Hub : Genes

RP11-45P15.4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.374	0.116	2.0e-03	0.174	NA	0.111	NA	0.139	1.1e-05	NA	4.3e-04	NA	8.8e-05
2	GTEx	Brain Nucleus accumbens basal ganglia	0.335	0.083	2.6e-05	0.071	NA	0.243	NA	0.202	5.8e-03	NA	3.7e-07	NA	4.2e-06
3	GTEx	Cells Transformed fibroblasts	0.177	0.066	5.8e-03	0.016	NA	0.077	NA	0.081	2.0e-02	NA	2.1e-06	NA	1.2e-06
4	GTEx	Skin Sun Exposed Lower leg	0.103	0.044	5.7e-03	0.037	NA	0.072	NA	0.056	5.0e-04	NA	1.5e-06	NA	2.0e-05
5	GTEx	Thyroid	0.088	0.040	7.1e-03	0.085	NA	0.053	NA	0.076	4.8e-07	NA	6.9e-05	NA	1.8e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.7	1.1	2.2	0.3	0.3	-1.5	-1.1	-1.4
Bipolar Disorder or Schizophrenia	3.3	7.9	16.8	-0.3	0.3	-3.2	-3.5	-4.1
Depressed Affect (Nagel 2018)	0.3	0.7	2.3	-0.5	0.6	-0.6	-0.0	-1.5
Depression (Nagel 2018)	0.4	0.5	1.2	-1.1	-0.9	0.2	0.6	-0.6
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.5	-0.0	1.6	0.6	-0.6	-0.7
Neuroticism (Nagel 2018)	0.4	0.8	2.6	-0.9	0.1	-0.8	0.4	-1.6
Schizophrenia (2018)	3.8	8.0	17.2	-0.7	0.1	-3.0	-3.6	-4.1
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	-1.0	-0.1	1.0	-0.1	0.3
Worry (Nagel 2018)	1.0	2.1	4.4	-1.3	-0.3	-2.1	-0.5	-2.1
Alzheimer’s Disease (in mother)	0.4	0.4	1.0	-1.0	-0.9	0.3	-0.5	0.4
Alzheimer’s Disease (in father)	0.7	0.7	2.5	-0.5	-1.6	0.5	-0.7	-0.0
Alzheimer’s Disease (including proxy)	1.0	1.4	3.2	-1.2	-1.8	0.3	-1.5	-0.1
Crohns Disease (2017)	0.9	2.0	3.6	-1.5	-1.9	-1.7	-0.9	-0.5
Irritable Bowel Disease (IBD)	1.3	3.1	5.5	-1.9	-1.6	-2.4	-1.6	-1.2
Ulcerative Colitis (UC)	1.2	2.2	3.6	-1.5	-0.8	-1.9	-1.6	-1.3
Major Depression (MDD)	1.0	1.2	4.2	0.4	1.3	-0.1	0.1	-2.0
Reaction Time	0.7	1.2	2.0	-1.4	-0.3	-1.3	-1.4	-0.9
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.8	0.3	2.0	0.2	-0.6	-1.3
Breast Cancer	1.0	2.4	4.2	-1.4	-1.5	-1.2	-1.5	-2.0
Ovarian Cancer	0.4	0.6	1.0	-0.5	-1.0	0.7	0.5	1.0
Prostate Cancer	0.8	1.2	4.2	2.0	-0.0	1.1	0.6	-0.2
Age at First Birth	0.9	1.3	2.8	-0.7	-1.1	0.5	1.4	1.7
Bipolar Disorder (2011)	3.0	2.9	5.1	-1.1	-0.4	-2.1	-1.9	-2.3
Body Mass Index (BMI) (2010)	1.2	1.6	2.1	-1.1	-1.4	-1.0	-1.4	-1.3
Coronary Artery Disease (CAD)	2.3	2.7	8.4	0.5	-0.5	2.9	1.4	1.7
Crohns Disease (2012)	0.2	0.3	0.7	0.0	-0.6	0.2	0.7	0.8
Mean Putamen Volume	1.6	1.8	5.8	-0.1	0.9	2.4	1.1	1.1
Fasting Glucose	0.6	0.7	2.5	-0.6	0.1	-1.6	0.0	-0.9
HbA1C	1.3	1.5	3.9	1.8	2.0	0.5	-0.1	0.3
HDL Cholesterol	0.3	0.4	1.6	0.4	0.1	-0.6	-1.3	0.1
LDL Cholesterol	0.6	0.9	2.1	1.2	1.4	0.2	1.0	0.1
Lupus	0.5	0.8	2.5	-0.4	-0.1	-1.6	-0.9	-0.6
Neuroticism (2016)	1.8	2.6	6.6	0.9	2.0	0.4	-1.2	-2.6
Primary Biliary Cirrhosis	0.6	0.8	1.2	-1.0	-0.3	-1.1	-0.9	-1.1
Rheumatoid Arthritis	0.1	0.1	0.4	-0.2	0.7	-0.4	0.0	-0.1
Schizophrenia (2014)	4.7	10.4	21.9	-1.9	-0.2	-3.2	-4.0	-4.7
Triglycerides	0.6	1.1	1.9	1.3	1.4	-0.4	1.2	0.6
Type 2 Diabetes (T2D) (2012)	3.4	3.9	5.4	-2.1	-1.2	-2.2	-2.3	-1.9
Ulcerative Colitis	0.9	1.3	2.1	-1.4	-0.9	-1.3	-0.9	-1.1
Blood Eosinophil Count	2.8	21.3	42.7	2.1	2.6	-5.7	-6.5	-4.5
Blood Platelet Count	0.5	6.2	16.3	-1.7	-4.0	-0.2	2.0	2.8
Blood Red Count	1.5	14.2	24.2	-0.8	-0.3	-4.9	-4.7	-4.9
Blood White Count	1.8	13.3	26.6	0.8	2.7	-3.1	-4.8	-5.2
Heel T-Score	5.7	45.2	125.4	-5.9	-11.2	-5.3	-5.7	-2.3
BMI	0.5	2.8	11.4	-1.5	-3.4	0.3	-0.4	0.6
Height	0.3	6.5	15.5	0.2	2.5	0.8	3.9	3.1
Waist Hip Ratio (WHR)	0.1	0.2	0.9	-0.4	-0.9	0.2	0.3	-0.2
Systolic Blood Pressure	0.5	2.4	6.4	1.0	-0.3	1.1	-1.8	-2.5
Smoking Status	0.9	2.2	5.3	1.3	0.4	-0.9	-2.3	-1.8
Allergy or Eczema	0.1	0.3	1.0	0.3	-0.1	-0.7	1.0	0.4
Cardiovascular Disease	1.5	5.1	12.8	-1.4	-1.9	-0.9	-3.6	-2.6
Hypothyroidism (self reported)	0.4	1.0	2.6	-0.2	1.0	-1.1	-0.3	-1.6
Respiratory disease	0.6	1.3	2.4	-0.8	-1.6	-1.4	-0.4	-1.3
Type 2 Diabetes (T2D) (2018)	2.1	3.9	8.2	-2.9	-2.8	-1.4	-0.9	-0.8
Lung FEV1/FVC ratio	0.3	1.8	4.5	0.8	1.7	0.6	0.4	2.1
Lung FVC	0.6	3.0	7.2	1.6	0.9	1.4	1.6	2.7
Neuroticism	0.3	0.7	1.6	-1.0	-0.3	-0.9	0.2	-1.3
Chronotype (morning person)	0.2	0.5	1.4	-1.2	0.2	-0.1	0.9	0.1
Hair Pigment	0.2	5.1	8.8	-1.5	-3.0	-1.2	-2.5	-2.6
Tanning	0.2	1.8	7.0	0.9	0.8	2.6	-0.3	0.9
Hand grip strength (left)	0.7	1.8	4.5	-2.1	-1.2	0.0	1.6	0.8
Number of treatments/medications taken	0.4	0.7	2.1	1.4	-0.3	1.1	0.0	-0.5
Average weekly spirits intake	0.8	1.0	4.3	-0.7	-2.1	-0.1	0.3	0.5
Sensitivity / hurt feelings	0.6	1.1	3.5	0.2	1.1	-0.8	-0.2	-1.9
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.6	-1.6	-1.4	0.6	1.6	0.2
Hearing difficulty/problems: Yes	0.2	0.3	0.5	0.5	-0.5	-0.7	-0.3	-0.4
Relative age of first facial hair	1.7	3.5	6.6	-1.7	-1.5	-1.5	-2.6	-1.8
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	1.9	1.2	0.9	-0.1	-1.1	-1.4
Ever used hormone-replacement therapy (HRT)	1.3	1.7	4.9	2.2	-0.0	1.3	-0.0	1.3
Ever had hysterectomy (womb removed)	0.2	0.3	0.9	0.2	-0.6	-0.3	0.9	0.1
Systolic blood pressure, automated reading	0.5	1.5	5.4	1.1	-0.8	2.3	0.1	-0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.3	0.1	0.4	0.3	-0.4
Angina	4.1	5.4	7.2	-2.1	-2.2	-2.1	-2.7	-2.6
Medication for hormone replacement therapy	2.2	2.4	5.2	1.0	0.7	2.3	1.6	1.7
Vitamin and mineral supplements	3.1	4.2	9.8	-3.1	-3.1	-1.2	-0.0	0.4
Supplements: Zinc	2.2	2.4	4.1	2.0	1.9	-0.5	-1.4	-1.4
Medication: Co-codamol	0.8	0.9	2.6	1.6	0.9	-0.0	0.1	-1.0
Medication: Metformin	1.0	1.5	5.1	-1.3	-2.3	-0.8	-0.0	0.2
Diabetes (father)	0.1	0.1	0.2	0.2	0.2	0.4	0.4	0.4
Diabetes (mother)	0.5	0.6	1.4	-0.2	0.3	-1.2	-1.2	-0.5
Severe depression (siblings)	1.3	1.4	4.9	-1.1	-0.5	-0.9	-0.2	-2.2
Pack years adult smoking proportion	2.0	3.0	7.5	-2.6	-2.7	-0.8	-0.1	-0.3
Impedance of leg (right)	0.7	3.2	10.1	1.6	3.2	-0.5	-0.1	-1.7
Leg fat-free mass (left)	0.3	1.4	3.1	-0.5	-1.3	0.7	1.1	1.8
Trunk fat percentage	0.3	1.0	4.1	-0.8	-2.0	0.1	0.4	-0.0
Hand grip strength (right)	1.2	3.4	5.0	-2.1	-1.7	1.1	2.2	1.8
Townsend deprivation index at recruitment	0.5	0.7	1.7	0.1	-0.8	0.2	-1.3	-1.1
Current tobacco smoking	0.1	0.2	0.5	0.4	-0.7	0.3	-0.5	0.0
Average weekly fortified wine intake	0.2	0.2	0.5	0.5	0.7	-0.5	-0.1	-0.0
Maternal smoking around birth	1.1	1.5	3.5	-0.4	-1.9	-0.2	-1.1	-1.6
Fed-up feelings	0.7	1.2	2.9	-1.3	0.1	-0.1	1.1	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.4	-0.0	0.1	0.6	1.1	-1.2
Relative age voice broke	2.4	3.6	6.7	-1.6	-0.6	-2.6	-2.2	-1.9
Taking other prescription medications	0.7	1.1	3.6	-0.0	-0.7	-1.0	0.3	-1.9
Age when periods started (menarche)	1.6	4.0	9.0	0.7	0.8	-2.2	-2.2	-3.0
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.6	0.3	-0.0	0.1	0.8	0.1
Heel bone mineral density (BMD) T-score, automated (left)	4.6	10.5	24.7	-3.9	-5.0	-1.8	-2.6	-1.5
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.7	0.9	-0.3	0.3	1.3	0.0
Qualifications: CSEs or equivalent	0.1	0.2	0.7	0.3	0.3	0.1	-0.1	0.8
Serious illness, injury or assault to yourself	1.7	2.1	4.3	-1.7	-0.7	-2.1	-0.8	-1.5
High blood pressure	1.5	4.1	10.0	-0.9	-1.3	-0.9	-3.2	-2.6
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.1	0.7	0.2	-0.1	1.8	0.5
Multivitamins +/- minerals	2.4	3.1	7.3	2.7	2.5	1.1	0.0	-0.9
Stomach or abdominal pain in last month	1.2	1.5	3.6	0.4	0.1	1.9	1.8	0.4
Supplements: Glucosamine	3.6	4.7	8.8	2.0	1.0	2.2	2.2	3.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.1	1.0	0.2	0.4	0.0	0.3
Medication: Atenolol	0.2	0.2	0.4	0.2	-0.5	0.1	0.6	-0.5
Medication: Levothyroxine sodium	0.3	0.6	2.0	-0.4	0.2	0.2	0.7	-1.4
Sitting height	0.1	0.4	1.0	0.4	1.0	-0.7	-0.3	0.3
Chronic bronchitis/emphysema (father)	0.8	1.0	3.8	1.9	0.3	0.3	-0.9	-0.0
High blood pressure (mother)	0.3	0.4	1.1	-0.3	-0.7	0.5	0.2	-1.1
Body mass index (BMI)	0.6	2.5	7.9	-1.8	-2.8	-0.5	-0.9	-0.5
Impedance of leg (left)	0.6	2.8	8.3	1.8	2.9	-0.4	0.0	-1.4
Leg predicted mass (left)	0.2	1.2	2.9	-0.4	-1.2	0.6	1.1	1.7
Trunk fat mass	0.3	1.3	4.8	-1.1	-2.2	0.0	0.7	0.3
Waist circumference	0.3	1.1	4.1	-0.9	-2.0	0.5	0.4	0.4
Number of incorrect matches in round	1.5	2.5	5.6	-2.3	-2.4	-0.5	-1.0	-0.1
Past tobacco smoking	0.6	1.2	2.2	-1.1	-0.6	0.9	1.5	1.1
Alcohol usually taken with meals	0.7	1.1	3.1	-1.8	0.2	-1.4	0.4	0.0
Nervous feelings	0.4	0.8	1.8	-1.0	-0.6	-0.6	1.3	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.4	-0.8	-0.4	0.4	1.6	-0.5
Hearing difficulty/problems with background noise	0.8	1.2	3.5	0.2	-1.9	-1.4	-0.2	-0.9
Hair/balding pattern: Pattern 2	0.6	0.7	1.9	-0.8	-1.4	-0.7	0.5	0.5
Had menopause	1.2	1.5	3.6	0.7	-1.0	1.6	0.4	1.9
Had other major operations	1.0	1.2	2.4	-1.0	-0.0	-1.3	-0.9	-1.6
Forced vital capacity (FVC)	0.6	2.3	5.8	1.2	2.4	0.4	1.6	1.2
Heel bone mineral density (BMD) T-score, automated (right)	3.5	8.1	19.1	-3.1	-4.4	-1.6	-2.6	-1.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.8	-0.5	-0.3	-0.9	0.1	-1.3
Qualifications: None of the above	0.1	0.3	1.1	0.5	-1.0	0.5	0.1	0.2
Financial difficulties in last 2 years	0.5	0.7	2.7	0.2	0.4	-0.6	-0.3	-1.6
Mouth/teeth dental problems	1.2	1.8	4.3	1.5	2.1	0.4	0.6	1.4
Heart attack	0.8	1.0	1.8	-0.6	-1.3	-0.8	-1.3	-0.7
Allergy	0.3	0.7	2.1	-0.2	0.8	1.4	-0.4	0.8
Pain all over the body in last month	0.8	0.9	1.8	0.9	-0.2	0.3	-1.3	-1.4
Diabetes (self-reported)	2.4	3.8	6.8	-2.6	-2.4	-2.0	-0.9	-1.3
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.8	1.7	0.3	1.7	1.5	0.9
Medication: Ramipril	1.6	2.0	3.0	-0.8	-1.6	-1.0	-1.7	-1.7
Medication: Simvastatin	0.5	0.7	2.2	-0.8	-1.5	0.4	-0.2	0.7
Fluid intelligence score	0.4	0.9	2.4	-0.6	0.9	-0.6	-0.7	-1.5
Illnesses of siblings	0.7	1.0	2.3	0.5	1.5	-1.1	0.8	0.6
Neuroticism score	0.6	1.2	4.2	-1.1	0.3	-0.7	0.2	-2.1
Weight	0.3	1.2	3.2	-1.1	-1.8	0.2	0.7	1.0
Impedance of arm (right)	0.5	2.5	4.6	1.8	2.0	0.8	2.1	0.6
Arm fat percentage (right)	0.3	1.2	4.7	-1.1	-2.2	-0.2	-0.2	-0.3
Trunk fat-free mass	0.2	1.0	2.5	-0.6	-0.6	0.5	1.3	1.6
Hip circumference	0.1	0.6	1.5	-0.9	-1.2	0.1	0.6	0.3
Time employed in main current job	0.6	0.7	2.5	-0.8	-1.6	-0.3	0.5	-0.1
Alcohol intake versus 10 years previously	0.7	1.1	2.7	-1.0	-0.8	-0.7	-0.8	-1.6
Father’s age at death	0.6	0.8	3.0	-1.7	-0.5	-0.8	-0.5	-0.0
Worrier / anxious feelings	0.2	0.4	1.4	-0.3	0.0	-0.4	-0.5	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.4	-0.4	-1.5	0.5	1.0	-1.6
Falls in the last year	0.3	0.4	1.5	0.6	0.3	-0.5	0.2	-1.2
Hair/balding pattern: Pattern 3	0.6	0.9	2.2	-0.5	0.3	-0.5	-1.5	-1.2
Number of live births	0.9	1.3	4.1	0.4	0.4	-0.9	-1.1	-2.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	5.4	0.7	2.3	0.4	1.6	1.6
Pulse rate	1.1	1.9	4.0	2.0	0.0	2.0	-0.1	1.2
Happiness	1.0	1.2	5.0	0.6	0.8	-0.1	2.2	0.1
Noisy workplace	0.2	0.3	1.0	0.2	-1.0	-0.0	-0.1	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.8	0.1	1.7	0.2	0.1	-1.5
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	2.6	1.6	1.6	0.7	0.9	0.7
Mouth/teeth dental problems: Dentures	0.9	1.5	5.6	-1.0	-2.4	-0.3	-0.8	-0.5
Asthma	0.7	1.4	3.3	-0.6	-1.8	-1.1	-0.3	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.5	-1.2	-0.9	-0.8	-0.8	-1.2
Medication: Cholesterol lowering	1.6	2.5	3.8	-1.6	-1.4	-1.4	-1.9	-1.5
Depression (self-reported)	0.3	0.3	1.0	-0.3	1.0	-0.1	0.1	-0.7
Medication: Lansoprazole	0.7	0.8	2.9	-0.7	-0.8	-0.1	1.7	0.5
Prospective memory result	0.5	0.6	1.6	-1.0	-1.3	-0.0	-0.6	-0.1
Lung cancer (father)	4.1	4.8	11.5	-0.8	0.1	-3.4	-2.4	-2.5
Illnesses of mother	0.4	0.5	1.4	0.1	1.2	-0.7	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	5.6	0.5	1.7	0.1	2.4	1.9
Pulse wave Arterial Stiffness index	0.6	0.7	2.2	0.5	0.4	-1.5	-0.5	-0.8
Impedance of arm (left)	0.4	1.6	2.6	1.3	1.6	1.0	1.6	0.6
Arm fat mass (right)	0.3	1.2	4.7	-1.1	-2.2	0.1	0.2	0.2
Trunk predicted mass	0.2	1.0	2.4	-0.6	-0.6	0.6	1.2	1.6
Standing height	0.6	5.6	11.6	1.2	2.0	1.5	3.4	2.9
Length of working week for main job	0.9	1.0	3.0	1.7	0.7	0.3	-1.1	-0.3
Exposure to tobacco smoke at home	3.5	3.9	8.3	-2.3	-0.9	-2.0	-1.1	-2.9
Breastfed as a baby	1.0	1.2	3.0	1.2	1.7	-0.8	-1.0	0.3
Tense / ‘highly strung’	2.1	3.5	8.7	-0.6	1.5	-2.1	-1.3	-3.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	7.1	1.1	2.1	-1.5	-0.7	-2.7
Hair/balding pattern: Pattern 4	0.8	1.8	3.0	1.1	0.7	-1.7	-1.6	-1.3
Birth weight of first child	0.1	0.1	0.4	-0.3	-0.1	-0.2	0.7	0.3
Peak expiratory flow (PEF)	0.1	0.2	0.5	-0.2	-0.3	0.0	0.7	0.5
Pulse wave reflection index	2.2	2.7	8.4	-0.7	0.4	-2.9	-1.6	-1.4
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.7	-1.1	-1.2	1.0	0.9	-1.6
Loud music exposure frequency	0.6	0.7	1.7	1.3	1.1	0.2	-0.4	-0.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	5.7	0.7	2.4	0.3	0.1	-0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	-0.6	-0.3	0.3	-0.2	-0.8
Blood clot in the leg (DVT)	0.2	0.2	0.6	-0.2	-0.8	-0.0	0.4	0.7
Medication: Paracetamol	0.3	0.4	1.4	-0.3	-1.2	0.4	-0.6	-0.4
Headache pain in last month	0.2	0.4	1.0	0.2	0.6	0.3	1.0	-0.6
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	3.7	0.9	1.2	1.1	1.9	1.6
Glaucoma (self-reported)	1.0	1.2	2.9	0.8	1.7	0.5	1.2	0.9
Gout (self-reported)	0.8	1.1	2.1	-0.8	-1.4	-0.6	-1.1	-1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.6	-0.3	0.2	-0.4	0.2	-1.6
Medication: Amlodipine	1.0	1.3	3.7	-0.1	-0.4	-1.1	-1.9	-1.3
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.9	2.0	0.6	0.5	0.1	-0.5
Birth weight	2.0	4.4	8.5	1.4	1.6	0.9	2.9	2.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.8	0.1	-0.7	-0.3	0.2	-1.3
High blood pressure (siblings)	1.4	2.0	4.0	-1.0	-2.0	0.5	-1.6	-1.6
Forced vital capacity (FVC), Best measure	0.7	2.5	4.7	1.1	2.1	0.1	2.2	1.5
Body fat percentage	0.3	1.2	4.8	-0.9	-2.2	-0.2	-0.1	-0.4
Leg fat percentage (right)	0.4	1.3	2.2	-1.1	-1.5	-0.9	-0.9	-1.3
Arm fat-free mass (right)	0.1	0.8	1.3	-1.0	-1.1	0.1	0.5	1.1
Exposure to tobacco smoke outside home	0.4	0.6	1.1	0.3	0.6	-0.7	-1.0	-1.0
Comparative body size at age 10	0.5	1.5	4.5	-0.9	-0.4	-0.8	2.1	1.1
Number of full brothers	0.5	0.6	1.5	-0.1	-0.6	-0.2	-1.0	-1.2
Worry too long after embarrassment	0.5	0.8	1.8	-1.3	-1.1	-0.4	-0.5	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	4.2	-0.1	0.0	-0.5	1.9	-2.1
Wheeze or whistling in the chest in last year	1.7	3.0	11.3	-1.8	-3.4	-0.1	0.1	-0.8
Number of children fathered	0.6	0.7	2.0	-1.4	-1.1	0.3	-0.1	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	0.2	-0.1	1.0	1.3	0.4
Age at first live birth	0.6	1.1	3.3	0.5	0.3	1.3	0.2	1.8
Pulse wave peak to peak time	0.8	0.9	2.7	-0.5	-0.3	1.6	0.7	1.0
Health satisfaction	2.9	3.7	5.9	-2.3	-2.0	-1.9	-0.3	-2.4
Shortness of breath walking on level ground	0.4	0.5	2.0	0.2	-0.7	0.1	1.4	-0.1
Qualifications: College or University degree	0.3	0.8	2.5	-1.6	0.7	-0.8	0.4	-0.4
Eye problems/disorders: None of the above	0.4	0.4	1.0	-0.3	-1.0	0.8	-0.1	0.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.0	1.4	1.1	0.1	-1.3	-1.2
Emphysema/chronic bronchitis	1.1	1.2	2.3	0.0	-0.7	-1.5	-1.5	-1.1
Medication for pain relief, constipation, heartburn	0.5	0.9	1.9	-0.3	1.1	-1.4	-1.2	0.3
Neck or shoulder pain in last month	0.2	0.3	1.0	0.2	0.4	-0.7	0.1	-1.0
Medication: Blood pressure	0.9	1.5	4.4	0.1	-0.7	-0.7	-1.4	-2.1
Angina (self-reported)	4.3	5.7	6.8	-2.2	-2.3	-2.1	-2.6	-2.5
Migraine (self-reported)	2.0	2.5	3.5	-1.8	-1.2	1.4	1.9	1.5
Medication: Ibuprofen	0.9	1.1	1.7	-1.3	-0.9	-1.0	-0.5	-1.2
Medication: Allopurinol	0.7	1.0	2.6	-0.7	-0.4	-0.7	-1.6	-1.0
Medication: Omeprazole	0.1	0.1	0.3	-0.5	0.1	0.4	0.3	-0.3
Medication: Seretide 50 evohaler	0.6	0.7	1.2	1.1	0.1	0.8	1.0	0.6
Mean time to correctly identify matches	0.3	0.7	1.1	-1.0	-0.8	-0.8	-0.9	-0.4
Heart disease (mother)	1.1	1.4	3.6	-1.0	-1.2	-1.9	-0.5	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.2	0.1	-0.5	1.4	1.5	1.1
Whole body fat mass	0.2	1.0	4.3	-0.9	-2.1	-0.2	0.1	0.0
Leg fat mass (right)	0.3	1.1	3.3	-1.1	-1.8	-0.7	-0.3	-0.6
Arm predicted mass (right)	0.2	0.8	1.3	-1.0	-1.1	0.4	0.5	1.2
Pulse rate, automated reading	0.4	1.2	2.7	1.6	0.1	1.6	0.0	0.7
Alcohol intake frequency.	0.3	0.7	1.4	1.2	0.9	-0.0	1.1	0.0
Comparative height size at age 10	1.1	6.1	13.0	1.3	1.7	2.3	2.8	3.6
Number of full sisters	0.4	0.5	1.4	0.3	-0.9	-0.2	-0.3	-1.2
Suffer from ‘nerves’	0.2	0.4	1.2	-0.6	0.3	0.2	1.1	-0.5
Overall health rating	0.6	1.2	5.2	-0.2	-2.3	0.2	0.6	-0.6
Chest pain or discomfort	3.6	5.1	10.3	-1.9	-3.2	-0.8	-1.3	-3.0
Had major operations	0.3	0.3	0.8	0.9	0.5	-0.5	-0.5	0.3
Age at last live birth	0.4	0.6	2.0	0.1	0.6	-0.1	-1.4	-0.7
Family relationship satisfaction	0.4	0.5	1.4	-0.7	0.1	0.3	1.2	-0.7
Leg pain on walking	0.6	0.7	1.9	-0.4	-1.4	-0.6	0.8	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	4.2	-0.7	-0.4	-1.5	-2.1	-1.9
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	0.6	0.8	0.2	0.0	0.5
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.0	1.1	1.0	1.0	-0.1	1.4
Medication: Aspirin	0.4	0.6	2.3	-0.1	-0.5	0.6	1.5	-0.1
Supplements: Vitamin C	1.5	1.8	5.0	1.8	2.2	0.4	0.1	-0.6
Knee pain experienced in last month	1.2	1.8	4.5	-0.1	-0.6	2.1	1.3	1.6
Hypertension (Self-reported)	0.9	2.6	7.4	-0.5	-1.1	-0.5	-2.7	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.4	-0.6	-0.6	1.5	1.5	-0.1
Illnesses of father: Heart disease	1.7	2.4	3.7	1.6	0.6	1.9	1.9	1.3
Illnesses of siblings: Diabetes	0.8	1.0	2.9	-0.8	-0.5	-1.7	-1.2	-0.1
Smoking status: Previous	1.1	1.6	2.0	1.4	1.0	-1.1	-1.4	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.6	0.5	1.7	0.7	2.1	0.8
Whole body fat-free mass	0.2	1.3	3.2	-0.5	-0.9	0.7	1.3	1.8
Leg fat-free mass (right)	0.3	1.6	4.0	-0.3	-1.3	0.8	1.3	2.0
Arm fat percentage (left)	0.3	1.3	5.2	-1.2	-2.3	0.0	-0.2	-0.1
Average weekly red wine intake	0.3	0.4	1.4	0.5	0.7	0.0	-0.1	1.2
Handedness (chirality/laterality): Left-handed	1.6	1.9	6.1	2.5	0.7	1.7	0.3	0.6
Mood swings	0.8	1.5	3.6	0.6	1.9	-0.4	0.2	-1.8
Loneliness, isolation	0.5	0.6	1.6	-1.0	-1.3	-0.3	0.1	-0.7
Long-standing illness, disability or infirmity	0.3	0.5	2.0	-0.2	-0.4	0.2	0.6	-1.4
Ever had bowel cancer screening	0.6	0.7	1.3	0.9	0.6	0.2	1.0	1.1
Diabetes diagnosed by doctor	1.7	2.9	5.7	-2.4	-2.3	-1.4	-0.5	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.4	-0.5	-1.2	1.1	-0.2	-0.7
Friendships satisfaction	0.5	0.6	1.5	-0.9	0.6	-0.6	0.0	-1.2
Qualifications: nursing, teaching	0.3	0.4	1.8	0.4	1.3	-0.4	0.2	-0.2
Commuting to job workplace: Walk	0.8	0.9	3.1	-0.6	0.1	-0.8	0.2	-1.8
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.4	0.2	-0.2	-0.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	-0.3	0.6	-0.2	0.0	-0.6
Medication for cholesterol	0.7	1.0	3.6	-0.6	0.6	-1.9	0.3	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.0	1.2	0.5	1.1	1.4	1.3
Back pain experienced in last month	0.4	0.6	1.2	0.8	0.6	0.3	1.1	-0.7
Mineral and other dietary supplements	1.7	2.3	4.9	-2.2	-2.2	-1.2	0.6	-0.5
Breast cancer (self-reported)	0.8	1.0	2.1	0.7	1.4	0.4	-0.5	1.4
Asthma (self-reported)	0.8	1.5	3.0	-0.6	-1.7	-1.2	-0.3	-1.6
Osteoporosis (self-reported)	2.9	3.5	6.7	2.6	2.5	0.8	2.0	0.4
Osteoarthritis (self-reported)	0.9	1.2	2.5	0.5	0.4	-1.6	-1.3	-1.2
Medication: Aspirin	0.5	0.6	2.4	-0.2	-0.4	0.6	1.5	-0.3
Medication: Gliclazide	0.7	0.8	2.4	-1.0	-0.2	-0.2	-0.5	-1.6
Illnesses of father: None of the above (group 1)	4.3	5.3	9.8	-2.0	1.5	-3.1	-2.7	-1.9
Smoking status: Current	0.2	0.3	1.0	-0.2	-1.0	-0.0	-0.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.0	1.3	0.5	0.5	1.3	1.4
Whole body water mass	0.2	1.2	3.4	-0.5	-0.7	0.6	1.2	1.8
Leg predicted mass (right)	0.3	1.5	3.7	-0.3	-1.3	0.8	1.2	1.9
Arm fat mass (left)	0.3	1.2	4.5	-1.2	-2.1	0.2	0.2	0.3
Number of self-reported non-cancer illnesses	3.1	5.4	14.4	-0.6	-1.0	-2.5	-2.2	-3.8
Average weekly champagne plus white wine intake	0.3	0.4	0.9	-0.5	0.1	-0.8	0.9	0.6
Miserableness	0.4	0.7	2.3	-0.3	0.8	-0.6	0.1	-1.5
Guilty feelings	0.5	0.8	3.3	-0.8	-0.3	0.1	1.8	-0.1
Wears glasses or contact lenses	0.5	0.6	1.5	0.3	-0.1	-0.3	1.2	1.1
Ever taken oral contraceptive pill	0.3	0.3	1.2	0.6	-0.2	0.2	-1.1	-0.0
Hearing aid user	0.2	0.3	0.7	0.4	0.8	-0.6	-0.3	-0.2
Mother’s age at death	1.0	1.3	1.8	1.3	1.3	0.9	1.1	0.8
Financial situation satisfaction	0.7	0.8	2.1	1.4	0.9	-0.1	-0.2	-1.0
Tinnitus: Yes, now most or all of the time	2.0	2.3	5.6	2.4	1.6	-1.4	-1.2	-0.3
Commuting to job workplace: Public transport	0.5	0.6	1.4	-0.7	-1.2	0.7	0.4	0.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.8	-0.1	0.3	-0.1	0.9	0.7
Medication: Blood pressure	0.7	1.4	5.5	-0.0	-1.0	0.1	-2.3	-0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	0.4	-0.4	0.9	-1.0	-0.6
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.5	1.9	2.1	0.5	0.3	0.2
High cholesterol (Self-reported)	0.3	0.5	0.9	-0.8	-1.0	-0.2	-0.6	-0.9
Medication: Bendroflumethiazide	1.2	1.8	5.6	-0.8	-0.6	-1.0	-2.4	-1.2
Medication: Paracetamol	0.2	0.3	0.9	-0.0	-1.0	0.3	-0.5	0.3
Medication: Lisinopril	3.6	4.7	10.6	0.4	1.3	-1.7	-3.3	-2.9
Medication: Atorvastatin	1.0	1.3	2.8	-0.8	-0.3	-0.8	-1.5	-1.7
Illnesses of father: High blood pressure	1.7	2.1	9.1	-0.4	-3.0	0.9	0.7	-0.0
Alcohol drinker status: Never	1.7	2.0	4.6	1.2	0.5	0.6	2.1	1.8
Ever smoked	0.2	0.4	0.9	0.9	0.7	0.4	-0.4	0.3
Basal metabolic rate	0.2	1.1	2.5	-0.6	-1.0	0.6	1.2	1.6
Leg fat percentage (left)	0.4	1.4	3.2	-1.1	-1.8	-0.9	-0.8	-1.1
Arm fat-free mass (left)	0.1	0.4	1.1	-0.6	-0.6	0.2	0.5	1.0
Number of operations (self-reported)	0.5	0.8	2.2	-0.5	-0.2	-0.8	-1.5	-0.9
Average weekly beer plus cider intake	0.5	0.7	1.4	1.0	-0.4	0.4	-1.2	-0.8
Irritability	0.7	1.2	2.5	-0.0	1.6	0.7	1.3	-1.1
Risk taking	0.9	1.4	4.2	-1.0	-0.9	-0.6	-0.8	-2.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	-0.3	-1.0	-0.1	0.8	0.8
Fractured/broken bones in last 5 years	2.4	3.1	6.1	-0.3	-0.6	2.2	2.0	2.5
Age started oral contraceptive pill	0.2	0.3	0.9	0.9	0.2	0.1	0.3	0.7
Diastolic blood pressure, automated reading	0.4	1.2	2.7	1.4	-0.6	1.6	-0.8	0.3
Ever depressed for a whole week	0.8	1.0	2.2	-1.5	-1.1	-0.4	0.8	-0.7
Unable to work because of sickness or disability	0.3	0.3	1.3	0.2	-1.1	-0.4	0.4	0.0
Commuting to job workplace: Cycle	1.5	1.8	2.9	-1.6	-1.7	1.2	1.3	0.8
Myopia	0.8	1.1	2.6	-0.1	1.6	-1.5	-0.7	-0.7
Vascular/heart problems diagnosed by doctor	1.8	4.9	11.8	0.8	1.3	1.1	3.4	3.0
Cholesterol lowering medication	0.2	0.3	0.8	-0.0	-0.6	0.9	0.2	0.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	-0.6	0.0	0.7	0.8	-0.4
Pain experienced in last month	1.0	1.7	4.4	-1.2	-0.4	-1.5	-2.1	0.4
Supplements: Calcium	0.9	1.0	3.1	1.2	1.8	0.2	0.5	-0.4
Basal cell carcinoma (self-reported)	0.5	0.7	1.7	1.2	1.3	0.2	0.2	-0.2
Heart attack/myocardial infarction (self-reported)	0.8	1.1	1.9	-0.6	-1.2	-1.0	-1.4	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	0.1	-0.3	0.0	0.6	0.6
Heart disease (siblings)	0.4	0.5	2.0	0.2	-0.0	1.4	-0.4	-0.2
Alcohol drinker status: Previous	0.8	0.9	3.3	0.3	0.2	-0.2	-1.1	-1.8
Pack years of smoking	2.1	3.1	7.8	-2.6	-2.8	-1.0	-0.0	-0.2
Impedance of whole body	0.4	2.0	6.0	1.7	2.4	0.4	1.0	-0.4
Leg fat mass (left)	0.3	1.1	3.8	-1.1	-1.9	-0.7	-0.4	-0.5
Arm predicted mass (left)	0.1	0.6	1.6	-0.4	-0.7	0.4	0.7	1.3