Hub : Genes

RP11-611L7.1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.0840	0.0320	3.5e-03	0.029	NA	0.014	NA	0.019	9.5e-04	NA	1.7e-02	NA	6.8e-03
2	METSIM	Adipose	0.0719	0.0302	1.4e-03	0.025	0.016	0.027	0.026	0.037	9.5e-05	1.4e-03	5.0e-05	7.7e-05	2.5e-06
3	ROSMAP	Brain Pre-frontal Cortex	0.1906	0.0372	1.2e-14	0.183	0.108	0.153	0.063	0.080	5.2e-23	8.9e-14	3.9e-19	1.4e-08	1.7e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.4	-0.1	0.7	-0.6
Bipolar Disorder or Schizophrenia	0.9	2.3	3.8	-2.0	-1.7	-0.4
Depressed Affect (Nagel 2018)	1.2	2.5	4.1	-1.4	1.3	-2.0
Depression (Nagel 2018)	1.8	2.7	4.1	-0.6	1.9	-2.0
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.9	1.4	0.5	0.8
Neuroticism (Nagel 2018)	0.5	1.1	2.0	-0.2	1.1	-1.4
Schizophrenia (2018)	2.1	4.4	7.2	-2.4	-2.7	-0.1
Schizophrenia vs Biploar Disorder	3.0	3.9	6.6	-2.3	-0.1	-2.6
Worry (Nagel 2018)	0.0	0.1	0.2	0.4	-0.2	-0.1
Alzheimer’s Disease (in mother)	0.7	0.8	2.3	-0.0	-0.3	1.5
Alzheimer’s Disease (in father)	0.8	0.9	1.2	-1.1	-0.9	-0.9
Alzheimer’s Disease (including proxy)	0.9	1.4	2.7	-0.7	-0.9	1.7
Crohns Disease (2017)	1.1	2.4	3.8	0.1	1.9	-1.9
Irritable Bowel Disease (IBD)	1.0	2.5	4.2	-0.2	1.8	-2.1
Ulcerative Colitis (UC)	0.5	0.9	1.7	-0.1	0.9	-1.3
Major Depression (MDD)	1.2	1.4	1.8	1.0	1.2	1.3
Reaction Time	0.4	0.8	1.3	0.1	-1.1	1.0
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.2	0.3	0.4	-0.5
Breast Cancer	0.3	0.7	1.3	0.4	1.1	-0.7
Ovarian Cancer	2.2	3.0	6.4	2.5	0.8	1.4
Prostate Cancer	0.4	0.5	1.2	-0.4	-0.5	-1.1
Age at First Birth	0.1	0.2	0.4	-0.4	-0.6	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.7	3.7	6.7	-2.6	-0.5	-2.0
Coronary Artery Disease (CAD)	0.8	1.0	1.4	-0.8	-1.2	-1.0
Crohns Disease (2012)	1.1	1.8	3.9	0.4	2.0	-1.1
Mean Putamen Volume	0.5	0.6	1.1	-0.8	1.1	-0.4
Fasting Glucose	0.7	0.9	2.2	-0.6	-1.5	0.2
HbA1C	1.0	1.1	2.5	0.7	-0.6	-1.6
HDL Cholesterol	0.3	0.4	0.8	0.9	-0.3	0.7
LDL Cholesterol	0.4	0.6	0.9	-0.7	0.6	-1.0
Lupus	0.5	0.7	1.9	0.5	1.4	0.2
Neuroticism (2016)	0.3	0.5	0.7	-0.1	0.8	-0.8
Primary Biliary Cirrhosis	1.4	1.9	4.5	-2.1	-1.1	-0.4
Rheumatoid Arthritis	0.6	0.8	1.0	-0.7	1.0	-0.9
Schizophrenia (2014)	1.2	2.5	4.8	-2.2	-1.7	-0.2
Triglycerides	0.3	0.5	0.9	-1.0	-0.8	0.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.2	0.8	0.0	1.5
Ulcerative Colitis	0.1	0.2	0.4	0.4	0.6	-0.1
Blood Eosinophil Count	0.2	1.9	4.0	-2.0	-0.9	-1.0
Blood Platelet Count	0.4	4.3	7.1	-2.7	-0.9	-2.3
Blood Red Count	0.5	4.4	9.4	-3.1	-0.1	-2.0
Blood White Count	3.8	28.2	59.3	-4.7	1.8	-7.7
Heel T-Score	0.7	5.4	6.8	2.1	2.2	2.6
BMI	1.5	8.9	18.9	-4.3	1.0	-2.6
Height	0.3	5.0	6.1	2.2	2.0	2.5
Waist Hip Ratio (WHR)	0.3	1.1	2.0	-0.8	-1.4	-0.8
Systolic Blood Pressure	0.6	2.8	4.0	-2.0	-2.0	-0.8
Smoking Status	0.7	1.6	4.5	-0.4	-0.3	-2.1
Allergy or Eczema	0.5	1.4	1.7	1.3	1.3	-0.8
Cardiovascular Disease	1.2	3.9	5.7	-2.4	-1.4	-2.0
Hypothyroidism (self reported)	0.6	1.4	4.2	-2.0	-0.2	-0.1
Respiratory disease	3.5	7.8	11.9	-2.1	2.7	-3.5
Type 2 Diabetes (T2D) (2018)	1.5	2.7	5.7	-1.6	-2.4	-0.3
Lung FEV1/FVC ratio	1.2	5.9	11.4	-2.0	1.5	-3.4
Lung FVC	2.3	11.7	18.3	3.2	-2.6	4.3
Neuroticism	0.7	1.7	2.8	-0.0	1.7	-1.5
Chronotype (morning person)	0.3	0.6	1.3	-0.5	-1.2	0.6
Hair Pigment	0.0	0.4	0.6	0.6	-0.4	0.8
Tanning	0.0	0.2	0.7	-0.8	-0.1	-0.1
Hand grip strength (left)	1.4	3.7	6.4	2.1	0.6	2.5
Number of treatments/medications taken	3.0	5.4	11.4	-2.0	1.0	-3.4
Average weekly spirits intake	1.2	1.5	4.2	-0.3	-0.5	-2.0
Sensitivity / hurt feelings	0.9	1.6	3.6	-0.3	1.9	-1.1
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	0.4	0.7	0.2
Hearing difficulty/problems: Yes	1.1	1.7	3.2	-0.5	1.2	-1.8
Relative age of first facial hair	1.7	3.4	5.7	-0.2	2.4	-2.1
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	4.0	-0.5	2.0	-1.7
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	-0.0	0.5	-0.7
Ever had hysterectomy (womb removed)	1.1	1.3	2.0	-1.4	-0.7	-1.2
Systolic blood pressure, automated reading	1.6	4.6	9.4	-3.1	-0.8	-1.9
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.3	0.9	1.5	0.5
Angina	0.4	0.5	1.1	-0.3	0.6	-1.0
Medication for hormone replacement therapy	1.1	1.3	2.4	-0.8	-0.8	-1.5
Vitamin and mineral supplements	0.9	1.2	2.6	1.0	0.0	1.6
Supplements: Zinc	1.0	1.1	1.8	1.2	-0.0	1.3
Medication: Co-codamol	0.7	0.8	1.2	-0.8	0.7	-1.1
Medication: Metformin	3.3	4.6	6.9	-2.5	-2.6	-0.9
Diabetes (father)	0.4	0.5	1.4	-0.1	-0.1	1.2
Diabetes (mother)	1.3	1.6	3.1	-1.3	-0.1	-1.7
Severe depression (siblings)	0.2	0.2	0.4	0.4	0.2	-0.6
Pack years adult smoking proportion	0.2	0.4	1.0	-1.0	-0.2	-0.3
Impedance of leg (right)	0.2	1.1	3.0	0.3	-1.7	-0.2
Leg fat-free mass (left)	0.5	2.6	5.3	-1.3	2.3	-0.8
Trunk fat percentage	3.4	13.5	26.1	-5.1	-0.1	-3.8
Hand grip strength (right)	0.6	1.5	2.7	1.1	0.8	1.6
Townsend deprivation index at recruitment	0.9	1.2	1.8	1.0	-1.3	0.9
Current tobacco smoking	0.2	0.2	0.6	0.3	-0.7	-0.3
Average weekly fortified wine intake	0.3	0.4	1.0	-0.2	0.4	-1.0
Maternal smoking around birth	0.5	0.8	1.6	0.2	1.3	-0.8
Fed-up feelings	1.0	1.9	3.8	-1.9	0.3	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.5	0.0	1.2	-0.7
Relative age voice broke	0.9	1.4	2.5	-0.2	1.6	-1.3
Taking other prescription medications	3.2	4.9	7.7	-2.8	-0.2	-2.6
Age when periods started (menarche)	0.3	0.8	1.8	0.5	1.4	-0.5
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	3.4	-1.5	-1.4	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	2.5	1.5	0.9	1.6
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.7	-0.1	0.7	-1.6
Qualifications: CSEs or equivalent	0.2	0.2	0.5	-0.7	0.0	0.4
Serious illness, injury or assault to yourself	1.0	1.2	1.9	1.4	0.6	1.1
High blood pressure	1.8	4.9	8.1	-2.9	-0.7	-2.5
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.9	1.4	0.6	0.3
Multivitamins +/- minerals	0.4	0.5	1.0	-0.7	-1.0	-0.2
Stomach or abdominal pain in last month	0.2	0.2	0.7	-0.0	0.1	-0.9
Supplements: Glucosamine	0.6	0.8	1.8	-0.0	1.4	-0.8
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.0	0.6	-1.0	1.4
Medication: Atenolol	0.6	0.8	0.9	-0.9	-0.9	0.8
Medication: Levothyroxine sodium	0.2	0.4	0.8	-0.9	-0.3	-0.3
Sitting height	2.6	18.2	31.1	4.8	1.0	5.6
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	0.2	1.0	0.3
High blood pressure (mother)	0.3	0.5	0.7	0.2	0.8	-0.8
Body mass index (BMI)	2.7	11.3	21.0	-4.6	0.9	-3.5
Impedance of leg (left)	0.3	1.7	4.7	0.5	-2.2	0.2
Leg predicted mass (left)	0.5	2.6	5.6	-1.2	2.4	-0.7
Trunk fat mass	2.7	11.5	22.4	-4.7	0.6	-3.4
Waist circumference	2.1	7.8	15.9	-4.0	0.2	-2.7
Number of incorrect matches in round	0.8	1.3	1.7	-1.3	-1.3	-0.8
Past tobacco smoking	0.8	1.5	3.0	1.0	0.6	1.7
Alcohol usually taken with meals	0.5	0.9	2.4	0.3	-0.3	-1.6
Nervous feelings	0.1	0.2	0.6	-0.1	-0.8	-0.3
Frequency of tenseness / restlessness in last 2 weeks	2.8	4.3	7.6	-1.6	1.6	-2.8
Hearing difficulty/problems with background noise	0.3	0.4	0.9	-0.5	-0.4	-0.9
Hair/balding pattern: Pattern 2	0.6	0.8	1.8	-0.3	-0.8	1.3
Had menopause	0.5	0.6	1.0	-1.0	-0.5	-0.7
Had other major operations	0.5	0.6	1.1	-1.0	-0.3	-0.8
Forced vital capacity (FVC)	2.3	8.8	13.5	3.7	1.6	3.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.5	1.2	0.8	0.7
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	3.9	0.2	2.0	-1.3
Qualifications: None of the above	1.0	2.2	3.4	-1.9	-1.6	-0.8
Financial difficulties in last 2 years	1.1	1.5	2.0	-1.4	-0.7	-1.4
Mouth/teeth dental problems	0.1	0.2	0.3	0.6	-0.2	0.4
Heart attack	0.2	0.3	0.6	0.0	-0.6	-0.8
Allergy	1.3	3.0	5.2	-0.3	-2.3	1.9
Pain all over the body in last month	2.3	2.5	5.0	-1.5	0.2	-2.2
Diabetes (self-reported)	1.4	2.2	2.7	-1.6	-1.2	-1.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.0	-1.0	0.4	-0.8
Medication: Ramipril	2.4	3.1	7.1	-1.3	-2.7	0.8
Medication: Simvastatin	1.0	1.5	2.6	-1.2	-1.6	-0.7
Fluid intelligence score	0.2	0.5	0.9	0.9	0.5	-0.5
Illnesses of siblings	0.8	1.2	2.6	1.6	-0.5	0.8
Neuroticism score	0.6	1.3	2.7	-0.0	1.6	-1.1
Weight	1.3	6.2	10.9	-3.3	1.6	-2.3
Impedance of arm (right)	0.2	1.0	1.7	1.3	-1.0	0.7
Arm fat percentage (right)	3.3	13.1	24.3	-4.9	0.3	-3.9
Trunk fat-free mass	0.2	1.2	3.4	-0.4	1.8	-0.1
Hip circumference	1.1	4.9	10.6	-3.3	0.8	-1.8
Time employed in main current job	1.3	1.6	4.4	-0.2	-0.5	2.1
Alcohol intake versus 10 years previously	3.5	5.2	10.1	-3.2	-0.5	-2.3
Father’s age at death	0.5	0.7	1.0	1.0	-0.5	0.8
Worrier / anxious feelings	0.1	0.2	0.6	0.2	-0.8	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.5	0.1	1.2	-1.2
Falls in the last year	1.0	1.4	1.8	-1.3	0.8	-1.3
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	1.1	0.6	-0.1
Number of live births	0.5	0.7	1.3	0.9	1.1	-0.2
Forced expiratory volume in 1-second (FEV1)	2.8	9.5	13.8	3.7	1.9	3.3
Pulse rate	0.6	1.0	1.7	-1.0	-0.3	-1.3
Happiness	0.6	0.7	1.6	1.2	0.7	0.4
Noisy workplace	0.7	0.8	1.0	0.8	1.0	-0.9
Qualifications: A levels/AS levels or equivalent	1.6	3.6	5.8	2.2	0.4	2.4
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.0	3.8	1.9	0.6	1.4
Mouth/teeth dental problems: Dentures	2.2	3.7	6.2	-2.2	-0.4	-2.5
Asthma	1.9	3.8	8.0	-1.1	1.4	-2.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	-0.8	-0.0	-0.8
Medication: Cholesterol lowering	1.3	2.0	4.2	-1.1	-2.1	-0.8
Depression (self-reported)	0.6	0.7	1.7	0.1	0.7	-1.3
Medication: Lansoprazole	2.2	2.5	5.1	-0.7	1.4	-2.3
Prospective memory result	2.7	3.4	5.9	-2.4	0.3	-2.0
Lung cancer (father)	0.0	0.0	0.0	-0.0	-0.2	-0.1
Illnesses of mother	0.9	1.1	2.3	0.5	-1.5	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.5	7.8	2.8	1.5	2.5
Pulse wave Arterial Stiffness index	1.6	1.9	4.0	-1.0	0.8	-2.0
Impedance of arm (left)	0.4	1.8	2.7	1.6	-1.0	1.3
Arm fat mass (right)	2.7	11.3	21.2	-4.6	1.0	-3.4
Trunk predicted mass	0.2	1.2	3.5	-0.4	1.9	-0.1
Standing height	0.5	5.1	6.5	2.5	1.7	2.5
Length of working week for main job	2.8	3.1	4.9	-1.2	2.2	-1.7
Exposure to tobacco smoke at home	2.3	2.6	4.0	-0.3	2.0	-1.9
Breastfed as a baby	1.1	1.3	2.3	1.5	-0.1	1.3
Tense / ‘highly strung’	1.8	3.0	3.8	1.9	1.8	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.0	1.0	1.4	-0.7
Hair/balding pattern: Pattern 4	0.1	0.1	0.3	-0.3	-0.1	-0.5
Birth weight of first child	0.3	0.6	1.5	0.4	1.2	0.4
Peak expiratory flow (PEF)	0.6	1.5	2.1	1.4	1.1	1.1
Pulse wave reflection index	0.2	0.2	0.5	0.4	0.7	-0.2
Ever highly irritable/argumentative for 2 days	1.4	1.6	3.7	-0.1	1.9	-1.1
Loud music exposure frequency	0.1	0.1	0.2	-0.5	-0.2	-0.1
Qualifications: O levels/GCSEs or equivalent	3.6	5.7	8.4	2.9	1.8	2.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.5	0.2	0.3
Blood clot in the leg (DVT)	2.8	3.6	7.4	-0.0	2.7	-1.9
Medication: Paracetamol	0.0	0.1	0.1	0.3	0.2	-0.2
Headache pain in last month	0.2	0.3	0.9	-0.1	0.9	-0.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.2	1.5	0.8	1.5
Glaucoma (self-reported)	0.3	0.4	1.0	0.1	0.3	1.0
Gout (self-reported)	1.9	2.5	5.6	-2.4	-0.9	-1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	-0.9	0.6	-0.2
Medication: Amlodipine	0.9	1.3	2.1	-1.0	-0.9	-1.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.9	-1.0	0.3	-1.7
Birth weight	0.6	1.3	2.2	-1.0	1.5	-0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.7	-0.8	0.8	-0.7
High blood pressure (siblings)	0.2	0.3	0.8	-0.9	0.0	-0.1
Forced vital capacity (FVC), Best measure	2.0	7.2	11.0	3.3	1.6	2.9
Body fat percentage	4.3	17.1	32.2	-5.7	-0.2	-4.4
Leg fat percentage (right)	5.5	19.9	35.8	-6.0	-0.1	-4.9
Arm fat-free mass (right)	0.3	1.6	3.0	-1.3	1.7	-0.5
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.2	0.5	0.0
Comparative body size at age 10	0.8	2.3	6.2	-2.5	-0.6	0.5
Number of full brothers	1.3	1.6	3.0	1.7	0.3	1.3
Worry too long after embarrassment	1.1	1.8	4.0	1.1	-0.3	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	4.3	-0.2	0.4	-2.1
Wheeze or whistling in the chest in last year	2.9	5.2	10.9	-1.1	1.8	-3.3
Number of children fathered	1.0	1.1	2.7	-0.8	-0.4	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	2.4	-1.5	-0.5	-1.6
Age at first live birth	3.1	5.5	10.8	3.3	-0.5	2.3
Pulse wave peak to peak time	2.2	2.6	5.8	1.2	-0.7	2.4
Health satisfaction	3.5	4.6	6.9	-0.2	2.6	-2.6
Shortness of breath walking on level ground	3.2	3.9	6.9	-1.4	1.7	-2.6
Qualifications: College or University degree	0.2	0.6	1.2	1.1	-0.1	0.8
Eye problems/disorders: None of the above	1.7	2.0	3.4	-1.3	-1.8	-1.0
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.1	1.1	0.7	-0.0
Emphysema/chronic bronchitis	0.3	0.4	0.7	-0.8	0.3	-0.6
Medication for pain relief, constipation, heartburn	1.0	1.7	3.3	1.3	-0.1	1.8
Neck or shoulder pain in last month	3.1	4.3	7.4	-0.8	2.2	-2.7
Medication: Blood pressure	1.1	1.9	2.7	-1.6	-1.2	-1.2
Angina (self-reported)	0.2	0.3	0.6	-0.2	0.4	-0.8
Migraine (self-reported)	1.5	1.8	4.1	2.0	1.0	0.5
Medication: Ibuprofen	0.3	0.4	0.6	-0.4	0.8	-0.6
Medication: Allopurinol	2.2	3.0	6.1	-2.5	-0.5	-1.6
Medication: Omeprazole	1.0	1.2	2.0	-1.4	0.5	-1.2
Medication: Seretide 50 evohaler	1.6	1.8	3.3	-1.4	0.5	-1.8
Mean time to correctly identify matches	0.6	1.2	2.5	-1.1	-1.6	-0.2
Heart disease (mother)	0.7	0.9	1.6	-1.3	-0.4	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.6	4.3	7.1	2.4	-0.4	2.7
Whole body fat mass	3.1	12.9	23.1	-4.8	1.0	-3.8
Leg fat mass (right)	3.8	14.7	25.7	-5.1	0.9	-4.2
Arm predicted mass (right)	0.3	1.7	3.5	-1.1	1.9	-0.5
Pulse rate, automated reading	0.7	2.1	4.7	0.1	1.3	-2.2
Alcohol intake frequency.	0.2	0.5	0.8	-0.9	0.2	-0.9
Comparative height size at age 10	0.1	0.7	1.3	-0.4	1.1	-0.8
Number of full sisters	0.0	0.0	0.1	-0.3	-0.1	-0.2
Suffer from ‘nerves’	0.2	0.4	0.7	0.8	-0.1	-0.6
Overall health rating	1.5	3.2	8.0	-1.0	0.7	-2.8
Chest pain or discomfort	0.9	1.3	2.2	0.8	1.5	-1.1
Had major operations	2.6	3.0	4.9	-2.2	-1.4	-1.5
Age at last live birth	1.0	1.5	3.3	1.8	-0.3	1.0
Family relationship satisfaction	0.1	0.1	0.3	0.3	0.1	0.5
Leg pain on walking	3.1	3.8	5.8	-0.9	2.2	-2.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.0	0.0	0.9	-1.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.1	-0.6	1.1	-1.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.7	-1.3	-0.9	-0.7
Medication: Aspirin	0.7	0.9	1.8	-0.7	-1.3	-0.7
Supplements: Vitamin C	0.5	0.6	0.9	-0.6	0.8	-1.0
Knee pain experienced in last month	5.6	8.7	20.5	0.8	4.5	-2.2
Hypertension (Self-reported)	1.9	5.3	9.4	-3.1	-0.7	-2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	0.8	0.1	0.4
Illnesses of father: Heart disease	1.6	2.2	3.7	-1.6	0.6	-1.9
Illnesses of siblings: Diabetes	0.8	1.0	2.3	-1.5	0.7	-0.3
Smoking status: Previous	0.6	0.8	2.1	-0.6	0.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	0.4	0.7	0.9
Whole body fat-free mass	0.3	1.7	4.0	-0.9	2.0	-0.4
Leg fat-free mass (right)	0.3	1.7	4.5	-0.8	2.1	-0.2
Arm fat percentage (left)	3.0	11.9	22.8	-4.8	0.2	-3.6
Average weekly red wine intake	1.3	1.9	5.0	2.2	0.2	0.8
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	-0.8	-0.1	-0.3
Mood swings	0.8	1.4	2.6	-0.5	1.2	-1.6
Loneliness, isolation	0.8	1.1	1.9	-0.3	1.4	-1.1
Long-standing illness, disability or infirmity	0.8	1.2	2.8	0.1	0.9	-1.7
Ever had bowel cancer screening	0.8	1.0	3.0	-0.2	0.0	-1.7
Diabetes diagnosed by doctor	1.6	2.6	4.4	-1.5	-2.1	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.6	-0.7	-0.6	-0.7
Friendships satisfaction	0.1	0.1	0.2	0.2	0.4	0.4
Qualifications: nursing, teaching	2.6	4.0	6.9	2.6	1.2	1.9
Commuting to job workplace: Walk	0.5	0.5	1.1	-0.7	-1.0	-0.1
Eye problems/disorders: Cataract	0.5	0.6	1.3	0.5	1.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.7	0.1	0.1	0.8
Medication for cholesterol	1.9	2.9	5.4	1.8	0.2	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	3.1	1.4	1.8	0.3
Back pain experienced in last month	0.8	1.2	2.4	0.3	1.6	-1.0
Mineral and other dietary supplements	1.3	1.7	2.9	0.5	-1.4	1.7
Breast cancer (self-reported)	0.2	0.3	0.7	-0.8	0.1	-0.4
Asthma (self-reported)	1.8	3.6	7.5	-1.1	1.5	-2.7
Osteoporosis (self-reported)	1.6	1.9	4.0	0.5	2.0	-1.2
Osteoarthritis (self-reported)	1.9	2.5	4.6	-0.6	2.1	-1.6
Medication: Aspirin	0.4	0.6	1.3	-0.4	-1.2	-0.5
Medication: Gliclazide	2.7	3.1	4.4	-2.1	-0.8	-2.1
Illnesses of father: None of the above (group 1)	3.6	4.5	9.9	3.2	1.3	1.3
Smoking status: Current	0.4	0.6	1.5	0.2	-1.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	3.1	1.8	0.6	1.5
Whole body water mass	0.3	1.7	4.2	-0.9	2.0	-0.3
Leg predicted mass (right)	0.3	1.8	4.8	-0.8	2.2	-0.2
Arm fat mass (left)	2.5	10.2	19.6	-4.4	1.0	-3.2
Number of self-reported non-cancer illnesses	4.6	8.0	13.5	-3.1	0.8	-3.7
Average weekly champagne plus white wine intake	0.0	0.0	0.0	0.0	0.1	0.1
Miserableness	0.1	0.2	0.5	-0.7	-0.2	-0.3
Guilty feelings	1.1	1.7	4.2	0.9	2.0	-0.1
Wears glasses or contact lenses	0.1	0.1	0.2	-0.2	0.4	0.0
Ever taken oral contraceptive pill	1.1	1.2	2.1	1.0	0.7	-1.5
Hearing aid user	0.6	0.7	1.2	-1.1	-0.8	-0.5
Mother’s age at death	0.2	0.2	0.3	-0.4	0.6	0.3
Financial situation satisfaction	0.2	0.3	0.3	-0.5	-0.5	-0.5
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.4	1.5	0.7	0.9
Commuting to job workplace: Public transport	0.9	1.1	2.8	1.7	-0.5	0.6
Eye problems/disorders: Glaucoma	1.2	1.4	3.1	1.0	0.0	1.8
Medication: Blood pressure	0.5	0.9	1.7	-1.0	-0.0	-1.3
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.0	-1.0	0.8	-0.9
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.3	0.1	1.0	-1.1
High cholesterol (Self-reported)	1.1	2.0	4.2	-1.2	-2.1	-0.2
Medication: Bendroflumethiazide	1.4	2.2	4.1	-2.0	-1.3	-0.8
Medication: Paracetamol	0.2	0.3	0.4	0.4	0.6	-0.6
Medication: Lisinopril	1.2	1.5	2.5	-1.6	0.4	-1.4
Medication: Atorvastatin	0.9	1.2	2.0	-1.0	-1.4	-0.7
Illnesses of father: High blood pressure	0.9	1.1	2.1	-1.1	-1.5	-0.2
Alcohol drinker status: Never	0.3	0.3	0.8	0.0	-0.9	0.4
Ever smoked	0.4	0.7	1.2	-0.1	-0.9	-1.1
Basal metabolic rate	0.4	2.3	3.5	-1.6	1.9	-0.9
Leg fat percentage (left)	5.4	19.4	37.1	-6.1	-0.6	-4.5
Arm fat-free mass (left)	0.5	2.7	3.9	-2.0	1.7	-1.1
Number of operations (self-reported)	1.5	2.3	4.7	-1.0	1.0	-2.2
Average weekly beer plus cider intake	0.8	1.2	3.2	-0.1	-1.8	0.6
Irritability	1.5	2.5	4.0	-0.3	2.0	-1.8
Risk taking	1.3	1.9	4.1	-1.2	-0.4	-2.0
Ever had prostate specific antigen (PSA) test	2.4	2.8	5.9	-0.0	2.4	-1.6
Fractured/broken bones in last 5 years	0.2	0.2	0.7	0.8	0.1	0.2
Age started oral contraceptive pill	4.3	5.4	6.1	-2.5	-2.2	-2.3
Diastolic blood pressure, automated reading	1.2	3.6	6.6	-2.6	-0.2	-2.0
Ever depressed for a whole week	0.6	0.7	1.3	1.1	0.9	0.4
Unable to work because of sickness or disability	1.5	1.9	4.4	-1.0	0.7	-2.1
Commuting to job workplace: Cycle	0.4	0.5	1.0	-1.0	-0.3	0.7
Myopia	0.6	0.9	2.0	0.4	-1.4	-0.8
Vascular/heart problems diagnosed by doctor	2.1	5.6	8.9	3.0	0.9	2.7
Cholesterol lowering medication	1.1	1.5	2.3	-1.2	-0.9	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.2	-1.1	0.0	-1.0
Pain experienced in last month	2.0	3.4	5.0	0.5	-2.2	2.2
Supplements: Calcium	1.3	1.5	2.4	1.6	1.4	-0.0
Basal cell carcinoma (self-reported)	1.0	1.2	3.2	0.6	1.8	0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	-0.0	-1.0	-0.5
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	4.9	-0.3	2.2	-1.9
Heart disease (siblings)	0.1	0.1	0.4	-0.6	0.1	-0.1
Alcohol drinker status: Previous	1.9	2.1	3.8	-0.6	1.5	-1.9
Pack years of smoking	0.5	0.8	1.6	-1.3	-0.3	-0.8
Impedance of whole body	0.3	1.7	2.8	1.2	-1.7	0.8
Leg fat mass (left)	3.6	14.1	26.0	-5.1	0.7	-4.0
Arm predicted mass (left)	0.5	2.5	3.9	-2.0	1.5	-1.1