Hub : Genes

RP11-680F20.12

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.587 0.1280 2.9e-05 0.538 NA 0.496 NA 0.539 2.8e-16 NA 1.2e-14 NA 2.3e-16
2 GTEx Brain Cerebellum 0.672 0.0740 1.5e-08 0.548 NA 0.506 NA 0.531 3.8e-19 NA 3.3e-17 NA 2.3e-18
3 GTEx Brain Frontal Cortex BA9 0.246 0.0954 5.2e-03 0.295 NA 0.227 NA 0.260 1.6e-08 NA 1.1e-06 NA 1.4e-07
4 GTEx Esophagus Mucosa 0.101 0.0380 2.1e-03 0.028 NA 0.069 NA 0.034 5.2e-03 NA 2.2e-05 NA 2.4e-03
5 GTEx Esophagus Muscularis 0.140 0.0550 4.3e-03 0.060 NA 0.017 NA 0.038 1.7e-04 NA 3.1e-02 NA 2.2e-03
6 GTEx Spleen 0.381 0.1250 3.3e-03 0.001 NA -0.005 NA 0.005 3.0e-01 NA 4.5e-01 NA 2.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.5 0.8 2.7 -0.5 -0.6 -0.5 -1.7 -0.8 -0.7
Bipolar Disorder or Schizophrenia 1.7 4.2 7.2 -2.4 -2.5 -2.4 -2.7 -0.1 -0.5
Depressed Affect (Nagel 2018) 0.4 0.8 1.4 -1.0 -1.0 -1.0 -1.2 -0.7 0.2
Depression (Nagel 2018) 0.1 0.2 0.4 -0.5 -0.4 -0.4 -0.6 0.4 -0.0
Intelligence (Savage-Jansen 2018) 0.4 1.2 2.6 1.1 1.2 1.1 1.6 -0.3 -0.6
Neuroticism (Nagel 2018) 0.4 0.9 1.5 -1.1 -1.1 -1.1 -1.2 -0.7 0.1
Schizophrenia (2018) 2.1 4.4 7.2 -2.7 -2.7 -2.7 -2.1 0.6 -0.1
Schizophrenia vs Biploar Disorder 0.6 0.8 3.9 0.3 0.4 0.3 2.0 -0.1 0.5
Worry (Nagel 2018) 0.4 0.8 1.7 -0.5 -0.5 -0.4 -1.3 -1.1 1.1
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 -0.2 -0.2 -0.2 0.5 0.3 -0.3
Alzheimer’s Disease (in father) 1.6 1.7 2.8 1.6 1.7 1.7 -0.5 0.7 1.1
Alzheimer’s Disease (including proxy) 0.2 0.3 0.6 0.4 0.5 0.4 -0.4 0.8 0.6
Crohns Disease (2017) 0.7 1.6 5.6 -0.7 -0.7 -0.7 -2.4 -1.5 0.7
Irritable Bowel Disease (IBD) 0.7 1.6 6.0 0.2 0.1 0.1 -1.8 -2.5 -0.3
Ulcerative Colitis (UC) 0.7 1.4 3.0 1.1 1.0 1.0 -1.0 -1.7 -1.1
Major Depression (MDD) 1.1 1.3 4.3 -0.3 -0.4 -0.4 -0.2 -2.1 1.8
Reaction Time 0.5 1.0 3.0 0.2 0.3 0.2 -0.6 1.6 1.7
Verbal and Numeric Reasoning (VNR) 0.6 1.4 3.0 1.1 1.2 1.1 1.7 0.6 -1.1
Breast Cancer 0.6 1.5 5.6 -0.3 -0.2 -0.3 2.4 1.6 0.5
Ovarian Cancer 2.0 2.6 7.7 1.3 1.5 1.3 2.8 1.5 0.4
Prostate Cancer 0.3 0.4 0.7 -0.8 -0.8 -0.8 -0.6 -0.3 0.5
Age at First Birth 0.4 0.6 1.0 -1.0 -1.0 -1.0 -0.5 -0.2 -0.6
Bipolar Disorder (2011) 3.2 3.0 5.8 -1.9 -2.0 -2.0 -1.0 -0.4 -2.4
Body Mass Index (BMI) (2010) 0.6 0.8 1.2 0.9 0.9 0.8 -0.4 -1.1 1.1
Coronary Artery Disease (CAD) 1.2 1.4 4.0 0.9 0.9 0.8 -0.0 -1.5 2.0
Crohns Disease (2012) 1.3 2.1 6.6 -1.1 -1.1 -1.1 -2.6 -1.2 0.9
Mean Putamen Volume 0.4 0.5 1.1 -0.3 -0.3 -0.3 -0.9 -1.1 -0.9
Fasting Glucose 0.2 0.3 0.9 -0.3 -0.3 -0.4 -0.2 -0.5 -0.9
HbA1C 0.7 0.8 2.0 0.9 1.0 0.9 -1.4 0.2 -0.2
HDL Cholesterol 0.8 1.3 6.5 0.3 0.3 0.3 0.7 -0.6 -2.6
LDL Cholesterol 3.1 4.8 26.4 -0.9 -0.9 -0.9 -0.5 0.1 5.1
Lupus 0.3 0.4 1.2 -0.5 -0.4 -0.5 -0.6 -1.1 -0.5
Neuroticism (2016) 1.5 2.2 3.4 -1.7 -1.9 -1.8 -0.9 -1.7 0.1
Primary Biliary Cirrhosis 1.7 2.4 3.6 -1.8 -1.8 -1.8 -1.9 -0.3 1.0
Rheumatoid Arthritis 0.3 0.4 0.8 0.6 0.7 0.6 0.0 -0.4 -0.9
Schizophrenia (2014) 1.1 2.5 4.6 -2.1 -2.1 -2.1 -1.1 0.2 0.1
Triglycerides 0.9 1.4 5.0 0.4 0.3 0.3 -1.3 -1.2 2.2
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.7 -0.7 -0.7 -0.7 -0.8 0.1 0.0
Ulcerative Colitis 0.4 0.6 1.4 -0.6 -0.6 -0.6 -1.2 -0.9 -0.3
Blood Eosinophil Count 0.6 4.3 20.5 0.5 0.6 0.6 -2.0 0.7 -4.5
Blood Platelet Count 0.2 2.7 10.7 0.7 0.6 0.6 1.6 -1.2 3.3
Blood Red Count 0.2 1.5 2.9 1.6 1.7 1.7 -0.2 0.5 0.3
Blood White Count 0.2 1.7 3.3 1.8 1.8 1.8 0.4 -0.3 -0.5
Heel T-Score 0.6 4.4 12.1 -2.0 -1.8 -2.0 0.4 3.5 1.7
BMI 0.4 2.3 8.4 -0.9 -0.8 -0.9 -0.0 1.8 2.9
Height 0.8 16.3 91.2 0.7 0.4 0.6 -2.1 -9.6 1.0
Waist Hip Ratio (WHR) 0.3 1.3 3.1 -0.3 -0.3 -0.3 1.8 1.4 -1.6
Systolic Blood Pressure 0.5 2.7 3.5 1.9 1.8 1.9 1.3 -1.1 1.8
Smoking Status 0.1 0.2 0.3 -0.3 -0.3 -0.3 0.5 0.6 -0.4
Allergy or Eczema 0.3 0.9 1.4 1.1 1.2 1.1 0.5 0.8 -0.7
Cardiovascular Disease 0.5 1.7 8.9 0.3 0.1 0.3 0.4 -0.9 3.0
Hypothyroidism (self reported) 0.4 0.8 3.1 -0.3 -0.2 -0.3 1.0 1.8 -0.8
Respiratory disease 0.2 0.5 1.6 0.1 0.1 0.2 -0.3 1.2 1.2
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.0 -0.4 -0.3 -0.4 -0.6 0.6 1.0
Lung FEV1/FVC ratio 4.3 21.6 35.2 -4.9 -4.7 -4.8 -2.2 4.5 -5.9
Lung FVC 0.9 4.6 17.9 1.6 1.6 1.6 -1.2 -0.6 -4.2
Neuroticism 0.3 0.8 2.9 -0.1 -0.1 -0.1 -1.4 -1.7 0.3
Chronotype (morning person) 0.4 1.0 5.2 -0.3 -0.4 -0.3 0.1 -2.3 0.5
Hair Pigment 0.0 1.3 1.9 1.3 1.2 1.2 -0.2 -1.1 -1.4
Tanning 0.0 0.5 1.1 0.7 0.7 0.7 -1.0 -0.5 -0.2
Hand grip strength (left) 0.2 0.6 2.0 0.4 0.4 0.4 -0.6 -1.4 -0.9
Number of treatments/medications taken 0.4 0.6 0.8 -0.9 -0.9 -0.9 0.2 0.9 0.8
Average weekly spirits intake 1.0 1.3 2.1 -1.4 -1.4 -1.4 -1.0 0.7 0.3
Sensitivity / hurt feelings 0.4 0.7 2.5 0.4 0.4 0.4 0.5 -0.8 -1.6
Frequency of depressed mood in last 2 weeks 0.0 0.1 0.2 -0.0 0.1 -0.0 -0.2 0.4 0.4
Hearing difficulty/problems: Yes 1.6 2.4 4.2 -2.0 -2.0 -2.0 -0.2 1.2 -0.8
Relative age of first facial hair 0.4 0.8 3.3 0.5 0.4 0.4 0.8 -1.8 -0.7
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 2.8 -1.7 -1.6 -1.6 -0.9 1.4 -0.2
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.7 1.0 1.0 1.0 0.3 1.3 -0.1
Ever had hysterectomy (womb removed) 0.4 0.5 0.9 -0.9 -0.9 -0.9 0.2 0.4 -0.4
Systolic blood pressure, automated reading 1.6 4.6 7.0 2.4 2.4 2.4 2.6 -0.0 1.8
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 -0.3 -0.3 -0.3 -0.2 0.1 0.5
Angina 0.7 0.9 2.1 -0.7 -0.8 -0.8 -1.1 -0.7 1.4
Medication for hormone replacement therapy 0.4 0.5 1.1 0.5 0.5 0.5 1.1 0.7 0.7
Vitamin and mineral supplements 0.6 0.8 1.8 0.9 0.9 0.9 -0.0 0.6 1.4
Supplements: Zinc 1.3 1.4 2.6 -1.3 -1.3 -1.3 -1.6 -0.2 0.8
Medication: Co-codamol 1.0 1.2 2.2 -1.4 -1.5 -1.4 1.0 -0.1 -0.5
Medication: Metformin 0.6 0.8 1.2 -1.1 -1.1 -1.1 0.4 1.1 -0.0
Diabetes (father) 0.7 0.9 3.3 0.7 0.8 0.7 0.7 1.8 -0.2
Diabetes (mother) 1.4 1.8 6.3 0.8 0.8 0.8 -0.4 1.6 -2.5
Severe depression (siblings) 0.3 0.3 1.2 -0.5 -0.4 -0.5 0.5 -0.2 -1.1
Pack years adult smoking proportion 1.3 2.0 3.6 -1.5 -1.6 -1.6 0.4 -1.9 -0.9
Impedance of leg (right) 0.2 0.8 1.2 -1.0 -1.1 -1.1 1.1 -0.5 0.3
Leg fat-free mass (left) 0.2 0.9 2.2 0.7 0.7 0.7 -0.9 -1.5 0.9
Trunk fat percentage 0.6 2.4 4.2 -1.8 -1.8 -1.8 -0.1 -0.4 2.1
Hand grip strength (right) 0.2 0.4 1.8 0.4 0.3 0.3 0.2 -1.4 -0.6
Townsend deprivation index at recruitment 0.9 1.2 4.2 -0.2 -0.1 -0.1 0.5 2.0 1.7
Current tobacco smoking 0.6 1.0 1.7 -0.9 -0.8 -0.8 1.3 0.9 -1.1
Average weekly fortified wine intake 1.3 1.5 3.8 -1.0 -0.9 -1.0 -1.1 0.9 2.0
Maternal smoking around birth 0.4 0.5 1.2 -0.6 -0.8 -0.7 -1.1 -0.7 0.1
Fed-up feelings 1.2 2.2 3.6 -1.9 -1.9 -1.9 -0.3 -0.5 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.5 1.0 -0.7 -0.6 -0.7 -1.0 -0.7 -0.1
Relative age voice broke 0.9 1.4 3.9 -0.1 -0.1 -0.1 1.4 -2.0 -1.6
Taking other prescription medications 0.1 0.1 0.2 -0.4 -0.4 -0.4 -0.3 0.4 0.2
Age when periods started (menarche) 0.3 0.7 2.5 0.0 0.1 0.0 1.3 -1.6 0.3
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.3 -0.5 -0.5 -0.5 -0.2 0.5 0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 4.1 -2.0 -2.0 -2.0 -1.8 0.5 1.1
Tinnitus: Yes, but not now, but have in the past 0.0 0.1 0.3 0.1 0.1 0.1 0.1 0.0 0.5
Qualifications: CSEs or equivalent 0.9 1.2 2.1 1.4 1.3 1.5 -0.8 -0.1 0.9
Serious illness, injury or assault to yourself 0.3 0.3 1.1 0.1 0.1 0.1 -1.1 0.7 0.4
High blood pressure 0.5 1.3 6.9 0.5 0.6 0.6 0.3 -0.3 2.6
Hayfever, allergic rhinitis or eczema 0.3 0.6 0.9 0.9 0.9 1.0 0.7 0.7 0.1
Multivitamins +/- minerals 1.0 1.3 2.3 -1.5 -1.5 -1.5 -0.5 -0.3 -0.9
Stomach or abdominal pain in last month 2.2 2.7 5.0 -2.2 -2.2 -2.2 -0.2 -0.6 -1.0
Supplements: Glucosamine 0.3 0.4 1.8 -0.3 -0.3 -0.3 -1.3 -0.3 -0.2
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 1.9 1.2 1.2 1.2 0.4 -0.0 1.4
Medication: Atenolol 0.3 0.4 1.6 0.1 0.1 0.1 -0.1 -0.8 1.3
Medication: Levothyroxine sodium 0.4 0.6 0.9 -1.0 -1.0 -1.0 0.9 0.0 0.1
Sitting height 2.0 14.2 57.5 3.0 2.9 3.0 -0.6 -7.6 -0.7
Chronic bronchitis/emphysema (father) 0.2 0.2 1.3 -0.1 -0.2 -0.2 -0.1 -1.1 0.1
High blood pressure (mother) 0.5 0.6 1.2 -0.8 -0.8 -0.8 0.3 0.8 1.1
Body mass index (BMI) 0.3 1.2 1.7 -1.1 -1.1 -1.1 -0.6 1.3 1.3
Impedance of leg (left) 0.3 1.2 1.9 -1.3 -1.4 -1.3 1.1 -1.0 0.1
Leg predicted mass (left) 0.2 0.9 2.1 0.6 0.7 0.7 -0.9 -1.4 1.0
Trunk fat mass 0.5 2.3 3.9 -1.7 -1.7 -1.7 -0.6 -0.9 2.0
Waist circumference 0.2 0.6 1.3 -0.8 -0.7 -0.7 -0.1 0.8 1.1
Number of incorrect matches in round 0.4 0.6 1.5 0.7 0.7 0.6 1.0 -0.5 1.2
Past tobacco smoking 0.5 0.9 2.6 0.7 0.9 0.7 1.6 0.7 0.6
Alcohol usually taken with meals 0.1 0.2 0.6 0.0 0.1 0.1 0.7 0.3 -0.8
Nervous feelings 0.3 0.6 1.4 -0.8 -0.6 -0.7 0.8 -1.2 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.1 -1.1 -0.9 -1.0 0.1 -0.6 1.0
Hearing difficulty/problems with background noise 0.9 1.4 3.2 -1.1 -0.9 -1.0 -0.5 1.8 -1.3
Hair/balding pattern: Pattern 2 0.6 0.7 2.9 0.3 0.3 0.3 -0.8 0.6 -1.7
Had menopause 0.5 0.6 2.2 -0.2 -0.2 -0.2 -1.2 -1.5 -0.1
Had other major operations 0.0 0.0 0.1 0.1 0.1 0.2 -0.3 -0.0 0.1
Forced vital capacity (FVC) 1.1 4.2 13.1 0.4 0.4 0.4 -0.9 -3.3 -3.6
Heel bone mineral density (BMD) T-score, automated (right) 1.8 4.1 6.5 -2.5 -2.5 -2.5 -2.2 0.3 0.6
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 1.7 0.9 0.8 0.8 -0.9 -1.3 0.1
Qualifications: None of the above 0.3 0.6 0.9 0.9 0.9 0.9 -0.5 -0.7 -0.2
Financial difficulties in last 2 years 0.9 1.3 1.9 1.4 1.3 1.4 0.6 1.2 -0.6
Mouth/teeth dental problems 0.3 0.4 1.1 0.4 0.4 0.4 1.0 -0.1 -1.1
Heart attack 1.0 1.3 5.5 -0.3 -0.4 -0.3 -1.0 -1.0 2.3
Allergy 0.3 0.7 1.6 -0.7 -0.7 -0.8 -0.8 -0.3 -1.3
Pain all over the body in last month 0.6 0.7 2.1 -0.8 -0.7 -0.7 -0.6 0.3 -1.4
Diabetes (self-reported) 1.8 2.8 5.0 -2.2 -2.2 -2.2 0.5 1.2 0.2
Hayfever/allergic rhinitis (self-reported) 2.4 3.2 6.1 2.5 2.4 2.5 0.5 0.1 -0.8
Medication: Ramipril 1.2 1.5 6.2 0.6 0.6 0.6 1.3 -0.4 2.5
Medication: Simvastatin 2.2 3.2 4.6 -2.0 -1.9 -1.9 2.2 1.1 1.4
Fluid intelligence score 0.4 0.7 3.7 0.3 0.4 0.3 1.9 0.4 -0.5
Illnesses of siblings 0.7 1.0 3.3 -0.1 -0.1 -0.1 1.8 0.4 -1.6
Neuroticism score 0.2 0.5 2.0 -0.0 -0.0 -0.0 -0.9 -1.4 0.4
Weight 0.3 1.3 2.0 -1.0 -1.0 -1.0 -1.1 -1.4 1.4
Impedance of arm (right) 0.2 1.2 4.6 0.5 0.4 0.4 1.2 -2.1 0.6
Arm fat percentage (right) 0.3 1.2 2.8 -1.2 -1.2 -1.2 -0.2 -0.1 1.7
Trunk fat-free mass 0.2 1.2 5.2 0.5 0.5 0.5 -1.2 -2.3 -0.2
Hip circumference 0.3 1.2 4.6 -0.2 -0.2 -0.2 -1.0 -1.2 2.1
Time employed in main current job 1.0 1.2 2.7 0.9 0.9 0.9 1.7 0.3 1.4
Alcohol intake versus 10 years previously 0.3 0.5 1.1 -0.7 -0.7 -0.7 0.2 0.1 -1.1
Father’s age at death 1.9 2.5 9.8 -1.4 -1.2 -1.3 0.4 3.1 -0.3
Worrier / anxious feelings 0.5 1.0 1.9 1.0 0.9 1.0 -1.4 -1.1 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.5 -0.6 -0.6 -0.6 0.8 0.2 -1.2
Falls in the last year 0.5 0.7 2.0 0.7 0.6 0.7 -0.0 -1.4 -1.0
Hair/balding pattern: Pattern 3 0.0 0.1 0.2 0.0 0.0 0.0 -0.1 -0.5 -0.3
Number of live births 0.7 1.0 3.0 0.9 0.9 1.0 -0.1 0.5 -1.7
Forced expiratory volume in 1-second (FEV1) 1.3 4.2 19.9 -0.5 -0.5 -0.5 -1.5 -1.6 -4.5
Pulse rate 1.0 1.6 2.7 1.6 1.6 1.6 -1.3 -0.5 -0.0
Happiness 1.3 1.5 2.8 1.3 1.3 1.3 1.1 -0.6 1.7
Noisy workplace 2.6 3.2 5.6 -2.3 -2.4 -2.3 -1.6 -0.7 0.3
Qualifications: A levels/AS levels or equivalent 0.4 0.9 4.3 -0.3 -0.2 -0.3 -0.8 2.1 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.5 -0.5 -0.6 -0.6 -0.5 -0.7 0.7
Mouth/teeth dental problems: Dentures 0.4 0.7 2.8 0.1 0.1 0.1 -1.1 -0.7 -1.7
Asthma 0.9 1.7 8.2 -0.4 -0.4 -0.4 -0.9 0.9 2.9
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 2.7 0.5 0.5 0.6 -0.8 1.6 0.2
Medication: Cholesterol lowering 1.6 2.5 8.5 -1.5 -1.5 -1.5 -0.1 0.1 2.9
Depression (self-reported) 0.3 0.3 1.7 -0.3 -0.3 -0.3 -0.4 -1.3 0.2
Medication: Lansoprazole 1.5 1.7 4.7 1.3 1.3 1.4 -0.4 0.1 2.2
Prospective memory result 0.5 0.6 1.6 -0.8 -0.7 -0.8 -0.5 0.5 -1.3
Lung cancer (father) 0.4 0.5 1.1 -0.6 -0.7 -0.6 0.3 -1.1 -0.5
Illnesses of mother 0.7 0.9 1.8 -0.9 -1.0 -1.0 0.7 -1.3 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 17.7 -0.9 -0.8 -0.9 -1.0 -1.6 -4.2
Pulse wave Arterial Stiffness index 0.4 0.5 2.3 -0.0 0.0 0.0 0.8 -0.2 1.5
Impedance of arm (left) 0.2 1.1 2.8 0.4 0.3 0.3 1.5 -1.7 1.0
Arm fat mass (right) 0.3 1.1 3.7 -0.9 -0.9 -0.9 -0.5 -0.6 1.9
Trunk predicted mass 0.2 1.3 5.0 0.7 0.7 0.6 -1.2 -2.2 -0.2
Standing height 0.6 6.2 35.2 0.6 0.5 0.5 -0.9 -5.9 0.4
Length of working week for main job 0.2 0.3 1.2 0.3 0.3 0.3 1.1 -0.3 -0.2
Exposure to tobacco smoke at home 0.6 0.7 1.1 -0.9 -1.0 -1.0 -0.1 -1.1 0.6
Breastfed as a baby 0.4 0.5 2.5 0.3 0.3 0.3 -0.5 0.2 1.6
Tense / ‘highly strung’ 0.2 0.3 0.8 -0.4 -0.4 -0.3 -0.5 -0.8 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 6.2 -0.9 -0.8 -0.8 0.4 2.5 2.3
Hair/balding pattern: Pattern 4 2.6 6.3 12.5 -2.5 -2.4 -2.4 -1.4 3.5 2.2
Birth weight of first child 2.4 4.4 7.3 -2.7 -2.7 -2.7 -1.4 -1.3 -1.1
Peak expiratory flow (PEF) 1.7 3.8 12.5 -1.6 -1.5 -1.5 -1.9 0.0 -3.5
Pulse wave reflection index 0.7 0.8 1.6 -1.0 -1.0 -1.0 1.3 0.5 -0.6
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.1 0.4 0.4 0.4 -1.0 -0.8 1.0
Loud music exposure frequency 0.4 0.4 0.6 -0.7 -0.7 -0.7 0.2 -0.6 -0.8
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.9 -0.9 -0.9 -0.9 0.2 0.6 0.5
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 2.4 -1.4 -1.3 -1.4 0.8 1.6 0.0
Blood clot in the leg (DVT) 1.3 1.7 3.3 1.8 1.8 1.8 -0.5 0.4 -0.3
Medication: Paracetamol 0.4 0.7 0.9 0.9 0.9 0.9 0.9 0.8 -0.6
Headache pain in last month 0.1 0.2 1.1 0.2 0.1 0.2 0.5 1.1 -0.0
Medication for cholesterol, blood pressure or diabetes 1.8 3.0 4.4 2.1 2.0 2.1 0.9 0.0 -2.1
Glaucoma (self-reported) 0.4 0.5 1.7 -0.5 -0.4 -0.5 0.5 -1.3 -0.7
Gout (self-reported) 0.5 0.7 1.1 1.1 1.0 1.0 -0.6 -0.9 0.1
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.6 -0.4 -0.4 -0.4 0.7 0.8 -0.1
Medication: Amlodipine 1.1 1.5 2.0 -1.4 -1.4 -1.4 -1.0 -0.8 -1.4
Medication: Ventolin 100micrograms inhaler 0.3 0.4 2.0 -0.2 -0.2 -0.2 0.3 1.4 -0.4
Birth weight 0.1 0.2 0.4 -0.5 -0.4 -0.5 0.1 -0.6 0.1
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.6 0.6 0.5 0.6 -0.8 -0.0 -0.7
High blood pressure (siblings) 0.7 1.1 3.6 0.3 0.4 0.4 -0.4 1.5 1.9
Forced vital capacity (FVC), Best measure 0.7 2.5 7.9 0.0 0.0 0.1 -0.6 -2.6 -2.8
Body fat percentage 0.6 2.2 3.5 -1.8 -1.8 -1.8 -0.2 0.3 1.9
Leg fat percentage (right) 0.6 2.2 3.1 -1.8 -1.8 -1.7 -0.3 1.1 1.5
Arm fat-free mass (right) 0.1 0.6 1.9 -0.1 -0.1 -0.1 -1.2 -1.4 0.4
Exposure to tobacco smoke outside home 0.9 1.2 1.9 -1.2 -1.2 -1.2 0.4 1.4 0.7
Comparative body size at age 10 0.6 1.6 6.4 0.1 0.2 0.1 -0.3 1.7 2.5
Number of full brothers 1.5 1.9 3.6 -1.9 -1.9 -1.9 -0.2 -0.9 -0.4
Worry too long after embarrassment 0.6 1.0 2.4 -0.9 -0.9 -0.9 -1.0 -1.5 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.5 -1.2 -1.2 -1.2 0.2 -0.6 0.4
Wheeze or whistling in the chest in last year 0.6 1.1 3.8 -0.2 -0.1 -0.1 1.6 1.9 -0.2
Number of children fathered 0.5 0.5 2.9 0.2 0.2 0.2 1.7 -0.1 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 2.7 -0.2 -0.1 -0.2 -0.5 -0.4 -1.6
Age at first live birth 0.2 0.4 0.8 -0.7 -0.7 -0.7 -0.1 -0.1 0.9
Pulse wave peak to peak time 0.4 0.4 1.7 0.0 -0.0 -0.0 -0.9 -0.3 -1.3
Health satisfaction 0.9 1.2 3.5 -0.3 -0.3 -0.3 -1.9 -1.2 1.4
Shortness of breath walking on level ground 1.3 1.5 2.7 -1.1 -1.1 -1.1 -1.6 0.3 1.6
Qualifications: College or University degree 0.5 1.6 7.9 -0.7 -0.5 -0.6 0.9 2.8 0.2
Eye problems/disorders: None of the above 0.3 0.3 1.1 0.0 0.0 0.0 0.6 0.6 1.0
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.9 0.7 0.8 0.7 -0.6 -0.3 1.7
Emphysema/chronic bronchitis 1.6 1.9 2.8 -1.7 -1.6 -1.7 1.1 0.6 1.2
Medication for pain relief, constipation, heartburn 0.7 1.2 2.0 -1.1 -1.1 -1.1 -1.4 -1.2 -0.1
Neck or shoulder pain in last month 0.8 1.1 6.3 -0.0 -0.1 0.0 -2.5 -0.2 0.7
Medication: Blood pressure 1.0 1.8 3.3 -1.8 -1.8 -1.8 -0.5 0.6 0.5
Angina (self-reported) 0.7 0.9 2.3 -0.7 -0.7 -0.7 -1.2 -0.6 1.5
Migraine (self-reported) 0.1 0.2 0.4 0.4 0.2 0.4 0.4 -0.3 0.6
Medication: Ibuprofen 0.4 0.5 2.3 -0.1 -0.1 -0.1 -0.5 1.5 0.3
Medication: Allopurinol 0.2 0.2 1.0 0.3 0.2 0.3 -0.2 -1.0 0.0
Medication: Omeprazole 0.3 0.4 2.0 -0.4 -0.4 -0.4 -0.1 0.3 -1.4
Medication: Seretide 50 evohaler 1.0 1.1 2.9 1.1 1.1 1.1 -0.1 -1.7 0.5
Mean time to correctly identify matches 0.2 0.5 2.4 0.1 0.2 0.1 -0.3 1.6 0.4
Heart disease (mother) 0.1 0.1 0.2 0.4 0.3 0.4 0.5 0.3 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.7 3.2 5.3 2.2 2.2 2.3 1.1 0.8 1.4
Whole body fat mass 0.4 1.7 3.1 -1.4 -1.4 -1.4 -0.8 -0.6 1.8
Leg fat mass (right) 0.5 2.0 3.2 -1.7 -1.7 -1.6 -0.7 0.0 1.8
Arm predicted mass (right) 0.1 0.6 2.1 -0.0 -0.0 -0.0 -1.2 -1.5 0.5
Pulse rate, automated reading 0.1 0.3 1.7 0.1 0.1 0.1 -0.1 0.3 1.3
Alcohol intake frequency. 0.6 1.3 4.8 0.2 0.3 0.2 2.2 0.8 1.6
Comparative height size at age 10 0.3 1.6 6.5 -0.6 -0.7 -0.6 -1.3 -2.5 0.3
Number of full sisters 0.3 0.3 0.8 -0.5 -0.5 -0.5 0.5 0.9 -0.3
Suffer from ‘nerves’ 0.4 0.6 3.0 -0.3 -0.3 -0.3 -0.1 -0.7 1.7
Overall health rating 0.9 2.0 3.3 -1.8 -1.8 -1.8 -0.1 0.6 1.5
Chest pain or discomfort 1.2 1.8 2.4 -1.5 -1.5 -1.5 -1.1 0.6 1.6
Had major operations 0.3 0.4 0.6 -0.8 -0.7 -0.8 -0.2 -0.6 -0.2
Age at last live birth 0.6 0.8 2.0 -0.9 -0.9 -0.9 0.6 -1.4 0.5
Family relationship satisfaction 1.2 1.5 2.4 -1.5 -1.5 -1.5 -0.1 -0.4 1.3
Leg pain on walking 1.6 2.0 5.5 -1.1 -1.1 -1.1 -2.4 1.5 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.4 0.3 0.3 0.3 1.2 -0.6 0.7
Commuting to job workplace: Car/motor vehicle 0.5 0.6 2.9 0.4 0.4 0.5 0.4 -1.7 -0.1
Illness, injury, bereavement, stress in last 2 years 0.5 0.7 2.7 -0.4 -0.4 -0.4 1.6 0.9 -0.0
Medication: Aspirin 0.4 0.6 1.5 0.7 0.7 0.7 0.6 1.2 0.2
Supplements: Vitamin C 1.2 1.4 3.5 -0.9 -0.8 -0.8 1.1 1.2 -1.9
Knee pain experienced in last month 1.8 2.8 6.8 -1.5 -1.7 -1.5 -2.6 0.2 -1.5
Hypertension (Self-reported) 0.4 1.1 5.6 0.4 0.4 0.4 -0.1 -0.7 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.7 0.9 1.0 0.9 1.7 0.2 0.1
Illnesses of father: Heart disease 1.7 2.3 12.3 0.6 0.6 0.7 -0.4 0.4 3.5
Illnesses of siblings: Diabetes 0.1 0.1 0.4 -0.2 -0.2 -0.2 -0.6 -0.6 0.2
Smoking status: Previous 0.7 1.1 3.8 -0.6 -0.8 -0.6 -2.0 -1.0 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.7 -0.9 -0.9 -0.9 0.9 -1.7 0.8
Whole body fat-free mass 0.2 1.0 3.8 0.5 0.5 0.5 -1.1 -2.0 0.2
Leg fat-free mass (right) 0.2 0.9 2.8 0.7 0.7 0.7 -0.9 -1.7 0.7
Arm fat percentage (left) 0.4 1.4 3.6 -1.2 -1.3 -1.2 -0.1 0.3 1.9
Average weekly red wine intake 0.2 0.2 0.5 -0.6 -0.6 -0.5 -0.7 0.3 -0.0
Handedness (chirality/laterality): Left-handed 2.0 2.4 4.0 2.0 2.0 2.0 -0.6 -0.9 1.2
Mood swings 0.2 0.4 1.2 -0.3 -0.4 -0.3 0.2 -1.1 -1.0
Loneliness, isolation 0.7 1.0 2.3 -1.1 -1.0 -1.1 -1.5 0.3 0.2
Long-standing illness, disability or infirmity 0.2 0.4 1.6 -0.3 -0.2 -0.2 -0.6 1.3 -0.2
Ever had bowel cancer screening 1.1 1.2 2.3 1.1 1.3 1.2 0.3 1.5 -0.8
Diabetes diagnosed by doctor 1.2 1.9 3.2 -1.8 -1.7 -1.8 0.6 1.4 0.0
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 2.6 -1.6 -1.6 -1.6 -1.4 1.2 0.2
Friendships satisfaction 0.3 0.3 0.6 -0.2 -0.3 -0.2 0.7 -0.8 -0.8
Qualifications: nursing, teaching 0.3 0.4 0.7 -0.7 -0.7 -0.7 -0.4 0.5 0.9
Commuting to job workplace: Walk 2.5 2.7 5.1 -1.9 -1.9 -1.9 -2.3 0.4 -0.5
Eye problems/disorders: Cataract 0.1 0.1 0.5 0.2 0.3 0.2 -0.0 0.7 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.6 -0.8 -0.7 -0.7 -0.4 1.3 0.8
Medication for cholesterol 0.7 1.1 4.2 -0.5 -0.5 -0.6 -0.9 -0.6 -2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.5 0.5 0.5 0.5 0.7 -0.6 0.2
Back pain experienced in last month 0.1 0.2 0.3 -0.5 -0.5 -0.5 -0.0 0.4 0.5
Mineral and other dietary supplements 1.2 1.7 2.4 1.4 1.4 1.3 1.6 0.4 1.4
Breast cancer (self-reported) 0.8 1.0 1.3 -1.1 -1.0 -1.1 1.1 0.9 0.9
Asthma (self-reported) 0.8 1.7 8.0 -0.4 -0.4 -0.4 -1.0 0.8 2.8
Osteoporosis (self-reported) 0.9 1.1 2.3 -1.4 -1.5 -1.4 -0.7 -0.3 0.1
Osteoarthritis (self-reported) 1.8 2.3 5.0 -1.5 -1.5 -1.5 -1.5 2.2 0.0
Medication: Aspirin 0.3 0.4 1.1 0.2 0.2 0.2 0.8 1.1 0.6
Medication: Gliclazide 1.5 1.6 5.0 -1.2 -1.3 -1.2 -0.4 2.2 -0.4
Illnesses of father: None of the above (group 1) 0.9 1.2 6.8 -0.2 -0.2 -0.2 0.1 -0.2 -2.6
Smoking status: Current 0.8 1.2 3.5 -0.5 -0.4 -0.4 1.9 1.0 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.1 4.5 14.3 -2.1 -2.0 -2.1 0.0 -0.1 -3.8
Whole body water mass 0.2 1.0 4.2 0.5 0.5 0.5 -1.1 -2.1 0.2
Leg predicted mass (right) 0.2 0.9 2.8 0.7 0.7 0.7 -0.9 -1.7 0.7
Arm fat mass (left) 0.3 1.2 3.6 -1.0 -1.0 -1.0 -0.5 -0.3 1.9
Number of self-reported non-cancer illnesses 0.3 0.6 1.8 0.1 0.2 0.1 0.2 1.4 1.2
Average weekly champagne plus white wine intake 0.1 0.2 0.3 0.5 0.6 0.6 -0.0 0.2 0.5
Miserableness 0.3 0.5 2.4 0.1 0.1 0.1 -0.7 -1.5 -0.6
Guilty feelings 0.5 0.7 2.4 0.6 0.5 0.6 -0.6 -0.5 -1.5
Wears glasses or contact lenses 0.9 1.0 2.8 -0.4 -0.4 -0.4 -1.7 -1.5 0.5
Ever taken oral contraceptive pill 0.6 0.7 1.1 -0.9 -1.0 -0.9 -1.1 0.0 0.7
Hearing aid user 0.3 0.4 1.1 -0.4 -0.3 -0.4 -1.1 -0.6 0.4
Mother’s age at death 0.5 0.6 3.2 -0.2 -0.1 -0.2 -1.8 0.2 0.3
Financial situation satisfaction 0.3 0.4 1.3 0.3 0.3 0.3 1.1 -0.8 0.4
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.0 0.1 0.1 0.2 -0.8 0.2 -1.4
Commuting to job workplace: Public transport 1.6 1.9 3.8 1.5 1.5 1.5 0.6 2.0 0.8
Eye problems/disorders: Glaucoma 0.3 0.4 1.4 0.5 0.6 0.5 0.1 -1.2 -0.4
Medication: Blood pressure 0.5 1.0 1.9 1.1 1.1 1.1 0.7 -0.2 1.4
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.7 -0.3 -0.3 -0.3 -0.1 1.3 -1.3
Supplements: Fish oil (including cod liver oil) 1.7 2.2 6.4 -1.3 -1.2 -1.2 -1.5 0.2 -2.5
High cholesterol (Self-reported) 1.4 2.5 11.5 -0.3 -0.3 -0.3 1.6 -0.8 3.4
Medication: Bendroflumethiazide 0.5 0.8 1.4 0.8 0.9 0.9 1.0 1.2 0.4
Medication: Paracetamol 0.3 0.4 1.0 0.6 0.6 0.6 0.2 1.0 0.5
Medication: Lisinopril 0.4 0.6 1.7 0.3 0.3 0.3 -0.7 -1.3 -1.0
Medication: Atorvastatin 0.8 1.0 4.7 0.3 0.2 0.3 -0.7 0.4 2.2
Illnesses of father: High blood pressure 0.7 0.9 4.7 0.1 0.2 0.1 2.2 0.8 -0.4
Alcohol drinker status: Never 0.2 0.3 0.5 0.7 0.7 0.7 -0.3 -0.1 0.1
Ever smoked 0.2 0.4 0.9 -0.5 -0.7 -0.5 -1.0 0.1 -0.6
Basal metabolic rate 0.2 0.9 3.6 0.2 0.2 0.2 -1.1 -1.9 0.6
Leg fat percentage (left) 0.6 2.2 3.3 -1.8 -1.8 -1.8 -0.4 0.9 1.5
Arm fat-free mass (left) 0.2 1.0 4.1 0.2 0.2 0.2 -1.2 -2.0 0.1
Number of operations (self-reported) 0.8 1.3 1.6 -1.3 -1.3 -1.3 -1.1 -1.2 0.1
Average weekly beer plus cider intake 0.3 0.4 1.5 -0.1 -0.2 -0.2 0.8 -1.2 0.3
Irritability 0.4 0.6 1.1 -0.9 -0.8 -0.8 -0.6 0.3 -1.1
Risk taking 1.7 2.4 9.2 -0.6 -0.5 -0.6 3.0 1.7 -1.2
Ever had prostate specific antigen (PSA) test 3.0 3.4 5.7 -2.3 -2.4 -2.3 -2.0 -0.2 0.2
Fractured/broken bones in last 5 years 1.0 1.3 3.8 0.6 0.6 0.7 -1.6 -2.0 0.1
Age started oral contraceptive pill 1.0 1.2 2.4 1.5 1.6 1.5 0.2 -0.2 -0.4
Diastolic blood pressure, automated reading 0.9 2.7 8.0 1.3 1.3 1.3 1.7 -0.6 2.8
Ever depressed for a whole week 0.8 1.0 3.2 -0.8 -0.8 -0.9 -0.8 -1.8 -0.3
Unable to work because of sickness or disability 0.6 0.8 2.2 -0.6 -0.6 -0.6 -0.9 -0.7 1.5
Commuting to job workplace: Cycle 1.6 1.9 4.8 0.8 0.9 0.8 -1.2 2.2 -1.7
Myopia 1.2 1.7 3.8 1.2 1.3 1.1 2.0 1.0 1.1
Vascular/heart problems diagnosed by doctor 0.5 1.4 8.4 -0.2 -0.3 -0.3 0.1 0.0 -2.9
Cholesterol lowering medication 0.7 1.0 2.6 -0.8 -0.8 -0.7 0.6 1.6 1.0
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.7 -0.6 -0.5 -0.6 -0.0 0.9 -0.8
Pain experienced in last month 1.0 1.6 2.7 1.5 1.6 1.5 1.2 0.9 0.1
Supplements: Calcium 0.8 0.8 1.6 -1.2 -1.2 -1.2 -0.2 0.1 -0.7
Basal cell carcinoma (self-reported) 0.9 1.0 3.2 0.9 0.7 0.9 -1.8 0.8 -0.6
Heart attack/myocardial infarction (self-reported) 0.8 1.0 4.8 -0.1 -0.2 -0.1 -0.7 -0.9 2.2
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 1.8 1.3 1.3 1.3 -0.6 0.5 -0.3
Heart disease (siblings) 1.5 1.8 3.0 -1.2 -1.3 -1.3 -1.7 -0.8 1.6
Alcohol drinker status: Previous 0.8 0.9 1.7 -1.3 -1.2 -1.3 0.1 0.4 0.6
Pack years of smoking 1.3 1.9 4.4 -1.4 -1.4 -1.4 -0.1 -2.1 -1.2
Impedance of whole body 0.2 1.1 2.5 -0.6 -0.8 -0.7 1.6 -1.5 0.5
Leg fat mass (left) 0.5 1.9 3.1 -1.6 -1.6 -1.6 -0.8 -0.0 1.8
Arm predicted mass (left) 0.2 0.9 4.0 -0.0 -0.0 -0.0 -1.3 -2.0 0.1