Hub : Genes

RP11-375N15.2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Hypothalamus 0.220 0.115 0.0072 0.268 NA 0.170 NA 0.224 5.2e-07 NA 8.8e-05 NA 5.6e-06
2 GTEx Colon Transverse 0.086 0.040 0.0033 0.095 NA 0.061 NA 0.073 2.8e-05 NA 7.5e-04 NA 2.4e-04
3 GTEx Small Intestine Terminal Ileum 0.356 0.113 0.0004 0.202 NA 0.132 NA 0.141 2.7e-05 NA 7.3e-04 NA 4.9e-04
4 GTEx Testis 0.123 0.057 0.0048 0.013 NA 0.035 NA 0.018 8.4e-02 NA 1.1e-02 NA 5.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.5 2.4 3.0 -1.6 1.6 1.7 1.1
Bipolar Disorder or Schizophrenia 2.8 6.9 9.4 -3.1 3.0 2.4 1.9
Depressed Affect (Nagel 2018) 2.2 4.6 6.3 2.2 1.4 2.5 2.3
Depression (Nagel 2018) 3.0 4.6 5.8 2.4 1.8 1.9 2.4
Intelligence (Savage-Jansen 2018) 0.3 1.0 2.5 1.6 -1.0 -0.8 0.1
Neuroticism (Nagel 2018) 1.8 4.3 6.2 1.9 1.6 2.3 2.5
Schizophrenia (2018) 2.2 4.6 6.9 -2.6 2.6 1.6 1.5
Schizophrenia vs Biploar Disorder 2.9 3.9 6.1 -2.0 1.9 1.3 2.5
Worry (Nagel 2018) 0.8 1.6 2.8 1.0 0.7 1.4 1.7
Alzheimer’s Disease (in mother) 0.9 1.0 1.7 -0.7 1.2 1.3 0.6
Alzheimer’s Disease (in father) 0.8 0.9 1.5 -1.2 -1.2 -0.8 0.0
Alzheimer’s Disease (including proxy) 0.0 0.1 0.1 0.4 -0.1 0.3 0.1
Crohns Disease (2017) 1.7 3.8 6.5 -0.8 2.1 2.6 1.8
Irritable Bowel Disease (IBD) 1.1 2.7 6.4 -1.0 1.4 2.5 1.2
Ulcerative Colitis (UC) 0.5 0.9 2.6 -0.9 0.4 1.6 0.4
Major Depression (MDD) 2.1 2.5 4.3 -0.2 2.1 2.1 1.3
Reaction Time 0.9 1.7 5.6 0.9 0.7 0.3 2.4
Verbal and Numeric Reasoning (VNR) 0.5 1.2 3.9 2.0 -0.8 -0.4 0.4
Breast Cancer 1.5 3.7 6.0 0.0 2.4 1.7 2.4
Ovarian Cancer 0.2 0.3 0.4 0.2 0.6 -0.4 0.7
Prostate Cancer 4.2 5.9 10.6 0.2 3.1 1.8 3.3
Age at First Birth 1.7 2.4 3.2 1.7 -1.8 -1.6 -1.0
Bipolar Disorder (2011) 3.1 3.0 5.0 -0.1 2.2 2.1 1.6
Body Mass Index (BMI) (2010) 1.6 2.2 4.0 -0.7 2.0 1.3 1.6
Coronary Artery Disease (CAD) 1.3 1.6 3.7 0.1 1.4 1.9 0.8
Crohns Disease (2012) 3.8 6.1 9.6 -1.0 3.0 3.1 2.3
Mean Putamen Volume 3.4 3.9 7.9 0.2 1.9 2.8 2.0
Fasting Glucose 0.7 0.8 1.9 1.0 1.4 0.5 0.3
HbA1C 0.4 0.5 1.2 -0.6 1.1 0.6 0.2
HDL Cholesterol 1.3 2.2 5.4 -2.3 0.5 1.6 0.8
LDL Cholesterol 0.8 1.2 1.9 -1.0 0.4 1.3 1.4
Lupus 3.2 4.8 7.4 -0.4 2.7 2.3 2.5
Neuroticism (2016) 1.6 2.3 7.2 2.7 -1.0 -0.4 -0.9
Primary Biliary Cirrhosis 0.4 0.5 1.4 -0.3 1.2 0.0 0.7
Rheumatoid Arthritis 0.1 0.2 0.5 -0.0 0.5 0.2 0.7
Schizophrenia (2014) 4.0 8.9 13.3 -2.6 3.6 2.8 2.8
Triglycerides 8.3 13.6 17.6 3.9 -3.2 -3.4 -4.2
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.1 -1.5 0.6 -0.6 0.1
Ulcerative Colitis 0.1 0.2 0.6 0.1 -0.1 -0.4 -0.8
Blood Eosinophil Count 0.1 0.9 2.4 -0.2 -1.5 -0.6 -0.8
Blood Platelet Count 0.3 4.0 7.1 0.3 2.4 2.7 1.7
Blood Red Count 0.8 7.5 18.4 1.3 -2.1 -2.4 -4.3
Blood White Count 0.8 5.9 11.2 -1.9 2.7 3.4 1.3
Heel T-Score 1.9 15.3 21.3 2.5 -4.4 -4.6 -3.7
BMI 0.1 0.3 0.7 -0.9 0.4 0.6 -0.2
Height 0.4 8.3 13.9 2.2 -2.9 -2.5 -3.7
Waist Hip Ratio (WHR) 0.1 0.4 0.9 0.2 1.0 0.6 -0.6
Systolic Blood Pressure 0.1 0.4 1.0 -1.0 0.7 -0.4 0.0
Smoking Status 0.2 0.5 1.0 0.2 1.0 0.8 -0.5
Allergy or Eczema 0.1 0.1 0.4 -0.6 -0.2 0.2 -0.3
Cardiovascular Disease 0.6 1.9 2.8 0.5 1.7 1.6 1.4
Hypothyroidism (self reported) 0.4 1.0 2.0 -0.7 -1.4 -0.5 -1.1
Respiratory disease 0.4 0.9 1.6 0.6 -1.2 -0.4 -1.3
Type 2 Diabetes (T2D) (2018) 1.2 2.3 3.8 1.3 -1.3 -2.0 -1.5
Lung FEV1/FVC ratio 0.2 1.0 2.1 -1.4 -1.2 -0.6 -0.0
Lung FVC 0.4 2.2 7.6 2.7 1.0 0.2 -0.4
Neuroticism 2.0 4.8 6.8 1.4 1.9 2.6 2.6
Chronotype (morning person) 1.0 2.3 4.2 -1.2 1.3 2.0 1.3
Hair Pigment 0.0 1.2 2.4 -0.2 1.4 1.6 0.8
Tanning 0.0 0.1 0.2 0.2 -0.0 0.3 0.4
Hand grip strength (left) 0.9 2.3 5.6 -0.1 -1.1 -1.5 -2.4
Number of treatments/medications taken 3.5 6.2 10.2 -0.2 2.5 3.2 2.9
Average weekly spirits intake 0.6 0.8 2.1 -0.6 -0.7 -1.5 0.4
Sensitivity / hurt feelings 3.6 6.1 7.1 2.5 -2.5 -2.3 -2.7
Frequency of depressed mood in last 2 weeks 3.1 4.4 16.5 4.1 -0.4 0.9 0.5
Hearing difficulty/problems: Yes 0.1 0.2 0.5 -0.7 0.5 0.3 0.2
Relative age of first facial hair 1.1 2.3 4.1 -0.1 -1.3 -1.8 -2.0
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 2.2 -0.8 1.5 1.3 1.1
Ever used hormone-replacement therapy (HRT) 1.4 1.8 3.6 -0.9 1.5 1.9 0.9
Ever had hysterectomy (womb removed) 0.6 0.7 1.2 0.3 1.1 0.8 1.0
Systolic blood pressure, automated reading 5.2 15.1 23.3 -3.9 4.8 3.0 3.6
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.0 -0.8 1.0 1.2 1.4
Angina 1.6 2.1 4.0 -0.8 1.2 2.0 1.5
Medication for hormone replacement therapy 1.6 1.8 3.6 -1.2 1.2 1.9 0.9
Vitamin and mineral supplements 2.0 2.7 4.5 0.9 -1.8 -2.1 -1.6
Supplements: Zinc 1.5 1.6 2.0 1.1 1.3 1.3 1.4
Medication: Co-codamol 0.3 0.4 1.0 0.3 0.5 0.5 1.0
Medication: Metformin 0.8 1.2 3.1 0.2 1.8 0.8 1.0
Diabetes (father) 1.7 2.1 4.8 -2.2 0.8 0.9 1.4
Diabetes (mother) 0.2 0.3 0.9 0.1 0.9 0.5 -0.3
Severe depression (siblings) 1.0 1.2 2.5 -0.4 0.7 1.2 1.6
Pack years adult smoking proportion 3.0 4.6 10.2 -0.1 2.2 1.8 3.2
Impedance of leg (right) 2.9 13.9 21.6 4.6 -4.4 -3.0 -2.4
Leg fat-free mass (left) 0.7 3.5 8.6 -2.9 1.9 1.3 0.2
Trunk fat percentage 2.3 9.1 12.9 -3.6 2.8 2.7 2.9
Hand grip strength (right) 1.4 3.8 8.1 -0.1 -1.5 -2.2 -2.8
Townsend deprivation index at recruitment 0.3 0.4 0.9 -0.1 0.5 0.7 1.0
Current tobacco smoking 2.6 4.2 7.0 0.1 2.6 2.0 2.4
Average weekly fortified wine intake 3.6 4.2 9.7 0.6 -3.1 -1.8 -1.9
Maternal smoking around birth 0.3 0.4 1.2 -0.0 -0.3 -0.7 -1.1
Fed-up feelings 1.9 3.5 10.7 3.3 -1.8 0.1 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 2.9 3.9 15.3 3.9 -0.4 -0.4 0.0
Relative age voice broke 2.4 3.7 5.0 1.5 -1.9 -2.2 -2.0
Taking other prescription medications 0.2 0.4 1.1 -0.2 0.5 1.0 -0.2
Age when periods started (menarche) 1.4 3.5 5.5 1.3 -1.4 -2.3 -2.2
Bilateral oophorectomy (both ovaries removed) 3.0 3.4 4.8 -1.5 1.9 2.2 1.7
Heel bone mineral density (BMD) T-score, automated (left) 6.5 14.7 17.8 -4.2 4.0 3.2 3.8
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.4 -0.7 0.9 0.6 1.2
Qualifications: CSEs or equivalent 0.5 0.7 1.0 -0.6 0.7 1.0 1.0
Serious illness, injury or assault to yourself 1.9 2.3 4.0 -0.7 1.4 2.0 1.7
High blood pressure 8.3 23.2 38.9 -3.2 6.2 4.5 4.9
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.4 -0.2 0.2 0.7 -0.2
Multivitamins +/- minerals 0.1 0.1 0.5 0.7 0.2 0.1 0.2
Stomach or abdominal pain in last month 0.7 0.9 3.0 1.7 -0.7 -0.2 -0.2
Supplements: Glucosamine 0.9 1.1 1.9 1.4 -0.9 -0.2 -1.3
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.4 0.2 0.3 -0.4 0.6
Medication: Atenolol 2.8 3.5 4.3 -1.3 2.1 2.0 2.0
Medication: Levothyroxine sodium 3.1 5.2 7.4 1.9 -2.7 -1.7 -2.6
Sitting height 0.1 1.0 2.6 -1.6 1.0 0.7 0.0
Chronic bronchitis/emphysema (father) 0.3 0.3 0.9 1.0 -0.3 -0.5 0.2
High blood pressure (mother) 0.6 0.8 2.3 0.2 1.5 0.7 0.4
Body mass index (BMI) 4.8 20.5 28.4 -5.3 4.9 4.2 3.5
Impedance of leg (left) 3.0 14.5 22.0 4.7 -4.5 -3.1 -2.4
Leg predicted mass (left) 0.7 3.6 8.5 -2.9 2.0 1.4 0.3
Trunk fat mass 1.7 7.3 11.9 -3.4 2.6 2.5 2.1
Waist circumference 0.6 2.2 4.0 -2.0 1.5 1.5 0.6
Number of incorrect matches in round 0.2 0.3 0.5 -0.6 -0.4 -0.7 -0.5
Past tobacco smoking 2.7 5.0 8.3 2.6 -2.9 -1.9 -1.1
Alcohol usually taken with meals 0.7 1.1 1.7 -0.6 1.3 1.0 1.2
Nervous feelings 5.9 11.1 15.6 3.7 -3.9 -2.6 -3.0
Frequency of tenseness / restlessness in last 2 weeks 2.4 3.7 5.1 2.3 1.5 2.0 1.9
Hearing difficulty/problems with background noise 0.4 0.6 1.0 0.9 -0.3 0.7 -1.0
Hair/balding pattern: Pattern 2 1.4 1.8 3.4 -0.3 1.6 1.9 1.1
Had menopause 0.3 0.4 1.0 -0.5 -0.6 -0.3 -1.0
Had other major operations 1.6 1.9 3.3 -0.9 1.8 1.4 1.3
Forced vital capacity (FVC) 1.8 6.9 9.2 3.0 -2.0 -2.3 -3.0
Heel bone mineral density (BMD) T-score, automated (right) 7.0 16.1 25.4 -5.0 3.9 2.8 4.0
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 0.9 0.9 1.0 0.7 0.9
Qualifications: None of the above 2.1 4.5 5.6 -2.4 2.2 2.1 1.8
Financial difficulties in last 2 years 1.0 1.4 3.2 -0.7 1.8 0.9 1.0
Mouth/teeth dental problems 7.2 11.0 19.2 1.6 -3.6 -3.0 -4.4
Heart attack 0.6 0.8 2.3 0.5 0.8 1.5 0.1
Allergy 0.5 1.2 2.5 0.8 -1.1 -1.6 -0.8
Pain all over the body in last month 2.5 2.6 3.4 1.2 1.7 1.7 1.8
Diabetes (self-reported) 0.1 0.2 0.5 0.4 0.7 -0.1 -0.1
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.4 0.5 -1.2 -0.2 -1.5
Medication: Ramipril 4.8 6.2 9.3 -2.1 3.0 2.4 2.3
Medication: Simvastatin 2.3 3.4 5.5 0.0 2.0 2.3 2.0
Fluid intelligence score 0.6 1.3 2.2 1.3 -1.5 -1.1 -0.4
Illnesses of siblings 2.0 2.8 5.5 1.6 -2.3 -1.2 -1.4
Neuroticism score 6.5 13.6 23.1 4.8 -4.3 -2.3 -2.8
Weight 1.2 5.8 11.6 -3.4 2.4 2.2 1.0
Impedance of arm (right) 2.1 10.0 15.3 3.4 -3.9 -3.0 -2.1
Arm fat percentage (right) 3.8 15.0 20.1 -4.5 4.1 3.5 3.3
Trunk fat-free mass 0.2 1.0 2.7 -1.0 0.3 0.2 -1.6
Hip circumference 1.7 7.4 10.0 -3.2 2.8 2.5 2.2
Time employed in main current job 3.4 4.0 4.3 1.9 -2.1 -2.0 -2.0
Alcohol intake versus 10 years previously 0.5 0.8 2.1 0.9 -0.4 0.3 -1.5
Father’s age at death 8.7 11.7 17.5 2.7 -3.4 -3.2 -4.2
Worrier / anxious feelings 9.6 18.1 24.4 4.9 -4.9 -3.1 -3.9
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 8.1 2.8 0.6 0.7 0.4
Falls in the last year 0.9 1.2 1.9 0.1 1.3 1.2 1.4
Hair/balding pattern: Pattern 3 0.1 0.1 0.4 -0.6 -0.1 0.1 -0.3
Number of live births 0.9 1.3 2.9 -0.7 1.3 1.7 0.4
Forced expiratory volume in 1-second (FEV1) 3.5 11.8 16.3 3.1 -3.4 -3.1 -4.0
Pulse rate 0.1 0.2 0.7 -0.4 -0.2 0.0 0.8
Happiness 1.3 1.6 2.6 1.0 1.0 1.3 1.6
Noisy workplace 0.5 0.6 1.9 -1.4 -0.5 -0.1 -0.4
Qualifications: A levels/AS levels or equivalent 2.1 4.8 6.5 2.0 -2.4 -2.5 -1.7
Serious illness, injury or assault of a close relative in last 2 years 2.4 2.8 5.4 0.7 -2.3 -1.5 -1.8
Mouth/teeth dental problems: Dentures 6.3 10.6 16.4 -2.8 3.6 2.3 4.0
Asthma 0.2 0.4 1.2 -1.1 -0.0 0.3 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 1.9 1.4 -1.0 -0.9 -0.8
Medication: Cholesterol lowering 0.6 1.0 2.7 0.0 0.8 1.6 0.8
Depression (self-reported) 0.2 0.3 0.9 1.0 -0.2 -0.3 0.1
Medication: Lansoprazole 0.4 0.5 1.4 0.6 0.1 0.2 -1.2
Prospective memory result 0.8 1.0 1.7 1.3 -0.0 1.1 1.0
Lung cancer (father) 1.4 1.6 4.2 -0.9 1.2 -0.0 2.1
Illnesses of mother 0.4 0.5 1.3 0.7 0.4 0.4 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 3.3 10.7 13.4 3.1 -3.3 -3.0 -3.7
Pulse wave Arterial Stiffness index 0.2 0.3 0.5 0.5 0.6 0.2 0.7
Impedance of arm (left) 1.4 6.3 10.2 3.2 -2.9 -2.3 -1.1
Arm fat mass (right) 3.5 14.5 19.9 -4.5 4.2 3.4 3.0
Trunk predicted mass 0.2 1.0 2.6 -1.1 0.3 0.2 -1.6
Standing height 1.7 17.0 23.8 3.4 -4.5 -3.5 -4.9
Length of working week for main job 3.9 4.4 6.5 -1.4 2.2 2.6 2.0
Exposure to tobacco smoke at home 0.7 0.8 1.6 1.3 0.4 0.2 -1.1
Breastfed as a baby 1.9 2.3 5.9 1.1 -1.2 -0.8 -2.4
Tense / ‘highly strung’ 4.3 7.2 11.4 3.4 -2.7 -2.3 -2.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 5.9 2.4 -0.4 -0.3 -1.1
Hair/balding pattern: Pattern 4 0.1 0.3 0.6 0.8 0.6 0.5 0.1
Birth weight of first child 1.1 2.0 3.6 0.7 -1.9 -1.6 -1.1
Peak expiratory flow (PEF) 8.6 19.9 33.1 2.9 -4.7 -4.0 -5.8
Pulse wave reflection index 0.2 0.2 0.5 0.7 0.3 -0.4 0.2
Ever highly irritable/argumentative for 2 days 0.5 0.5 0.7 0.8 0.9 0.7 0.5
Loud music exposure frequency 0.1 0.1 0.3 0.3 0.2 0.1 0.6
Qualifications: O levels/GCSEs or equivalent 7.6 12.1 15.7 2.9 -4.0 -3.1 -3.8
Mouth/teeth dental problems: Bleeding gums 4.3 5.5 8.1 -0.6 2.8 2.5 2.8
Blood clot in the leg (DVT) 1.6 2.1 3.4 -0.8 1.9 1.8 1.0
Medication: Paracetamol 0.3 0.4 1.2 1.1 0.1 0.6 0.3
Headache pain in last month 1.4 2.3 7.6 2.8 -0.8 -0.8 -0.7
Medication for cholesterol, blood pressure or diabetes 2.3 3.8 5.8 0.8 -2.4 -2.1 -2.1
Glaucoma (self-reported) 1.9 2.3 7.1 0.6 1.1 0.6 2.7
Gout (self-reported) 0.8 1.1 3.8 -1.9 0.7 0.3 -0.4
Hypothyroidism/myxoedema (self-reported) 6.1 11.8 19.9 2.1 -4.5 -2.9 -3.8
Medication: Amlodipine 1.0 1.5 2.8 -0.8 1.7 0.7 1.4
Medication: Ventolin 100micrograms inhaler 1.0 1.3 3.1 -0.4 1.2 1.8 0.6
Birth weight 0.2 0.5 1.0 -0.2 -0.6 -0.8 -1.0
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.6 0.7 0.1 0.0 -0.6
High blood pressure (siblings) 2.0 2.9 6.2 -1.0 2.5 1.1 1.7
Forced vital capacity (FVC), Best measure 1.8 6.6 8.9 2.6 -2.3 -2.3 -3.0
Body fat percentage 2.9 11.3 14.8 -3.8 3.3 3.1 3.2
Leg fat percentage (right) 2.7 9.8 11.3 -3.4 3.3 3.1 2.7
Arm fat-free mass (right) 0.3 1.5 3.5 -1.9 1.1 1.0 -0.4
Exposure to tobacco smoke outside home 0.2 0.3 0.6 -0.2 0.8 0.7 -0.1
Comparative body size at age 10 1.8 5.0 7.5 -0.8 2.7 2.2 2.7
Number of full brothers 1.8 2.3 5.6 -0.0 1.8 0.7 2.4
Worry too long after embarrassment 2.0 3.4 5.9 2.4 -2.0 -1.5 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.8 1.4 0.8 0.9 1.2 0.7
Wheeze or whistling in the chest in last year 1.9 3.5 4.5 -2.0 2.1 1.9 1.2
Number of children fathered 2.9 3.2 6.5 -0.3 2.3 2.6 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 2.5 0.6 0.3 0.7 1.6
Age at first live birth 5.8 10.3 17.1 1.8 -4.1 -3.2 -3.2
Pulse wave peak to peak time 0.4 0.5 1.0 -0.3 -0.9 -0.4 -1.0
Health satisfaction 6.0 7.9 12.4 -1.2 3.4 3.5 2.5
Shortness of breath walking on level ground 3.0 3.6 8.6 -0.9 1.9 2.9 1.1
Qualifications: College or University degree 1.8 5.7 7.6 1.5 -2.8 -2.7 -2.3
Eye problems/disorders: None of the above 0.8 0.9 1.9 -0.5 -1.0 -0.5 -1.4
Mouth/teeth dental problems: Loose teeth 3.8 4.5 6.8 -0.2 2.5 2.1 2.6
Emphysema/chronic bronchitis 10.3 11.7 17.9 -0.1 3.8 4.2 3.8
Medication for pain relief, constipation, heartburn 2.8 4.7 8.3 -0.6 -2.3 -2.9 -2.2
Neck or shoulder pain in last month 0.3 0.4 1.2 -0.1 0.6 0.3 1.1
Medication: Blood pressure 4.8 8.4 14.1 -1.3 3.8 2.7 3.2
Angina (self-reported) 2.3 3.0 5.1 -1.1 1.5 2.3 1.8
Migraine (self-reported) 1.3 1.6 3.1 0.6 -1.5 -1.8 -0.9
Medication: Ibuprofen 0.5 0.6 0.7 0.8 -0.8 -0.7 -0.5
Medication: Allopurinol 1.4 1.9 6.2 -2.5 1.1 0.3 -0.3
Medication: Omeprazole 7.5 8.9 11.4 -1.8 3.4 3.3 3.2
Medication: Seretide 50 evohaler 0.2 0.2 0.8 0.3 -0.1 0.9 -0.3
Mean time to correctly identify matches 1.6 3.1 8.8 0.4 1.6 1.0 3.0
Heart disease (mother) 0.3 0.4 1.1 -1.1 -0.4 0.3 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.6 4.3 7.9 2.8 -2.4 -1.6 -1.0
Whole body fat mass 2.3 9.4 12.5 -3.5 3.2 2.9 2.5
Leg fat mass (right) 2.5 9.6 13.2 -3.6 3.3 2.9 2.4
Arm predicted mass (right) 0.3 1.4 3.0 -1.7 1.2 1.0 -0.5
Pulse rate, automated reading 0.3 0.9 1.8 -1.0 0.9 0.4 1.3
Alcohol intake frequency. 1.7 4.0 9.6 3.1 -1.5 -0.4 -2.0
Comparative height size at age 10 0.1 0.4 0.7 0.9 0.2 0.7 0.6
Number of full sisters 2.0 2.4 4.0 -2.0 1.7 1.3 1.1
Suffer from ‘nerves’ 1.4 2.1 4.6 2.1 -1.7 -0.7 -0.8
Overall health rating 8.8 18.9 28.7 -1.1 5.3 5.4 4.2
Chest pain or discomfort 1.2 1.8 4.0 2.0 0.7 1.3 0.9
Had major operations 0.2 0.3 0.9 -1.0 -0.3 -0.3 -0.2
Age at last live birth 4.0 5.8 11.5 1.3 -3.4 -1.8 -2.7
Family relationship satisfaction 1.1 1.4 2.1 0.7 1.2 1.3 1.4
Leg pain on walking 1.9 2.3 3.2 -0.4 1.6 1.8 1.8
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.7 0.3 -0.8 0.5 -1.3
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.2 -0.3 1.1 0.5 0.6
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.1 0.0 -0.3 -0.4 0.2
Medication: Aspirin 3.6 4.7 7.1 -1.1 2.7 2.4 2.2
Supplements: Vitamin C 6.9 8.2 11.6 -1.7 3.1 3.4 3.0
Knee pain experienced in last month 1.8 2.9 5.5 0.6 1.9 2.4 1.4
Hypertension (Self-reported) 7.6 21.2 36.1 -2.8 6.0 4.3 4.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.1 -0.3 -0.1 0.0 -0.1
Illnesses of father: Heart disease 0.6 0.8 2.3 -0.4 0.5 0.7 1.5
Illnesses of siblings: Diabetes 0.6 0.7 2.4 -1.5 0.4 -0.5 -0.2
Smoking status: Previous 4.0 6.0 11.7 -3.4 2.6 2.0 1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 2.8 1.0 -1.6 -1.4 -1.7
Whole body fat-free mass 0.2 1.4 3.6 -1.9 1.0 0.7 -0.8
Leg fat-free mass (right) 0.6 3.3 8.4 -2.9 1.8 1.2 0.2
Arm fat percentage (left) 4.1 16.4 19.5 -4.4 4.4 3.7 3.7
Average weekly red wine intake 0.4 0.5 0.8 -0.9 0.6 0.7 0.7
Handedness (chirality/laterality): Left-handed 0.8 0.9 1.7 -1.3 0.7 0.8 0.9
Mood swings 3.3 6.0 14.7 3.8 -2.6 -1.1 -1.2
Loneliness, isolation 0.3 0.4 1.0 0.7 -0.0 1.0 0.1
Long-standing illness, disability or infirmity 2.8 4.2 5.3 -1.9 2.3 2.2 1.8
Ever had bowel cancer screening 1.0 1.1 1.7 -0.3 -1.3 -1.1 -1.3
Diabetes diagnosed by doctor 0.4 0.6 1.6 -0.2 1.3 0.7 0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.8 1.9 4.6 -0.3 2.1 1.3 1.1
Friendships satisfaction 1.5 1.9 3.4 0.4 1.6 1.2 1.8
Qualifications: nursing, teaching 2.3 3.6 5.8 1.2 -2.4 -2.2 -1.5
Commuting to job workplace: Walk 1.1 1.1 2.1 1.1 -0.6 -1.4 -1.0
Eye problems/disorders: Cataract 0.1 0.1 0.2 0.4 0.0 0.2 0.2
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.1 1.1 -0.5 -0.3 0.4
Medication for cholesterol 4.5 6.9 10.0 1.8 -2.8 -3.2 -2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.3 2.7 6.3 -1.4 0.8 1.4 2.5
Back pain experienced in last month 1.6 2.4 5.2 0.3 2.3 1.5 1.4
Mineral and other dietary supplements 3.3 4.4 6.8 0.1 -2.6 -2.3 -2.4
Breast cancer (self-reported) 0.5 0.6 2.0 -1.4 0.2 0.4 0.3
Asthma (self-reported) 0.2 0.5 1.7 -1.3 0.2 0.4 -0.2
Osteoporosis (self-reported) 4.1 5.0 8.1 1.6 -2.9 -2.1 -2.3
Osteoarthritis (self-reported) 0.1 0.1 0.4 -0.6 0.1 0.5 -0.1
Medication: Aspirin 3.4 4.4 6.5 -0.8 2.6 2.5 2.1
Medication: Gliclazide 1.6 1.9 3.7 -1.9 0.9 -0.1 1.7
Illnesses of father: None of the above (group 1) 1.7 2.1 3.9 0.5 -1.6 -1.3 -2.0
Smoking status: Current 1.8 2.8 4.9 0.8 2.2 1.4 2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.2 8.8 12.2 3.5 -3.0 -2.3 -2.9
Whole body water mass 0.3 1.6 4.3 -2.1 1.0 0.6 -0.8
Leg predicted mass (right) 0.6 3.2 8.1 -2.8 1.8 1.2 0.1
Arm fat mass (left) 3.5 14.2 19.9 -4.5 4.1 3.4 2.9
Number of self-reported non-cancer illnesses 0.7 1.3 2.0 -0.9 1.1 1.0 1.4
Average weekly champagne plus white wine intake 0.4 0.5 0.8 -0.2 -0.8 -0.9 -0.8
Miserableness 3.9 6.8 18.7 4.3 -2.0 -0.7 -2.0
Guilty feelings 2.7 4.1 7.8 2.8 -2.2 -1.0 -1.7
Wears glasses or contact lenses 3.0 3.5 6.0 0.6 -2.4 -1.7 -2.1
Ever taken oral contraceptive pill 0.6 0.7 1.8 0.2 0.7 0.6 1.3
Hearing aid user 0.7 0.8 1.9 -1.4 0.8 0.4 0.5
Mother’s age at death 4.2 5.3 7.0 2.2 -2.6 -2.4 -1.8
Financial situation satisfaction 2.7 3.3 4.8 -0.3 1.9 2.2 2.2
Tinnitus: Yes, now most or all of the time 0.0 0.0 0.1 0.1 -0.3 0.2 0.1
Commuting to job workplace: Public transport 1.9 2.2 4.4 0.7 -2.1 -1.2 -1.6
Eye problems/disorders: Glaucoma 3.0 3.6 9.0 0.4 1.9 1.3 3.0
Medication: Blood pressure 6.0 11.4 19.1 -2.1 4.4 3.1 3.5
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.3 0.8 1.1 1.1 0.2
Supplements: Fish oil (including cod liver oil) 3.8 4.9 7.9 -1.1 2.8 1.9 2.7
High cholesterol (Self-reported) 5.6 9.9 16.3 0.2 3.3 4.0 3.5
Medication: Bendroflumethiazide 6.5 9.9 14.4 -1.5 3.8 3.4 3.4
Medication: Paracetamol 0.2 0.3 1.0 1.0 0.0 0.2 0.1
Medication: Lisinopril 2.1 2.7 4.6 0.4 2.1 1.6 1.8
Medication: Atorvastatin 1.1 1.4 2.8 -1.2 1.1 1.7 0.4
Illnesses of father: High blood pressure 1.7 2.2 3.5 -1.6 1.9 1.2 1.0
Alcohol drinker status: Never 1.9 2.3 8.3 2.9 -0.5 -0.6 -0.4
Ever smoked 0.3 0.6 1.9 -0.5 1.4 0.1 -0.3
Basal metabolic rate 0.5 2.5 6.0 -2.4 1.6 1.2 -0.1
Leg fat percentage (left) 2.9 10.3 12.6 -3.5 3.3 3.1 2.8
Arm fat-free mass (left) 0.4 2.0 5.5 -2.3 1.3 0.9 -0.4
Number of operations (self-reported) 2.3 3.3 4.5 -2.0 2.1 1.7 1.4
Average weekly beer plus cider intake 4.7 6.8 11.0 1.2 -2.7 -2.7 -3.3
Irritability 7.7 13.1 17.5 4.2 -4.1 -2.7 -3.3
Risk taking 3.9 5.7 9.7 -2.0 3.1 2.7 1.4
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.4 0.2 1.1 1.2 0.9
Fractured/broken bones in last 5 years 0.5 0.7 1.4 1.2 -1.0 0.3 -0.6
Age started oral contraceptive pill 0.4 0.4 1.1 -0.2 -1.1 -0.1 0.8
Diastolic blood pressure, automated reading 5.2 16.0 27.6 -3.5 5.3 3.4 3.6
Ever depressed for a whole week 1.1 1.4 3.9 2.0 0.3 1.1 0.6
Unable to work because of sickness or disability 4.8 6.3 9.2 -1.6 3.0 2.3 2.9
Commuting to job workplace: Cycle 0.7 0.9 2.3 -0.7 -0.8 -0.5 -1.5
Myopia 4.8 7.0 10.1 2.2 -3.2 -2.1 -2.9
Vascular/heart problems diagnosed by doctor 7.4 20.3 32.3 2.9 -5.7 -4.6 -4.4
Cholesterol lowering medication 2.3 3.4 6.1 0.3 2.3 2.5 1.5
Medication: Omeprazole (e.g. Zanprol) 5.2 6.3 9.5 -1.9 3.1 2.5 2.4
Pain experienced in last month 1.8 3.0 4.9 -1.0 -2.2 -2.0 -1.5
Supplements: Calcium 1.7 1.8 2.7 1.1 1.6 1.4 1.3
Basal cell carcinoma (self-reported) 0.8 0.9 2.3 -1.5 0.9 0.6 -0.3
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.2 0.4 0.8 1.5 0.4
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 4.6 -0.8 2.2 2.1 1.1
Heart disease (siblings) 1.5 1.8 2.8 -0.5 1.6 1.3 1.7
Alcohol drinker status: Previous 1.0 1.2 4.5 2.1 -0.3 -0.1 -0.1
Pack years of smoking 2.5 3.7 9.5 -0.4 1.7 1.5 3.1
Impedance of whole body 2.1 10.9 16.3 3.9 -4.0 -2.9 -1.8
Leg fat mass (left) 2.4 9.2 13.4 -3.7 3.2 2.8 2.2
Arm predicted mass (left) 0.4 2.1 5.5 -2.4 1.4 0.9 -0.3