Hub : Genes

RP11-53O19.1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue 0.0610 0.0300 4.8e-03 0.064 NA 0.014 NA 0.031 3.3e-04 NA 6.3e-02 NA 1.0e-02
2 GTEx Breast Mammary Tissue (Female) 0.0625 0.0422 6.1e-02 -0.009 NA -0.010 NA 0.001 7.5e-01 NA 9.1e-01 NA 3.0e-01
3 GTEx Heart Atrial Appendage 0.1700 0.0570 3.5e-07 0.168 NA 0.144 NA 0.171 5.1e-08 NA 5.1e-07 NA 3.8e-08
4 GTEx Heart Left Ventricle 0.1277 0.0463 6.1e-08 0.219 NA 0.178 NA 0.208 6.8e-12 NA 9.1e-10 NA 2.5e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.9 3.0 5.1 1.1 0.7 -2.3 -2.2
Bipolar Disorder or Schizophrenia 6.0 14.6 21.0 3.5 2.4 -4.4 -4.6
Depressed Affect (Nagel 2018) 1.3 2.7 8.1 -0.0 -2.9 1.0 1.3
Depression (Nagel 2018) 3.3 4.9 17.0 1.2 -4.1 0.7 0.8
Intelligence (Savage-Jansen 2018) 2.0 6.1 13.9 -3.7 1.6 2.0 2.0
Neuroticism (Nagel 2018) 1.6 3.7 10.1 -0.2 -3.2 1.5 1.6
Schizophrenia (2018) 6.1 12.7 16.8 3.5 2.6 -3.9 -4.1
Schizophrenia vs Biploar Disorder 1.9 2.5 3.5 0.9 1.7 -1.9 -1.7
Worry (Nagel 2018) 0.6 1.2 3.5 -0.1 -1.9 0.7 0.8
Alzheimer’s Disease (in mother) 1.3 1.5 1.9 1.4 0.6 -1.4 -1.4
Alzheimer’s Disease (in father) 0.9 0.9 2.3 -0.1 1.5 -0.9 -0.8
Alzheimer’s Disease (including proxy) 2.0 2.8 4.9 1.2 0.9 -2.2 -2.1
Crohns Disease (2017) 1.1 2.5 3.5 1.8 0.1 -1.8 -1.9
Irritable Bowel Disease (IBD) 1.0 2.4 3.4 1.0 1.4 -1.8 -1.8
Ulcerative Colitis (UC) 0.6 1.1 3.5 -0.2 1.9 -0.7 -0.7
Major Depression (MDD) 1.6 1.9 4.9 2.2 -1.4 -0.4 -0.7
Reaction Time 0.4 0.7 1.8 1.3 -0.4 -0.6 -0.8
Verbal and Numeric Reasoning (VNR) 0.8 1.9 4.2 -2.0 0.6 1.3 1.1
Breast Cancer 66.8 160.8 259.2 -16.1 -3.8 13.4 13.8
Ovarian Cancer 1.3 1.7 2.5 1.6 -0.2 -1.4 -1.6
Prostate Cancer 0.8 1.2 2.6 0.3 0.6 -1.6 -1.3
Age at First Birth 6.5 9.5 26.2 -0.3 5.1 -2.5 -2.3
Bipolar Disorder (2011) 1.5 1.5 2.8 -0.2 1.7 -1.2 -1.3
Body Mass Index (BMI) (2010) 1.2 1.7 3.8 1.9 -1.3 -0.8 -0.6
Coronary Artery Disease (CAD) 2.2 2.7 4.8 2.2 0.3 -1.8 -1.6
Crohns Disease (2012) 1.0 1.6 2.4 1.2 0.5 -1.5 -1.6
Mean Putamen Volume 1.1 1.3 2.9 0.0 1.7 -0.9 -1.1
Fasting Glucose 0.3 0.4 0.5 0.7 0.7 -0.2 -0.7
HbA1C 0.5 0.5 1.5 0.0 1.2 -0.7 -0.3
HDL Cholesterol 1.2 1.9 3.1 -1.5 -0.6 1.5 1.8
LDL Cholesterol 1.4 2.2 3.5 1.9 1.2 -1.3 -1.5
Lupus 0.0 0.0 0.1 0.2 -0.2 -0.1 -0.1
Neuroticism (2016) 0.7 1.0 3.6 0.1 -1.9 0.6 0.4
Primary Biliary Cirrhosis 0.2 0.3 0.5 0.3 0.6 -0.6 -0.7
Rheumatoid Arthritis 0.2 0.3 0.6 0.8 -0.5 0.3 0.2
Schizophrenia (2014) 5.5 12.2 18.8 3.2 2.0 -4.0 -4.3
Triglycerides 2.9 4.7 6.0 1.9 2.2 -2.1 -2.4
Type 2 Diabetes (T2D) (2012) 1.3 1.5 3.1 0.2 0.6 -1.8 -1.5
Ulcerative Colitis 0.9 1.4 3.5 -0.0 1.9 -1.0 -1.0
Blood Eosinophil Count 0.1 0.6 1.0 -1.0 -0.5 0.9 0.7
Blood Platelet Count 0.2 1.8 3.3 -1.0 -0.6 1.8 1.6
Blood Red Count 0.2 2.3 6.5 -1.4 2.5 -0.6 -0.8
Blood White Count 0.2 1.2 3.5 -0.8 1.9 0.6 0.6
Heel T-Score 0.2 1.8 4.7 0.3 -2.2 1.2 1.0
BMI 0.5 3.0 6.5 -0.2 -2.5 1.6 1.6
Height 0.5 9.3 24.2 0.9 4.9 -2.3 -2.6
Waist Hip Ratio (WHR) 1.0 4.5 7.1 1.7 1.1 -2.6 -2.7
Systolic Blood Pressure 0.8 4.2 7.8 0.3 1.3 -2.7 -2.8
Smoking Status 2.3 5.4 8.0 -1.3 -2.2 2.8 2.7
Allergy or Eczema 2.0 5.3 9.4 -0.9 3.1 -2.4 -2.2
Cardiovascular Disease 0.4 1.4 2.8 -1.0 1.7 -0.9 -1.0
Hypothyroidism (self reported) 0.2 0.4 1.2 0.5 -1.1 0.1 0.0
Respiratory disease 0.8 1.9 3.9 2.0 1.2 -1.0 -1.1
Type 2 Diabetes (T2D) (2018) 3.0 5.6 9.3 0.2 3.1 -2.5 -2.6
Lung FEV1/FVC ratio 1.3 6.5 11.5 -1.9 -0.5 3.4 3.3
Lung FVC 0.5 2.5 3.5 -1.8 -1.0 -1.9 -1.4
Neuroticism 0.9 2.1 6.9 0.5 -2.6 0.7 0.8
Chronotype (morning person) 0.1 0.3 0.9 1.0 0.4 -0.1 -0.1
Hair Pigment 0.1 2.6 4.8 -0.2 -2.2 1.8 1.5
Tanning 0.0 0.3 0.6 0.8 -0.8 -0.4 -0.1
Hand grip strength (left) 1.6 4.1 15.2 -0.9 3.9 -0.4 -0.6
Number of treatments/medications taken 0.2 0.3 0.4 -0.6 0.5 -0.7 -0.4
Average weekly spirits intake 0.6 0.8 1.2 -1.0 -0.4 1.0 1.1
Sensitivity / hurt feelings 4.0 6.9 10.2 -1.1 -2.7 3.2 2.9
Frequency of depressed mood in last 2 weeks 2.6 3.6 10.9 1.8 -3.3 -0.3 -0.0
Hearing difficulty/problems: Yes 0.4 0.7 1.1 -0.9 -0.1 1.0 0.9
Relative age of first facial hair 1.5 3.1 4.8 -2.0 0.1 2.2 2.0
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 4.3 2.1 -0.3 -1.5 -1.3
Ever used hormone-replacement therapy (HRT) 0.8 1.0 3.0 0.7 -1.7 0.5 0.5
Ever had hysterectomy (womb removed) 1.5 1.7 2.1 -1.5 -1.3 1.0 1.4
Systolic blood pressure, automated reading 0.3 0.8 1.3 -1.0 -0.1 -1.1 -1.0
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.2 0.2 0.4 -1.0 -1.1
Angina 2.4 3.2 5.0 -1.2 -2.2 1.9 1.6
Medication for hormone replacement therapy 0.6 0.7 1.2 -1.1 -0.4 0.8 0.7
Vitamin and mineral supplements 0.2 0.2 0.3 -0.4 -0.5 0.6 0.4
Supplements: Zinc 0.9 0.9 1.9 1.4 -0.3 -0.9 -1.0
Medication: Co-codamol 3.4 4.0 6.4 -0.9 -2.5 2.2 1.9
Medication: Metformin 5.9 8.3 12.8 1.9 2.0 -3.6 -3.6
Diabetes (father) 1.0 1.2 1.7 -0.2 1.3 -1.3 -1.1
Diabetes (mother) 1.8 2.2 7.1 -0.9 2.7 -0.8 -0.7
Severe depression (siblings) 2.6 3.0 4.4 2.0 0.5 -2.1 -1.8
Pack years adult smoking proportion 0.8 1.3 4.8 0.3 -2.2 0.3 0.4
Impedance of leg (right) 0.5 2.4 4.2 0.8 1.0 -1.9 -2.0
Leg fat-free mass (left) 0.1 0.3 0.6 -0.1 0.8 0.5 0.5
Trunk fat percentage 0.4 1.4 2.5 -1.6 -1.4 0.8 0.7
Hand grip strength (right) 1.7 4.6 12.6 0.1 3.6 -1.5 -1.8
Townsend deprivation index at recruitment 1.9 2.7 3.6 1.9 -0.7 -1.9 -1.8
Current tobacco smoking 1.2 2.0 2.6 1.4 -1.6 1.4 1.2
Average weekly fortified wine intake 0.3 0.4 0.9 0.7 -1.0 -0.0 -0.1
Maternal smoking around birth 1.6 2.3 9.0 0.5 -3.0 -0.1 0.0
Fed-up feelings 3.2 5.8 11.3 -0.2 -3.4 2.4 2.4
Frequency of unenthusiasm / disinterest in last 2 weeks 2.6 3.4 12.7 1.0 -3.6 0.2 0.2
Relative age voice broke 0.4 0.7 1.2 -0.8 0.1 1.1 0.9
Taking other prescription medications 0.1 0.1 0.3 0.0 0.5 -0.3 -0.2
Age when periods started (menarche) 0.1 0.3 0.7 -0.5 0.0 0.8 0.5
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.6 -1.3 -0.6 0.4 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 2.6 0.8 -1.6 0.6 0.6
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.1 0.2 -0.1 -0.1 -0.3
Qualifications: CSEs or equivalent 1.1 1.5 2.3 0.2 1.2 -1.5 -1.5
Serious illness, injury or assault to yourself 0.4 0.5 1.2 1.1 0.0 -0.6 -0.7
High blood pressure 0.4 1.1 1.7 -1.3 0.4 -1.2 -1.1
Hayfever, allergic rhinitis or eczema 2.6 5.6 9.9 -0.8 3.1 -2.6 -2.3
Multivitamins +/- minerals 0.6 0.7 1.1 1.0 -0.2 -1.1 -0.9
Stomach or abdominal pain in last month 0.4 0.4 1.3 1.1 -0.7 -0.1 -0.2
Supplements: Glucosamine 0.2 0.2 0.8 0.2 0.9 0.0 0.2
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.3 -0.4 0.3 0.5 0.4
Medication: Atenolol 0.1 0.1 0.2 -0.4 -0.2 0.3 0.1
Medication: Levothyroxine sodium 0.9 1.4 2.4 -1.5 -0.8 1.1 1.3
Sitting height 0.7 5.0 7.1 1.7 2.7 -2.1 -2.3
Chronic bronchitis/emphysema (father) 0.1 0.1 0.5 -0.7 -0.4 0.0 0.0
High blood pressure (mother) 1.2 1.6 4.4 0.5 2.1 -1.0 -1.0
Body mass index (BMI) 0.7 3.2 7.7 -0.4 -2.8 1.5 1.6
Impedance of leg (left) 0.5 2.7 4.5 1.1 1.0 -2.0 -2.1
Leg predicted mass (left) 0.1 0.3 0.6 -0.1 0.7 0.5 0.5
Trunk fat mass 0.2 1.0 1.5 -1.1 -1.2 0.8 0.7
Waist circumference 0.0 0.2 0.5 0.4 -0.7 -0.1 -0.1
Number of incorrect matches in round 0.2 0.3 0.9 0.9 -0.4 -0.0 -0.3
Past tobacco smoking 1.4 2.6 3.0 1.7 1.5 -1.7 -1.5
Alcohol usually taken with meals 1.4 2.2 3.9 1.3 2.0 -1.1 -1.4
Nervous feelings 0.1 0.2 0.4 -0.3 0.6 0.5 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 3.8 1.0 -2.0 0.1 0.1
Hearing difficulty/problems with background noise 0.1 0.2 0.5 -0.7 -0.5 0.3 0.3
Hair/balding pattern: Pattern 2 0.2 0.3 0.5 0.2 -0.7 -0.3 -0.7
Had menopause 0.0 0.0 0.1 0.0 -0.1 -0.0 0.2
Had other major operations 0.6 0.7 1.8 1.4 -0.1 -0.6 -0.7
Forced vital capacity (FVC) 0.7 2.8 4.3 -0.3 2.1 -1.8 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.3 0.3 -1.5 1.0 0.9
Ever unenthusiastic/disinterested for a whole week 6.5 8.0 11.8 3.4 0.9 -3.0 -3.3
Qualifications: None of the above 1.5 3.3 11.7 0.5 -3.4 0.6 0.8
Financial difficulties in last 2 years 0.3 0.4 1.1 0.4 0.0 -1.0 -0.7
Mouth/teeth dental problems 0.8 1.2 2.4 -1.6 -0.3 1.1 1.1
Heart attack 2.1 2.6 4.3 -0.9 -2.1 1.7 1.6
Allergy 2.5 5.8 8.8 -0.4 -2.6 3.0 2.7
Pain all over the body in last month 0.3 0.4 0.6 0.4 -0.8 0.5 0.6
Diabetes (self-reported) 0.9 1.5 2.1 0.3 1.5 -1.3 -1.3
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 3.3 0.9 1.4 -1.8 -1.5
Medication: Ramipril 1.2 1.5 4.5 -0.9 2.1 -0.5 -0.7
Medication: Simvastatin 0.0 0.0 0.1 0.2 0.0 0.0 -0.3
Fluid intelligence score 2.0 4.1 8.3 -2.9 0.2 2.1 1.9
Illnesses of siblings 0.1 0.1 0.4 0.6 -0.3 0.2 -0.0
Neuroticism score 1.1 2.4 7.1 0.0 -2.7 1.1 1.1
Weight 0.0 0.2 0.4 0.1 -0.4 0.6 0.6
Impedance of arm (right) 0.5 2.5 3.9 -0.4 1.7 -1.7 -2.0
Arm fat percentage (right) 0.7 2.8 6.8 -1.2 -2.6 1.2 1.2
Trunk fat-free mass 0.2 0.9 2.2 1.2 1.5 -0.1 -0.0
Hip circumference 0.2 0.7 1.0 -0.1 -1.0 0.9 0.9
Time employed in main current job 1.9 2.2 7.7 -2.8 -0.1 0.6 0.9
Alcohol intake versus 10 years previously 0.2 0.4 0.9 0.2 -1.0 -0.5 -0.4
Father’s age at death 0.6 0.9 1.6 -1.3 0.0 0.8 1.1
Worrier / anxious feelings 0.2 0.4 1.2 -0.5 -1.1 0.3 0.4
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 3.6 1.6 -1.9 -0.2 -0.0
Falls in the last year 0.9 1.2 2.1 1.5 -0.0 -1.2 -1.1
Hair/balding pattern: Pattern 3 0.5 0.7 2.1 -0.8 1.4 -0.2 -0.2
Number of live births 0.7 1.1 1.7 0.5 -1.2 0.9 1.3
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 2.8 -0.4 1.7 -1.2 -1.2
Pulse rate 1.9 3.1 4.4 1.5 1.5 -1.9 -2.1
Happiness 1.6 1.9 3.0 0.8 1.7 -1.3 -1.5
Noisy workplace 1.4 1.8 3.3 1.8 -0.3 -1.4 -1.3
Qualifications: A levels/AS levels or equivalent 0.2 0.5 0.8 -0.5 0.4 0.9 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.1 0.0 0.3 -0.4 -0.3
Mouth/teeth dental problems: Dentures 1.4 2.4 8.0 2.8 -1.1 -0.1 -0.6
Asthma 0.6 1.2 2.7 1.2 1.6 -0.7 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.9 1.0 -1.7 0.2 0.5
Medication: Cholesterol lowering 0.4 0.7 1.4 -1.2 -1.1 0.2 0.1
Depression (self-reported) 1.0 1.2 2.9 1.1 -1.7 -0.6 -0.6
Medication: Lansoprazole 1.2 1.4 2.6 -1.6 0.2 1.1 1.3
Prospective memory result 0.7 0.8 2.2 1.0 -1.5 0.0 0.0
Lung cancer (father) 1.6 1.9 2.2 1.5 1.1 -1.4 -1.5
Illnesses of mother 0.1 0.2 0.6 0.8 -0.1 0.3 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 4.4 0.2 1.9 -1.9 -2.1
Pulse wave Arterial Stiffness index 0.2 0.3 0.6 0.8 -0.6 0.2 0.2
Impedance of arm (left) 0.4 2.0 3.5 -0.8 1.9 -1.2 -1.5
Arm fat mass (right) 0.4 1.8 3.9 -0.8 -2.0 1.1 1.2
Trunk predicted mass 0.2 0.9 2.0 1.2 1.4 -0.1 -0.0
Standing height 0.9 9.0 25.8 1.0 5.1 -2.0 -2.3
Length of working week for main job 2.1 2.3 3.2 -1.2 -1.8 1.3 1.7
Exposure to tobacco smoke at home 0.7 0.8 1.5 0.2 -1.2 -1.1 -0.6
Breastfed as a baby 0.7 0.8 2.1 1.0 1.5 0.0 -0.3
Tense / ‘highly strung’ 1.2 2.0 5.9 1.0 -2.4 -0.9 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 3.1 -0.1 -1.8 0.3 0.2
Hair/balding pattern: Pattern 4 0.7 1.7 5.1 2.3 -0.1 -0.8 -1.0
Birth weight of first child 0.2 0.3 0.8 0.0 0.0 0.9 0.8
Peak expiratory flow (PEF) 0.3 0.7 1.4 -0.1 0.4 -1.2 -1.1
Pulse wave reflection index 0.9 1.2 1.6 0.6 -1.1 1.3 1.2
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 0.3 -0.1 0.4 0.4
Loud music exposure frequency 5.5 6.0 10.0 1.3 1.7 -3.2 -3.1
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.5 -0.8 1.2 0.2 0.2
Mouth/teeth dental problems: Bleeding gums 1.5 2.0 3.5 -0.5 1.5 -1.9 -1.4
Blood clot in the leg (DVT) 0.7 0.9 3.5 -0.0 -1.9 0.1 0.1
Medication: Paracetamol 0.4 0.7 1.1 -0.3 -1.1 0.9 1.0
Headache pain in last month 1.9 3.3 5.3 -0.6 -2.3 1.9 2.0
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.8 1.3 0.3 0.3 0.4
Glaucoma (self-reported) 1.2 1.4 3.1 0.1 0.4 -1.8 -1.5
Gout (self-reported) 0.1 0.2 0.7 0.2 0.9 -0.1 -0.0
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 1.9 -0.7 -0.9 1.2 1.4
Medication: Amlodipine 0.1 0.2 0.6 -0.3 0.8 0.2 0.2
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.3 0.5 0.1 -0.3 -0.3
Birth weight 2.2 4.9 8.6 -1.5 -1.0 2.9 2.7
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.2 -0.3 -1.1 0.9 1.1
High blood pressure (siblings) 0.7 1.0 2.4 -1.5 -0.5 0.8 1.0
Forced vital capacity (FVC), Best measure 1.2 4.3 6.8 0.5 2.1 -2.3 -2.6
Body fat percentage 0.5 1.9 4.4 -1.2 -2.1 1.0 1.0
Leg fat percentage (right) 1.0 3.6 10.2 -0.6 -3.2 1.3 1.5
Arm fat-free mass (right) 0.1 0.3 0.5 0.4 0.7 0.5 0.5
Exposure to tobacco smoke outside home 0.3 0.4 0.9 0.2 -1.0 -0.6 -0.5
Comparative body size at age 10 0.5 1.5 3.2 -0.6 -1.8 1.1 1.1
Number of full brothers 1.3 1.7 2.8 0.0 -1.1 1.7 1.6
Worry too long after embarrassment 1.5 2.4 3.3 -1.3 -1.3 1.8 1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 2.2 2.9 6.5 2.5 -0.7 -1.4 -1.6
Wheeze or whistling in the chest in last year 1.7 3.0 4.8 -1.0 -1.5 1.9 2.2
Number of children fathered 4.4 5.0 7.6 -1.6 -1.6 2.7 2.8
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.4 0.4 -0.4 -0.6 -0.5
Age at first live birth 2.2 3.9 11.9 -1.4 3.5 -1.0 -0.9
Pulse wave peak to peak time 0.4 0.4 1.0 -0.7 1.0 -0.3 -0.3
Health satisfaction 2.6 3.4 5.0 2.2 0.6 -1.9 -2.2
Shortness of breath walking on level ground 4.3 5.2 8.6 -1.7 -1.6 2.9 2.6
Qualifications: College or University degree 0.5 1.6 2.0 -1.4 1.4 1.3 0.9
Eye problems/disorders: None of the above 1.4 1.7 2.2 -1.4 0.6 1.4 1.5
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.9 -0.1 -0.6 -1.4 -1.2
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.0 -0.4 -0.2 -0.2
Medication for pain relief, constipation, heartburn 1.0 1.6 4.8 0.3 2.2 -0.9 -0.9
Neck or shoulder pain in last month 0.4 0.5 1.7 0.2 -1.3 -0.5 -0.4
Medication: Blood pressure 0.3 0.6 2.3 -1.5 -0.1 0.2 0.1
Angina (self-reported) 2.8 3.7 5.5 -1.4 -2.4 2.0 1.8
Migraine (self-reported) 1.9 2.3 3.1 -1.8 -1.1 1.4 1.7
Medication: Ibuprofen 0.2 0.2 0.4 0.5 -0.7 -0.2 0.1
Medication: Allopurinol 0.3 0.4 0.6 0.7 0.1 -0.8 -0.7
Medication: Omeprazole 0.3 0.4 0.8 0.4 0.2 -0.9 -0.7
Medication: Seretide 50 evohaler 0.7 0.8 1.3 0.3 0.9 -1.0 -1.1
Mean time to correctly identify matches 0.2 0.3 1.0 0.3 -1.0 0.3 0.1
Heart disease (mother) 0.2 0.3 0.6 -0.0 -0.8 -0.5 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.1 -0.6 -0.4 1.4 1.4
Whole body fat mass 0.4 1.5 2.8 -0.9 -1.7 1.0 1.1
Leg fat mass (right) 0.6 2.2 5.9 -0.5 -2.4 1.1 1.2
Arm predicted mass (right) 0.1 0.3 0.6 0.4 0.8 0.5 0.6
Pulse rate, automated reading 5.1 16.5 25.2 2.6 3.4 -4.8 -5.0
Alcohol intake frequency. 0.7 1.6 3.5 1.9 -0.6 -1.1 -1.1
Comparative height size at age 10 0.6 3.2 8.6 0.5 2.9 -1.2 -1.5
Number of full sisters 1.5 1.8 3.1 1.4 -0.7 -1.8 -1.4
Suffer from ‘nerves’ 0.3 0.5 0.8 0.8 -0.3 -0.9 -0.8
Overall health rating 1.8 3.8 10.1 3.2 0.1 -1.5 -1.7
Chest pain or discomfort 1.5 2.1 6.3 -0.1 -2.5 1.0 1.0
Had major operations 2.7 3.2 4.6 -0.8 -2.2 1.9 2.0
Age at last live birth 1.7 2.5 6.0 -1.5 2.5 -1.0 -0.8
Family relationship satisfaction 0.2 0.2 0.3 -0.5 0.4 -0.2 -0.6
Leg pain on walking 0.2 0.2 0.4 -0.3 0.5 -0.4 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 0.3 0.1 -0.2 -0.4
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.7 -1.3 -0.3 0.9 0.8
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.3 -0.5 -0.6 0.5 0.3
Medication: Aspirin 0.6 0.8 1.9 -0.9 -1.4 0.7 0.4
Supplements: Vitamin C 0.7 0.8 1.3 1.1 0.7 -0.9 -0.8
Knee pain experienced in last month 0.2 0.3 1.1 -0.2 1.0 -0.2 -0.1
Hypertension (Self-reported) 0.4 1.1 1.8 -0.9 0.5 -1.3 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.1 0.3 -0.2 0.1 0.1
Illnesses of father: Heart disease 0.1 0.2 0.7 0.3 -0.8 -0.1 -0.1
Illnesses of siblings: Diabetes 0.4 0.5 0.9 -0.8 0.9 0.3 0.6
Smoking status: Previous 1.0 1.5 4.6 -2.1 -0.2 0.8 0.8
Forced expiratory volume in 1-second (FEV1), predicted 2.0 4.1 6.1 1.6 2.5 -1.8 -2.1
Whole body fat-free mass 0.1 0.5 1.5 0.7 1.2 0.2 0.2
Leg fat-free mass (right) 0.1 0.4 1.0 0.0 1.0 0.6 0.5
Arm fat percentage (left) 0.7 2.6 6.0 -1.2 -2.5 1.2 1.3
Average weekly red wine intake 0.5 0.8 1.5 -0.8 0.2 1.2 1.1
Handedness (chirality/laterality): Left-handed 0.8 1.0 1.2 1.1 -0.9 1.1 0.9
Mood swings 0.9 1.6 5.4 0.9 -2.3 0.2 0.2
Loneliness, isolation 1.1 1.6 4.7 -1.1 -2.2 0.4 0.6
Long-standing illness, disability or infirmity 2.2 3.4 5.0 1.9 -0.8 -2.2 -2.1
Ever had bowel cancer screening 0.4 0.5 1.8 -1.3 0.4 0.0 0.2
Diabetes diagnosed by doctor 2.4 3.9 5.7 0.8 1.9 -2.4 -2.4
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.0 5.4 1.2 -2.3 0.7 0.8
Friendships satisfaction 1.0 1.3 2.3 1.0 1.0 -0.9 -1.5
Qualifications: nursing, teaching 0.1 0.2 0.3 0.5 -0.4 0.4 0.4
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.0 -0.5 0.3 0.1
Eye problems/disorders: Cataract 0.1 0.1 0.2 0.4 -0.0 -0.4 -0.5
Mouth/teeth dental problems: Mouth ulcers 2.5 3.9 5.8 -1.7 -1.4 2.2 2.4
Medication for cholesterol 0.5 0.8 1.0 1.0 0.9 -0.8 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.5 0.6 -0.3 -0.7 -0.6
Back pain experienced in last month 1.6 2.4 3.9 -1.4 -0.6 2.0 1.8
Mineral and other dietary supplements 1.8 2.5 3.8 -1.1 -1.3 2.0 1.8
Breast cancer (self-reported) 16.1 19.2 23.4 4.7 3.0 -4.8 -4.8
Asthma (self-reported) 0.3 0.6 1.4 1.0 1.2 -0.3 -0.3
Osteoporosis (self-reported) 1.1 1.4 3.7 -0.8 -1.9 0.8 0.8
Osteoarthritis (self-reported) 1.2 1.5 3.3 -1.8 0.9 1.0 1.0
Medication: Aspirin 0.4 0.5 1.0 -0.7 -1.0 0.6 0.3
Medication: Gliclazide 3.3 3.7 6.1 1.5 0.7 -2.5 -2.5
Illnesses of father: None of the above (group 1) 0.2 0.2 0.5 0.4 0.0 0.7 0.5
Smoking status: Current 1.1 1.7 2.1 1.5 -1.4 1.2 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.5 5.2 -0.1 0.4 -2.3 -2.2
Whole body water mass 0.1 0.5 1.3 0.6 1.1 0.3 0.3
Leg predicted mass (right) 0.1 0.3 0.7 0.0 0.9 0.6 0.6
Arm fat mass (left) 0.5 2.0 3.9 -0.7 -2.0 1.3 1.4
Number of self-reported non-cancer illnesses 1.2 2.1 4.2 0.4 0.1 -2.0 -2.0
Average weekly champagne plus white wine intake 0.9 1.3 2.7 0.2 -0.2 -1.5 -1.6
Miserableness 1.2 2.0 4.7 2.2 -1.3 -1.1 -0.8
Guilty feelings 1.6 2.5 5.3 -0.8 -2.3 1.4 1.4
Wears glasses or contact lenses 0.2 0.2 0.5 0.3 -0.7 -0.3 -0.2
Ever taken oral contraceptive pill 0.1 0.2 0.2 -0.4 0.4 -0.3 -0.4
Hearing aid user 3.2 3.6 5.6 -0.0 -2.0 2.4 2.2
Mother’s age at death 0.6 0.7 1.6 -1.3 0.4 0.8 0.8
Financial situation satisfaction 0.5 0.6 1.2 0.3 0.4 -1.0 -1.1
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.2 -0.1 1.5 -0.3 -0.5
Commuting to job workplace: Public transport 0.4 0.5 0.8 -0.5 0.4 0.8 0.9
Eye problems/disorders: Glaucoma 0.6 0.7 1.5 -0.3 0.3 -1.2 -1.1
Medication: Blood pressure 0.2 0.4 1.2 -0.6 1.1 0.2 0.1
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.1 0.1 -0.2 0.2 0.2
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.4 0.3 0.5 -0.6 -0.6
High cholesterol (Self-reported) 0.2 0.4 1.4 -1.2 -0.2 0.3 0.2
Medication: Bendroflumethiazide 0.0 0.1 0.1 0.3 -0.1 0.3 0.3
Medication: Paracetamol 1.0 1.5 2.5 -1.1 -0.7 1.4 1.6
Medication: Lisinopril 1.5 1.9 2.3 -1.1 -1.5 1.5 1.4
Medication: Atorvastatin 0.7 0.9 3.2 -1.8 0.1 0.4 0.6
Illnesses of father: High blood pressure 1.5 1.9 3.9 -1.3 -2.0 0.8 1.2
Alcohol drinker status: Never 0.3 0.3 0.7 0.3 0.4 -0.8 -0.6
Ever smoked 1.8 3.2 3.8 -1.4 -1.9 1.9 1.8
Basal metabolic rate 0.1 0.3 0.6 0.5 0.8 0.4 0.4
Leg fat percentage (left) 1.0 3.5 10.0 -0.5 -3.2 1.2 1.4
Arm fat-free mass (left) 0.0 0.2 0.3 0.5 0.5 0.5 0.5
Number of operations (self-reported) 1.7 2.5 6.2 -0.4 -2.5 1.3 1.4
Average weekly beer plus cider intake 0.1 0.2 0.3 -0.5 -0.6 -0.3 0.1
Irritability 1.9 3.2 12.2 0.5 -3.5 0.3 0.4
Risk taking 2.4 3.5 7.7 2.8 -1.3 -1.6 -1.4
Ever had prostate specific antigen (PSA) test 3.5 4.1 7.8 -2.8 -0.8 2.1 1.9
Fractured/broken bones in last 5 years 0.7 0.9 1.1 1.1 -0.4 -1.1 -1.0
Age started oral contraceptive pill 2.4 3.1 11.0 -0.9 3.3 -0.5 -0.4
Diastolic blood pressure, automated reading 0.4 1.4 2.4 0.6 -0.8 -1.5 -1.5
Ever depressed for a whole week 6.2 7.6 10.5 2.8 1.7 -3.0 -3.2
Unable to work because of sickness or disability 1.5 2.0 5.4 1.1 -2.3 0.8 0.8
Commuting to job workplace: Cycle 5.1 6.1 7.9 2.3 2.0 -2.7 -2.8
Myopia 0.6 0.9 2.0 -0.9 1.4 -0.5 -0.5
Vascular/heart problems diagnosed by doctor 0.3 0.7 1.8 1.3 0.4 0.7 0.7
Cholesterol lowering medication 0.4 0.6 1.0 -0.5 -0.2 1.0 1.0
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.8 -0.3 0.5 -0.9 -0.6
Pain experienced in last month 0.7 1.1 1.8 0.7 0.6 -1.3 -1.4
Supplements: Calcium 0.7 0.8 1.8 0.6 -0.0 -1.3 -1.1
Basal cell carcinoma (self-reported) 4.9 5.9 9.4 -2.6 -0.8 3.1 2.6
Heart attack/myocardial infarction (self-reported) 2.6 3.4 5.1 -1.0 -2.3 2.0 1.9
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 4.3 0.1 -2.1 0.1 0.1
Heart disease (siblings) 0.3 0.4 1.6 0.1 -1.3 0.0 0.2
Alcohol drinker status: Previous 0.6 0.6 0.8 0.9 0.7 -0.7 -0.8
Pack years of smoking 1.1 1.6 5.7 0.4 -2.4 0.5 0.5
Impedance of whole body 0.6 3.2 5.5 0.1 1.8 -2.1 -2.3
Leg fat mass (left) 0.6 2.2 5.8 -0.5 -2.4 1.1 1.2
Arm predicted mass (left) 0.1 0.3 0.4 0.4 0.4 0.6 0.7