Hub : Genes

RP11-673E1.3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.0900	0.0430	0.00068	0.034	NA	0.017	NA	0.028	0.00740	NA	0.0440	NA	0.0140
2	GTEx	Artery Tibial	0.1239	0.0487	0.00014	0.004	NA	0.040	NA	0.035	0.15000	NA	0.0004	NA	0.0009
3	GTEx	Brain Putamen basal ganglia	0.1650	0.0770	0.00280	-0.012	NA	-0.013	NA	-0.005	0.82000	NA	1.0000	NA	0.4500
4	GTEx	Breast Mammary Tissue	0.0620	0.0330	0.00580	0.052	NA	0.010	NA	0.041	0.00110	NA	0.0940	NA	0.0037
5	GTEx	Breast Mammary Tissue (Male)	0.0450	0.0633	0.25000	0.025	NA	-0.008	NA	-0.002	0.08700	NA	0.5500	NA	0.3600
6	GTEx	Breast Mammary Tissue (Female)	0.0454	0.0364	0.09700	-0.009	NA	-0.010	NA	0.047	0.76000	NA	0.9700	NA	0.0150
7	GTEx	Whole Blood	0.0420	0.0210	0.00120	0.035	NA	0.019	NA	0.019	0.00035	NA	0.0062	NA	0.0067

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.7	1.1	1.8	1.4	0.3	-0.8	1.1	1.1	0.9	1.2
Bipolar Disorder or Schizophrenia	1.1	2.6	4.5	2.1	0.2	-1.3	1.7	1.7	1.6	1.8
Depressed Affect (Nagel 2018)	0.8	1.7	2.8	-1.1	0.9	1.3	-1.7	-1.7	-0.2	-1.6
Depression (Nagel 2018)	2.9	4.3	6.4	-2.0	0.5	2.1	-2.5	-2.5	-1.6	-2.5
Intelligence (Savage-Jansen 2018)	3.3	10.0	12.4	-3.4	-1.6	3.4	-3.5	-3.5	-2.8	-3.5
Neuroticism (Nagel 2018)	0.8	1.9	3.2	-1.1	1.4	1.2	-1.8	-1.8	0.0	-1.6
Schizophrenia (2018)	0.7	1.5	2.6	1.6	-0.1	-1.0	1.3	1.3	1.3	1.4
Schizophrenia vs Biploar Disorder	0.4	0.6	0.8	0.9	-0.4	-0.7	0.8	0.8	0.9	0.7
Worry (Nagel 2018)	0.3	0.7	2.6	-0.2	1.6	0.4	-0.8	-0.8	0.5	-0.8
Alzheimer’s Disease (in mother)	0.0	0.0	0.2	0.1	0.2	-0.1	0.1	0.1	0.5	0.0
Alzheimer’s Disease (in father)	1.9	2.1	2.6	1.5	1.6	-1.4	1.4	1.4	1.3	1.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.8	0.7	1.3	-0.8	0.7	0.7	0.8	0.6
Crohns Disease (2017)	4.3	9.5	11.6	-3.1	-2.7	3.2	-3.2	-3.2	-2.7	-3.4
Irritable Bowel Disease (IBD)	3.5	8.4	10.1	-2.7	-2.7	3.2	-3.0	-3.0	-2.5	-3.1
Ulcerative Colitis (UC)	1.0	1.9	4.9	-0.9	-2.2	1.4	-1.2	-1.2	-1.0	-1.3
Major Depression (MDD)	2.7	3.3	5.1	-1.9	-0.7	1.9	-2.2	-2.2	-1.0	-2.3
Reaction Time	0.6	1.1	2.8	0.9	1.7	-0.7	1.1	1.1	0.7	1.0
Verbal and Numeric Reasoning (VNR)	1.4	3.4	4.3	-2.1	-1.2	1.8	-2.0	-2.0	-1.8	-1.9
Breast Cancer	0.0	0.1	0.4	-0.2	0.0	-0.4	0.1	0.1	-0.6	0.2
Ovarian Cancer	2.3	3.1	6.9	-1.8	-2.6	1.2	-1.2	-1.2	-2.3	-1.2
Prostate Cancer	0.4	0.5	1.1	0.4	1.1	-0.6	0.7	0.7	0.8	0.7
Age at First Birth	0.7	1.0	2.3	1.5	0.6	-0.6	1.1	1.1	0.5	1.1
Bipolar Disorder (2011)	0.8	0.8	1.7	1.3	0.8	-0.3	0.9	0.9	0.8	1.0
Body Mass Index (BMI) (2010)	0.7	0.9	2.7	0.7	1.6	-0.9	0.9	0.9	-0.1	0.9
Coronary Artery Disease (CAD)	0.3	0.4	1.8	0.3	-1.3	-0.5	0.3	0.3	-0.4	0.4
Crohns Disease (2012)	1.8	2.9	5.0	-1.2	-2.2	1.8	-1.7	-1.7	-1.4	-1.7
Mean Putamen Volume	0.4	0.5	0.9	0.7	1.0	-0.4	0.6	0.6	0.9	0.6
Fasting Glucose	2.7	3.3	4.8	2.2	2.1	-1.5	1.5	1.5	1.5	2.1
HbA1C	10.0	11.1	17.9	3.4	2.6	-0.8	4.1	4.1	2.8	4.2
HDL Cholesterol	0.1	0.2	0.7	0.4	0.8	-0.3	0.4	0.4	-0.1	0.4
LDL Cholesterol	0.1	0.1	0.4	0.0	0.6	0.4	0.3	0.3	-0.2	0.2
Lupus	1.4	2.2	2.3	1.4	1.5	-1.5	1.5	1.5	1.4	1.5
Neuroticism (2016)	0.1	0.2	0.7	0.3	0.4	0.3	-0.2	-0.2	0.8	-0.2
Primary Biliary Cirrhosis	0.3	0.4	0.7	0.6	0.4	-0.6	0.7	0.7	0.1	0.8
Rheumatoid Arthritis	0.5	0.7	1.0	0.8	-1.0	-0.9	0.8	0.8	0.6	0.9
Schizophrenia (2014)	0.7	1.5	2.7	1.6	0.4	-0.6	1.2	1.2	1.6	1.3
Triglycerides	0.2	0.3	0.6	-0.8	-0.3	0.5	-0.5	-0.5	-0.6	-0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	0.4	-0.7	0.3	-0.1	-0.1	0.2	-0.2
Ulcerative Colitis	0.6	0.9	3.0	-0.5	-1.7	0.9	-0.8	-0.8	-0.2	-0.7
Blood Eosinophil Count	0.1	0.4	1.6	0.2	-1.3	-0.4	0.6	0.6	0.3	0.6
Blood Platelet Count	2.7	31.6	39.3	-6.3	-2.9	6.1	-5.9	-5.9	-5.8	-5.8
Blood Red Count	2.1	20.5	26.1	5.0	2.8	-4.7	5.1	5.1	3.2	5.1
Blood White Count	0.1	0.9	1.3	-0.9	-1.1	1.1	-0.8	-0.8	-1.1	-0.8
Heel T-Score	0.1	0.4	0.9	0.2	1.0	-0.9	0.6	0.6	0.5	0.6
BMI	0.8	4.5	15.7	2.0	4.0	-0.9	1.9	1.9	0.9	1.9
Height	2.5	47.7	59.1	-7.7	-7.2	5.7	-7.3	-7.3	-5.7	-7.2
Waist Hip Ratio (WHR)	0.9	4.2	8.5	1.5	-2.9	-1.8	2.0	2.0	2.0	1.9
Systolic Blood Pressure	0.5	2.4	4.9	-1.0	-2.2	2.2	-1.3	-1.3	-0.7	-1.4
Smoking Status	0.1	0.4	0.5	-0.5	0.2	0.5	-0.7	-0.7	-0.5	-0.7
Allergy or Eczema	0.3	0.8	1.2	-0.6	0.3	1.0	-1.0	-1.0	-1.1	-1.0
Cardiovascular Disease	0.5	1.6	2.5	1.6	1.0	-0.5	1.4	1.4	0.9	1.4
Hypothyroidism (self reported)	2.0	4.5	6.0	2.2	2.2	-2.0	2.0	2.0	2.4	2.0
Respiratory disease	0.5	1.1	1.6	-0.9	-1.0	1.1	-1.3	-1.3	-0.4	-1.2
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.3	0.3	0.3	-0.6	-0.0	-0.0	0.3	0.0
Lung FEV1/FVC ratio	3.7	18.9	43.6	3.9	6.6	-3.8	4.4	4.4	0.9	4.4
Lung FVC	0.4	2.0	7.2	-1.3	2.7	1.3	-0.7	-0.7	-1.4	-0.7
Neuroticism	1.3	3.1	5.4	-1.5	0.6	1.7	-2.3	-2.3	-0.3	-2.3
Chronotype (morning person)	0.1	0.2	0.3	-0.4	0.5	0.6	-0.3	-0.3	-0.3	-0.4
Hair Pigment	0.0	0.2	0.7	-0.1	-0.4	0.8	-0.4	-0.4	-0.7	-0.4
Tanning	0.1	0.9	1.2	-1.0	-1.0	0.7	-1.1	-1.1	-0.6	-1.0
Hand grip strength (left)	0.6	1.6	8.0	-0.7	-2.8	0.1	-0.1	-0.1	-1.7	-0.0
Number of treatments/medications taken	0.5	0.8	4.0	1.0	0.8	-0.1	0.1	0.1	2.0	0.1
Average weekly spirits intake	1.5	1.8	3.1	-1.8	-0.8	1.1	-1.5	-1.5	-0.9	-1.5
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.2	0.4	0.2	-0.3	-0.3	0.1	-0.2
Frequency of depressed mood in last 2 weeks	1.4	1.9	2.8	-1.2	-0.5	1.5	-1.7	-1.7	-0.9	-1.7
Hearing difficulty/problems: Yes	4.3	6.5	9.7	3.1	1.1	-2.8	2.6	2.6	2.6	2.6
Relative age of first facial hair	0.6	1.3	5.7	0.9	2.4	-0.6	0.8	0.8	0.6	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.0	1.3	1.4	-0.2	0.6	0.6	1.0	0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	-0.2	-0.2	0.1	-0.7	-0.7	0.1	-0.6
Ever had hysterectomy (womb removed)	0.7	0.8	1.5	1.0	1.2	-1.0	0.5	0.5	1.1	0.5
Systolic blood pressure, automated reading	0.2	0.7	1.1	-0.8	-0.7	1.1	-1.0	-1.0	0.3	-1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.1	0.1	1.0	-0.4	0.5	0.5	0.8	0.5
Angina	0.4	0.5	1.7	0.6	-1.3	-0.4	0.6	0.6	-0.1	0.6
Medication for hormone replacement therapy	0.4	0.4	0.7	0.8	0.8	-0.7	0.4	0.4	0.6	0.5
Vitamin and mineral supplements	0.3	0.4	1.7	0.6	0.6	-0.4	0.1	0.1	1.3	0.1
Supplements: Zinc	0.1	0.1	0.3	-0.2	-0.3	-0.3	-0.1	-0.1	-0.6	-0.0
Medication: Co-codamol	0.4	0.4	1.1	0.1	1.1	-0.9	0.2	0.2	1.0	0.2
Medication: Metformin	1.0	1.4	4.0	0.6	-0.3	-2.0	1.0	1.0	1.4	1.1
Diabetes (father)	0.7	0.8	1.9	-0.9	0.4	1.4	-0.9	-0.9	-0.4	-0.9
Diabetes (mother)	0.1	0.1	0.6	0.3	-0.8	-0.2	-0.1	-0.1	-0.3	-0.0
Severe depression (siblings)	0.1	0.1	0.4	-0.4	0.6	0.3	0.1	0.1	0.6	-0.1
Pack years adult smoking proportion	0.5	0.8	1.8	0.9	1.0	-1.3	0.6	0.6	0.7	0.7
Impedance of leg (right)	0.7	3.5	18.6	-1.0	-4.3	0.7	-1.1	-1.1	0.3	-1.2
Leg fat-free mass (left)	0.1	0.6	1.2	-0.5	1.1	0.4	-0.6	-0.6	-1.1	-0.5
Trunk fat percentage	0.2	0.7	3.8	0.2	1.9	0.4	-0.4	-0.4	0.4	-0.4
Hand grip strength (right)	0.8	2.2	6.2	-1.6	-2.5	0.8	-1.1	-1.1	-1.5	-1.0
Townsend deprivation index at recruitment	1.2	1.7	3.6	1.6	1.9	-0.8	1.2	1.2	0.7	1.2
Current tobacco smoking	0.6	1.0	2.2	0.9	1.1	-1.2	0.6	0.6	1.5	0.7
Average weekly fortified wine intake	0.3	0.3	0.9	0.2	0.2	-0.7	0.5	0.5	0.9	0.4
Maternal smoking around birth	2.7	3.9	5.7	2.2	1.8	-1.9	1.8	1.8	2.4	1.9
Fed-up feelings	0.5	1.0	3.2	-0.1	1.8	0.9	-0.9	-0.9	0.4	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	3.3	-0.9	0.1	1.6	-1.8	-1.8	-1.3	-1.7
Relative age voice broke	0.4	0.6	1.9	-0.7	-0.1	0.8	-0.6	-0.6	-1.4	-0.6
Taking other prescription medications	0.9	1.3	6.1	0.7	1.3	-1.0	0.2	0.2	2.5	0.2
Age when periods started (menarche)	0.2	0.4	2.3	-0.5	-0.3	0.1	-0.4	-0.4	-1.5	-0.3
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	5.0	0.9	2.2	-1.0	0.8	0.8	1.1	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.1	4.4	-2.1	0.8	1.8	-1.8	-1.8	-1.8	-1.9
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	-0.0	0.3	-0.3	0.4	0.4	-0.1	0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.5	0.0	0.3	0.3	-0.0	-0.0	-0.7	0.0
Serious illness, injury or assault to yourself	0.1	0.2	1.0	0.4	0.0	-0.1	0.0	0.0	1.0	-0.0
High blood pressure	0.9	2.6	3.9	2.0	0.8	-0.9	1.9	1.9	1.4	1.8
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.8	-0.3	0.3	0.5	-0.6	-0.6	-0.9	-0.5
Multivitamins +/- minerals	1.4	1.7	3.9	-1.5	-1.0	1.3	-1.1	-1.1	-2.0	-1.0
Stomach or abdominal pain in last month	0.7	0.9	1.6	-0.5	0.7	1.0	-1.3	-1.3	0.0	-1.2
Supplements: Glucosamine	2.2	2.8	4.8	1.5	-0.1	-2.2	2.0	2.0	0.8	2.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.4	-0.3	-1.2	-0.2	-0.1	-0.1	-0.4	-0.1
Medication: Atenolol	3.0	3.8	4.9	2.0	0.4	-1.8	2.2	2.2	2.1	2.1
Medication: Levothyroxine sodium	1.5	2.6	4.5	1.7	1.7	-1.4	1.4	1.4	2.1	1.4
Sitting height	2.7	19.0	23.2	-4.5	-0.9	4.8	-4.8	-4.8	-4.4	-4.8
Chronic bronchitis/emphysema (father)	2.3	2.7	3.4	-1.0	-1.8	1.8	-1.7	-1.7	-1.6	-1.7
High blood pressure (mother)	0.5	0.7	1.3	-0.1	-1.2	0.8	-0.9	-0.9	0.0	-1.0
Body mass index (BMI)	0.8	3.3	14.1	1.5	3.8	-0.9	1.3	1.3	0.7	1.4
Impedance of leg (left)	1.0	4.6	21.2	-1.5	-4.6	1.3	-1.5	-1.5	-0.5	-1.6
Leg predicted mass (left)	0.1	0.5	1.2	-0.4	1.1	0.4	-0.6	-0.6	-1.1	-0.5
Trunk fat mass	0.1	0.6	3.0	0.0	1.7	0.5	-0.5	-0.5	-0.1	-0.5
Waist circumference	0.2	0.8	2.0	0.8	1.4	-0.6	0.7	0.7	1.0	0.7
Number of incorrect matches in round	2.7	4.6	7.0	2.4	0.0	-1.9	2.7	2.7	1.4	2.6
Past tobacco smoking	0.8	1.4	2.5	1.1	0.4	-1.6	1.2	1.2	1.3	1.2
Alcohol usually taken with meals	0.6	1.0	2.6	-1.1	0.6	1.6	-0.7	-0.7	-1.2	-0.7
Nervous feelings	0.3	0.6	2.3	0.1	1.5	0.1	-0.4	-0.4	1.1	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.3	0.3	0.6	0.2	0.0	0.0	0.2	0.0
Hearing difficulty/problems with background noise	5.3	8.4	10.2	3.2	1.7	-2.9	3.2	3.2	2.7	3.1
Hair/balding pattern: Pattern 2	1.1	1.4	2.2	0.9	0.3	-1.4	1.4	1.4	0.4	1.5
Had menopause	0.8	1.0	2.3	1.1	0.8	-1.3	0.7	0.7	1.5	0.7
Had other major operations	0.5	0.6	1.2	-0.7	0.7	1.1	-0.8	-0.8	-0.5	-0.8
Forced vital capacity (FVC)	1.8	7.1	14.3	-2.8	-1.3	2.5	-2.6	-2.6	-3.8	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	2.8	-1.7	1.0	1.5	-1.2	-1.2	-1.3	-1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	-0.3	-0.4	1.0	-1.0	-1.0	-0.5	-1.0
Qualifications: None of the above	0.7	1.4	2.7	0.8	1.6	-1.4	0.8	0.8	1.6	0.9
Financial difficulties in last 2 years	0.2	0.3	2.0	-0.0	1.4	-0.3	0.2	0.3	-0.2	0.3
Mouth/teeth dental problems	0.5	0.8	4.3	0.1	-2.1	0.2	0.3	0.3	-1.1	0.3
Heart attack	0.9	1.2	2.0	0.9	0.1	-1.1	1.4	1.4	0.9	1.3
Allergy	0.4	0.9	1.3	0.6	0.0	-1.1	1.2	1.2	1.0	1.1
Pain all over the body in last month	1.0	1.1	2.8	1.3	1.7	-0.5	0.8	0.8	0.8	0.8
Diabetes (self-reported)	0.1	0.2	0.6	0.3	-0.7	-0.5	0.2	0.2	-0.1	0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.5	0.9	-0.9	0.5	0.5	0.4	0.5
Medication: Ramipril	0.4	0.5	1.6	0.8	1.3	-0.1	0.7	0.7	-0.2	0.6
Medication: Simvastatin	0.0	0.0	0.2	0.2	-0.1	0.4	-0.1	-0.1	-0.2	-0.1
Fluid intelligence score	1.3	2.8	3.3	-1.6	-1.7	1.4	-1.8	-1.8	-1.5	-1.8
Illnesses of siblings	0.4	0.5	2.2	0.7	1.5	-0.2	0.3	0.3	0.7	0.3
Neuroticism score	0.8	1.6	2.7	-0.9	1.0	0.9	-1.6	-1.6	0.6	-1.6
Weight	0.1	0.7	1.9	-0.5	1.4	0.7	-0.6	-0.6	-0.9	-0.6
Impedance of arm (right)	0.7	3.4	5.8	-1.6	-2.4	1.5	-2.1	-2.1	-0.5	-2.1
Arm fat percentage (right)	0.6	2.3	10.7	1.3	3.3	-0.6	0.9	0.9	0.9	0.9
Trunk fat-free mass	0.3	1.9	4.7	-1.5	-1.1	1.1	-1.1	-1.1	-2.2	-1.1
Hip circumference	0.4	1.7	2.8	-0.9	1.7	1.5	-1.3	-1.3	-0.9	-1.2
Time employed in main current job	0.2	0.3	0.6	0.3	0.8	0.1	0.6	0.6	-0.5	0.6
Alcohol intake versus 10 years previously	0.4	0.7	2.2	1.5	0.2	-0.5	0.8	0.8	0.6	0.8
Father’s age at death	1.4	1.8	2.8	-1.5	-1.1	1.3	-1.3	-1.3	-1.7	-1.3
Worrier / anxious feelings	0.2	0.5	1.4	0.3	1.2	0.5	-0.3	-0.3	1.0	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	0.7	1.0	0.0	0.4	0.4	0.4	0.4
Falls in the last year	0.6	0.8	1.4	-1.0	-0.3	0.9	-1.1	-1.1	0.0	-1.2
Hair/balding pattern: Pattern 3	0.5	0.7	1.1	-1.0	0.0	0.9	-0.9	-0.9	-0.6	-1.0
Number of live births	0.2	0.3	0.7	-0.9	0.7	0.0	-0.4	-0.4	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	8.0	-1.0	1.0	0.9	-0.7	-0.7	-2.8	-0.6
Pulse rate	0.1	0.2	1.2	-0.1	1.1	-0.2	-0.2	-0.2	0.5	-0.2
Happiness	0.2	0.2	1.3	0.1	-0.1	0.0	-0.2	-0.2	1.1	-0.2
Noisy workplace	1.2	1.4	2.1	-1.3	-0.3	1.4	-1.3	-1.3	-0.9	-1.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.8	0.2	-0.3	0.4	0.3	0.3	-0.9	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.1	-1.0	-1.1	0.7	-1.2	-1.2	-1.7	-1.1
Mouth/teeth dental problems: Dentures	0.2	0.4	1.5	0.0	1.2	-0.3	0.1	0.1	1.0	0.1
Asthma	0.2	0.4	0.8	-0.3	-0.6	0.9	-0.7	-0.7	0.3	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.0	-1.3	-1.0	1.3	-1.7	-1.7	-0.2	-1.7
Medication: Cholesterol lowering	0.2	0.3	0.7	0.8	0.6	-0.0	0.5	0.5	0.7	0.4
Depression (self-reported)	0.3	0.3	1.0	-0.5	1.0	0.4	-0.5	-0.5	0.6	-0.5
Medication: Lansoprazole	2.8	3.1	6.3	1.5	1.9	-1.5	1.5	1.5	2.5	1.6
Prospective memory result	0.5	0.6	1.1	0.4	1.0	-0.5	0.8	0.8	1.1	0.7
Lung cancer (father)	0.1	0.1	0.2	0.5	-0.4	-0.3	0.3	0.3	-0.2	0.3
Illnesses of mother	0.3	0.3	0.6	-0.2	-0.6	-0.3	0.6	0.6	-0.8	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	6.4	-0.2	1.1	0.6	-0.1	-0.1	-2.5	-0.0
Pulse wave Arterial Stiffness index	0.6	0.7	1.0	0.8	0.7	-0.9	1.0	1.0	0.4	1.0
Impedance of arm (left)	0.8	3.9	6.0	-1.7	-2.0	1.7	-2.4	-2.4	-0.6	-2.4
Arm fat mass (right)	0.3	1.1	7.2	0.4	2.7	0.2	0.1	0.1	0.1	0.1
Trunk predicted mass	0.3	1.6	4.4	-1.4	-0.9	1.0	-1.0	-1.0	-2.1	-1.0
Standing height	2.0	19.4	24.7	-4.6	-5.0	3.6	-4.5	-4.5	-3.9	-4.5
Length of working week for main job	1.3	1.4	4.2	-1.2	0.5	1.0	-1.0	-1.0	-2.0	-1.0
Exposure to tobacco smoke at home	2.5	2.8	3.9	1.6	1.8	-1.5	1.6	1.6	2.0	1.6
Breastfed as a baby	0.2	0.2	0.5	-0.5	-0.2	0.7	-0.5	-0.5	0.2	-0.6
Tense / ‘highly strung’	1.4	2.4	3.9	-1.4	1.0	1.4	-2.0	-2.0	-0.3	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	2.4	-0.8	0.6	1.5	-1.4	-1.4	-0.1	-1.4
Hair/balding pattern: Pattern 4	0.1	0.1	0.6	0.8	0.0	0.0	-0.1	-0.1	0.6	-0.1
Birth weight of first child	1.2	2.2	4.5	-1.3	-1.0	2.1	-1.3	-1.3	-1.6	-1.3
Peak expiratory flow (PEF)	1.4	3.3	13.6	1.1	3.7	-0.7	1.4	1.4	-1.2	1.5
Pulse wave reflection index	1.5	1.9	2.9	1.5	0.7	-1.7	1.5	1.5	0.5	1.6
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.3	-0.6	-0.1	1.5	-1.0	-1.0	-0.8	-1.1
Loud music exposure frequency	0.3	0.4	1.7	0.2	-0.7	0.0	0.3	0.3	-1.3	0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.8	-0.6	-1.7	0.6	-0.2	-0.2	-1.6	-0.2
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	2.3	1.1	1.2	-1.5	1.3	1.3	1.1	1.4
Blood clot in the leg (DVT)	1.6	2.1	3.3	-1.1	-0.4	1.6	-1.8	-1.8	-0.8	-1.8
Medication: Paracetamol	0.7	1.2	4.0	-0.7	2.0	0.9	-1.0	-1.0	0.0	-0.9
Headache pain in last month	0.6	1.0	2.9	0.1	1.7	0.5	-0.8	-0.8	1.4	-0.8
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	1.0	0.2	0.1	-1.0	0.4	0.4	0.0	0.5
Glaucoma (self-reported)	0.0	0.0	0.1	-0.1	0.4	0.2	-0.1	-0.1	0.0	-0.1
Gout (self-reported)	0.2	0.3	0.5	0.7	0.6	-0.4	0.4	0.4	0.5	0.5
Hypothyroidism/myxoedema (self-reported)	2.6	5.2	6.0	2.3	2.0	-2.3	2.2	2.2	2.4	2.3
Medication: Amlodipine	1.1	1.5	4.5	1.3	1.3	-0.7	0.9	0.9	2.1	0.8
Medication: Ventolin 100micrograms inhaler	2.1	2.7	4.3	-1.7	-1.2	2.1	-1.8	-1.8	-0.5	-1.9
Birth weight	1.1	2.5	4.3	-2.1	0.4	1.4	-1.8	-1.8	-0.9	-1.9
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.5	0.6	0.1	-0.5	0.2	0.2	0.7	0.2
High blood pressure (siblings)	0.9	1.3	3.1	-1.1	-1.7	1.0	-1.0	-1.0	-1.0	-0.9
Forced vital capacity (FVC), Best measure	1.3	4.8	11.8	-2.2	-0.6	2.1	-2.0	-2.0	-3.4	-1.9
Body fat percentage	0.3	1.1	5.8	0.9	2.4	-0.3	0.4	0.4	0.9	0.4
Leg fat percentage (right)	0.9	3.3	4.7	1.9	2.2	-1.4	1.8	1.8	1.9	1.8
Arm fat-free mass (right)	0.1	0.6	1.8	-0.8	-0.2	0.6	-0.7	-0.7	-1.3	-0.6
Exposure to tobacco smoke outside home	2.8	3.7	3.9	1.9	2.0	-1.9	2.0	2.0	1.9	1.9
Comparative body size at age 10	1.1	3.0	6.1	1.5	2.5	-1.7	1.7	1.7	1.0	1.7
Number of full brothers	0.7	0.9	1.4	1.1	0.1	-0.9	1.0	1.0	1.2	1.0
Worry too long after embarrassment	0.1	0.1	0.5	-0.0	0.4	-0.0	-0.1	-0.1	0.7	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.9	1.4	2.0	-0.5	0.5	0.5	1.7	0.4
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	-0.5	-0.4	0.4	-0.7	-0.7	0.1	-0.7
Number of children fathered	0.4	0.4	0.6	-0.8	0.7	0.7	-0.6	-0.6	0.0	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.8	-0.7	-1.7	0.9	-0.6	-0.6	-1.6	-0.7
Age at first live birth	1.1	1.9	4.0	-1.0	-2.0	1.8	-0.7	-0.7	-1.8	-0.8
Pulse wave peak to peak time	0.9	1.1	1.4	-1.0	-1.0	1.0	-1.2	-1.2	-0.6	-1.2
Health satisfaction	0.3	0.4	0.8	0.5	0.9	-0.4	0.5	0.5	0.9	0.5
Shortness of breath walking on level ground	0.3	0.3	1.6	0.7	1.3	-0.1	0.1	0.1	-0.2	0.2
Qualifications: College or University degree	0.1	0.4	1.2	-0.5	-0.9	1.1	-0.1	-0.1	-0.7	-0.2
Eye problems/disorders: None of the above	0.5	0.6	3.2	0.6	-1.8	-0.6	0.3	0.3	0.4	0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.5	-0.2	-0.7	0.1	-0.3	-0.3	0.3	-0.3
Emphysema/chronic bronchitis	1.0	1.1	1.7	-1.3	-0.9	1.3	-1.1	-1.1	-0.6	-1.0
Medication for pain relief, constipation, heartburn	0.7	1.2	2.7	0.7	-1.6	-0.9	1.0	1.0	-0.9	1.0
Neck or shoulder pain in last month	0.9	1.3	4.0	0.9	2.0	-0.6	1.0	1.0	0.9	1.0
Medication: Blood pressure	0.0	0.0	0.1	0.3	-0.2	0.1	0.2	0.2	0.1	0.1
Angina (self-reported)	0.4	0.5	1.7	0.7	-1.3	-0.4	0.6	0.6	-0.1	0.6
Migraine (self-reported)	2.4	3.0	4.3	-2.1	-0.3	1.6	-2.1	-2.1	-1.1	-2.0
Medication: Ibuprofen	1.7	2.0	3.3	-1.4	-0.8	1.4	-1.8	-1.8	-0.5	-1.8
Medication: Allopurinol	0.3	0.3	0.7	0.8	0.6	-0.4	0.6	0.6	-0.2	0.6
Medication: Omeprazole	0.4	0.5	2.2	-0.4	1.5	0.4	-0.6	-0.6	0.0	-0.5
Medication: Seretide 50 evohaler	0.0	0.1	0.1	0.4	-0.1	0.1	-0.3	-0.3	0.2	-0.2
Mean time to correctly identify matches	0.9	1.7	3.5	1.1	1.9	-1.1	1.1	1.1	1.5	1.0
Heart disease (mother)	0.1	0.1	0.5	0.0	-0.4	0.2	0.1	0.1	0.7	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.8	0.1	0.9	0.3	-0.3	-0.3	-0.6	-0.3
Whole body fat mass	0.2	0.7	4.4	0.3	2.1	0.3	-0.1	-0.1	0.3	-0.1
Leg fat mass (right)	0.3	1.1	4.3	1.0	2.1	-0.4	0.8	0.8	0.6	0.8
Arm predicted mass (right)	0.2	0.9	2.4	-1.0	-0.2	0.8	-0.8	-0.8	-1.6	-0.8
Pulse rate, automated reading	0.3	0.9	1.6	-0.9	-0.3	1.0	-1.2	-1.2	-0.3	-1.2
Alcohol intake frequency.	0.0	0.0	0.1	0.2	0.3	-0.1	-0.2	-0.2	0.0	-0.1
Comparative height size at age 10	1.5	8.0	11.0	-2.8	-3.0	2.0	-3.3	-3.3	-1.5	-3.3
Number of full sisters	0.6	0.8	1.4	-1.0	-0.7	0.6	-0.8	-0.8	-1.2	-0.9
Suffer from ‘nerves’	0.2	0.4	1.1	0.1	0.6	-1.0	0.3	0.3	1.0	0.3
Overall health rating	1.4	3.0	6.9	1.8	1.6	-1.4	1.5	1.5	2.6	1.5
Chest pain or discomfort	0.1	0.1	0.3	-0.2	-0.3	0.4	-0.2	-0.2	0.5	-0.2
Had major operations	0.7	0.8	5.1	0.2	-2.3	-0.4	0.4	0.4	-0.2	0.4
Age at last live birth	0.9	1.3	3.1	-0.7	-1.8	1.4	-0.5	-0.5	-1.6	-0.6
Family relationship satisfaction	0.6	0.8	2.8	1.1	-0.4	-0.8	0.4	0.4	1.7	0.4
Leg pain on walking	0.5	0.6	3.8	0.3	1.9	-0.7	0.2	0.2	-0.1	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.4	-0.2	-0.4	0.7	-0.7	-0.7	-0.6	-0.7
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.5	-0.4	-0.3	-0.4	-0.4	-0.1	-0.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	1.8	0.8	1.2	-0.8	1.3	1.3	0.8	1.2
Medication: Aspirin	0.1	0.1	0.2	0.3	-0.4	0.1	0.3	0.3	0.4	0.2
Supplements: Vitamin C	0.9	1.1	1.8	1.1	0.7	-0.8	1.3	1.3	0.3	1.4
Knee pain experienced in last month	1.1	1.8	3.0	1.3	1.7	-1.4	1.3	1.3	0.8	1.3
Hypertension (Self-reported)	1.0	2.6	4.0	2.0	0.1	-1.1	2.0	2.0	1.2	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.6	-0.1	1.6	0.8	-0.9	-0.9	0.6	-0.9
Illnesses of father: Heart disease	1.1	1.5	2.0	1.3	0.6	-0.8	1.4	1.4	1.4	1.4
Illnesses of siblings: Diabetes	0.1	0.1	0.6	-0.1	0.1	-0.7	0.1	0.1	0.2	0.1
Smoking status: Previous	0.5	0.8	1.5	-0.8	-0.6	1.2	-0.7	-0.7	-1.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.3	0.0	-0.3	-0.2	0.1	0.1	-0.5	0.2
Whole body fat-free mass	0.2	1.2	3.4	-1.2	-0.2	0.9	-1.0	-1.0	-1.9	-0.9
Leg fat-free mass (right)	0.2	1.0	2.6	-0.8	0.8	0.8	-0.9	-0.9	-1.6	-0.8
Arm fat percentage (left)	0.6	2.3	11.6	1.3	3.4	-0.5	0.8	0.8	0.9	0.8
Average weekly red wine intake	0.4	0.5	1.3	-0.3	-0.9	1.2	-0.5	-0.5	-0.8	-0.6
Handedness (chirality/laterality): Left-handed	0.9	1.0	3.2	-1.4	-1.8	0.5	-0.5	-0.5	-1.0	-0.5
Mood swings	2.5	4.5	6.8	-1.7	-0.4	2.3	-2.6	-2.6	-1.7	-2.6
Loneliness, isolation	1.0	1.3	2.1	-1.3	-0.5	0.9	-1.5	-1.5	-0.7	-1.4
Long-standing illness, disability or infirmity	1.7	2.7	6.4	2.3	0.3	-1.5	1.2	1.2	2.5	1.3
Ever had bowel cancer screening	0.2	0.2	0.8	0.4	-0.0	-0.9	0.2	0.2	0.6	0.2
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.2	0.4	-0.7	0.4	0.4	0.5	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.5	-0.2	0.7	0.1	0.2	0.2	0.1	0.1
Friendships satisfaction	0.5	0.6	3.0	0.9	-0.2	-0.6	-0.0	-0.0	1.7	0.0
Qualifications: nursing, teaching	0.3	0.5	1.3	-0.5	-1.2	0.6	-0.5	-0.5	-1.0	-0.5
Commuting to job workplace: Walk	0.5	0.6	1.7	-0.0	-0.5	1.2	-0.5	-0.5	-1.3	-0.5
Eye problems/disorders: Cataract	0.9	1.1	1.9	-1.0	1.4	1.2	-1.1	-1.1	-0.3	-1.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	2.6	-0.5	1.4	1.6	-1.3	-1.3	-0.7	-1.4
Medication for cholesterol	1.4	2.1	2.7	-1.5	-0.9	1.3	-1.6	-1.6	-1.4	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	-0.7	0.4	0.9	-0.7	-0.7	-0.2	-0.7
Back pain experienced in last month	1.7	2.5	6.7	-0.7	2.6	1.6	-1.6	-1.6	-0.3	-1.5
Mineral and other dietary supplements	2.2	3.0	4.0	-1.6	-1.3	2.0	-2.0	-2.0	-1.0	-2.0
Breast cancer (self-reported)	2.0	2.4	4.6	1.8	2.1	-1.4	1.3	1.3	1.5	1.3
Asthma (self-reported)	0.1	0.2	0.3	-0.1	-0.5	0.6	-0.5	-0.5	0.4	-0.4
Osteoporosis (self-reported)	0.2	0.2	1.0	0.2	-1.0	0.2	0.1	0.1	-0.5	0.1
Osteoarthritis (self-reported)	1.4	1.8	4.1	1.1	2.0	-0.9	1.4	1.4	0.8	1.4
Medication: Aspirin	0.1	0.1	0.5	0.2	-0.7	0.1	0.2	0.2	0.4	0.1
Medication: Gliclazide	0.1	0.2	0.9	0.1	-0.4	-0.9	-0.2	-0.2	-0.0	-0.1
Illnesses of father: None of the above (group 1)	0.4	0.4	1.1	-1.1	-0.2	0.0	-0.7	-0.7	-0.7	-0.7
Smoking status: Current	0.4	0.6	1.9	0.6	1.1	-0.8	0.3	0.3	1.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	5.2	0.6	2.3	-0.4	0.6	0.6	-0.1	0.6
Whole body water mass	0.2	1.0	3.0	-1.1	-0.2	0.7	-0.9	-0.9	-1.7	-0.8
Leg predicted mass (right)	0.2	0.9	2.4	-0.8	0.8	0.7	-0.9	-0.9	-1.6	-0.8
Arm fat mass (left)	0.3	1.1	7.0	0.5	2.7	0.1	0.2	0.2	0.0	0.2
Number of self-reported non-cancer illnesses	0.2	0.4	2.2	0.4	-0.2	0.3	-0.2	-0.2	1.5	-0.3
Average weekly champagne plus white wine intake	0.0	0.1	0.2	-0.5	0.4	0.2	0.0	0.0	0.1	0.0
Miserableness	0.3	0.5	2.0	-0.1	1.4	0.3	-0.7	-0.7	0.1	-0.7
Guilty feelings	3.3	4.9	7.0	-2.3	0.0	2.2	-2.6	-2.6	-1.8	-2.6
Wears glasses or contact lenses	0.3	0.4	1.5	0.2	0.8	-0.4	0.3	0.3	1.2	0.2
Ever taken oral contraceptive pill	0.6	0.6	1.1	-0.5	0.7	1.0	-0.8	-0.8	-0.7	-0.8
Hearing aid user	1.1	1.3	4.3	1.5	0.6	-0.8	0.7	0.7	2.1	0.7
Mother’s age at death	0.3	0.3	1.6	-0.2	1.3	-0.4	0.0	0.0	0.7	-0.0
Financial situation satisfaction	0.4	0.5	1.7	0.7	0.3	-0.3	0.7	0.7	1.3	0.6
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.7	-0.7	1.3	1.0	-0.7	-0.7	0.3	-0.7
Commuting to job workplace: Public transport	0.8	0.9	2.4	-0.7	-1.3	1.1	-0.4	-0.4	-1.6	-0.5
Eye problems/disorders: Glaucoma	0.2	0.2	1.0	-0.4	1.0	0.4	-0.1	-0.1	0.2	-0.1
Medication: Blood pressure	0.3	0.6	1.1	0.5	-0.3	-0.0	1.1	1.1	0.7	1.0
Pain type(s) experienced in last month: Hip pain	2.5	3.1	4.1	-1.4	-0.0	1.8	-2.0	-2.0	-2.0	-2.0
Supplements: Fish oil (including cod liver oil)	1.3	1.7	2.1	1.2	1.3	-1.5	1.4	1.4	1.0	1.3
High cholesterol (Self-reported)	0.1	0.2	0.7	-0.2	-0.2	0.6	-0.1	-0.1	-0.9	-0.1
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.7	-0.2	0.1	0.7	0.7	0.0	0.6
Medication: Paracetamol	0.6	0.9	1.8	-0.6	1.3	1.1	-1.0	-1.0	-0.2	-0.9
Medication: Lisinopril	2.2	2.8	4.9	1.8	-0.3	-1.6	1.7	1.7	2.2	1.7
Medication: Atorvastatin	2.3	2.8	3.3	1.8	1.3	-1.8	1.7	1.7	1.7	1.7
Illnesses of father: High blood pressure	0.9	1.1	2.1	-0.7	-1.5	0.9	-1.1	-1.1	-0.6	-1.1
Alcohol drinker status: Never	0.1	0.1	0.3	-0.5	-0.1	0.3	-0.3	-0.3	0.3	-0.3
Ever smoked	1.2	2.2	2.9	-1.6	-0.3	1.7	-1.6	-1.5	-1.6	-1.5
Basal metabolic rate	0.2	0.9	2.5	-1.0	0.2	0.8	-0.9	-0.9	-1.6	-0.8
Leg fat percentage (left)	0.7	2.7	5.6	1.6	2.4	-1.1	1.6	1.6	1.5	1.6
Arm fat-free mass (left)	0.1	0.4	1.2	-0.8	-0.1	0.5	-0.5	-0.5	-1.1	-0.4
Number of operations (self-reported)	0.1	0.1	0.3	-0.4	0.3	0.5	-0.3	-0.3	-0.4	-0.3
Average weekly beer plus cider intake	0.8	1.2	2.0	0.9	-0.7	-1.3	1.3	1.3	0.2	1.4
Irritability	0.5	0.8	1.2	-0.9	-0.2	0.9	-1.1	-1.1	-0.1	-1.1
Risk taking	0.1	0.2	1.1	-0.4	0.2	-0.3	-0.1	-0.1	-1.1	0.0
Ever had prostate specific antigen (PSA) test	0.5	0.5	0.7	0.4	0.9	0.7	0.8	0.8	0.7	0.8
Fractured/broken bones in last 5 years	0.8	1.0	1.6	-1.0	-0.5	1.0	-1.2	-1.2	-0.5	-1.3
Age started oral contraceptive pill	0.5	0.6	1.7	0.5	1.3	-0.6	0.6	0.6	0.9	0.6
Diastolic blood pressure, automated reading	0.1	0.3	0.9	0.5	0.8	0.3	0.0	0.0	1.0	0.0
Ever depressed for a whole week	0.2	0.3	1.2	1.1	0.5	-0.1	-0.1	-0.1	0.8	-0.0
Unable to work because of sickness or disability	0.6	0.8	1.7	1.3	0.8	-0.5	1.0	1.0	0.6	0.9
Commuting to job workplace: Cycle	0.2	0.2	0.7	-0.1	-0.5	0.4	0.3	0.3	-0.8	0.2
Myopia	0.1	0.2	0.6	0.5	-0.8	0.0	-0.2	-0.2	0.4	-0.1
Vascular/heart problems diagnosed by doctor	1.3	3.5	5.3	-2.3	-0.7	1.2	-2.2	-2.2	-1.8	-2.1
Cholesterol lowering medication	0.2	0.3	0.6	0.5	0.1	-0.5	0.7	0.7	0.2	0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.7	-0.9	1.3	0.9	-1.0	-1.0	-0.1	-1.0
Pain experienced in last month	0.7	1.2	7.2	-0.0	-2.7	-0.4	0.5	0.5	-0.1	0.4
Supplements: Calcium	1.3	1.5	5.5	-1.4	-1.4	0.6	-0.5	-0.5	-2.3	-0.5
Basal cell carcinoma (self-reported)	0.5	0.6	2.6	0.1	1.6	0.4	0.2	0.2	1.1	0.2
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.6	0.8	0.0	-1.0	1.2	1.2	0.7	1.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	2.9	-1.2	-0.5	1.4	-1.7	-1.7	-0.6	-1.6
Heart disease (siblings)	0.6	0.7	2.2	0.5	-1.5	-0.8	0.8	0.9	-0.1	0.8
Alcohol drinker status: Previous	0.7	0.8	2.9	-0.7	-0.2	0.7	-0.7	-0.7	-1.7	-0.6
Pack years of smoking	0.4	0.6	1.5	0.8	0.9	-1.2	0.5	0.5	0.6	0.6
Impedance of whole body	1.0	5.1	12.8	-1.7	-3.6	1.8	-2.3	-2.3	-0.6	-2.4
Leg fat mass (left)	0.3	1.0	4.9	0.8	2.2	-0.3	0.6	0.6	0.4	0.6
Arm predicted mass (left)	0.1	0.6	1.9	-0.9	-0.4	0.6	-0.5	-0.5	-1.4	-0.5