Hub : Genes

RP11-335G20.7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.2150	0.0650	1.2e-05	0.026	NA	0.073	NA	0.049	3.1e-03	NA	1.3e-06	NA	7.6e-05
2	GTEx	Brain Hypothalamus	0.2970	0.0980	7.8e-03	-0.010	NA	-0.010	NA	0.001	6.6e-01	NA	6.5e-01	NA	3.0e-01
3	GTEx	Breast Mammary Tissue	0.2260	0.0700	1.7e-04	0.097	NA	0.089	NA	-0.003	1.2e-05	NA	2.4e-05	NA	5.3e-01
4	GTEx	Breast Mammary Tissue (Male)	0.0782	0.0971	2.6e-01	-0.007	NA	-0.013	NA	0.094	5.0e-01	NA	1.0e+00	NA	3.6e-03
5	GTEx	Breast Mammary Tissue (Female)	0.4741	0.1013	4.5e-06	0.194	NA	0.095	NA	0.057	1.9e-06	NA	9.0e-04	NA	8.9e-03
6	GTEx	Cells Transformed fibroblasts	0.5590	0.0570	0.0e+00	0.124	NA	0.199	NA	0.186	1.6e-09	NA	7.4e-15	NA	6.1e-14
7	GTEx	Lung	0.1575	0.0745	8.6e-03	-0.004	NA	-0.003	NA	-0.004	9.7e-01	NA	7.4e-01	NA	9.9e-01
8	GTEx	Nerve Tibial	0.4284	0.0846	1.1e-04	0.091	NA	0.115	NA	0.133	5.7e-07	NA	1.7e-08	NA	1.2e-09
9	GTEx	Spleen	0.5910	0.1480	7.5e-03	0.179	NA	0.060	NA	0.251	2.4e-05	NA	1.2e-02	NA	4.0e-07
10	GTEx	Whole Blood	0.4040	0.0610	5.6e-14	0.101	NA	0.140	NA	0.010	1.4e-09	NA	7.5e-13	NA	3.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.5	0.8	4.5	0.9	2.1	-0.4	0.3	0.7	0.6	0.9	-0.0	-0.2	0.7
Bipolar Disorder or Schizophrenia	0.4	1.1	2.7	1.6	0.1	0.7	0.9	1.0	1.5	1.1	0.3	0.1	1.4
Depressed Affect (Nagel 2018)	0.6	1.3	11.8	0.2	-3.4	-0.1	0.5	0.2	0.6	0.1	-0.4	0.0	0.9
Depression (Nagel 2018)	0.1	0.2	0.9	0.1	-0.9	-0.1	0.4	0.2	0.0	0.5	0.0	-0.5	-0.1
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.3	-1.9	-0.2	-2.0	-2.1	-1.9	-1.6	-0.9	-0.0	-0.4	-1.6
Neuroticism (Nagel 2018)	0.3	0.6	4.4	-0.2	-2.1	-0.9	-0.3	-0.7	-0.4	-0.1	-0.2	-0.4	-0.1
Schizophrenia (2018)	0.6	1.2	2.7	1.3	-1.6	1.2	1.0	0.8	1.4	0.3	0.7	0.4	1.3
Schizophrenia vs Biploar Disorder	0.4	0.5	1.9	0.7	-0.2	1.0	0.0	0.0	1.0	0.1	-0.2	-0.6	1.4
Worry (Nagel 2018)	0.7	1.4	3.6	-0.7	-1.1	-1.8	-1.3	-1.9	-1.2	0.3	-0.4	-1.2	-0.7
Alzheimer’s Disease (in mother)	2.0	2.3	5.6	-1.5	0.2	-2.0	-1.9	-1.6	-1.6	-2.4	0.7	-0.4	-1.5
Alzheimer’s Disease (in father)	0.3	0.3	1.2	-0.1	0.2	0.4	-0.0	0.7	-0.7	-1.1	-0.4	0.1	-0.6
Alzheimer’s Disease (including proxy)	1.4	2.0	5.8	-1.1	0.5	-1.4	-1.6	-0.8	-2.0	-2.4	0.6	0.1	-1.8
Crohns Disease (2017)	0.2	0.3	1.6	0.3	-0.9	0.1	0.6	0.3	0.4	-1.2	-0.1	-0.1	0.6
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	-0.1	-0.6	0.1	0.6	0.1	0.2	-0.8	-0.3	-0.6	0.7
Ulcerative Colitis (UC)	0.2	0.4	1.1	-0.1	-0.4	0.8	0.9	0.2	0.2	0.4	-0.4	-0.9	1.1
Major Depression (MDD)	4.5	5.4	10.4	2.8	-0.9	2.7	2.9	2.5	3.2	1.8	-0.1	1.1	3.0
Reaction Time	0.2	0.5	1.6	0.4	0.4	0.0	0.7	-0.4	1.0	0.1	-0.4	-1.2	1.0
Verbal and Numeric Reasoning (VNR)	1.1	2.7	4.7	-1.8	0.8	-2.1	-2.2	-2.2	-1.8	-1.6	0.2	-0.1	-1.8
Breast Cancer	1.6	3.9	8.2	-2.2	0.6	-2.0	-2.5	-2.9	-2.7	-1.1	-0.2	-1.0	-2.3
Ovarian Cancer	0.3	0.4	1.2	1.1	0.1	-0.7	-0.0	-0.3	0.6	1.0	0.4	0.8	0.1
Prostate Cancer	3.0	4.3	7.6	-2.8	1.5	-1.9	-2.3	-2.1	-2.4	-1.0	-1.6	-2.3	-2.1
Age at First Birth	0.5	0.8	1.4	-0.2	-0.2	-1.0	-1.2	-1.1	-0.8	-0.5	1.2	1.0	-0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	4.0	-0.3	-2.0	-0.2	-0.5	-0.6	-0.5	-0.7	-0.1	0.3	-0.5
Coronary Artery Disease (CAD)	0.7	0.8	2.9	-0.6	-0.6	-0.3	-0.9	-0.3	-1.5	-0.1	0.0	-1.7	-0.9
Crohns Disease (2012)	0.4	0.6	2.5	1.0	-1.6	0.4	0.8	0.5	0.7	-0.4	0.3	0.7	0.8
Mean Putamen Volume	0.6	0.7	2.4	0.4	-0.2	1.6	1.2	1.1	0.4	0.7	0.6	0.4	0.4
Fasting Glucose	0.4	0.4	2.3	-0.4	-0.8	-0.1	0.1	0.3	-0.3	0.4	-0.8	-1.5	-0.2
HbA1C	0.1	0.1	0.7	-0.2	0.6	-0.2	-0.3	-0.8	-0.1	0.2	0.2	-0.0	0.1
HDL Cholesterol	0.6	0.9	3.0	-0.9	-0.7	-0.8	-0.6	-1.7	-0.9	-1.2	0.6	0.2	-1.1
LDL Cholesterol	11.4	18.0	38.2	-5.2	1.8	-6.2	-5.6	-5.8	-4.2	-2.8	-0.6	-2.0	-4.1
Lupus	0.1	0.2	0.6	0.2	0.3	0.1	0.2	0.7	0.8	-0.3	-0.5	-0.6	0.5
Neuroticism (2016)	0.3	0.5	0.8	0.8	-0.9	0.8	0.7	0.7	0.5	-0.2	-0.1	0.8	0.7
Primary Biliary Cirrhosis	2.0	2.8	5.0	1.4	1.6	1.3	1.5	2.0	2.2	2.2	1.2	1.1	1.8
Rheumatoid Arthritis	1.7	2.3	4.3	1.7	-1.0	1.6	2.0	1.9	1.6	1.2	0.3	0.6	2.1
Schizophrenia (2014)	0.7	1.4	3.3	1.7	-0.5	1.3	1.4	1.1	1.8	0.6	0.6	0.3	1.5
Triglycerides	1.1	1.9	5.0	-1.7	0.0	-2.2	-2.1	-1.1	-1.0	0.0	-0.2	-1.5	-1.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.0	-0.6	-0.6	0.2	0.1	-0.1	0.3	0.1	0.0	-1.0	0.2
Ulcerative Colitis	0.7	1.0	3.2	0.8	1.3	0.7	0.8	0.9	1.1	1.3	-0.1	-0.2	1.8
Blood Eosinophil Count	0.2	1.3	4.5	0.3	2.1	-0.9	-0.1	0.8	1.8	1.3	-0.3	-0.8	1.3
Blood Platelet Count	12.7	147.0	342.2	11.5	7.2	12.7	15.3	10.2	17.0	12.2	-0.0	2.6	18.5
Blood Red Count	0.8	8.2	22.3	-3.2	-0.1	-3.0	-3.7	-1.4	-4.4	-1.8	-0.1	-1.3	-4.7
Blood White Count	0.1	0.6	3.2	-0.6	1.0	-1.0	-0.6	-1.8	0.4	0.1	-0.1	-0.2	-0.4
Heel T-Score	1.7	13.9	30.1	4.9	-1.5	5.5	4.8	2.9	3.8	2.4	3.0	3.4	3.2
BMI	0.6	3.4	5.4	2.1	1.3	1.7	1.8	2.0	1.9	1.8	1.6	2.3	1.7
Height	1.1	21.0	69.7	-4.4	-1.8	-5.7	-5.2	-8.3	-3.5	-5.3	-0.5	0.5	-4.0
Waist Hip Ratio (WHR)	0.5	2.2	4.6	0.8	-1.3	1.5	1.5	1.4	1.7	2.1	-1.2	-1.4	1.4
Systolic Blood Pressure	0.6	2.9	8.4	2.2	0.8	1.5	2.3	0.2	1.3	2.9	-0.3	-0.5	2.4
Smoking Status	2.9	7.0	14.7	3.1	0.3	2.4	3.0	2.3	3.5	3.8	1.0	1.0	3.3
Allergy or Eczema	0.2	0.6	4.3	0.0	2.1	-0.3	-0.3	-0.7	0.2	0.0	0.7	0.6	0.2
Cardiovascular Disease	0.3	1.0	3.1	0.4	0.9	-0.2	0.7	-0.2	1.2	1.7	-0.2	-1.1	1.8
Hypothyroidism (self reported)	2.1	4.8	8.8	-2.8	2.3	-3.0	-2.6	-0.9	-2.5	-1.3	-1.3	-2.3	-2.0
Respiratory disease	0.7	1.6	4.6	-1.6	0.5	-0.3	-1.2	-0.4	-2.1	-0.6	-1.3	-1.3	-1.6
Type 2 Diabetes (T2D) (2018)	0.9	1.7	6.1	1.7	0.3	0.3	1.0	0.5	2.5	0.7	1.4	1.4	1.5
Lung FEV1/FVC ratio	0.3	1.7	6.1	2.3	0.3	0.1	0.6	0.1	1.3	2.5	1.1	0.8	1.4
Lung FVC	0.6	3.1	10.7	-1.8	0.2	-2.9	-2.2	-3.3	-1.6	0.3	-0.4	-0.7	-1.1
Neuroticism	0.9	2.3	5.0	1.4	-2.2	-1.1	-0.4	-1.5	1.0	1.6	2.2	1.7	0.8
Chronotype (morning person)	0.9	2.1	7.0	0.8	0.3	2.7	2.4	1.1	1.4	0.4	-0.5	0.3	2.0
Hair Pigment	0.0	1.2	3.7	-0.1	-1.2	1.4	0.7	1.8	-0.1	0.0	-1.1	-1.9	0.0
Tanning	0.0	0.2	0.6	-0.2	-0.1	0.3	-0.2	-0.8	-0.6	-0.3	0.3	0.5	-0.7
Hand grip strength (left)	0.6	1.7	2.6	-1.6	-0.8	-1.0	-1.5	-1.6	-1.5	-1.5	-0.5	0.4	-1.6
Number of treatments/medications taken	0.2	0.3	1.0	0.2	-0.1	0.4	0.9	0.3	0.9	-0.6	0.0	0.1	1.0
Average weekly spirits intake	0.3	0.4	1.2	-0.3	-0.6	0.5	0.2	0.5	-0.6	-0.4	-1.1	-0.6	-1.1
Sensitivity / hurt feelings	0.0	0.1	0.3	0.1	-0.4	0.0	0.0	0.6	-0.0	-0.6	-0.0	-0.1	0.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.6	-0.4	-1.3	-0.4	-0.2	0.4	-0.4	-0.3	0.1	-0.5	-0.3
Hearing difficulty/problems: Yes	3.8	5.8	8.9	2.9	-1.6	3.0	2.7	2.9	2.9	2.2	0.3	0.8	2.8
Relative age of first facial hair	0.1	0.3	1.4	-0.1	0.4	-0.1	0.3	0.6	0.0	1.2	0.6	-0.1	0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	0.1	-0.5	-0.7	-0.5	-1.0	-0.4	0.4	0.8	-0.1	-0.5
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.4	-1.1	0.9	-1.1	-1.0	-0.9	-0.4	-1.2	-0.9	-0.1	-0.8
Ever had hysterectomy (womb removed)	0.5	0.6	3.6	0.6	-1.0	-0.0	0.4	1.9	0.1	0.6	-0.5	-0.5	0.3
Systolic blood pressure, automated reading	0.2	0.5	2.0	0.9	-0.1	-0.0	0.5	-0.9	0.4	1.4	0.4	0.7	0.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.7	1.2	0.7	1.0	0.9	1.3	1.0	1.1	0.1	-0.9	0.8
Angina	1.4	1.9	4.3	1.2	-1.8	2.1	2.0	1.6	0.6	-0.1	-0.5	-0.1	1.5
Medication for hormone replacement therapy	0.4	0.4	1.6	-1.3	-1.2	-0.6	-0.3	-0.3	-0.0	-0.5	-0.3	-0.4	-0.1
Vitamin and mineral supplements	0.6	0.7	2.3	0.6	1.4	0.5	0.2	1.5	0.6	1.1	0.6	0.2	0.8
Supplements: Zinc	0.4	0.5	3.0	-0.0	-1.7	-0.4	0.4	-0.3	0.2	0.6	-0.6	-0.7	0.2
Medication: Co-codamol	1.1	1.3	3.4	1.2	0.1	1.8	1.4	1.8	1.1	0.7	-0.5	-0.6	1.0
Medication: Metformin	0.7	0.9	3.1	0.9	1.7	0.5	0.8	0.5	1.4	0.7	0.6	0.2	1.1
Diabetes (father)	0.8	1.0	2.6	-1.0	-0.4	-1.1	-1.0	-0.5	-0.7	-1.6	1.1	0.4	-1.2
Diabetes (mother)	1.3	1.7	2.7	1.6	0.7	1.2	1.4	1.6	1.4	-0.2	1.4	1.2	1.4
Severe depression (siblings)	1.5	1.6	5.3	-1.2	2.3	-1.8	-1.2	-1.2	-1.3	-0.2	1.2	0.3	-0.8
Pack years adult smoking proportion	1.2	1.9	3.8	1.3	1.2	1.8	1.6	1.4	1.9	0.8	0.0	0.1	1.7
Impedance of leg (right)	2.3	10.9	27.4	-3.1	0.8	-5.2	-4.5	-3.9	-3.3	-2.1	-0.8	-2.6	-3.5
Leg fat-free mass (left)	0.1	0.6	2.4	-0.1	0.4	0.7	0.6	-0.0	1.1	-0.8	-0.0	1.5	0.7
Trunk fat percentage	0.2	0.6	1.3	-0.2	1.1	-1.0	-0.8	0.8	0.5	0.3	1.1	1.1	-0.3
Hand grip strength (right)	0.3	0.7	1.3	-0.8	0.4	-0.6	-1.1	-1.1	-0.9	-0.9	0.3	0.8	-1.1
Townsend deprivation index at recruitment	0.6	0.9	2.0	1.4	-0.2	1.1	1.0	1.0	1.1	1.1	-0.3	-0.4	1.0
Current tobacco smoking	0.4	0.6	3.1	0.8	-0.1	0.1	0.4	-0.0	1.1	1.8	0.1	-0.1	1.2
Average weekly fortified wine intake	2.2	2.6	5.0	-1.5	-1.5	-2.0	-2.2	-1.7	-1.7	-1.6	-0.0	-0.4	-2.0
Maternal smoking around birth	0.5	0.7	2.7	0.5	-0.4	0.3	0.8	0.1	1.6	-0.1	0.7	0.1	1.6
Fed-up feelings	0.2	0.4	1.4	-0.0	-1.2	-1.2	-0.4	-0.1	0.2	-0.8	-0.3	-0.1	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	-0.2	0.3	-0.6	-0.3	-0.5	-0.2	0.4	0.1	-0.4	0.0
Relative age voice broke	0.3	0.4	1.0	-0.0	0.9	-0.2	0.2	0.8	0.3	1.0	-0.4	-0.9	0.5
Taking other prescription medications	0.4	0.6	2.0	-1.1	0.7	-1.4	-0.7	-0.7	-0.2	-1.0	-0.1	-0.4	-0.5
Age when periods started (menarche)	0.2	0.5	2.2	-0.0	1.5	-0.7	-0.4	-0.3	-0.1	-0.7	0.9	0.9	-0.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.6	-0.9	-1.2	-1.3	-1.0	0.8	-1.3	-1.6	0.8	0.0	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	8.6	1.0	-2.6	2.9	2.2	1.2	1.0	-0.7	0.2	1.1	1.3
Tinnitus: Yes, but not now, but have in the past	7.1	7.6	18.1	-2.5	0.8	-4.3	-3.8	-3.2	-2.6	-3.2	-0.2	-0.2	-3.0
Qualifications: CSEs or equivalent	0.2	0.3	1.7	0.2	0.1	0.2	0.7	-0.3	0.4	0.6	0.1	-0.1	1.3
Serious illness, injury or assault to yourself	0.2	0.3	0.9	0.4	-0.4	-0.2	-0.3	-0.8	-0.1	0.5	1.0	0.7	-0.1
High blood pressure	1.2	3.4	8.3	2.5	0.3	1.6	2.2	1.1	2.4	2.1	0.7	0.3	2.9
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.8	-1.4	1.1	-0.8	-1.1	-1.4	-0.9	-1.0	-0.5	-0.8	-0.8
Multivitamins +/- minerals	0.2	0.3	1.5	-0.3	-0.5	-0.5	0.0	-1.2	-0.1	-0.7	-0.3	0.3	-0.1
Stomach or abdominal pain in last month	0.3	0.3	2.4	0.1	0.7	0.1	0.0	0.1	0.2	-1.5	0.3	0.5	-0.0
Supplements: Glucosamine	0.7	0.9	5.4	0.5	-2.3	0.9	0.6	-1.3	0.6	-0.3	-0.4	0.1	0.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	4.5	-0.8	2.1	-0.4	-0.4	-0.1	-1.2	-1.7	0.6	0.0	-0.9
Medication: Atenolol	0.4	0.5	1.5	1.2	0.2	1.1	0.9	0.1	0.7	0.7	0.5	0.3	0.8
Medication: Levothyroxine sodium	0.7	1.3	3.5	-1.3	1.0	-1.4	-1.0	0.3	-1.4	-0.4	-0.7	-1.9	-0.9
Sitting height	0.4	3.1	10.6	-1.6	-1.7	-1.7	-1.3	-3.2	-0.6	-3.0	-0.3	0.4	-0.8
Chronic bronchitis/emphysema (father)	0.2	0.2	0.8	-0.0	0.9	-0.6	-0.5	-0.4	-0.3	-0.7	-0.0	-0.1	-0.6
High blood pressure (mother)	0.9	1.3	4.3	0.7	0.6	1.2	1.3	1.1	1.3	1.3	-0.1	-0.2	2.1
Body mass index (BMI)	0.6	2.7	5.8	1.5	1.1	1.6	1.4	2.4	2.1	1.4	0.9	1.8	1.6
Impedance of leg (left)	2.0	9.6	23.2	-2.9	0.4	-4.8	-4.3	-3.9	-3.4	-1.9	-0.5	-2.3	-3.2
Leg predicted mass (left)	0.1	0.6	2.4	-0.1	0.4	0.6	0.6	-0.0	1.1	-0.9	0.0	1.6	0.7
Trunk fat mass	0.2	0.7	1.8	-0.6	0.7	-1.3	-1.1	-0.1	0.3	-0.4	1.0	1.3	-0.5
Waist circumference	0.3	1.3	3.0	0.7	0.8	0.8	0.9	1.4	1.7	1.5	0.3	1.1	1.3
Number of incorrect matches in round	3.0	5.1	14.5	-2.3	0.6	-3.0	-2.9	-3.8	-2.3	-1.3	0.5	0.1	-2.4
Past tobacco smoking	1.4	2.6	6.4	-1.2	0.3	-2.2	-2.5	-2.5	-1.6	-1.3	0.4	0.6	-1.6
Alcohol usually taken with meals	0.7	1.2	3.0	0.4	0.0	1.7	1.4	1.0	1.0	1.4	0.1	1.2	1.2
Nervous feelings	0.2	0.3	1.2	0.0	0.9	-0.3	-0.2	-0.4	-1.1	0.5	-0.7	-0.2	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	0.2	-0.1	0.3	0.2	1.0	-0.1	-0.8	0.5	0.7	0.1
Hearing difficulty/problems with background noise	2.6	4.2	7.2	2.3	-2.1	2.2	2.3	1.8	2.6	2.2	-0.3	0.1	2.7
Hair/balding pattern: Pattern 2	4.4	5.6	14.1	-2.2	-1.7	-2.8	-3.2	-1.4	-2.2	-2.8	-0.9	-0.7	-3.8
Had menopause	1.4	1.8	5.7	-1.1	1.6	-2.4	-1.9	-1.2	-0.9	-0.2	0.2	-0.2	-1.4
Had other major operations	0.1	0.1	0.5	-0.2	0.3	-0.5	-0.2	0.7	-0.1	-0.1	0.1	0.1	-0.4
Forced vital capacity (FVC)	2.4	9.3	22.8	-3.5	-0.8	-3.9	-3.4	-4.8	-3.2	-3.2	-1.1	-1.1	-2.7
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	11.0	1.7	-2.5	3.3	2.8	1.6	1.9	0.4	0.1	1.3	2.1
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.4	-1.1	-0.4	-1.1	-1.1	-1.6	-1.2	-0.7	0.0	-0.2	-1.1
Qualifications: None of the above	0.9	1.9	4.7	1.5	0.3	1.6	2.1	2.2	1.3	1.1	-0.8	-0.4	1.2
Financial difficulties in last 2 years	0.2	0.3	1.2	0.4	0.6	0.1	0.0	1.1	0.6	-0.4	0.1	-0.2	0.5
Mouth/teeth dental problems	0.1	0.2	0.8	0.4	0.2	0.5	0.5	-0.3	0.1	0.0	0.9	0.4	0.2
Heart attack	0.2	0.2	0.6	0.3	0.7	0.8	0.6	0.3	0.6	0.4	0.3	-0.2	0.4
Allergy	0.6	1.5	3.2	1.8	-0.6	0.9	1.3	0.9	1.5	1.5	1.1	1.1	1.1
Pain all over the body in last month	0.6	0.6	2.9	0.4	-1.7	0.4	0.7	0.4	0.8	0.6	-0.6	-0.0	1.1
Diabetes (self-reported)	0.4	0.7	2.3	0.5	1.3	-0.1	0.2	0.0	1.5	0.2	1.0	0.4	1.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.2	-1.2	0.1	-1.0	-0.6	-1.8	-0.3	-0.6	-0.8	-1.2	-0.4
Medication: Ramipril	0.1	0.2	1.4	-0.3	-0.2	0.2	-0.1	-0.2	0.1	-1.2	-0.4	-0.4	0.1
Medication: Simvastatin	1.2	1.7	5.2	-1.6	-0.5	-1.5	-1.3	-1.6	-0.8	-2.3	-0.2	-0.4	-1.4
Fluid intelligence score	0.8	1.6	2.9	-1.5	1.2	-1.2	-1.7	-1.3	-1.3	-1.3	0.4	0.3	-1.6
Illnesses of siblings	0.4	0.5	1.6	-0.4	1.3	-0.6	-0.4	0.8	-0.5	-1.2	0.0	0.7	-0.5
Neuroticism score	0.4	0.8	3.8	-0.3	-2.0	-1.2	-0.8	-1.0	-0.6	-0.0	0.1	-0.5	0.2
Weight	0.1	0.5	2.5	-0.3	0.5	-0.5	-0.4	-0.3	0.8	-0.6	0.5	1.6	0.1
Impedance of arm (right)	0.2	1.0	4.4	-0.6	0.1	-2.1	-1.4	-0.5	-0.9	0.2	0.1	-1.2	-1.0
Arm fat percentage (right)	0.4	1.7	5.2	1.2	1.2	0.7	0.7	2.3	1.5	1.2	1.2	1.6	0.7
Trunk fat-free mass	0.3	1.6	6.0	-1.4	-0.5	-0.7	-0.9	-2.4	-0.3	-2.3	-0.6	0.8	-0.7
Hip circumference	0.2	0.7	3.0	-0.5	1.7	-0.6	-0.4	0.2	0.4	0.1	0.8	1.5	-0.0
Time employed in main current job	0.1	0.1	0.3	0.4	-0.2	0.2	0.4	-0.2	-0.2	0.5	0.4	0.0	-0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.6	-0.2	-0.0	-0.4	-0.3	0.3	-0.3	-0.0	-0.8	-0.6	-0.7
Father’s age at death	0.4	0.5	2.8	0.6	-1.0	0.6	0.3	0.4	-0.1	-0.2	0.3	1.7	0.0
Worrier / anxious feelings	0.1	0.2	0.6	0.5	-0.5	0.3	0.3	-0.8	-0.6	0.4	0.4	0.4	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.3	-0.5	-0.7	-0.6	0.1	0.2	-0.1	0.1	-0.4	0.0
Falls in the last year	0.2	0.3	1.0	-0.3	-1.0	-0.6	-0.4	0.1	-0.8	0.5	-0.5	-0.5	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	1.1	0.4	0.4	0.1	0.8	0.3	-0.2	0.3	-0.3	-0.4	1.0
Number of live births	0.1	0.2	0.7	0.2	0.0	0.3	0.2	0.8	0.4	0.6	0.3	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1)	2.1	7.1	16.8	-2.8	0.1	-3.8	-3.2	-4.1	-2.8	-2.5	-0.9	-1.2	-2.5
Pulse rate	1.5	2.5	7.4	1.1	0.1	1.9	2.0	1.3	2.5	0.5	-0.3	-0.1	2.7
Happiness	0.4	0.5	1.3	0.3	1.1	0.1	0.2	0.5	0.9	-0.0	0.8	1.0	0.8
Noisy workplace	0.4	0.5	1.8	0.2	-0.1	-1.0	-0.0	-0.5	1.3	-0.2	0.4	0.2	1.3
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.2	-1.3	-0.8	-0.3	-0.8	-1.3	-1.8	-1.6	-0.0	0.7	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	3.2	-1.5	-0.4	-1.3	-1.2	-0.7	-0.6	-1.8	-0.4	-0.8	-0.8
Mouth/teeth dental problems: Dentures	1.8	3.0	6.7	1.2	-1.1	2.6	2.2	2.4	2.0	1.0	-1.3	-0.2	1.9
Asthma	1.1	2.1	4.8	-1.9	0.3	-1.2	-1.9	-1.0	-2.2	-1.3	-0.6	-1.1	-1.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.1	0.4	-0.2	0.1	-0.0	-0.2	0.3	-0.1	0.8	1.0	0.4
Medication: Cholesterol lowering	1.2	1.8	4.8	-1.9	-0.6	-1.3	-1.3	-0.9	-1.4	-2.2	-0.3	-0.9	-1.5
Depression (self-reported)	0.6	0.7	2.0	0.9	0.8	-0.4	0.5	-0.0	1.4	1.4	0.3	-0.2	1.1
Medication: Lansoprazole	0.5	0.6	1.3	-0.5	0.9	-0.1	-0.1	0.2	-1.1	0.2	-1.1	-1.1	-0.9
Prospective memory result	0.3	0.4	1.3	0.5	-0.7	1.1	1.1	-0.3	0.4	0.1	-0.1	-0.0	0.6
Lung cancer (father)	0.7	0.8	2.1	0.9	1.4	1.0	1.1	0.5	0.9	0.7	-0.3	0.4	1.1
Illnesses of mother	1.1	1.4	4.4	-0.8	-0.8	-1.1	-1.1	-1.0	-2.1	-0.5	-0.5	-0.3	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.9	18.3	-2.4	-0.1	-3.6	-2.8	-4.3	-2.1	-2.0	-0.6	-0.9	-2.1
Pulse wave Arterial Stiffness index	0.4	0.4	1.5	-0.5	0.3	-0.2	-0.4	0.4	-0.8	-1.2	0.4	0.7	-0.9
Impedance of arm (left)	0.4	1.9	6.7	-1.1	0.3	-2.6	-1.9	-1.1	-1.4	0.2	0.2	-1.2	-1.6
Arm fat mass (right)	0.2	1.0	3.0	0.7	1.0	0.5	0.4	1.5	1.3	0.4	0.9	1.7	0.6
Trunk predicted mass	0.3	1.5	6.0	-1.3	-0.3	-0.6	-0.8	-2.4	-0.3	-2.2	-0.6	0.8	-0.6
Standing height	1.2	12.2	33.6	-4.0	-1.2	-4.4	-3.9	-5.8	-2.7	-4.4	-0.9	-0.3	-3.1
Length of working week for main job	3.3	3.7	12.4	1.4	0.4	2.1	1.8	3.5	1.7	2.3	-0.7	-0.2	2.3
Exposure to tobacco smoke at home	1.2	1.4	4.0	-1.1	2.0	-1.4	-1.1	0.2	-1.2	-0.9	-0.5	-1.1	-1.2
Breastfed as a baby	2.3	2.8	7.5	1.5	-0.4	2.3	2.4	2.7	1.4	1.1	-0.9	0.1	1.9
Tense / ‘highly strung’	3.0	4.9	9.5	-2.2	-1.0	-3.1	-2.9	-2.8	-2.6	-2.0	-0.6	-1.7	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.9	0.2	-0.4	-0.5	0.4	-0.2	0.3	-0.0	-0.6	-0.6	0.9
Hair/balding pattern: Pattern 4	4.1	10.0	19.0	3.8	4.2	3.9	4.1	2.6	1.6	4.4	0.8	-0.0	2.6
Birth weight of first child	0.3	0.5	2.0	-0.5	-0.4	-0.3	-0.5	-1.4	-0.9	-0.4	-0.6	-0.5	-0.7
Peak expiratory flow (PEF)	1.1	2.4	4.0	-1.1	1.8	-2.0	-1.9	-1.9	-1.6	-1.2	-0.9	-0.7	-1.9
Pulse wave reflection index	1.7	2.0	5.1	-1.0	1.9	-1.2	-1.5	-0.9	-2.1	-0.9	0.4	0.8	-2.3
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.5	-0.8	2.1	-1.4	-1.0	-1.1	0.4	-0.1	-0.7	-1.1	0.3
Loud music exposure frequency	0.2	0.2	0.5	0.3	-0.0	-0.7	-0.6	-0.4	0.2	0.5	0.3	-0.6	-0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.3	-0.1	1.1	0.4	0.2	0.2	-0.3	-0.4	0.7	0.6	0.0
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	7.3	-1.4	0.6	-2.3	-2.2	-2.7	-1.7	-0.5	0.2	-0.2	-1.7
Blood clot in the leg (DVT)	0.1	0.1	0.5	0.0	0.1	0.3	0.3	0.7	0.0	-0.6	-0.5	-0.1	-0.3
Medication: Paracetamol	0.2	0.3	2.8	0.3	-1.7	-0.4	-0.1	-0.4	0.3	0.0	-0.1	-0.0	0.2
Headache pain in last month	0.2	0.3	0.5	0.7	-0.7	0.4	0.5	-0.7	0.4	0.5	0.1	-0.7	0.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	1.4	0.3	0.2	-0.3	-0.1	-0.0	0.3	1.2	-0.1	0.5	0.4
Glaucoma (self-reported)	0.1	0.1	0.4	-0.6	0.5	-0.0	0.2	0.4	-0.1	0.6	-0.2	-0.2	-0.0
Gout (self-reported)	0.2	0.3	1.4	-0.5	-0.1	-1.2	-0.7	-0.4	-0.1	-0.3	-0.3	0.3	-0.6
Hypothyroidism/myxoedema (self-reported)	1.8	3.6	6.4	-2.3	2.0	-2.5	-2.2	-0.4	-2.4	-1.1	-0.7	-1.8	-1.9
Medication: Amlodipine	1.1	1.5	2.8	1.6	0.3	1.7	1.4	1.3	1.3	1.1	0.7	0.7	1.4
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.9	0.3	-0.7	0.0	0.2	-0.5	0.8	0.6	0.1	-0.3	0.9
Birth weight	1.4	2.9	5.5	2.1	-2.0	2.1	2.3	2.0	1.9	0.7	-0.7	-0.0	1.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.9	0.1	0.6	0.5	0.3	1.2	1.4	-0.2	0.2	-0.2	0.8
High blood pressure (siblings)	0.3	0.5	2.4	-0.2	-1.6	-0.4	-0.7	-1.1	-0.4	0.1	0.3	-0.4	-0.5
Forced vital capacity (FVC), Best measure	2.3	8.5	24.5	-3.1	-0.9	-3.9	-3.3	-5.0	-2.7	-2.8	-1.0	-0.9	-2.6
Body fat percentage	0.2	0.7	1.3	-0.1	1.1	-1.0	-0.8	0.8	0.4	0.4	1.1	1.1	-0.3
Leg fat percentage (right)	0.3	0.9	2.9	-0.5	1.6	-1.7	-1.4	0.0	-0.1	0.2	0.7	0.5	-0.8
Arm fat-free mass (right)	0.2	1.1	3.6	-1.2	-0.1	-0.4	-0.8	-1.9	-0.3	-1.8	-0.3	1.0	-0.5
Exposure to tobacco smoke outside home	0.6	0.8	3.3	0.7	0.8	0.5	0.9	1.8	1.0	-0.2	-0.3	0.2	1.1
Comparative body size at age 10	3.2	8.7	18.6	2.6	-1.0	4.2	3.5	4.3	3.2	2.7	-0.2	2.1	3.0
Number of full brothers	0.7	0.9	1.9	-1.0	-1.2	-1.4	-1.0	-0.3	-0.4	0.2	-1.1	-1.2	-0.1
Worry too long after embarrassment	0.2	0.3	1.6	0.3	-1.3	0.0	0.1	-0.3	0.2	-0.8	0.0	0.2	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.3	-1.4	-0.9	-1.8	-1.0	-1.2	-0.7	-0.4	-0.6	-1.2	-0.2
Wheeze or whistling in the chest in last year	0.3	0.5	3.8	-0.3	-1.9	0.4	-0.2	-0.0	-0.2	-0.1	-0.5	-0.0	-0.6
Number of children fathered	0.2	0.2	1.0	0.4	-0.0	-0.3	-0.1	1.0	-0.1	0.6	0.9	0.3	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	6.8	-0.5	-2.6	-1.3	-1.2	-1.4	-0.8	-1.8	-0.4	0.2	-1.2
Age at first live birth	0.1	0.2	0.7	0.4	0.8	0.2	0.1	-0.2	-0.2	0.7	0.1	0.2	0.2
Pulse wave peak to peak time	0.3	0.3	0.7	0.2	-0.6	-0.1	0.1	-0.7	0.6	0.8	-0.4	-0.7	0.6
Health satisfaction	0.3	0.4	1.7	0.5	0.0	0.2	0.2	0.7	0.6	1.3	0.6	0.2	1.0
Shortness of breath walking on level ground	0.2	0.2	0.7	-0.7	0.9	-0.2	0.0	0.3	-0.0	0.6	-0.2	-0.1	0.7
Qualifications: College or University degree	0.5	1.5	3.3	-1.0	-0.3	-0.3	-1.3	-1.8	-1.5	-1.4	0.9	0.9	-1.6
Eye problems/disorders: None of the above	0.8	0.9	2.2	0.8	0.7	0.7	0.7	0.7	1.2	0.7	0.7	1.5	1.4
Mouth/teeth dental problems: Loose teeth	3.6	4.3	8.2	2.8	-1.2	1.9	2.5	2.9	2.0	1.2	1.4	2.2	1.8
Emphysema/chronic bronchitis	0.3	0.4	1.3	-0.7	1.1	-0.0	-0.4	0.4	-1.0	-0.6	-0.5	-0.0	-0.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.2	-0.5	0.9	-0.4	-0.8	-0.6	-1.1	0.1	-0.2	-0.6	-1.1
Neck or shoulder pain in last month	0.2	0.2	0.6	-0.0	-0.5	-0.1	-0.5	0.8	-0.2	-0.2	0.6	0.3	-0.8
Medication: Blood pressure	1.2	2.2	5.6	2.1	-0.1	2.4	2.3	1.2	1.4	0.2	0.5	0.2	1.7
Angina (self-reported)	1.5	1.9	4.3	1.2	-2.0	2.1	2.0	1.6	0.6	-0.1	-0.5	-0.2	1.4
Migraine (self-reported)	0.9	1.1	2.2	-1.3	-0.1	-1.5	-1.0	-0.8	-1.0	-0.6	-0.2	-1.2	-1.5
Medication: Ibuprofen	0.4	0.4	1.3	-0.4	-0.8	-0.6	-0.8	-0.8	-0.3	-1.1	0.5	0.6	-0.3
Medication: Allopurinol	0.1	0.2	1.1	-0.2	-0.2	-1.0	-0.3	0.2	0.5	-0.4	0.2	-0.1	0.2
Medication: Omeprazole	0.3	0.3	0.9	0.2	-0.4	0.5	0.7	0.5	0.5	-1.0	0.6	0.6	0.1
Medication: Seretide 50 evohaler	0.3	0.3	1.6	-0.4	0.9	-0.0	-0.0	-0.3	-0.6	-1.3	-0.1	0.4	-0.4
Mean time to correctly identify matches	0.1	0.2	1.0	0.5	0.6	-0.2	0.4	-0.1	0.1	-0.3	-0.2	-1.0	0.1
Heart disease (mother)	0.2	0.2	0.7	-0.0	-0.3	-0.5	-0.2	-0.3	0.9	0.7	0.1	-0.1	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.4	0.6	0.9	0.1	0.4	1.2	0.1	1.0	0.6	0.2	0.1
Whole body fat mass	0.1	0.5	1.8	-0.2	0.8	-0.9	-0.8	0.3	0.5	-0.1	0.9	1.3	-0.2
Leg fat mass (right)	0.2	0.7	1.8	-0.6	1.1	-1.4	-1.1	-0.1	0.3	-0.4	0.7	1.0	-0.4
Arm predicted mass (right)	0.2	1.0	3.5	-1.1	-0.4	-0.3	-0.7	-1.6	-0.2	-1.9	-0.2	1.2	-0.4
Pulse rate, automated reading	0.7	2.3	7.5	1.4	-0.4	1.5	1.6	1.3	2.7	0.8	-0.1	0.3	2.5
Alcohol intake frequency.	0.5	1.1	3.9	0.7	1.9	0.5	0.3	0.6	1.1	2.0	-0.7	-0.3	0.9
Comparative height size at age 10	0.1	0.5	3.3	-0.5	-0.4	0.2	-0.2	-1.8	0.3	-0.5	-0.6	0.9	-0.4
Number of full sisters	1.1	1.3	3.0	1.4	0.8	1.4	1.6	1.7	1.2	0.1	0.5	0.5	1.2
Suffer from ‘nerves’	0.2	0.3	1.0	-0.6	0.3	-1.0	-0.7	-0.8	-0.6	0.0	0.1	-0.5	-0.3
Overall health rating	0.2	0.3	1.6	-0.3	0.5	-1.3	-0.7	-0.8	0.3	0.4	-0.0	-0.3	-0.2
Chest pain or discomfort	0.5	0.7	1.6	-1.1	0.3	-0.6	-0.6	-0.5	-1.0	0.5	-0.9	-1.3	-0.7
Had major operations	0.6	0.7	1.9	-0.6	-0.6	-1.0	-0.9	-0.9	-0.7	-1.4	0.4	0.2	-1.2
Age at last live birth	0.1	0.2	0.7	-0.4	0.8	-0.2	-0.4	-0.1	-0.6	-0.1	0.0	0.2	-0.6
Family relationship satisfaction	0.2	0.3	0.9	-0.1	0.5	-0.1	-0.2	0.1	0.3	-0.9	0.8	0.8	-0.1
Leg pain on walking	0.8	0.9	3.6	1.0	-0.5	0.6	0.9	1.1	0.7	1.9	0.2	-0.2	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	3.8	0.2	-1.9	-0.6	-0.1	-0.2	-0.1	0.1	-1.1	-0.5	0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	0.2	0.7	0.1	0.1	0.0	0.5	0.8	0.4	0.3	0.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.8	-0.9	0.6	-0.3	-0.4	-0.6	-0.8	0.4	0.2	-0.5	-0.6
Medication: Aspirin	0.3	0.4	0.8	0.2	-0.4	0.3	0.9	0.9	0.7	-0.3	0.8	0.7	0.8
Supplements: Vitamin C	0.6	0.7	3.1	-0.7	-1.8	0.2	0.1	-1.3	-0.6	-0.7	-0.2	-0.5	-0.5
Knee pain experienced in last month	0.9	1.4	3.3	1.2	-0.4	1.8	1.8	1.6	0.9	0.7	0.5	0.3	1.0
Hypertension (Self-reported)	1.0	2.9	6.9	2.4	0.4	1.5	2.0	0.8	2.2	2.0	0.9	0.2	2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.3	-0.7	0.7	-0.3	-0.1	-0.6	-0.8	-0.1	-1.1	-1.2	-0.3
Illnesses of father: Heart disease	0.5	0.6	2.6	0.2	0.5	-1.6	-0.8	-1.0	-0.6	-0.1	0.9	0.3	-0.6
Illnesses of siblings: Diabetes	0.2	0.2	0.8	-0.1	0.9	-0.4	-0.1	-0.3	0.9	0.1	-0.1	-0.4	0.4
Smoking status: Previous	1.3	1.9	5.7	0.7	-0.1	1.9	2.3	2.4	1.3	0.5	-0.6	-0.5	1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	10.1	-2.2	-1.4	-2.3	-2.1	-3.2	-1.1	-2.3	-0.4	-0.8	-1.2
Whole body fat-free mass	0.1	0.7	2.9	-0.8	-0.0	0.0	-0.2	-1.4	0.3	-1.7	-0.3	1.2	0.0
Leg fat-free mass (right)	0.2	1.0	3.3	0.3	0.0	1.2	1.1	0.3	1.4	-0.6	0.2	1.8	1.1
Arm fat percentage (left)	0.4	1.5	4.7	0.9	1.2	0.5	0.4	2.2	1.2	1.3	1.2	1.5	0.5
Average weekly red wine intake	0.1	0.2	0.5	-0.4	-0.6	0.5	0.4	0.5	-0.6	-0.1	-0.1	0.1	-0.7
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.2	-1.4	0.8	-1.5	-0.9	-1.3	-0.4	-0.6	-0.5	-1.2	-0.9
Mood swings	0.8	1.4	4.0	0.8	-2.0	0.8	1.1	1.5	1.2	0.6	-0.3	0.1	1.8
Loneliness, isolation	0.2	0.3	1.1	0.1	-0.0	0.4	0.8	1.1	0.5	0.3	-0.5	-0.1	0.7
Long-standing illness, disability or infirmity	0.2	0.3	0.8	0.5	0.8	0.6	0.7	0.2	0.9	-0.1	0.1	0.1	0.8
Ever had bowel cancer screening	0.6	0.7	3.2	0.3	0.4	1.2	0.8	1.8	-0.1	-0.6	-0.0	0.9	0.1
Diabetes diagnosed by doctor	1.1	1.8	4.8	1.1	2.2	0.5	0.9	0.5	2.1	0.9	1.1	0.4	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.2	-0.7	0.9	-0.9	-1.1	-0.8	-0.2	0.5	-0.0	-0.2	-0.7
Friendships satisfaction	1.2	1.5	6.5	0.9	0.5	1.5	1.5	2.5	0.6	0.4	0.6	1.0	0.7
Qualifications: nursing, teaching	1.1	1.8	3.7	-0.9	0.5	-0.7	-1.7	-1.1	-1.2	-1.7	1.4	1.4	-1.9
Commuting to job workplace: Walk	0.3	0.3	1.3	1.1	-0.5	0.6	0.7	0.6	0.5	-0.4	0.3	0.4	-0.0
Eye problems/disorders: Cataract	1.1	1.2	2.2	-1.1	-0.9	-1.0	-1.2	-1.2	-1.4	-0.4	-0.6	-1.4	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.6	-0.7	0.6	-1.3	-1.6	-0.6	-1.4	-1.6	0.8	0.5	-1.5
Medication for cholesterol	0.3	0.5	1.2	0.5	0.8	0.7	0.0	0.9	-0.9	-0.6	0.4	0.2	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.7	-1.1	0.9	-0.8	-1.0	-0.2	-1.3	-0.6	-1.9	-1.9	-1.2
Back pain experienced in last month	0.5	0.7	2.3	1.0	0.7	0.2	0.6	1.5	0.9	0.4	0.1	0.4	1.1
Mineral and other dietary supplements	0.9	1.2	6.7	-0.2	2.6	-0.1	0.0	1.5	0.2	1.6	-0.2	-0.6	0.3
Breast cancer (self-reported)	0.6	0.8	1.5	1.1	-0.7	1.2	1.2	0.5	1.0	0.8	0.1	-0.7	0.8
Asthma (self-reported)	0.9	1.9	3.9	-1.8	0.5	-1.0	-1.7	-0.9	-2.0	-1.4	-0.6	-1.1	-1.7
Osteoporosis (self-reported)	0.4	0.5	1.9	0.0	0.9	-0.5	-0.3	-0.6	-0.6	1.4	0.3	-0.1	-0.8
Osteoarthritis (self-reported)	0.1	0.1	0.6	0.8	0.0	0.4	-0.1	-0.0	-0.0	0.2	0.3	0.4	-0.5
Medication: Aspirin	0.4	0.5	1.1	0.4	-0.6	0.6	1.0	1.0	0.8	-0.7	0.7	0.5	0.8
Medication: Gliclazide	0.4	0.4	2.1	0.3	1.4	0.5	0.6	0.4	0.5	0.4	0.9	0.3	0.5
Illnesses of father: None of the above (group 1)	0.2	0.2	1.0	-0.6	-0.4	-0.0	-0.6	-1.0	0.2	-0.2	-0.7	-0.2	0.0
Smoking status: Current	0.6	0.9	3.7	1.1	-0.4	0.2	0.6	0.2	1.3	1.9	0.3	0.1	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	5.9	-1.0	-0.5	-1.7	-1.4	-2.4	-1.3	-1.3	0.4	0.3	-1.1
Whole body water mass	0.1	0.7	3.2	-0.8	0.0	0.1	-0.2	-1.4	0.2	-1.8	-0.2	1.2	-0.0
Leg predicted mass (right)	0.2	0.9	3.2	0.2	0.0	1.2	1.0	0.3	1.3	-0.7	0.2	1.8	1.1
Arm fat mass (left)	0.3	1.1	3.4	0.7	0.9	0.4	0.4	1.5	1.4	0.7	1.1	1.8	0.6
Number of self-reported non-cancer illnesses	0.5	0.9	3.3	-0.6	1.8	-0.9	-0.5	-0.7	-0.6	-1.5	-0.1	-0.4	-0.6
Average weekly champagne plus white wine intake	1.6	2.2	5.1	1.5	0.2	2.3	2.1	1.6	1.5	1.1	-0.2	0.7	2.0
Miserableness	1.3	2.3	5.8	1.2	-1.7	1.6	1.9	1.4	1.9	0.4	-0.4	0.1	2.4
Guilty feelings	0.6	0.9	1.7	-0.8	-1.1	-1.3	-1.1	-0.7	-1.2	-0.8	-0.4	-1.1	-0.9
Wears glasses or contact lenses	0.7	0.8	1.9	-0.7	-1.4	-1.1	-1.0	0.0	-1.4	-0.8	0.0	-0.1	-1.1
Ever taken oral contraceptive pill	0.5	0.5	3.4	-0.5	0.2	0.4	0.0	0.2	-0.6	-1.8	-0.8	-0.1	-0.6
Hearing aid user	1.1	1.2	3.5	0.4	-1.2	0.8	1.1	0.3	1.2	1.9	-0.3	-1.0	1.6
Mother’s age at death	0.1	0.1	0.5	-0.1	0.7	0.6	0.3	-0.0	-0.0	0.1	-0.3	-0.1	-0.3
Financial situation satisfaction	0.7	0.8	3.2	-1.1	-0.5	-1.8	-1.3	-1.1	-0.5	0.3	-0.0	0.0	-0.5
Tinnitus: Yes, now most or all of the time	1.7	2.0	5.1	1.2	-2.2	1.4	1.6	1.5	1.2	1.5	-0.7	0.1	1.4
Commuting to job workplace: Public transport	0.4	0.5	2.0	-0.6	-1.4	-0.4	-0.7	-0.3	-0.7	-0.2	-0.7	0.1	-1.0
Eye problems/disorders: Glaucoma	0.7	0.9	2.3	0.4	-0.4	1.2	1.3	1.5	0.9	0.9	0.1	-0.4	1.1
Medication: Blood pressure	0.6	1.1	3.1	1.1	-0.0	0.8	0.9	0.1	1.4	1.8	0.2	0.4	1.7
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.5	-0.2	-0.7	0.5	0.2	-0.7	-0.3	-0.1	0.2	-0.2	-0.2
Supplements: Fish oil (including cod liver oil)	1.5	2.0	8.1	-0.4	-1.2	-0.6	-0.9	-1.9	-1.1	-2.8	0.7	1.5	-1.2
High cholesterol (Self-reported)	2.0	3.5	12.0	-2.6	0.3	-3.5	-2.5	-2.0	-0.8	-1.4	-0.6	-1.1	-1.2
Medication: Bendroflumethiazide	1.3	1.9	5.3	2.3	-1.7	0.5	1.4	-0.4	1.8	0.8	0.1	1.0	1.9
Medication: Paracetamol	0.9	1.4	2.2	-1.1	-1.4	-1.5	-1.5	-1.2	-1.3	-1.1	-0.3	-0.5	-1.3
Medication: Lisinopril	3.4	4.4	8.5	2.5	0.6	2.9	2.9	1.9	2.4	2.0	0.4	0.3	2.6
Medication: Atorvastatin	0.2	0.2	0.9	-0.8	1.0	-0.1	0.1	0.6	-0.2	0.3	0.2	-0.0	0.5
Illnesses of father: High blood pressure	0.5	0.6	1.8	0.6	-0.5	0.6	0.6	1.4	-0.0	1.2	1.0	0.1	0.5
Alcohol drinker status: Never	0.5	0.6	3.4	0.1	1.8	0.7	0.5	0.7	0.8	-0.2	-0.6	0.5	0.6
Ever smoked	1.1	2.0	4.4	1.2	-0.3	1.9	2.1	1.5	1.5	1.8	-0.4	-0.8	1.4
Basal metabolic rate	0.1	0.7	2.5	-0.7	0.2	-0.1	-0.3	-1.2	0.4	-1.6	-0.1	1.4	-0.0
Leg fat percentage (left)	0.2	0.7	1.8	-0.2	1.3	-1.3	-1.1	0.3	0.0	0.3	1.0	0.8	-0.5
Arm fat-free mass (left)	0.1	0.7	2.7	-0.5	-0.1	-0.0	-0.3	-1.4	0.3	-1.6	-0.0	1.3	0.0
Number of operations (self-reported)	0.8	1.1	3.5	-0.9	-0.5	-1.1	-0.9	-0.4	-1.3	-1.9	0.1	0.2	-1.7
Average weekly beer plus cider intake	0.4	0.5	1.0	-0.6	0.1	-1.0	-0.8	-0.7	-0.5	-0.6	-0.7	-0.8	-1.0
Irritability	0.1	0.2	1.1	-0.5	-1.0	-0.3	-0.5	-0.4	-0.3	-0.3	0.1	0.0	0.1
Risk taking	0.1	0.1	0.3	-0.0	-0.2	0.1	-0.5	0.5	0.3	0.1	-0.2	-0.2	-0.5
Ever had prostate specific antigen (PSA) test	1.3	1.5	5.5	-0.8	0.7	-0.0	-0.9	-1.4	-1.7	-1.6	-0.1	0.6	-2.4
Fractured/broken bones in last 5 years	0.3	0.3	1.0	0.0	-1.0	-0.4	-0.5	0.8	0.1	-0.5	-0.7	-0.6	-0.3
Age started oral contraceptive pill	0.4	0.5	2.0	-0.1	0.4	-0.5	-0.6	-1.2	-0.7	-0.2	0.3	1.4	-0.5
Diastolic blood pressure, automated reading	0.3	0.9	1.5	1.1	-0.9	0.8	0.9	0.1	1.1	1.2	0.8	0.5	1.1
Ever depressed for a whole week	2.1	2.6	5.9	-1.9	-0.1	-2.4	-2.1	-2.1	-1.0	-1.8	0.6	-0.0	-1.5
Unable to work because of sickness or disability	0.1	0.1	0.5	0.7	-0.1	0.0	0.1	-0.2	0.5	0.5	-0.1	-0.2	0.5
Commuting to job workplace: Cycle	0.3	0.4	1.4	0.5	-0.3	1.2	0.5	0.5	0.1	-1.1	0.4	0.8	0.1
Myopia	0.7	1.1	2.1	-1.4	0.8	-1.2	-1.4	-0.3	-1.4	-0.8	0.4	0.2	-1.3
Vascular/heart problems diagnosed by doctor	1.3	3.5	8.1	-2.5	-0.2	-1.9	-2.2	-1.4	-2.2	-2.0	-0.5	-0.1	-2.9
Cholesterol lowering medication	1.0	1.5	5.2	-1.9	0.1	-2.3	-1.6	-1.5	-0.3	-1.0	-0.0	-0.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	2.0	-0.3	-0.3	0.0	0.3	-0.1	0.3	-1.4	0.3	0.6	-0.1
Pain experienced in last month	0.2	0.3	2.1	-0.2	1.4	0.3	-0.1	0.2	-0.1	-0.0	0.2	0.5	-0.2
Supplements: Calcium	0.4	0.4	2.2	0.1	0.7	0.0	0.3	0.6	0.4	1.0	-0.3	-1.5	0.2
Basal cell carcinoma (self-reported)	1.2	1.4	3.3	0.6	1.8	0.8	1.4	0.8	1.1	1.6	-1.1	-0.6	1.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	0.5	0.6	1.0	0.8	0.3	0.8	0.4	0.3	-0.0	0.6
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.3	-0.0	0.5	0.5	0.5	0.2	-0.5	-0.4	-0.2	-0.2
Heart disease (siblings)	0.7	0.9	3.2	0.6	-1.6	0.7	0.6	0.2	0.0	1.8	-0.5	-0.8	0.7
Alcohol drinker status: Previous	0.4	0.4	1.7	0.4	1.3	0.4	0.3	0.4	0.4	1.3	0.1	0.4	0.5
Pack years of smoking	1.0	1.5	2.7	1.3	1.2	1.6	1.4	1.4	1.7	0.9	0.1	-0.0	1.5
Impedance of whole body	0.9	4.7	13.4	-1.9	0.2	-3.7	-3.0	-2.2	-2.4	-0.9	-0.0	-1.8	-2.4
Leg fat mass (left)	0.2	0.6	1.4	-0.5	1.0	-1.2	-1.0	0.1	0.3	-0.4	0.9	1.2	-0.4
Arm predicted mass (left)	0.2	0.8	3.0	-0.7	-0.1	-0.2	-0.5	-1.4	0.1	-1.7	-0.0	1.3	-0.2