Hub : Genes

RP11-513M16.7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.108	0.0391	0.00110	0.030	NA	0.016	NA	0.037	2.1e-03	NA	0.01800	NA	7.0e-04
2	GTEx	Brain Cerebellum	0.435	0.1050	0.00019	0.214	NA	0.118	NA	0.179	5.9e-07	NA	0.00024	NA	5.6e-06
3	GTEx	Brain Nucleus accumbens basal ganglia	0.306	0.0950	0.00180	0.111	NA	0.079	NA	0.169	6.8e-04	NA	0.00390	NA	2.8e-05
4	GTEx	Stomach	0.199	0.0710	0.00170	0.098	NA	0.051	NA	0.086	2.1e-05	NA	0.00180	NA	6.2e-05
5	GTEx	Uterus	0.674	0.1090	0.00048	-0.003	NA	0.027	NA	0.020	3.8e-01	NA	0.09300	NA	1.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.8	2.8	6.7	-1.1	-1.2	-1.6	-1.5	2.6
Bipolar Disorder or Schizophrenia	0.2	0.5	1.9	0.4	-0.2	-0.3	-0.4	1.4
Depressed Affect (Nagel 2018)	0.9	1.9	4.8	-0.2	-2.2	-0.7	-2.0	-0.3
Depression (Nagel 2018)	0.4	0.6	1.8	0.1	-0.9	0.1	-0.6	1.3
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.9	0.7	1.2	1.4	1.3	0.1
Neuroticism (Nagel 2018)	0.5	1.2	3.1	0.0	-1.8	-0.3	-1.5	0.7
Schizophrenia (2018)	0.4	0.8	1.9	1.4	0.7	0.9	0.7	-0.2
Schizophrenia vs Biploar Disorder	0.5	0.6	1.1	0.5	-1.0	-0.5	-0.8	-1.0
Worry (Nagel 2018)	0.8	1.6	3.5	-0.5	-1.4	-0.3	-1.5	1.9
Alzheimer’s Disease (in mother)	0.5	0.6	1.8	-1.2	-0.0	0.1	-0.0	1.3
Alzheimer’s Disease (in father)	0.2	0.2	0.8	0.9	0.3	0.0	0.3	0.2
Alzheimer’s Disease (including proxy)	0.7	1.1	4.0	-1.0	0.6	0.1	0.1	2.0
Crohns Disease (2017)	0.4	0.8	2.4	0.4	0.8	1.5	0.3	0.8
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	-0.0	0.5	0.3	0.3	0.3
Ulcerative Colitis (UC)	0.1	0.3	1.0	-0.5	-0.1	-1.0	-0.1	-0.2
Major Depression (MDD)	0.2	0.3	0.7	-0.6	-0.8	-0.3	-0.4	0.3
Reaction Time	2.0	3.8	6.5	-2.6	-2.3	-1.5	-2.1	0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	0.4	0.8	0.9	0.6	-0.2
Breast Cancer	0.3	0.7	1.4	0.3	-1.2	0.2	-1.2	0.9
Ovarian Cancer	0.0	0.0	0.1	-0.1	0.3	0.0	0.0	-0.0
Prostate Cancer	1.0	1.4	2.2	-0.9	-1.5	-1.3	-1.4	-0.4
Age at First Birth	0.2	0.2	1.0	-1.0	0.2	-0.1	0.1	0.2
Bipolar Disorder (2011)	2.4	2.3	4.6	-1.0	-1.9	-1.5	-2.1	-0.1
Body Mass Index (BMI) (2010)	0.5	0.6	0.9	0.4	0.9	1.0	1.0	-0.7
Coronary Artery Disease (CAD)	1.0	1.2	2.5	0.6	1.1	1.6	1.2	0.6
Crohns Disease (2012)	0.6	1.0	3.7	-0.9	0.3	0.5	-0.2	1.9
Mean Putamen Volume	0.7	0.8	1.3	-0.9	-1.0	-0.3	-1.1	0.9
Fasting Glucose	0.1	0.1	0.2	0.3	0.0	0.4	0.1	-0.4
HbA1C	1.9	2.1	4.1	0.8	2.0	1.1	2.0	-0.4
HDL Cholesterol	0.5	0.9	1.5	1.2	0.3	1.0	0.6	-1.1
LDL Cholesterol	5.2	8.2	16.2	1.8	3.4	4.0	3.2	-0.0
Lupus	1.0	1.5	3.9	1.8	0.2	-0.2	0.3	-2.0
Neuroticism (2016)	2.0	2.8	3.7	-1.4	-1.9	-1.6	-1.6	1.8
Primary Biliary Cirrhosis	1.0	1.4	2.7	1.0	1.3	1.3	1.7	-0.1
Rheumatoid Arthritis	1.1	1.5	2.8	-0.7	-1.1	-1.1	-1.4	1.7
Schizophrenia (2014)	0.2	0.5	0.8	0.9	-0.9	-0.4	-0.8	-0.1
Triglycerides	0.6	1.0	2.0	0.1	1.4	0.9	1.4	0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.7	-0.0	0.6	-0.3	-0.3
Ulcerative Colitis	0.1	0.2	0.8	-0.1	-0.3	-0.9	-0.1	0.0
Blood Eosinophil Count	0.2	1.6	3.1	-0.9	-1.8	-1.1	-1.4	0.9
Blood Platelet Count	0.6	7.2	11.1	-2.9	-2.7	-3.3	-2.8	1.3
Blood Red Count	0.3	3.2	8.0	-2.8	-1.1	-0.9	-0.7	2.3
Blood White Count	0.9	6.6	12.8	-2.0	-3.6	-2.9	-2.7	0.5
Heel T-Score	0.1	0.4	1.3	-0.8	0.1	-1.1	-0.4	0.4
BMI	0.2	0.9	1.3	-1.1	-1.1	-1.1	-0.6	0.6
Height	0.2	3.1	8.4	-1.6	-0.9	0.9	-1.8	2.9
Waist Hip Ratio (WHR)	0.0	0.1	0.3	-0.5	-0.1	-0.3	0.1	0.4
Systolic Blood Pressure	3.9	19.6	30.9	5.6	4.3	3.7	4.5	-3.8
Smoking Status	0.2	0.6	2.1	1.4	-0.7	-0.3	-0.2	-0.3
Allergy or Eczema	0.0	0.1	0.3	0.2	0.4	0.0	0.5	0.2
Cardiovascular Disease	5.4	18.0	26.4	4.6	4.7	4.3	5.1	-1.2
Hypothyroidism (self reported)	0.3	0.6	1.1	1.0	0.3	0.9	0.3	-1.0
Respiratory disease	0.2	0.5	1.5	1.2	0.2	0.7	0.5	0.5
Type 2 Diabetes (T2D) (2018)	1.3	2.4	3.6	1.1	1.8	1.8	1.9	0.6
Lung FEV1/FVC ratio	0.0	0.2	0.6	-0.5	-0.3	0.2	-0.4	0.8
Lung FVC	0.1	0.7	1.6	1.3	0.1	-0.4	0.1	-1.2
Neuroticism	0.5	1.2	3.3	-0.0	-1.8	-0.2	-1.6	0.3
Chronotype (morning person)	0.7	1.7	3.2	0.8	1.3	1.8	1.2	1.1
Hair Pigment	0.4	10.7	17.3	2.8	4.1	3.3	4.2	-0.1
Tanning	0.0	0.4	1.5	0.4	-0.1	-0.5	-0.0	-1.2
Hand grip strength (left)	0.2	0.5	1.2	-1.0	0.3	1.1	0.2	0.2
Number of treatments/medications taken	0.4	0.7	1.7	1.3	0.5	0.4	0.8	-0.9
Average weekly spirits intake	1.2	1.5	2.4	-1.3	-1.2	-1.5	-1.1	-0.7
Sensitivity / hurt feelings	1.3	2.3	3.5	-1.4	-1.8	-0.6	-1.9	1.6
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	0.5	-0.3	-0.1	0.2	0.5
Hearing difficulty/problems: Yes	0.3	0.4	1.2	-0.3	-0.6	0.5	-0.6	1.1
Relative age of first facial hair	0.1	0.2	0.5	-0.3	0.3	0.1	0.7	0.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.7	0.0	-0.3	0.9	-0.0	0.3
Ever used hormone-replacement therapy (HRT)	1.0	1.2	4.9	2.2	-0.0	0.9	0.4	-0.6
Ever had hysterectomy (womb removed)	0.2	0.3	0.6	0.8	0.2	0.7	0.3	-0.5
Systolic blood pressure, automated reading	3.0	8.7	14.3	3.8	2.9	2.8	3.0	-2.0
Eye problems/disorders: Diabetes related eye disease	3.1	3.4	5.9	2.0	1.8	2.4	1.9	-0.7
Angina	1.5	1.9	4.6	1.0	1.4	2.1	1.2	0.9
Medication for hormone replacement therapy	1.1	1.3	3.9	2.0	0.2	0.2	0.3	-1.5
Vitamin and mineral supplements	0.6	0.8	1.6	-0.8	-0.9	-1.3	-0.9	0.2
Supplements: Zinc	1.4	1.5	6.5	-0.6	0.6	-0.1	0.6	2.5
Medication: Co-codamol	0.1	0.1	0.4	0.1	-0.2	0.6	-0.0	-0.5
Medication: Metformin	0.6	0.8	3.8	-0.5	0.3	0.3	0.0	1.9
Diabetes (father)	0.4	0.5	1.9	1.4	-0.7	-0.0	-0.4	0.1
Diabetes (mother)	0.5	0.7	1.5	1.2	0.9	0.9	0.6	-0.3
Severe depression (siblings)	0.9	1.0	2.0	0.7	1.2	0.7	1.4	-0.9
Pack years adult smoking proportion	1.2	1.9	3.6	-1.0	-1.5	-0.9	-1.3	1.9
Impedance of leg (right)	0.8	3.7	4.9	1.7	2.2	2.1	1.9	1.6
Leg fat-free mass (left)	0.6	3.1	4.5	-2.0	-2.1	-1.5	-2.1	0.3
Trunk fat percentage	0.7	2.6	6.2	-1.7	-1.2	-1.2	-1.1	2.5
Hand grip strength (right)	0.2	0.5	1.0	-0.9	0.5	1.0	0.3	0.2
Townsend deprivation index at recruitment	0.9	1.2	3.2	1.4	0.5	0.6	0.5	-1.8
Current tobacco smoking	0.2	0.4	0.7	-0.4	-0.9	-0.7	-0.5	0.6
Average weekly fortified wine intake	0.1	0.1	0.3	-0.2	-0.1	0.2	-0.4	0.5
Maternal smoking around birth	1.3	1.8	6.5	1.5	0.1	-0.5	0.4	-2.5
Fed-up feelings	0.4	0.8	1.4	0.6	-1.2	0.2	-1.1	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	6.5	-1.2	-0.9	0.1	-0.8	2.5
Relative age voice broke	0.3	0.4	1.1	0.2	0.3	0.7	0.5	-1.0
Taking other prescription medications	0.3	0.4	0.6	0.8	0.7	-0.1	0.7	-0.7
Age when periods started (menarche)	0.2	0.5	1.0	-0.9	-0.7	-0.3	-1.0	-0.3
Bilateral oophorectomy (both ovaries removed)	3.6	4.1	8.4	2.9	0.9	1.0	1.4	-2.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.7	0.4	0.4	0.2	0.4	1.3
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	4.8	1.0	-0.6	-0.3	-0.6	-2.2
Qualifications: CSEs or equivalent	0.7	0.9	1.8	-1.0	-0.3	-1.3	-0.3	1.1
Serious illness, injury or assault to yourself	0.1	0.2	0.7	0.2	-0.2	-0.2	0.2	0.8
High blood pressure	2.0	5.7	9.5	3.1	1.7	2.7	2.1	-2.0
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.3	-0.2	0.4	-0.2	0.5	0.4
Multivitamins +/- minerals	1.4	1.7	3.9	1.6	1.1	2.0	1.1	-0.1
Stomach or abdominal pain in last month	1.5	1.9	3.7	-1.0	-1.6	-1.9	-1.5	0.1
Supplements: Glucosamine	0.5	0.7	2.8	-0.4	-0.5	-0.4	-0.4	-1.7
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.3	1.4	1.3	0.2	1.5	-0.1
Medication: Atenolol	0.1	0.1	0.3	0.6	0.1	0.3	0.1	0.0
Medication: Levothyroxine sodium	0.4	0.7	1.6	-0.0	-1.3	-0.3	-1.0	-1.0
Sitting height	0.1	0.4	1.2	-0.3	0.7	1.1	0.1	-0.5
Chronic bronchitis/emphysema (father)	2.6	3.1	5.1	-1.8	-2.1	-2.3	-1.5	0.6
High blood pressure (mother)	0.3	0.4	1.5	1.2	0.0	0.2	-0.1	-0.8
Body mass index (BMI)	0.5	2.2	3.3	-1.6	-1.6	-1.8	-1.2	1.1
Impedance of leg (left)	0.7	3.4	5.1	1.6	2.2	1.9	1.9	1.5
Leg predicted mass (left)	0.5	2.8	4.2	-1.9	-2.1	-1.4	-2.0	0.2
Trunk fat mass	0.6	2.6	4.5	-1.9	-1.3	-1.3	-1.3	2.1
Waist circumference	0.8	2.9	3.6	-1.9	-1.8	-1.8	-1.5	1.6
Number of incorrect matches in round	0.1	0.2	0.3	0.5	-0.2	0.5	-0.3	-0.5
Past tobacco smoking	0.7	1.2	3.2	-1.8	-0.7	-0.5	-0.9	1.2
Alcohol usually taken with meals	0.3	0.4	1.3	0.1	0.6	0.0	0.7	1.2
Nervous feelings	0.3	0.6	1.3	-0.2	-0.9	0.2	-1.1	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	5.5	-0.6	-2.3	-0.6	-2.0	0.6
Hearing difficulty/problems with background noise	0.3	0.5	2.0	0.5	0.2	1.4	0.3	0.0
Hair/balding pattern: Pattern 2	1.7	2.1	5.2	-1.3	-1.4	-2.3	-1.3	-0.3
Had menopause	0.1	0.1	0.3	-0.3	-0.3	-0.5	0.1	-0.1
Had other major operations	0.3	0.3	0.6	-0.7	-0.4	-0.8	0.0	0.5
Forced vital capacity (FVC)	0.0	0.1	0.2	0.0	0.4	-0.3	0.1	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.6	-0.2	-0.5	-1.0	-0.6	1.2
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.5	-0.9	-1.6	-0.4	-1.2	-0.4
Qualifications: None of the above	0.1	0.2	0.5	0.5	-0.7	-0.0	-0.4	-0.4
Financial difficulties in last 2 years	1.7	2.2	3.3	1.8	1.5	1.2	1.7	-1.1
Mouth/teeth dental problems	0.8	1.2	3.2	-0.4	1.8	0.8	1.5	-0.0
Heart attack	0.9	1.1	2.2	0.8	1.5	1.2	1.1	-0.0
Allergy	0.1	0.2	0.7	-0.3	0.0	-0.2	-0.0	-0.9
Pain all over the body in last month	2.1	2.3	5.0	-0.2	-2.2	-1.1	-2.0	-0.9
Diabetes (self-reported)	0.1	0.2	0.5	-0.1	0.5	0.7	0.4	0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.5	-0.6	0.0	-0.8	0.3
Medication: Ramipril	0.1	0.1	0.3	0.6	0.1	0.4	0.1	-0.4
Medication: Simvastatin	2.4	3.5	6.5	1.8	2.5	1.4	2.4	-0.7
Fluid intelligence score	0.1	0.1	0.3	0.2	-0.0	0.5	-0.2	-0.5
Illnesses of siblings	0.5	0.7	1.7	-1.3	0.2	-0.3	-0.4	1.3
Neuroticism score	0.8	1.7	3.9	-0.3	-2.0	-0.3	-1.9	1.0
Weight	0.5	2.6	3.8	-2.0	-1.6	-1.5	-1.5	1.4
Impedance of arm (right)	0.2	0.8	3.2	0.1	0.0	0.9	0.1	1.8
Arm fat percentage (right)	0.5	2.1	3.0	-1.6	-1.5	-1.4	-1.0	1.7
Trunk fat-free mass	0.2	1.0	1.5	-1.2	-1.1	-0.8	-1.2	-0.2
Hip circumference	0.5	2.3	2.9	-1.6	-1.7	-1.3	-1.5	1.5
Time employed in main current job	2.2	2.6	4.1	-2.0	-1.7	-1.3	-2.0	0.4
Alcohol intake versus 10 years previously	0.4	0.6	1.6	0.9	-0.2	1.2	0.3	0.7
Father’s age at death	0.6	0.8	1.7	-1.0	-0.7	-0.6	-0.7	1.3
Worrier / anxious feelings	1.0	1.9	3.5	-0.9	-1.9	-0.9	-1.7	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	1.1	-0.5	1.0	-0.2	-0.3
Falls in the last year	0.9	1.3	2.8	-0.2	1.3	1.1	1.7	0.8
Hair/balding pattern: Pattern 3	2.2	3.3	5.7	1.1	2.4	2.1	2.2	0.1
Number of live births	0.4	0.5	1.0	0.8	-1.0	-0.0	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	-0.1	0.4	-0.4	0.0	0.3
Pulse rate	1.0	1.7	6.3	-1.3	-0.4	-0.1	-0.8	2.5
Happiness	2.0	2.4	5.7	-0.6	-2.1	-1.2	-2.4	0.0
Noisy workplace	0.3	0.3	1.0	-0.0	-0.3	0.4	-0.6	1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.8	0.7	0.8	-0.0	0.9	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.8	-0.7	-1.3	-0.2	-0.9	0.0
Mouth/teeth dental problems: Dentures	0.2	0.3	1.2	1.1	-0.3	-0.3	-0.1	0.1
Asthma	0.3	0.6	1.0	0.9	0.2	1.0	0.6	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.4	0.0	-0.8	-0.0	-0.9	-1.6
Medication: Cholesterol lowering	4.0	6.3	12.8	1.8	3.6	1.7	3.5	0.4
Depression (self-reported)	0.6	0.7	1.6	-0.9	-1.2	-0.7	-0.8	-0.1
Medication: Lansoprazole	0.6	0.7	1.3	1.1	1.0	0.2	0.9	-0.3
Prospective memory result	1.2	1.5	3.6	-0.0	-1.9	-0.6	-1.8	0.5
Lung cancer (father)	1.0	1.2	1.8	1.0	0.9	0.8	1.2	-1.3
Illnesses of mother	0.7	0.8	2.0	-1.4	-0.7	-1.0	-0.5	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	-0.4	-0.4	-0.3	-0.7	-0.6
Pulse wave Arterial Stiffness index	1.0	1.1	2.1	0.5	1.2	1.4	1.3	-0.2
Impedance of arm (left)	0.2	0.8	3.6	-0.4	-0.0	0.5	-0.1	1.9
Arm fat mass (right)	0.8	3.2	4.1	-2.0	-1.9	-1.7	-1.6	1.6
Trunk predicted mass	0.2	1.0	1.6	-1.2	-1.2	-0.8	-1.2	-0.1
Standing height	0.1	1.1	1.9	-1.4	-0.5	0.1	-1.2	1.3
Length of working week for main job	0.6	0.6	1.0	0.9	0.6	0.8	0.4	-1.0
Exposure to tobacco smoke at home	1.8	2.0	4.2	1.1	1.3	2.0	1.1	1.4
Breastfed as a baby	1.9	2.3	3.6	1.4	1.6	0.5	1.8	-1.9
Tense / ‘highly strung’	0.5	0.8	1.9	0.0	-1.4	-0.1	-1.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.5	0.7	0.0	0.1	0.0	-0.5
Hair/balding pattern: Pattern 4	0.1	0.4	1.1	0.4	0.5	0.5	-0.1	-1.1
Birth weight of first child	1.0	1.9	3.5	-1.1	-1.9	-1.0	-1.7	-0.8
Peak expiratory flow (PEF)	0.1	0.2	0.6	-0.2	0.4	-0.4	0.2	0.8
Pulse wave reflection index	2.3	2.9	4.3	1.6	1.5	1.2	1.9	-2.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	0.3	-0.7	-0.6	-0.8	-0.5
Loud music exposure frequency	0.6	0.6	1.8	1.3	-0.0	0.4	0.0	1.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.4	0.2	0.2	0.5	0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	0.0	-1.1	-0.5	-0.8	-0.0
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.3	-0.5	-0.4	-0.6	-0.8
Medication: Paracetamol	0.8	1.4	3.6	1.9	0.8	0.9	0.7	-1.0
Headache pain in last month	0.1	0.2	0.7	0.8	-0.3	0.5	-0.1	0.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.7	-0.7	-1.5	-0.4	-1.6	0.4
Glaucoma (self-reported)	1.3	1.5	2.7	1.6	1.1	1.4	1.0	-0.9
Gout (self-reported)	0.1	0.1	0.3	0.6	-0.0	0.5	0.0	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	0.1	-0.2	0.8	-0.3	-1.0
Medication: Amlodipine	0.9	1.3	2.4	1.1	0.8	0.5	1.3	-1.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.1	-0.2	-0.4	0.0	0.6
Birth weight	0.1	0.3	0.9	-0.6	-0.1	-0.3	-0.4	-1.0
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.7	1.1	-0.2	0.9	0.4	-1.3
High blood pressure (siblings)	2.2	3.1	5.8	2.0	1.2	1.5	1.6	-2.4
Forced vital capacity (FVC), Best measure	0.1	0.3	1.0	0.1	-0.3	0.1	-0.7	-1.0
Body fat percentage	0.4	1.7	4.9	-1.3	-0.7	-1.0	-0.5	2.2
Leg fat percentage (right)	0.2	0.6	1.5	-0.6	-0.4	-0.9	-0.1	1.2
Arm fat-free mass (right)	0.4	1.8	2.7	-1.6	-1.5	-1.4	-1.6	-0.1
Exposure to tobacco smoke outside home	0.3	0.3	0.6	-0.6	0.7	0.1	0.6	0.8
Comparative body size at age 10	0.3	0.7	1.1	-0.3	-1.1	-0.9	-1.0	0.7
Number of full brothers	0.7	0.8	1.3	1.1	0.9	0.7	1.0	-0.7
Worry too long after embarrassment	0.7	1.2	2.9	1.3	0.7	1.7	0.9	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	2.8	1.7	0.1	0.8	0.3	-1.1
Wheeze or whistling in the chest in last year	0.7	1.2	1.9	-0.8	-1.4	-0.7	-1.1	1.4
Number of children fathered	1.2	1.3	1.7	1.2	1.3	1.2	1.3	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.2	0.1	1.0	0.6	1.1	-0.3
Age at first live birth	0.1	0.1	0.2	0.4	0.4	-0.1	0.3	-0.3
Pulse wave peak to peak time	1.1	1.3	2.3	-0.6	-1.3	-1.5	-1.5	0.3
Health satisfaction	0.5	0.6	1.5	1.2	0.3	0.4	0.7	0.8
Shortness of breath walking on level ground	1.0	1.2	3.5	1.2	0.5	1.9	0.6	0.7
Qualifications: College or University degree	0.1	0.3	1.4	-0.1	0.4	0.0	0.2	1.2
Eye problems/disorders: None of the above	0.2	0.2	0.7	0.4	0.1	0.0	0.3	-0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.8	-0.2	-0.7	-0.8	-0.7	0.9
Emphysema/chronic bronchitis	0.3	0.4	0.8	0.9	-0.6	-0.0	-0.8	0.0
Medication for pain relief, constipation, heartburn	0.3	0.6	1.0	-0.9	0.5	-0.5	0.7	1.0
Neck or shoulder pain in last month	2.7	3.8	5.2	2.3	2.2	2.0	1.8	-1.3
Medication: Blood pressure	0.6	1.0	4.0	0.8	0.2	0.4	0.5	-2.0
Angina (self-reported)	1.6	2.2	4.9	1.1	1.6	2.2	1.3	0.8
Migraine (self-reported)	0.4	0.4	1.6	0.7	0.0	0.3	0.0	-1.3
Medication: Ibuprofen	1.0	1.1	3.2	0.4	-1.1	-0.2	-1.1	-1.8
Medication: Allopurinol	0.1	0.1	0.1	0.4	-0.3	-0.1	-0.3	0.2
Medication: Omeprazole	0.0	0.1	0.2	0.1	0.0	-0.5	0.0	-0.2
Medication: Seretide 50 evohaler	0.9	1.0	3.3	-0.9	-0.6	-0.3	-0.8	1.8
Mean time to correctly identify matches	1.1	2.1	3.6	-1.8	-1.9	-0.8	-1.7	0.6
Heart disease (mother)	0.4	0.5	1.9	1.4	0.6	0.4	0.5	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.5	1.1	0.3	0.2	0.5	-1.2
Whole body fat mass	0.5	2.0	3.7	-1.7	-1.2	-1.1	-1.0	1.9
Leg fat mass (right)	0.3	1.3	2.4	-1.3	-0.9	-1.1	-0.7	1.6
Arm predicted mass (right)	0.2	1.1	1.9	-1.4	-1.0	-1.1	-1.2	0.1
Pulse rate, automated reading	0.3	0.8	1.9	-1.4	-0.7	-1.1	-0.6	0.4
Alcohol intake frequency.	1.0	2.3	4.6	-2.0	-1.1	-0.3	-1.3	2.1
Comparative height size at age 10	0.4	2.1	4.2	-1.4	-1.2	-0.5	-1.7	2.1
Number of full sisters	0.4	0.4	0.9	-0.9	-0.8	-0.2	-0.7	0.3
Suffer from ‘nerves’	0.7	1.1	2.2	-0.1	-1.2	-0.5	-1.2	1.5
Overall health rating	0.4	1.0	1.9	-0.4	-1.2	-0.8	-0.8	1.4
Chest pain or discomfort	0.3	0.5	1.2	0.6	0.3	1.1	0.5	0.8
Had major operations	0.3	0.4	0.7	-0.2	0.8	-0.6	0.5	0.8
Age at last live birth	0.2	0.3	0.6	0.8	-0.5	-0.0	-0.4	-0.7
Family relationship satisfaction	1.7	2.1	2.8	0.9	1.5	1.7	1.4	1.6
Leg pain on walking	0.4	0.5	1.2	1.1	0.4	-0.1	0.3	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.0	-0.4	-1.4	-0.3	-1.3	-0.4
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.1	-0.3	0.2	-0.3	0.1	1.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.5	-1.2	-0.9	-0.6	-1.1	0.7
Medication: Aspirin	0.9	1.1	3.0	1.1	0.9	1.7	0.7	0.2
Supplements: Vitamin C	0.5	0.6	1.3	-0.5	0.9	1.1	0.6	0.4
Knee pain experienced in last month	2.0	3.2	7.4	-1.0	-1.9	-2.7	-1.5	-1.2
Hypertension (Self-reported)	1.7	4.8	7.6	2.8	1.7	2.5	2.0	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.5	-0.0	-0.1	0.0	-0.2	-0.7
Illnesses of father: Heart disease	0.9	1.3	3.0	0.9	1.2	1.7	1.0	0.5
Illnesses of siblings: Diabetes	2.0	2.5	4.1	1.3	1.7	1.7	2.0	1.1
Smoking status: Previous	0.9	1.4	3.4	1.8	0.9	0.7	1.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.1	-1.2	-0.4	-1.4	-0.3	0.9
Whole body fat-free mass	0.3	1.9	2.8	-1.7	-1.7	-1.2	-1.7	0.1
Leg fat-free mass (right)	0.6	3.2	4.6	-2.1	-2.1	-1.6	-2.1	0.2
Arm fat percentage (left)	0.5	2.1	2.7	-1.6	-1.4	-1.6	-0.9	1.6
Average weekly red wine intake	1.9	2.8	6.5	0.9	2.5	0.7	2.4	0.4
Handedness (chirality/laterality): Left-handed	0.5	0.7	1.5	1.2	0.4	1.0	0.3	-0.8
Mood swings	2.7	4.9	9.3	-1.9	-2.9	-1.7	-3.0	0.6
Loneliness, isolation	0.5	0.6	2.2	0.4	-0.6	0.7	-0.1	1.5
Long-standing illness, disability or infirmity	0.2	0.3	0.8	-0.4	-0.3	-0.8	0.1	0.9
Ever had bowel cancer screening	1.2	1.4	2.9	0.8	0.6	1.7	0.8	-1.6
Diabetes diagnosed by doctor	0.3	0.4	0.6	0.1	0.8	0.8	0.7	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.1	1.1	-0.2	-0.5	-0.1	-0.9
Friendships satisfaction	1.8	2.2	3.4	1.6	1.8	1.2	1.9	0.7
Qualifications: nursing, teaching	0.2	0.4	0.7	0.8	0.6	0.6	0.6	0.2
Commuting to job workplace: Walk	0.6	0.6	1.1	-0.8	-1.1	0.6	-1.0	-0.3
Eye problems/disorders: Cataract	0.2	0.2	0.8	0.3	0.3	0.3	0.1	0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.0	0.4	-1.3	-0.9	-1.4	-1.2
Medication for cholesterol	6.0	9.1	12.1	-3.5	-2.7	-3.4	-3.0	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	0.8	-0.7	1.0	-0.4	0.0
Back pain experienced in last month	0.1	0.2	0.4	0.3	-0.6	-0.2	-0.6	0.2
Mineral and other dietary supplements	1.0	1.4	2.8	1.7	1.3	0.7	1.2	0.5
Breast cancer (self-reported)	1.2	1.4	3.7	-1.0	-0.6	-1.3	-0.4	1.9
Asthma (self-reported)	0.3	0.6	0.9	0.9	0.3	0.9	0.7	0.7
Osteoporosis (self-reported)	0.2	0.2	0.3	0.6	-0.0	0.6	0.3	-0.4
Osteoarthritis (self-reported)	0.3	0.4	1.2	0.8	0.3	-0.4	0.4	-1.1
Medication: Aspirin	0.7	1.0	3.2	1.1	0.7	1.8	0.3	-0.0
Medication: Gliclazide	1.0	1.1	1.5	1.1	1.2	1.2	1.1	0.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.4	-1.2	-0.2	-1.1	-0.3	-0.5
Smoking status: Current	0.1	0.2	0.5	-0.1	-0.5	-0.7	-0.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.1	-0.0	-1.0	-0.6	-1.0	-1.4
Whole body water mass	0.3	2.0	2.9	-1.6	-1.7	-1.2	-1.7	0.1
Leg predicted mass (right)	0.6	3.1	4.5	-2.1	-2.1	-1.5	-2.1	0.2
Arm fat mass (left)	0.7	2.7	3.6	-1.9	-1.7	-1.6	-1.4	1.6
Number of self-reported non-cancer illnesses	0.3	0.6	1.3	1.1	-0.4	0.4	-0.5	-1.1
Average weekly champagne plus white wine intake	1.8	2.5	5.2	2.3	1.5	1.5	1.6	-0.2
Miserableness	1.4	2.5	5.9	-0.3	-2.4	-1.0	-2.3	-0.2
Guilty feelings	0.7	1.1	2.0	-0.9	-1.4	-1.1	-1.2	-0.0
Wears glasses or contact lenses	0.1	0.2	0.4	-0.7	-0.1	0.5	0.2	-0.1
Ever taken oral contraceptive pill	0.5	0.6	1.3	-0.1	1.0	0.2	0.8	1.1
Hearing aid user	1.4	1.6	2.9	1.1	1.6	1.2	1.7	0.2
Mother’s age at death	0.4	0.5	1.3	0.1	0.8	0.1	0.5	1.2
Financial situation satisfaction	0.4	0.5	1.1	0.5	-0.5	-1.1	-0.4	-0.9
Tinnitus: Yes, now most or all of the time	0.5	0.5	2.5	0.1	-0.0	-0.3	-0.0	-1.6
Commuting to job workplace: Public transport	0.3	0.3	0.6	0.5	0.7	0.2	0.8	-0.3
Eye problems/disorders: Glaucoma	0.3	0.4	1.1	0.6	0.5	1.1	0.3	-0.1
Medication: Blood pressure	1.0	1.8	3.3	1.7	0.3	1.8	0.8	-1.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.0	1.0	0.1	0.2	0.3	-1.4
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.1	-0.9	-1.0	-1.0	-0.7	-0.8
High cholesterol (Self-reported)	6.0	10.7	18.9	3.0	4.0	3.0	4.3	-0.2
Medication: Bendroflumethiazide	0.5	0.8	3.0	0.6	0.3	0.6	0.4	-1.7
Medication: Paracetamol	0.4	0.6	1.9	1.4	0.1	0.5	-0.1	-0.8
Medication: Lisinopril	1.2	1.6	2.6	-1.2	-1.6	-1.1	-1.5	-0.5
Medication: Atorvastatin	3.5	4.3	7.7	2.0	2.1	2.8	1.9	1.3
Illnesses of father: High blood pressure	0.8	1.0	1.5	1.0	-1.0	0.7	-1.0	-1.2
Alcohol drinker status: Never	0.4	0.5	1.9	-0.2	0.4	-0.5	0.6	1.4
Ever smoked	0.2	0.4	0.8	0.9	-0.0	-0.3	0.5	-0.9
Basal metabolic rate	0.4	1.9	2.9	-1.7	-1.6	-1.2	-1.6	0.4
Leg fat percentage (left)	0.2	0.9	1.7	-0.9	-0.6	-1.2	-0.3	1.3
Arm fat-free mass (left)	0.3	1.6	2.4	-1.5	-1.4	-1.2	-1.5	0.2
Number of operations (self-reported)	0.3	0.4	0.9	-0.2	0.4	-0.7	0.7	0.9
Average weekly beer plus cider intake	0.3	0.4	1.6	-0.7	-0.3	-1.3	-0.2	0.2
Irritability	0.3	0.5	1.5	0.5	-0.5	0.4	-0.5	1.2
Risk taking	0.4	0.5	1.4	0.1	0.8	0.1	1.2	0.8
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.5	-1.2	-0.4	0.1	-0.5	-0.1
Fractured/broken bones in last 5 years	1.5	1.9	4.0	-1.0	-1.5	-2.0	-1.5	-0.2
Age started oral contraceptive pill	1.6	2.1	3.8	-1.9	-1.2	-1.1	-1.5	1.2
Diastolic blood pressure, automated reading	1.0	3.2	4.5	2.0	2.1	1.8	2.0	-0.5
Ever depressed for a whole week	0.9	1.1	2.3	-0.3	-1.5	-0.4	-1.4	-0.9
Unable to work because of sickness or disability	1.0	1.2	2.5	-0.3	-1.6	-1.5	-1.1	-0.4
Commuting to job workplace: Cycle	0.6	0.7	1.2	1.0	0.7	0.7	0.6	-1.1
Myopia	0.1	0.1	0.1	-0.4	-0.3	0.1	-0.4	-0.0
Vascular/heart problems diagnosed by doctor	2.4	6.7	9.9	-3.1	-2.3	-3.1	-2.7	1.2
Cholesterol lowering medication	4.6	6.8	9.4	2.6	3.1	3.0	2.9	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	0.2	-0.5	-0.8	-0.4	-0.2
Pain experienced in last month	0.2	0.3	0.5	-0.7	0.5	0.3	0.3	0.7
Supplements: Calcium	1.3	1.4	3.0	-1.7	0.8	0.8	0.8	1.5
Basal cell carcinoma (self-reported)	0.4	0.4	1.2	-0.5	-0.4	-0.4	-0.6	-1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.1	0.5	1.1	0.9	0.7	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.7	0.0	-0.4	-0.2	-0.5	-0.8
Heart disease (siblings)	0.5	0.7	2.0	0.2	-1.4	-0.6	-0.8	-0.5
Alcohol drinker status: Previous	0.6	0.7	2.1	-1.5	-0.0	-0.0	-0.3	1.1
Pack years of smoking	1.0	1.5	2.8	-1.0	-1.3	-0.9	-1.1	1.7
Impedance of whole body	0.3	1.5	3.7	0.5	1.2	1.1	0.9	1.9
Leg fat mass (left)	0.4	1.5	2.1	-1.5	-1.1	-1.3	-0.9	1.4
Arm predicted mass (left)	0.5	2.3	3.6	-1.7	-1.7	-1.3	-1.9	0.5