Hub : Genes

RP11-65J21.3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.167 0.045 1.8e-05 0.122 NA 0.101 NA 0.111 2.0e-09 NA 5.4e-08 NA 1.1e-08
2 GTEx Thyroid 0.352 0.055 1.1e-10 0.319 NA 0.294 NA 0.312 5.7e-25 NA 8.2e-23 NA 2.6e-24

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.7 1.1 1.6 -0.8 1.3
Bipolar Disorder or Schizophrenia 1.2 3.0 4.9 -2.2 -1.0
Depressed Affect (Nagel 2018) 1.1 2.4 2.4 1.5 1.5
Depression (Nagel 2018) 0.1 0.2 0.2 0.5 0.4
Intelligence (Savage-Jansen 2018) 0.7 2.2 4.2 -0.5 2.0
Neuroticism (Nagel 2018) 0.2 0.4 0.7 0.8 0.4
Schizophrenia (2018) 2.4 5.1 5.5 -2.2 -2.3
Schizophrenia vs Biploar Disorder 3.0 4.0 7.8 0.4 -2.8
Worry (Nagel 2018) 0.2 0.4 0.8 -0.9 -0.2
Alzheimer’s Disease (in mother) 1.1 1.3 2.7 -1.6 -0.1
Alzheimer’s Disease (in father) 0.3 0.3 0.3 0.6 0.5
Alzheimer’s Disease (including proxy) 1.0 1.4 2.2 -1.5 0.8
Crohns Disease (2017) 0.6 1.4 1.7 -1.3 -1.1
Irritable Bowel Disease (IBD) 1.8 4.2 5.8 -2.4 -1.6
Ulcerative Colitis (UC) 1.3 2.4 3.3 -1.8 -1.2
Major Depression (MDD) 2.3 2.7 5.4 -0.3 2.3
Reaction Time 1.1 2.0 3.5 -0.8 1.9
Verbal and Numeric Reasoning (VNR) 0.6 1.3 2.4 0.6 1.5
Breast Cancer 0.1 0.3 0.4 0.6 0.5
Ovarian Cancer 0.0 0.0 0.0 0.2 -0.2
Prostate Cancer 0.4 0.6 0.9 -0.6 -1.0
Age at First Birth 0.2 0.2 0.2 0.5 -0.5
Bipolar Disorder (2011) 0.1 0.1 0.1 -0.3 0.0
Body Mass Index (BMI) (2010) 0.4 0.5 1.0 1.0 0.2
Coronary Artery Disease (CAD) 2.0 2.4 4.5 -0.5 2.1
Crohns Disease (2012) 0.9 1.5 2.7 -1.7 -0.5
Mean Putamen Volume 0.6 0.7 1.3 1.1 -0.2
Fasting Glucose 0.2 0.2 0.4 0.1 0.6
HbA1C 1.6 1.8 2.9 0.8 -1.7
HDL Cholesterol 0.4 0.7 1.4 -0.2 -1.2
LDL Cholesterol 0.2 0.3 0.4 -0.6 0.3
Lupus 2.8 4.2 8.0 0.6 -2.8
Neuroticism (2016) 0.1 0.1 0.1 0.3 0.2
Primary Biliary Cirrhosis 0.6 0.8 1.6 -0.2 1.3
Rheumatoid Arthritis 0.0 0.0 0.0 -0.0 -0.2
Schizophrenia (2014) 2.4 5.3 7.4 -1.8 -2.7
Triglycerides 0.7 1.2 2.5 0.0 1.6
Type 2 Diabetes (T2D) (2012) 0.6 0.7 0.9 -0.9 -0.8
Ulcerative Colitis 1.1 1.6 2.5 -0.9 -1.6
Blood Eosinophil Count 0.0 0.2 0.5 0.7 0.1
Blood Platelet Count 0.2 2.5 4.2 0.9 2.1
Blood Red Count 0.7 7.1 12.9 3.6 -1.2
Blood White Count 0.4 3.0 6.0 -0.3 2.5
Heel T-Score 0.6 5.1 9.5 -0.8 -3.1
BMI 0.6 3.6 3.8 2.0 1.8
Height 4.7 90.5 176.9 2.0 -13.3
Waist Hip Ratio (WHR) 0.5 2.3 4.5 -0.3 -2.1
Systolic Blood Pressure 1.7 8.5 11.6 2.4 3.4
Smoking Status 0.6 1.5 2.6 -1.6 -0.6
Allergy or Eczema 0.3 0.8 1.3 0.6 -1.1
Cardiovascular Disease 1.2 4.0 7.7 2.8 0.5
Hypothyroidism (self reported) 0.8 1.9 3.3 0.7 1.8
Respiratory disease 0.6 1.4 2.5 1.6 -0.5
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.1 -0.2 0.0
Lung FEV1/FVC ratio 0.4 1.8 2.0 1.4 -1.3
Lung FVC 0.8 4.2 6.2 -1.5 -2.5
Neuroticism 0.1 0.3 0.6 -0.8 0.2
Chronotype (morning person) 0.0 0.1 0.1 -0.2 -0.2
Hair Pigment 0.0 0.3 0.4 -0.6 -0.4
Tanning 0.0 0.4 0.7 0.9 0.2
Hand grip strength (left) 2.2 5.7 9.4 1.4 -3.1
Number of treatments/medications taken 0.1 0.2 0.3 0.6 -0.1
Average weekly spirits intake 2.4 3.0 4.5 2.1 1.3
Sensitivity / hurt feelings 0.5 0.9 1.6 0.5 -1.3
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.3 0.6 -0.2
Hearing difficulty/problems: Yes 0.6 1.0 1.5 0.7 1.2
Relative age of first facial hair 14.3 29.4 55.5 -1.8 -7.5
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.3 0.6 -0.2
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.1 -0.4 -0.2
Ever had hysterectomy (womb removed) 1.5 1.7 3.3 1.8 0.2
Systolic blood pressure, automated reading 2.8 8.2 12.5 2.0 3.5
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.1 -0.3 0.3
Angina 0.5 0.7 1.3 -0.3 1.1
Medication for hormone replacement therapy 0.6 0.7 1.2 -1.1 0.5
Vitamin and mineral supplements 0.2 0.3 0.4 -0.6 0.4
Supplements: Zinc 0.9 1.0 1.3 1.1 0.8
Medication: Co-codamol 0.8 1.0 2.0 -0.1 1.4
Medication: Metformin 0.3 0.5 1.0 0.0 1.0
Diabetes (father) 0.1 0.1 0.2 0.2 -0.4
Diabetes (mother) 2.0 2.5 2.6 1.6 -1.6
Severe depression (siblings) 1.4 1.6 1.7 -1.3 -1.2
Pack years adult smoking proportion 0.7 1.1 2.2 0.2 1.5
Impedance of leg (right) 0.7 3.2 6.3 -2.5 -0.0
Leg fat-free mass (left) 2.3 12.0 13.5 3.2 -3.7
Trunk fat percentage 0.3 1.1 2.0 0.5 1.4
Hand grip strength (right) 2.1 5.6 10.9 0.6 -3.3
Townsend deprivation index at recruitment 2.5 3.6 5.7 -2.4 1.2
Current tobacco smoking 1.1 1.8 2.2 -1.5 1.2
Average weekly fortified wine intake 1.1 1.2 2.5 0.1 1.6
Maternal smoking around birth 0.0 0.0 0.0 0.2 0.2
Fed-up feelings 0.3 0.6 1.1 1.0 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.1 -0.4 0.4
Relative age voice broke 10.1 15.4 29.6 -1.1 -5.4
Taking other prescription medications 0.0 0.0 0.0 0.0 -0.0
Age when periods started (menarche) 9.6 23.1 31.6 -3.8 -5.6
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.6 0.8 0.5
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.6 5.1 -2.3 -2.0
Tinnitus: Yes, but not now, but have in the past 1.7 1.9 3.4 -1.8 0.6
Qualifications: CSEs or equivalent 0.5 0.6 1.1 0.5 -1.0
Serious illness, injury or assault to yourself 0.0 0.0 0.0 0.2 -0.0
High blood pressure 1.7 4.9 8.9 3.0 0.9
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.2 0.4 -0.4
Multivitamins +/- minerals 0.7 0.9 1.2 1.1 -0.7
Stomach or abdominal pain in last month 0.4 0.6 0.8 -0.9 0.6
Supplements: Glucosamine 0.2 0.3 0.4 -0.3 0.6
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.4 -0.7 0.1
Medication: Atenolol 1.2 1.5 1.6 1.3 1.2
Medication: Levothyroxine sodium 0.6 1.0 1.3 -0.8 1.1
Sitting height 2.3 16.6 20.8 3.5 -4.6
Chronic bronchitis/emphysema (father) 0.8 1.0 1.2 -1.1 0.9
High blood pressure (mother) 4.5 6.3 6.5 2.5 2.5
Body mass index (BMI) 0.6 2.4 3.9 2.0 1.0
Impedance of leg (left) 0.7 3.5 7.0 -2.6 -0.2
Leg predicted mass (left) 2.2 11.7 13.3 3.2 -3.6
Trunk fat mass 0.2 1.0 1.8 1.3 -0.4
Waist circumference 0.2 0.9 0.9 1.0 -0.9
Number of incorrect matches in round 0.6 0.9 0.9 1.0 1.0
Past tobacco smoking 0.2 0.4 0.8 0.2 0.9
Alcohol usually taken with meals 0.3 0.5 0.7 -0.8 0.6
Nervous feelings 0.0 0.1 0.1 -0.3 -0.0
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 2.6 -1.6 0.0
Hearing difficulty/problems with background noise 0.1 0.1 0.1 -0.2 0.4
Hair/balding pattern: Pattern 2 4.2 5.3 10.3 -0.5 -3.2
Had menopause 2.0 2.5 2.7 1.6 1.5
Had other major operations 0.6 0.8 1.2 1.1 -0.5
Forced vital capacity (FVC) 4.0 15.5 31.0 0.2 -5.6
Heel bone mineral density (BMD) T-score, automated (right) 2.0 4.6 6.0 -1.8 -2.4
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 2.0 -1.4 1.1
Qualifications: None of the above 0.5 1.1 2.1 -0.2 1.4
Financial difficulties in last 2 years 0.8 1.0 2.0 -0.1 1.4
Mouth/teeth dental problems 0.0 0.0 0.0 -0.0 -0.0
Heart attack 0.2 0.2 0.4 -0.1 0.6
Allergy 0.0 0.1 0.1 -0.4 0.1
Pain all over the body in last month 1.5 1.6 3.2 -0.0 -1.8
Diabetes (self-reported) 0.1 0.2 0.3 0.2 0.6
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.5 -0.3 -0.7
Medication: Ramipril 3.3 4.2 7.7 -0.9 2.8
Medication: Simvastatin 5.6 8.3 8.3 2.9 2.9
Fluid intelligence score 1.4 3.0 5.8 0.5 2.4
Illnesses of siblings 0.9 1.2 2.4 -1.6 -0.1
Neuroticism score 0.1 0.1 0.2 -0.4 -0.2
Weight 1.3 6.5 6.6 2.5 -2.6
Impedance of arm (right) 1.4 6.4 9.6 -3.1 1.8
Arm fat percentage (right) 0.6 2.5 4.5 0.8 2.1
Trunk fat-free mass 4.1 23.7 35.0 3.5 -5.9
Hip circumference 0.4 1.6 3.1 1.8 -0.2
Time employed in main current job 0.5 0.5 0.6 -0.7 -0.7
Alcohol intake versus 10 years previously 0.4 0.6 0.7 0.9 -0.8
Father’s age at death 0.1 0.1 0.1 -0.3 -0.2
Worrier / anxious feelings 0.3 0.7 1.3 -0.1 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.7 -0.8 0.1
Falls in the last year 0.5 0.7 1.2 -1.1 -0.4
Hair/balding pattern: Pattern 3 1.8 2.6 5.0 0.5 2.2
Number of live births 0.3 0.4 0.6 0.3 -0.8
Forced expiratory volume in 1-second (FEV1) 4.8 16.0 31.7 0.6 -5.6
Pulse rate 0.8 1.4 2.6 -0.4 -1.6
Happiness 1.7 2.1 3.9 0.6 2.0
Noisy workplace 0.0 0.0 0.1 -0.1 0.2
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.7 0.8 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.6 0.1 -0.8
Mouth/teeth dental problems: Dentures 1.0 1.7 2.0 1.2 1.4
Asthma 0.6 1.1 2.2 1.5 0.2
Medication: Ibuprofen (e.g. Nurofen) 2.2 2.8 5.5 -0.1 -2.4
Medication: Cholesterol lowering 2.2 3.4 3.5 1.9 1.9
Depression (self-reported) 0.5 0.6 0.7 0.8 -0.7
Medication: Lansoprazole 0.2 0.2 0.3 -0.5 0.4
Prospective memory result 0.5 0.7 1.3 0.3 -1.1
Lung cancer (father) 0.9 1.1 1.5 1.2 -0.8
Illnesses of mother 1.5 1.9 3.6 -0.4 -1.9
Forced expiratory volume in 1-second (FEV1), Best measure 3.3 10.6 21.3 -0.0 -4.6
Pulse wave Arterial Stiffness index 0.3 0.3 0.5 0.4 -0.7
Impedance of arm (left) 1.1 4.9 7.1 -2.7 1.6
Arm fat mass (right) 0.4 1.6 3.3 1.8 0.1
Trunk predicted mass 4.2 23.7 35.2 3.5 -5.9
Standing height 3.5 35.2 66.7 1.9 -8.2
Length of working week for main job 0.3 0.4 0.7 0.8 0.3
Exposure to tobacco smoke at home 2.0 2.2 2.3 1.5 1.4
Breastfed as a baby 2.4 2.9 4.0 -2.0 -1.4
Tense / ‘highly strung’ 0.3 0.5 0.9 -0.9 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 1.5 -0.7 1.2
Hair/balding pattern: Pattern 4 2.5 6.0 12.0 0.1 3.5
Birth weight of first child 2.9 5.3 7.3 -1.8 -2.7
Peak expiratory flow (PEF) 13.2 30.6 59.3 1.4 -7.7
Pulse wave reflection index 0.3 0.4 0.7 0.0 0.8
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.2 -1.1 -0.3
Loud music exposure frequency 1.8 2.0 2.1 -1.5 1.3
Qualifications: O levels/GCSEs or equivalent 2.8 4.4 7.9 2.8 -1.0
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.0 0.0 0.1
Blood clot in the leg (DVT) 0.1 0.2 0.3 0.1 -0.6
Medication: Paracetamol 0.0 0.1 0.1 -0.2 -0.3
Headache pain in last month 0.3 0.5 0.9 0.4 1.0
Medication for cholesterol, blood pressure or diabetes 1.8 2.9 4.6 -2.1 -1.1
Glaucoma (self-reported) 1.8 2.1 2.5 -1.3 -1.6
Gout (self-reported) 1.4 2.0 2.6 1.6 1.2
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 3.0 0.9 1.7
Medication: Amlodipine 6.4 8.9 11.3 2.6 3.4
Medication: Ventolin 100micrograms inhaler 2.2 2.8 4.5 2.1 -1.0
Birth weight 0.2 0.5 0.9 -1.0 -0.1
Chronic bronchitis/emphysema (mother) 1.1 1.2 1.8 -1.3 0.8
High blood pressure (siblings) 1.5 2.1 3.4 1.8 -0.9
Forced vital capacity (FVC), Best measure 3.9 14.2 28.4 -0.2 -5.3
Body fat percentage 0.4 1.5 2.8 0.4 1.7
Leg fat percentage (right) 0.4 1.6 2.8 0.6 1.7
Arm fat-free mass (right) 4.0 20.4 29.3 3.4 -5.4
Exposure to tobacco smoke outside home 4.9 6.5 6.5 2.6 2.6
Comparative body size at age 10 0.4 1.1 2.2 -0.1 -1.5
Number of full brothers 1.8 2.2 3.2 1.8 1.1
Worry too long after embarrassment 0.2 0.3 0.5 0.7 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 3.5 -1.9 -0.1
Wheeze or whistling in the chest in last year 0.1 0.2 0.2 0.5 0.5
Number of children fathered 0.3 0.3 0.6 0.7 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 3.2 -1.8 -0.1
Age at first live birth 0.1 0.1 0.2 0.3 -0.4
Pulse wave peak to peak time 0.0 0.0 0.1 -0.3 0.2
Health satisfaction 0.2 0.2 0.3 0.4 -0.5
Shortness of breath walking on level ground 0.3 0.4 0.7 0.8 0.3
Qualifications: College or University degree 0.4 1.4 1.5 -1.1 1.2
Eye problems/disorders: None of the above 0.4 0.4 0.8 -0.9 -0.1
Mouth/teeth dental problems: Loose teeth 1.0 1.2 1.5 1.2 1.0
Emphysema/chronic bronchitis 1.2 1.4 1.7 -1.3 -1.0
Medication for pain relief, constipation, heartburn 0.4 0.7 1.3 -0.1 1.1
Neck or shoulder pain in last month 0.7 1.0 1.0 1.0 -1.0
Medication: Blood pressure 1.2 2.1 2.8 1.7 1.2
Angina (self-reported) 0.6 0.8 1.4 -0.5 1.2
Migraine (self-reported) 0.1 0.1 0.2 0.4 -0.3
Medication: Ibuprofen 2.2 2.6 4.0 -1.1 -2.0
Medication: Allopurinol 2.7 3.6 7.1 0.1 2.7
Medication: Omeprazole 0.1 0.1 0.2 -0.1 -0.5
Medication: Seretide 50 evohaler 0.9 1.1 2.2 0.1 1.5
Mean time to correctly identify matches 2.1 3.9 6.2 -1.3 2.5
Heart disease (mother) 0.7 0.8 1.4 1.2 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.1 1.8 -1.3 -0.7
Whole body fat mass 0.2 0.9 1.8 1.4 -0.3
Leg fat mass (right) 0.4 1.4 2.8 1.7 -0.2
Arm predicted mass (right) 4.0 20.6 29.5 3.4 -5.4
Pulse rate, automated reading 0.2 0.7 1.1 0.6 -1.0
Alcohol intake frequency. 0.2 0.4 0.6 0.4 0.8
Comparative height size at age 10 1.3 7.4 7.5 2.7 -2.7
Number of full sisters 2.6 3.1 6.2 0.3 2.5
Suffer from ‘nerves’ 1.0 1.6 3.2 -1.8 -0.2
Overall health rating 0.0 0.0 0.1 0.0 -0.3
Chest pain or discomfort 0.2 0.3 0.4 0.3 -0.7
Had major operations 0.5 0.6 1.0 0.5 -1.0
Age at last live birth 0.1 0.1 0.1 -0.3 -0.4
Family relationship satisfaction 0.6 0.8 1.3 -0.5 1.1
Leg pain on walking 0.2 0.3 0.6 -0.8 0.0
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 1.5 -0.0 1.2
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.5 1.2 -0.4
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.9 -0.9 -0.3
Medication: Aspirin 0.8 1.1 1.3 0.9 1.1
Supplements: Vitamin C 1.5 1.7 1.8 1.3 1.3
Knee pain experienced in last month 0.1 0.2 0.2 -0.4 -0.4
Hypertension (Self-reported) 1.6 4.5 8.0 2.8 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.4 -0.6 0.0
Illnesses of father: Heart disease 0.2 0.2 0.4 0.0 0.7
Illnesses of siblings: Diabetes 0.6 0.7 1.3 0.3 1.1
Smoking status: Previous 0.9 1.3 2.5 -0.2 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 2.8 5.9 11.4 0.5 -3.4
Whole body fat-free mass 3.4 19.6 27.2 3.5 -5.2
Leg fat-free mass (right) 2.1 11.5 13.4 3.1 -3.7
Arm fat percentage (left) 0.6 2.4 3.8 1.0 2.0
Average weekly red wine intake 0.1 0.1 0.2 -0.5 -0.2
Handedness (chirality/laterality): Left-handed 1.8 2.1 2.5 -1.3 1.6
Mood swings 1.5 2.8 3.8 1.3 2.0
Loneliness, isolation 0.4 0.6 0.6 0.8 0.8
Long-standing illness, disability or infirmity 0.4 0.6 0.7 -0.8 0.7
Ever had bowel cancer screening 0.7 0.8 1.6 -0.0 1.3
Diabetes diagnosed by doctor 0.0 0.0 0.0 0.1 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.1 3.7 0.7 -1.9
Friendships satisfaction 7.8 9.7 17.5 -1.4 4.2
Qualifications: nursing, teaching 0.9 1.4 1.9 1.4 -0.9
Commuting to job workplace: Walk 1.9 2.1 2.6 -1.2 1.6
Eye problems/disorders: Cataract 1.1 1.3 2.5 1.6 0.3
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 2.3 -1.1 -1.5
Medication for cholesterol 0.3 0.4 0.8 -0.2 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.0 0.0 -0.2 0.1
Back pain experienced in last month 0.1 0.2 0.2 0.3 0.5
Mineral and other dietary supplements 0.2 0.2 0.4 0.3 -0.6
Breast cancer (self-reported) 0.2 0.2 0.4 0.6 -0.0
Asthma (self-reported) 0.3 0.5 1.0 1.0 0.2
Osteoporosis (self-reported) 0.4 0.6 0.6 0.8 0.7
Osteoarthritis (self-reported) 1.6 2.1 4.0 -2.0 0.5
Medication: Aspirin 1.1 1.5 2.7 0.5 1.6
Medication: Gliclazide 1.7 1.9 3.0 0.9 1.7
Illnesses of father: None of the above (group 1) 1.3 1.6 2.3 -1.0 -1.5
Smoking status: Current 0.7 1.2 1.5 -1.2 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 4.0 7.8 0.5 -2.8
Whole body water mass 3.3 18.9 26.2 3.4 -5.1
Leg predicted mass (right) 2.1 11.4 13.1 3.1 -3.6
Arm fat mass (left) 0.6 2.3 4.6 2.1 -0.0
Number of self-reported non-cancer illnesses 0.6 1.0 1.9 0.2 1.4
Average weekly champagne plus white wine intake 0.3 0.3 0.7 -0.1 0.8
Miserableness 0.1 0.2 0.3 0.5 0.4
Guilty feelings 0.6 0.8 1.3 1.1 -0.6
Wears glasses or contact lenses 1.7 2.0 3.8 0.3 2.0
Ever taken oral contraceptive pill 2.2 2.5 3.0 -1.4 -1.7
Hearing aid user 0.1 0.1 0.1 0.3 -0.1
Mother’s age at death 0.5 0.6 0.6 0.8 0.7
Financial situation satisfaction 1.6 2.0 2.4 1.3 1.6
Tinnitus: Yes, now most or all of the time 2.2 2.5 5.0 -2.2 0.2
Commuting to job workplace: Public transport 1.1 1.4 2.7 -0.2 1.6
Eye problems/disorders: Glaucoma 1.1 1.3 2.6 -0.2 -1.6
Medication: Blood pressure 0.8 1.6 1.6 1.2 1.3
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.5 0.7 -0.6
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.6 -0.3 1.3
High cholesterol (Self-reported) 2.9 5.2 8.7 1.3 3.0
Medication: Bendroflumethiazide 1.3 1.9 2.2 1.5 1.3
Medication: Paracetamol 0.7 1.1 2.1 -1.4 -0.2
Medication: Lisinopril 0.0 0.0 0.1 0.0 -0.2
Medication: Atorvastatin 0.6 0.8 1.4 -0.5 1.2
Illnesses of father: High blood pressure 0.2 0.3 0.5 0.7 0.3
Alcohol drinker status: Never 1.0 1.2 1.8 0.8 1.4
Ever smoked 0.3 0.5 0.8 -0.9 -0.5
Basal metabolic rate 2.8 15.5 20.3 3.3 -4.5
Leg fat percentage (left) 0.4 1.4 2.4 0.6 1.6
Arm fat-free mass (left) 3.4 17.1 23.9 3.2 -4.9
Number of operations (self-reported) 0.2 0.2 0.5 0.7 0.0
Average weekly beer plus cider intake 1.2 1.8 3.5 0.0 -1.9
Irritability 0.3 0.5 0.9 -0.3 -1.0
Risk taking 1.7 2.5 4.2 -2.0 -0.9
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.2 -1.1 -0.5
Fractured/broken bones in last 5 years 0.9 1.1 1.6 -1.2 -0.8
Age started oral contraceptive pill 0.0 0.0 0.0 0.2 -0.2
Diastolic blood pressure, automated reading 1.5 4.5 6.4 2.5 -1.6
Ever depressed for a whole week 1.9 2.3 2.7 -1.4 1.7
Unable to work because of sickness or disability 0.1 0.1 0.1 -0.4 -0.2
Commuting to job workplace: Cycle 1.1 1.3 2.2 -1.5 -0.6
Myopia 0.2 0.3 0.5 -0.4 -0.7
Vascular/heart problems diagnosed by doctor 2.0 5.5 9.1 -3.0 -1.4
Cholesterol lowering medication 0.0 0.1 0.1 0.3 0.2
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.6 -0.4 -0.8
Pain experienced in last month 0.1 0.2 0.3 -0.5 0.0
Supplements: Calcium 0.2 0.2 0.4 -0.6 0.1
Basal cell carcinoma (self-reported) 2.0 2.4 3.2 -1.8 1.3
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.4 -0.2 0.6
Deep venous thrombosis (DVT) (self-reported) 0.0 0.1 0.1 0.2 -0.3
Heart disease (siblings) 1.2 1.4 2.6 -0.5 1.6
Alcohol drinker status: Previous 0.9 1.1 2.0 -1.4 0.3
Pack years of smoking 0.9 1.3 2.6 -0.0 1.6
Impedance of whole body 0.9 4.8 9.0 -3.0 0.8
Leg fat mass (left) 0.4 1.5 2.9 1.7 -0.2
Arm predicted mass (left) 3.8 19.4 27.0 3.4 -5.2