Hub : Genes

RP11-676J12.4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.230	0.0831	6.6e-03	0.016	NA	0.010	NA	0.009	8.2e-02	NA	1.4e-01	NA	1.5e-01
2	GTEx	Artery Coronary	0.270	0.0910	3.5e-03	0.031	NA	-0.009	NA	0.023	3.3e-02	NA	8.9e-01	NA	5.6e-02
3	GTEx	Brain Cerebellar Hemisphere	0.404	0.0970	9.9e-05	0.089	NA	0.197	NA	0.177	2.8e-03	NA	9.0e-06	NA	2.7e-05
4	GTEx	Colon Transverse	0.186	0.0730	9.6e-03	0.060	NA	0.029	NA	0.035	8.2e-04	NA	1.6e-02	NA	8.8e-03
5	GTEx	Skin Sun Exposed Lower leg	0.234	0.0500	5.3e-08	0.158	NA	0.123	NA	0.145	5.0e-13	NA	2.4e-10	NA	5.2e-12
6	GTEx	Thyroid	0.080	0.0350	8.7e-03	0.065	NA	0.051	NA	0.057	9.7e-06	NA	9.1e-05	NA	3.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.4	0.7	3.0	-0.5	-1.7	-0.6	0.5	-0.2	-0.2
Bipolar Disorder or Schizophrenia	0.2	0.5	1.6	-1.0	-1.2	0.4	0.1	0.2	-0.2
Depressed Affect (Nagel 2018)	0.2	0.3	1.1	-0.6	1.1	0.3	0.4	-0.3	0.1
Depression (Nagel 2018)	0.6	0.9	2.8	-1.0	1.7	1.0	-0.1	-0.3	0.4
Intelligence (Savage-Jansen 2018)	0.5	1.5	3.9	1.1	-2.0	0.2	1.5	0.8	1.0
Neuroticism (Nagel 2018)	0.5	1.2	2.5	-0.9	1.0	0.4	-1.2	-1.6	-1.2
Schizophrenia (2018)	0.1	0.2	0.5	-0.7	-0.3	0.6	-0.2	0.4	-0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.7	1.4	3.0	-0.4	-0.5	0.3	-1.6	-1.5	-1.7
Alzheimer’s Disease (in mother)	1.1	1.2	4.1	0.1	-2.0	-1.3	0.8	-0.7	-0.8
Alzheimer’s Disease (in father)	0.5	0.5	1.7	0.9	1.3	0.0	-0.1	-0.4	0.6
Alzheimer’s Disease (including proxy)	0.5	0.8	1.4	0.9	-1.0	-1.2	0.6	-1.0	-0.4
Crohns Disease (2017)	0.2	0.5	1.9	-1.4	-0.3	-0.8	0.2	0.0	-0.5
Irritable Bowel Disease (IBD)	0.2	0.4	0.7	-0.7	0.7	0.6	0.3	0.7	0.9
Ulcerative Colitis (UC)	0.5	0.9	1.9	0.2	1.1	1.4	-0.1	0.6	1.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.9	3.6	9.3	-3.0	-0.3	-0.9	-2.5	-1.6	-1.6
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.8	0.4	-0.8	-0.7	-0.9	-0.8	-0.3
Breast Cancer	0.4	1.1	2.1	-1.4	-1.3	-1.1	-0.6	-0.7	-0.8
Ovarian Cancer	0.4	0.6	1.4	1.2	1.0	0.8	-0.0	0.5	0.1
Prostate Cancer	3.6	5.0	6.8	0.3	2.6	2.5	2.3	2.4	2.4
Age at First Birth	3.3	4.8	6.0	-2.3	-1.4	-2.2	-2.3	-2.5	-2.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.3	1.7	2.9	-1.4	-0.6	-1.4	-1.0	-1.7	-1.4
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	1.2	1.9	7.7	-2.8	-0.7	-0.4	-0.9	-0.7	-1.2
Mean Putamen Volume	0.4	0.4	2.2	-1.5	-0.3	0.1	-0.3	-0.5	0.2
Fasting Glucose	0.5	0.7	1.3	-1.0	-1.0	0.4	-0.5	-0.4	-1.2
HbA1C	0.1	0.1	0.8	0.1	-0.9	0.1	-0.1	0.1	-0.2
HDL Cholesterol	0.1	0.2	0.4	0.6	0.0	0.4	-0.7	-0.4	-0.4
LDL Cholesterol	0.9	1.5	3.0	1.2	1.7	0.9	1.0	0.8	1.4
Lupus	0.7	1.0	3.0	-1.7	0.5	1.5	0.3	0.4	0.8
Neuroticism (2016)	0.5	0.7	3.6	1.9	-0.5	-0.2	0.0	-0.4	0.4
Primary Biliary Cirrhosis	0.3	0.4	1.0	-0.7	-0.1	-0.5	1.0	0.6	0.6
Rheumatoid Arthritis	0.6	0.8	2.2	-1.5	1.1	0.3	-0.8	-0.6	0.2
Schizophrenia (2014)	0.2	0.4	1.9	-0.7	-0.0	1.4	0.0	0.4	0.2
Triglycerides	0.2	0.4	1.0	-0.8	0.4	0.2	0.5	1.0	0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.4	0.6	1.4	-1.0	1.2	0.6	-0.5	-0.2	0.8
Blood Eosinophil Count	1.1	8.8	14.3	-1.7	-1.7	-3.5	-3.2	-3.3	-3.8
Blood Platelet Count	0.3	3.4	7.2	-0.1	1.7	2.7	1.2	2.0	2.3
Blood Red Count	0.1	1.0	2.6	0.4	-1.2	-1.2	-0.1	-0.2	-1.6
Blood White Count	0.1	0.8	3.0	1.7	-0.8	-0.4	-0.0	0.5	-0.7
Heel T-Score	1.2	9.3	45.7	6.8	1.4	0.1	0.7	2.4	1.5
BMI	0.0	0.2	0.3	-0.0	0.5	0.5	0.6	0.5	0.3
Height	0.6	12.2	31.0	-0.4	-1.1	-1.5	-5.6	-4.8	-3.9
Waist Hip Ratio (WHR)	0.1	0.5	1.9	1.4	-0.8	0.1	-0.1	0.5	0.6
Systolic Blood Pressure	0.9	4.4	11.7	1.1	0.1	0.5	3.4	2.8	2.3
Smoking Status	0.2	0.5	0.8	-0.9	-0.0	0.8	0.9	0.8	0.6
Allergy or Eczema	0.1	0.2	0.3	0.5	0.4	0.3	-0.6	-0.4	-0.1
Cardiovascular Disease	0.9	3.0	7.5	-0.2	0.9	1.5	2.7	2.0	1.9
Hypothyroidism (self reported)	0.2	0.5	1.1	-0.8	0.9	0.2	0.6	1.1	0.0
Respiratory disease	0.3	0.6	1.0	-0.9	-0.7	-1.0	0.9	0.1	-0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.2	0.2	-0.3	0.0	1.1	1.0	-0.0
Lung FEV1/FVC ratio	0.3	1.4	3.5	0.1	0.8	1.9	0.1	1.2	1.7
Lung FVC	0.3	1.5	8.5	2.9	0.1	0.4	0.2	-0.3	-0.2
Neuroticism	0.8	2.0	5.0	-0.7	0.6	-0.1	-1.8	-2.2	-1.6
Chronotype (morning person)	0.3	0.6	2.3	-0.6	-1.5	0.5	-0.8	0.0	-0.5
Hair Pigment	0.1	2.1	3.7	0.7	1.4	0.8	1.6	1.8	1.9
Tanning	0.1	0.7	2.5	1.6	-0.7	0.3	0.5	0.9	0.0
Hand grip strength (left)	0.1	0.3	0.8	0.9	-0.2	-0.4	-0.5	-0.6	0.3
Number of treatments/medications taken	0.4	0.7	1.6	0.1	-0.2	-0.4	1.3	1.1	1.0
Average weekly spirits intake	0.1	0.2	0.4	0.6	-0.1	-0.5	0.0	-0.5	0.0
Sensitivity / hurt feelings	0.6	1.0	2.4	0.2	1.5	0.7	-1.1	-1.1	-0.9
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.2	-0.1	0.9	1.5	0.2	0.9	0.4
Hearing difficulty/problems: Yes	0.3	0.5	1.5	-0.4	1.2	1.2	-0.3	0.3	-0.1
Relative age of first facial hair	0.8	1.6	4.1	-1.1	2.0	2.0	-0.1	0.4	0.7
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	4.5	-0.2	-0.6	0.7	2.1	1.1	1.2
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.3	1.5	-0.9	0.2	1.4	1.1	1.0
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	-0.2	0.6	0.7	-0.3	0.7	-0.2
Systolic blood pressure, automated reading	1.0	2.8	5.0	0.5	1.7	0.9	2.2	1.8	2.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	3.9	2.0	0.4	0.1	-0.5	-0.2	0.3
Angina	0.6	0.8	2.4	0.3	0.6	1.6	0.2	0.9	1.1
Medication for hormone replacement therapy	1.1	1.2	2.3	1.0	-0.4	0.0	1.3	1.4	1.5
Vitamin and mineral supplements	0.5	0.6	1.6	0.3	0.3	-0.5	-1.3	-0.9	-1.0
Supplements: Zinc	0.3	0.3	0.9	0.0	0.3	-0.3	-0.0	-1.0	-0.8
Medication: Co-codamol	0.4	0.5	0.9	0.5	-0.5	-0.1	0.9	0.9	0.9
Medication: Metformin	0.1	0.1	0.6	0.1	-0.1	-0.0	0.8	0.4	-0.0
Diabetes (father)	0.2	0.3	0.8	-0.7	0.9	0.5	0.3	-0.1	0.3
Diabetes (mother)	1.2	1.5	3.1	1.8	-0.3	0.8	1.4	1.5	1.2
Severe depression (siblings)	2.3	2.5	9.6	0.3	-1.8	-3.1	0.2	-0.5	-1.4
Pack years adult smoking proportion	0.1	0.1	0.6	-0.8	0.2	-0.2	-0.2	-0.1	0.2
Impedance of leg (right)	0.3	1.6	6.7	-0.7	-2.6	-0.8	1.1	-0.0	0.7
Leg fat-free mass (left)	0.5	2.5	6.6	0.9	0.9	-0.4	-2.6	-2.0	-1.7
Trunk fat percentage	0.2	1.0	2.6	-0.8	-0.1	-0.9	-0.7	-1.6	-1.1
Hand grip strength (right)	0.2	0.6	1.5	1.2	0.6	-0.2	-0.1	0.1	1.2
Townsend deprivation index at recruitment	0.6	0.8	2.1	-0.2	1.5	1.1	0.5	1.1	0.2
Current tobacco smoking	0.5	0.8	2.2	-1.4	1.5	0.2	-0.8	-0.3	0.0
Average weekly fortified wine intake	0.1	0.1	0.2	0.5	-0.3	0.2	0.2	0.3	-0.2
Maternal smoking around birth	0.2	0.2	0.7	0.4	-0.5	-0.8	0.4	0.0	-0.5
Fed-up feelings	0.2	0.3	0.6	0.0	0.8	0.1	-0.7	-0.1	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	0.1	1.2	0.9	-0.5	-0.8	0.2
Relative age voice broke	0.7	1.1	2.3	0.7	1.4	0.3	-1.5	-0.7	-1.1
Taking other prescription medications	0.6	0.9	5.1	-2.2	-0.1	-0.1	0.5	-0.1	0.6
Age when periods started (menarche)	0.5	1.1	3.2	0.2	-1.1	-0.1	-1.8	-1.0	-1.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.0	0.3	0.3	-0.2	-0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	12.7	3.6	1.2	0.2	0.8	0.8	0.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	-0.2	0.3	1.2	0.9	0.4	0.8
Qualifications: CSEs or equivalent	0.7	0.9	2.1	-0.9	1.5	1.4	-0.4	0.3	0.1
Serious illness, injury or assault to yourself	0.6	0.7	1.3	-1.0	0.6	0.9	0.6	1.1	0.6
High blood pressure	1.6	4.4	9.9	1.6	0.9	1.5	3.1	2.3	2.4
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.5	1.2	0.3	0.1	0.3	-0.1	0.5
Multivitamins +/- minerals	1.3	1.7	3.7	1.0	0.3	0.3	1.7	1.5	1.9
Stomach or abdominal pain in last month	0.2	0.3	1.1	-0.0	0.6	1.1	-0.4	0.1	-0.3
Supplements: Glucosamine	2.3	3.0	5.6	0.9	-0.9	2.4	1.7	1.8	2.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.6	-0.7	-0.1	-0.8	-1.6	-1.2	-1.3
Medication: Atenolol	0.8	1.0	4.8	0.4	-0.2	-0.2	2.2	0.6	0.7
Medication: Levothyroxine sodium	0.1	0.2	1.1	-1.0	-0.1	-0.1	0.3	0.3	-0.2
Sitting height	0.7	5.2	12.9	1.2	0.1	-1.0	-3.6	-3.3	-2.3
Chronic bronchitis/emphysema (father)	0.3	0.4	0.8	-0.0	-0.1	-0.5	-0.9	-0.8	-0.8
High blood pressure (mother)	0.7	1.0	2.5	1.1	-0.1	0.8	1.0	1.6	0.7
Body mass index (BMI)	0.1	0.2	1.1	-0.4	1.0	0.4	-0.1	-0.1	-0.1
Impedance of leg (left)	0.4	1.8	7.1	-0.2	-2.7	-1.7	0.3	-0.7	-0.3
Leg predicted mass (left)	0.5	2.5	6.4	1.0	1.0	-0.3	-2.5	-1.9	-1.6
Trunk fat mass	0.4	1.6	4.2	-0.3	0.0	-0.9	-1.5	-2.1	-1.5
Waist circumference	0.7	2.6	5.5	-0.6	-0.0	-1.2	-2.1	-2.3	-2.0
Number of incorrect matches in round	0.6	0.9	2.3	-0.3	1.5	1.3	0.4	0.9	0.8
Past tobacco smoking	0.3	0.6	2.6	-0.4	1.6	0.6	-0.6	-0.0	0.5
Alcohol usually taken with meals	0.8	1.4	2.4	0.4	-0.6	-1.2	-1.5	-1.3	-1.5
Nervous feelings	0.3	0.6	1.0	-0.8	0.5	0.9	-1.0	-0.6	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.4	-0.5	-0.4	0.1	-0.7	0.1
Hearing difficulty/problems with background noise	0.1	0.1	0.3	-0.1	-0.3	0.3	-0.4	-0.2	-0.6
Hair/balding pattern: Pattern 2	1.0	1.3	4.4	-1.4	2.1	1.0	0.4	-0.1	0.7
Had menopause	0.3	0.4	1.0	0.1	-0.7	0.2	1.0	0.3	0.7
Had other major operations	0.8	0.9	2.4	0.3	0.5	1.5	0.4	1.0	1.4
Forced vital capacity (FVC)	1.0	4.0	9.7	3.1	-1.8	-1.2	-1.7	-1.9	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.9	19.5	4.4	0.8	0.6	0.6	1.3	0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.9	-0.6	0.9	0.5	-0.1	-0.6	0.3
Qualifications: None of the above	1.1	2.3	5.1	-2.3	1.8	1.6	-1.6	-0.6	-0.0
Financial difficulties in last 2 years	1.0	1.4	4.5	-0.7	2.1	0.7	-1.4	-0.2	-0.9
Mouth/teeth dental problems	0.1	0.2	0.5	-0.7	0.1	0.0	-0.7	-0.6	-0.3
Heart attack	0.5	0.7	1.2	-0.8	-1.1	-0.7	0.9	0.8	0.1
Allergy	0.2	0.4	1.0	-1.0	-0.6	-0.1	-0.7	-0.0	-0.6
Pain all over the body in last month	0.2	0.2	0.5	-0.1	-0.4	-0.5	-0.3	-0.7	-0.4
Diabetes (self-reported)	0.2	0.3	0.9	0.4	0.2	-0.8	-0.1	-0.3	-0.9
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.4	-0.6	-0.5	-0.2	0.6	-0.1	0.3
Medication: Ramipril	0.4	0.5	1.3	-0.2	-0.1	0.6	1.1	1.1	0.0
Medication: Simvastatin	0.8	1.1	2.8	-0.6	0.5	1.1	0.9	1.7	1.1
Fluid intelligence score	0.3	0.6	3.1	1.8	-0.1	-0.5	-0.4	-0.0	0.2
Illnesses of siblings	0.6	0.8	2.2	-0.3	0.9	1.1	-1.5	-0.6	-0.4
Neuroticism score	0.9	1.9	5.0	0.1	-0.5	-0.7	-1.5	-1.8	-2.2
Weight	0.4	2.0	4.5	0.3	0.5	-0.7	-2.1	-2.0	-1.6
Impedance of arm (right)	0.3	1.4	4.8	-0.9	-2.2	-1.3	0.3	-1.0	-0.5
Arm fat percentage (right)	0.1	0.3	1.0	-1.0	0.5	0.1	-0.0	-0.7	-0.2
Trunk fat-free mass	0.4	2.5	6.9	1.5	0.5	-0.3	-2.6	-1.9	-1.3
Hip circumference	2.0	8.5	18.9	-2.3	0.1	-2.1	-3.0	-4.4	-3.6
Time employed in main current job	1.0	1.2	2.2	0.4	-1.2	-1.2	-0.7	-1.2	-1.5
Alcohol intake versus 10 years previously	0.5	0.8	1.4	-0.5	-1.1	-0.6	-1.1	-0.1	-1.2
Father’s age at death	0.5	0.7	2.6	-1.0	-1.6	-0.3	0.4	-0.2	-0.0
Worrier / anxious feelings	0.6	1.2	2.4	-0.3	-1.4	-0.1	-0.9	-1.4	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.2	-1.0	-1.1	-1.0	0.8	-0.3	-0.2
Falls in the last year	0.2	0.3	0.5	-0.1	0.5	-0.6	-0.6	-0.7	-0.7
Hair/balding pattern: Pattern 3	0.4	0.6	2.0	-1.4	-0.9	-0.5	-0.0	0.6	0.1
Number of live births	0.2	0.3	0.8	-0.2	0.1	0.3	0.6	0.9	0.8
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	8.1	2.9	-1.1	-0.6	-1.9	-1.9	-1.4
Pulse rate	0.1	0.2	0.6	-0.6	-0.1	-0.3	0.4	-0.8	-0.1
Happiness	0.4	0.5	1.5	-1.2	0.4	0.7	0.5	0.4	0.7
Noisy workplace	0.3	0.4	1.0	-1.0	0.2	0.2	0.5	0.8	0.5
Qualifications: A levels/AS levels or equivalent	1.3	2.8	7.0	2.6	0.2	1.0	1.8	1.1	2.0
Serious illness, injury or assault of a close relative in last 2 years	3.5	4.1	9.9	3.1	-0.3	0.6	2.2	2.3	2.0
Mouth/teeth dental problems: Dentures	0.4	0.7	1.8	-0.5	0.5	0.5	1.1	0.8	1.3
Asthma	0.3	0.5	1.0	-0.8	-0.5	-0.9	0.2	-1.0	-0.6
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.8	7.5	-0.8	-2.3	-2.7	-1.4	-1.8	-2.0
Medication: Cholesterol lowering	0.2	0.2	0.6	-0.3	-0.3	0.6	0.4	0.8	0.2
Depression (self-reported)	0.9	1.1	3.8	-1.9	-1.2	-0.5	-0.2	-0.2	-0.9
Medication: Lansoprazole	0.7	0.8	3.8	-1.9	0.9	0.0	-0.3	-0.5	-0.3
Prospective memory result	1.0	1.2	1.9	-1.1	0.8	1.4	0.8	1.2	1.3
Lung cancer (father)	1.1	1.3	3.3	0.3	-1.8	-1.1	-1.0	-1.1	-1.1
Illnesses of mother	0.4	0.4	1.1	-0.8	1.1	0.3	-0.2	-0.6	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	9.6	3.1	-1.4	-0.6	-1.3	-1.2	-1.0
Pulse wave Arterial Stiffness index	0.3	0.4	1.2	1.1	0.4	0.8	0.1	0.4	0.5
Impedance of arm (left)	0.3	1.6	4.3	-0.9	-2.1	-1.6	0.2	-1.0	-0.6
Arm fat mass (right)	0.1	0.4	1.0	-0.0	0.7	-0.0	-0.7	-1.0	-0.5
Trunk predicted mass	0.4	2.4	6.5	1.5	0.5	-0.3	-2.5	-1.9	-1.3
Standing height	0.9	8.4	17.1	1.6	-1.1	-2.2	-4.1	-4.1	-2.9
Length of working week for main job	0.6	0.7	1.4	-0.8	-0.1	-0.2	1.2	1.0	1.0
Exposure to tobacco smoke at home	0.6	0.6	1.3	0.5	0.5	0.6	1.1	1.0	0.8
Breastfed as a baby	0.6	0.8	3.2	0.3	1.8	0.7	-0.8	-0.7	-0.2
Tense / ‘highly strung’	0.4	0.6	3.2	1.8	0.0	-0.2	0.3	0.7	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.7	-0.1	0.7	0.4	-0.2	-0.4
Hair/balding pattern: Pattern 4	0.4	0.9	2.1	1.4	-1.0	0.5	0.8	1.1	0.2
Birth weight of first child	0.3	0.5	1.7	-0.6	-0.1	-0.3	-1.3	-1.0	-0.4
Peak expiratory flow (PEF)	0.9	2.1	5.0	2.2	-0.9	-0.3	-1.4	-1.8	-1.2
Pulse wave reflection index	0.2	0.2	0.5	0.2	0.6	0.6	0.2	0.7	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	-0.5	1.0	0.3	-0.2	-0.2	-0.9
Loud music exposure frequency	0.8	0.8	1.6	-0.7	0.2	1.3	1.0	1.2	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.2	0.9	-1.1	0.4	0.3	0.1	-0.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.7	1.1	1.3	-0.1	1.1	0.4	0.6
Blood clot in the leg (DVT)	1.2	1.6	4.0	-0.3	2.0	1.9	-0.1	1.1	0.8
Medication: Paracetamol	1.7	2.9	3.9	0.1	-1.3	-2.0	-2.0	-1.9	-2.0
Headache pain in last month	0.6	1.1	3.7	1.9	0.5	-0.8	-0.9	-0.2	-1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.8	-0.8	0.4	-0.3	-0.9	-1.4	-0.3
Glaucoma (self-reported)	0.6	0.7	2.3	0.0	0.8	1.5	-0.9	0.2	0.8
Gout (self-reported)	0.6	0.9	2.2	-0.2	-1.2	-1.0	-0.4	-0.6	-1.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.2	-1.1	0.7	0.3	0.5	0.8	-0.0
Medication: Amlodipine	0.3	0.5	1.0	0.3	0.5	0.6	1.0	0.7	0.8
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.9	-0.3	0.7	0.9	-0.3	-0.3	0.3
Birth weight	0.3	0.6	2.7	-0.1	1.6	-0.3	-0.6	-0.6	0.5
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.2	-0.7	0.1	-0.8	-1.3	-0.8	-1.5
High blood pressure (siblings)	0.9	1.3	2.0	1.3	-1.0	-1.1	1.4	0.8	1.0
Forced vital capacity (FVC), Best measure	0.7	2.6	8.1	2.9	-1.5	-0.9	-1.2	-1.4	-1.0
Body fat percentage	0.2	0.8	2.1	-1.1	0.0	-0.6	-0.5	-1.4	-0.9
Leg fat percentage (right)	0.2	0.6	2.9	-1.7	0.2	0.2	-0.0	-0.7	0.0
Arm fat-free mass (right)	0.5	2.5	6.5	1.6	0.8	-0.3	-2.5	-1.8	-1.3
Exposure to tobacco smoke outside home	0.3	0.4	0.8	-0.1	-0.9	-0.7	0.9	0.3	0.0
Comparative body size at age 10	0.9	2.4	4.7	-0.0	0.0	2.2	1.6	1.9	1.9
Number of full brothers	0.6	0.7	3.0	0.7	0.3	0.2	1.7	0.4	0.7
Worry too long after embarrassment	1.0	1.7	3.5	-1.9	1.2	1.2	-1.3	-1.2	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.2	-0.4	0.2	0.3	1.5	1.0	1.0
Wheeze or whistling in the chest in last year	0.3	0.6	1.3	-1.1	-0.4	-1.0	-0.0	-0.2	-1.1
Number of children fathered	1.1	1.2	3.6	-1.1	0.8	1.9	0.8	0.7	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.3	-1.1	0.8	0.5	0.6	0.2	1.1
Age at first live birth	1.1	1.9	4.3	-0.6	-1.2	-1.4	-2.1	-1.6	-0.8
Pulse wave peak to peak time	0.5	0.6	1.1	-1.0	-0.5	-1.1	-0.4	-0.7	-0.8
Health satisfaction	0.2	0.3	1.1	-0.5	0.4	0.2	1.1	0.5	0.0
Shortness of breath walking on level ground	0.5	0.6	1.9	-0.8	-1.4	-0.6	0.9	0.2	-0.1
Qualifications: College or University degree	0.8	2.4	3.9	2.0	0.3	1.1	1.7	1.8	1.7
Eye problems/disorders: None of the above	0.3	0.3	0.6	0.6	-0.0	0.7	0.2	0.8	0.7
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	-0.8	0.4	-0.8	1.1	0.7	-0.5
Emphysema/chronic bronchitis	0.3	0.4	1.0	0.5	-0.1	-1.0	1.0	0.1	0.1
Medication for pain relief, constipation, heartburn	0.3	0.6	2.3	0.1	0.8	1.5	-0.2	0.2	0.5
Neck or shoulder pain in last month	0.4	0.6	1.3	0.3	-0.9	-0.5	-0.7	-0.8	-1.2
Medication: Blood pressure	0.9	1.5	2.9	1.4	-0.8	-0.0	1.7	1.7	0.7
Angina (self-reported)	0.6	0.8	2.4	0.4	0.5	1.6	0.1	0.9	1.1
Migraine (self-reported)	0.2	0.2	1.2	0.4	-1.1	-0.2	0.2	0.1	0.1
Medication: Ibuprofen	3.6	4.4	7.1	-1.0	-2.1	-2.7	-2.1	-2.2	-2.1
Medication: Allopurinol	0.4	0.6	2.2	-0.4	-0.1	-0.9	-0.4	-0.4	-1.5
Medication: Omeprazole	1.1	1.4	2.8	-0.4	-1.7	-1.4	-0.7	-1.1	-1.2
Medication: Seretide 50 evohaler	0.5	0.5	1.7	-1.3	0.5	-0.6	0.6	-0.8	-0.0
Mean time to correctly identify matches	1.5	2.8	11.4	-3.4	0.7	0.2	-1.9	-1.1	-0.7
Heart disease (mother)	1.0	1.2	3.2	-0.1	-1.8	-1.3	-0.7	-0.6	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.4	-0.3	0.5	0.6	-0.7	-0.5	-0.4
Whole body fat mass	0.4	1.6	4.3	-0.4	-0.0	-1.0	-1.5	-2.1	-1.5
Leg fat mass (right)	0.2	0.7	1.8	-0.8	0.3	-0.3	-1.1	-1.3	-0.8
Arm predicted mass (right)	0.6	2.8	7.3	1.6	1.0	-0.4	-2.7	-1.9	-1.5
Pulse rate, automated reading	0.2	0.7	3.3	-1.8	-0.4	-0.5	-0.3	-0.6	-0.2
Alcohol intake frequency.	0.1	0.3	1.2	-1.1	0.4	0.2	-0.2	0.4	0.0
Comparative height size at age 10	0.6	3.2	7.1	0.2	-0.9	-2.0	-2.0	-2.7	-1.8
Number of full sisters	1.0	1.3	2.6	-1.6	-0.2	0.4	1.4	1.6	0.5
Suffer from ‘nerves’	1.0	1.6	5.3	-0.3	-1.1	-0.6	-0.8	-1.3	-2.3
Overall health rating	0.5	1.0	2.6	-1.1	-1.0	-1.6	0.1	-0.2	-1.1
Chest pain or discomfort	1.0	1.4	6.0	-2.5	-1.0	-0.9	0.4	0.1	-0.7
Had major operations	1.0	1.2	1.9	0.8	1.4	1.0	0.8	1.4	1.0
Age at last live birth	0.5	0.8	3.0	-1.7	-0.4	0.3	-1.1	-0.0	0.4
Family relationship satisfaction	1.8	2.2	3.8	-0.7	1.5	1.6	1.6	1.9	1.4
Leg pain on walking	0.8	1.1	5.6	-2.4	0.1	0.5	0.1	-0.6	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.3	0.1	-1.2	-1.5	-0.6	-0.4	-1.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.7	0.5	-0.9	-1.3	0.2	-0.2	-0.8
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	4.0	-0.3	-2.0	-2.0	0.1	-1.4	-0.9
Medication: Aspirin	2.0	2.7	6.6	0.8	0.5	0.7	2.6	2.2	1.8
Supplements: Vitamin C	0.4	0.5	1.0	-0.0	-0.8	0.1	-0.8	-1.0	-0.8
Knee pain experienced in last month	0.4	0.6	2.1	-1.4	0.7	-1.0	-0.2	-0.0	-0.4
Hypertension (Self-reported)	1.6	4.6	11.4	1.7	0.6	1.2	3.4	2.3	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.4	-0.7	-0.6	-0.9	-0.5	-0.7	-1.2
Illnesses of father: Heart disease	0.2	0.3	0.6	0.8	-0.7	-0.3	0.1	0.7	0.3
Illnesses of siblings: Diabetes	1.1	1.3	2.9	1.7	-1.7	-1.1	0.9	-0.3	-0.5
Smoking status: Previous	0.6	0.8	3.8	0.6	-2.0	-0.4	0.3	0.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.9	7.9	0.2	-1.5	-1.1	-2.8	-2.3	-2.5
Whole body fat-free mass	0.5	2.8	7.6	1.4	0.7	-0.4	-2.8	-2.1	-1.6
Leg fat-free mass (right)	0.6	3.4	8.3	1.1	0.9	-0.7	-2.9	-2.3	-2.1
Arm fat percentage (left)	0.1	0.3	0.9	-0.9	0.4	-0.1	-0.1	-0.6	-0.4
Average weekly red wine intake	1.4	2.1	4.5	0.3	-0.9	-0.3	-2.1	-2.0	-1.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	0.8	0.5	0.1	-0.2	0.0	-0.4
Mood swings	0.8	1.4	3.1	-0.2	-1.3	-1.8	-0.1	-1.3	-1.4
Loneliness, isolation	0.3	0.4	0.6	0.5	0.8	0.5	0.8	0.2	0.7
Long-standing illness, disability or infirmity	1.0	1.6	2.2	-0.9	1.3	0.8	1.5	1.5	1.3
Ever had bowel cancer screening	0.3	0.4	0.9	-0.8	0.3	-0.3	-0.3	-1.0	-0.6
Diabetes diagnosed by doctor	0.2	0.3	1.2	0.3	-0.2	-0.2	-0.4	-0.2	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.6	5.4	-1.0	-0.7	-0.6	-2.3	-2.1	-2.0
Friendships satisfaction	0.7	0.9	1.4	-0.5	1.1	0.8	1.2	1.1	0.8
Qualifications: nursing, teaching	0.2	0.3	1.2	0.3	0.4	0.2	1.1	0.4	0.3
Commuting to job workplace: Walk	0.8	0.8	2.9	-0.3	1.2	1.7	0.6	0.1	0.5
Eye problems/disorders: Cataract	0.2	0.3	0.7	0.1	-0.1	-0.8	-0.3	-0.5	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	5.9	0.0	-2.4	-1.0	-1.3	-1.1	-1.3
Medication for cholesterol	0.6	0.9	1.8	-0.3	-0.5	-0.7	-1.3	-1.1	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.3	0.4	0.2	-0.6	1.5	0.8	0.4
Back pain experienced in last month	0.4	0.7	1.7	-0.8	-1.3	-0.9	-0.3	-0.8	-0.3
Mineral and other dietary supplements	0.6	0.7	1.3	-0.4	0.6	-1.1	-1.1	-0.5	-1.1
Breast cancer (self-reported)	0.1	0.1	0.3	0.2	0.1	-0.2	0.6	0.1	0.1
Asthma (self-reported)	0.3	0.6	1.2	-0.6	-1.0	-1.1	0.4	-0.8	-0.7
Osteoporosis (self-reported)	0.5	0.6	1.9	-0.7	-1.4	-0.6	0.8	0.2	-0.3
Osteoarthritis (self-reported)	0.3	0.4	1.4	1.2	-0.1	0.6	0.3	0.2	0.4
Medication: Aspirin	2.3	3.0	6.5	0.9	0.9	0.8	2.5	2.3	2.0
Medication: Gliclazide	0.3	0.3	1.2	-1.1	-0.4	-0.4	-0.0	-0.1	-0.6
Illnesses of father: None of the above (group 1)	1.1	1.4	2.9	-1.0	-0.7	-0.5	-1.6	-1.2	-1.7
Smoking status: Current	0.4	0.7	2.0	-1.1	1.4	0.5	-0.8	-0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	3.6	1.9	0.7	1.5	1.6	0.8	1.3
Whole body water mass	0.5	2.8	7.2	1.4	0.7	-0.4	-2.7	-2.1	-1.5
Leg predicted mass (right)	0.6	3.4	8.3	1.1	0.9	-0.7	-2.9	-2.3	-2.1
Arm fat mass (left)	0.1	0.4	1.0	-0.1	0.7	-0.1	-0.8	-1.0	-0.7
Number of self-reported non-cancer illnesses	0.3	0.5	1.9	-1.4	0.2	-0.0	0.8	0.4	0.2
Average weekly champagne plus white wine intake	0.4	0.5	1.4	0.5	1.2	0.5	0.3	0.4	0.9
Miserableness	0.7	1.2	1.9	-0.6	1.1	1.2	1.4	1.1	0.8
Guilty feelings	2.8	4.3	8.4	-0.8	1.0	-1.4	-2.9	-2.7	-2.5
Wears glasses or contact lenses	0.8	0.9	2.7	-1.1	0.8	-0.5	1.6	0.8	0.3
Ever taken oral contraceptive pill	0.7	0.7	2.4	-0.9	-1.5	-0.0	-0.5	-0.5	-0.9
Hearing aid user	0.5	0.6	2.4	1.5	-0.6	-0.4	0.2	0.7	-0.3
Mother’s age at death	0.6	0.7	2.2	-0.2	-0.4	0.4	-1.3	-1.5	-0.2
Financial situation satisfaction	0.0	0.0	0.0	0.0	-0.1	0.2	-0.2	0.0	-0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	2.5	-1.6	-0.3	0.6	0.5	-0.0	-0.1
Commuting to job workplace: Public transport	0.2	0.2	0.9	-0.3	0.3	0.1	-0.9	-0.6	0.0
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	-0.2	0.8	0.8	-0.4	0.1	0.6
Medication: Blood pressure	0.4	0.9	2.1	0.8	0.4	0.7	1.5	0.8	1.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	-0.5	-0.9	-0.4	-0.4	-1.0	-1.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	-0.4	-0.8	0.1	0.8	0.3	0.9
High cholesterol (Self-reported)	0.3	0.6	2.5	-1.6	0.4	0.4	0.5	0.4	0.3
Medication: Bendroflumethiazide	1.3	1.9	5.4	-0.5	0.1	0.7	2.3	1.3	1.9
Medication: Paracetamol	1.9	2.9	4.6	0.3	-1.5	-1.9	-2.1	-2.0	-1.8
Medication: Lisinopril	0.2	0.3	0.7	0.1	0.8	0.3	0.8	0.2	0.4
Medication: Atorvastatin	2.2	2.7	4.8	-1.6	-1.1	-1.1	-1.7	-2.2	-1.9
Illnesses of father: High blood pressure	1.2	1.5	4.5	0.9	0.6	0.1	2.1	1.2	1.3
Alcohol drinker status: Never	0.2	0.3	1.0	-0.5	-0.3	-1.0	0.3	0.1	-0.4
Ever smoked	0.7	1.3	2.1	0.3	-1.4	-1.4	-0.6	-1.3	-1.3
Basal metabolic rate	0.5	2.8	7.5	1.1	0.7	-0.4	-2.7	-2.2	-1.7
Leg fat percentage (left)	0.2	0.6	2.0	-1.4	0.2	-0.4	-0.4	-1.1	-0.6
Arm fat-free mass (left)	0.5	2.4	6.2	1.4	0.8	-0.3	-2.5	-1.9	-1.4
Number of operations (self-reported)	1.6	2.4	5.2	2.3	1.6	1.7	0.7	1.0	1.5
Average weekly beer plus cider intake	0.2	0.3	0.8	-0.6	-0.6	-0.6	-0.1	-0.9	-0.3
Irritability	2.1	3.6	5.8	1.8	-2.2	-2.4	-1.1	-1.2	-2.2
Risk taking	1.6	2.4	4.0	2.0	0.9	1.1	1.8	1.6	1.5
Ever had prostate specific antigen (PSA) test	0.9	1.1	1.9	1.0	0.5	1.2	1.4	0.5	1.3
Fractured/broken bones in last 5 years	0.3	0.4	1.1	0.5	-1.0	-0.5	0.2	0.8	-0.3
Age started oral contraceptive pill	0.3	0.4	1.7	-0.4	0.7	0.1	-0.4	-1.3	0.3
Diastolic blood pressure, automated reading	0.5	1.5	3.2	0.8	1.5	0.9	1.2	0.9	1.8
Ever depressed for a whole week	0.3	0.3	1.1	0.3	1.0	0.6	-0.3	-0.2	0.4
Unable to work because of sickness or disability	0.8	1.0	3.2	0.5	-1.8	-0.6	1.2	0.8	-0.1
Commuting to job workplace: Cycle	1.5	1.8	3.8	0.8	1.2	1.8	0.8	1.2	1.9
Myopia	0.4	0.5	1.5	0.5	0.5	-0.1	1.2	0.9	0.5
Vascular/heart problems diagnosed by doctor	1.3	3.7	8.5	-1.3	-0.8	-1.4	-2.9	-2.1	-2.2
Cholesterol lowering medication	0.2	0.3	0.6	-0.6	0.7	0.6	-0.5	-0.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.1	1.2	-1.8	-1.5	-0.1	-0.6	-0.8
Pain experienced in last month	0.1	0.2	0.8	0.4	-0.1	0.3	0.3	0.5	0.9
Supplements: Calcium	1.9	2.1	5.7	0.6	-2.4	-1.5	-0.6	-1.6	-1.2
Basal cell carcinoma (self-reported)	0.8	0.9	2.5	-1.1	-0.1	-1.0	-0.8	-1.6	-0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	-1.1	-0.8	-0.4	0.7	0.7	0.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.6	-0.4	1.7	1.9	0.0	1.2	0.6
Heart disease (siblings)	0.5	0.6	1.5	-0.6	-0.4	-0.5	1.2	1.0	0.5
Alcohol drinker status: Previous	0.6	0.6	1.7	1.3	-0.2	-0.5	1.2	0.5	0.2
Pack years of smoking	0.1	0.2	0.6	-0.8	0.4	-0.3	-0.2	-0.2	0.1
Impedance of whole body	0.3	1.7	5.6	-0.6	-2.4	-1.8	0.2	-1.0	-0.5
Leg fat mass (left)	0.3	1.1	2.6	-0.6	0.3	-0.6	-1.3	-1.6	-1.2
Arm predicted mass (left)	0.4	1.9	4.8	1.4	0.8	-0.2	-2.2	-1.7	-1.1