Hub : Genes

RP11-552F3.9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.277 0.093 0.0024 0.157 NA 0.132 NA 0.159 7.8e-05 NA 0.00029 NA 0.00007
2 GTEx Cells EBV-transformed lymphocytes 0.500 0.126 0.0012 0.076 NA 0.107 NA 0.081 1.9e-03 NA 0.00024 NA 0.00130
3 GTEx Nerve Tibial 0.137 0.047 0.0014 0.051 NA 0.049 NA 0.066 1.7e-04 NA 0.00022 NA 0.00002

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.2 0.5 -0.7 -0.0 -0.0
Bipolar Disorder or Schizophrenia 1.5 3.6 5.8 -2.2 2.4 0.1
Depressed Affect (Nagel 2018) 0.9 1.9 4.6 0.3 1.1 2.1
Depression (Nagel 2018) 0.4 0.5 1.3 -0.5 1.1 0.0
Intelligence (Savage-Jansen 2018) 0.6 1.9 4.2 -1.1 -0.7 -2.0
Neuroticism (Nagel 2018) 0.4 1.0 2.3 0.8 0.2 1.5
Schizophrenia (2018) 2.6 5.3 10.8 -2.3 3.3 0.1
Schizophrenia vs Biploar Disorder 0.3 0.4 0.8 -0.5 0.9 0.3
Worry (Nagel 2018) 2.0 4.2 5.8 2.2 -1.4 2.4
Alzheimer’s Disease (in mother) 1.5 1.8 2.9 -1.7 1.5 -0.4
Alzheimer’s Disease (in father) 1.0 1.1 2.4 -1.6 0.8 -0.4
Alzheimer’s Disease (including proxy) 0.9 1.3 2.6 -1.6 1.1 -0.0
Crohns Disease (2017) 0.2 0.5 1.5 1.2 -0.2 0.1
Irritable Bowel Disease (IBD) 0.8 1.9 4.8 2.2 -0.8 0.4
Ulcerative Colitis (UC) 0.7 1.2 3.7 1.9 -0.0 0.1
Major Depression (MDD) 0.7 0.9 1.1 -0.8 1.1 0.9
Reaction Time 0.4 0.8 2.1 -0.0 0.7 -1.4
Verbal and Numeric Reasoning (VNR) 0.7 1.8 3.7 0.0 -1.3 -1.9
Breast Cancer 1.7 4.1 4.5 2.1 -2.0 1.9
Ovarian Cancer 0.7 0.9 1.3 0.8 -1.1 0.9
Prostate Cancer 0.8 1.1 2.5 0.6 -0.6 1.6
Age at First Birth 0.4 0.6 1.2 0.7 -1.1 -0.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.8 2.5 2.7 -1.6 1.5 -1.6
Coronary Artery Disease (CAD) 0.4 0.5 1.2 0.5 -1.1 0.3
Crohns Disease (2012) 0.2 0.3 0.4 0.6 -0.0 0.7
Mean Putamen Volume 0.7 0.8 1.7 1.3 -0.3 0.8
Fasting Glucose 1.7 2.0 2.4 1.2 -1.4 1.6
HbA1C 0.2 0.2 0.3 -0.1 -0.5 0.5
HDL Cholesterol 2.3 3.8 4.3 -2.1 1.7 -2.0
LDL Cholesterol 5.2 8.2 11.7 3.3 -3.4 1.4
Lupus 0.6 0.9 1.7 -1.1 1.3 -0.1
Neuroticism (2016) 1.0 1.4 4.3 0.1 -0.0 2.1
Primary Biliary Cirrhosis 0.6 0.9 2.0 0.7 -0.3 1.4
Rheumatoid Arthritis 2.8 3.8 7.9 -2.8 1.5 -1.1
Schizophrenia (2014) 1.6 3.6 5.9 -2.2 2.4 0.2
Triglycerides 2.6 4.2 5.1 2.3 -2.2 1.6
Type 2 Diabetes (T2D) (2012) 1.3 1.5 2.6 1.3 -1.6 -0.1
Ulcerative Colitis 0.7 1.0 1.8 1.3 -1.1 0.0
Blood Eosinophil Count 1.4 10.9 14.6 3.6 -2.3 3.8
Blood Platelet Count 1.5 17.6 25.2 4.7 -5.0 2.3
Blood Red Count 0.3 2.9 4.2 1.6 1.3 -2.1
Blood White Count 1.0 7.2 8.9 3.0 -2.1 2.9
Heel T-Score 0.2 1.7 3.8 -0.9 2.0 0.7
BMI 3.1 17.7 22.4 -4.7 4.2 -3.6
Height 0.2 3.0 5.7 -1.6 2.4 -1.0
Waist Hip Ratio (WHR) 1.5 6.6 16.2 1.5 -1.2 4.0
Systolic Blood Pressure 6.3 31.7 35.8 5.5 -5.3 6.0
Smoking Status 1.4 3.5 7.0 -2.7 1.2 1.4
Allergy or Eczema 0.4 0.9 1.3 -1.1 0.7 -1.1
Cardiovascular Disease 5.7 18.8 26.9 4.0 -3.7 5.2
Hypothyroidism (self reported) 7.3 16.7 28.1 -5.3 4.7 0.0
Respiratory disease 6.9 15.4 21.1 -4.0 4.6 -3.0
Type 2 Diabetes (T2D) (2018) 1.3 2.4 5.0 -1.2 2.2 0.8
Lung FEV1/FVC ratio 0.0 0.1 0.3 -0.5 0.2 0.3
Lung FVC 0.8 3.9 5.8 -2.2 0.9 -2.4
Neuroticism 0.7 1.7 4.2 0.8 0.4 2.1
Chronotype (morning person) 2.6 6.1 9.5 2.5 -3.1 1.7
Hair Pigment 0.5 15.4 23.2 4.0 -4.8 2.5
Tanning 0.1 1.5 4.1 -0.2 0.7 -2.0
Hand grip strength (left) 0.9 2.3 3.8 0.9 -1.5 2.0
Number of treatments/medications taken 1.0 1.8 2.9 -1.7 1.4 0.8
Average weekly spirits intake 0.6 0.7 2.0 -0.1 -1.4 0.2
Sensitivity / hurt feelings 0.1 0.2 0.4 -0.2 -0.1 0.6
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.0 0.3 -0.1 1.0
Hearing difficulty/problems: Yes 0.3 0.4 1.2 -0.2 -1.1 0.1
Relative age of first facial hair 0.7 1.5 2.0 -1.3 0.8 1.4
Other serious medical condition/disability diagnosed by doctor 1.9 2.4 4.7 -2.2 1.5 -0.7
Ever used hormone-replacement therapy (HRT) 1.0 1.3 3.1 0.2 -0.9 1.8
Ever had hysterectomy (womb removed) 0.7 0.7 1.0 -0.7 0.9 -1.0
Systolic blood pressure, automated reading 1.8 5.2 8.2 2.1 -1.7 2.9
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 2.8 -1.7 1.4 0.2
Angina 0.6 0.7 1.9 -1.4 0.4 0.3
Medication for hormone replacement therapy 0.8 0.9 1.4 -1.1 1.2 0.2
Vitamin and mineral supplements 0.1 0.1 0.3 0.5 0.1 -0.3
Supplements: Zinc 0.1 0.1 0.2 -0.5 0.4 -0.0
Medication: Co-codamol 3.5 4.1 7.3 -2.1 2.7 0.7
Medication: Metformin 0.9 1.2 3.0 -0.7 1.7 0.3
Diabetes (father) 0.3 0.3 0.4 0.6 -0.5 0.6
Diabetes (mother) 0.1 0.1 0.1 -0.3 0.3 0.3
Severe depression (siblings) 2.2 2.4 4.3 -2.1 1.5 -0.8
Pack years adult smoking proportion 2.9 4.5 6.7 -2.6 2.5 -0.6
Impedance of leg (right) 1.0 5.1 7.3 2.0 -2.0 2.7
Leg fat-free mass (left) 1.6 8.5 9.1 -3.0 2.8 -2.9
Trunk fat percentage 4.4 17.5 20.7 -4.6 4.1 -3.9
Hand grip strength (right) 0.6 1.6 3.4 0.4 -1.1 1.9
Townsend deprivation index at recruitment 0.3 0.5 0.7 0.9 -0.7 0.4
Current tobacco smoking 2.0 3.3 4.2 -2.0 2.1 1.3
Average weekly fortified wine intake 0.7 0.8 2.3 -0.3 -0.2 -1.5
Maternal smoking around birth 1.9 2.8 4.5 -1.7 2.1 -1.1
Fed-up feelings 1.0 1.8 4.8 0.7 0.2 2.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.6 0.1 0.5 0.8
Relative age voice broke 0.3 0.4 0.8 -0.9 0.7 0.0
Taking other prescription medications 2.1 3.2 8.0 -2.8 1.2 -0.6
Age when periods started (menarche) 0.1 0.2 0.5 -0.1 -0.7 -0.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.5 -0.7 0.2 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.6 4.4 -1.8 2.1 0.1
Tinnitus: Yes, but not now, but have in the past 2.7 2.9 5.7 -2.4 1.6 -0.5
Qualifications: CSEs or equivalent 2.6 3.5 4.5 1.9 -1.5 2.1
Serious illness, injury or assault to yourself 0.5 0.6 1.0 -0.9 0.4 -1.0
High blood pressure 4.8 13.3 17.8 3.4 -3.2 4.2
Hayfever, allergic rhinitis or eczema 1.6 3.5 5.1 -2.3 1.2 -2.0
Multivitamins +/- minerals 0.1 0.1 0.2 -0.4 -0.3 0.3
Stomach or abdominal pain in last month 1.1 1.4 3.1 -1.0 -0.3 1.8
Supplements: Glucosamine 0.3 0.4 1.0 -0.1 -0.3 1.0
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.0 -1.0 0.3 0.7
Medication: Atenolol 4.1 5.1 7.7 2.3 -1.6 2.8
Medication: Levothyroxine sodium 5.7 9.6 15.0 -3.9 3.5 1.3
Sitting height 0.1 0.6 1.2 1.1 -0.8 0.1
Chronic bronchitis/emphysema (father) 0.7 0.8 2.0 -0.2 1.4 -0.7
High blood pressure (mother) 3.4 4.8 6.0 2.5 -2.4 1.5
Body mass index (BMI) 3.0 12.7 16.7 -4.1 3.4 -3.1
Impedance of leg (left) 1.0 4.8 7.6 1.9 -1.8 2.8
Leg predicted mass (left) 1.6 8.6 9.5 -3.1 2.8 -2.9
Trunk fat mass 4.0 17.3 21.6 -4.7 4.2 -3.6
Waist circumference 2.9 10.6 15.6 -3.9 3.6 -1.7
Number of incorrect matches in round 1.8 3.0 4.2 2.0 -0.8 2.1
Past tobacco smoking 0.4 0.7 0.9 0.9 0.5 -0.9
Alcohol usually taken with meals 0.4 0.6 1.6 1.2 0.4 -0.2
Nervous feelings 2.4 4.4 6.1 2.2 -1.6 2.5
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.6 0.6 0.5 0.8
Hearing difficulty/problems with background noise 1.0 1.6 2.6 -1.1 1.6 -0.9
Hair/balding pattern: Pattern 2 0.3 0.3 0.5 0.1 0.7 0.7
Had menopause 0.3 0.3 0.9 -1.0 0.2 0.2
Had other major operations 0.1 0.1 0.2 0.4 0.1 -0.1
Forced vital capacity (FVC) 0.5 2.0 3.3 -1.6 0.3 -1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 2.3 -1.4 1.5 0.7
Ever unenthusiastic/disinterested for a whole week 2.0 2.4 3.4 1.8 -1.8 0.8
Qualifications: None of the above 0.1 0.2 0.4 0.5 0.1 -0.6
Financial difficulties in last 2 years 1.2 1.6 1.9 -1.3 1.2 -1.4
Mouth/teeth dental problems 0.4 0.6 1.5 0.5 -1.2 0.3
Heart attack 1.3 1.7 3.1 0.9 -1.1 1.8
Allergy 4.6 10.5 15.4 3.9 -3.1 2.5
Pain all over the body in last month 3.5 3.7 7.2 -2.7 2.0 -0.1
Diabetes (self-reported) 2.4 3.7 7.5 -1.9 2.7 -0.3
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.9 -0.9 0.4 0.7
Medication: Ramipril 0.2 0.3 0.4 0.6 -0.7 -0.2
Medication: Simvastatin 3.1 4.5 6.6 2.5 -0.9 2.6
Fluid intelligence score 0.5 1.1 2.8 -0.3 -0.7 -1.7
Illnesses of siblings 2.0 2.8 3.8 -1.8 1.9 -1.1
Neuroticism score 1.3 2.6 5.3 1.5 -0.6 2.3
Weight 2.5 12.2 16.2 -4.0 3.6 -2.8
Impedance of arm (right) 0.1 0.5 1.3 0.1 0.3 -1.1
Arm fat percentage (right) 5.3 21.0 24.0 -4.9 4.4 -4.4
Trunk fat-free mass 0.2 1.0 1.7 -1.3 1.1 -0.2
Hip circumference 4.2 18.0 23.7 -4.9 4.2 -3.6
Time employed in main current job 1.3 1.5 3.7 -1.9 0.6 0.5
Alcohol intake versus 10 years previously 1.9 2.8 7.1 1.0 -0.6 2.7
Father’s age at death 0.8 1.0 1.7 -0.4 1.1 -1.3
Worrier / anxious feelings 1.8 3.5 6.7 1.7 -0.9 2.6
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 1.9 -1.0 1.4 -0.3
Falls in the last year 0.5 0.6 1.3 -1.2 0.0 -0.8
Hair/balding pattern: Pattern 3 0.7 1.0 2.9 -0.3 -0.2 -1.7
Number of live births 1.5 2.2 3.5 -1.5 0.9 -1.9
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 3.4 -1.7 0.5 -1.8
Pulse rate 0.2 0.4 0.9 -0.1 -0.9 0.5
Happiness 1.0 1.2 3.0 -0.1 -0.8 1.7
Noisy workplace 0.8 1.0 1.9 -0.9 -0.6 1.4
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.6 -0.0 -0.4 -1.3
Serious illness, injury or assault of a close relative in last 2 years 2.4 2.8 4.8 -1.1 1.5 -2.2
Mouth/teeth dental problems: Dentures 0.0 0.1 0.1 -0.1 0.3 -0.2
Asthma 5.5 10.8 11.8 -3.1 3.4 -3.3
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.0 -1.0 1.4 -0.1
Medication: Cholesterol lowering 2.2 3.4 5.9 1.8 -1.1 2.4
Depression (self-reported) 0.1 0.2 0.4 -0.7 -0.1 -0.3
Medication: Lansoprazole 0.8 0.9 2.2 -1.5 0.6 -0.2
Prospective memory result 3.1 3.8 5.0 2.0 -1.6 2.2
Lung cancer (father) 0.5 0.6 1.3 0.3 0.6 1.1
Illnesses of mother 0.8 1.0 1.7 -1.3 0.8 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.2 4.8 -1.9 1.2 -2.2
Pulse wave Arterial Stiffness index 0.2 0.2 0.7 -0.1 -0.0 0.8
Impedance of arm (left) 0.1 0.5 1.4 0.1 0.3 -1.2
Arm fat mass (right) 4.0 16.4 18.8 -4.3 3.8 -4.0
Trunk predicted mass 0.2 0.9 1.5 -1.2 1.0 -0.2
Standing height 0.0 0.2 0.4 0.1 0.4 0.6
Length of working week for main job 0.6 0.6 1.3 -0.7 1.1 -0.2
Exposure to tobacco smoke at home 1.0 1.2 3.4 -0.4 -0.1 1.8
Breastfed as a baby 0.3 0.4 0.7 0.9 -0.4 0.5
Tense / ‘highly strung’ 0.3 0.5 1.0 0.5 -0.3 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 1.8 -1.0 1.4 1.0
Hair/balding pattern: Pattern 4 2.0 4.8 7.1 2.4 -1.3 2.7
Birth weight of first child 1.4 2.6 4.0 2.0 -1.4 1.3
Peak expiratory flow (PEF) 0.7 1.7 3.0 -1.7 1.1 -1.1
Pulse wave reflection index 0.0 0.0 0.0 -0.0 0.2 0.1
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.0 -0.4 -0.3 -1.0
Loud music exposure frequency 1.4 1.5 2.5 0.8 -1.2 1.6
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 1.9 0.4 -1.4 -1.0
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 4.9 -1.2 2.2 -0.5
Blood clot in the leg (DVT) 5.4 7.0 11.2 -3.4 3.0 -0.7
Medication: Paracetamol 0.4 0.7 2.0 -0.4 -0.2 1.4
Headache pain in last month 0.3 0.5 0.8 0.7 -0.9 -0.6
Medication for cholesterol, blood pressure or diabetes 3.1 5.2 12.3 -1.6 0.7 -3.5
Glaucoma (self-reported) 1.1 1.3 1.9 1.4 -1.3 0.7
Gout (self-reported) 0.0 0.0 0.0 0.0 -0.1 0.2
Hypothyroidism/myxoedema (self-reported) 5.5 10.7 19.8 -4.4 3.5 0.6
Medication: Amlodipine 1.3 1.8 4.3 1.0 0.4 2.1
Medication: Ventolin 100micrograms inhaler 1.5 1.9 2.3 -1.4 1.1 -1.5
Birth weight 0.2 0.3 0.5 -0.7 0.5 0.5
Chronic bronchitis/emphysema (mother) 0.4 0.4 0.8 -0.9 0.4 0.5
High blood pressure (siblings) 2.4 3.4 5.3 2.3 -1.9 1.2
Forced vital capacity (FVC), Best measure 0.7 2.4 3.9 -1.5 1.0 -2.0
Body fat percentage 4.5 17.9 23.1 -4.8 4.2 -3.6
Leg fat percentage (right) 3.7 13.3 20.9 -4.6 3.6 -2.4
Arm fat-free mass (right) 0.5 2.6 4.3 -2.1 1.7 -0.8
Exposure to tobacco smoke outside home 0.5 0.6 1.6 -1.3 0.5 -0.2
Comparative body size at age 10 1.0 2.7 7.4 -0.7 2.7 0.4
Number of full brothers 0.9 1.1 2.7 -0.2 -0.8 -1.6
Worry too long after embarrassment 0.4 0.6 1.8 -0.1 0.2 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.5 -1.2 0.8 0.2
Wheeze or whistling in the chest in last year 4.0 7.2 11.4 -3.1 3.4 -0.5
Number of children fathered 2.0 2.3 3.5 -1.9 1.3 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 1.7 1.2 -0.6 1.3
Age at first live birth 0.3 0.5 0.7 0.8 -0.7 0.6
Pulse wave peak to peak time 0.2 0.3 0.6 0.4 -0.1 -0.8
Health satisfaction 3.0 3.9 7.5 -2.7 1.5 1.5
Shortness of breath walking on level ground 1.4 1.7 2.6 -1.6 1.6 -0.2
Qualifications: College or University degree 0.1 0.3 0.6 -0.5 0.8 0.4
Eye problems/disorders: None of the above 0.8 0.9 1.6 0.7 -1.3 -0.8
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.2 -0.5 0.7 1.1
Emphysema/chronic bronchitis 0.8 0.9 1.5 -1.1 1.2 -0.1
Medication for pain relief, constipation, heartburn 0.1 0.2 0.4 0.5 -0.3 -0.6
Neck or shoulder pain in last month 0.5 0.7 1.1 -0.3 1.1 1.0
Medication: Blood pressure 2.5 4.4 10.4 1.5 -0.8 3.2
Angina (self-reported) 0.5 0.7 1.8 -1.3 0.5 0.1
Migraine (self-reported) 1.1 1.3 3.7 0.5 -1.9 0.1
Medication: Ibuprofen 2.0 2.4 3.8 -1.8 2.0 -0.4
Medication: Allopurinol 0.7 0.9 1.5 1.2 -1.2 0.0
Medication: Omeprazole 0.7 0.8 1.8 -1.3 0.2 -0.7
Medication: Seretide 50 evohaler 3.7 4.2 5.3 -2.3 2.3 -1.5
Mean time to correctly identify matches 0.4 0.8 1.7 0.8 -0.1 -1.3
Heart disease (mother) 0.4 0.5 1.0 1.0 -0.4 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 1.6 -1.3 1.0 -0.9
Whole body fat mass 3.5 14.7 18.7 -4.3 3.9 -3.3
Leg fat mass (right) 4.1 15.8 22.3 -4.7 4.0 -3.0
Arm predicted mass (right) 0.6 2.9 4.9 -2.2 1.7 -1.0
Pulse rate, automated reading 1.0 3.3 5.0 0.2 -2.2 2.2
Alcohol intake frequency. 0.5 1.2 2.5 1.6 -0.9 0.4
Comparative height size at age 10 0.0 0.3 0.7 -0.4 0.8 -0.0
Number of full sisters 0.8 1.0 2.1 -0.5 0.8 -1.4
Suffer from ‘nerves’ 4.3 6.8 8.4 2.3 -2.5 2.9
Overall health rating 1.1 2.4 6.9 -0.5 0.4 2.6
Chest pain or discomfort 0.1 0.1 0.4 -0.6 0.0 0.2
Had major operations 0.8 1.0 2.0 0.9 -1.4 -0.2
Age at last live birth 0.4 0.6 1.2 0.7 -1.1 0.4
Family relationship satisfaction 3.0 3.7 9.1 -0.1 -1.4 3.0
Leg pain on walking 1.8 2.2 6.2 -0.5 -0.5 2.5
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.6 0.4 -0.7 -0.0
Commuting to job workplace: Car/motor vehicle 5.5 6.2 11.2 -3.3 2.7 -0.5
Illness, injury, bereavement, stress in last 2 years 0.5 0.7 1.1 0.6 -0.8 1.0
Medication: Aspirin 0.4 0.5 1.3 0.4 -0.2 1.2
Supplements: Vitamin C 0.2 0.2 0.4 0.4 -0.2 -0.6
Knee pain experienced in last month 0.6 0.9 2.4 0.5 0.2 1.5
Hypertension (Self-reported) 4.6 12.7 19.1 3.1 -3.0 4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 1.4 -1.0 -0.8 -1.2
Illnesses of father: Heart disease 0.2 0.3 0.4 0.1 -0.5 0.7
Illnesses of siblings: Diabetes 0.1 0.1 0.4 -0.1 -0.0 -0.7
Smoking status: Previous 0.9 1.4 2.0 -0.4 -1.4 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.2 -0.1 0.3 -0.5
Whole body fat-free mass 0.6 3.2 4.5 -2.1 1.9 -1.3
Leg fat-free mass (right) 1.5 7.8 8.4 -2.9 2.8 -2.7
Arm fat percentage (left) 5.2 20.6 24.0 -4.9 4.3 -4.3
Average weekly red wine intake 1.5 2.2 4.0 -0.0 1.6 -2.0
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 -0.2 0.2 0.1
Mood swings 0.6 1.2 2.3 0.8 0.7 1.5
Loneliness, isolation 2.1 2.9 6.3 1.4 -0.6 2.5
Long-standing illness, disability or infirmity 1.9 3.0 6.4 -2.5 1.3 -0.8
Ever had bowel cancer screening 2.0 2.4 7.0 0.4 -0.2 2.6
Diabetes diagnosed by doctor 1.1 1.8 3.8 -1.2 1.9 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.8 -1.3 0.5 -0.3
Friendships satisfaction 0.9 1.1 2.2 -0.6 -0.8 1.5
Qualifications: nursing, teaching 1.2 1.8 2.9 -1.7 0.8 -1.4
Commuting to job workplace: Walk 2.9 3.1 4.2 2.0 -1.7 1.5
Eye problems/disorders: Cataract 0.5 0.6 1.5 -0.3 1.2 0.5
Mouth/teeth dental problems: Mouth ulcers 0.3 0.6 0.9 0.9 -1.0 0.1
Medication for cholesterol 1.0 1.5 3.2 -1.1 0.4 -1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.3 2.7 4.3 -2.1 1.7 -0.9
Back pain experienced in last month 0.3 0.4 1.1 0.2 -0.5 1.0
Mineral and other dietary supplements 1.1 1.5 3.3 -0.8 0.8 -1.8
Breast cancer (self-reported) 2.3 2.7 3.7 1.9 -1.9 -0.9
Asthma (self-reported) 5.9 11.8 13.0 -3.1 3.6 -3.6
Osteoporosis (self-reported) 2.1 2.5 6.9 0.0 -0.9 -2.6
Osteoarthritis (self-reported) 1.0 1.3 3.1 -0.6 0.7 1.8
Medication: Aspirin 0.1 0.2 0.4 0.4 -0.1 0.7
Medication: Gliclazide 0.4 0.5 1.3 0.3 -0.3 1.1
Illnesses of father: None of the above (group 1) 0.2 0.3 0.5 0.7 -0.6 0.0
Smoking status: Current 1.8 2.9 3.9 -1.8 2.0 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 3.0 6.8 -1.3 0.8 -2.6
Whole body water mass 0.6 3.3 4.4 -2.1 1.9 -1.3
Leg predicted mass (right) 1.5 7.8 8.4 -2.9 2.8 -2.7
Arm fat mass (left) 4.0 16.6 18.7 -4.3 3.8 -4.1
Number of self-reported non-cancer illnesses 0.3 0.5 1.5 -0.3 -0.1 1.2
Average weekly champagne plus white wine intake 0.5 0.7 1.7 0.0 0.5 1.3
Miserableness 0.7 1.2 3.6 -0.1 0.2 1.9
Guilty feelings 0.0 0.1 0.1 -0.1 -0.3 0.3
Wears glasses or contact lenses 0.7 0.8 2.0 -0.7 0.2 1.4
Ever taken oral contraceptive pill 0.5 0.5 1.1 -0.6 -0.4 1.0
Hearing aid user 0.1 0.1 0.2 -0.3 0.0 -0.5
Mother’s age at death 0.0 0.0 0.1 -0.2 -0.1 0.3
Financial situation satisfaction 0.5 0.6 1.1 -1.1 -0.1 0.8
Tinnitus: Yes, now most or all of the time 0.6 0.6 0.8 -0.9 0.7 -0.8
Commuting to job workplace: Public transport 0.2 0.2 0.4 0.2 -0.4 0.7
Eye problems/disorders: Glaucoma 1.5 1.8 2.7 1.2 -1.7 1.1
Medication: Blood pressure 0.6 1.2 1.8 1.0 -1.4 0.9
Pain type(s) experienced in last month: Hip pain 0.6 0.8 2.2 -0.1 0.3 1.5
Supplements: Fish oil (including cod liver oil) 1.5 2.0 4.4 0.8 -1.0 2.1
High cholesterol (Self-reported) 11.5 20.4 28.7 5.4 -3.7 4.3
Medication: Bendroflumethiazide 1.5 2.3 3.3 1.8 -1.8 0.8
Medication: Paracetamol 0.5 0.8 2.0 -0.6 -0.1 1.4
Medication: Lisinopril 1.8 2.4 5.0 1.0 -1.0 2.2
Medication: Atorvastatin 2.0 2.5 4.7 1.3 -1.1 2.2
Illnesses of father: High blood pressure 0.1 0.1 0.3 -0.0 -0.5 0.2
Alcohol drinker status: Never 0.8 0.9 1.9 -0.8 0.4 -1.4
Ever smoked 0.1 0.2 0.6 -0.8 -0.2 0.1
Basal metabolic rate 0.9 5.2 6.9 -2.6 2.3 -1.8
Leg fat percentage (left) 4.1 14.8 23.1 -4.8 3.9 -2.4
Arm fat-free mass (left) 0.5 2.4 3.4 -1.8 1.6 -1.2
Number of operations (self-reported) 1.3 1.9 2.8 -1.4 1.0 -1.7
Average weekly beer plus cider intake 0.0 0.0 0.1 0.0 -0.3 -0.0
Irritability 0.6 1.0 2.3 -0.8 1.5 0.0
Risk taking 1.7 2.5 5.1 -1.5 2.3 -0.3
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.0 -0.0 0.1 0.0
Fractured/broken bones in last 5 years 0.2 0.3 0.4 -0.6 0.6 -0.1
Age started oral contraceptive pill 0.3 0.4 0.9 -0.3 0.9 -0.3
Diastolic blood pressure, automated reading 2.3 7.2 14.6 1.7 -2.0 3.8
Ever depressed for a whole week 0.7 0.9 1.4 0.9 -0.7 1.2
Unable to work because of sickness or disability 2.6 3.4 6.1 -2.5 2.0 0.4
Commuting to job workplace: Cycle 0.4 0.5 1.0 0.5 -0.5 -1.0
Myopia 0.6 0.8 2.0 1.4 -0.6 0.3
Vascular/heart problems diagnosed by doctor 4.0 10.8 15.3 -3.0 2.9 -3.9
Cholesterol lowering medication 2.1 3.2 4.8 2.1 -0.4 2.2
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.9 -1.0 -0.2 -0.4
Pain experienced in last month 0.6 1.0 2.5 -0.7 0.3 -1.6
Supplements: Calcium 0.2 0.2 0.4 -0.4 0.2 -0.6
Basal cell carcinoma (self-reported) 0.5 0.6 1.2 -0.5 1.1 -0.7
Heart attack/myocardial infarction (self-reported) 2.0 2.5 4.3 1.2 -1.4 2.1
Deep venous thrombosis (DVT) (self-reported) 5.5 7.1 11.6 -3.4 3.0 -0.9
Heart disease (siblings) 2.4 3.0 4.0 1.9 -2.0 1.1
Alcohol drinker status: Previous 0.4 0.5 1.1 1.0 -0.3 0.5
Pack years of smoking 2.8 4.1 6.5 -2.5 2.4 -0.4
Impedance of whole body 0.1 0.6 0.9 1.0 -0.7 0.6
Leg fat mass (left) 4.2 16.6 23.1 -4.8 4.1 -3.1
Arm predicted mass (left) 0.5 2.6 4.0 -2.0 1.6 -1.2