Hub : Genes

RP11-473I1.10

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.316 0.0393 0 0.239 0.18 0.28 0.269 0.276 2.4e-30 1.4e-22 4.6e-36 1.5e-34 1.3e-35

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bipolar Disorder (2018) 0.1 0.1 0.1 0.4
Bipolar Disorder or Schizophrenia 0.0 0.1 0.1 0.3
Depressed Affect (Nagel 2018) 4.1 8.6 8.6 -2.9
Depression (Nagel 2018) 0.2 0.4 0.4 -0.6
Intelligence (Savage-Jansen 2018) 0.5 1.4 1.4 -1.2
Neuroticism (Nagel 2018) 1.6 3.8 3.8 -1.9
Schizophrenia (2018) 0.0 0.0 0.0 0.1
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 -0.0
Worry (Nagel 2018) 0.4 0.8 0.8 -0.9
Alzheimer’s Disease (in mother) 0.4 0.5 0.5 -0.7
Alzheimer’s Disease (in father) 0.0 0.0 0.0 -0.1
Alzheimer’s Disease (including proxy) 0.0 0.0 0.0 0.1
Crohns Disease (2017) 0.6 1.3 1.3 -1.1
Irritable Bowel Disease (IBD) 1.2 2.9 2.9 -1.7
Ulcerative Colitis (UC) 0.8 1.5 1.5 -1.2
Major Depression (MDD) 0.4 0.5 0.5 -0.7
Reaction Time 0.4 0.8 0.8 -0.9
Verbal and Numeric Reasoning (VNR) 0.9 2.1 2.1 -1.4
Breast Cancer 0.2 0.4 0.4 -0.6
Ovarian Cancer 0.2 0.3 0.3 -0.5
Prostate Cancer 0.4 0.6 0.6 0.8
Age at First Birth 4.5 6.6 6.6 2.6
Bipolar Disorder (2011) 0.5 0.5 0.5 -0.7
Body Mass Index (BMI) (2010) 6.0 8.2 8.2 -2.9
Coronary Artery Disease (CAD) 0.1 0.1 0.1 -0.3
Crohns Disease (2012) 0.2 0.3 0.3 -0.5
Mean Putamen Volume 0.1 0.1 0.1 -0.3
Fasting Glucose 0.0 0.0 0.0 -0.1
HbA1C 0.5 0.6 0.6 -0.8
HDL Cholesterol 1.3 2.2 2.2 1.5
LDL Cholesterol 1.8 2.8 2.8 -1.7
Lupus 0.2 0.4 0.4 -0.6
Neuroticism (2016) 1.1 1.6 1.6 -1.3
Primary Biliary Cirrhosis 1.3 1.8 1.8 -1.3
Rheumatoid Arthritis 0.2 0.3 0.3 0.6
Schizophrenia (2014) 0.0 0.0 0.0 0.1
Triglycerides 1.0 1.7 1.7 -1.3
Type 2 Diabetes (T2D) (2012) 0.4 0.5 0.5 0.7
Ulcerative Colitis 0.1 0.2 0.2 -0.4
Blood Eosinophil Count 0.1 0.5 0.5 -0.7
Blood Platelet Count 1.2 14.2 14.2 -3.8
Blood Red Count 0.5 4.9 4.9 2.2
Blood White Count 0.5 3.7 3.7 -1.9
Heel T-Score 2.3 18.3 18.3 4.3
BMI 4.4 25.3 25.3 -5.0
Height 1.5 28.7 28.7 -5.4
Waist Hip Ratio (WHR) 0.9 4.0 4.0 2.0
Systolic Blood Pressure 0.1 0.7 0.7 0.9
Smoking Status 2.4 5.7 5.7 -2.4
Allergy or Eczema 0.0 0.1 0.1 0.3
Cardiovascular Disease 0.0 0.0 0.0 -0.0
Hypothyroidism (self reported) 0.9 2.1 2.1 -1.5
Respiratory disease 0.0 0.0 0.0 0.1
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.1 -0.2
Lung FEV1/FVC ratio 0.1 0.3 0.3 -0.6
Lung FVC 1.4 6.9 6.9 2.6
Neuroticism 0.8 2.0 2.0 -1.4
Chronotype (morning person) 0.3 0.6 0.6 -0.8
Hair Pigment 0.0 0.3 0.3 -0.6
Tanning 0.0 0.3 0.3 -0.5
Hand grip strength (left) 0.5 1.3 1.3 1.1
Number of treatments/medications taken 2.9 5.3 5.3 -2.3
Average weekly spirits intake 1.6 2.0 2.0 -1.4
Sensitivity / hurt feelings 0.0 0.0 0.0 -0.1
Frequency of depressed mood in last 2 weeks 0.0 0.0 0.0 0.2
Hearing difficulty/problems: Yes 4.7 7.2 7.2 -2.7
Relative age of first facial hair 0.1 0.2 0.2 -0.5
Other serious medical condition/disability diagnosed by doctor 2.4 3.1 3.1 -1.8
Ever used hormone-replacement therapy (HRT) 1.6 2.0 2.0 -1.4
Ever had hysterectomy (womb removed) 0.0 0.0 0.0 -0.1
Systolic blood pressure, automated reading 0.1 0.3 0.3 -0.6
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.0 -0.0
Angina 1.4 1.8 1.8 -1.3
Medication for hormone replacement therapy 0.1 0.1 0.1 -0.4
Vitamin and mineral supplements 0.0 0.0 0.0 -0.1
Supplements: Zinc 0.5 0.6 0.6 0.8
Medication: Co-codamol 0.0 0.1 0.1 -0.2
Medication: Metformin 0.0 0.0 0.0 0.2
Diabetes (father) 0.1 0.1 0.1 -0.3
Diabetes (mother) 2.4 3.1 3.1 -1.8
Severe depression (siblings) 3.0 3.4 3.4 -1.8
Pack years adult smoking proportion 1.2 1.9 1.9 -1.4
Impedance of leg (right) 0.0 0.2 0.2 0.4
Leg fat-free mass (left) 3.1 16.3 16.3 -4.0
Trunk fat percentage 4.7 18.7 18.7 -4.3
Hand grip strength (right) 0.2 0.5 0.5 -0.7
Townsend deprivation index at recruitment 0.0 0.0 0.0 -0.1
Current tobacco smoking 0.1 0.1 0.1 0.4
Average weekly fortified wine intake 0.8 0.9 0.9 -1.0
Maternal smoking around birth 0.4 0.6 0.6 -0.8
Fed-up feelings 4.3 7.9 7.9 -2.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.0 -0.2
Relative age voice broke 0.0 0.0 0.0 0.1
Taking other prescription medications 0.7 1.0 1.0 -1.0
Age when periods started (menarche) 0.0 0.0 0.0 0.1
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.0 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.1 0.1 0.4
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.3 -0.6
Qualifications: CSEs or equivalent 0.0 0.0 0.0 0.1
Serious illness, injury or assault to yourself 0.7 0.8 0.8 -0.9
High blood pressure 0.2 0.7 0.7 -0.8
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.1 0.3
Multivitamins +/- minerals 0.0 0.0 0.0 -0.0
Stomach or abdominal pain in last month 0.7 0.8 0.8 -0.9
Supplements: Glucosamine 0.3 0.4 0.4 -0.7
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.5 -0.7
Medication: Atenolol 0.0 0.0 0.0 -0.2
Medication: Levothyroxine sodium 2.2 3.7 3.7 -1.9
Sitting height 1.5 10.5 10.5 -3.2
Chronic bronchitis/emphysema (father) 1.5 1.7 1.7 -1.3
High blood pressure (mother) 0.0 0.0 0.0 -0.2
Body mass index (BMI) 2.8 11.9 11.9 -3.4
Impedance of leg (left) 0.1 0.3 0.3 0.5
Leg predicted mass (left) 3.0 15.8 15.8 -4.0
Trunk fat mass 5.3 22.8 22.8 -4.8
Waist circumference 3.1 11.4 11.4 -3.4
Number of incorrect matches in round 0.1 0.1 0.1 -0.4
Past tobacco smoking 3.4 6.3 6.3 2.5
Alcohol usually taken with meals 1.0 1.6 1.6 1.2
Nervous feelings 0.2 0.4 0.4 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.2 0.5
Hearing difficulty/problems with background noise 1.8 2.9 2.9 -1.7
Hair/balding pattern: Pattern 2 0.1 0.1 0.1 0.4
Had menopause 0.6 0.8 0.8 -0.9
Had other major operations 0.3 0.4 0.4 -0.6
Forced vital capacity (FVC) 0.3 1.3 1.3 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 1.6 1.3
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 0.9 -0.9
Qualifications: None of the above 0.0 0.0 0.0 -0.1
Financial difficulties in last 2 years 1.3 1.8 1.8 -1.3
Mouth/teeth dental problems 2.1 3.3 3.3 1.8
Heart attack 0.3 0.4 0.4 0.7
Allergy 0.1 0.3 0.3 -0.6
Pain all over the body in last month 0.1 0.1 0.1 0.3
Diabetes (self-reported) 0.1 0.1 0.1 0.4
Hayfever/allergic rhinitis (self-reported) 1.7 2.3 2.3 1.5
Medication: Ramipril 0.0 0.0 0.0 -0.2
Medication: Simvastatin 1.9 2.7 2.7 -1.6
Fluid intelligence score 0.9 1.8 1.8 -1.3
Illnesses of siblings 0.0 0.0 0.0 -0.0
Neuroticism score 0.7 1.5 1.5 -1.2
Weight 5.4 26.6 26.6 -5.2
Impedance of arm (right) 0.0 0.0 0.0 -0.1
Arm fat percentage (right) 3.8 15.0 15.0 -3.9
Trunk fat-free mass 2.4 13.6 13.6 -3.7
Hip circumference 6.2 26.7 26.7 -5.2
Time employed in main current job 3.0 3.5 3.5 -1.9
Alcohol intake versus 10 years previously 0.6 0.9 0.9 -0.9
Father’s age at death 0.7 1.0 1.0 1.0
Worrier / anxious feelings 0.0 0.0 0.0 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 0.9 -0.9
Falls in the last year 2.1 2.9 2.9 -1.7
Hair/balding pattern: Pattern 3 0.8 1.2 1.2 -1.1
Number of live births 2.2 3.1 3.1 -1.8
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 1.5 -1.2
Pulse rate 0.0 0.1 0.1 -0.3
Happiness 0.1 0.1 0.1 -0.4
Noisy workplace 1.7 2.1 2.1 -1.5
Qualifications: A levels/AS levels or equivalent 0.4 0.8 0.8 0.9
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.0 -0.0
Mouth/teeth dental problems: Dentures 0.2 0.4 0.4 -0.6
Asthma 0.0 0.0 0.0 0.1
Medication: Ibuprofen (e.g. Nurofen) 5.7 7.3 7.3 -2.7
Medication: Cholesterol lowering 0.2 0.2 0.2 -0.5
Depression (self-reported) 0.7 0.8 0.8 -0.9
Medication: Lansoprazole 0.2 0.3 0.3 -0.5
Prospective memory result 1.5 1.8 1.8 -1.3
Lung cancer (father) 0.7 0.9 0.9 -0.9
Illnesses of mother 0.3 0.4 0.4 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 0.5 -0.7
Pulse wave Arterial Stiffness index 0.1 0.1 0.1 0.3
Impedance of arm (left) 0.0 0.1 0.1 0.3
Arm fat mass (right) 4.9 20.2 20.2 -4.5
Trunk predicted mass 2.4 13.9 13.9 -3.7
Standing height 1.7 17.2 17.2 -4.2
Length of working week for main job 0.4 0.4 0.4 -0.7
Exposure to tobacco smoke at home 0.0 0.0 0.0 -0.1
Breastfed as a baby 0.1 0.2 0.2 -0.4
Tense / ‘highly strung’ 0.6 1.1 1.1 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 1.7 -1.3
Hair/balding pattern: Pattern 4 3.1 7.4 7.4 2.7
Birth weight of first child 0.0 0.0 0.0 0.1
Peak expiratory flow (PEF) 0.0 0.0 0.0 0.1
Pulse wave reflection index 0.0 0.0 0.0 0.1
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.4 -0.6
Loud music exposure frequency 1.8 2.0 2.0 1.4
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 0.7 0.8
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 1.8 -1.3
Blood clot in the leg (DVT) 0.1 0.1 0.1 0.3
Medication: Paracetamol 1.5 2.6 2.6 -1.6
Headache pain in last month 1.6 2.8 2.8 -1.7
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.3 0.6
Glaucoma (self-reported) 0.3 0.3 0.3 0.6
Gout (self-reported) 0.7 0.9 0.9 1.0
Hypothyroidism/myxoedema (self-reported) 2.3 4.6 4.6 -2.1
Medication: Amlodipine 0.6 0.8 0.8 -0.9
Medication: Ventolin 100micrograms inhaler 0.6 0.7 0.7 -0.8
Birth weight 0.0 0.0 0.0 0.2
Chronic bronchitis/emphysema (mother) 0.4 0.4 0.4 0.7
High blood pressure (siblings) 0.5 0.7 0.7 0.8
Forced vital capacity (FVC), Best measure 0.0 0.1 0.1 -0.3
Body fat percentage 4.6 18.1 18.1 -4.2
Leg fat percentage (right) 3.9 14.2 14.2 -3.8
Arm fat-free mass (right) 2.6 13.2 13.2 -3.6
Exposure to tobacco smoke outside home 4.4 5.8 5.8 -2.4
Comparative body size at age 10 0.0 0.1 0.1 0.3
Number of full brothers 0.1 0.2 0.2 -0.4
Worry too long after embarrassment 0.9 1.5 1.5 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.1 -0.4
Wheeze or whistling in the chest in last year 0.4 0.7 0.7 0.8
Number of children fathered 0.1 0.1 0.1 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 0.4 -0.6
Age at first live birth 0.1 0.2 0.2 0.4
Pulse wave peak to peak time 0.2 0.2 0.2 -0.5
Health satisfaction 1.8 2.3 2.3 -1.5
Shortness of breath walking on level ground 4.3 5.2 5.2 -2.3
Qualifications: College or University degree 0.0 0.1 0.1 -0.3
Eye problems/disorders: None of the above 0.8 0.9 0.9 0.9
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.3 -0.6
Emphysema/chronic bronchitis 0.3 0.4 0.4 -0.6
Medication for pain relief, constipation, heartburn 6.3 10.8 10.8 3.3
Neck or shoulder pain in last month 0.1 0.1 0.1 -0.3
Medication: Blood pressure 0.0 0.0 0.0 0.1
Angina (self-reported) 1.6 2.1 2.1 -1.4
Migraine (self-reported) 0.0 0.0 0.0 -0.0
Medication: Ibuprofen 3.3 4.0 4.0 -2.0
Medication: Allopurinol 0.2 0.2 0.2 0.5
Medication: Omeprazole 1.3 1.6 1.6 -1.3
Medication: Seretide 50 evohaler 1.3 1.5 1.5 -1.2
Mean time to correctly identify matches 1.1 2.1 2.1 -1.5
Heart disease (mother) 0.4 0.5 0.5 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.3 -0.5
Whole body fat mass 5.7 23.7 23.7 -4.9
Leg fat mass (right) 5.9 23.0 23.0 -4.8
Arm predicted mass (right) 2.3 11.9 11.9 -3.5
Pulse rate, automated reading 0.0 0.0 0.0 0.0
Alcohol intake frequency. 0.1 0.1 0.1 0.4
Comparative height size at age 10 2.2 12.2 12.2 -3.5
Number of full sisters 2.5 3.1 3.1 -1.7
Suffer from ‘nerves’ 0.4 0.6 0.6 -0.8
Overall health rating 3.1 6.7 6.7 -2.6
Chest pain or discomfort 3.1 4.5 4.5 -2.1
Had major operations 0.8 1.0 1.0 -1.0
Age at last live birth 0.2 0.3 0.3 -0.6
Family relationship satisfaction 0.0 0.0 0.0 0.1
Leg pain on walking 0.7 0.9 0.9 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 0.7 0.8
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.0 -0.1
Illness, injury, bereavement, stress in last 2 years 2.0 2.4 2.4 1.5
Medication: Aspirin 0.9 1.1 1.1 -1.1
Supplements: Vitamin C 0.8 0.9 0.9 -0.9
Knee pain experienced in last month 0.6 0.9 0.9 -1.0
Hypertension (Self-reported) 0.4 1.0 1.0 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.7 2.7 -1.6
Illnesses of father: Heart disease 0.1 0.1 0.1 0.3
Illnesses of siblings: Diabetes 0.1 0.2 0.2 -0.4
Smoking status: Previous 3.8 5.6 5.6 -2.4
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 0.9 -0.9
Whole body fat-free mass 2.5 14.4 14.4 -3.8
Leg fat-free mass (right) 2.7 14.6 14.6 -3.8
Arm fat percentage (left) 3.8 15.1 15.1 -3.9
Average weekly red wine intake 3.3 4.8 4.8 2.2
Handedness (chirality/laterality): Left-handed 0.6 0.7 0.7 0.8
Mood swings 0.6 1.0 1.0 -1.0
Loneliness, isolation 4.0 5.5 5.5 -2.4
Long-standing illness, disability or infirmity 10.4 15.9 15.9 -4.0
Ever had bowel cancer screening 1.3 1.6 1.6 -1.3
Diabetes diagnosed by doctor 0.0 0.0 0.0 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.2 0.2 -0.4
Friendships satisfaction 0.4 0.5 0.5 0.7
Qualifications: nursing, teaching 0.3 0.4 0.4 -0.6
Commuting to job workplace: Walk 0.4 0.5 0.5 0.7
Eye problems/disorders: Cataract 0.9 1.1 1.1 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.0 0.2
Medication for cholesterol 0.3 0.5 0.5 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 0.6 -0.8
Back pain experienced in last month 0.4 0.5 0.5 -0.7
Mineral and other dietary supplements 1.4 1.9 1.9 1.4
Breast cancer (self-reported) 0.5 0.6 0.6 0.7
Asthma (self-reported) 0.0 0.1 0.1 0.2
Osteoporosis (self-reported) 0.0 0.0 0.0 -0.2
Osteoarthritis (self-reported) 0.5 0.6 0.6 0.8
Medication: Aspirin 0.8 1.0 1.0 -1.0
Medication: Gliclazide 0.0 0.0 0.0 -0.2
Illnesses of father: None of the above (group 1) 0.4 0.5 0.5 0.7
Smoking status: Current 0.0 0.1 0.1 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 0.9 0.9
Whole body water mass 2.5 14.0 14.0 -3.7
Leg predicted mass (right) 2.7 14.5 14.5 -3.8
Arm fat mass (left) 4.9 20.1 20.1 -4.5
Number of self-reported non-cancer illnesses 2.6 4.5 4.5 -2.1
Average weekly champagne plus white wine intake 0.5 0.7 0.7 -0.8
Miserableness 0.3 0.6 0.6 -0.8
Guilty feelings 0.4 0.6 0.6 -0.8
Wears glasses or contact lenses 0.5 0.6 0.6 -0.8
Ever taken oral contraceptive pill 4.1 4.6 4.6 -2.1
Hearing aid user 1.6 1.8 1.8 -1.4
Mother’s age at death 0.8 1.0 1.0 -1.0
Financial situation satisfaction 1.6 2.0 2.0 -1.4
Tinnitus: Yes, now most or all of the time 1.6 1.9 1.9 -1.4
Commuting to job workplace: Public transport 1.2 1.4 1.4 -1.2
Eye problems/disorders: Glaucoma 0.0 0.0 0.0 0.1
Medication: Blood pressure 0.3 0.6 0.6 -0.8
Pain type(s) experienced in last month: Hip pain 1.9 2.4 2.4 -1.6
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.3 -0.5
High cholesterol (Self-reported) 0.9 1.6 1.6 -1.3
Medication: Bendroflumethiazide 0.1 0.1 0.1 0.4
Medication: Paracetamol 1.7 2.6 2.6 -1.6
Medication: Lisinopril 0.9 1.2 1.2 1.1
Medication: Atorvastatin 2.0 2.5 2.5 1.6
Illnesses of father: High blood pressure 0.0 0.0 0.0 0.1
Alcohol drinker status: Never 1.0 1.2 1.2 1.1
Ever smoked 3.3 5.8 5.8 -2.4
Basal metabolic rate 3.4 18.8 18.8 -4.3
Leg fat percentage (left) 3.9 14.1 14.1 -3.8
Arm fat-free mass (left) 2.9 14.8 14.8 -3.9
Number of operations (self-reported) 0.3 0.4 0.4 -0.7
Average weekly beer plus cider intake 0.0 0.0 0.0 -0.0
Irritability 0.7 1.1 1.1 -1.1
Risk taking 0.7 1.0 1.0 -1.0
Ever had prostate specific antigen (PSA) test 0.6 0.7 0.7 0.9
Fractured/broken bones in last 5 years 0.0 0.0 0.0 -0.2
Age started oral contraceptive pill 0.2 0.3 0.3 0.5
Diastolic blood pressure, automated reading 0.1 0.2 0.2 -0.4
Ever depressed for a whole week 1.0 1.2 1.2 -1.1
Unable to work because of sickness or disability 1.0 1.3 1.3 -1.1
Commuting to job workplace: Cycle 6.3 7.6 7.6 2.8
Myopia 3.5 5.1 5.1 -2.3
Vascular/heart problems diagnosed by doctor 0.2 0.5 0.5 0.7
Cholesterol lowering medication 1.1 1.6 1.6 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 0.9 -0.9
Pain experienced in last month 0.9 1.4 1.4 1.2
Supplements: Calcium 0.1 0.1 0.1 0.3
Basal cell carcinoma (self-reported) 0.5 0.5 0.5 0.7
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.3 0.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.3 0.5
Heart disease (siblings) 0.1 0.1 0.1 -0.3
Alcohol drinker status: Previous 1.3 1.5 1.5 1.2
Pack years of smoking 1.7 2.5 2.5 -1.6
Impedance of whole body 0.0 0.2 0.2 0.5
Leg fat mass (left) 5.6 21.9 21.9 -4.7
Arm predicted mass (left) 3.1 15.7 15.7 -4.0