Hub : Genes

RP11-483I13.5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.2790 0.0950 6.5e-04 0.232 NA 0.254 NA 0.262 1.2e-06 NA 3.4e-07 NA 2.1e-07
2 GTEx Brain Cerebellum 0.2760 0.0920 5.5e-04 0.294 NA 0.269 NA 0.283 2.4e-09 NA 1.4e-08 NA 5.3e-09
3 GTEx Brain Nucleus accumbens basal ganglia 0.2490 0.0890 2.9e-03 0.060 NA 0.143 NA 0.100 1.1e-02 NA 1.2e-04 NA 1.2e-03
4 GTEx Esophagus Mucosa 0.1340 0.0390 1.6e-05 0.154 NA 0.146 NA 0.134 1.8e-10 NA 5.5e-10 NA 2.8e-09
5 GTEx Muscle Skeletal 0.0611 0.0279 7.0e-03 0.009 NA 0.030 NA 0.026 3.6e-02 NA 5.2e-04 NA 1.1e-03
6 GTEx Nerve Tibial 0.1087 0.0419 3.9e-03 0.035 NA 0.062 NA 0.051 1.5e-03 NA 3.4e-05 NA 1.7e-04
7 GTEx Skin Not Sun Exposed Suprapubic 0.1480 0.0480 1.5e-04 0.142 NA 0.089 NA 0.107 3.4e-08 NA 1.3e-05 NA 1.7e-06
8 ROSMAP Brain Pre-frontal Cortex 0.1108 0.0364 1.0e-06 0.091 0.05 0.101 0.082 0.096 1.0e-11 5.1e-07 7.2e-13 1.1e-10 2.5e-12

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.4 0.7 1.2 0.7 0.9 1.1 -1.1 0.8 -0.6 -0.7 0.0
Bipolar Disorder or Schizophrenia 2.1 5.0 8.6 2.9 2.7 2.1 -2.8 -0.7 -0.3 -2.5 2.3
Depressed Affect (Nagel 2018) 1.4 3.0 9.8 -1.7 -1.5 -3.1 2.1 -0.1 -1.4 1.4 -1.1
Depression (Nagel 2018) 0.2 0.3 0.9 0.4 0.6 -0.9 -0.2 -0.4 0.3 -0.6 0.3
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.5 -0.1 0.1 -1.2 0.0 1.2 -0.5 -0.3 -0.8
Neuroticism (Nagel 2018) 0.3 0.8 2.1 -0.4 -0.4 -1.5 1.2 -0.9 -1.2 0.6 0.0
Schizophrenia (2018) 2.8 5.8 10.2 3.2 2.8 1.8 -2.7 -1.6 0.1 -2.6 2.9
Schizophrenia vs Biploar Disorder 1.1 1.5 3.7 1.4 1.1 1.0 -0.7 -1.7 -0.3 -0.8 1.9
Worry (Nagel 2018) 0.5 1.1 3.0 -0.8 -1.0 -0.6 1.1 -1.7 -0.4 1.2 -0.7
Alzheimer’s Disease (in mother) 2.2 2.6 7.3 1.7 1.7 2.7 -1.2 -1.7 0.1 -1.3 1.4
Alzheimer’s Disease (in father) 1.8 2.0 6.6 -1.0 -1.3 0.0 1.8 -2.6 -0.4 1.6 -0.9
Alzheimer’s Disease (including proxy) 0.5 0.7 3.2 0.2 0.3 1.3 0.3 -1.8 -0.6 -0.1 -0.3
Crohns Disease (2017) 1.0 2.2 4.5 -1.8 -1.2 -2.1 0.8 1.4 -0.9 1.1 -1.9
Irritable Bowel Disease (IBD) 0.4 1.0 3.7 -1.2 -0.6 -1.9 0.7 0.8 -0.6 0.5 -0.9
Ulcerative Colitis (UC) 0.2 0.5 2.3 -0.7 -0.3 -1.5 0.8 -0.1 0.0 0.3 -0.2
Major Depression (MDD) 2.0 2.4 7.4 -1.3 -1.6 -2.7 1.1 0.3 0.3 1.4 -2.1
Reaction Time 2.2 4.2 6.5 2.4 2.4 1.4 -2.2 -1.8 -1.2 -2.1 2.5
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.8 0.3 0.2 -0.8 -0.2 0.5 0.2 -0.3 -0.9
Breast Cancer 0.2 0.6 1.0 -0.9 -1.0 -0.3 0.7 -0.5 -0.8 0.9 -0.5
Ovarian Cancer 0.1 0.1 0.5 -0.2 -0.2 0.7 0.4 -0.3 0.5 0.3 -0.1
Prostate Cancer 0.5 0.8 1.6 1.1 1.1 -0.3 -1.0 1.0 -0.3 -1.3 -0.1
Age at First Birth 0.4 0.5 1.7 0.8 0.4 0.2 -0.6 -0.4 0.9 -0.5 1.3
Bipolar Disorder (2011) 1.8 1.7 5.1 0.4 0.9 1.1 -2.0 2.3 -1.2 -1.1 -0.2
Body Mass Index (BMI) (2010) 0.7 1.0 1.9 -1.1 -1.0 -0.8 0.8 0.4 -1.2 0.8 -1.4
Coronary Artery Disease (CAD) 0.1 0.1 0.4 0.1 0.4 0.3 -0.2 -0.2 0.0 -0.4 0.6
Crohns Disease (2012) 1.5 2.5 5.2 -1.9 -1.6 -1.9 0.8 1.5 -0.1 1.2 -2.3
Mean Putamen Volume 0.6 0.7 2.4 0.9 1.0 0.2 -1.6 0.5 -0.4 -0.9 0.4
Fasting Glucose 1.1 1.3 8.0 0.1 -0.1 0.5 0.5 -2.8 1.1 0.6 0.4
HbA1C 3.0 3.3 5.3 2.3 2.3 1.1 -2.1 -1.3 -0.6 -2.1 1.9
HDL Cholesterol 0.7 1.2 2.8 1.1 1.2 0.4 -1.1 1.7 0.3 -1.3 1.0
LDL Cholesterol 0.5 0.9 2.3 0.8 0.9 1.3 -0.9 0.2 -0.1 -0.7 1.5
Lupus 2.1 3.1 6.2 2.2 2.2 0.8 -1.8 0.7 -1.3 -2.5 1.9
Neuroticism (2016) 1.0 1.5 3.2 1.5 1.5 -0.1 -0.8 0.3 -1.8 -1.4 1.1
Primary Biliary Cirrhosis 3.3 4.6 8.3 2.4 2.7 0.9 -2.7 1.5 -1.2 -2.9 2.0
Rheumatoid Arthritis 0.4 0.6 1.6 -0.2 -0.3 -1.3 0.2 1.0 -0.5 -0.0 -1.2
Schizophrenia (2014) 1.8 4.1 6.8 2.6 2.3 1.6 -2.2 -1.5 -0.4 -2.0 2.6
Triglycerides 0.8 1.3 2.4 -1.3 -1.3 -1.0 1.5 -1.1 -0.2 1.6 -0.6
Type 2 Diabetes (T2D) (2012) 1.0 1.1 3.0 -1.6 -0.8 -1.3 0.1 1.7 0.1 0.5 -0.9
Ulcerative Colitis 0.5 0.8 2.1 -0.9 -0.7 -1.1 1.4 -0.4 0.2 0.8 -0.7
Blood Eosinophil Count 0.3 2.4 11.6 -1.2 -1.1 -3.4 0.9 -0.0 -0.2 0.6 -1.9
Blood Platelet Count 0.1 0.6 3.2 -0.6 -0.6 -0.2 0.5 -1.8 0.6 0.9 0.2
Blood Red Count 0.0 0.4 1.3 -0.2 -0.2 -0.5 0.3 -0.5 1.1 0.2 -1.1
Blood White Count 1.6 11.5 57.9 -0.9 -2.0 -0.6 3.4 -7.6 3.0 2.8 -0.1
Heel T-Score 0.4 3.5 6.0 2.5 2.3 1.3 -2.2 0.4 -0.7 -2.4 2.0
BMI 0.3 1.5 3.1 -1.1 -0.8 -1.6 0.5 1.6 -1.8 0.3 -1.3
Height 0.1 1.5 6.0 -0.3 -0.8 -0.9 1.0 -2.4 1.2 1.3 0.5
Waist Hip Ratio (WHR) 0.1 0.6 1.5 0.4 0.7 0.3 -1.1 1.2 -0.3 -0.9 0.8
Systolic Blood Pressure 0.1 0.6 1.3 0.5 0.7 1.1 -0.3 -0.4 -1.1 -0.5 1.1
Smoking Status 0.1 0.2 0.4 0.3 0.6 -0.4 -0.4 -0.5 0.0 -0.7 -0.1
Allergy or Eczema 0.4 1.0 3.9 -0.4 -0.6 -1.5 0.4 -0.1 -2.0 0.3 -1.2
Cardiovascular Disease 0.1 0.3 0.8 -0.6 -0.4 -0.2 0.9 -0.7 -0.0 0.5 0.3
Hypothyroidism (self reported) 1.1 2.6 11.8 -1.1 -1.1 -0.5 1.1 3.4 0.4 1.0 -2.0
Respiratory disease 0.5 1.0 1.7 -0.9 -0.8 -0.0 1.2 -1.2 1.3 0.8 -1.2
Type 2 Diabetes (T2D) (2018) 0.5 1.0 4.9 -0.4 -0.3 -0.9 -0.3 1.0 -2.2 -0.1 -0.9
Lung FEV1/FVC ratio 0.1 0.5 1.3 0.7 0.7 0.3 -0.5 -0.8 -1.1 -0.5 0.4
Lung FVC 0.3 1.4 2.3 1.4 1.1 1.5 -1.4 1.0 -0.1 -1.1 1.3
Neuroticism 0.2 0.5 1.9 0.1 0.2 -1.3 0.4 -0.3 -1.4 -0.2 0.5
Chronotype (morning person) 2.5 5.7 12.3 2.4 2.4 3.5 -2.9 1.3 0.5 -2.2 2.5
Hair Pigment 0.1 1.5 3.6 1.6 1.0 1.9 -1.0 -0.2 0.9 -1.2 1.4
Tanning 0.0 0.3 1.7 -0.5 -0.5 -0.4 0.1 0.1 -1.3 0.3 -0.0
Hand grip strength (left) 0.7 1.7 10.5 -0.4 -0.5 1.3 0.5 0.8 3.2 0.7 -0.3
Number of treatments/medications taken 0.7 1.3 3.3 -1.8 -1.4 -0.8 1.3 0.7 -0.3 1.1 -1.2
Average weekly spirits intake 0.5 0.6 3.8 0.1 -0.2 0.4 0.4 -2.0 0.6 0.4 -0.0
Sensitivity / hurt feelings 0.2 0.3 1.8 0.1 0.2 -0.5 0.5 0.7 -1.3 -0.2 -0.1
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.1 -0.0 -0.1 -0.7 -0.1 -1.1 0.0 -0.0 0.8
Hearing difficulty/problems: Yes 0.1 0.1 0.3 0.1 0.1 0.1 0.6 -0.4 0.5 -0.3 0.2
Relative age of first facial hair 0.3 0.6 0.9 -0.8 -0.9 -0.8 0.7 -0.2 0.5 1.0 -0.8
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 4.7 -1.1 -1.0 -2.2 1.2 0.1 -0.7 0.8 -1.3
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.9 0.9 0.8 0.1 -0.7 -0.8 -0.0 -0.6 0.8
Ever had hysterectomy (womb removed) 0.2 0.2 1.2 0.1 0.1 0.7 -0.1 1.1 0.2 -0.1 0.3
Systolic blood pressure, automated reading 0.5 1.3 2.9 1.0 1.1 1.0 -1.0 -0.5 -1.5 -0.9 1.7
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 5.2 -0.5 -0.4 -0.2 0.1 0.7 -2.3 0.2 -0.8
Angina 0.9 1.1 1.9 -1.2 -0.8 -1.3 1.4 -0.6 0.6 0.8 -1.4
Medication for hormone replacement therapy 0.2 0.2 0.8 0.2 0.5 0.9 -0.4 0.2 -0.4 -0.4 0.5
Vitamin and mineral supplements 0.6 0.8 1.6 0.9 1.2 0.9 -0.8 -0.0 -0.1 -1.0 1.3
Supplements: Zinc 0.2 0.3 1.0 -0.1 -0.3 -1.0 0.5 -0.3 -0.6 0.2 0.4
Medication: Co-codamol 1.3 1.5 2.5 -1.6 -1.4 -1.4 1.4 0.1 0.3 1.3 -1.5
Medication: Metformin 0.9 1.3 5.7 0.2 0.5 -1.0 -1.1 1.0 -2.4 -0.8 -0.5
Diabetes (father) 0.6 0.7 2.1 0.2 0.2 0.2 0.3 -1.5 -1.4 0.1 1.2
Diabetes (mother) 0.7 0.9 2.1 -1.1 -0.6 -1.1 0.4 1.3 -0.1 0.5 -1.4
Severe depression (siblings) 0.5 0.6 0.9 -0.9 -0.8 -0.9 0.9 -0.2 0.2 0.9 -0.8
Pack years adult smoking proportion 0.5 0.7 1.7 -1.0 -0.5 -1.2 -0.0 0.9 -1.3 0.5 -0.1
Impedance of leg (right) 0.5 2.4 5.3 -1.3 -1.6 0.1 2.1 -2.3 1.0 2.0 -0.5
Leg fat-free mass (left) 0.3 1.5 4.5 0.6 0.9 -0.5 -1.1 1.8 -2.1 -1.2 0.5
Trunk fat percentage 0.1 0.5 1.7 0.1 0.2 -1.3 0.0 -0.2 -1.3 -0.4 0.4
Hand grip strength (right) 0.5 1.5 6.9 0.5 0.6 1.5 -0.6 0.7 2.6 -0.5 1.0
Townsend deprivation index at recruitment 0.1 0.1 0.4 0.1 -0.0 0.0 -0.0 -0.7 -0.1 -0.1 0.5
Current tobacco smoking 2.9 4.7 9.7 2.4 2.8 1.5 -3.1 0.5 -1.1 -2.9 1.7
Average weekly fortified wine intake 0.9 1.1 3.2 -1.3 -1.2 -0.2 1.0 -0.5 -0.5 1.0 -1.8
Maternal smoking around birth 0.1 0.1 0.3 -0.5 0.1 -0.1 0.5 0.5 -0.1 -0.4 -0.4
Fed-up feelings 0.6 1.0 2.6 -0.6 -0.8 -1.6 1.5 -0.7 -1.0 0.9 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.5 2.5 0.2 0.5 -1.6 -0.3 -0.2 -0.4 -0.7 0.3
Relative age voice broke 0.1 0.2 0.4 -0.3 -0.5 -0.2 0.3 0.7 0.3 0.5 -0.4
Taking other prescription medications 1.9 2.9 7.7 -1.7 -1.3 -2.2 0.9 2.8 -1.2 0.9 -1.9
Age when periods started (menarche) 0.5 1.1 2.5 1.6 1.0 0.9 -0.9 -0.6 0.6 -0.9 1.5
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 2.1 0.5 0.6 0.4 -0.6 0.9 -1.5 -0.8 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 3.2 0.6 0.9 -0.1 -1.0 1.8 -1.3 -1.0 0.3
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 2.0 0.7 1.0 -1.1 -0.8 1.4 0.1 -1.2 0.6
Qualifications: CSEs or equivalent 0.4 0.5 1.7 -0.1 -0.3 -1.3 0.0 1.3 -0.7 0.3 -0.3
Serious illness, injury or assault to yourself 1.2 1.4 5.7 -0.2 0.5 -1.7 -0.8 2.4 -1.0 -0.8 -0.3
High blood pressure 0.0 0.1 0.6 0.0 0.1 0.1 0.1 -0.8 0.2 -0.0 0.3
Hayfever, allergic rhinitis or eczema 0.4 0.8 5.5 0.2 0.1 -0.9 -0.2 -0.3 -2.4 -0.3 -0.4
Multivitamins +/- minerals 0.3 0.4 1.2 0.5 0.4 0.7 -0.7 0.4 -1.1 -0.6 -0.1
Stomach or abdominal pain in last month 0.4 0.5 1.5 -0.2 -0.2 -0.8 0.0 -1.1 -1.2 0.3 -0.4
Supplements: Glucosamine 1.0 1.3 2.6 -1.6 -1.5 -0.7 1.0 1.4 0.7 1.1 -0.9
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 2.4 0.8 0.8 -0.1 -1.2 1.3 -1.5 -1.2 0.1
Medication: Atenolol 0.4 0.5 1.5 -1.2 -0.6 0.3 0.8 0.2 -0.6 0.6 -0.9
Medication: Levothyroxine sodium 0.7 1.1 5.0 -0.6 -0.6 -1.1 1.1 2.2 0.1 0.5 -1.0
Sitting height 0.4 2.9 5.2 2.3 2.0 1.9 -1.2 -1.2 -0.4 -1.7 2.1
Chronic bronchitis/emphysema (father) 0.1 0.1 0.8 -0.2 -0.3 0.2 -0.1 -0.9 0.3 0.3 -0.2
High blood pressure (mother) 1.0 1.4 3.5 1.2 1.4 0.2 -1.4 0.1 -1.0 -1.3 1.9
Body mass index (BMI) 0.1 0.4 1.5 0.4 0.5 -0.7 -0.3 0.5 -1.2 -0.7 0.4
Impedance of leg (left) 0.4 2.0 4.6 -1.0 -1.4 -0.1 1.9 -2.1 1.3 1.8 -0.3
Leg predicted mass (left) 0.3 1.5 4.1 0.6 0.9 -0.5 -1.1 1.8 -2.0 -1.2 0.5
Trunk fat mass 0.1 0.6 2.6 0.3 0.4 -1.2 -0.2 0.2 -1.6 -0.6 0.5
Waist circumference 0.1 0.4 1.7 -0.2 0.0 -1.1 0.1 0.2 -1.3 -0.2 -0.1
Number of incorrect matches in round 0.8 1.4 6.6 1.1 0.7 1.2 -0.4 -2.6 0.4 -0.5 0.9
Past tobacco smoking 0.4 0.8 1.5 1.1 1.0 -0.1 -0.8 0.3 -1.2 -0.9 0.9
Alcohol usually taken with meals 0.1 0.2 0.7 0.3 0.3 0.8 -0.2 -0.1 -0.2 -0.4 -0.2
Nervous feelings 0.4 0.7 1.7 -0.5 -0.6 -0.1 0.6 -1.3 -1.2 0.7 -1.0
Frequency of tenseness / restlessness in last 2 weeks 2.8 4.4 7.4 2.6 2.7 0.4 -2.2 -0.7 -1.3 -2.7 2.4
Hearing difficulty/problems with background noise 2.0 3.2 5.6 1.9 2.3 1.3 -1.9 0.3 -0.8 -2.3 2.4
Hair/balding pattern: Pattern 2 0.9 1.2 3.2 -1.2 -1.1 -0.6 0.3 -0.0 -1.4 1.1 -1.8
Had menopause 1.6 2.0 3.8 -1.6 -1.7 -1.1 1.4 -0.3 0.5 1.7 -2.0
Had other major operations 1.1 1.3 4.3 1.5 0.9 0.2 -0.7 -2.1 0.1 -0.6 1.5
Forced vital capacity (FVC) 0.4 1.7 3.6 1.5 1.3 1.9 -1.2 -0.4 0.4 -1.1 1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 9.6 0.6 1.1 0.1 -1.2 3.1 -1.1 -1.4 0.2
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.7 -0.5 -0.8 -1.3 0.7 0.4 -0.0 0.7 -0.6
Qualifications: None of the above 0.2 0.5 2.8 0.0 0.0 -1.7 0.4 -1.0 -0.5 0.0 -0.1
Financial difficulties in last 2 years 3.2 4.3 6.9 2.4 2.6 2.1 -1.9 -1.3 -0.8 -2.5 2.2
Mouth/teeth dental problems 0.4 0.7 2.1 1.0 0.7 0.7 -0.5 -0.7 0.5 -0.7 1.5
Heart attack 0.3 0.4 1.1 -0.6 -0.3 -0.2 0.7 0.7 0.9 0.1 -1.0
Allergy 0.1 0.1 0.3 -0.2 0.2 0.5 -0.3 0.4 0.5 0.1 0.5
Pain all over the body in last month 0.7 0.8 2.3 -0.9 -1.0 -1.5 0.9 -0.5 -0.5 0.7 -0.6
Diabetes (self-reported) 0.7 1.1 6.1 -0.2 0.1 -0.3 -0.6 1.1 -2.5 -0.4 -0.8
Hayfever/allergic rhinitis (self-reported) 0.6 0.9 5.6 -0.1 -0.2 0.5 0.4 -2.4 -0.7 0.5 0.4
Medication: Ramipril 0.4 0.5 2.4 -0.6 -0.5 -0.8 0.5 -0.3 0.1 0.5 -1.5
Medication: Simvastatin 0.8 1.2 3.4 -1.2 -1.0 -1.4 0.5 0.5 0.3 0.8 -1.8
Fluid intelligence score 0.3 0.6 1.4 -0.6 -0.6 -1.2 0.4 1.0 0.4 0.4 -1.0
Illnesses of siblings 0.1 0.1 0.4 -0.2 -0.3 0.7 -0.3 0.5 0.0 0.1 -0.2
Neuroticism score 0.4 0.9 3.3 -0.6 -0.5 -1.8 1.0 0.2 -1.5 0.4 0.1
Weight 0.1 0.3 1.6 0.1 0.2 -0.8 0.0 0.1 -1.3 -0.2 0.3
Impedance of arm (right) 0.1 0.6 3.8 -0.0 -0.1 -0.7 0.2 -2.0 0.2 0.0 0.5
Arm fat percentage (right) 0.2 0.9 3.5 0.4 0.6 -1.3 -0.5 0.1 -1.9 -0.9 0.6
Trunk fat-free mass 0.0 0.2 1.5 -0.1 -0.1 -0.1 0.0 0.6 -1.2 0.2 0.1
Hip circumference 0.2 0.9 1.5 -0.8 -0.8 -1.1 1.2 -1.1 -0.9 0.8 -0.6
Time employed in main current job 0.3 0.3 0.7 0.6 0.5 -0.3 -0.8 0.4 -0.3 -0.5 0.8
Alcohol intake versus 10 years previously 0.3 0.4 1.0 -0.7 -0.3 -1.0 0.2 0.7 0.7 0.3 -0.6
Father’s age at death 0.2 0.2 0.6 0.6 0.3 0.1 -0.7 -0.1 0.6 -0.2 0.8
Worrier / anxious feelings 0.6 1.1 1.6 -1.2 -1.2 -1.0 1.1 -0.5 -1.1 1.1 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 5.9 -0.6 -0.3 -1.1 0.5 1.4 -2.4 0.1 -0.2
Falls in the last year 0.8 1.1 1.7 -1.2 -1.2 -0.8 1.2 -0.3 -1.3 1.1 -0.9
Hair/balding pattern: Pattern 3 0.7 1.0 2.9 0.3 0.7 -0.8 -0.8 1.7 0.6 -0.9 1.3
Number of live births 0.2 0.3 0.9 0.2 0.0 0.5 -0.1 -0.9 1.0 0.0 -0.0
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 4.6 1.9 1.7 2.0 -1.6 -0.5 -0.6 -1.5 2.1
Pulse rate 0.2 0.4 2.0 -0.1 -0.2 1.4 0.3 -0.6 0.2 0.3 -0.6
Happiness 0.1 0.1 0.4 -0.0 -0.3 -0.5 0.4 -0.0 0.6 0.3 0.2
Noisy workplace 0.4 0.5 0.9 0.3 0.8 -0.7 -1.0 0.7 0.9 -0.8 0.6
Qualifications: A levels/AS levels or equivalent 0.5 1.1 2.6 1.0 1.0 0.9 -1.6 0.7 -0.8 -1.1 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 0.9 -0.8 -0.9 -0.9 0.3 0.1 0.8 0.8 -0.8
Mouth/teeth dental problems: Dentures 0.2 0.3 0.9 0.6 0.7 0.2 -0.9 0.4 0.4 -0.5 0.1
Asthma 0.4 0.8 3.9 -0.1 -0.4 -0.4 0.8 -2.0 0.7 0.5 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.7 -1.3 -1.0 0.3 1.1 0.2 0.6 1.0 -1.0
Medication: Cholesterol lowering 0.8 1.2 4.9 -0.9 -0.3 -1.4 -0.4 2.2 -0.7 -0.1 -1.1
Depression (self-reported) 1.5 1.8 5.4 0.5 0.8 -2.3 -1.0 1.2 -2.0 -1.0 1.0
Medication: Lansoprazole 2.9 3.3 5.5 -2.0 -2.0 0.2 2.3 -0.8 2.3 2.1 -1.7
Prospective memory result 0.4 0.5 1.5 0.1 0.4 1.1 -0.8 -0.1 -1.2 -0.5 0.2
Lung cancer (father) 0.3 0.3 1.7 -0.2 -0.6 -0.0 0.3 -1.3 0.0 0.7 0.1
Illnesses of mother 0.5 0.6 1.9 -0.6 -0.8 0.4 1.4 0.0 0.9 0.8 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 2.8 1.6 1.4 1.3 -1.0 -0.6 -0.6 -1.2 1.7
Pulse wave Arterial Stiffness index 0.8 0.9 1.7 1.0 1.2 0.2 -0.9 0.7 -1.2 -1.3 0.8
Impedance of arm (left) 0.1 0.4 2.8 0.1 -0.0 -0.5 0.0 -1.7 0.3 -0.1 -0.0
Arm fat mass (right) 0.1 0.5 2.2 0.2 0.4 -1.1 -0.1 0.2 -1.5 -0.6 0.4
Trunk predicted mass 0.0 0.3 1.7 -0.1 -0.1 -0.0 -0.0 0.7 -1.3 0.1 0.2
Standing height 0.0 0.2 0.4 -0.3 -0.4 0.1 0.4 -0.6 -0.2 0.6 0.0
Length of working week for main job 1.8 2.0 3.6 1.6 1.5 0.3 -1.9 0.4 -1.4 -1.6 1.7
Exposure to tobacco smoke at home 1.8 2.0 3.7 -1.2 -1.2 -1.9 1.6 -1.7 1.2 1.3 -1.0
Breastfed as a baby 0.2 0.3 0.8 0.4 0.1 0.8 -0.6 -0.6 -0.9 0.1 0.4
Tense / ‘highly strung’ 0.7 1.2 8.2 0.3 0.4 -0.5 -0.5 0.5 -2.9 -0.4 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 4.7 -0.1 -0.5 -2.2 0.4 -1.6 -1.1 0.6 -0.2
Hair/balding pattern: Pattern 4 3.2 7.7 11.8 3.4 3.3 2.8 -3.0 0.6 -0.4 -3.3 3.4
Birth weight of first child 1.1 2.0 4.0 -1.4 -1.2 -2.0 0.9 1.4 -1.0 0.9 -2.0
Peak expiratory flow (PEF) 1.6 3.7 7.7 2.1 1.9 2.8 -1.9 -1.4 0.3 -1.6 2.5
Pulse wave reflection index 1.4 1.8 3.9 1.5 1.6 0.5 -1.2 0.7 -1.1 -1.5 2.0
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.3 0.9 0.8 -0.5 -0.2 -0.5 0.3 -0.7 1.1
Loud music exposure frequency 0.5 0.6 1.6 0.2 0.0 -1.0 1.1 -1.3 0.8 0.0 -0.2
Qualifications: O levels/GCSEs or equivalent 0.7 1.2 2.7 0.6 0.9 1.3 -1.6 1.2 -1.1 -1.0 0.3
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.5 -0.3 -0.1 -0.6 0.5 -0.2 -0.1 0.1 -0.7
Blood clot in the leg (DVT) 0.1 0.2 0.4 -0.3 -0.6 0.0 0.4 0.2 0.5 0.4 -0.3
Medication: Paracetamol 0.6 1.0 1.9 -1.4 -1.3 -0.5 1.3 -0.9 0.1 1.4 -0.5
Headache pain in last month 0.3 0.5 2.0 -0.4 -0.2 -1.4 0.0 0.8 -0.9 0.1 -0.4
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 4.5 0.7 0.2 1.5 0.3 -2.1 1.1 0.2 0.9
Glaucoma (self-reported) 3.4 4.0 7.3 2.5 2.7 -0.4 -2.0 -0.7 -1.0 -2.6 2.4
Gout (self-reported) 0.6 0.9 2.2 -1.0 -0.9 -0.9 1.5 1.0 0.4 0.7 -0.8
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 6.6 -0.8 -0.8 -0.2 1.2 2.6 0.2 0.8 -1.6
Medication: Amlodipine 0.6 0.8 1.7 -1.1 -1.1 -1.0 0.4 0.2 0.1 1.0 -1.3
Medication: Ventolin 100micrograms inhaler 0.6 0.7 2.4 0.0 -0.1 1.4 0.7 -1.6 0.7 0.4 0.2
Birth weight 4.5 9.7 14.7 3.7 3.7 1.3 -3.8 -0.3 -2.9 -3.7 3.4
Chronic bronchitis/emphysema (mother) 0.2 0.2 1.4 -0.0 0.1 -0.4 0.4 0.0 -1.2 -0.1 -0.1
High blood pressure (siblings) 0.1 0.1 0.3 -0.1 0.1 -0.6 0.5 -0.2 -0.1 0.0 0.2
Forced vital capacity (FVC), Best measure 0.5 1.8 3.6 1.8 1.5 1.5 -1.1 -0.3 0.2 -1.2 1.9
Body fat percentage 0.1 0.5 1.8 -0.0 0.1 -1.3 0.1 -0.0 -1.4 -0.3 0.3
Leg fat percentage (right) 0.1 0.4 1.0 -0.1 -0.1 -0.9 0.6 -0.8 -1.0 0.2 0.3
Arm fat-free mass (right) 0.1 0.3 1.0 0.1 0.1 0.4 -0.1 1.0 -1.0 -0.1 0.2
Exposure to tobacco smoke outside home 0.2 0.3 0.8 -0.3 0.1 0.8 -0.3 0.6 -0.9 -0.1 -0.6
Comparative body size at age 10 0.7 2.0 4.5 2.1 1.8 -0.1 -1.6 -0.8 -0.3 -1.7 1.4
Number of full brothers 3.0 3.8 8.6 2.1 1.9 2.9 -1.6 -0.4 -0.7 -1.8 2.6
Worry too long after embarrassment 0.1 0.2 0.5 0.3 0.3 -0.1 0.5 0.3 -0.6 -0.3 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 4.0 5.2 8.0 -2.5 -2.3 -2.8 2.2 0.3 -2.6 2.3 -2.3
Wheeze or whistling in the chest in last year 0.1 0.2 0.4 0.4 0.4 -0.3 -0.7 -0.1 0.1 -0.6 0.2
Number of children fathered 0.2 0.2 0.8 -0.0 0.1 -0.9 0.2 -0.2 0.5 0.1 0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 2.7 -1.6 -1.5 -1.4 1.1 0.6 0.6 1.3 -0.3
Age at first live birth 0.4 0.7 4.5 0.4 -0.0 0.2 0.1 -2.1 1.0 0.2 0.1
Pulse wave peak to peak time 0.7 0.9 1.5 -0.9 -1.1 -0.3 0.9 -0.7 1.2 1.2 -0.7
Health satisfaction 0.1 0.2 0.5 -0.0 -0.0 -0.4 0.3 -0.6 -0.7 0.2 0.5
Shortness of breath walking on level ground 0.9 1.1 2.6 -1.1 -0.6 -1.6 0.3 0.8 -1.5 0.3 -1.3
Qualifications: College or University degree 0.1 0.3 0.9 0.8 0.3 0.2 -0.7 -0.2 0.5 -0.3 1.0
Eye problems/disorders: None of the above 1.4 1.6 3.5 1.5 1.3 1.6 -1.1 0.2 0.5 -1.1 1.9
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.2 -0.8 -0.7 -1.0 1.1 0.4 -0.4 0.5 -1.0
Emphysema/chronic bronchitis 0.7 0.8 3.5 -0.3 -0.1 0.7 -0.3 1.3 1.9 -0.1 -0.1
Medication for pain relief, constipation, heartburn 0.8 1.4 3.6 1.9 1.4 0.4 -1.2 -0.8 -0.3 -1.3 1.2
Neck or shoulder pain in last month 0.7 1.1 3.4 -0.6 -0.5 -1.4 1.0 -1.8 0.8 0.6 -0.8
Medication: Blood pressure 0.6 1.1 2.8 -0.9 -0.3 -1.5 0.1 1.7 -1.2 -0.0 -1.1
Angina (self-reported) 0.7 0.9 1.6 -1.0 -0.7 -1.2 1.2 -0.9 0.7 0.7 -1.2
Migraine (self-reported) 0.6 0.8 1.6 1.1 1.1 0.1 -1.1 -0.2 -0.2 -1.3 0.9
Medication: Ibuprofen 1.7 2.0 3.7 -1.9 -1.7 -0.1 1.9 -0.2 1.0 1.8 -1.3
Medication: Allopurinol 1.8 2.3 4.0 -1.7 -1.9 -1.4 2.0 1.0 0.6 1.8 -1.4
Medication: Omeprazole 1.7 2.0 3.9 -2.0 -1.7 -1.3 1.4 0.2 -0.3 1.5 -1.9
Medication: Seretide 50 evohaler 0.1 0.1 0.2 0.4 0.4 -0.2 -0.1 -0.4 -0.1 -0.4 0.3
Mean time to correctly identify matches 1.9 3.7 6.0 2.2 2.3 0.7 -2.5 -0.8 -1.8 -2.1 2.2
Heart disease (mother) 0.3 0.3 1.4 -0.6 -0.6 -1.2 0.5 0.1 0.0 0.4 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.6 4.3 13.0 -1.9 -2.1 -1.4 2.2 -1.0 3.6 2.2 -1.0
Whole body fat mass 0.1 0.6 2.8 0.3 0.5 -1.0 -0.3 0.3 -1.7 -0.6 0.5
Leg fat mass (right) 0.1 0.4 1.8 0.1 0.2 -0.9 0.1 0.3 -1.4 -0.3 0.4
Arm predicted mass (right) 0.1 0.3 1.4 -0.1 -0.1 0.0 0.4 1.0 -1.2 0.2 -0.1
Pulse rate, automated reading 0.9 2.9 5.2 2.3 1.9 1.3 -1.5 -1.6 -1.5 -1.7 1.8
Alcohol intake frequency. 0.3 0.7 1.3 0.8 1.1 -1.2 -0.0 -0.7 -0.4 -0.8 0.9
Comparative height size at age 10 0.1 0.5 1.5 -0.6 -0.7 -0.1 0.3 -0.9 -1.2 0.9 -0.4
Number of full sisters 2.0 2.5 4.8 -2.2 -1.9 -1.7 1.3 -0.1 -0.3 1.9 -1.8
Suffer from ‘nerves’ 0.6 1.0 4.8 -0.3 -0.8 -0.2 1.0 -2.2 -0.4 1.0 -0.3
Overall health rating 0.6 1.3 5.5 -0.2 0.0 -2.0 0.0 -0.7 -2.4 -0.0 -0.7
Chest pain or discomfort 1.5 2.1 3.6 -1.3 -1.4 -1.9 1.8 -1.7 0.3 1.5 -1.0
Had major operations 1.1 1.3 2.0 -1.1 -1.4 -1.1 1.2 0.9 0.4 1.3 -1.4
Age at last live birth 2.1 3.0 13.3 1.5 0.8 1.6 -0.1 -3.6 2.0 -0.3 1.1
Family relationship satisfaction 1.1 1.4 4.0 1.5 1.0 0.2 -0.2 -1.4 1.2 -0.7 2.0
Leg pain on walking 0.8 1.0 1.6 -0.7 -0.9 -0.7 1.1 -0.6 1.2 1.1 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.6 -0.6 -0.3 0.4 0.7 0.6 0.8 0.2 -0.8
Commuting to job workplace: Car/motor vehicle 1.1 1.3 1.9 1.2 1.4 -0.5 -1.4 1.1 -1.1 -1.2 1.0
Illness, injury, bereavement, stress in last 2 years 1.0 1.3 4.1 1.0 0.8 2.0 -0.6 -1.1 -0.2 -0.5 1.6
Medication: Aspirin 1.0 1.4 5.4 -0.9 -0.5 -1.4 0.3 2.3 -1.0 0.2 -1.2
Supplements: Vitamin C 2.5 2.9 5.5 -1.7 -2.3 -1.6 1.7 -1.1 1.3 2.3 -1.0
Knee pain experienced in last month 0.4 0.7 1.7 -1.3 -0.7 -0.7 0.9 0.6 -0.7 0.6 -0.7
Hypertension (Self-reported) 0.1 0.3 0.6 -0.6 -0.5 -0.7 0.8 -0.6 0.1 0.5 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.3 3.8 7.3 -2.1 -2.1 0.1 2.7 -1.4 1.9 2.3 -1.9
Illnesses of father: Heart disease 0.9 1.3 2.6 1.4 1.6 -0.6 -0.9 -0.6 -0.5 -1.5 1.3
Illnesses of siblings: Diabetes 0.4 0.5 1.3 -0.6 -0.6 -0.7 0.7 0.3 -0.3 0.7 -1.1
Smoking status: Previous 1.7 2.6 4.0 -1.9 -1.9 -0.5 1.8 -0.3 2.0 1.8 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.8 0.4 0.3 0.2 0.0 -0.9 -0.4 -0.2 0.2
Whole body fat-free mass 0.1 0.5 2.4 0.1 0.2 -0.3 -0.3 1.2 -1.5 -0.3 0.2
Leg fat-free mass (right) 0.3 1.5 3.4 0.8 1.1 -0.5 -1.3 1.8 -1.7 -1.3 0.6
Arm fat percentage (left) 0.2 0.9 3.0 0.6 0.8 -1.0 -0.7 0.1 -1.7 -1.1 0.6
Average weekly red wine intake 1.8 2.6 5.2 1.8 1.7 1.8 -2.3 0.3 -1.1 -2.0 1.1
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.2 -0.9 -1.1 -0.8 0.8 0.3 -0.3 0.9 -0.5
Mood swings 1.2 2.2 8.3 -1.3 -1.2 -2.9 1.3 -0.2 -1.7 1.1 -0.7
Loneliness, isolation 0.1 0.2 0.4 -0.4 -0.3 -0.6 0.4 -0.5 -0.3 0.2 0.3
Long-standing illness, disability or infirmity 1.1 1.7 5.8 -0.6 -0.4 -1.8 0.0 1.4 -2.4 -0.0 -1.4
Ever had bowel cancer screening 1.1 1.2 2.7 1.2 1.0 0.3 -1.7 0.4 -1.2 -1.2 1.1
Diabetes diagnosed by doctor 0.8 1.4 8.8 -0.1 0.2 -0.5 -0.7 0.7 -3.0 -0.4 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 3.6 0.7 0.8 -0.3 -1.1 -1.2 -1.9 -0.9 0.8
Friendships satisfaction 0.4 0.5 1.6 0.4 -0.0 -0.6 -0.2 -0.9 1.0 0.3 1.3
Qualifications: nursing, teaching 0.4 0.6 1.8 -0.8 -0.8 -1.4 0.4 -0.6 0.2 0.8 -0.4
Commuting to job workplace: Walk 0.6 0.7 2.0 -0.6 -1.0 -0.1 0.2 -1.4 0.4 1.0 -0.8
Eye problems/disorders: Cataract 2.7 3.1 7.1 -2.1 -2.2 -1.7 1.5 0.0 -0.3 1.9 -2.7
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 4.2 -1.8 -1.7 -1.0 2.1 0.1 1.0 1.6 -1.6
Medication for cholesterol 0.0 0.1 0.3 0.2 0.1 -0.2 -0.2 0.5 0.2 -0.2 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 1.1 0.1 -0.1 1.1 -0.0 0.9 0.0 0.0 0.4
Back pain experienced in last month 1.0 1.4 2.3 1.3 1.3 1.1 -1.2 -0.7 -1.0 -1.2 1.5
Mineral and other dietary supplements 0.3 0.5 1.9 0.8 0.5 0.9 0.0 -1.4 0.4 -0.0 0.2
Breast cancer (self-reported) 1.2 1.5 2.6 1.4 1.5 1.4 -1.2 -0.4 -0.2 -1.3 1.6
Asthma (self-reported) 0.4 0.8 4.7 -0.0 -0.3 -0.2 0.8 -2.2 0.9 0.4 -0.4
Osteoporosis (self-reported) 0.9 1.2 6.1 0.2 0.8 -0.5 -1.1 0.5 -2.5 -0.8 -0.4
Osteoarthritis (self-reported) 1.2 1.6 2.8 -1.4 -1.6 -1.1 1.3 -1.0 -0.8 1.7 -0.8
Medication: Aspirin 0.9 1.1 3.8 -0.9 -0.6 -1.1 0.5 2.0 -0.9 0.4 -1.2
Medication: Gliclazide 0.2 0.2 1.0 0.0 0.1 -0.2 0.0 -1.0 -0.6 0.0 0.2
Illnesses of father: None of the above (group 1) 0.6 0.7 1.4 -0.9 -1.2 -0.0 0.6 0.9 0.9 1.1 -0.6
Smoking status: Current 3.4 5.4 10.6 2.5 3.0 1.8 -3.2 0.7 -1.1 -3.0 1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.6 0.2 -0.1 0.0 0.8 -0.6 0.5 0.2 0.1
Whole body water mass 0.1 0.6 2.5 0.2 0.3 -0.2 -0.4 1.2 -1.6 -0.4 0.3
Leg predicted mass (right) 0.3 1.4 3.5 0.7 1.0 -0.5 -1.2 1.9 -1.7 -1.2 0.6
Arm fat mass (left) 0.2 0.7 3.0 0.5 0.6 -0.9 -0.4 0.2 -1.7 -0.8 0.6
Number of self-reported non-cancer illnesses 1.2 2.0 3.6 -1.9 -1.7 -1.1 1.9 -0.3 -0.4 1.6 -1.6
Average weekly champagne plus white wine intake 0.1 0.2 0.6 0.1 -0.1 0.7 -0.1 -0.7 -0.5 0.1 0.5
Miserableness 0.5 0.8 2.2 0.5 0.5 -1.2 0.1 0.1 -1.5 -0.6 1.5
Guilty feelings 0.7 1.0 3.5 0.9 1.0 0.3 -0.4 0.7 -1.2 -1.0 1.9
Wears glasses or contact lenses 0.6 0.7 1.5 0.8 0.7 0.3 -1.0 0.4 -1.2 -0.9 0.8
Ever taken oral contraceptive pill 1.0 1.1 4.3 -0.6 -0.1 -0.1 -0.2 2.1 -1.9 -0.3 -0.6
Hearing aid user 0.3 0.3 0.7 -0.6 -0.3 0.3 0.6 0.8 0.7 -0.0 -0.7
Mother’s age at death 0.5 0.7 2.2 -0.8 -0.9 -1.5 0.4 -0.3 0.6 0.9 -0.8
Financial situation satisfaction 0.4 0.5 1.9 0.7 0.6 0.7 -0.3 -0.7 -0.4 -0.4 1.4
Tinnitus: Yes, now most or all of the time 2.0 2.3 3.8 -1.8 -1.8 -0.5 1.9 -0.7 1.2 1.6 -1.9
Commuting to job workplace: Public transport 1.1 1.3 4.6 -1.2 -1.0 1.0 0.7 -0.4 2.1 1.0 -0.9
Eye problems/disorders: Glaucoma 2.1 2.5 3.7 1.8 1.9 -0.2 -1.4 -1.5 -1.2 -1.8 1.9
Medication: Blood pressure 0.2 0.5 2.1 -0.1 -0.4 0.5 0.4 -1.4 0.8 0.6 -0.3
Pain type(s) experienced in last month: Hip pain 0.6 0.8 2.2 -0.0 0.3 -0.3 -0.9 1.5 -1.5 -0.6 -0.6
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.9 -0.9 -0.6 -0.6 0.0 0.8 -0.1 0.3 -0.9
High cholesterol (Self-reported) 0.1 0.2 0.4 -0.2 -0.0 -0.6 -0.2 0.7 0.2 0.0 0.6
Medication: Bendroflumethiazide 2.1 3.1 5.6 2.2 2.0 0.8 -2.0 1.0 -1.3 -2.4 1.8
Medication: Paracetamol 2.0 3.0 5.4 -2.3 -2.2 -1.5 2.3 0.1 0.8 2.1 -1.2
Medication: Lisinopril 1.9 2.5 4.2 -2.0 -2.0 -0.7 1.8 0.0 -0.1 1.9 -1.9
Medication: Atorvastatin 0.6 0.7 2.8 0.1 -0.0 0.4 0.5 -1.2 1.7 0.5 1.1
Illnesses of father: High blood pressure 0.8 1.0 4.8 0.7 0.8 -0.9 -0.8 0.5 -2.2 -0.7 0.2
Alcohol drinker status: Never 0.1 0.2 0.4 -0.1 -0.4 -0.6 0.4 0.4 0.4 0.2 -0.5
Ever smoked 0.4 0.7 0.9 -0.9 -1.0 -0.1 0.7 -0.9 0.9 0.9 -0.9
Basal metabolic rate 0.1 0.5 2.5 0.3 0.4 -0.4 -0.4 1.0 -1.6 -0.5 0.4
Leg fat percentage (left) 0.1 0.3 1.3 0.1 0.0 -1.1 0.4 -0.6 -0.8 0.0 0.4
Arm fat-free mass (left) 0.1 0.4 2.0 -0.1 -0.1 -0.2 0.3 0.9 -1.4 0.2 0.3
Number of operations (self-reported) 0.4 0.6 1.3 1.0 0.6 1.1 -0.5 -0.8 -0.2 -0.5 0.9
Average weekly beer plus cider intake 0.5 0.7 3.1 -0.5 -0.0 -1.2 -0.2 1.8 -0.8 -0.1 -0.0
Irritability 1.2 2.1 3.2 1.2 1.6 0.4 -1.6 1.2 -1.6 -1.8 1.7
Risk taking 0.4 0.6 2.6 -0.5 -0.2 0.1 0.3 1.3 1.6 0.1 -0.6
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.2 -0.8 -0.6 -0.6 -0.1 0.8 -0.4 0.4 -1.1
Fractured/broken bones in last 5 years 1.9 2.5 3.7 -1.8 -1.8 -1.9 1.7 -1.0 0.6 1.6 -1.7
Age started oral contraceptive pill 1.5 1.8 12.2 0.5 0.1 0.6 0.9 -3.5 0.7 0.4 0.5
Diastolic blood pressure, automated reading 0.4 1.3 4.0 0.9 0.6 1.1 -0.5 -2.0 -1.1 -0.3 1.6
Ever depressed for a whole week 0.4 0.5 0.8 -0.9 -0.9 -0.6 0.6 0.5 -0.9 0.7 -0.3
Unable to work because of sickness or disability 0.7 0.9 3.1 0.7 0.8 -0.2 -1.2 -0.1 -1.8 -1.1 0.6
Commuting to job workplace: Cycle 0.3 0.3 1.4 -0.2 -0.5 1.2 0.3 -0.4 0.1 0.4 -0.6
Myopia 0.8 1.1 1.9 1.2 1.4 1.3 -1.1 0.9 0.1 -1.3 0.6
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.3 0.3 0.0 0.2 -0.3 0.5 0.2 -0.1 0.1
Cholesterol lowering medication 0.1 0.2 0.9 0.3 0.3 0.2 -0.3 -0.3 -0.0 -0.2 0.9
Medication: Omeprazole (e.g. Zanprol) 2.3 2.8 4.7 -2.2 -2.1 -1.4 2.0 -0.8 0.1 2.0 -1.7
Pain experienced in last month 0.3 0.5 2.5 0.1 -0.0 0.6 -0.4 1.6 -0.9 -0.1 -0.2
Supplements: Calcium 0.3 0.3 1.7 0.2 0.1 -0.6 0.3 -0.3 -1.3 -0.0 0.1
Basal cell carcinoma (self-reported) 0.4 0.5 2.0 -0.2 -0.3 0.7 -0.5 1.0 -1.4 -0.0 -0.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.1 -0.5 -0.1 -0.4 0.6 1.0 0.5 -0.2 -1.1
Deep venous thrombosis (DVT) (self-reported) 0.0 0.1 0.2 -0.1 -0.4 0.4 0.1 0.4 0.0 0.1 -0.1
Heart disease (siblings) 0.5 0.6 1.0 1.0 0.9 0.9 -0.7 0.7 -0.2 -0.8 0.9
Alcohol drinker status: Previous 0.8 0.9 1.7 1.3 1.3 0.2 -0.8 -0.3 0.5 -1.2 1.1
Pack years of smoking 0.8 1.1 2.5 -1.3 -0.8 -1.4 0.1 1.3 -1.6 0.7 -0.4
Impedance of whole body 0.2 0.9 3.8 -0.5 -0.7 -0.1 1.1 -1.9 1.0 0.9 -0.2
Leg fat mass (left) 0.1 0.3 1.2 0.2 0.3 -0.9 0.0 0.3 -1.1 -0.4 0.5
Arm predicted mass (left) 0.0 0.2 0.7 -0.1 -0.2 -0.3 0.4 0.6 -0.9 0.2 0.3