Hub : Genes

RP11-388C12.8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.100 0.035 1.7e-04 0.010 NA 0.03 NA 0.033 0.05300 NA 2.3e-03 NA 1.5e-03
2 GTEx Thyroid 0.088 0.033 8.5e-05 0.045 NA 0.07 NA 0.061 0.00024 NA 5.0e-06 NA 1.9e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.2 0.3 0.7 -0.0 -0.8
Bipolar Disorder or Schizophrenia 0.1 0.2 0.2 0.4 -0.4
Depressed Affect (Nagel 2018) 0.3 0.7 1.4 1.2 0.2
Depression (Nagel 2018) 0.8 1.1 1.3 1.0 1.1
Intelligence (Savage-Jansen 2018) 0.3 0.8 0.9 -0.9 -0.8
Neuroticism (Nagel 2018) 0.2 0.6 1.1 1.0 -0.3
Schizophrenia (2018) 0.1 0.2 0.3 0.5 0.1
Schizophrenia vs Biploar Disorder 0.3 0.3 0.6 0.3 0.8
Worry (Nagel 2018) 0.2 0.4 0.4 0.6 -0.6
Alzheimer’s Disease (in mother) 0.3 0.3 0.5 -0.5 -0.7
Alzheimer’s Disease (in father) 0.1 0.1 0.2 0.5 0.1
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 0.1 -0.5
Crohns Disease (2017) 0.0 0.1 0.1 -0.2 -0.3
Irritable Bowel Disease (IBD) 0.3 0.6 1.1 0.3 1.1
Ulcerative Colitis (UC) 0.7 1.4 2.7 0.2 1.6
Major Depression (MDD) 3.3 4.0 4.3 -2.1 -1.9
Reaction Time 0.2 0.4 0.6 -0.4 -0.8
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.2 0.4 0.4
Breast Cancer 3.7 8.9 9.5 -3.1 -2.9
Ovarian Cancer 0.8 1.0 1.1 1.0 1.0
Prostate Cancer 0.0 0.1 0.1 0.4 -0.0
Age at First Birth 1.7 2.5 3.9 -1.1 -2.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 1.2 1.1 0.6
Coronary Artery Disease (CAD) 0.1 0.1 0.2 -0.2 -0.5
Crohns Disease (2012) 0.4 0.7 1.1 -0.5 -1.0
Mean Putamen Volume 0.1 0.1 0.1 0.4 0.2
Fasting Glucose 4.2 5.1 5.4 2.3 2.2
HbA1C 19.1 21.2 32.0 -3.2 -5.7
HDL Cholesterol 1.1 1.8 1.8 -1.3 -1.3
LDL Cholesterol 0.6 1.0 1.0 1.0 1.0
Lupus 0.1 0.1 0.2 -0.1 0.4
Neuroticism (2016) 0.6 0.8 1.4 -0.5 -1.2
Primary Biliary Cirrhosis 0.5 0.7 1.3 0.3 1.2
Rheumatoid Arthritis 0.5 0.7 1.4 1.2 0.2
Schizophrenia (2014) 0.5 1.1 1.8 1.4 0.6
Triglycerides 0.2 0.3 0.4 0.6 0.4
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.0 -1.0 -0.9
Ulcerative Colitis 0.6 0.9 1.7 -0.1 1.3
Blood Eosinophil Count 0.6 4.4 7.2 -1.3 -2.7
Blood Platelet Count 1.3 14.7 16.6 -3.6 -4.1
Blood Red Count 1.3 12.6 15.3 3.1 3.9
Blood White Count 0.1 0.7 1.3 -1.1 -0.2
Heel T-Score 0.4 3.0 4.4 2.1 1.3
BMI 0.2 0.9 1.5 0.6 1.2
Height 0.9 17.7 21.3 -3.8 -4.6
Waist Hip Ratio (WHR) 0.2 1.0 1.1 -0.9 -1.1
Systolic Blood Pressure 0.5 2.7 4.8 2.2 0.7
Smoking Status 0.5 1.2 1.8 -1.3 -0.7
Allergy or Eczema 1.4 3.7 4.5 -1.7 -2.1
Cardiovascular Disease 0.2 0.7 0.9 0.7 -1.0
Hypothyroidism (self reported) 0.0 0.0 0.0 0.1 -0.2
Respiratory disease 3.5 7.8 8.2 -2.7 -2.9
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.0 -0.1 -0.1
Lung FEV1/FVC ratio 0.2 0.9 1.4 -0.7 -1.2
Lung FVC 0.9 4.7 5.2 2.1 2.3
Neuroticism 0.2 0.5 0.7 0.6 -0.8
Chronotype (morning person) 0.5 1.0 1.1 -1.1 -1.0
Hair Pigment 0.1 3.6 6.0 -1.1 -2.4
Tanning 0.0 0.1 0.1 -0.3 0.2
Hand grip strength (left) 0.1 0.1 0.2 0.3 0.4
Number of treatments/medications taken 1.2 2.2 3.3 -1.0 -1.8
Average weekly spirits intake 0.3 0.3 0.7 -0.8 -0.0
Sensitivity / hurt feelings 0.4 0.8 1.5 1.2 0.2
Frequency of depressed mood in last 2 weeks 0.3 0.5 0.7 -0.9 -0.4
Hearing difficulty/problems: Yes 0.1 0.2 0.3 -0.2 0.6
Relative age of first facial hair 0.2 0.5 0.7 -0.5 -0.9
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.8 0.9 0.2
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 0.2 0.7
Ever had hysterectomy (womb removed) 0.9 1.0 1.8 -1.3 -0.5
Systolic blood pressure, automated reading 0.1 0.2 0.4 0.6 -0.3
Eye problems/disorders: Diabetes related eye disease 2.2 2.4 2.8 1.7 1.4
Angina 1.8 2.4 3.2 -1.3 -1.8
Medication for hormone replacement therapy 0.2 0.2 0.3 -0.6 -0.4
Vitamin and mineral supplements 0.5 0.7 1.3 -1.1 -0.2
Supplements: Zinc 1.4 1.5 2.0 -1.4 -1.0
Medication: Co-codamol 3.5 4.0 4.8 -2.2 -1.8
Medication: Metformin 0.0 0.0 0.0 -0.1 0.1
Diabetes (father) 0.7 0.8 1.4 -1.2 -0.5
Diabetes (mother) 2.9 3.7 4.8 1.6 2.2
Severe depression (siblings) 1.7 1.9 1.9 -1.4 -1.4
Pack years adult smoking proportion 0.2 0.3 0.4 -0.7 0.3
Impedance of leg (right) 0.4 1.9 3.3 -0.7 -1.8
Leg fat-free mass (left) 0.1 0.5 1.0 -1.0 -0.1
Trunk fat percentage 0.0 0.0 0.0 -0.2 0.2
Hand grip strength (right) 0.1 0.4 0.6 -0.3 -0.8
Townsend deprivation index at recruitment 0.1 0.1 0.3 -0.0 0.5
Current tobacco smoking 1.0 1.6 2.5 -1.6 -0.9
Average weekly fortified wine intake 1.3 1.6 1.7 -1.3 -1.2
Maternal smoking around birth 0.3 0.4 0.9 -0.1 0.9
Fed-up feelings 0.0 0.0 0.1 0.0 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.2 0.4 0.4
Relative age voice broke 0.3 0.5 0.8 -0.4 -0.9
Taking other prescription medications 0.3 0.4 0.7 -0.4 -0.8
Age when periods started (menarche) 0.9 2.3 2.6 -1.6 -1.4
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.3 -0.5 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 4.5 2.1 0.3
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.6 0.5 0.7
Qualifications: CSEs or equivalent 0.1 0.1 0.2 -0.2 -0.4
Serious illness, injury or assault to yourself 1.0 1.2 2.3 -1.5 -0.2
High blood pressure 0.7 2.1 4.1 -0.1 -2.0
Hayfever, allergic rhinitis or eczema 1.5 3.2 4.8 -1.2 -2.2
Multivitamins +/- minerals 0.4 0.5 1.0 1.0 0.3
Stomach or abdominal pain in last month 0.6 0.7 1.0 -0.7 -1.0
Supplements: Glucosamine 0.6 0.8 1.0 -1.0 -0.8
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.6 -0.1 -0.8
Medication: Atenolol 1.5 1.9 2.8 -1.1 -1.7
Medication: Levothyroxine sodium 0.0 0.0 0.0 -0.2 -0.0
Sitting height 1.3 9.5 10.3 -2.9 -3.2
Chronic bronchitis/emphysema (father) 0.4 0.4 0.8 -0.9 0.2
High blood pressure (mother) 1.2 1.7 2.1 -1.2 -1.5
Body mass index (BMI) 0.6 2.6 4.4 0.8 2.1
Impedance of leg (left) 0.8 4.0 6.4 -1.2 -2.5
Leg predicted mass (left) 0.1 0.6 1.2 -1.1 -0.2
Trunk fat mass 0.0 0.1 0.2 -0.5 0.1
Waist circumference 0.1 0.2 0.4 -0.6 0.3
Number of incorrect matches in round 0.0 0.0 0.1 -0.0 -0.3
Past tobacco smoking 1.4 2.6 2.9 1.7 1.5
Alcohol usually taken with meals 0.1 0.1 0.3 -0.0 -0.5
Nervous feelings 0.1 0.2 0.4 -0.0 -0.6
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 2.1 -1.1 -1.4
Hearing difficulty/problems with background noise 1.4 2.2 2.8 -1.7 -1.3
Hair/balding pattern: Pattern 2 0.2 0.3 0.5 0.7 0.3
Had menopause 0.6 0.8 1.2 0.6 1.1
Had other major operations 0.0 0.0 0.0 -0.1 -0.1
Forced vital capacity (FVC) 0.0 0.2 0.3 -0.2 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 4.8 2.2 0.6
Ever unenthusiastic/disinterested for a whole week 2.8 3.4 4.2 -1.6 -2.1
Qualifications: None of the above 1.4 3.0 4.6 1.2 2.1
Financial difficulties in last 2 years 0.7 0.9 1.7 0.4 1.3
Mouth/teeth dental problems 0.3 0.4 0.8 -0.9 -0.3
Heart attack 1.6 2.1 2.2 -1.4 -1.5
Allergy 1.9 4.4 5.5 1.8 2.3
Pain all over the body in last month 0.0 0.0 0.0 -0.2 -0.0
Diabetes (self-reported) 0.1 0.2 0.4 -0.6 0.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.4 -0.6 -0.6
Medication: Ramipril 0.2 0.3 0.3 -0.4 -0.6
Medication: Simvastatin 1.7 2.4 3.8 -1.1 -1.9
Fluid intelligence score 0.1 0.1 0.2 0.1 -0.5
Illnesses of siblings 0.3 0.4 0.6 -0.8 -0.5
Neuroticism score 0.5 1.0 1.9 -0.3 -1.4
Weight 0.1 0.4 0.8 -0.9 0.1
Impedance of arm (right) 0.6 2.9 5.1 -0.8 -2.3
Arm fat percentage (right) 0.7 2.7 3.5 1.4 1.9
Trunk fat-free mass 0.1 0.7 1.1 -1.0 -0.6
Hip circumference 0.1 0.6 1.1 -0.2 1.1
Time employed in main current job 1.6 1.8 2.4 1.1 1.6
Alcohol intake versus 10 years previously 0.8 1.2 1.3 -1.1 -1.1
Father’s age at death 0.9 1.2 1.7 0.8 1.3
Worrier / anxious feelings 0.1 0.2 0.4 -0.0 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 0.9 -1.0 -0.8
Falls in the last year 2.9 3.9 4.7 -2.2 -1.7
Hair/balding pattern: Pattern 3 0.4 0.6 1.3 0.1 1.1
Number of live births 0.4 0.5 0.6 0.8 0.7
Forced expiratory volume in 1-second (FEV1) 0.0 0.2 0.3 -0.0 -0.5
Pulse rate 0.1 0.1 0.1 0.3 -0.3
Happiness 0.3 0.4 0.7 -0.9 -0.1
Noisy workplace 0.3 0.3 0.4 -0.6 0.5
Qualifications: A levels/AS levels or equivalent 0.5 1.1 1.9 -0.6 -1.4
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.3 -0.4 -0.6
Mouth/teeth dental problems: Dentures 0.5 0.8 1.0 -0.7 -1.0
Asthma 3.0 5.9 6.7 -2.6 -2.3
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.0 0.1 0.1
Medication: Cholesterol lowering 0.4 0.7 1.3 -0.2 -1.1
Depression (self-reported) 2.4 2.8 4.0 -1.3 -2.0
Medication: Lansoprazole 4.4 5.0 8.0 -2.8 -1.4
Prospective memory result 2.8 3.4 4.9 1.4 2.2
Lung cancer (father) 0.1 0.1 0.2 -0.5 0.1
Illnesses of mother 1.8 2.2 2.6 1.6 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.2 -0.1 -0.5
Pulse wave Arterial Stiffness index 1.5 1.7 2.6 0.9 1.6
Impedance of arm (left) 0.9 4.1 6.2 -1.4 -2.5
Arm fat mass (right) 0.3 1.0 1.6 0.7 1.3
Trunk predicted mass 0.1 0.7 1.1 -1.1 -0.5
Standing height 1.5 15.1 17.6 -3.6 -4.2
Length of working week for main job 0.0 0.0 0.0 0.0 -0.2
Exposure to tobacco smoke at home 0.4 0.5 0.9 -0.9 0.3
Breastfed as a baby 0.7 0.8 1.3 1.1 0.6
Tense / ‘highly strung’ 0.5 0.9 1.2 -0.7 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.6 2.2 -1.0 -1.5
Hair/balding pattern: Pattern 4 0.0 0.0 0.1 0.3 0.1
Birth weight of first child 0.3 0.5 0.9 -1.0 -0.1
Peak expiratory flow (PEF) 0.0 0.0 0.0 0.2 0.1
Pulse wave reflection index 1.0 1.3 1.9 0.8 1.4
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.5 0.6 0.7
Loud music exposure frequency 0.6 0.7 0.8 -0.9 -0.8
Qualifications: O levels/GCSEs or equivalent 0.7 1.2 1.3 -1.0 -1.2
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 0.6 0.2 -0.8
Blood clot in the leg (DVT) 0.0 0.0 0.0 -0.0 0.2
Medication: Paracetamol 0.0 0.0 0.0 -0.2 -0.2
Headache pain in last month 0.7 1.2 2.4 1.5 0.0
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.6 0.2 1.6
Glaucoma (self-reported) 0.0 0.0 0.0 -0.1 0.0
Gout (self-reported) 0.2 0.3 0.5 -0.1 -0.7
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.1 -0.2 -0.3
Medication: Amlodipine 1.9 2.6 4.0 -1.1 -2.0
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.3 -0.6 -0.2
Birth weight 0.1 0.2 0.3 0.4 -0.6
Chronic bronchitis/emphysema (mother) 1.4 1.7 2.4 -1.6 -0.9
High blood pressure (siblings) 0.1 0.1 0.2 -0.2 -0.5
Forced vital capacity (FVC), Best measure 0.1 0.5 0.5 -0.6 -0.7
Body fat percentage 0.1 0.4 0.7 0.3 0.8
Leg fat percentage (right) 0.4 1.4 2.3 0.7 1.5
Arm fat-free mass (right) 0.2 1.1 2.0 -1.4 -0.5
Exposure to tobacco smoke outside home 0.0 0.0 0.1 0.1 -0.2
Comparative body size at age 10 0.1 0.2 0.5 -0.7 -0.1
Number of full brothers 1.6 2.0 2.2 1.4 1.5
Worry too long after embarrassment 0.6 1.1 1.1 -1.0 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 1.3 -0.9 -1.1
Wheeze or whistling in the chest in last year 2.4 4.4 5.3 -2.3 -1.8
Number of children fathered 0.2 0.2 0.3 0.6 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.1 -0.1 -0.4
Age at first live birth 1.5 2.7 3.7 -1.3 -1.9
Pulse wave peak to peak time 2.1 2.5 3.5 -1.2 -1.9
Health satisfaction 0.2 0.3 0.3 0.5 0.5
Shortness of breath walking on level ground 0.6 0.7 1.0 -1.0 -0.6
Qualifications: College or University degree 0.4 1.3 2.1 -0.7 -1.4
Eye problems/disorders: None of the above 1.1 1.3 2.0 -1.4 -0.8
Mouth/teeth dental problems: Loose teeth 6.2 7.3 9.5 -3.1 -2.3
Emphysema/chronic bronchitis 4.2 4.7 4.8 -2.2 -2.2
Medication for pain relief, constipation, heartburn 0.7 1.1 1.8 -1.4 -0.6
Neck or shoulder pain in last month 0.9 1.3 1.3 -1.1 -1.1
Medication: Blood pressure 0.3 0.6 1.2 0.1 -1.1
Angina (self-reported) 1.4 1.8 2.4 -1.1 -1.6
Migraine (self-reported) 0.1 0.1 0.2 0.4 0.2
Medication: Ibuprofen 0.0 0.0 0.0 -0.0 -0.0
Medication: Allopurinol 0.3 0.4 0.7 0.9 0.2
Medication: Omeprazole 3.0 3.6 3.9 -2.0 -1.8
Medication: Seretide 50 evohaler 0.3 0.3 0.5 -0.5 0.7
Mean time to correctly identify matches 0.3 0.5 0.7 -0.8 -0.6
Heart disease (mother) 4.9 6.0 6.2 -2.4 -2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.3 -0.6 0.2
Whole body fat mass 0.1 0.3 0.5 -0.1 0.7
Leg fat mass (right) 0.1 0.4 0.8 -0.1 0.9
Arm predicted mass (right) 0.1 0.6 1.1 -1.1 -0.2
Pulse rate, automated reading 0.3 0.9 1.6 1.2 0.4
Alcohol intake frequency. 1.1 2.5 2.8 1.4 1.7
Comparative height size at age 10 0.2 1.2 1.4 -1.0 -1.2
Number of full sisters 1.0 1.3 2.4 1.5 0.4
Suffer from ‘nerves’ 0.0 0.0 0.0 0.1 -0.2
Overall health rating 1.1 2.4 3.5 -1.2 -1.9
Chest pain or discomfort 5.2 7.5 8.5 -2.5 -2.9
Had major operations 2.0 2.3 2.9 -1.3 -1.7
Age at last live birth 0.7 1.0 1.3 -1.1 -0.8
Family relationship satisfaction 1.5 1.8 1.9 -1.4 -1.3
Leg pain on walking 1.4 1.7 2.1 -1.5 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 0.7 -0.8 -0.4
Commuting to job workplace: Car/motor vehicle 6.2 7.1 7.5 -2.7 -2.6
Illness, injury, bereavement, stress in last 2 years 0.9 1.2 2.3 1.5 0.1
Medication: Aspirin 0.2 0.2 0.4 0.6 -0.0
Supplements: Vitamin C 0.5 0.5 1.0 -0.3 -1.0
Knee pain experienced in last month 0.0 0.1 0.1 0.3 0.1
Hypertension (Self-reported) 0.4 1.2 2.3 0.3 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.9 2.2 -1.5 -1.2
Illnesses of father: Heart disease 1.1 1.5 1.6 -1.3 -1.2
Illnesses of siblings: Diabetes 0.1 0.1 0.1 0.4 -0.2
Smoking status: Previous 0.9 1.4 1.7 -1.3 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.6 5.2 -2.0 -2.3
Whole body fat-free mass 0.1 0.7 1.2 -1.1 -0.4
Leg fat-free mass (right) 0.2 1.1 1.9 -1.4 -0.6
Arm fat percentage (left) 0.5 2.0 2.9 1.1 1.7
Average weekly red wine intake 1.1 1.7 2.0 -1.1 -1.4
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.0 0.0 0.0
Mood swings 0.1 0.1 0.2 0.4 -0.1
Loneliness, isolation 0.2 0.2 0.4 -0.6 -0.3
Long-standing illness, disability or infirmity 0.2 0.3 0.4 -0.5 -0.6
Ever had bowel cancer screening 0.3 0.4 0.4 -0.6 0.6
Diabetes diagnosed by doctor 0.2 0.4 0.7 0.3 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.1 -1.1 -0.3
Friendships satisfaction 0.1 0.1 0.2 -0.1 0.4
Qualifications: nursing, teaching 2.4 3.8 5.6 -1.4 -2.4
Commuting to job workplace: Walk 5.7 6.2 6.5 2.5 2.4
Eye problems/disorders: Cataract 1.4 1.7 2.5 1.6 0.9
Mouth/teeth dental problems: Mouth ulcers 2.8 4.5 5.5 2.4 1.9
Medication for cholesterol 0.4 0.7 0.9 0.6 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 1.1 1.0 1.0
Back pain experienced in last month 1.1 1.6 1.9 -1.4 -1.2
Mineral and other dietary supplements 0.1 0.2 0.3 -0.6 0.0
Breast cancer (self-reported) 3.7 4.5 4.5 -2.1 -2.1
Asthma (self-reported) 3.9 7.8 8.7 -3.0 -2.6
Osteoporosis (self-reported) 0.5 0.7 1.0 -1.0 -0.6
Osteoarthritis (self-reported) 0.8 1.1 1.4 -1.2 -0.9
Medication: Aspirin 0.1 0.1 0.2 0.4 -0.2
Medication: Gliclazide 0.1 0.2 0.3 0.3 0.5
Illnesses of father: None of the above (group 1) 2.6 3.2 3.7 1.9 1.6
Smoking status: Current 0.6 1.0 1.4 -1.2 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 2.8 1.7 1.0
Whole body water mass 0.1 0.7 1.2 -1.1 -0.4
Leg predicted mass (right) 0.2 1.0 1.8 -1.3 -0.6
Arm fat mass (left) 0.3 1.2 1.9 0.7 1.4
Number of self-reported non-cancer illnesses 5.1 8.8 9.5 -2.9 -3.1
Average weekly champagne plus white wine intake 0.5 0.7 1.3 -0.4 -1.1
Miserableness 0.2 0.3 0.7 0.8 0.1
Guilty feelings 0.1 0.2 0.3 0.4 -0.5
Wears glasses or contact lenses 0.4 0.5 0.8 -0.9 -0.4
Ever taken oral contraceptive pill 3.1 3.5 4.9 -1.4 -2.2
Hearing aid user 0.1 0.1 0.2 0.4 0.4
Mother’s age at death 0.2 0.2 0.3 0.6 0.4
Financial situation satisfaction 0.1 0.1 0.2 -0.2 -0.5
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.6 -0.7 -0.7
Commuting to job workplace: Public transport 0.9 1.1 1.3 1.1 0.9
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 0.2 0.4
Medication: Blood pressure 0.1 0.2 0.3 0.2 -0.6
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 -0.2 -0.6
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.9 0.9 0.4
High cholesterol (Self-reported) 0.3 0.6 1.0 -0.5 -1.0
Medication: Bendroflumethiazide 0.4 0.6 1.1 1.0 -0.3
Medication: Paracetamol 0.0 0.0 0.1 -0.0 0.3
Medication: Lisinopril 1.2 1.5 2.9 1.7 0.4
Medication: Atorvastatin 0.5 0.6 0.6 -0.8 0.8
Illnesses of father: High blood pressure 0.3 0.4 0.4 -0.5 -0.7
Alcohol drinker status: Never 2.2 2.6 3.4 1.8 1.3
Ever smoked 1.8 3.2 4.3 -2.1 -1.4
Basal metabolic rate 0.1 0.6 1.2 -1.1 -0.3
Leg fat percentage (left) 0.3 0.9 1.6 0.5 1.3
Arm fat-free mass (left) 0.1 0.3 0.6 -0.8 -0.1
Number of operations (self-reported) 1.2 1.8 2.3 -1.5 -1.2
Average weekly beer plus cider intake 0.2 0.4 0.7 0.8 0.2
Irritability 1.1 1.9 2.5 -1.2 -1.6
Risk taking 1.1 1.6 2.1 -1.4 -1.0
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.1 0.2 0.2
Fractured/broken bones in last 5 years 0.9 1.2 1.9 -1.4 -0.7
Age started oral contraceptive pill 0.2 0.3 0.4 0.4 0.6
Diastolic blood pressure, automated reading 0.7 2.1 3.1 1.8 1.1
Ever depressed for a whole week 2.8 3.5 4.1 -2.0 -1.7
Unable to work because of sickness or disability 0.1 0.1 0.2 0.5 -0.2
Commuting to job workplace: Cycle 0.4 0.4 0.5 0.7 0.7
Myopia 0.2 0.3 0.4 0.3 0.7
Vascular/heart problems diagnosed by doctor 0.6 1.7 3.3 -0.1 1.8
Cholesterol lowering medication 0.1 0.1 0.2 -0.4 -0.1
Medication: Omeprazole (e.g. Zanprol) 2.2 2.6 3.0 -1.7 -1.5
Pain experienced in last month 0.6 1.1 1.5 0.8 1.2
Supplements: Calcium 0.8 0.9 1.5 -0.6 -1.2
Basal cell carcinoma (self-reported) 0.9 1.1 1.3 1.1 1.0
Heart attack/myocardial infarction (self-reported) 2.2 2.8 3.0 -1.6 -1.7
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.0 -0.0 0.0
Heart disease (siblings) 1.5 1.8 1.9 1.4 1.3
Alcohol drinker status: Previous 0.4 0.4 0.5 0.6 0.7
Pack years of smoking 0.3 0.4 0.4 -0.7 0.6
Impedance of whole body 1.2 6.2 9.2 -1.8 -3.0
Leg fat mass (left) 0.1 0.3 0.5 -0.2 0.7
Arm predicted mass (left) 0.1 0.5 1.0 -1.0 -0.3