	-0.5
High cholesterol (Self-reported)	0.4	0.8	3.4	-0.1	0.3	-0.0	-1.8	-0.6
Medication: Bendroflumethiazide	0.6	1.0	3.0	1.2	0.7	0.2	-1.7	-0.1
Medication: Paracetamol	1.9	2.9	5.1	-2.1	-1.9	-0.4	2.3	-1.1
Medication: Lisinopril	0.3	0.4	1.6	-0.5	-0.0	-0.1	-1.3	-0.2
Medication: Atorvastatin	0.7	0.8	1.3	-0.7	-0.2	-1.0	-1.1	-1.1
Illnesses of father: High blood pressure	1.9	2.4	5.0	-0.5	0.1	-2.2	-2.2	-1.4
Alcohol drinker status: Never	0.2	0.2	0.4	-0.3	0.6	-0.2	0.3	-0.6
Ever smoked	0.8	1.4	4.4	0.3	-2.1	1.0	0.5	1.0
Basal metabolic rate	0.9	5.1	12.3	0.2	-3.3	0.2	3.5	1.6
Leg fat percentage (left)	0.9	3.2	7.1	0.5	-2.7	0.2	2.3	1.8
Arm fat-free mass (left)	0.9	4.7	11.2	0.3	-3.0	0.3	3.3	1.6
Number of operations (self-reported)	0.9	1.3	2.2	-0.9	-1.0	-1.0	-1.5	-1.1
Average weekly beer plus cider intake	0.6	0.9	4.3	-0.2	-0.3	0.4	2.1	0.2
Irritability	1.4	2.3	8.3	-0.2	-2.9	1.3	1.0	0.9
Risk taking	1.0	1.5	2.5	1.2	-0.5	1.6	0.9	1.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.8	-0.3	-0.9	-0.2	0.0	-0.1
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.0	0.6	-0.4	-0.5	-0.6
Age started oral contraceptive pill	4.3	5.4	11.5	-2.3	-0.8	-2.1	-2.4	-3.4
Diastolic blood pressure, automated reading	0.5	1.6	4.2	2.1	-1.2	0.7	-0.7	1.2
Ever depressed for a whole week	1.3	1.6	3.6	-1.9	-0.8	-1.1	-0.8	-1.4
Unable to work because of sickness or disability	3.4	4.4	9.2	-3.0	-0.3	-2.7	-0.1	-2.4
Commuting to job workplace: Cycle	0.1	0.2	0.3	0.0	0.5	-0.6	-0.0	-0.5
Myopia	1.0	1.5	3.7	0.6	-1.0	-1.4	-1.9	-0.7
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.7	-1.1	-0.3	0.1	1.6	-0.1
Cholesterol lowering medication	1.2	1.7	3.5	-1.1	-1.3	-0.9	-1.9	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.6	-0.6	-1.3	-0.2	-0.9	-0.7
Pain experienced in last month	2.5	4.2	6.1	1.5	2.5	2.0	1.9	2.2
Supplements: Calcium	1.5	1.7	3.8	-2.0	0.4	-0.8	0.3	-1.9
Basal cell carcinoma (self-reported)	1.1	1.4	2.2	0.6	-1.4	1.5	1.2	1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.5	-0.5	0.1	-1.2	-1.2	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	2.6	0.8	-1.4	1.6	0.8	1.2
Heart disease (siblings)	0.7	0.9	1.5	-0.2	-1.0	-1.2	-1.2	-0.7
Alcohol drinker status: Previous	1.2	1.3	3.0	-1.7	0.4	-0.9	1.2	-1.2
Pack years of smoking	0.7	1.1	1.8	-1.1	-0.3	-1.1	-1.1	-1.3
Impedance of whole body	0.6	2.9	11.6	0.4	3.4	0.2	-1.7	-0.1
Leg fat mass (left)	1.3	5.0	12.3	0.4	-3.5	-0.1	3.1	1.8
Arm predicted mass (left)	0.9	4.7	10.6	0.2	-3.2	0.3	3.3	1.6