Hub : Genes

RP11-588K22.2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.2200 0.0630 0.00019 0.106 NA 0.088 NA 0.108 2.0e-06 NA 1.5e-05 NA 1.6e-06
2 GTEx Nerve Tibial 0.1172 0.0417 0.00170 -0.004 NA -0.004 NA -0.004 7.6e-01 NA 8.5e-01 NA 9.3e-01
3 GTEx Thyroid 0.1060 0.0430 0.00830 0.050 NA 0.034 NA 0.051 1.1e-04 NA 1.1e-03 NA 9.0e-05
4 ROSMAP Brain Pre-frontal Cortex 0.0533 0.0213 0.00570 0.032 0.012 0.019 0.017 0.023 4.7e-05 0.01 1.4e-03 0.0028 5.5e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.1 0.1 0.3 -0.3 0.0 -0.4 -0.6
Bipolar Disorder or Schizophrenia 0.2 0.4 1.4 0.5 0.0 0.2 1.2
Depressed Affect (Nagel 2018) 0.9 2.0 6.0 -2.5 0.0 0.7 -1.2
Depression (Nagel 2018) 1.1 1.6 2.7 -1.5 0.0 -1.2 -1.7
Intelligence (Savage-Jansen 2018) 0.2 0.6 0.9 0.9 0.0 0.9 -0.9
Neuroticism (Nagel 2018) 1.3 3.1 11.2 -3.3 0.0 0.6 -0.9
Schizophrenia (2018) 0.6 1.3 4.0 0.9 0.0 0.6 2.0
Schizophrenia vs Biploar Disorder 0.8 1.1 3.8 0.3 0.0 0.7 1.9
Worry (Nagel 2018) 1.6 3.3 13.2 -3.6 0.0 -0.0 -0.3
Alzheimer’s Disease (in mother) 0.2 0.2 0.8 0.2 0.0 -0.9 0.1
Alzheimer’s Disease (in father) 1.3 1.4 5.1 2.3 0.0 -0.0 -0.7
Alzheimer’s Disease (including proxy) 1.2 1.7 4.9 2.2 0.0 -0.9 -1.0
Crohns Disease (2017) 1.2 2.7 5.3 2.3 0.0 1.6 -1.6
Irritable Bowel Disease (IBD) 0.9 2.2 6.4 2.5 0.0 1.0 -1.2
Ulcerative Colitis (UC) 0.5 1.0 3.7 1.9 0.0 0.4 0.3
Major Depression (MDD) 0.6 0.7 2.5 -1.6 0.0 -0.4 0.3
Reaction Time 1.1 2.0 6.0 2.4 0.0 -0.2 -1.5
Verbal and Numeric Reasoning (VNR) 0.5 1.1 2.5 1.4 0.0 0.2 -1.6
Breast Cancer 0.4 1.1 3.6 0.6 0.0 0.6 1.9
Ovarian Cancer 1.0 1.4 2.8 -0.1 0.0 1.7 -1.6
Prostate Cancer 0.7 1.0 3.2 -0.6 0.0 0.5 1.8
Age at First Birth 0.8 1.2 4.2 0.8 0.0 -0.3 -2.0
Bipolar Disorder (2011) 0.1 0.1 0.4 -0.1 0.0 0.7 0.3
Body Mass Index (BMI) (2010) 0.7 0.9 1.7 1.0 0.0 1.0 1.3
Coronary Artery Disease (CAD) 1.0 1.2 4.0 -2.0 0.0 -0.7 -0.5
Crohns Disease (2012) 0.9 1.4 3.9 0.7 0.0 1.1 -2.0
Mean Putamen Volume 0.0 0.0 0.1 0.0 0.0 -0.3 0.2
Fasting Glucose 2.1 2.5 6.4 -0.1 0.0 -2.5 -1.9
HbA1C 0.1 0.1 0.2 0.4 0.0 0.1 -0.3
HDL Cholesterol 0.1 0.2 0.4 -0.7 0.0 0.3 -0.4
LDL Cholesterol 0.3 0.5 1.9 0.0 0.0 1.4 -0.1
Lupus 1.2 1.9 6.8 2.6 0.0 0.5 0.7
Neuroticism (2016) 1.5 2.2 8.0 -2.8 0.0 -0.1 0.8
Primary Biliary Cirrhosis 0.3 0.4 1.0 0.3 0.0 -1.0 -0.8
Rheumatoid Arthritis 0.1 0.1 0.3 0.6 0.0 -0.1 -0.4
Schizophrenia (2014) 0.5 1.1 4.2 -0.2 0.0 0.5 2.1
Triglycerides 0.1 0.2 0.4 0.7 0.0 0.2 0.4
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.6 0.0 0.0 -0.5 -1.3
Ulcerative Colitis 0.2 0.3 0.9 0.9 0.0 -0.5 -0.2
Blood Eosinophil Count 0.1 0.5 2.0 0.2 0.0 -1.4 -0.3
Blood Platelet Count 0.2 1.8 5.8 2.4 0.0 -0.0 -1.1
Blood Red Count 0.3 3.2 10.7 -1.1 0.0 -0.8 -3.3
Blood White Count 0.2 1.5 6.2 0.2 0.0 -2.5 0.1
Heel T-Score 0.0 0.4 1.0 -1.0 0.0 0.5 0.4
BMI 0.1 0.3 0.9 0.6 0.0 0.2 0.9
Height 0.1 1.3 5.2 2.3 0.0 -0.3 0.3
Waist Hip Ratio (WHR) 0.2 0.8 2.6 0.4 0.0 0.5 1.6
Systolic Blood Pressure 8.7 43.5 141.6 -11.9 0.0 -2.1 -5.3
Smoking Status 0.0 0.0 0.1 0.2 0.0 -0.1 -0.3
Allergy or Eczema 0.6 1.7 3.0 1.3 0.0 1.4 1.7
Cardiovascular Disease 5.0 16.4 50.7 -7.1 0.0 -2.4 -3.1
Hypothyroidism (self reported) 0.8 1.8 5.8 -1.2 0.0 0.3 -2.4
Respiratory disease 0.3 0.7 1.5 1.2 0.0 0.8 0.9
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.1 -1.0 0.0 -0.7 -1.5
Lung FEV1/FVC ratio 0.3 1.7 3.7 -1.8 0.0 -1.9 -0.2
Lung FVC 0.3 1.6 3.6 -1.9 0.0 0.9 -1.5
Neuroticism 1.1 2.7 9.7 -3.1 0.0 0.7 0.7
Chronotype (morning person) 0.4 1.0 2.0 -1.4 0.0 -0.3 -1.4
Hair Pigment 0.0 1.4 4.8 0.6 0.0 0.7 2.2
Tanning 0.1 1.1 3.9 2.0 0.0 0.7 -0.0
Hand grip strength (left) 0.1 0.2 0.6 0.8 0.0 0.4 0.2
Number of treatments/medications taken 2.0 3.6 8.2 -2.4 0.0 -2.9 -0.8
Average weekly spirits intake 0.2 0.3 0.5 0.7 0.0 -0.7 -0.2
Sensitivity / hurt feelings 0.4 0.7 1.7 -0.9 0.0 0.3 -1.3
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.2 -1.1 0.0 -0.5 -0.7
Hearing difficulty/problems: Yes 0.1 0.2 0.7 -0.1 0.0 -0.8 0.3
Relative age of first facial hair 0.2 0.5 1.4 0.3 0.0 -1.2 -0.7
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 2.2 -0.5 0.0 -0.0 1.5
Ever used hormone-replacement therapy (HRT) 0.5 0.6 2.3 -1.5 0.0 0.1 0.1
Ever had hysterectomy (womb removed) 0.7 0.8 3.0 -0.5 0.0 -0.2 1.7
Systolic blood pressure, automated reading 6.1 17.6 54.8 -7.4 0.0 -1.0 -3.8
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 2.8 -1.7 0.0 0.1 0.2
Angina 0.6 0.8 1.7 -0.6 0.0 -1.1 -1.3
Medication for hormone replacement therapy 0.2 0.2 0.5 -0.3 0.0 0.7 0.4
Vitamin and mineral supplements 1.8 2.5 5.6 -2.1 0.0 0.2 -2.4
Supplements: Zinc 0.8 0.8 2.4 0.2 0.0 -1.0 1.6
Medication: Co-codamol 0.6 0.7 2.3 -0.6 0.0 -1.5 0.2
Medication: Metformin 1.7 2.4 5.2 -2.3 0.0 -0.7 -1.9
Diabetes (father) 0.9 1.1 2.5 -1.3 0.0 0.1 -1.6
Diabetes (mother) 1.9 2.4 8.4 -0.1 0.0 -1.2 -2.9
Severe depression (siblings) 1.0 1.1 2.7 0.4 0.0 -1.3 -1.6
Pack years adult smoking proportion 1.4 2.1 3.4 1.8 0.0 -1.9 1.4
Impedance of leg (right) 0.1 0.5 1.0 -0.9 0.0 1.0 -0.3
Leg fat-free mass (left) 0.3 1.6 5.4 2.3 0.0 -0.8 0.6
Trunk fat percentage 0.0 0.1 0.3 0.1 0.0 0.5 0.4
Hand grip strength (right) 0.3 0.7 1.7 1.3 0.0 1.0 -0.1
Townsend deprivation index at recruitment 0.4 0.5 1.5 0.7 0.0 -0.1 1.2
Current tobacco smoking 0.4 0.7 1.3 1.0 0.0 -1.2 0.6
Average weekly fortified wine intake 0.8 0.9 2.3 -1.5 0.0 0.7 1.0
Maternal smoking around birth 0.5 0.7 1.8 0.2 0.0 -1.0 1.3
Fed-up feelings 0.4 0.8 2.1 -1.4 0.0 0.7 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 3.2 -1.5 0.0 -1.8 -1.7
Relative age voice broke 0.3 0.4 1.1 1.1 0.0 -0.3 0.8
Taking other prescription medications 0.3 0.4 1.7 -1.3 0.0 0.1 -0.3
Age when periods started (menarche) 0.4 0.9 2.8 0.8 0.0 -1.7 -0.2
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.4 -1.6 0.0 0.3 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.4 0.6 0.0 -0.2 0.2
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.1 0.3 0.0 -1.0 -0.4
Qualifications: CSEs or equivalent 0.3 0.4 0.6 0.5 0.0 -0.8 0.8
Serious illness, injury or assault to yourself 0.7 0.9 1.8 -1.1 0.0 -0.8 1.3
High blood pressure 4.0 11.3 31.2 -5.6 0.0 -2.2 -3.0
Hayfever, allergic rhinitis or eczema 0.9 1.9 4.5 0.5 0.0 1.6 2.1
Multivitamins +/- minerals 1.1 1.3 4.3 2.1 0.0 0.3 1.0
Stomach or abdominal pain in last month 0.5 0.6 1.4 -0.4 0.0 1.2 1.0
Supplements: Glucosamine 1.3 1.6 5.1 0.6 0.0 1.1 2.2
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.7 0.5 0.0 1.3 0.4
Medication: Atenolol 1.8 2.3 4.7 -0.9 0.0 -1.9 -2.2
Medication: Levothyroxine sodium 1.2 2.0 4.1 -1.0 0.0 1.6 -2.0
Sitting height 0.1 0.9 2.8 1.7 0.0 -0.9 -0.3
Chronic bronchitis/emphysema (father) 0.7 0.8 2.8 -0.5 0.0 -1.7 -0.6
High blood pressure (mother) 0.9 1.3 4.1 -2.0 0.0 -0.8 -0.6
Body mass index (BMI) 0.0 0.1 0.4 0.6 0.0 0.2 0.2
Impedance of leg (left) 0.2 0.7 1.8 -1.3 0.0 0.7 -0.8
Leg predicted mass (left) 0.3 1.7 5.9 2.4 0.0 -0.7 0.6
Trunk fat mass 0.1 0.3 0.7 0.8 0.0 0.2 0.7
Waist circumference 0.2 0.8 2.1 1.5 0.0 0.5 1.0
Number of incorrect matches in round 0.3 0.4 1.4 0.2 0.0 -1.2 0.6
Past tobacco smoking 0.7 1.3 4.5 2.1 0.0 -0.6 -0.6
Alcohol usually taken with meals 0.4 0.7 1.9 1.4 0.0 -0.3 -0.8
Nervous feelings 1.1 2.1 8.5 -2.9 0.0 -0.1 -0.0
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 4.9 -2.2 0.0 -0.1 -1.7
Hearing difficulty/problems with background noise 0.6 0.9 3.1 -1.8 0.0 -0.2 0.7
Hair/balding pattern: Pattern 2 1.2 1.6 5.8 -0.2 0.0 -0.7 -2.4
Had menopause 0.6 0.7 1.6 -0.9 0.0 0.8 -1.3
Had other major operations 0.7 0.9 2.4 -1.1 0.0 0.2 -1.6
Forced vital capacity (FVC) 0.1 0.4 0.8 -0.8 0.0 0.9 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.5 -0.7 0.0 0.5 0.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.6 -1.2 0.0 1.2 -0.3
Qualifications: None of the above 0.7 1.4 3.7 -1.2 0.0 -1.9 -0.7
Financial difficulties in last 2 years 0.3 0.4 0.6 -0.7 0.0 -0.8 0.6
Mouth/teeth dental problems 0.5 0.8 2.6 -1.6 0.0 -0.4 -0.8
Heart attack 3.2 4.0 7.4 -2.7 0.0 -2.4 -1.7
Allergy 0.6 1.5 4.1 -1.2 0.0 -0.5 -2.0
Pain all over the body in last month 0.8 0.9 2.8 -1.7 0.0 -0.9 0.0
Diabetes (self-reported) 0.5 0.8 2.2 -1.5 0.0 0.1 -1.0
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.7 -0.9 0.0 -0.1 -0.1
Medication: Ramipril 2.0 2.6 4.7 -2.2 0.0 -1.3 -2.0
Medication: Simvastatin 2.9 4.3 10.5 -3.2 0.0 -2.5 0.5
Fluid intelligence score 0.8 1.8 4.9 2.2 0.0 1.1 -1.0
Illnesses of siblings 1.6 2.2 8.6 0.5 0.0 0.2 2.9
Neuroticism score 1.1 2.3 8.8 -3.0 0.0 0.5 0.3
Weight 0.2 1.0 3.5 1.9 0.0 -0.3 0.4
Impedance of arm (right) 0.1 0.3 0.6 -0.8 0.0 0.6 -0.5
Arm fat percentage (right) 0.0 0.2 0.3 0.5 0.0 0.4 0.5
Trunk fat-free mass 0.5 2.9 10.6 3.3 0.0 -0.6 0.7
Hip circumference 0.1 0.6 2.1 1.4 0.0 -0.2 0.4
Time employed in main current job 0.4 0.4 1.6 -0.2 0.0 0.3 -1.3
Alcohol intake versus 10 years previously 0.3 0.4 1.3 -0.3 0.0 -1.1 0.5
Father’s age at death 1.0 1.3 2.9 0.2 0.0 1.5 1.7
Worrier / anxious feelings 1.4 2.6 9.8 -3.1 0.0 -0.3 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.3 -1.1 0.0 0.2 0.1
Falls in the last year 0.5 0.6 2.2 -0.3 0.0 -1.5 -0.4
Hair/balding pattern: Pattern 3 0.1 0.2 0.5 0.3 0.0 -0.4 0.7
Number of live births 0.6 0.9 2.3 0.6 0.0 -1.5 -1.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.8 -1.1 0.0 0.3 -1.4
Pulse rate 0.6 0.9 2.1 0.4 0.0 1.3 1.4
Happiness 0.1 0.1 0.6 -0.8 0.0 -0.0 -0.0
Noisy workplace 0.4 0.5 2.0 -1.4 0.0 0.4 0.1
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.4 -0.5 0.0 0.3 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.5 -0.2 0.0 0.1 0.7
Mouth/teeth dental problems: Dentures 0.4 0.7 1.6 1.3 0.0 -0.4 -0.9
Asthma 0.5 1.0 3.5 0.5 0.0 0.6 1.9
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 2.0 1.4 0.0 -0.2 -0.3
Medication: Cholesterol lowering 3.2 4.9 10.2 -3.2 0.0 -2.9 -1.0
Depression (self-reported) 0.1 0.1 0.2 0.3 0.0 -0.5 0.4
Medication: Lansoprazole 0.2 0.3 0.6 -0.8 0.0 -0.6 -0.1
Prospective memory result 0.3 0.3 0.6 -0.8 0.0 0.8 -0.2
Lung cancer (father) 0.7 0.8 3.1 -0.4 0.0 -1.8 -0.1
Illnesses of mother 1.9 2.4 4.3 2.1 0.0 1.8 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 3.6 -1.9 0.0 -0.0 -1.3
Pulse wave Arterial Stiffness index 0.9 1.0 3.9 0.0 0.0 0.4 2.0
Impedance of arm (left) 0.2 0.8 2.2 -1.5 0.0 0.5 -1.0
Arm fat mass (right) 0.1 0.4 1.4 1.2 0.0 0.0 0.3
Trunk predicted mass 0.5 2.7 10.2 3.2 0.0 -0.5 0.6
Standing height 0.2 2.0 7.5 2.7 0.0 -0.7 0.4
Length of working week for main job 0.1 0.1 0.2 -0.2 0.0 -0.4 0.3
Exposure to tobacco smoke at home 1.5 1.7 4.9 -0.8 0.0 -1.2 2.2
Breastfed as a baby 0.7 0.8 1.7 -1.0 0.0 -1.3 -0.8
Tense / ‘highly strung’ 0.9 1.5 5.4 -2.3 0.0 -0.0 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 2.1 -1.5 0.0 0.5 0.3
Hair/balding pattern: Pattern 4 0.6 1.5 4.7 -1.1 0.0 2.2 0.0
Birth weight of first child 1.7 3.1 7.7 1.8 0.0 1.3 2.8
Peak expiratory flow (PEF) 0.1 0.3 0.6 -0.4 0.0 0.7 -0.7
Pulse wave reflection index 0.1 0.1 0.3 0.2 0.0 -0.5 0.4
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.0 -0.1 0.0 1.0 0.1
Loud music exposure frequency 0.7 0.8 1.6 -1.1 0.0 0.5 -1.3
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 2.2 -1.4 0.0 1.5 -0.0
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.3 -0.5 0.0 1.1 0.9
Blood clot in the leg (DVT) 0.6 0.8 3.0 1.7 0.0 -0.3 0.3
Medication: Paracetamol 0.8 1.3 4.8 2.2 0.0 -0.0 0.5
Headache pain in last month 0.6 0.9 3.6 1.9 0.0 -0.2 0.4
Medication for cholesterol, blood pressure or diabetes 4.8 8.0 17.6 4.2 0.0 3.3 1.8
Glaucoma (self-reported) 0.5 0.6 0.8 0.9 0.0 -0.8 0.9
Gout (self-reported) 0.0 0.0 0.0 -0.0 0.0 -0.2 0.1
Hypothyroidism/myxoedema (self-reported) 1.3 2.5 7.0 -1.3 0.0 1.1 -2.6
Medication: Amlodipine 3.0 4.2 11.0 -3.3 0.0 0.1 -2.4
Medication: Ventolin 100micrograms inhaler 1.9 2.4 5.3 2.3 0.0 2.1 0.1
Birth weight 1.2 2.7 8.6 1.3 0.0 2.9 0.7
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.9 -0.2 0.0 0.9 -0.1
High blood pressure (siblings) 1.1 1.6 5.0 -0.9 0.0 -0.7 -2.2
Forced vital capacity (FVC), Best measure 0.2 0.8 1.6 -1.3 0.0 0.9 -0.8
Body fat percentage 0.0 0.1 0.2 0.4 0.0 0.3 0.4
Leg fat percentage (right) 0.0 0.1 0.3 0.5 0.0 0.2 0.5
Arm fat-free mass (right) 0.3 1.4 5.3 2.3 0.0 -0.3 0.5
Exposure to tobacco smoke outside home 0.2 0.3 0.7 -0.4 0.0 -0.8 0.7
Comparative body size at age 10 0.2 0.5 1.5 -0.6 0.0 1.2 0.3
Number of full brothers 0.3 0.4 1.5 0.1 0.0 -0.1 -1.2
Worry too long after embarrassment 0.4 0.6 1.4 -1.0 0.0 -1.2 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.5 -1.6 0.0 0.5 0.4
Wheeze or whistling in the chest in last year 0.4 0.7 1.3 1.0 0.0 -0.6 1.1
Number of children fathered 0.8 0.9 3.3 -1.8 0.0 -0.3 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 2.2 -1.5 0.0 0.3 1.4
Age at first live birth 1.0 1.8 4.9 0.8 0.0 1.4 2.2
Pulse wave peak to peak time 1.0 1.2 4.5 0.1 0.0 -0.6 -2.1
Health satisfaction 0.3 0.4 0.8 -0.9 0.0 -0.9 0.2
Shortness of breath walking on level ground 0.8 0.9 3.4 0.4 0.0 -1.8 -0.3
Qualifications: College or University degree 0.2 0.5 1.4 0.2 0.0 -0.8 1.2
Eye problems/disorders: None of the above 0.0 0.0 0.1 -0.3 0.0 0.3 -0.1
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.1 0.0 0.0 0.1 0.2
Emphysema/chronic bronchitis 1.3 1.5 4.1 0.7 0.0 2.0 1.2
Medication for pain relief, constipation, heartburn 0.2 0.3 0.9 -0.6 0.0 0.9 -0.3
Neck or shoulder pain in last month 0.7 0.9 2.6 -1.6 0.0 1.1 -0.2
Medication: Blood pressure 3.8 6.7 13.0 -3.6 0.0 -2.8 -2.4
Angina (self-reported) 0.7 0.9 1.9 -0.7 0.0 -1.1 -1.4
Migraine (self-reported) 0.1 0.2 0.5 0.7 0.0 0.2 0.3
Medication: Ibuprofen 0.5 0.6 2.3 1.5 0.0 0.2 -0.1
Medication: Allopurinol 0.2 0.2 0.4 -0.6 0.0 -0.2 0.7
Medication: Omeprazole 0.9 1.0 2.9 -0.6 0.0 0.9 1.7
Medication: Seretide 50 evohaler 0.8 1.0 3.9 2.0 0.0 0.0 -0.1
Mean time to correctly identify matches 0.7 1.3 3.8 1.9 0.0 -0.7 -0.9
Heart disease (mother) 3.4 4.1 8.9 -3.0 0.0 -2.7 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 -0.2 0.0 0.4 0.3
Whole body fat mass 0.1 0.3 0.9 0.9 0.0 -0.1 0.5
Leg fat mass (right) 0.1 0.3 0.9 1.0 0.0 -0.0 0.5
Arm predicted mass (right) 0.4 2.0 7.1 2.7 0.0 -0.4 0.7
Pulse rate, automated reading 1.2 3.7 8.5 1.4 0.0 2.9 2.1
Alcohol intake frequency. 0.6 1.5 4.1 1.3 0.0 -0.2 -2.0
Comparative height size at age 10 0.1 0.4 1.0 1.0 0.0 -0.2 -0.8
Number of full sisters 0.1 0.1 0.2 -0.0 0.0 -0.3 0.4
Suffer from ‘nerves’ 0.7 1.1 4.1 -2.0 0.0 -0.4 -0.4
Overall health rating 0.2 0.4 1.5 0.0 0.0 -1.2 0.4
Chest pain or discomfort 0.4 0.6 1.0 1.0 0.0 -0.6 -0.9
Had major operations 0.5 0.6 1.7 0.9 0.0 -1.3 0.2
Age at last live birth 0.5 0.7 1.4 1.1 0.0 0.2 1.2
Family relationship satisfaction 0.3 0.3 0.6 -0.8 0.0 0.3 0.7
Leg pain on walking 2.4 3.1 7.3 -1.9 0.0 -2.7 1.2
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.0 -1.0 0.0 0.7 -0.6
Commuting to job workplace: Car/motor vehicle 1.2 1.3 5.0 -2.2 0.0 0.5 -0.3
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 2.7 -0.1 0.0 -0.4 -1.6
Medication: Aspirin 1.1 1.5 3.6 -1.4 0.0 -1.9 -0.7
Supplements: Vitamin C 0.8 0.9 2.8 0.7 0.0 -0.5 1.7
Knee pain experienced in last month 0.6 0.9 2.2 1.5 0.0 -1.2 0.0
Hypertension (Self-reported) 4.0 11.2 28.3 -5.3 0.0 -2.3 -3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 4.1 -0.2 0.0 2.0 1.1
Illnesses of father: Heart disease 1.3 1.8 2.6 -1.5 0.0 -1.5 -1.6
Illnesses of siblings: Diabetes 0.0 0.1 0.2 0.1 0.0 0.4 0.1
Smoking status: Previous 0.7 1.0 1.8 -1.3 0.0 1.4 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.6 0.3 0.0 0.8 1.6
Whole body fat-free mass 0.4 2.3 8.2 2.9 0.0 -0.8 0.6
Leg fat-free mass (right) 0.3 1.4 4.8 2.2 0.0 -0.8 0.4
Arm fat percentage (left) 0.0 0.1 0.2 0.5 0.0 0.4 0.2
Average weekly red wine intake 0.2 0.4 1.3 -1.1 0.0 0.1 0.3
Handedness (chirality/laterality): Left-handed 1.7 2.0 7.6 0.1 0.0 0.8 2.8
Mood swings 0.3 0.6 1.6 -0.9 0.0 1.3 -0.2
Loneliness, isolation 1.1 1.5 5.0 -2.2 0.0 -0.3 -0.8
Long-standing illness, disability or infirmity 0.1 0.1 0.3 0.3 0.0 -0.6 -0.4
Ever had bowel cancer screening 1.2 1.3 2.9 0.6 0.0 -1.5 1.7
Diabetes diagnosed by doctor 0.6 0.9 1.8 -1.4 0.0 -0.1 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.6 0.8 0.0 0.1 -0.3
Friendships satisfaction 0.5 0.6 2.1 -1.4 0.0 -0.2 0.5
Qualifications: nursing, teaching 0.3 0.4 1.2 1.1 0.0 0.4 0.6
Commuting to job workplace: Walk 0.9 1.0 2.4 1.6 0.0 0.6 1.1
Eye problems/disorders: Cataract 0.5 0.6 2.2 1.5 0.0 -0.0 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.2 0.5 0.0 0.1 0.1
Medication for cholesterol 1.5 2.3 6.2 2.5 0.0 0.3 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.3 3.5 -1.8 0.0 1.9 1.6
Back pain experienced in last month 0.4 0.6 2.1 0.7 0.0 1.4 0.0
Mineral and other dietary supplements 0.7 0.9 3.5 -0.2 0.0 0.2 -1.9
Breast cancer (self-reported) 0.1 0.2 0.3 -0.1 0.0 0.6 0.6
Asthma (self-reported) 0.3 0.6 1.9 0.5 0.0 0.5 1.4
Osteoporosis (self-reported) 0.1 0.1 0.2 -0.4 0.0 -0.2 0.3
Osteoarthritis (self-reported) 0.1 0.1 0.4 0.6 0.0 -0.3 -0.0
Medication: Aspirin 1.3 1.7 3.8 -1.4 0.0 -2.0 -0.9
Medication: Gliclazide 1.2 1.4 2.4 -1.5 0.0 -0.9 -1.5
Illnesses of father: None of the above (group 1) 3.2 4.0 6.2 1.9 0.0 2.4 2.5
Smoking status: Current 0.3 0.5 1.1 0.9 0.0 -1.1 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.9 -1.0 0.0 -0.4 0.1
Whole body water mass 0.4 2.4 8.6 2.9 0.0 -0.8 0.6
Leg predicted mass (right) 0.3 1.4 4.8 2.2 0.0 -0.9 0.4
Arm fat mass (left) 0.1 0.3 1.2 1.1 0.0 0.0 0.1
Number of self-reported non-cancer illnesses 1.2 2.1 7.6 -2.8 0.0 -0.7 0.7
Average weekly champagne plus white wine intake 0.1 0.2 0.3 -0.5 0.0 0.4 0.5
Miserableness 0.7 1.3 3.6 -1.9 0.0 0.7 -1.0
Guilty feelings 0.6 0.9 2.1 -1.4 0.0 1.0 0.6
Wears glasses or contact lenses 0.1 0.1 0.5 0.2 0.0 0.2 -0.7
Ever taken oral contraceptive pill 0.7 0.7 2.3 1.5 0.0 0.4 0.7
Hearing aid user 0.7 0.8 3.0 -0.6 0.0 0.2 1.7
Mother’s age at death 2.0 2.4 6.7 1.3 0.0 1.1 2.6
Financial situation satisfaction 0.6 0.7 2.2 -1.5 0.0 -0.8 0.4
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 -0.5 0.0 0.4 0.0
Commuting to job workplace: Public transport 1.0 1.2 2.5 1.6 0.0 0.9 1.2
Eye problems/disorders: Glaucoma 0.3 0.3 0.7 0.6 0.0 -0.5 0.8
Medication: Blood pressure 3.8 7.3 20.1 -4.5 0.0 -0.8 -2.9
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.4 -0.8 0.0 -0.6 1.2
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.5 -0.4 0.0 0.3 0.7
High cholesterol (Self-reported) 1.2 2.2 6.8 -2.6 0.0 -1.4 -0.1
Medication: Bendroflumethiazide 2.7 4.1 12.7 -3.6 0.0 -1.0 -1.6
Medication: Paracetamol 0.5 0.8 3.1 1.8 0.0 -0.5 0.0
Medication: Lisinopril 1.6 2.0 4.9 -2.2 0.0 -1.1 -1.4
Medication: Atorvastatin 4.7 5.9 12.6 -2.7 0.0 -1.9 -3.5
Illnesses of father: High blood pressure 2.0 2.5 5.4 -2.3 0.0 -0.4 -2.1
Alcohol drinker status: Never 0.3 0.4 1.5 1.2 0.0 0.3 -0.1
Ever smoked 0.7 1.3 4.8 -2.2 0.0 0.5 0.2
Basal metabolic rate 0.4 2.2 8.1 2.8 0.0 -0.7 0.6
Leg fat percentage (left) 0.0 0.1 0.1 0.3 0.0 0.2 0.3
Arm fat-free mass (left) 0.4 1.8 6.9 2.6 0.0 -0.5 0.4
Number of operations (self-reported) 0.2 0.3 1.0 -0.2 0.0 -1.0 -0.2
Average weekly beer plus cider intake 0.3 0.4 0.8 -0.9 0.0 0.9 0.0
Irritability 0.7 1.2 2.5 -1.6 0.0 1.5 0.5
Risk taking 1.2 1.8 3.6 1.9 0.0 -1.8 -0.5
Ever had prostate specific antigen (PSA) test 1.1 1.3 4.7 0.3 0.0 -0.5 2.2
Fractured/broken bones in last 5 years 0.2 0.3 0.8 -0.9 0.0 0.3 0.6
Age started oral contraceptive pill 0.6 0.8 1.9 -0.8 0.0 1.4 0.7
Diastolic blood pressure, automated reading 2.5 7.8 22.7 -1.9 0.0 -2.1 -4.8
Ever depressed for a whole week 0.8 1.0 2.4 -1.6 0.0 0.7 1.0
Unable to work because of sickness or disability 0.0 0.0 0.0 0.0 0.0 -0.2 -0.1
Commuting to job workplace: Cycle 0.3 0.4 1.0 0.6 0.0 -1.0 0.6
Myopia 0.5 0.7 2.1 -1.5 0.0 -0.8 -0.2
Vascular/heart problems diagnosed by doctor 4.5 12.2 35.6 6.0 0.0 2.6 2.6
Cholesterol lowering medication 0.7 1.1 3.4 -1.8 0.0 -0.9 -0.5
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 2.8 -0.4 0.0 1.7 1.6
Pain experienced in last month 0.6 1.1 2.3 -1.4 0.0 0.3 -1.5
Supplements: Calcium 0.6 0.7 1.6 -0.0 0.0 1.3 1.0
Basal cell carcinoma (self-reported) 0.1 0.1 0.3 -0.0 0.0 0.2 0.5
Heart attack/myocardial infarction (self-reported) 3.0 3.8 6.7 -2.6 0.0 -2.4 -1.7
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.9 1.7 0.0 -0.3 0.6
Heart disease (siblings) 2.5 3.1 7.6 -2.8 0.0 -0.9 -2.0
Alcohol drinker status: Previous 0.6 0.7 2.0 1.4 0.0 -0.3 -0.8
Pack years of smoking 1.2 1.8 2.9 1.7 0.0 -1.7 1.2
Impedance of whole body 0.2 0.8 2.5 -1.6 0.0 0.7 -0.5
Leg fat mass (left) 0.1 0.2 0.7 0.8 0.0 0.0 0.3
Arm predicted mass (left) 0.4 2.0 7.4 2.7 0.0 -0.5 0.6