Hub : Genes

RP11-572O17.1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue (Male)	0.0548	0.1344	3.6e-01	-0.012	NA	-0.011	NA	-0.005	0.750	NA	0.7000	NA	0.44
2	GTEx	Breast Mammary Tissue (Female)	0.0333	0.0485	2.7e-01	-0.010	NA	-0.006	NA	0.007	0.850	NA	0.5400	NA	0.19
3	GTEx	Ovary	0.3490	0.0920	7.9e-05	0.035	NA	0.128	NA	0.053	0.049	NA	0.0005	NA	0.02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.0	0.0	0.1	0.0	-0.2	0.0
Bipolar Disorder or Schizophrenia	0.1	0.1	0.4	0.0	-0.6	0.0
Depressed Affect (Nagel 2018)	0.5	1.1	3.2	0.3	-0.3	1.8
Depression (Nagel 2018)	0.1	0.1	0.4	-0.1	0.0	0.6
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.0	0.9	0.8	-1.0
Neuroticism (Nagel 2018)	0.2	0.4	0.8	0.6	0.3	0.9
Schizophrenia (2018)	0.5	1.1	2.6	-1.6	-0.6	-0.5
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.0	0.5	0.0
Worry (Nagel 2018)	0.3	0.6	1.1	0.9	1.1	0.1
Alzheimer’s Disease (in mother)	1.1	1.2	3.3	-0.1	1.8	-0.6
Alzheimer’s Disease (in father)	0.6	0.6	1.3	-0.6	-1.1	0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.9	-0.4	1.4	-0.2
Crohns Disease (2017)	0.6	1.3	3.6	-0.5	-0.3	-1.9
Irritable Bowel Disease (IBD)	0.7	1.6	4.6	0.2	0.3	-2.1
Ulcerative Colitis (UC)	1.0	1.8	2.2	1.3	1.5	-1.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.2	0.3	0.7	0.8	-0.4	-0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.4	1.2	0.8	-0.5
Breast Cancer	0.6	1.5	2.7	0.4	1.6	1.4
Ovarian Cancer	0.1	0.1	0.2	0.0	-0.4	-0.4
Prostate Cancer	1.0	1.4	2.9	0.3	-1.7	1.1
Age at First Birth	0.1	0.2	0.3	0.5	0.5	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	2.0	0.9	-0.9	1.4
Coronary Artery Disease (CAD)	0.2	0.2	0.6	0.0	-0.8	0.0
Crohns Disease (2012)	0.8	1.2	2.6	0.0	-1.0	-1.6
Mean Putamen Volume	0.2	0.3	0.5	-0.1	-0.6	0.7
Fasting Glucose	0.9	1.0	1.4	-1.0	-1.2	-0.9
HbA1C	1.8	2.0	4.0	-2.0	0.9	1.0
HDL Cholesterol	0.1	0.2	0.3	0.0	-0.5	-0.6
LDL Cholesterol	1.3	2.0	5.8	0.0	0.3	2.4
Lupus	1.2	1.9	4.7	-0.4	-2.2	-0.9
Neuroticism (2016)	0.4	0.5	1.6	0.0	0.2	1.3
Primary Biliary Cirrhosis	0.7	1.0	2.1	0.4	1.5	-0.9
Rheumatoid Arthritis	1.6	2.2	4.1	-0.5	-1.5	-2.0
Schizophrenia (2014)	0.3	0.7	1.3	-1.1	0.5	-0.8
Triglycerides	0.4	0.7	1.4	0.0	-1.2	0.8
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	-0.1
Ulcerative Colitis	1.1	1.6	2.0	1.0	1.3	-1.4
Blood Eosinophil Count	0.3	2.4	6.4	0.6	2.5	-0.7
Blood Platelet Count	0.3	3.9	9.2	-3.0	-1.6	0.3
Blood Red Count	0.1	1.2	2.0	0.2	1.2	1.4
Blood White Count	0.2	1.5	4.3	-0.5	0.2	-2.1
Heel T-Score	1.1	8.9	26.2	0.2	-0.6	5.1
BMI	0.1	0.3	0.5	-0.7	-0.4	0.6
Height	1.0	19.7	29.3	-2.7	-5.4	4.8
Waist Hip Ratio (WHR)	1.7	7.8	11.3	-0.9	3.3	3.4
Systolic Blood Pressure	0.1	0.7	1.4	0.8	-1.2	0.3
Smoking Status	0.6	1.4	3.7	0.6	-0.1	1.9
Allergy or Eczema	0.4	1.1	2.3	1.5	0.9	0.2
Cardiovascular Disease	0.1	0.3	0.5	-0.6	-0.7	0.4
Hypothyroidism (self reported)	0.6	1.4	3.2	0.5	-1.8	0.8
Respiratory disease	0.3	0.7	1.8	0.4	1.4	-0.5
Type 2 Diabetes (T2D) (2018)	1.6	3.0	6.8	1.5	0.1	-2.6
Lung FEV1/FVC ratio	0.1	0.6	1.6	0.0	0.5	1.2
Lung FVC	1.4	7.2	20.6	0.8	4.5	0.4
Neuroticism	0.1	0.3	0.7	-0.2	0.4	0.9
Chronotype (morning person)	1.3	3.1	9.1	-0.0	0.5	-3.0
Hair Pigment	0.1	2.1	5.1	-0.9	-2.3	-0.7
Tanning	0.2	3.0	5.9	1.4	-1.1	-2.4
Hand grip strength (left)	2.7	7.2	13.5	-0.7	2.7	3.7
Number of treatments/medications taken	0.6	1.0	2.7	-0.2	-1.6	0.6
Average weekly spirits intake	1.9	2.4	6.0	2.5	0.8	-0.6
Sensitivity / hurt feelings	0.1	0.2	0.3	0.4	-0.5	0.1
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.2	-0.8	1.1	1.0
Hearing difficulty/problems: Yes	1.2	1.9	3.9	-2.0	0.8	-1.1
Relative age of first facial hair	0.0	0.0	0.0	-0.1	0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.4	-0.9	1.2	0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.4	0.6	-0.5	0.6
Ever had hysterectomy (womb removed)	1.0	1.1	2.9	-1.7	0.5	0.5
Systolic blood pressure, automated reading	0.7	2.1	5.2	-0.7	-2.3	0.8
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.7	1.3	1.0	0.7
Angina	2.7	3.6	7.9	-2.8	0.3	1.6
Medication for hormone replacement therapy	1.2	1.3	2.8	-0.2	1.7	1.1
Vitamin and mineral supplements	0.5	0.6	1.9	0.1	-1.4	0.1
Supplements: Zinc	0.4	0.5	0.9	-0.7	0.9	-0.2
Medication: Co-codamol	1.3	1.5	2.9	1.2	-1.7	0.1
Medication: Metformin	1.1	1.5	3.6	0.4	0.8	-1.9
Diabetes (father)	1.9	2.3	4.8	1.2	0.9	-2.2
Diabetes (mother)	0.7	1.0	1.2	0.9	1.1	-0.9
Severe depression (siblings)	1.2	1.4	4.0	0.3	-2.0	-0.0
Pack years adult smoking proportion	0.7	1.1	2.5	-0.6	-1.6	-0.5
Impedance of leg (right)	0.2	0.8	1.4	-0.8	-0.5	-1.2
Leg fat-free mass (left)	0.4	1.9	3.7	0.1	-1.4	1.9
Trunk fat percentage	0.2	1.0	1.6	-1.0	-1.3	0.6
Hand grip strength (right)	2.9	7.9	17.6	-1.4	2.0	4.2
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.0	0.5	-0.4
Current tobacco smoking	0.4	0.6	1.1	0.4	-1.0	0.7
Average weekly fortified wine intake	0.6	0.7	1.8	-0.1	0.5	-1.3
Maternal smoking around birth	0.4	0.6	1.1	-0.7	0.4	1.1
Fed-up feelings	0.9	1.6	2.7	1.6	-0.5	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.0	-0.6	0.4
Relative age voice broke	0.3	0.4	1.2	0.0	-0.0	1.1
Taking other prescription medications	0.6	0.9	1.1	-1.1	-0.9	0.7
Age when periods started (menarche)	0.0	0.1	0.3	-0.1	0.5	0.2
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	2.9	-0.4	-1.7	1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	6.3	-1.2	0.8	2.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.7	-0.8	-0.3	-0.1
Qualifications: CSEs or equivalent	0.3	0.4	0.8	0.5	-0.3	0.9
Serious illness, injury or assault to yourself	0.1	0.1	0.1	-0.3	-0.4	0.2
High blood pressure	0.3	0.8	1.4	0.5	-1.2	-0.9
Hayfever, allergic rhinitis or eczema	0.7	1.5	4.0	2.0	0.8	0.2
Multivitamins +/- minerals	0.0	0.0	0.1	-0.3	0.2	-0.1
Stomach or abdominal pain in last month	1.1	1.4	3.4	-1.8	0.1	-0.9
Supplements: Glucosamine	0.4	0.5	0.7	0.8	0.5	0.8
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	1.5	-1.2	-1.2	0.3
Medication: Atenolol	1.5	1.8	3.8	-1.9	-0.8	1.1
Medication: Levothyroxine sodium	0.3	0.5	0.9	0.6	-0.9	0.4
Sitting height	0.4	3.2	5.2	-0.9	-2.3	1.9
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	0.2	-0.3	0.8
High blood pressure (mother)	1.6	2.2	4.4	2.1	-1.4	-0.6
Body mass index (BMI)	0.2	0.8	1.8	0.1	-1.3	0.7
Impedance of leg (left)	0.2	0.7	2.2	-1.5	0.1	-0.2
Leg predicted mass (left)	0.4	1.9	3.7	0.3	-1.4	1.9
Trunk fat mass	0.4	1.7	2.9	-1.0	-1.7	1.1
Waist circumference	0.3	1.2	2.3	-0.1	-1.2	1.5
Number of incorrect matches in round	1.9	3.1	5.9	-0.4	2.4	1.8
Past tobacco smoking	0.8	1.5	3.0	-0.5	-1.1	-1.7
Alcohol usually taken with meals	0.6	0.9	2.0	-0.3	-0.7	1.4
Nervous feelings	0.5	0.9	1.7	1.0	0.3	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.1	-1.1	-0.0	1.8
Hearing difficulty/problems with background noise	0.6	0.9	1.4	-1.2	1.1	-0.5
Hair/balding pattern: Pattern 2	0.6	0.8	1.2	-1.1	0.9	0.5
Had menopause	0.5	0.6	0.9	-0.7	-0.9	-0.7
Had other major operations	0.3	0.4	0.6	-0.4	-0.8	0.7
Forced vital capacity (FVC)	0.4	1.4	3.3	0.3	1.8	0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.8	9.6	-1.3	0.1	3.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.9	-0.4	-0.5	0.9
Qualifications: None of the above	3.3	7.1	19.9	0.3	-4.5	-1.1
Financial difficulties in last 2 years	1.1	1.4	3.5	-0.9	-1.9	0.2
Mouth/teeth dental problems	0.6	0.9	2.1	0.8	1.5	-0.2
Heart attack	0.8	1.1	2.0	-1.4	-1.1	-0.3
Allergy	0.9	2.0	3.5	-1.9	-1.3	-0.9
Pain all over the body in last month	0.7	0.7	1.0	1.0	0.8	-0.8
Diabetes (self-reported)	1.1	1.7	3.3	0.9	1.0	-1.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	-0.1	-1.2	0.3
Medication: Ramipril	0.1	0.1	0.2	0.3	0.2	0.5
Medication: Simvastatin	0.7	1.1	3.0	-1.7	0.5	-0.0
Fluid intelligence score	0.4	0.9	1.8	1.4	1.0	0.2
Illnesses of siblings	0.6	0.9	2.0	0.3	1.4	0.8
Neuroticism score	0.0	0.0	0.1	-0.3	-0.1	-0.1
Weight	0.5	2.4	4.2	0.1	-2.0	1.8
Impedance of arm (right)	0.3	1.6	2.8	-0.9	1.0	-1.7
Arm fat percentage (right)	0.1	0.5	1.0	-0.6	-1.0	0.1
Trunk fat-free mass	0.6	3.2	5.8	0.3	-1.9	2.4
Hip circumference	0.6	2.8	8.1	0.2	-2.8	0.4
Time employed in main current job	0.3	0.3	0.9	-0.0	-0.9	0.2
Alcohol intake versus 10 years previously	0.6	0.9	2.2	1.5	-0.1	-0.6
Father’s age at death	1.2	1.6	2.5	1.5	1.6	-0.5
Worrier / anxious feelings	0.2	0.3	0.4	0.4	0.6	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.5	-1.2	-0.7	-0.8
Falls in the last year	1.3	1.8	3.5	-1.3	-1.9	-0.4
Hair/balding pattern: Pattern 3	1.2	1.8	4.7	2.2	-0.5	-0.5
Number of live births	0.5	0.7	1.7	-1.3	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.8	-0.0	1.9	1.0
Pulse rate	0.7	1.2	3.4	-0.5	-0.1	-1.9
Happiness	0.6	0.8	1.3	-0.8	-0.7	1.1
Noisy workplace	1.6	2.0	3.3	-1.3	-1.0	1.8
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.6	0.6	1.9	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.4	-0.4	-0.4	-0.7
Mouth/teeth dental problems: Dentures	0.8	1.3	3.3	0.5	-1.8	0.5
Asthma	0.7	1.3	3.3	0.1	1.8	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.5	1.3	0.7	1.6
Medication: Cholesterol lowering	0.2	0.4	0.8	-0.9	0.5	0.1
Depression (self-reported)	0.3	0.3	0.8	0.2	0.9	-0.4
Medication: Lansoprazole	1.2	1.4	2.8	1.7	-0.6	1.0
Prospective memory result	0.0	0.0	0.1	-0.0	-0.2	-0.2
Lung cancer (father)	0.3	0.4	1.1	0.1	-1.0	0.2
Illnesses of mother	0.1	0.1	0.2	-0.4	0.4	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	7.0	0.1	2.6	1.8
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.4	-0.5	0.0
Impedance of arm (left)	0.2	0.8	1.1	-0.9	1.0	-0.7
Arm fat mass (right)	0.3	1.2	2.7	-0.3	-1.6	1.0
Trunk predicted mass	0.5	3.0	5.5	0.3	-1.9	2.3
Standing height	0.3	3.2	6.1	-0.1	-1.9	2.5
Length of working week for main job	1.5	1.6	2.7	-1.4	-0.6	1.6
Exposure to tobacco smoke at home	1.0	1.1	1.6	-1.1	-1.3	-0.7
Breastfed as a baby	4.9	6.1	9.9	2.0	3.1	2.1
Tense / ‘highly strung’	0.3	0.4	1.3	-0.1	0.1	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.1	-0.4	0.9	-1.0
Hair/balding pattern: Pattern 4	0.8	2.0	4.3	-0.2	-1.3	2.1
Birth weight of first child	0.9	1.6	4.5	-0.5	2.1	0.4
Peak expiratory flow (PEF)	1.2	2.8	7.3	-0.9	2.7	0.7
Pulse wave reflection index	0.6	0.8	1.4	1.2	0.9	-0.4
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.6	-1.6	0.3	0.2
Loud music exposure frequency	0.8	0.9	1.6	0.1	-1.0	-1.3
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.8	0.2	2.0	-0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	-0.7	-0.3	-0.6
Blood clot in the leg (DVT)	0.9	1.2	1.5	-1.2	-0.8	1.2
Medication: Paracetamol	0.6	1.0	1.5	-1.2	-1.2	0.5
Headache pain in last month	0.2	0.4	0.9	-0.9	0.1	0.6
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	0.2	-0.1	0.2
Glaucoma (self-reported)	2.7	3.2	6.9	-0.4	-1.6	-2.6
Gout (self-reported)	1.4	1.9	5.4	-0.4	-2.3	-0.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	3.4	1.2	-1.8	0.5
Medication: Amlodipine	0.3	0.5	0.9	-0.3	-0.7	0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	0.2	1.1	0.0
Birth weight	0.1	0.3	0.3	0.5	-0.6	-0.6
Chronic bronchitis/emphysema (mother)	0.6	0.8	1.8	-0.6	-1.3	0.4
High blood pressure (siblings)	0.4	0.6	0.8	0.8	-0.9	-0.7
Forced vital capacity (FVC), Best measure	1.2	4.5	9.5	0.3	3.1	2.0
Body fat percentage	0.3	1.0	2.1	-0.9	-1.4	0.4
Leg fat percentage (right)	0.2	0.9	1.5	-1.0	-1.2	0.3
Arm fat-free mass (right)	0.8	4.1	7.7	0.1	-2.1	2.8
Exposure to tobacco smoke outside home	2.0	2.7	6.3	0.1	-2.5	1.3
Comparative body size at age 10	0.4	1.1	2.5	-0.5	1.6	0.7
Number of full brothers	1.0	1.3	2.3	-1.5	-0.8	1.0
Worry too long after embarrassment	0.4	0.7	1.2	1.1	0.9	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	0.1	1.0	-1.0
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	-0.2	0.6	0.6
Number of children fathered	1.3	1.5	3.2	1.8	-1.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	3.6	1.8	1.9	-0.1
Age at first live birth	1.7	3.0	5.9	0.9	2.4	1.5
Pulse wave peak to peak time	0.1	0.1	0.3	-0.5	0.2	0.2
Health satisfaction	0.9	1.2	3.4	-1.9	-0.2	0.0
Shortness of breath walking on level ground	0.3	0.4	0.6	-0.6	-0.8	-0.6
Qualifications: College or University degree	1.5	4.8	14.0	0.1	3.7	0.5
Eye problems/disorders: None of the above	1.2	1.4	2.0	1.3	1.4	0.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	0.6	-1.1	-0.2
Emphysema/chronic bronchitis	1.3	1.5	2.2	1.5	-1.3	0.7
Medication for pain relief, constipation, heartburn	0.5	0.9	1.3	1.0	1.1	-0.6
Neck or shoulder pain in last month	3.7	5.2	10.9	-3.3	-2.1	0.4
Medication: Blood pressure	0.1	0.2	0.6	0.0	-0.8	-0.2
Angina (self-reported)	2.9	3.8	8.1	-2.8	0.5	1.8
Migraine (self-reported)	3.9	4.8	12.8	-3.6	1.3	0.3
Medication: Ibuprofen	0.9	1.1	2.3	1.5	0.2	1.0
Medication: Allopurinol	1.1	1.5	2.7	-1.2	-1.6	-0.7
Medication: Omeprazole	2.1	2.5	4.9	0.0	-1.6	-2.2
Medication: Seretide 50 evohaler	0.7	0.8	1.3	-0.4	-0.9	-1.2
Mean time to correctly identify matches	0.2	0.4	0.5	0.6	-0.5	-0.7
Heart disease (mother)	1.9	2.3	5.4	-1.1	0.6	2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.1	1.8	-0.4	0.8
Whole body fat mass	0.4	1.8	3.8	-0.7	-2.0	1.0
Leg fat mass (right)	0.5	2.0	3.9	-1.1	-2.0	1.0
Arm predicted mass (right)	0.7	3.7	7.1	0.1	-2.0	2.7
Pulse rate, automated reading	1.6	5.3	12.7	-0.9	-1.5	-3.6
Alcohol intake frequency.	0.6	1.4	3.2	0.2	-1.8	-1.0
Comparative height size at age 10	0.7	4.0	6.7	2.3	-0.6	2.6
Number of full sisters	2.4	2.9	4.3	2.0	-0.7	-2.1
Suffer from ‘nerves’	0.3	0.5	0.7	-0.9	-0.8	-0.5
Overall health rating	1.8	3.9	7.1	-2.2	-2.7	0.1
Chest pain or discomfort	0.1	0.1	0.2	0.2	-0.2	-0.4
Had major operations	0.9	1.1	3.2	0.1	-1.8	0.0
Age at last live birth	1.6	2.3	3.6	1.9	1.8	0.5
Family relationship satisfaction	1.2	1.5	1.9	-1.1	-1.2	1.4
Leg pain on walking	1.2	1.5	2.1	-0.9	-1.4	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.4	-1.5	-0.3	1.4
Commuting to job workplace: Car/motor vehicle	2.0	2.3	5.7	-2.4	-1.1	-0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	0.7	0.9	0.1
Medication: Aspirin	0.2	0.3	0.8	-0.3	0.1	0.9
Supplements: Vitamin C	1.3	1.5	3.5	0.2	1.9	1.0
Knee pain experienced in last month	1.6	2.6	4.7	-1.7	-2.2	-0.4
Hypertension (Self-reported)	0.4	1.2	2.6	0.4	-1.6	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.7	-1.3	0.8	-0.3
Illnesses of father: Heart disease	0.3	0.4	0.8	-0.2	0.9	0.6
Illnesses of siblings: Diabetes	1.3	1.6	4.8	0.1	0.3	-2.2
Smoking status: Previous	1.8	2.6	4.7	0.3	2.2	1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.6	0.3	0.5	1.6
Whole body fat-free mass	0.5	2.9	6.0	0.2	-1.7	2.4
Leg fat-free mass (right)	0.4	2.1	5.3	0.0	-0.9	2.3
Arm fat percentage (left)	0.2	0.8	1.2	-0.7	-1.1	0.7
Average weekly red wine intake	0.1	0.1	0.2	-0.5	-0.1	0.1
Handedness (chirality/laterality): Left-handed	2.0	2.5	3.4	-1.5	-1.9	-1.2
Mood swings	0.4	0.7	1.3	-0.8	-1.1	0.5
Loneliness, isolation	0.1	0.1	0.3	0.0	0.1	0.5
Long-standing illness, disability or infirmity	1.4	2.2	3.2	-1.7	-1.8	-0.6
Ever had bowel cancer screening	0.3	0.4	0.6	-0.4	0.7	-0.8
Diabetes diagnosed by doctor	1.7	2.7	6.3	1.3	0.4	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	-1.0	-0.7	0.1
Friendships satisfaction	1.6	2.0	5.7	-0.5	-0.3	2.4
Qualifications: nursing, teaching	0.6	1.0	2.2	-0.8	1.5	0.2
Commuting to job workplace: Walk	1.7	1.8	3.5	1.9	1.3	-0.4
Eye problems/disorders: Cataract	0.4	0.5	0.8	-0.7	-0.9	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.2	0.2	-0.4
Medication for cholesterol	0.3	0.4	0.4	-0.7	0.7	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	1.9	0.9	-1.4	-1.0
Back pain experienced in last month	1.4	2.0	3.5	-1.4	-1.9	0.7
Mineral and other dietary supplements	0.2	0.2	0.4	0.2	0.6	0.5
Breast cancer (self-reported)	0.9	1.1	2.5	-1.6	-0.3	-0.7
Asthma (self-reported)	0.5	1.0	2.3	0.0	1.5	0.8
Osteoporosis (self-reported)	1.4	1.7	3.7	-1.9	-0.9	-0.9
Osteoarthritis (self-reported)	1.8	2.3	6.7	-0.1	-2.6	-0.5
Medication: Aspirin	0.2	0.2	0.6	-0.1	-0.1	0.8
Medication: Gliclazide	1.8	2.1	3.7	0.6	1.5	-1.9
Illnesses of father: None of the above (group 1)	0.2	0.3	0.4	-0.6	-0.1	0.6
Smoking status: Current	0.5	0.8	1.9	0.2	-1.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	0.2	0.7	-0.0
Whole body water mass	0.5	3.0	5.9	0.3	-1.7	2.4
Leg predicted mass (right)	0.4	1.9	4.7	0.1	-1.0	2.2
Arm fat mass (left)	0.4	1.6	3.5	-0.4	-1.9	1.1
Number of self-reported non-cancer illnesses	0.7	1.1	1.6	-1.1	-1.3	0.8
Average weekly champagne plus white wine intake	0.7	1.0	1.5	-1.2	0.2	1.2
Miserableness	0.3	0.5	1.0	0.5	1.0	0.6
Guilty feelings	0.4	0.6	1.4	-0.3	0.5	1.2
Wears glasses or contact lenses	0.9	1.0	1.9	1.1	0.0	-1.4
Ever taken oral contraceptive pill	0.6	0.7	1.4	0.2	1.2	0.8
Hearing aid user	0.1	0.2	0.3	0.6	-0.1	-0.3
Mother’s age at death	0.6	0.7	2.0	1.4	0.1	0.4
Financial situation satisfaction	0.2	0.3	0.6	0.4	-0.8	-0.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	-0.6	0.7	0.5
Commuting to job workplace: Public transport	0.6	0.8	1.4	1.2	0.6	0.8
Eye problems/disorders: Glaucoma	2.9	3.4	6.8	-0.6	-1.7	-2.6
Medication: Blood pressure	1.3	2.4	5.8	0.6	-2.4	-1.1
Pain type(s) experienced in last month: Hip pain	1.3	1.6	4.0	-2.0	-0.9	0.3
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.7	0.3	-1.1	-1.3
High cholesterol (Self-reported)	0.6	1.1	2.2	-1.1	-0.1	1.5
Medication: Bendroflumethiazide	0.7	1.0	1.5	1.1	-1.2	-0.6
Medication: Paracetamol	1.2	1.9	4.5	-1.1	-2.1	0.1
Medication: Lisinopril	2.0	2.6	4.8	0.0	-2.2	-1.7
Medication: Atorvastatin	1.6	2.0	2.9	1.7	0.9	1.5
Illnesses of father: High blood pressure	2.9	3.6	5.9	2.4	-1.8	-1.3
Alcohol drinker status: Never	0.4	0.5	1.1	0.3	0.5	-1.1
Ever smoked	0.5	0.9	1.2	0.6	1.1	1.1
Basal metabolic rate	0.5	2.9	5.4	0.1	-1.8	2.3
Leg fat percentage (left)	0.4	1.3	2.1	-1.4	-0.9	0.9
Arm fat-free mass (left)	0.5	2.7	4.3	0.2	-2.0	2.1
Number of operations (self-reported)	0.8	1.1	2.4	-0.9	-1.5	-0.3
Average weekly beer plus cider intake	0.3	0.4	0.7	0.7	0.3	-0.9
Irritability	0.5	0.8	1.7	-1.3	-0.9	-0.2
Risk taking	0.7	1.0	1.8	-1.3	-0.8	-0.8
Ever had prostate specific antigen (PSA) test	2.1	2.4	3.1	1.5	1.8	-1.4
Fractured/broken bones in last 5 years	0.4	0.6	0.7	-0.6	-0.8	-0.8
Age started oral contraceptive pill	0.2	0.3	0.6	-0.4	-0.8	-0.0
Diastolic blood pressure, automated reading	1.0	3.2	6.2	-0.8	-2.5	-1.7
Ever depressed for a whole week	0.7	0.9	1.2	-0.8	-1.0	1.1
Unable to work because of sickness or disability	0.7	0.9	1.7	0.1	-1.3	-1.0
Commuting to job workplace: Cycle	2.3	2.7	6.9	0.9	0.7	2.6
Myopia	0.4	0.5	0.6	0.7	0.8	-0.6
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.4	-0.1	0.6	0.1
Cholesterol lowering medication	0.4	0.6	1.8	-0.2	-0.1	1.4
Medication: Omeprazole (e.g. Zanprol)	1.4	1.8	3.3	0.3	-1.4	-1.8
Pain experienced in last month	1.7	2.8	5.9	2.4	1.6	-0.1
Supplements: Calcium	1.0	1.1	2.4	-0.6	-1.6	-0.7
Basal cell carcinoma (self-reported)	0.7	0.8	1.6	0.9	1.2	0.1
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.0	-1.4	-1.1	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.1	-0.9	-1.1	0.9
Heart disease (siblings)	1.1	1.4	2.9	-0.7	-1.7	0.9
Alcohol drinker status: Previous	0.5	0.5	1.3	0.0	-0.5	-1.1
Pack years of smoking	0.6	0.8	2.1	-0.5	-1.5	-0.3
Impedance of whole body	0.2	0.8	1.5	-1.2	0.5	-0.8
Leg fat mass (left)	0.6	2.2	3.3	-1.2	-1.8	1.3
Arm predicted mass (left)	0.6	3.2	5.2	0.0	-2.3	2.1