Hub : Genes

RP11-517P14.2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1390	0.0400	1.4e-05	0.090	NA	0.066	NA	0.061	8.3e-08	NA	4.4e-06	NA	1.0e-05
2	GTEx	Adrenal Gland	0.2153	0.0817	8.9e-03	0.032	NA	0.026	NA	0.033	2.5e-02	NA	3.9e-02	NA	2.4e-02
3	GTEx	Artery Aorta	0.2740	0.0590	4.5e-07	0.136	NA	0.166	NA	0.187	6.0e-08	NA	1.9e-09	NA	1.4e-10
4	GTEx	Artery Tibial	0.1757	0.0546	7.1e-04	0.083	NA	0.079	NA	0.102	4.4e-07	NA	8.4e-07	NA	2.2e-08
5	GTEx	Brain Frontal Cortex BA9	0.4482	0.1135	5.6e-04	0.031	NA	0.124	NA	0.154	5.1e-02	NA	3.6e-04	NA	7.2e-05
6	GTEx	Cells EBV-transformed lymphocytes	0.4480	0.1090	5.5e-04	0.084	NA	0.232	NA	0.203	1.1e-03	NA	4.1e-08	NA	3.2e-07
7	GTEx	Cells Transformed fibroblasts	0.2680	0.0560	4.6e-09	0.209	NA	0.225	NA	0.230	1.3e-15	NA	7.4e-17	NA	3.0e-17
8	GTEx	Colon Transverse	0.1900	0.0600	3.1e-04	0.179	NA	0.173	NA	0.186	6.4e-09	NA	1.2e-08	NA	3.2e-09
9	GTEx	Esophagus Mucosa	0.1520	0.0510	1.5e-03	0.083	NA	0.038	NA	0.046	3.4e-06	NA	1.3e-03	NA	4.9e-04
10	GTEx	Esophagus Muscularis	0.2330	0.0600	6.3e-05	0.040	NA	0.068	NA	0.074	1.7e-03	NA	6.3e-05	NA	2.7e-05
11	GTEx	Heart Atrial Appendage	0.1990	0.0620	6.8e-04	0.122	NA	0.092	NA	0.125	4.1e-06	NA	6.5e-05	NA	3.0e-06
12	GTEx	Lung	0.1431	0.0486	2.5e-03	0.090	NA	0.081	NA	0.078	2.1e-07	NA	8.8e-07	NA	1.3e-06
13	GTEx	Muscle Skeletal	0.2079	0.0526	9.5e-07	0.099	NA	0.117	NA	0.127	5.6e-10	NA	1.6e-11	NA	1.9e-12
14	GTEx	Skin Not Sun Exposed Suprapubic	0.1070	0.0470	6.5e-03	0.012	NA	0.004	NA	0.087	7.1e-02	NA	1.8e-01	NA	1.6e-05
15	GTEx	Skin Sun Exposed Lower leg	0.1410	0.0380	5.3e-06	0.118	NA	0.090	NA	0.110	5.2e-10	NA	6.8e-08	NA	2.4e-09
16	GTEx	Stomach	0.2610	0.0690	1.6e-04	0.085	NA	0.035	NA	0.098	7.1e-05	NA	8.7e-03	NA	2.1e-05
17	GTEx	Thyroid	0.1160	0.0440	2.7e-03	0.073	NA	0.040	NA	0.056	2.8e-06	NA	4.6e-04	NA	4.3e-05
18	METSIM	Adipose	0.0701	0.0215	1.2e-05	0.043	0.024	0.046	0.04	0.047	3.9e-07	0.00015	1.8e-07	1.1e-06	1.1e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Bipolar Disorder (2018)	0.5	0.8	2.8	0.6	0.6	1.3	1.7	0.1	0.4	0.0	1.2	0.9	0.7	-0.4	0.6	0.0	1.3	1.4	0.2	1.2	0.7
Bipolar Disorder or Schizophrenia	0.1	0.2	1.1	0.3	1.1	0.3	0.3	0.1	0.0	0.0	0.2	0.2	0.2	-0.1	-0.6	-0.1	0.3	0.8	-0.0	0.5	0.4
Depressed Affect (Nagel 2018)	0.6	1.3	4.0	-1.0	-1.0	-0.7	-1.0	-2.0	-1.0	-0.7	-0.7	-1.6	-1.5	-0.1	-1.0	-0.9	-1.6	-1.1	-1.0	-1.6	-0.6
Depression (Nagel 2018)	1.2	1.8	7.1	0.5	-1.6	-0.6	-0.8	-2.7	-1.8	-2.0	-0.9	-1.1	-1.6	-0.9	-1.1	-1.3	-0.7	-0.5	-0.9	-1.7	1.1
Intelligence (Savage-Jansen 2018)	0.4	1.1	4.6	0.9	1.0	-1.3	-0.7	-1.3	-1.7	-2.1	-0.6	-0.5	-0.7	-1.0	0.0	-0.9	0.1	1.0	-0.7	-0.6	1.4
Neuroticism (Nagel 2018)	0.8	1.8	5.1	-1.7	-1.6	-0.3	-1.0	-1.1	0.1	0.0	-1.1	-1.6	-1.3	1.4	-1.0	0.2	-2.3	-2.1	0.1	-1.9	-1.7
Schizophrenia (2018)	0.1	0.3	1.5	-0.0	0.8	-0.7	-0.9	-0.0	-0.3	-0.0	-0.7	-0.4	-0.2	0.2	-1.2	-0.1	-0.6	-0.1	-0.1	-0.3	-0.1
Schizophrenia vs Biploar Disorder	0.4	0.6	2.7	1.0	1.6	-0.4	-0.4	-0.5	-0.6	-1.0	-0.1	0.4	0.5	0.1	0.0	-0.3	0.4	1.4	0.3	0.3	1.2
Worry (Nagel 2018)	1.4	2.9	7.2	-2.0	-2.1	-0.8	-1.4	-0.6	0.1	-0.0	-2.0	-1.9	-1.5	1.9	-1.5	0.1	-2.6	-2.6	0.5	-2.7	-2.0
Alzheimer’s Disease (in mother)	0.2	0.2	1.0	-0.3	1.0	-0.2	0.5	0.5	0.3	0.7	0.6	0.2	0.3	-0.1	0.0	-0.2	0.3	0.4	-0.2	0.5	0.0
Alzheimer’s Disease (in father)	0.2	0.3	0.8	-0.9	0.2	-0.4	-0.6	0.7	0.0	0.5	-0.1	-0.4	-0.2	0.5	0.8	-0.4	-0.6	-0.7	-0.1	-0.3	-0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	1.2	-1.1	0.7	-0.6	-0.2	0.9	0.3	0.8	-0.0	-0.3	0.0	0.6	0.1	-0.3	-0.5	-0.5	0.1	-0.1	-0.6
Crohns Disease (2017)	1.5	3.3	14.9	0.7	-1.4	-0.5	0.1	-3.9	-2.0	-3.2	-0.9	-1.0	-1.7	-2.6	-1.3	-2.3	0.1	0.6	-1.2	-1.7	1.9
Irritable Bowel Disease (IBD)	1.0	2.3	11.4	0.6	-0.0	-0.2	0.3	-3.4	-1.6	-2.6	-0.8	-0.7	-1.3	-2.2	-1.1	-1.9	0.3	1.0	-1.1	-1.1	1.9
Ulcerative Colitis (UC)	0.2	0.5	2.1	-0.1	0.7	-0.2	-0.0	-1.4	-0.5	-1.0	-0.8	-0.5	-0.7	-0.8	-0.9	-0.8	-0.1	0.3	-0.6	-0.5	0.6
Major Depression (MDD)	2.1	2.6	9.8	1.5	3.1	0.7	1.6	-0.2	-0.0	-0.3	2.0	2.0	1.5	-0.9	0.9	0.2	2.2	2.5	-0.1	2.3	1.6
Reaction Time	0.4	0.8	1.9	0.2	0.8	1.1	1.3	-0.1	0.7	0.1	1.1	1.4	1.2	0.6	0.4	0.6	1.1	1.1	1.0	0.9	0.6
Verbal and Numeric Reasoning (VNR)	1.1	2.7	7.0	0.3	0.6	-2.5	-1.6	-1.9	-2.5	-2.6	-1.7	-1.4	-1.7	-1.8	-1.0	-1.9	-0.6	0.4	-1.6	-1.5	1.5
Breast Cancer	0.1	0.3	1.0	0.7	0.5	-0.3	-0.1	0.1	0.0	-0.5	0.7	0.7	0.7	0.7	-0.3	0.7	0.4	0.5	1.0	0.1	0.7
Ovarian Cancer	0.7	1.0	1.8	1.3	0.7	0.9	1.1	0.4	0.5	0.0	0.9	1.1	1.1	0.7	1.3	1.2	1.0	1.1	1.3	1.0	0.7
Prostate Cancer	0.9	1.3	3.3	-1.6	1.2	-1.0	-1.3	-0.2	-0.5	0.2	-1.8	-1.8	-1.2	-0.1	-0.5	-0.3	-1.8	-1.0	-0.9	-1.1	-1.1
Age at First Birth	0.4	0.6	1.7	-0.1	-0.2	-1.1	-1.3	-0.5	-0.7	-0.5	-0.6	-1.2	-0.9	-0.3	-0.5	-1.2	-0.9	-0.7	-0.8	-0.7	-0.2
Bipolar Disorder (2011)	2.4	2.3	4.9	0.8	1.5	2.2	2.2	1.2	1.7	1.3	1.7	1.7	1.8	1.0	1.6	1.2	1.4	1.1	1.5	2.0	-0.2
Body Mass Index (BMI) (2010)	0.9	1.2	3.8	-0.7	0.1	-2.0	-1.6	-0.3	-1.1	-0.7	-1.4	-1.4	-1.2	-0.5	-1.5	-0.7	-1.3	-0.9	-1.0	-1.2	-0.2
Coronary Artery Disease (CAD)	0.9	1.1	4.1	1.2	1.7	-0.2	-0.0	-1.5	-1.2	-1.6	-0.2	0.1	0.1	-1.1	0.3	-1.1	0.7	1.4	-0.1	0.2	2.0
Crohns Disease (2012)	0.7	1.2	3.5	1.1	0.5	0.5	1.0	-1.9	-0.8	-1.8	0.7	0.7	0.3	-1.2	-0.1	-0.5	1.1	1.8	0.3	0.3	1.9
Mean Putamen Volume	0.7	0.8	3.2	-1.3	-1.8	-0.0	-0.5	0.1	0.2	-0.2	-1.6	-0.7	-0.6	0.2	-1.0	-0.5	-0.9	-1.4	-0.0	-1.1	-0.9
Fasting Glucose	1.3	1.6	4.5	-2.1	-0.3	-1.7	-1.8	1.0	-0.0	0.5	-1.1	-1.3	-0.7	0.9	-0.8	0.1	-1.7	-1.8	-0.6	-1.3	-1.8
HbA1C	0.4	0.5	2.3	-0.4	-0.3	0.1	-0.2	1.5	0.8	-0.3	-0.2	0.2	0.6	0.9	0.7	1.2	-0.3	-0.6	0.4	-0.0	-1.1
HDL Cholesterol	0.8	1.4	4.1	2.0	-0.7	0.9	1.7	-1.4	-0.6	-0.7	1.6	1.1	0.3	-1.1	1.0	-0.4	1.7	1.3	-0.4	1.0	1.4
LDL Cholesterol	0.6	0.9	2.7	0.5	1.4	0.9	0.7	1.1	1.1	0.4	0.6	1.2	1.4	1.0	0.8	1.3	0.5	0.7	1.6	0.5	0.0
Lupus	0.1	0.1	0.8	0.3	0.9	-0.5	-0.1	0.1	-0.4	0.1	0.1	0.1	-0.0	-0.2	0.7	-0.1	0.2	0.4	-0.2	0.4	0.3
Neuroticism (2016)	0.2	0.3	0.8	-0.6	-0.3	-0.2	-0.1	-0.7	-0.6	-0.4	-0.6	-0.8	-0.8	-0.7	-0.2	-0.3	-0.4	-0.2	-0.9	-0.4	-0.3
Primary Biliary Cirrhosis	0.7	1.0	2.5	0.6	1.6	1.0	1.4	-0.4	0.3	0.4	1.1	1.0	0.8	-0.7	1.4	0.1	1.2	1.6	-0.3	1.6	0.7
Rheumatoid Arthritis	0.3	0.4	1.0	0.7	-1.0	-0.9	-0.5	-1.0	-0.9	-1.0	-0.2	-0.2	-0.4	-0.6	-0.7	-0.5	0.1	0.2	-0.5	-0.3	0.8
Schizophrenia (2014)	0.5	1.1	4.0	1.7	1.2	-0.6	0.1	-0.8	-1.2	-1.1	0.2	0.7	0.3	-0.9	-0.4	-0.7	1.2	1.8	-0.4	0.8	2.0
Triglycerides	0.3	0.5	2.0	-0.7	1.4	-1.3	-1.3	0.4	-0.4	-0.4	-1.1	-0.6	-0.2	0.3	-0.3	-0.1	-0.7	-0.2	0.2	-0.5	0.1
Type 2 Diabetes (T2D) (2012)	4.2	4.9	11.3	-0.5	1.2	3.4	1.9	2.5	3.2	2.7	1.5	2.0	2.9	2.8	1.1	3.1	0.6	0.1	3.0	1.5	-1.6
Ulcerative Colitis	0.4	0.6	6.6	-0.1	2.6	-0.4	-0.6	-0.5	-0.5	-0.5	-0.8	-0.4	-0.4	-0.1	-0.1	-0.6	-0.3	0.7	-0.4	-0.2	0.5
Blood Eosinophil Count	1.0	8.0	29.8	3.8	4.3	0.0	1.2	-3.2	-2.2	-3.9	0.3	1.7	1.0	-2.3	0.7	-1.1	3.1	5.1	0.2	1.3	5.5
Blood Platelet Count	0.6	7.2	18.5	-3.2	-2.8	0.2	-2.0	1.8	2.4	1.4	-2.2	-1.6	-0.4	3.7	-2.5	2.0	-3.8	-4.3	2.9	-2.9	-3.9
Blood Red Count	0.5	5.1	13.8	3.0	-0.7	-0.6	1.2	-3.4	-2.9	-3.2	0.3	0.7	-0.7	-3.6	-0.8	-2.6	2.4	2.3	-1.9	0.6	3.7
Blood White Count	0.0	0.2	0.9	-0.9	-0.8	0.5	0.1	-0.3	0.2	-0.1	-0.9	-0.2	-0.2	-0.4	0.0	-0.3	-0.2	-0.4	0.1	-0.5	-0.1
Heel T-Score	2.5	20.0	37.8	6.2	4.9	4.4	5.2	0.7	2.3	0.5	6.0	5.5	5.1	1.2	5.1	3.2	5.6	5.6	3.3	5.4	3.6
BMI	0.2	1.2	4.5	-0.6	-0.3	1.2	0.6	2.0	1.5	2.1	0.8	0.8	1.1	0.9	0.2	1.1	0.3	-0.9	0.6	1.0	-1.3
Height	0.5	8.7	25.5	3.3	0.7	-3.0	0.2	-3.2	-4.3	-3.6	0.3	0.4	-1.1	-5.0	-0.3	-3.5	2.8	3.3	-3.7	1.1	4.6
Waist Hip Ratio (WHR)	0.3	1.3	3.0	1.7	0.9	-0.4	0.3	-0.1	-0.9	-0.2	1.2	0.7	0.3	-1.4	1.7	-1.3	1.4	1.5	-1.2	1.4	1.4
Systolic Blood Pressure	0.3	1.3	2.8	-0.2	-1.5	1.4	1.0	1.4	1.6	1.2	0.4	1.0	1.0	1.2	0.9	1.7	0.2	-1.0	1.6	0.4	-1.3
Smoking Status	0.1	0.1	0.6	0.8	-0.3	0.0	0.3	-0.0	-0.2	0.4	0.4	0.0	-0.1	-0.5	0.3	-0.1	0.4	0.0	-0.7	0.5	-0.1
Allergy or Eczema	0.9	2.5	6.2	1.7	1.2	0.7	0.9	-0.1	0.4	-0.8	1.0	2.2	2.2	0.8	1.6	1.3	2.0	2.5	2.0	1.7	2.5
Cardiovascular Disease	0.3	1.0	3.6	0.3	-1.9	1.8	1.6	0.6	0.9	0.6	1.1	1.3	0.9	-0.2	0.7	0.7	1.2	-0.0	0.4	1.2	-0.0
Hypothyroidism (self reported)	0.6	1.4	3.7	-0.0	-0.5	1.9	1.4	1.4	1.6	1.7	1.6	1.3	1.1	0.8	0.7	1.3	0.8	-0.3	0.8	1.3	-0.9
Respiratory disease	1.3	2.9	5.3	1.3	2.0	2.2	2.0	0.3	1.6	0.5	1.5	1.9	2.3	0.9	1.5	1.9	1.6	2.0	2.3	1.9	0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.5	-0.6	1.2	0.0	-0.9	0.7	0.4	0.6	-0.8	-0.2	0.3	0.8	-0.7	-0.1	-0.7	-0.0	0.7	-0.2	-0.2
Lung FEV1/FVC ratio	0.2	0.9	2.3	-0.8	1.0	0.9	0.0	1.5	1.4	1.4	0.7	0.5	1.0	1.3	0.8	0.8	-0.1	-0.2	0.8	0.8	-0.9
Lung FVC	0.3	1.7	5.0	-0.6	-1.2	-1.1	-1.5	-1.6	-1.4	-2.2	-1.5	-1.3	-1.6	-0.3	-1.2	-0.9	-1.3	-1.1	-0.1	-2.2	0.3
Neuroticism	0.8	2.0	4.7	-1.6	-1.2	-1.1	-1.6	-1.5	-0.9	-0.5	-1.6	-1.9	-1.9	0.2	-1.1	-0.8	-2.2	-1.6	-1.1	-1.9	-1.1
Chronotype (morning person)	1.3	2.9	8.6	2.3	2.4	0.5	1.8	-0.8	-0.7	-1.0	1.3	1.6	1.1	-1.6	1.7	-0.7	2.4	2.9	-0.5	2.0	2.4
Hair Pigment	0.0	1.4	6.9	-0.2	0.8	0.8	-0.7	0.5	1.3	-0.9	-0.6	-0.1	0.9	2.5	-0.8	1.7	-1.1	0.0	2.6	-0.5	-0.5
Tanning	0.1	0.7	2.3	1.5	0.5	0.4	1.1	0.2	0.3	0.0	1.2	0.9	0.6	-0.9	0.7	-0.3	1.4	1.1	-0.6	1.2	0.5
Hand grip strength (left)	0.1	0.3	1.8	-0.2	0.5	-0.8	-0.2	1.3	0.2	0.8	0.2	0.3	0.4	-0.1	-0.5	0.1	0.1	-0.1	-0.2	0.5	-0.5
Number of treatments/medications taken	0.4	0.8	3.3	0.8	-0.3	0.0	0.8	-1.3	-1.1	-0.3	0.8	-0.3	-0.9	-1.7	0.4	-1.1	0.6	0.4	-1.8	0.3	0.4
Average weekly spirits intake	0.8	1.0	2.8	0.6	1.4	1.0	0.7	0.7	1.0	0.5	0.6	1.0	1.3	1.3	0.9	1.7	0.4	0.5	1.5	0.9	-0.1
Sensitivity / hurt feelings	1.5	2.5	5.3	0.8	2.2	1.3	1.7	0.6	1.2	1.4	2.1	1.9	1.9	1.0	2.3	1.6	1.5	1.7	1.0	2.3	0.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.1	-0.5	-0.8	-0.6	-1.0	-1.3	-1.2	-0.8	-1.1	-1.3	-1.5	-0.9	-0.8	-0.9	-1.1	-0.7	-1.2	-1.3	-0.1
Hearing difficulty/problems: Yes	1.2	1.8	6.0	-1.4	-0.3	0.1	-0.9	1.6	1.2	1.5	-1.3	-0.3	0.5	2.4	-0.4	2.0	-1.3	-1.8	1.7	-0.5	-1.7
Relative age of first facial hair	1.7	3.6	14.2	-1.7	0.5	1.1	-0.0	2.4	2.6	1.9	0.2	0.2	1.4	3.8	0.5	2.5	-1.5	-1.3	3.3	-0.3	-2.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.5	-0.4	0.1	-0.4	0.5	0.0	0.2	-0.1	-0.2	0.2	0.2	0.2	0.1	-0.2	0.1	0.4	-0.0	-0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.3	1.1	0.1	0.8	0.7	-0.6	-0.1	-0.8	0.1	0.4	0.3	0.3	0.4	0.7	0.4	0.3	0.7	0.1	0.2
Ever had hysterectomy (womb removed)	0.4	0.4	1.5	0.3	1.0	0.3	0.4	-0.8	-0.5	-0.5	0.0	-0.3	-0.5	-1.2	-0.4	-0.9	0.3	0.9	-1.0	0.1	0.6
Systolic blood pressure, automated reading	0.5	1.4	4.5	-1.4	-1.8	-0.4	-1.0	0.4	0.4	0.3	-1.0	-0.9	-0.7	1.0	-1.2	0.4	-1.7	-2.1	0.6	-1.5	-1.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.6	-1.0	0.5	0.2	-0.6	0.5	0.8	0.5	-0.4	-0.4	0.3	1.3	-0.9	0.6	-0.9	-0.2	1.1	-0.3	-0.7
Angina	0.7	0.9	2.8	0.1	1.2	0.6	-0.0	1.2	1.1	1.5	0.3	-0.0	0.5	1.1	1.7	1.1	-0.5	-0.5	0.7	0.3	-1.3
Medication for hormone replacement therapy	1.3	1.4	6.1	2.5	-0.0	-0.0	1.3	-0.3	-0.9	-0.1	1.8	1.1	0.4	-1.5	0.9	-0.2	1.8	1.1	-1.2	1.6	0.9
Vitamin and mineral supplements	0.4	0.5	1.7	-0.5	-0.8	0.2	-0.4	0.4	0.7	-0.1	-0.5	-0.2	0.2	1.3	-0.8	0.7	-0.7	-1.2	1.2	-0.6	-0.8
Supplements: Zinc	1.5	1.6	4.4	-0.2	1.0	1.0	1.0	1.9	1.8	2.1	1.0	1.1	1.5	0.8	1.9	1.4	0.5	0.5	0.7	1.6	-1.0
Medication: Co-codamol	0.6	0.7	1.4	-0.3	-0.5	-0.7	-0.6	-1.0	-1.0	-0.8	-1.1	-1.0	-1.2	-0.9	-0.8	-0.9	-0.4	-0.1	-1.1	-0.9	0.4
Medication: Metformin	0.3	0.4	2.3	-0.4	1.5	-0.4	-1.1	0.0	0.2	0.1	-1.1	-0.6	-0.0	0.2	-0.4	-0.3	-0.9	-0.0	0.3	-0.3	-0.0
Diabetes (father)	0.4	0.5	3.1	-1.8	0.8	-0.1	-0.8	0.8	0.4	1.0	-0.9	-0.6	-0.1	0.3	-0.3	0.2	-1.0	-0.5	-0.2	-0.1	-0.9
Diabetes (mother)	1.2	1.6	4.2	2.0	1.4	1.1	1.3	0.1	0.3	-0.5	1.2	1.6	1.4	0.3	1.8	0.7	1.6	1.4	1.2	1.1	1.2
Severe depression (siblings)	0.7	0.8	3.7	-0.1	1.9	0.6	0.5	1.2	0.8	1.2	0.2	0.8	1.1	0.6	1.3	0.4	0.4	0.6	0.7	1.1	-0.2
Pack years adult smoking proportion	0.5	0.8	2.1	1.1	-0.1	-0.8	0.2	-0.2	-0.9	-0.5	1.1	1.1	0.4	-0.7	1.1	-0.9	1.4	1.1	-0.6	1.0	1.4
Impedance of leg (right)	0.2	1.0	3.7	0.6	-1.1	-0.8	-0.7	-1.6	-1.1	-1.9	-1.5	-0.8	-0.9	-0.3	-1.5	-0.2	-0.4	-0.0	0.0	-1.1	0.9
Leg fat-free mass (left)	0.1	0.5	2.8	0.1	0.3	-0.6	0.1	0.2	-0.7	0.4	0.4	0.2	-0.2	-1.7	0.4	-1.2	0.7	0.3	-1.6	0.7	0.4
Trunk fat percentage	0.9	3.5	6.8	-1.7	-2.0	-1.8	-2.1	-0.8	-1.4	-0.3	-2.4	-2.3	-2.3	-1.0	-2.3	-1.3	-2.1	-2.6	-2.0	-2.1	-1.3
Hand grip strength (right)	0.3	0.9	3.5	0.1	1.9	-0.0	0.3	1.9	0.9	1.2	0.7	0.9	1.2	0.6	0.7	1.0	0.4	0.8	0.7	1.2	-0.3
Townsend deprivation index at recruitment	1.1	1.5	4.8	1.1	2.2	1.1	1.1	1.1	0.8	1.6	1.4	0.9	0.9	-0.2	2.1	0.4	1.1	0.9	-0.5	2.0	-0.1
Current tobacco smoking	0.1	0.1	0.6	0.4	-0.7	-0.3	0.2	-0.2	-0.4	-0.2	0.3	0.1	-0.2	-0.8	-0.0	-0.4	0.4	-0.1	-0.6	0.2	0.1
Average weekly fortified wine intake	1.1	1.3	3.6	-1.5	-1.0	-1.0	-1.5	-0.2	-0.2	-0.2	-1.6	-1.5	-1.1	1.0	-0.9	0.0	-1.9	-1.5	0.0	-1.6	-1.2
Maternal smoking around birth	0.3	0.5	1.1	-0.1	0.8	-0.9	-0.8	-1.1	-0.6	-1.0	-1.1	-0.8	-0.6	-0.0	-0.1	-0.5	-0.7	0.2	-0.0	-0.9	0.6
Fed-up feelings	0.6	1.0	2.0	-0.7	-1.2	-0.9	-1.3	-1.4	-1.1	-0.6	-0.9	-1.3	-1.3	-0.3	-1.2	-0.9	-1.1	-1.0	-1.0	-1.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	4.7	0.9	-0.6	-0.8	-0.7	-2.0	-2.0	-1.8	-0.6	-0.7	-1.3	-2.2	-0.9	-1.8	0.2	0.5	-2.0	-0.5	1.7
Relative age voice broke	0.5	0.8	3.4	-0.6	1.2	0.3	-0.3	0.8	1.1	0.6	0.2	0.0	0.6	1.8	1.0	1.2	-0.9	-0.4	1.5	-0.3	-1.0
Taking other prescription medications	0.3	0.4	1.2	0.4	-0.3	-0.5	-0.5	-0.8	-0.9	-0.7	-0.1	-0.6	-0.7	-1.1	-0.3	-1.0	-0.1	-0.1	-1.1	-0.4	0.6
Age when periods started (menarche)	0.8	2.0	4.2	-2.0	-1.4	-1.1	-1.4	0.1	-0.4	0.5	-1.4	-1.7	-1.8	-0.6	-1.7	-0.7	-1.6	-2.0	-1.6	-1.3	-1.8
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	3.5	1.2	-0.2	0.5	0.6	-1.9	-0.7	-1.8	-0.0	-0.0	-0.5	-1.3	-0.3	-0.6	0.5	0.9	-0.5	-0.1	1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	8.7	2.9	2.9	1.4	1.7	0.9	0.7	0.1	2.2	2.5	2.3	0.8	1.3	1.5	2.4	2.6	1.7	2.3	1.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.8	-0.7	0.1	0.5	0.5	0.9	0.7	1.4	0.6	0.2	0.4	0.5	0.4	0.5	0.1	0.0	-0.1	0.8	-0.7
Qualifications: CSEs or equivalent	0.3	0.4	1.7	0.4	-0.0	-1.1	-0.4	0.9	-0.7	0.7	0.4	0.1	-0.2	-0.8	0.6	-0.6	0.3	-0.0	-1.3	0.5	0.1
Serious illness, injury or assault to yourself	0.6	0.8	1.5	-1.0	-1.2	-0.9	-1.2	0.7	-0.0	0.7	-1.0	-1.0	-0.7	-0.1	-0.8	-0.8	-1.0	-1.2	-0.9	-0.6	-0.9
High blood pressure	0.1	0.4	1.3	0.7	-1.2	0.1	0.4	-0.8	-0.6	-0.5	0.6	-0.1	-0.5	-1.1	0.5	-0.6	0.5	0.1	-1.0	0.2	0.5
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.0	0.3	0.5	0.6	0.3	0.5	0.6	0.1	0.7	1.2	1.4	0.9	1.1	0.8	0.8	1.0	1.3	1.1	0.8
Multivitamins +/- minerals	0.6	0.8	2.5	0.6	0.7	-0.1	0.4	-1.4	-1.1	-0.8	0.1	-0.0	-0.6	-1.6	0.5	-0.7	0.6	1.2	-1.4	0.2	1.2
Stomach or abdominal pain in last month	0.5	0.7	1.8	-1.2	0.3	-1.2	-1.1	0.9	0.1	0.8	-0.8	-0.7	-0.1	0.8	-1.3	-0.4	-1.1	-0.5	-0.2	-0.2	-0.9
Supplements: Glucosamine	0.3	0.4	1.0	-0.2	0.9	1.0	0.6	0.6	0.7	0.9	0.4	0.3	0.6	0.9	0.4	0.9	-0.0	0.1	0.9	0.3	-0.6
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	5.1	-1.8	-1.7	-0.2	-1.1	0.2	0.2	0.5	-1.5	-1.5	-1.1	0.3	-1.4	-0.6	-1.9	-2.3	-0.2	-1.4	-2.0
Medication: Atenolol	0.3	0.4	0.8	-0.8	-0.8	-0.4	-0.5	0.2	-0.3	0.4	-0.9	-0.8	-0.7	-0.4	0.1	-0.4	-0.6	-0.7	-0.9	-0.4	-0.7
Medication: Levothyroxine sodium	0.5	0.8	2.9	1.0	-1.3	1.0	1.2	-0.2	0.1	0.1	1.7	1.2	0.5	-0.4	0.7	0.1	1.4	0.3	-0.2	1.0	0.7
Sitting height	0.0	0.2	0.7	-0.5	-0.3	-0.9	-0.4	-0.3	-0.4	-0.2	-0.6	-0.3	-0.4	-0.3	0.1	-0.2	-0.3	-0.8	-0.2	-0.4	-0.3
Chronic bronchitis/emphysema (father)	0.1	0.2	0.7	-0.2	-0.4	-0.1	-0.0	-0.4	-0.3	-0.1	0.1	-0.2	-0.4	-0.8	0.8	-0.2	-0.0	-0.1	-0.8	-0.1	-0.0
High blood pressure (mother)	1.3	1.8	4.1	0.3	-1.8	-1.4	-0.9	-1.7	-1.8	-2.0	-0.9	-0.7	-1.4	-1.6	-1.3	-1.8	-0.2	-0.3	-1.4	-1.2	1.1
Body mass index (BMI)	0.2	0.7	2.4	-1.1	-0.6	-0.3	-0.8	1.0	0.1	1.2	-0.7	-0.7	-0.5	-0.1	-0.5	-0.3	-0.9	-1.6	-0.8	-0.4	-1.3
Impedance of leg (left)	0.3	1.4	4.7	0.9	-0.7	-1.2	-1.2	-1.7	-1.4	-2.2	-1.6	-1.0	-1.1	-0.3	-1.6	-0.2	-0.6	0.1	-0.2	-1.2	1.1
Leg predicted mass (left)	0.1	0.5	2.6	0.2	0.4	-0.6	0.1	0.2	-0.7	0.4	0.4	0.2	-0.1	-1.6	0.5	-1.2	0.7	0.3	-1.6	0.8	0.4
Trunk fat mass	0.5	2.2	4.0	-1.4	-1.4	-1.6	-1.7	-0.4	-1.2	0.1	-1.8	-1.8	-1.8	-1.1	-1.7	-1.3	-1.6	-2.0	-1.9	-1.4	-1.1
Waist circumference	0.2	0.7	2.0	-0.7	-0.5	-0.8	-1.1	0.4	-0.6	0.7	-0.8	-0.9	-0.8	-1.0	-0.5	-0.9	-0.7	-1.1	-1.4	-0.4	-0.6
Number of incorrect matches in round	0.6	1.0	2.9	0.5	0.9	1.6	1.7	-0.2	1.0	0.7	1.3	1.0	0.9	0.2	1.7	0.9	0.9	0.8	0.7	0.9	0.1
Past tobacco smoking	0.2	0.4	1.7	-0.3	1.2	0.6	0.3	0.3	0.7	-0.3	0.5	0.7	0.9	0.6	0.4	0.6	0.4	0.9	1.3	0.2	0.6
Alcohol usually taken with meals	0.8	1.3	5.5	-1.5	-2.4	-0.6	-1.0	0.4	0.1	0.5	-0.4	-1.4	-0.9	0.5	-1.2	-0.4	-1.4	-1.9	-0.4	-1.1	-1.5
Nervous feelings	0.5	0.9	3.2	-1.5	-0.6	0.1	0.0	0.7	1.0	1.1	-0.6	-0.5	-0.3	1.4	-0.7	0.8	-1.2	-1.4	0.6	-0.8	-1.8
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	7.6	-1.4	-2.4	-1.5	-2.3	-1.1	-1.1	-0.7	-2.8	-2.1	-2.0	0.1	-1.6	-0.9	-2.3	-2.1	-1.1	-2.4	-0.9
Hearing difficulty/problems with background noise	0.3	0.5	2.1	0.1	1.1	0.4	-0.4	-0.1	0.8	0.0	-1.0	0.0	0.6	1.3	-0.1	0.9	-0.4	0.4	1.4	-0.1	0.2
Hair/balding pattern: Pattern 2	0.4	0.6	1.1	-0.9	0.1	-0.7	-0.8	-0.1	-0.6	0.5	-0.4	-1.0	-1.0	-0.3	-0.5	-0.5	-1.0	-1.0	-1.0	-0.9	-1.0
Had menopause	0.3	0.4	1.3	0.5	0.9	-0.4	-0.6	-0.5	-0.4	-1.0	-0.7	-0.2	0.1	0.9	-0.1	0.5	-0.5	0.5	1.1	-0.8	0.4
Had other major operations	2.9	3.6	12.0	3.5	1.2	1.0	1.8	-1.9	-1.1	-2.3	1.4	1.9	1.1	-0.7	0.6	0.5	2.6	3.0	0.7	1.3	3.2
Forced vital capacity (FVC)	0.4	1.6	6.2	1.0	0.2	-1.2	-0.6	-1.8	-2.0	-2.5	-0.2	-0.1	-0.8	-1.6	-0.8	-1.6	0.6	1.1	-0.7	-0.5	2.1
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.1	6.6	2.3	2.6	1.2	1.4	1.4	1.0	0.7	2.0	2.1	2.2	1.2	1.8	1.5	1.8	1.9	1.7	2.2	1.1
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	5.2	-0.3	0.6	-1.7	-2.0	-1.3	-1.1	-1.6	-2.3	-1.5	-1.1	-0.0	-1.9	-1.1	-1.6	-0.2	-0.0	-1.7	0.5
Qualifications: None of the above	0.5	1.1	3.0	-0.1	-1.7	-0.5	-0.4	-1.4	-0.9	-0.6	-0.2	-1.0	-1.5	-1.4	-1.1	-1.7	-0.4	-0.9	-1.6	-1.0	-0.1
Financial difficulties in last 2 years	0.7	1.0	3.7	-0.3	-1.9	-0.7	-0.7	-0.5	-0.7	-0.2	-1.3	-1.2	-1.3	-1.2	-0.7	-0.6	-0.8	-1.3	-1.6	-0.7	-0.5
Mouth/teeth dental problems	2.2	3.4	7.6	-0.6	0.8	2.2	1.2	2.8	2.5	2.8	1.4	1.9	2.4	2.1	0.9	2.3	0.7	-0.2	2.1	1.9	-1.4
Heart attack	0.2	0.3	0.9	0.4	-0.3	-0.2	0.3	0.7	0.6	1.0	0.7	0.3	0.4	0.6	1.0	0.8	0.2	-0.1	0.1	0.6	-0.4
Allergy	0.3	0.7	2.1	-0.7	-0.5	-1.0	-0.8	0.5	-0.2	0.6	-0.7	-1.0	-1.0	0.3	-0.8	-0.3	-1.1	-1.5	-0.6	-1.1	-1.2
Pain all over the body in last month	0.9	1.0	2.4	0.2	0.6	1.0	1.0	1.1	1.2	1.3	0.9	1.3	1.1	0.8	1.5	1.2	0.8	0.2	0.7	1.3	-0.4
Diabetes (self-reported)	0.3	0.5	3.0	-0.3	1.7	-0.2	-1.2	-0.7	-0.2	-0.4	-1.1	-0.8	-0.4	0.2	-0.6	-0.7	-1.0	0.1	0.2	-0.6	0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	0.4	-0.4	-0.1	-0.1	-0.9	-0.8	-0.9	-0.2	-0.3	-0.4	-0.2	0.1	-0.7	0.1	0.6	-0.2	-0.2	0.9
Medication: Ramipril	0.4	0.5	1.6	-1.0	-0.4	-0.2	-0.7	0.1	0.2	0.4	-0.4	-1.1	-0.8	0.3	-0.4	-0.1	-1.3	-1.2	-0.3	-0.8	-1.1
Medication: Simvastatin	0.6	0.9	2.0	0.7	1.3	1.4	1.3	-1.1	0.5	-0.3	1.1	0.9	0.8	0.1	1.1	0.7	0.8	1.3	1.0	0.7	0.8
Fluid intelligence score	1.2	2.6	8.1	0.7	-0.1	-2.2	-1.3	-2.0	-2.4	-2.8	-1.4	-1.0	-1.4	-2.1	-1.0	-1.8	-0.1	0.7	-1.5	-1.1	1.9
Illnesses of siblings	1.1	1.5	3.6	-0.4	-0.1	-1.1	-1.4	-1.1	-1.4	-1.2	-1.3	-1.4	-1.4	-1.8	-1.8	-1.9	-0.7	-0.4	-1.5	-1.0	0.4
Neuroticism score	1.4	2.9	5.9	-1.5	-1.5	-1.7	-2.2	-1.4	-1.2	-0.6	-2.3	-2.3	-2.1	0.0	-1.7	-0.9	-2.4	-1.9	-1.2	-2.3	-1.1
Weight	0.2	0.7	3.0	-0.5	-0.1	-1.2	-1.0	0.2	-1.0	0.3	-0.8	-0.8	-0.9	-1.3	-0.7	-1.1	-0.4	-0.8	-1.7	-0.3	-0.3
Impedance of arm (right)	0.3	1.4	4.0	-0.1	-1.5	-0.8	-0.7	-2.0	-1.0	-1.8	-1.3	-1.1	-1.4	-0.9	-1.9	-0.5	-0.8	-0.5	-0.6	-1.5	0.4
Arm fat percentage (right)	0.6	2.3	6.4	-1.9	-1.6	-1.0	-1.7	0.3	-0.4	0.6	-1.7	-1.8	-1.6	-0.3	-1.8	-0.8	-1.9	-2.5	-1.3	-1.6	-1.8
Trunk fat-free mass	0.3	1.6	4.4	1.4	2.1	-0.2	0.8	0.3	-0.7	0.0	1.1	1.1	0.7	-1.6	1.2	-0.9	1.8	2.0	-0.9	1.8	1.6
Hip circumference	0.2	0.8	2.5	-1.2	-1.0	-0.6	-1.0	0.7	-0.2	0.9	-0.9	-0.8	-0.6	-0.4	-1.1	-0.1	-0.9	-1.6	-0.9	-0.5	-1.1
Time employed in main current job	1.2	1.4	3.4	-0.8	1.2	1.6	1.3	1.2	1.8	1.9	1.0	0.9	1.2	1.2	1.2	1.3	0.2	0.4	1.3	1.0	-1.0
Alcohol intake versus 10 years previously	0.2	0.2	1.2	-0.2	-0.4	0.5	0.1	0.5	0.1	1.1	0.4	-0.2	-0.3	-0.6	-0.0	-0.3	-0.0	-0.5	-1.0	0.2	-0.8
Father’s age at death	0.2	0.2	0.9	-0.7	-0.7	-0.2	-0.1	1.0	0.2	0.4	-0.5	-0.1	0.0	0.1	-0.8	0.5	-0.1	-0.4	0.0	0.1	-0.6
Worrier / anxious feelings	0.4	0.7	2.1	-1.3	-0.3	-0.4	-0.6	0.4	0.2	0.9	-0.7	-0.9	-0.6	1.2	-0.0	0.1	-1.3	-1.2	-0.1	-0.8	-1.4
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	6.5	-1.3	-2.1	-1.6	-1.7	-1.8	-1.7	-0.8	-2.0	-2.4	-2.5	-1.6	-1.1	-2.0	-1.9	-1.7	-2.5	-2.0	-0.8
Falls in the last year	3.1	4.2	14.3	-3.7	-1.8	0.1	-1.3	1.9	1.4	2.9	-1.4	-1.7	-1.0	1.4	-0.6	0.5	-2.6	-3.4	-0.5	-1.2	-3.8
Hair/balding pattern: Pattern 3	0.4	0.6	2.7	1.2	0.7	-0.6	-0.3	-1.1	-0.9	-1.7	-0.6	-0.2	-0.3	-0.4	-0.5	-0.7	0.1	1.0	0.0	-0.5	1.2
Number of live births	1.9	2.7	8.2	-1.9	-1.8	-0.7	-1.5	0.5	0.4	0.7	-1.8	-1.8	-1.2	1.0	-2.3	0.3	-2.4	-2.9	0.2	-2.0	-2.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.5	0.3	0.3	-0.9	-0.7	-1.0	-1.4	-1.6	-0.3	-0.3	-0.7	-1.1	-0.6	-1.3	0.1	0.5	-0.7	-0.6	1.2
Pulse rate	0.8	1.3	2.9	-0.3	0.4	1.4	0.5	1.7	1.7	1.4	0.1	0.6	1.2	1.6	1.5	1.3	-0.0	-0.5	1.6	0.7	-1.2
Happiness	0.4	0.5	1.9	-0.5	-0.5	-0.7	-0.9	-0.8	-0.8	-0.4	-1.4	-1.0	-0.9	-0.1	-0.1	-0.2	-1.1	-0.3	-0.3	-1.0	-0.2
Noisy workplace	0.8	1.0	2.7	-0.6	-0.8	-1.1	-1.6	0.3	-0.1	0.4	-1.1	-1.2	-1.0	0.6	-0.6	-0.2	-1.5	-1.4	-0.3	-1.4	-1.2
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.5	-0.4	0.7	0.8	0.6	1.4	1.3	1.4	0.4	0.6	1.0	1.1	1.0	1.6	0.1	0.1	0.9	0.8	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.1	0.3	1.0	-0.2	0.1	-0.0	-0.5	-0.2	0.3	0.5	0.3	-0.1	0.4	-0.3	0.7	1.0	-0.2	0.6	0.8
Mouth/teeth dental problems: Dentures	0.5	0.9	1.9	-0.2	-0.2	-1.4	-0.9	-1.1	-1.4	-1.1	-0.8	-0.9	-1.3	-0.9	-1.0	-1.0	-0.5	-0.4	-1.2	-1.0	0.2
Asthma	1.9	3.7	8.6	2.1	1.9	2.8	2.9	-1.2	0.9	-0.4	2.0	2.1	2.0	-0.5	1.4	0.8	2.5	2.9	1.4	2.3	1.8
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	4.1	-2.0	-0.6	-0.2	-0.4	1.3	0.3	1.8	0.2	-1.1	-0.9	-0.1	-1.0	-0.5	-1.0	-1.4	-1.4	-0.1	-2.0
Medication: Cholesterol lowering	0.5	0.8	3.7	0.7	-0.6	-0.1	0.2	-1.9	-1.0	-1.2	0.2	-0.4	-0.9	-1.5	-0.1	-1.2	0.2	0.3	-1.1	-0.4	0.9
Depression (self-reported)	0.4	0.5	1.7	1.3	0.1	0.4	0.6	-0.9	-0.5	-0.7	0.6	0.5	0.1	-1.2	-0.5	-0.4	0.9	0.9	-0.4	0.4	1.2
Medication: Lansoprazole	0.1	0.1	0.7	0.0	-0.6	0.3	-0.1	0.0	-0.0	-0.2	-0.4	-0.2	-0.1	0.3	-0.8	0.2	-0.3	-0.1	0.3	-0.2	-0.3
Prospective memory result	1.9	2.4	5.1	-1.0	-0.5	-1.9	-2.3	-0.5	-1.2	-0.6	-2.3	-2.0	-2.0	-0.8	-1.7	-1.1	-2.0	-1.5	-1.5	-1.9	-0.6
Lung cancer (father)	1.3	1.6	5.4	-2.3	-0.3	-0.7	-1.3	1.1	0.2	1.5	-1.3	-1.4	-0.9	0.2	-0.8	-0.4	-1.6	-2.0	-0.9	-0.9	-1.9
Illnesses of mother	0.9	1.1	3.0	-0.5	0.2	1.5	0.8	1.1	1.7	1.3	0.4	0.4	1.0	1.4	0.4	1.7	-0.1	-0.2	1.4	0.7	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.1	-0.2	-0.2	-1.9	-1.5	-1.2	-2.0	-1.8	-0.9	-1.0	-1.4	-1.5	-0.5	-1.8	-0.4	-0.1	-1.5	-1.1	1.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.6	0.5	0.6	-0.2	-0.1	-0.0	-0.3	-0.3	-0.3	0.4	0.3	-0.3	0.3	-0.2	0.5	0.6	0.1	0.3	0.8
Impedance of arm (left)	0.3	1.3	4.6	-0.3	-2.1	-0.6	-0.7	-1.6	-0.8	-1.4	-1.2	-1.1	-1.3	-0.5	-1.8	-0.3	-0.9	-1.0	-0.4	-1.5	-0.0
Arm fat mass (right)	0.4	1.5	4.1	-1.5	-1.0	-1.1	-1.4	0.5	-0.5	0.8	-1.3	-1.4	-1.3	-0.7	-1.2	-1.0	-1.3	-2.0	-1.6	-1.0	-1.4
Trunk predicted mass	0.3	1.7	4.7	1.4	2.2	-0.2	0.9	0.2	-0.7	-0.1	1.1	1.1	0.8	-1.6	1.3	-0.9	1.9	2.0	-1.0	1.8	1.6
Standing height	0.2	2.4	7.5	1.5	0.9	-1.8	-0.4	-1.7	-2.4	-1.9	-0.4	-0.2	-0.8	-2.7	-0.6	-1.9	1.0	1.6	-2.0	0.4	2.3
Length of working week for main job	0.3	0.3	1.5	0.7	-0.5	-0.2	-0.0	-0.8	-0.4	-1.2	-0.2	0.1	-0.0	-0.3	-0.2	-0.3	0.4	0.6	0.3	-0.2	1.1
Exposure to tobacco smoke at home	1.3	1.5	3.2	0.1	-0.7	-1.8	-1.5	-0.9	-1.6	-1.2	-1.3	-1.3	-1.5	-1.0	-1.7	-1.1	-0.9	-0.8	-1.4	-1.5	0.2
Breastfed as a baby	0.3	0.4	1.7	1.3	-0.2	0.5	0.7	-1.2	-0.5	-1.0	0.3	0.3	0.0	-0.1	-0.3	0.5	0.7	0.6	0.1	0.2	0.8
Tense / ‘highly strung’	1.6	2.6	7.2	-2.0	-2.7	-1.2	-1.6	0.6	0.4	0.8	-2.1	-1.5	-1.1	1.5	-1.2	0.2	-2.2	-2.5	0.2	-2.0	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.8	-1.2	-0.7	-1.0	-1.0	-0.8	-0.6	-0.1	-1.1	-1.4	-1.2	-0.6	-2.0	-0.9	-1.2	-1.1	-1.1	-1.2	-0.6
Hair/balding pattern: Pattern 4	0.5	1.2	2.7	0.4	0.6	1.2	1.3	1.1	1.0	1.1	1.4	1.4	1.4	0.6	1.2	1.2	1.3	0.8	0.8	1.6	0.4
Birth weight of first child	1.6	2.9	8.8	2.3	1.1	-1.1	-0.2	-2.5	-2.1	-3.0	-0.6	-0.2	-0.9	-2.3	-0.6	-2.2	1.0	1.9	-1.3	-0.3	2.7
Peak expiratory flow (PEF)	0.1	0.2	1.5	-0.5	-0.0	-0.3	-0.6	0.0	-0.1	-0.4	-0.8	-0.4	-0.3	0.2	-1.2	-0.3	-0.6	-0.3	0.2	-0.6	-0.1
Pulse wave reflection index	1.0	1.2	2.9	1.4	1.1	0.2	0.9	0.1	0.1	-0.1	1.4	1.3	1.3	0.2	0.8	0.4	1.7	1.7	0.7	1.5	1.6
Ever highly irritable/argumentative for 2 days	1.1	1.4	3.7	1.3	0.6	1.1	1.4	0.0	0.2	-0.2	1.3	1.4	1.2	-0.4	1.5	0.1	1.9	1.7	0.2	1.8	1.4
Loud music exposure frequency	0.9	1.0	3.3	-1.8	-0.9	0.1	-0.5	1.0	0.9	1.2	-0.9	-0.7	-0.4	0.4	-0.2	0.5	-1.1	-1.7	-0.0	-0.7	-1.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.7	-0.3	-0.4	-0.5	-0.6	-0.9	-0.8	-0.8	-1.3	-1.1	-1.1	-0.8	-0.5	-0.8	-0.6	-0.2	-0.9	-0.9	0.3
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.5	0.4	-0.2	-1.9	-1.2	-1.4	-1.7	-1.6	-1.1	-1.4	-1.5	-1.4	-0.6	-1.6	-0.5	0.4	-1.6	-1.1	1.2
Blood clot in the leg (DVT)	0.4	0.5	1.2	0.6	-0.9	-1.1	-0.9	-0.2	-0.9	-0.7	-0.8	-0.5	-0.6	-1.0	-0.7	-0.4	-0.0	-0.1	-0.9	-0.2	0.8
Medication: Paracetamol	2.0	3.3	8.4	-2.2	-1.4	-1.6	-1.7	0.1	-0.9	1.1	-1.2	-2.3	-2.3	-0.8	-1.4	-1.5	-2.3	-2.9	-2.6	-1.6	-2.5
Headache pain in last month	0.1	0.2	1.5	-0.2	-1.2	-0.1	-0.4	0.4	0.1	0.6	0.1	-0.4	-0.3	0.2	0.4	0.1	-0.5	-0.9	-0.3	-0.0	-0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.7	-0.6	1.1	-0.6	-1.0	1.6	0.6	0.7	-1.2	0.0	0.6	1.5	-0.2	1.0	-0.6	-0.3	1.2	-0.3	-0.5
Glaucoma (self-reported)	2.1	2.5	4.2	0.2	-1.1	-1.8	-1.4	-2.0	-1.7	-2.0	-2.0	-1.8	-2.0	-1.4	-1.5	-1.8	-1.1	-0.6	-1.2	-2.0	0.8
Gout (self-reported)	0.3	0.4	1.6	-0.8	0.7	0.7	0.4	0.8	0.8	1.3	0.2	0.4	0.5	0.6	0.4	0.7	-0.2	-0.5	0.3	0.7	-1.1
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.3	0.4	-0.6	1.9	1.6	1.3	1.7	1.5	2.1	1.7	1.5	1.1	0.5	1.4	1.1	-0.1	1.2	1.4	-0.7
Medication: Amlodipine	0.3	0.5	2.4	0.4	1.2	0.2	0.5	0.4	0.3	0.8	1.1	0.5	0.4	-0.3	1.6	0.3	0.5	0.6	-0.4	1.0	0.1
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.2	1.0	0.9	-0.4	-0.3	-1.1	-1.2	-1.5	-0.5	-0.2	-0.3	-0.9	-0.2	-0.7	0.3	1.1	-0.3	-0.0	1.3
Birth weight	0.4	0.9	4.1	-0.8	-1.1	-1.0	-1.3	0.4	-0.5	0.1	-1.0	-0.9	-0.8	0.1	-2.0	-0.6	-1.1	-1.2	-0.6	-0.8	-0.8
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.5	0.4	0.4	0.5	0.5	-0.4	-0.3	0.2	0.4	-0.1	-0.3	-1.2	0.7	-0.8	0.5	0.7	-1.2	0.4	0.4
High blood pressure (siblings)	0.2	0.3	1.3	-0.1	-1.1	-0.1	0.2	0.3	0.3	0.1	0.2	0.2	0.4	1.2	0.2	0.8	-0.1	-0.1	0.9	-0.2	-0.2
Forced vital capacity (FVC), Best measure	0.5	1.8	5.4	0.4	0.2	-1.8	-1.2	-1.7	-2.2	-2.3	-0.7	-0.8	-1.2	-1.7	-0.6	-1.8	0.0	0.5	-1.2	-1.0	1.8
Body fat percentage	0.6	2.6	5.5	-1.5	-1.7	-1.4	-1.8	-0.5	-1.1	-0.0	-2.1	-2.0	-1.9	-0.7	-2.1	-1.0	-1.9	-2.4	-1.6	-1.8	-1.3
Leg fat percentage (right)	0.2	0.8	3.0	-1.1	-1.1	-0.3	-0.9	0.4	-0.0	0.7	-1.3	-0.8	-0.6	0.4	-1.2	0.3	-1.1	-1.7	-0.1	-0.8	-1.3
Arm fat-free mass (right)	0.1	0.6	1.6	0.5	1.3	-0.7	0.0	0.5	-0.8	0.4	0.4	0.3	0.1	-1.2	0.8	-1.0	0.9	0.8	-1.3	1.0	0.7
Exposure to tobacco smoke outside home	0.8	1.1	4.2	1.2	-0.6	0.6	0.8	-2.0	-1.2	-1.3	0.3	0.1	-0.5	-1.7	0.5	-1.2	1.1	0.9	-1.1	-0.0	1.4
Comparative body size at age 10	0.2	0.5	1.2	1.0	0.2	-1.0	0.3	0.2	-0.9	-0.4	0.4	0.9	0.6	-0.3	0.9	-0.2	1.0	0.8	0.1	0.7	1.1
Number of full brothers	0.6	0.8	2.9	-0.1	0.0	-0.1	-0.2	1.3	1.1	1.0	0.2	0.3	0.7	1.7	-0.4	1.6	-0.6	-0.7	1.3	-0.1	-1.0
Worry too long after embarrassment	1.7	2.9	6.5	-1.9	-1.7	-1.4	-2.1	-0.4	-0.6	0.1	-2.2	-2.4	-2.0	0.2	-1.5	-0.9	-2.6	-2.2	-1.3	-2.1	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.1	1.2	-0.7	-0.5	0.0	-1.5	-0.9	-1.8	-0.0	0.1	-0.3	-0.9	-1.7	-0.9	0.6	0.9	-0.0	-0.3	1.6
Wheeze or whistling in the chest in last year	0.2	0.3	1.6	-0.3	1.3	0.3	-0.4	0.1	0.3	0.5	-0.7	-0.6	-0.2	0.6	0.1	0.1	-0.8	-0.3	0.2	-0.5	-0.7
Number of children fathered	0.3	0.4	0.9	-0.3	-0.6	0.0	0.4	0.8	0.8	0.6	0.3	0.7	0.8	0.9	0.5	0.7	0.4	0.1	0.9	0.4	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.1	-0.5	-0.7	-1.8	-1.5	0.1	-0.9	-0.2	-1.4	-1.1	-1.2	-0.6	-1.0	-1.0	-0.9	-0.9	-1.3	-1.1	-0.2
Age at first live birth	0.2	0.4	2.7	0.4	0.6	0.4	0.4	-0.8	0.4	-0.5	0.2	0.6	0.7	1.0	0.7	0.8	0.2	0.4	1.6	0.0	0.5
Pulse wave peak to peak time	0.1	0.2	0.6	-0.5	-0.8	-0.1	-0.1	-0.2	-0.0	0.1	0.1	-0.5	-0.5	0.0	-0.5	-0.1	-0.5	-0.6	-0.4	-0.4	-0.6
Health satisfaction	0.6	0.8	1.5	0.4	-0.7	-0.7	-1.1	-1.1	-1.2	-0.9	-1.2	-1.2	-1.2	-0.3	-0.3	-0.7	-0.9	-0.4	-0.9	-1.2	0.3
Shortness of breath walking on level ground	0.8	0.9	2.4	-1.2	0.4	-0.7	-1.0	-0.6	-0.3	0.4	-1.0	-1.5	-1.2	-0.3	0.1	-0.8	-1.6	-1.1	-1.3	-0.9	-1.1
Qualifications: College or University degree	0.6	2.0	6.4	1.0	2.5	1.2	1.2	1.1	1.3	0.7	1.4	1.7	2.0	1.0	1.2	1.4	1.3	1.6	1.7	1.6	0.5
Eye problems/disorders: None of the above	0.3	0.3	0.8	0.6	-0.3	0.2	0.6	0.8	0.6	0.4	0.5	0.9	0.7	0.3	0.4	0.8	0.6	-0.1	0.6	0.7	-0.0
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.2	-0.4	-0.7	-1.7	-1.8	0.3	-0.9	-0.1	-1.0	-1.5	-1.1	0.1	-0.7	-0.8	-1.3	-0.8	-0.8	-1.0	-0.5
Emphysema/chronic bronchitis	0.8	0.9	2.8	0.2	0.3	0.4	0.4	1.7	1.1	1.4	1.2	0.6	0.9	1.5	0.6	1.5	0.2	0.1	0.8	0.9	-0.7
Medication for pain relief, constipation, heartburn	0.8	1.4	5.3	1.6	1.2	-0.5	-0.3	-1.1	-0.5	-2.3	-0.8	0.6	0.7	0.5	-0.7	0.4	0.5	1.6	1.9	-0.4	2.1
Neck or shoulder pain in last month	1.6	2.3	7.8	-1.7	-2.8	-0.8	-1.4	-0.7	-0.6	-0.5	-2.0	-1.7	-1.7	0.5	-1.0	-0.3	-2.0	-2.4	-0.4	-2.1	-1.3
Medication: Blood pressure	0.2	0.4	1.1	0.6	-0.5	0.7	0.9	-0.8	-0.2	0.0	1.1	-0.0	-0.3	-1.0	0.9	-0.6	0.4	0.1	-0.9	0.4	-0.0
Angina (self-reported)	0.8	1.1	3.3	0.3	1.6	1.0	0.3	1.2	1.3	1.6	0.6	0.2	0.8	1.2	1.8	1.3	-0.3	-0.2	0.9	0.5	-1.2
Migraine (self-reported)	0.4	0.5	2.5	0.2	-0.1	0.6	0.8	0.2	0.3	0.5	1.6	0.9	0.7	0.1	1.5	0.6	0.8	0.3	0.3	1.0	0.1
Medication: Ibuprofen	1.0	1.2	4.3	-2.1	-0.7	-0.0	-0.4	1.7	0.5	2.0	0.2	-0.8	-0.5	0.2	-0.7	-0.3	-0.9	-1.3	-1.1	0.1	-2.1
Medication: Allopurinol	0.3	0.4	1.6	-0.7	-0.2	0.5	0.5	1.0	0.7	1.2	0.5	0.4	0.5	0.3	0.5	0.4	0.1	-0.4	-0.1	0.9	-0.8
Medication: Omeprazole	0.2	0.2	0.5	0.4	0.6	0.5	0.3	0.4	0.4	0.3	0.3	0.6	0.7	0.2	0.4	0.7	0.5	0.4	0.4	0.7	0.2
Medication: Seretide 50 evohaler	0.4	0.5	2.4	0.6	1.6	0.6	0.7	-0.4	0.1	0.2	0.6	0.7	0.6	-0.5	0.6	0.4	0.8	0.9	-0.2	0.8	0.6
Mean time to correctly identify matches	0.2	0.3	1.1	0.1	0.6	0.7	0.5	-0.7	0.2	-0.3	0.4	0.7	0.7	0.8	-0.3	0.4	0.3	0.7	1.0	0.1	0.5
Heart disease (mother)	0.3	0.4	1.3	0.4	-0.1	-0.9	-0.6	-0.2	-1.0	-0.4	0.2	-0.2	-0.6	-0.9	0.1	-1.1	-0.0	0.1	-1.0	-0.2	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.8	0.5	0.1	1.2	2.0	-0.2	0.6	0.2	1.3	1.6	1.3	-0.2	0.9	0.8	1.8	1.5	0.6	1.6	1.0
Whole body fat mass	0.5	2.0	3.6	-1.3	-1.0	-1.5	-1.7	-0.3	-1.1	0.1	-1.9	-1.7	-1.7	-1.0	-1.7	-1.2	-1.5	-1.9	-1.8	-1.4	-1.0
Leg fat mass (right)	0.2	0.8	2.3	-1.0	-0.6	-0.8	-1.0	0.5	-0.4	0.8	-1.2	-0.9	-0.8	-0.3	-1.0	-0.4	-1.0	-1.5	-1.0	-0.6	-1.1
Arm predicted mass (right)	0.2	0.8	2.0	0.9	1.4	-0.4	0.3	0.6	-0.7	0.4	0.8	0.7	0.4	-1.2	1.0	-0.8	1.2	1.1	-1.1	1.4	0.9
Pulse rate, automated reading	0.7	2.1	5.3	-0.3	0.2	1.5	1.0	2.3	1.9	1.8	0.6	1.2	1.5	2.0	1.6	2.2	0.3	-0.5	2.1	0.8	-1.4
Alcohol intake frequency.	0.3	0.6	2.1	-1.5	-0.2	0.2	-0.3	0.8	0.4	1.4	0.4	-0.7	-0.5	-0.9	0.0	-0.5	-0.5	-0.7	-1.3	0.2	-1.2
Comparative height size at age 10	0.4	2.0	5.7	0.8	0.8	-1.4	-0.3	-2.0	-2.1	-1.5	-0.5	-0.9	-1.3	-2.4	-0.4	-2.0	0.4	1.2	-1.9	-0.3	1.8
Number of full sisters	0.4	0.5	1.8	-0.7	-0.4	-0.7	-1.0	0.4	0.1	0.7	-0.6	-0.6	-0.4	0.4	-1.1	0.3	-0.9	-1.3	-0.4	-0.5	-1.0
Suffer from ‘nerves’	1.6	2.5	7.8	-1.6	-2.8	-0.9	-1.2	-0.3	-0.1	0.1	-1.7	-1.6	-1.4	0.7	-2.0	-0.1	-2.1	-2.7	-0.1	-2.3	-1.8
Overall health rating	0.7	1.6	5.1	-1.7	-1.4	-0.4	-1.0	1.1	0.7	1.8	-1.0	-1.1	-0.6	1.1	-0.1	0.5	-1.8	-2.1	-0.2	-0.9	-2.2
Chest pain or discomfort	0.9	1.3	4.4	-0.0	1.0	0.7	0.8	1.5	1.3	1.8	1.2	1.0	1.2	1.0	2.1	1.2	0.4	0.0	0.6	1.3	-0.9
Had major operations	1.1	1.3	3.6	1.1	0.8	-1.3	-0.9	-1.8	-1.6	-1.9	-0.7	-0.7	-0.9	-0.7	-1.6	-0.9	-0.0	0.8	-0.7	-0.8	1.6
Age at last live birth	0.2	0.3	1.0	-0.1	-0.2	0.6	0.5	-0.6	0.5	0.3	0.4	0.3	0.2	0.9	0.5	0.8	-0.1	-0.5	1.0	-0.2	-0.4
Family relationship satisfaction	0.3	0.4	1.9	-0.5	0.8	-0.6	-1.0	-0.3	-0.3	-0.1	-1.4	-0.9	-0.6	0.2	-0.2	-0.0	-1.1	0.1	-0.2	-0.6	-0.2
Leg pain on walking	0.3	0.4	1.3	-0.2	0.4	-0.4	-0.8	-0.3	-0.1	0.1	-1.2	-1.0	-0.7	0.2	-0.3	0.1	-1.1	-0.8	-0.2	-1.1	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.5	0.7	0.6	0.4	1.0	0.2	-0.2	0.2	0.8	0.9	0.6	-0.7	0.3	-0.1	1.2	1.0	-0.4	1.1	0.8
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.0	-0.5	-1.7	-1.2	-1.2	-0.7	-0.6	-0.5	-1.7	-1.4	-1.1	-0.2	-1.6	-0.6	-1.5	-1.1	-0.4	-1.6	-0.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.7	-0.3	-0.0	0.8	0.3	-0.6	0.5	-0.1	0.4	-0.0	0.1	0.6	-0.1	0.3	-0.3	-0.1	0.9	-0.4	-0.2
Medication: Aspirin	0.7	0.9	4.4	1.1	0.8	0.5	0.9	-0.2	-0.2	0.2	1.0	0.5	0.2	-1.2	2.1	-0.7	1.2	1.2	-1.1	1.2	0.7
Supplements: Vitamin C	1.3	1.6	5.3	1.8	2.0	-0.8	0.3	-0.3	-0.8	-0.4	1.2	0.9	0.5	-1.5	0.2	-0.7	1.6	2.3	-1.0	1.3	1.9
Knee pain experienced in last month	0.1	0.2	0.7	0.7	-0.2	0.0	0.2	0.2	-0.2	0.3	0.6	0.4	-0.0	-0.3	0.8	-0.2	0.5	0.2	-0.7	0.2	0.4
Hypertension (Self-reported)	0.2	0.5	1.4	0.9	-1.2	0.4	0.6	-0.9	-0.5	-0.7	0.7	0.1	-0.3	-1.0	0.6	-0.5	0.7	0.3	-0.8	0.3	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	-0.6	-0.1	0.7	0.7	0.6	0.7	0.7	0.3	0.4	0.3	0.2	-0.2	0.2	0.1	-0.4	0.2	0.4	-0.8
Illnesses of father: Heart disease	0.2	0.3	1.1	0.9	1.0	0.4	0.3	0.6	0.5	0.7	0.5	0.1	0.1	0.3	0.8	0.6	-0.1	0.0	-0.1	0.3	-0.4
Illnesses of siblings: Diabetes	1.7	2.1	4.6	0.6	-0.7	1.5	1.4	1.6	2.0	1.9	1.5	1.6	1.6	1.5	1.4	2.1	0.8	-0.4	1.7	1.1	-0.8
Smoking status: Previous	0.1	0.1	0.7	0.5	-0.3	-0.3	-0.1	-0.1	-0.3	0.4	-0.0	-0.3	-0.4	-0.3	0.1	-0.1	-0.2	-0.4	-0.8	0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.2	0.3	0.5	0.4	1.1	0.8	0.2	0.9	1.6	1.1	0.7	-1.4	1.3	-0.2	1.5	1.1	-0.9	1.8	0.4
Whole body fat-free mass	0.2	1.1	3.1	1.0	1.5	-0.5	0.5	0.2	-0.9	0.1	0.8	0.7	0.3	-1.8	0.9	-1.1	1.4	1.4	-1.4	1.4	1.3
Leg fat-free mass (right)	0.1	0.6	2.9	0.4	0.7	-0.8	-0.1	0.2	-0.9	0.2	0.4	0.1	-0.2	-1.7	0.5	-1.2	0.7	0.5	-1.7	0.7	0.6
Arm fat percentage (left)	0.5	2.1	6.9	-1.9	-1.8	-0.9	-1.5	0.4	-0.3	0.9	-1.5	-1.6	-1.4	-0.2	-1.6	-0.6	-1.8	-2.6	-1.2	-1.4	-1.9
Average weekly red wine intake	0.5	0.7	2.1	1.5	-0.5	0.1	0.4	0.3	0.3	-0.5	0.5	1.1	1.1	0.9	-0.3	0.9	0.9	1.0	1.4	0.7	1.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.2	-0.3	-0.7	-0.3	-0.5	0.4	0.4	0.2	-0.1	-0.2	-0.0	0.9	-1.1	0.5	-0.7	-0.7	0.6	-0.5	-0.8
Mood swings	1.2	2.1	4.4	-0.8	-1.2	-1.3	-1.3	-2.1	-1.6	-0.9	-1.4	-1.9	-2.0	-1.1	-1.2	-1.7	-1.4	-1.1	-1.8	-1.7	-0.2
Loneliness, isolation	0.7	0.9	2.7	-1.6	0.0	-0.7	-0.9	-0.3	-0.1	0.4	-1.2	-1.4	-1.1	-0.0	-1.1	-0.2	-1.6	-0.9	-0.6	-1.2	-1.2
Long-standing illness, disability or infirmity	0.8	1.2	3.7	-1.6	-0.2	-0.2	-1.3	1.2	0.7	1.4	-0.9	-1.2	-0.4	0.6	-0.4	0.2	-1.7	-1.8	-0.1	-0.8	-1.9
Ever had bowel cancer screening	1.4	1.6	4.8	-1.9	-0.1	-0.6	-1.2	0.7	0.4	1.3	-1.0	-1.6	-0.7	1.6	-0.8	-0.3	-2.2	-1.7	0.2	-1.2	-2.2
Diabetes diagnosed by doctor	0.3	0.5	1.7	-0.7	1.3	-0.1	-1.2	-0.4	0.1	0.0	-1.1	-0.8	-0.3	0.3	-0.6	-0.6	-1.2	-0.3	0.3	-0.6	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.7	-0.7	-0.4	-0.4	0.0	0.9	0.4	1.3	0.1	-0.1	-0.1	0.0	0.0	-0.1	-0.3	-0.6	-0.7	0.4	-1.0
Friendships satisfaction	0.1	0.2	0.8	0.1	0.6	0.0	0.1	-0.5	-0.0	-0.3	-0.7	-0.1	0.2	0.5	-0.2	0.4	-0.2	0.9	0.8	0.0	0.4
Qualifications: nursing, teaching	0.0	0.1	0.3	-0.1	0.4	-0.5	-0.3	0.1	-0.3	0.1	-0.3	-0.3	-0.2	-0.2	0.2	-0.3	-0.3	0.1	-0.1	-0.2	-0.0
Commuting to job workplace: Walk	0.2	0.2	1.0	-0.1	-1.0	-0.2	-0.3	0.2	-0.4	0.1	0.3	-0.2	-0.4	-0.2	-0.6	-0.2	-0.0	-0.8	-0.7	-0.1	-0.3
Eye problems/disorders: Cataract	0.5	0.6	2.0	0.7	0.9	0.3	0.6	-0.0	-0.3	-0.1	1.4	0.4	0.3	-0.8	0.7	-0.5	1.0	1.4	-0.6	1.1	1.0
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	7.5	0.6	-0.6	-1.5	-1.2	-2.7	-2.2	-2.6	-1.5	-1.8	-2.1	-2.2	-0.6	-2.7	-0.6	0.5	-1.9	-1.7	1.4
Medication for cholesterol	0.5	0.7	1.9	-1.4	-0.0	-1.0	-1.3	0.2	0.1	-0.2	-1.2	-1.0	-0.6	0.4	-1.2	-0.6	-1.3	-0.6	0.1	-1.3	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.8	1.0	-0.5	-1.2	-1.1	-0.8	-1.0	-1.9	-0.9	-0.3	-0.5	-0.0	-1.1	-0.3	-0.2	0.2	0.2	-1.0	1.3
Back pain experienced in last month	0.5	0.8	3.3	-1.1	-0.1	0.8	-0.2	1.0	1.1	1.5	-0.4	-0.5	-0.1	1.1	-0.1	0.3	-1.1	-1.2	0.4	-0.3	-1.8
Mineral and other dietary supplements	1.0	1.3	4.5	-0.7	-1.9	-1.0	-1.1	-0.0	-0.0	-0.2	-0.9	-1.1	-1.0	0.4	-2.1	-0.1	-1.3	-2.0	-0.2	-1.4	-1.0
Breast cancer (self-reported)	0.5	0.6	2.7	-0.5	-1.2	-0.7	-0.8	-0.3	-0.4	-0.5	-0.8	-0.8	-0.7	0.3	-1.6	-0.2	-0.7	-0.8	-0.1	-0.9	-0.2
Asthma (self-reported)	1.6	3.3	7.7	1.9	1.5	2.7	2.8	-1.3	0.8	-0.4	1.9	2.0	1.8	-0.6	1.3	0.6	2.4	2.7	1.2	2.1	1.7
Osteoporosis (self-reported)	0.4	0.5	1.6	-1.0	-0.4	-0.4	-0.4	0.3	0.6	0.3	-0.6	-0.4	-0.2	0.7	-1.3	0.6	-0.9	-1.1	0.6	-0.8	-0.9
Osteoarthritis (self-reported)	0.7	1.0	2.2	-1.5	-1.2	-0.7	-1.2	0.3	-0.1	0.3	-1.1	-1.4	-1.1	0.0	-0.4	-0.8	-1.3	-1.4	-0.8	-1.1	-1.0
Medication: Aspirin	0.7	1.0	5.2	0.8	1.3	0.7	1.0	0.0	0.0	0.6	1.0	0.5	0.3	-1.1	2.3	-0.5	1.0	1.2	-0.9	1.2	0.4
Medication: Gliclazide	2.2	2.5	5.3	-0.0	0.9	-2.1	-1.9	-1.7	-1.8	-2.0	-1.8	-1.6	-1.6	-1.2	-2.3	-2.0	-1.1	0.2	-1.2	-1.7	1.4
Illnesses of father: None of the above (group 1)	0.3	0.4	1.6	-0.1	-1.3	0.5	0.5	0.2	0.6	-0.0	0.3	0.6	0.6	0.8	-0.7	0.9	0.3	-0.2	1.1	0.1	-0.1
Smoking status: Current	0.1	0.2	1.4	0.2	-1.2	-0.4	-0.0	-0.1	-0.5	-0.1	0.1	-0.2	-0.5	-0.8	-0.3	-0.5	0.1	-0.5	-0.8	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	5.3	-0.9	0.3	-2.0	-2.3	-1.9	-1.7	-2.0	-2.0	-1.9	-1.8	-0.7	-2.1	-1.7	-1.6	-0.7	-0.8	-2.3	0.8
Whole body water mass	0.2	1.0	2.7	0.9	1.4	-0.5	0.4	0.4	-0.8	0.3	0.8	0.7	0.3	-1.6	0.9	-1.1	1.3	1.2	-1.4	1.4	1.1
Leg predicted mass (right)	0.1	0.7	3.0	0.4	0.6	-0.9	-0.2	0.1	-1.0	0.1	0.4	0.1	-0.3	-1.7	0.3	-1.3	0.7	0.5	-1.7	0.6	0.7
Arm fat mass (left)	0.3	1.4	3.9	-1.4	-1.1	-1.1	-1.4	0.5	-0.6	0.7	-1.2	-1.3	-1.2	-0.7	-1.3	-0.9	-1.2	-2.0	-1.6	-0.9	-1.3
Number of self-reported non-cancer illnesses	0.7	1.1	3.7	1.2	-1.9	0.1	0.6	-1.6	-1.2	-1.0	0.8	-0.2	-0.9	-1.7	-0.6	-1.4	0.6	0.1	-1.5	0.0	0.8
Average weekly champagne plus white wine intake	1.2	1.6	4.1	1.7	0.5	0.8	1.7	-0.9	-0.3	-0.7	1.4	1.2	0.7	-1.1	1.8	-0.1	2.0	2.0	0.0	1.2	1.8
Miserableness	0.8	1.4	3.2	-1.6	-1.0	-0.7	-1.5	-0.6	-0.7	0.3	-1.4	-1.6	-1.3	0.1	-1.2	-0.5	-1.8	-1.5	-1.0	-1.3	-1.2
Guilty feelings	0.5	0.8	2.0	-0.9	-1.4	-0.5	-0.9	-0.3	0.1	0.3	-1.0	-1.0	-1.0	0.5	-1.1	-0.0	-1.3	-1.4	-0.4	-1.1	-1.0
Wears glasses or contact lenses	0.6	0.7	2.1	-1.2	0.1	0.8	0.3	0.4	1.0	1.3	0.3	0.2	0.3	1.2	0.1	1.1	-0.6	-1.0	0.7	0.1	-1.4
Ever taken oral contraceptive pill	0.4	0.4	1.9	0.2	-0.6	-1.1	-0.4	-0.2	-0.8	-0.2	-0.2	-0.6	-0.8	-1.0	-0.4	-0.9	-0.2	-0.2	-1.4	-0.2	0.0
Hearing aid user	1.4	1.6	6.0	-1.7	-2.3	0.2	-1.0	0.8	0.4	1.1	-1.2	-1.1	-0.7	0.9	-0.1	0.2	-1.6	-2.5	-0.0	-1.1	-2.0
Mother’s age at death	0.6	0.7	3.3	1.2	1.8	0.1	0.4	-0.3	-0.2	-0.6	0.9	0.8	0.7	0.1	-0.1	0.1	0.9	1.6	0.4	0.9	1.3
Financial situation satisfaction	0.5	0.7	2.1	0.7	0.6	-0.4	-0.3	-1.3	-1.2	-0.7	-0.6	-0.8	-0.8	-1.4	0.1	-1.0	-0.2	0.8	-1.2	-0.2	0.7
Tinnitus: Yes, now most or all of the time	2.0	2.3	6.5	-2.2	-2.3	-0.0	-1.1	1.0	0.8	1.1	-1.5	-1.0	-0.6	1.6	-1.6	0.8	-1.9	-2.6	0.8	-1.5	-2.4
Commuting to job workplace: Public transport	0.1	0.1	0.4	-0.1	0.5	-0.4	-0.3	0.2	-0.0	-0.4	0.1	0.1	0.2	0.6	0.6	0.3	0.1	0.2	0.4	0.1	0.4
Eye problems/disorders: Glaucoma	0.8	0.9	2.3	-0.6	-1.5	-0.9	-1.1	-0.4	-0.5	-0.6	-1.5	-1.2	-1.2	-0.3	-1.1	-0.5	-1.1	-1.1	-0.5	-1.5	-0.4
Medication: Blood pressure	0.2	0.5	1.0	0.0	-0.7	-1.0	-0.9	-0.3	-1.0	-0.5	-0.9	-0.8	-1.0	-0.2	0.0	-0.4	-0.6	-0.7	-0.9	-0.7	-0.1
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.5	-1.5	-1.8	-1.0	-1.9	-0.3	-0.8	-0.5	-2.1	-1.8	-1.5	0.1	-1.8	-0.4	-1.9	-1.9	-0.2	-2.1	-1.0
Supplements: Fish oil (including cod liver oil)	1.9	2.4	7.7	1.4	2.2	1.1	1.5	-0.3	-0.1	-0.3	1.6	1.7	1.4	-0.3	2.7	0.4	1.9	2.8	0.7	1.8	1.8
High cholesterol (Self-reported)	0.6	1.1	2.6	1.1	-0.2	1.5	1.6	-0.7	0.5	-0.5	1.3	1.5	1.0	-0.1	0.7	0.8	1.4	1.1	1.1	0.9	1.1
Medication: Bendroflumethiazide	1.1	1.7	5.5	1.5	0.2	-1.5	-1.2	-1.7	-1.9	-2.4	-1.6	-0.6	-0.9	-1.4	-0.4	-1.2	0.1	0.8	-0.7	-0.9	2.0
Medication: Paracetamol	0.8	1.3	4.4	-1.6	-0.7	-1.0	-1.0	0.3	-0.3	1.0	-0.5	-1.2	-1.2	-0.1	-0.8	-0.5	-1.5	-2.1	-1.3	-1.0	-1.9
Medication: Lisinopril	0.1	0.1	0.7	0.0	0.4	-0.2	-0.1	-0.0	-0.6	0.1	0.4	0.0	-0.2	-0.4	-0.1	-0.5	0.1	0.0	-0.8	0.4	-0.2
Medication: Atorvastatin	1.3	1.6	4.7	2.2	-0.4	-0.7	-0.0	-1.9	-1.6	-1.7	0.3	0.0	-0.6	-1.9	-0.3	-1.5	1.0	1.1	-1.3	-0.0	2.1
Illnesses of father: High blood pressure	0.5	0.6	2.5	0.5	1.5	-1.0	-0.5	-0.3	-0.9	-1.2	-0.4	0.3	0.4	0.1	-0.5	-0.4	0.5	1.3	0.4	0.3	1.6
Alcohol drinker status: Never	0.4	0.5	2.7	-1.6	-0.1	0.6	0.1	0.7	1.0	1.2	0.7	-0.2	0.2	0.3	0.5	0.2	-0.3	-0.6	-0.1	0.2	-1.1
Ever smoked	0.4	0.6	3.1	-0.3	-1.8	-0.2	-0.3	0.4	0.0	0.9	-0.5	-0.6	-0.7	-0.1	-0.5	-0.1	-0.5	-1.6	-0.9	-0.3	-1.3
Basal metabolic rate	0.1	0.7	2.9	0.5	1.0	-0.8	-0.0	0.3	-1.0	0.2	0.3	0.2	-0.1	-1.7	0.5	-1.3	0.9	0.7	-1.6	0.9	0.8
Leg fat percentage (left)	0.2	0.9	2.9	-1.0	-0.8	-0.5	-1.1	0.4	-0.2	0.6	-1.3	-1.0	-0.7	0.5	-1.2	0.2	-1.2	-1.7	-0.3	-0.9	-1.2
Arm fat-free mass (left)	0.2	0.9	2.4	0.8	1.5	-0.8	-0.0	0.3	-1.1	0.0	0.4	0.3	0.1	-1.6	0.7	-1.2	1.0	1.1	-1.5	1.0	1.0
Number of operations (self-reported)	1.8	2.7	8.2	1.1	-0.5	-1.3	-1.0	-2.7	-2.4	-2.9	-1.1	-1.1	-1.6	-1.6	-2.2	-1.6	-0.2	0.6	-1.4	-1.4	1.8
Average weekly beer plus cider intake	0.3	0.5	2.6	-0.0	1.6	0.4	0.2	1.2	0.7	0.7	0.3	0.5	0.7	0.2	0.9	0.7	0.4	0.7	0.4	0.8	-0.0
Irritability	1.7	2.9	6.4	0.6	-0.8	-2.4	-2.5	-1.8	-2.4	-2.1	-2.1	-1.6	-1.8	-1.1	-0.8	-2.3	-1.1	-0.4	-1.6	-1.8	1.2
Risk taking	0.7	1.0	3.6	-1.1	-1.1	-0.3	-1.0	1.0	0.5	1.3	-0.7	-0.7	-0.2	1.2	-0.6	0.7	-1.3	-1.9	0.3	-0.7	-1.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.5	1.6	1.5	-0.1	0.5	-0.5	-0.6	-0.5	0.8	0.6	0.5	-0.2	-0.1	0.2	1.0	1.4	-0.0	0.9	1.3
Fractured/broken bones in last 5 years	0.6	0.8	2.0	-0.8	-0.3	1.2	0.7	1.3	1.4	1.3	0.3	0.9	1.0	0.7	0.2	1.1	0.2	-0.4	1.2	0.7	-0.9
Age started oral contraceptive pill	0.3	0.4	1.7	0.1	-0.4	0.5	0.2	-1.0	-0.1	-1.3	-0.6	-0.3	-0.2	0.4	0.2	0.2	-0.3	0.2	1.2	-1.0	0.3
Diastolic blood pressure, automated reading	0.5	1.6	5.1	-1.5	-2.3	-1.5	-1.2	0.5	-0.9	0.4	-0.7	-1.0	-1.4	-0.9	-0.6	-1.2	-1.0	-2.0	-1.8	-0.9	-1.2
Ever depressed for a whole week	0.3	0.4	1.4	-0.9	0.2	-0.8	-0.9	-0.4	0.0	-0.3	-1.2	-0.9	-0.5	0.2	-0.5	-0.2	-1.1	-0.3	0.0	-0.6	-0.3
Unable to work because of sickness or disability	1.3	1.6	6.4	-1.3	-0.2	0.3	-0.6	2.2	1.1	2.4	-0.2	-0.4	0.2	1.4	-0.6	1.1	-1.2	-1.9	0.4	-0.0	-2.5
Commuting to job workplace: Cycle	0.4	0.5	2.7	0.5	0.2	0.2	0.2	-1.1	-0.5	-1.7	-0.3	-0.0	-0.1	-0.6	-1.0	-0.8	0.4	1.0	0.2	-0.1	1.1
Myopia	1.1	1.7	3.4	1.6	1.2	1.4	1.7	-0.3	0.3	-0.0	1.7	1.6	1.4	-0.2	1.2	0.7	1.8	1.9	0.6	1.8	1.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.1	-0.4	1.1	-0.4	-0.7	0.4	0.1	-0.2	-0.9	-0.0	0.3	0.8	-0.9	0.1	-0.4	0.2	0.9	-0.4	0.1
Cholesterol lowering medication	1.2	1.8	4.4	1.2	0.5	2.1	1.8	-0.3	0.9	0.1	1.5	1.8	1.6	0.6	1.0	1.6	1.6	1.4	1.7	1.3	1.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	0.4	0.1	0.1	-0.3	0.1	0.2	-0.1	-0.3	0.2	0.4	0.5	-0.3	0.5	-0.1	-0.0	0.6	0.0	0.1
Pain experienced in last month	0.6	0.9	3.4	0.5	1.8	0.8	1.1	0.6	0.9	0.2	1.2	1.1	1.3	0.5	0.5	0.7	0.9	1.2	1.1	1.0	0.4
Supplements: Calcium	0.2	0.2	0.8	0.5	0.9	-0.4	-0.2	-0.0	-0.6	0.2	-0.2	0.2	-0.1	-0.8	0.2	0.1	0.4	0.6	-0.9	0.4	0.6
Basal cell carcinoma (self-reported)	1.2	1.5	4.0	-1.6	-0.1	-0.3	-0.4	2.0	1.4	1.9	0.2	0.2	0.7	1.8	-0.3	1.5	-0.8	-1.7	0.8	0.2	-1.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	0.7	-0.3	-0.0	0.4	0.6	0.5	0.8	1.0	0.5	0.6	0.6	1.0	0.9	0.4	0.1	0.3	0.7	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.7	0.4	-0.7	-0.8	-0.7	0.2	-0.5	-0.3	-0.4	-0.3	-0.3	-0.7	-0.4	-0.2	0.1	-0.1	-0.7	0.1	0.6
Heart disease (siblings)	1.0	1.2	3.6	1.9	1.9	0.1	0.6	-0.9	-0.5	-0.9	0.6	0.5	0.4	-0.8	1.6	-0.3	1.0	1.9	-0.3	0.8	1.6
Alcohol drinker status: Previous	0.8	0.9	2.4	0.9	-0.2	1.0	1.0	0.9	0.7	0.9	1.5	1.4	1.1	0.2	0.5	0.6	1.3	0.7	0.4	1.5	0.3
Pack years of smoking	0.4	0.6	1.7	1.1	0.2	-0.8	-0.1	-0.2	-0.9	-0.5	0.9	0.9	0.4	-0.4	1.0	-0.8	1.1	1.0	-0.4	0.8	1.3
Impedance of whole body	0.4	1.9	4.4	-0.3	-1.9	-1.4	-1.3	-1.8	-1.3	-1.8	-1.9	-1.5	-1.6	-0.5	-2.1	-0.4	-1.2	-1.0	-0.6	-1.8	0.2
Leg fat mass (left)	0.2	0.9	2.4	-1.0	-0.5	-0.8	-1.2	0.5	-0.4	0.8	-1.2	-1.1	-0.9	-0.3	-1.0	-0.5	-1.1	-1.6	-1.1	-0.7	-1.1
Arm predicted mass (left)	0.2	0.8	2.9	0.7	1.2	-1.0	-0.3	0.1	-1.3	-0.1	0.2	0.1	-0.2	-1.7	0.4	-1.4	0.8	0.8	-1.7	0.8	0.9