Hub : Genes

RP11-6O2.4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1280	0.0350	7.4e-06	0.097	NA	0.093	NA	0.100	2.5e-08	NA	5.2e-08	NA	1.7e-08
2	GTEx	Adipose Visceral Omentum	0.2360	0.0610	1.0e-05	0.082	NA	0.126	NA	0.097	4.7e-05	NA	4.7e-07	NA	1.0e-05
3	GTEx	Adrenal Gland	0.2140	0.0784	4.6e-03	0.207	NA	0.143	NA	0.179	5.6e-08	NA	7.9e-06	NA	5.4e-07
4	GTEx	Artery Tibial	0.1015	0.0315	1.8e-04	0.040	NA	0.053	NA	0.039	4.2e-04	NA	5.1e-05	NA	4.9e-04
5	GTEx	Brain Cerebellum	0.2320	0.0750	2.0e-03	0.154	NA	0.076	NA	0.123	2.6e-05	NA	3.0e-03	NA	1.8e-04
6	GTEx	Brain Putamen basal ganglia	0.2780	0.1020	4.0e-03	0.006	NA	0.011	NA	-0.002	2.2e-01	NA	1.7e-01	NA	3.6e-01
7	GTEx	Breast Mammary Tissue	0.1100	0.0420	4.7e-03	0.009	NA	0.091	NA	0.057	1.0e-01	NA	2.0e-05	NA	7.1e-04
8	GTEx	Breast Mammary Tissue (Female)	0.0798	0.0765	1.9e-01	0.027	NA	0.005	NA	0.020	5.3e-02	NA	2.2e-01	NA	8.2e-02
9	GTEx	Cells Transformed fibroblasts	0.2160	0.0550	1.2e-07	0.127	NA	0.151	NA	0.158	8.9e-10	NA	1.9e-11	NA	6.3e-12
10	GTEx	Nerve Tibial	0.2038	0.0486	2.9e-07	0.112	NA	0.139	NA	0.143	2.7e-08	NA	4.8e-10	NA	2.5e-10
11	GTEx	Pancreas	0.2000	0.0690	3.4e-03	0.136	NA	0.180	NA	0.178	2.4e-06	NA	4.8e-08	NA	5.8e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.6	2.5	7.4	-0.8	-0.6	2.7	0.1	-0.4	-1.0	-2.3	-1.5	-1.4	-0.9	2.7
Bipolar Disorder or Schizophrenia	1.2	2.8	9.0	0.0	0.1	3.0	1.6	0.1	-0.2	-1.6	-0.6	-2.3	-2.0	2.8
Depressed Affect (Nagel 2018)	0.4	0.8	2.6	-1.1	-1.5	-0.6	-0.2	-0.7	-0.8	-0.6	-0.7	1.6	-0.1	-0.1
Depression (Nagel 2018)	0.6	1.0	3.7	-0.7	-1.6	0.5	-0.6	0.1	-0.5	-1.9	-1.4	0.8	-0.0	0.7
Intelligence (Savage-Jansen 2018)	0.4	1.3	5.3	-0.7	0.3	-1.0	-1.5	-0.0	-0.6	2.3	0.0	0.4	1.7	-1.5
Neuroticism (Nagel 2018)	0.3	0.8	3.3	-1.1	-1.8	-0.3	-0.7	-0.3	-0.8	-0.1	-1.2	1.1	-0.0	0.1
Schizophrenia (2018)	0.7	1.4	3.4	0.6	0.5	1.7	1.9	0.4	0.5	-0.3	0.4	-1.7	-1.8	1.4
Schizophrenia vs Biploar Disorder	0.3	0.5	1.4	1.2	0.7	-0.3	0.7	0.6	1.1	0.7	-0.2	-0.4	-0.2	-0.6
Worry (Nagel 2018)	0.3	0.6	1.5	-0.6	-1.2	-0.4	-1.2	-0.3	-0.7	0.8	-1.1	0.8	0.7	-0.3
Alzheimer’s Disease (in mother)	1.7	2.0	7.8	-0.9	-1.3	1.3	-0.6	-0.7	-1.4	0.1	-2.8	-2.0	-1.1	1.4
Alzheimer’s Disease (in father)	1.1	1.2	2.9	0.5	-0.3	-1.3	-1.2	0.4	0.1	1.6	0.6	1.0	1.7	-1.7
Alzheimer’s Disease (including proxy)	0.6	0.9	3.5	-0.2	-1.1	-0.1	-1.7	0.0	-0.9	1.1	-1.9	-0.3	0.6	-0.2
Crohns Disease (2017)	1.1	2.4	5.0	-1.9	-1.7	0.9	-1.8	-1.8	-2.2	-0.8	-2.0	-1.4	-0.2	0.7
Irritable Bowel Disease (IBD)	2.3	5.6	11.2	-3.1	-3.3	0.8	-2.7	-2.7	-3.3	-1.4	-3.2	-1.2	0.0	0.8
Ulcerative Colitis (UC)	2.0	3.8	8.1	-2.6	-2.8	0.1	-2.1	-2.2	-2.7	-1.1	-2.8	0.2	0.6	0.4
Major Depression (MDD)	0.3	0.4	1.1	0.6	0.1	0.8	0.0	1.0	0.5	-1.0	0.0	0.5	0.6	0.7
Reaction Time	0.3	0.6	2.0	1.3	0.5	0.8	0.4	1.4	1.1	-0.1	-0.0	0.3	0.2	0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	4.5	-0.0	0.9	-0.3	-1.1	0.4	0.0	2.1	-0.1	-0.1	1.1	-0.7
Breast Cancer	1.5	3.5	8.9	1.2	1.0	-3.0	-0.1	0.4	1.0	2.0	1.1	2.9	2.0	-3.0
Ovarian Cancer	2.1	2.8	7.6	-2.5	-1.8	-0.7	-2.8	-2.0	-2.2	-1.6	-1.4	0.0	0.8	-0.3
Prostate Cancer	0.8	1.2	4.3	-0.5	-1.4	-0.8	-2.1	0.0	-0.6	0.7	-0.0	1.4	1.4	-0.9
Age at First Birth	0.7	1.0	2.8	-1.6	-0.9	-0.7	-0.1	-1.7	-1.5	-0.3	-0.7	-0.6	-1.0	-0.6
Bipolar Disorder (2011)	1.6	1.5	4.1	-1.2	-1.3	1.0	-1.4	-0.9	-1.4	-2.0	-1.2	0.0	0.6	1.3
Body Mass Index (BMI) (2010)	0.6	0.8	1.8	-0.9	-1.1	0.8	-0.0	-0.9	-0.5	-0.5	-0.8	-0.8	-1.3	1.2
Coronary Artery Disease (CAD)	1.1	1.3	3.9	-1.0	-0.3	1.5	0.5	-0.5	-0.3	-2.0	0.4	-1.9	-1.1	1.4
Crohns Disease (2012)	0.3	0.4	1.3	-0.6	-0.9	0.3	-1.2	-0.6	-0.8	-0.3	-0.5	-0.5	0.5	-0.3
Mean Putamen Volume	0.2	0.2	0.8	-0.3	0.9	-0.4	0.1	-0.0	-0.5	0.0	0.4	0.3	0.2	-0.4
Fasting Glucose	0.4	0.5	3.0	-0.2	0.0	0.8	0.4	-0.2	-0.1	-0.8	-1.7	-0.7	-0.2	0.6
HbA1C	0.5	0.6	2.0	-0.1	-0.6	1.2	1.0	0.3	-0.1	-1.4	-0.2	-0.3	-0.5	1.0
HDL Cholesterol	1.4	2.3	5.7	-2.0	-1.5	-1.2	-2.4	-1.8	-2.0	-0.8	-1.3	0.5	1.1	-1.0
LDL Cholesterol	0.7	1.1	3.2	1.4	1.7	-0.1	-0.1	1.2	1.3	1.8	1.0	0.1	0.1	-0.5
Lupus	1.1	1.7	7.6	-1.2	-0.3	-1.2	-1.7	-1.3	-0.7	0.6	0.1	2.8	1.4	-0.7
Neuroticism (2016)	0.2	0.3	1.7	-0.0	-0.6	0.3	0.0	0.7	0.5	-1.3	-0.5	0.1	-0.6	0.5
Primary Biliary Cirrhosis	1.0	1.4	4.5	-0.7	-0.6	1.6	0.3	-0.7	-0.8	-1.5	-0.2	-2.1	-1.4	1.4
Rheumatoid Arthritis	0.2	0.2	1.3	0.1	0.2	0.4	0.2	0.3	-0.0	-1.1	-0.6	-0.3	-0.4	0.5
Schizophrenia (2014)	0.5	1.2	4.8	0.5	0.2	1.1	2.2	-0.2	0.3	1.0	0.4	-1.3	-1.8	0.9
Triglycerides	1.0	1.6	5.4	1.9	1.7	0.4	0.4	2.3	2.1	1.1	0.6	0.1	0.0	0.2
Type 2 Diabetes (T2D) (2012)	1.0	1.1	3.1	1.8	1.0	-0.6	1.0	1.7	1.2	0.6	-0.3	0.4	0.8	-0.9
Ulcerative Colitis	0.7	1.1	3.1	-1.3	-1.8	1.2	-0.9	-1.0	-1.2	-0.3	-1.1	-0.2	0.1	1.0
Blood Eosinophil Count	0.3	2.3	5.8	2.2	1.7	0.5	0.8	2.0	1.3	-0.2	2.0	0.9	2.4	0.1
Blood Platelet Count	0.0	0.5	2.9	1.0	0.4	-0.1	-0.1	0.5	0.9	1.7	-0.0	0.1	0.6	-0.1
Blood Red Count	0.2	1.6	8.6	0.0	-0.3	-1.2	-1.6	0.1	-0.5	-0.5	-0.5	0.4	2.9	-1.8
Blood White Count	0.1	0.5	2.8	0.6	-0.2	-0.5	1.7	-0.5	0.3	0.2	0.9	0.5	0.1	-0.8
Heel T-Score	0.3	2.3	5.6	1.6	0.9	-1.8	-0.9	1.9	1.8	0.7	0.6	1.3	1.8	-2.4
BMI	0.7	3.9	8.7	-3.0	-2.8	1.4	0.3	-2.6	-2.5	-1.6	-1.8	-0.4	-1.4	2.0
Height	0.2	3.5	10.6	1.8	0.8	0.2	3.2	1.5	2.0	3.1	1.5	-1.2	-2.0	-0.1
Waist Hip Ratio (WHR)	1.1	4.9	12.3	3.5	1.9	-0.4	1.5	3.4	3.1	2.2	2.9	0.4	0.8	-0.9
Systolic Blood Pressure	0.2	1.1	3.3	0.8	0.4	-0.8	1.6	-0.1	0.8	1.8	1.6	0.0	-1.1	-0.7
Smoking Status	0.9	2.2	7.0	1.0	-0.0	2.7	0.9	1.2	0.6	-1.9	0.7	-2.5	-0.2	1.7
Allergy or Eczema	0.3	0.7	2.2	1.1	0.3	-0.1	1.1	1.0	1.5	1.3	0.2	-0.2	-0.6	-0.5
Cardiovascular Disease	0.1	0.3	0.7	0.8	-0.5	-0.0	0.4	0.7	0.2	0.8	0.6	0.3	0.8	-0.2
Hypothyroidism (self reported)	0.1	0.2	0.8	-0.2	-0.1	0.2	0.6	0.1	-0.1	-0.9	-0.2	-0.7	-0.6	-0.1
Respiratory disease	0.3	0.6	1.9	0.2	-0.0	0.8	1.2	0.1	1.1	0.3	0.3	-0.5	-1.4	0.8
Type 2 Diabetes (T2D) (2018)	1.4	2.6	7.0	-1.8	-1.2	-1.8	-2.6	-1.3	-1.5	0.3	-1.6	1.9	1.5	-1.2
Lung FEV1/FVC ratio	3.4	17.4	64.2	5.7	3.7	-1.1	-1.0	5.5	3.6	3.0	3.3	2.6	8.0	-2.9
Lung FVC	0.7	3.5	12.8	2.7	3.6	1.2	1.1	2.9	1.9	-0.0	1.4	-0.9	0.7	0.3
Neuroticism	0.1	0.2	0.6	-0.0	-0.7	-0.3	-0.6	0.7	0.0	0.1	-0.7	0.6	0.4	-0.2
Chronotype (morning person)	0.3	0.7	2.2	-0.1	-0.8	0.6	1.5	-0.8	0.0	0.4	0.6	-1.4	-1.0	0.3
Hair Pigment	0.0	0.1	0.2	0.0	0.1	-0.2	-0.0	0.3	-0.0	-0.0	0.4	0.2	0.2	-0.4
Tanning	0.1	1.5	3.8	-1.3	-1.4	0.7	-0.5	-1.5	-1.6	-1.0	-1.9	-1.1	-0.5	1.0
Hand grip strength (left)	0.4	1.1	2.7	-0.8	-1.1	-1.1	-0.9	-0.6	-0.9	1.2	0.4	1.1	1.6	-1.1
Number of treatments/medications taken	1.2	2.1	5.7	-1.9	-1.8	0.3	1.4	-2.4	-1.4	0.7	-0.3	-0.0	-2.3	0.9
Average weekly spirits intake	0.3	0.4	1.2	0.3	-0.1	0.7	0.6	0.6	0.1	-0.4	-0.4	-1.1	-0.9	0.6
Sensitivity / hurt feelings	0.2	0.4	1.5	0.4	-0.1	1.1	0.4	1.2	0.7	-0.3	0.4	-0.4	-0.1	0.5
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.8	0.2	-0.6	0.6	-0.7	1.1	0.2	-1.4	-1.1	0.3	0.5	0.4
Hearing difficulty/problems: Yes	0.9	1.4	5.7	-0.1	0.4	1.2	2.2	-0.4	0.5	-0.5	0.4	-0.3	-2.4	1.6
Relative age of first facial hair	0.2	0.5	1.4	0.1	0.9	-0.4	-1.2	0.2	0.3	0.9	0.8	0.9	0.5	-0.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.8	-0.5	-0.6	0.5	1.5	-0.4	-0.1	0.9	-0.1	-0.6	-1.9	0.7
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.5	-0.7	-1.2	-0.3	-0.8	-0.3	-0.8	-0.1	-1.6	0.4	0.4	-0.5
Ever had hysterectomy (womb removed)	0.5	0.6	2.6	-0.8	-1.6	-1.1	-0.3	-1.0	-0.8	0.2	0.2	0.7	-0.1	-0.5
Systolic blood pressure, automated reading	0.4	1.1	3.5	0.6	0.0	0.1	1.9	-0.3	1.2	1.4	1.2	0.5	-1.6	0.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.2	0.1	0.8	1.5	0.4	0.1	0.1	-1.2	0.3	-1.5	0.1	1.3
Angina	0.6	0.8	3.2	0.4	0.3	1.0	1.2	0.4	0.8	-0.5	0.5	-0.9	-1.8	0.9
Medication for hormone replacement therapy	0.3	0.4	2.3	0.9	0.0	-0.3	0.3	0.2	0.4	1.5	-0.5	-0.5	-0.2	-0.6
Vitamin and mineral supplements	0.5	0.7	2.6	-0.3	-0.0	-1.3	0.1	-0.5	-0.2	0.1	0.9	1.4	1.6	-0.9
Supplements: Zinc	1.3	1.4	5.7	-0.7	-0.1	-1.7	0.2	-1.3	-0.6	2.4	0.8	1.2	-0.5	-1.4
Medication: Co-codamol	0.4	0.5	1.2	-0.6	-0.8	0.6	0.6	-0.9	-0.6	-0.5	-0.1	-0.7	-1.1	0.8
Medication: Metformin	1.0	1.4	4.3	-2.1	-1.4	0.1	-1.0	-1.3	-1.2	-1.7	-1.1	-0.0	-0.4	0.7
Diabetes (father)	0.4	0.5	2.3	-0.7	-0.6	0.1	-1.5	-0.3	-0.9	0.2	-0.6	0.3	1.1	0.1
Diabetes (mother)	0.7	0.9	2.2	-0.1	-0.7	0.8	1.2	-0.1	-0.1	-1.0	-1.3	-1.2	-1.5	0.8
Severe depression (siblings)	0.8	0.9	4.4	-0.6	-0.6	0.7	-0.7	0.0	-0.6	-2.1	-1.4	-0.9	-0.8	0.8
Pack years adult smoking proportion	0.5	0.8	2.3	-0.9	-1.5	-0.8	-1.1	-0.3	-0.7	-1.5	-0.7	0.2	0.2	-1.0
Impedance of leg (right)	0.1	0.6	2.2	1.5	0.8	-0.7	-0.1	1.4	0.8	-0.4	-0.4	-0.5	-0.1	-0.7
Leg fat-free mass (left)	0.1	0.4	1.4	-0.6	-0.2	1.0	1.2	-0.2	0.1	-0.3	0.4	-0.1	-0.5	0.8
Trunk fat percentage	1.5	5.9	15.6	-4.0	-2.5	0.9	-0.1	-3.8	-3.1	-1.6	-2.4	0.1	-2.4	2.1
Hand grip strength (right)	0.7	1.8	4.3	-1.3	-2.0	-0.9	-2.0	-1.1	-1.8	0.4	-0.1	0.4	2.1	-0.8
Townsend deprivation index at recruitment	0.3	0.4	1.1	0.6	-0.4	0.1	1.0	0.4	0.6	-0.3	0.9	-0.8	-1.0	-0.0
Current tobacco smoking	0.7	1.2	2.8	0.5	-0.0	1.3	1.5	0.3	0.5	-1.7	0.7	-1.5	-1.3	1.2
Average weekly fortified wine intake	3.2	3.7	8.4	2.6	2.6	-0.7	1.7	2.9	2.6	0.9	2.2	1.4	0.7	-0.8
Maternal smoking around birth	1.9	2.8	7.7	-2.6	-2.8	-0.3	-0.1	-2.4	-2.3	-0.6	-1.3	-0.8	-1.6	0.1
Fed-up feelings	0.5	1.0	3.6	-1.4	-1.9	-0.2	0.0	-1.1	-1.1	-0.8	-1.4	0.0	-0.4	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	0.1	-0.7	0.2	0.6	0.7	0.2	-0.6	-0.7	0.7	-0.1	0.6
Relative age voice broke	0.9	1.3	3.8	0.5	-0.2	-1.0	-2.0	0.7	0.3	1.1	0.3	1.8	1.7	-1.0
Taking other prescription medications	0.4	0.6	2.6	-0.5	-1.0	0.2	1.4	-0.5	-0.2	0.1	-0.8	-0.6	-1.6	0.2
Age when periods started (menarche)	0.1	0.2	1.0	0.3	0.9	-0.3	-0.5	0.1	0.1	0.0	1.0	-0.3	0.1	-0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.9	0.6	-0.1	0.4	-0.9	0.4	0.4	0.0	0.6	0.0	1.0	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	4.4	-1.6	-1.8	-0.9	-2.1	-1.0	-1.5	0.6	-1.8	-0.2	0.6	-1.0
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.3	1.5	1.8	-1.0	0.8	1.3	1.6	1.4	1.4	0.2	0.9	-1.4
Qualifications: CSEs or equivalent	0.4	0.5	1.6	-0.2	0.5	-0.8	-0.5	-0.1	0.3	1.3	0.2	1.2	0.3	-0.9
Serious illness, injury or assault to yourself	0.9	1.1	3.4	-1.3	-1.8	-0.1	-0.2	-1.2	-1.1	-0.6	-0.9	-0.4	-1.6	0.3
High blood pressure	0.1	0.3	0.6	0.7	0.1	-0.5	0.4	0.3	0.4	0.6	0.8	0.5	-0.4	-0.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	4.8	0.8	0.3	-0.6	0.9	0.4	1.3	2.2	-0.2	0.3	-0.6	-0.7
Multivitamins +/- minerals	1.0	1.3	4.4	-1.0	-1.3	0.6	-1.7	-0.6	-1.1	0.1	-2.1	-1.4	-0.3	0.3
Stomach or abdominal pain in last month	1.2	1.4	5.5	0.8	-0.2	-1.8	-0.2	0.8	0.7	0.7	0.6	2.4	1.1	-1.8
Supplements: Glucosamine	1.2	1.6	3.8	0.4	0.6	1.9	1.3	0.5	1.0	0.9	0.2	-2.0	-1.9	1.3
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.4	1.4	1.3	-0.5	1.8	1.1	1.3	1.4	1.2	-0.3	-0.6	-0.8
Medication: Atenolol	0.5	0.6	1.2	-1.1	-1.0	0.6	-0.4	-1.0	-1.0	0.2	-0.8	-0.4	-0.7	0.8
Medication: Levothyroxine sodium	0.3	0.4	2.0	-0.5	-0.1	0.6	1.0	-0.6	-0.5	-0.4	-0.1	-0.2	-1.4	0.7
Sitting height	1.3	9.2	20.5	3.9	4.1	0.4	4.5	3.4	4.2	2.3	3.7	0.4	-0.3	-0.4
Chronic bronchitis/emphysema (father)	1.1	1.2	2.8	-1.3	-1.3	-1.1	-1.1	-1.4	-1.4	-0.6	-1.7	-0.1	-0.2	-0.9
High blood pressure (mother)	0.9	1.3	2.9	-1.3	-1.2	-1.2	-1.6	-1.2	-1.1	-0.2	-0.8	1.7	0.8	-0.4
Body mass index (BMI)	1.3	5.4	14.1	-3.8	-3.2	1.1	-0.6	-3.2	-3.0	-2.0	-2.3	-0.2	-1.4	1.8
Impedance of leg (left)	0.1	0.3	1.1	1.0	0.3	-0.8	-0.3	0.7	0.3	-0.2	-0.1	-0.2	0.1	-0.7
Leg predicted mass (left)	0.1	0.3	1.4	-0.5	-0.1	0.9	1.2	-0.2	0.2	-0.2	0.4	0.0	-0.4	0.8
Trunk fat mass	1.0	4.4	11.4	-3.4	-2.3	1.1	0.5	-3.1	-2.4	-1.3	-2.0	-0.2	-2.4	1.9
Waist circumference	0.5	1.7	4.0	-1.4	-1.3	1.5	1.3	-0.8	-0.7	-1.2	-0.8	-1.1	-2.0	1.6
Number of incorrect matches in round	0.9	1.5	7.8	0.3	-0.1	0.8	2.1	0.2	1.0	-0.6	-0.1	-0.6	-2.8	1.2
Past tobacco smoking	0.2	0.4	1.5	-0.2	0.1	-1.2	-0.1	-0.5	-0.1	0.9	-0.2	0.9	0.1	-0.9
Alcohol usually taken with meals	0.1	0.2	0.9	0.4	0.9	-0.2	0.6	0.2	0.3	-0.0	-0.1	0.6	-0.8	0.2
Nervous feelings	0.5	0.9	4.1	0.4	0.5	-0.2	-1.7	0.9	0.2	0.2	-0.7	0.9	2.0	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	4.1	-0.7	-0.7	0.5	0.1	-0.2	-0.2	-2.0	-0.7	1.3	-0.1	1.0
Hearing difficulty/problems with background noise	2.0	3.2	10.6	1.8	1.0	1.1	3.3	1.9	2.5	0.9	1.8	-0.3	-2.0	1.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.5	0.4	0.1	1.1	-0.0	0.3	0.3	-0.2	0.3	-1.1	0.0	1.2
Had menopause	0.4	0.5	2.7	-0.9	0.1	-0.4	-1.6	-0.6	-0.7	-0.4	-0.4	0.1	-0.4	-0.5
Had other major operations	1.8	2.2	4.3	-1.7	-1.8	0.0	-1.4	-2.1	-2.1	-1.7	-1.7	1.3	0.3	0.6
Forced vital capacity (FVC)	2.1	8.2	19.1	4.4	3.9	0.3	2.6	4.3	3.9	2.1	2.9	-0.9	1.0	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	6.6	-1.3	-1.6	-0.8	-2.6	-0.6	-1.4	0.0	-2.2	-0.1	1.0	-1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.2	1.1	0.4	-0.6	0.4	1.1	1.0	0.6	0.0	1.0	0.4	-0.8
Qualifications: None of the above	0.7	1.5	4.3	-1.2	-1.3	1.2	0.6	-1.3	-1.5	-2.1	-0.8	-0.7	-0.5	1.3
Financial difficulties in last 2 years	0.7	0.9	2.4	1.5	0.9	-0.2	1.3	1.3	1.5	0.3	0.8	0.8	-0.3	-0.4
Mouth/teeth dental problems	0.4	0.6	2.2	1.1	0.4	0.7	-0.4	1.5	1.1	0.1	0.8	-0.9	0.6	0.1
Heart attack	1.0	1.2	3.2	-1.4	-1.8	0.2	-0.4	-1.2	-1.6	-1.3	-1.0	-0.2	-1.1	0.5
Allergy	0.5	1.2	5.8	-0.9	-0.4	-0.1	-1.5	-0.7	-1.8	-2.4	-0.2	-0.3	0.8	-0.2
Pain all over the body in last month	0.2	0.2	0.6	-0.0	0.1	-0.5	0.8	0.3	0.5	-0.3	0.5	0.8	-0.5	-0.3
Diabetes (self-reported)	1.9	3.0	6.3	-2.5	-2.0	-1.3	-2.5	-1.8	-2.1	-0.4	-1.9	1.7	0.9	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.8	-0.0	0.3	0.5	0.2	-0.4	-0.2	-0.4	-0.0	0.3	0.3	0.9
Medication: Ramipril	0.4	0.5	1.7	-0.6	-1.3	-0.9	-0.2	-0.6	-0.6	1.0	0.2	1.0	0.0	-0.4
Medication: Simvastatin	0.2	0.3	1.7	-0.1	-0.7	-0.3	0.6	-0.4	-0.2	1.3	-0.1	-0.6	-0.1	-0.4
Fluid intelligence score	0.5	1.0	3.0	0.3	1.2	-0.5	-1.1	0.8	0.5	1.7	0.3	-0.2	1.5	-1.3
Illnesses of siblings	2.1	2.9	6.1	2.0	1.0	-1.4	0.7	1.9	1.8	1.6	2.5	1.7	1.6	-1.8
Neuroticism score	0.3	0.7	2.1	-0.8	-1.5	-0.3	-0.6	-0.4	-0.6	-0.1	-1.5	1.2	0.3	0.1
Weight	0.3	1.5	3.8	-1.9	-1.6	1.1	0.9	-1.5	-1.0	-0.9	-0.8	-0.3	-1.4	1.4
Impedance of arm (right)	0.4	1.9	8.2	1.6	2.9	-1.2	0.9	0.9	1.5	1.4	1.1	0.7	-0.3	-0.9
Arm fat percentage (right)	1.3	5.3	14.0	-3.7	-2.5	1.2	0.1	-3.3	-2.7	-1.6	-2.2	-0.4	-2.4	2.2
Trunk fat-free mass	0.2	1.3	3.3	1.2	0.3	1.1	1.8	1.7	1.7	0.5	1.3	-0.7	-0.2	0.2
Hip circumference	0.5	2.0	5.2	-1.3	-0.5	1.7	1.9	-1.0	-0.5	-1.2	-1.1	-1.0	-2.3	1.8
Time employed in main current job	0.4	0.5	2.2	0.4	0.4	0.1	1.5	0.4	0.9	-0.2	0.0	-0.7	-1.1	-0.0
Alcohol intake versus 10 years previously	1.8	2.7	7.1	-0.8	-0.1	-2.2	-2.6	-0.3	-1.3	0.7	-1.2	1.0	2.7	-2.4
Father’s age at death	0.9	1.2	3.5	0.3	0.7	-1.6	1.1	0.3	0.8	1.3	1.4	0.6	0.1	-1.9
Worrier / anxious feelings	0.4	0.7	2.2	-1.0	-1.5	0.1	-1.5	-0.6	-0.6	0.5	-0.9	0.8	0.2	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	2.2	-0.7	-1.5	0.2	0.2	-0.4	-0.4	-1.2	-0.7	0.6	-0.4	0.7
Falls in the last year	0.4	0.6	2.5	-0.2	-1.2	0.6	-0.2	0.1	-0.1	-0.9	-1.6	-0.5	-0.8	0.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.2	0.5	-0.8	0.3	-0.1	0.1	0.9	0.6	0.7	0.1	-0.5
Number of live births	1.5	2.2	10.2	0.4	-0.9	3.2	0.6	0.6	0.3	-0.7	-0.9	-1.9	-0.5	2.5
Forced expiratory volume in 1-second (FEV1)	3.0	10.1	24.4	4.9	4.2	-0.1	1.5	4.9	4.0	2.4	2.9	-0.1	3.2	-1.5
Pulse rate	2.0	3.4	6.2	-2.3	-2.4	1.4	-2.3	-1.8	-2.5	-1.8	-1.7	-0.3	0.1	2.0
Happiness	0.3	0.4	1.9	0.6	0.5	0.4	-0.7	1.4	0.6	-0.1	-0.7	-0.4	0.2	-0.3
Noisy workplace	0.5	0.7	1.6	1.3	0.2	-0.2	-0.0	0.9	0.7	0.9	1.3	0.3	1.3	0.0
Qualifications: A levels/AS levels or equivalent	0.8	1.8	5.8	1.4	1.5	-0.8	-0.5	1.6	1.4	2.4	1.0	0.5	1.1	-1.3
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	4.9	-2.2	-1.8	-0.5	-0.8	-1.7	-2.0	-0.6	-1.4	0.4	-0.6	0.2
Mouth/teeth dental problems: Dentures	0.4	0.7	2.5	-0.7	0.2	-1.2	0.2	-1.0	-0.7	1.6	0.2	1.3	0.2	-0.7
Asthma	0.6	1.3	3.8	0.3	-0.3	1.7	1.4	0.1	1.0	-0.5	0.3	-1.1	-1.9	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.7	-0.8	-0.8	1.1	1.3	-0.9	-0.3	-0.3	-0.1	-0.2	-0.5	1.3
Medication: Cholesterol lowering	0.8	1.2	3.7	-1.2	-1.3	-1.0	-0.4	-1.6	-0.7	1.6	0.3	1.9	0.2	-0.3
Depression (self-reported)	0.7	0.9	2.1	-1.1	-1.4	0.9	-1.0	-0.6	-1.0	-0.7	-1.2	0.1	0.0	1.1
Medication: Lansoprazole	1.6	1.8	5.6	-2.3	-1.7	-0.5	-0.6	-2.4	-1.9	-0.7	-0.0	0.6	-0.7	0.3
Prospective memory result	0.8	0.9	3.6	1.1	1.3	0.5	1.9	1.0	1.1	-0.6	0.7	-0.3	-0.5	0.2
Lung cancer (father)	0.2	0.2	1.3	0.1	0.2	0.3	-0.3	0.3	0.0	-0.7	-1.1	0.6	-0.4	0.3
Illnesses of mother	0.9	1.2	3.2	1.7	1.1	0.7	0.3	1.8	1.3	0.7	0.6	-1.4	0.8	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	3.5	11.2	25.7	5.1	3.8	-0.8	1.4	4.9	3.9	3.3	3.1	-0.0	3.8	-2.5
Pulse wave Arterial Stiffness index	1.8	2.1	6.8	1.3	1.4	0.6	2.6	0.7	1.5	0.5	2.3	-0.4	-1.9	0.8
Impedance of arm (left)	0.4	1.7	8.2	1.6	2.9	-0.9	0.8	1.0	1.4	1.4	0.9	0.7	-0.1	-0.5
Arm fat mass (right)	1.0	3.9	9.9	-3.2	-2.2	1.4	0.4	-2.7	-2.2	-1.6	-1.8	-0.5	-2.0	2.0
Trunk predicted mass	0.2	1.2	2.9	1.2	0.3	1.0	1.7	1.6	1.7	0.6	1.3	-0.7	-0.1	0.1
Standing height	0.7	7.3	16.0	3.6	3.4	0.4	3.5	3.4	4.0	1.9	3.4	-0.2	-0.5	-0.3
Length of working week for main job	0.8	0.9	2.3	1.3	0.1	-0.1	1.2	0.5	1.2	1.5	1.5	0.0	0.2	-0.1
Exposure to tobacco smoke at home	0.4	0.4	1.5	0.9	0.5	0.1	0.4	1.1	1.2	0.1	0.0	-0.7	0.0	-0.4
Breastfed as a baby	1.7	2.0	7.4	-1.6	-1.5	-0.5	-2.7	-1.3	-2.0	0.1	-1.8	-0.7	0.5	-0.3
Tense / ‘highly strung’	0.2	0.4	2.4	-0.3	-0.8	-0.5	-0.7	0.3	0.1	0.1	-1.5	0.5	0.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	3.3	1.7	1.1	1.1	1.8	1.8	1.7	0.1	1.4	0.1	-0.5	1.0
Hair/balding pattern: Pattern 4	0.8	2.0	4.9	-2.2	-2.0	-1.2	-1.4	-2.1	-2.2	-0.2	-0.7	0.4	-0.2	-0.5
Birth weight of first child	1.0	1.9	5.5	1.5	2.1	0.9	0.5	1.8	1.3	1.3	2.4	-0.2	1.1	0.5
Peak expiratory flow (PEF)	1.0	2.2	6.9	2.1	2.1	0.0	0.3	2.0	1.4	1.0	1.0	0.7	2.6	-0.4
Pulse wave reflection index	2.0	2.5	9.3	2.0	1.3	-0.4	3.0	1.1	2.2	1.1	1.4	-0.9	-1.4	-0.7
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.7	0.5	0.1	-0.2	0.2	0.4	0.2	0.1	0.4	1.0	1.3	-0.1
Loud music exposure frequency	0.4	0.4	1.2	1.1	0.6	0.1	0.2	0.8	1.0	-0.1	-0.7	-0.5	0.5	-0.2
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.8	1.1	1.7	-1.2	-0.9	1.5	1.3	1.6	2.0	1.4	1.4	-1.6
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.9	1.5	1.1	0.4	1.7	1.3	1.7	0.1	1.0	-0.6	-0.6	-0.0
Blood clot in the leg (DVT)	0.5	0.6	1.8	-0.0	0.4	0.7	1.4	-0.3	0.6	0.6	1.1	0.2	-0.9	1.2
Medication: Paracetamol	0.7	1.1	2.9	-1.3	-1.5	0.2	-0.0	-1.7	-1.3	-0.3	-1.3	-0.9	-0.5	0.7
Headache pain in last month	1.3	2.3	6.5	-0.7	-1.3	2.4	0.2	-0.5	-0.9	-1.6	-2.5	-1.1	-0.3	2.5
Medication for cholesterol, blood pressure or diabetes	1.7	2.7	7.3	2.5	2.7	0.8	0.6	2.7	2.1	-1.2	0.5	-1.1	1.0	0.0
Glaucoma (self-reported)	1.3	1.5	4.2	-0.6	-2.0	1.0	-0.4	-0.4	-0.6	-1.6	-2.0	-1.3	-0.7	1.4
Gout (self-reported)	1.0	1.3	3.9	0.6	-0.3	-1.3	-0.4	0.7	1.1	1.5	1.2	2.0	1.1	-1.4
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.3	-0.2	-0.1	-0.0	0.5	-0.1	-0.2	-0.3	0.3	-0.1	-0.6	-0.0
Medication: Amlodipine	0.2	0.3	0.5	-0.7	-0.5	-0.7	-0.3	-0.3	-0.7	-0.7	0.7	0.3	-0.1	-0.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.5	-1.2	-0.6	0.3	0.5	-0.9	-0.7	0.3	-0.1	-0.3	-1.1	0.3
Birth weight	0.5	1.0	2.7	0.9	1.6	0.6	0.6	1.0	1.5	-0.1	1.6	0.4	-0.3	0.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.6	-0.3	-1.2	0.4	-0.5	0.2	-0.5	-0.9	-0.7	-1.3	0.0	-0.1
High blood pressure (siblings)	2.2	3.2	8.9	-1.4	-0.5	2.4	1.0	-1.8	-1.2	-1.2	-1.7	-1.7	-2.3	3.0
Forced vital capacity (FVC), Best measure	2.5	9.2	22.2	4.7	3.7	0.2	2.8	4.5	4.1	2.7	3.0	-0.9	1.4	-1.2
Body fat percentage	1.9	7.7	19.5	-4.4	-3.2	1.1	-0.5	-4.1	-3.6	-1.9	-3.0	-0.2	-2.4	2.3
Leg fat percentage (right)	2.2	7.9	16.6	-4.1	-3.5	1.5	-0.7	-3.6	-3.4	-2.8	-3.4	-0.9	-2.2	2.3
Arm fat-free mass (right)	0.1	0.4	1.7	-0.8	-1.3	1.0	0.3	-0.3	-0.4	-0.7	-0.2	-0.5	-0.0	0.7
Exposure to tobacco smoke outside home	0.3	0.3	1.0	0.2	-0.5	-0.7	0.5	0.2	0.2	-0.9	-1.0	0.6	0.0	-0.7
Comparative body size at age 10	0.7	1.9	5.9	-1.5	-1.5	0.6	-0.3	-0.7	-0.8	-2.2	-2.4	-1.8	-1.0	0.5
Number of full brothers	0.6	0.7	1.9	-0.6	-1.0	0.9	-0.0	-0.4	-0.7	-1.1	-0.9	-1.4	-0.7	0.7
Worry too long after embarrassment	0.5	0.9	2.3	-1.2	-1.3	-0.2	-1.5	-0.4	-0.9	0.8	-1.4	-0.2	0.9	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.5	-0.6	-1.0	0.3	-0.9	-0.4	-0.8	-0.1	-1.2	0.0	-0.5	0.7
Wheeze or whistling in the chest in last year	0.5	0.9	3.9	-0.2	-0.8	0.9	1.3	-0.3	0.7	0.4	0.2	0.5	-2.0	1.4
Number of children fathered	1.0	1.1	3.7	-0.4	-1.5	1.0	1.2	-0.8	-0.2	-0.3	-0.1	-1.3	-1.9	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.0	-1.6	-1.6	-0.9	-0.8	-1.8	-1.7	-0.4	-0.8	2.0	-0.3	0.1
Age at first live birth	0.2	0.4	1.1	-0.6	0.6	0.4	-0.7	-0.6	-0.6	-1.1	-0.8	-0.7	-0.2	0.0
Pulse wave peak to peak time	1.2	1.4	4.9	-0.8	-0.9	-0.7	-2.2	-0.2	-0.9	-0.3	-1.7	0.4	1.9	-1.0
Health satisfaction	1.1	1.4	3.6	0.4	0.1	1.6	1.7	0.8	0.8	-1.6	0.1	-0.5	-1.5	1.9
Shortness of breath walking on level ground	0.5	0.6	3.3	0.6	0.2	0.6	1.8	0.8	0.6	-0.2	-0.1	-0.0	-1.0	0.3
Qualifications: College or University degree	0.3	1.0	3.0	0.7	1.2	-1.3	-0.3	0.6	0.2	1.6	-0.4	0.1	1.0	-1.7
Eye problems/disorders: None of the above	0.4	0.4	1.5	-0.6	-0.6	-0.1	1.1	-0.2	-0.0	0.3	-0.4	0.9	-1.2	0.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.0	-0.3	-0.5	0.8	1.4	-0.5	0.0	-1.2	-0.5	-1.1	-1.1	0.8
Emphysema/chronic bronchitis	0.3	0.3	2.1	0.6	0.7	0.2	0.4	0.3	0.4	0.1	1.5	-0.1	0.0	0.3
Medication for pain relief, constipation, heartburn	1.1	1.9	4.0	1.2	1.2	-1.4	-1.6	1.6	0.9	0.9	0.4	1.3	1.7	-2.0
Neck or shoulder pain in last month	0.9	1.3	5.0	1.3	-0.4	1.2	2.2	0.7	1.1	0.3	-0.1	-0.8	-1.6	1.0
Medication: Blood pressure	1.7	3.1	7.5	-2.7	-2.7	-0.8	-1.2	-2.7	-2.6	0.7	-0.8	0.9	-0.8	-0.1
Angina (self-reported)	0.7	1.0	4.2	0.3	0.1	1.0	1.4	0.3	0.7	-0.7	0.5	-1.0	-2.1	1.0
Migraine (self-reported)	0.9	1.2	3.3	-0.8	-1.1	1.7	0.8	-0.6	-0.5	-0.5	-0.9	-1.1	-1.1	1.8
Medication: Ibuprofen	1.0	1.2	3.5	-0.4	-0.6	1.7	1.9	-0.4	0.2	-0.8	-0.1	-0.9	-1.2	1.6
Medication: Allopurinol	1.0	1.3	3.1	0.4	-1.0	-1.5	-0.3	0.6	0.9	1.8	0.9	1.6	1.1	-1.6
Medication: Omeprazole	1.3	1.5	3.9	-1.2	-1.1	-2.0	-0.6	-1.2	-1.2	1.3	-1.3	1.2	0.2	-1.4
Medication: Seretide 50 evohaler	0.8	0.9	2.8	-1.2	-0.4	0.5	0.3	-0.7	-0.7	-1.7	-0.5	-1.0	-1.6	0.7
Mean time to correctly identify matches	0.2	0.4	1.1	-0.7	-0.9	0.0	-1.1	-0.3	-0.8	-0.3	-0.7	0.6	0.3	0.1
Heart disease (mother)	0.3	0.4	1.2	0.1	0.7	0.2	1.1	-0.2	0.3	-0.1	0.9	-0.6	-1.0	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.2	3.8	9.2	-2.9	-2.6	0.2	0.1	-3.0	-2.5	-2.2	-1.8	-0.1	-1.4	1.2
Whole body fat mass	1.4	5.8	15.3	-3.9	-3.0	1.1	-0.1	-3.5	-2.9	-1.8	-2.3	-0.3	-2.3	1.9
Leg fat mass (right)	1.7	6.8	16.2	-4.0	-3.5	1.4	-0.6	-3.4	-3.2	-2.3	-2.7	-0.8	-2.0	2.1
Arm predicted mass (right)	0.1	0.4	1.2	-0.7	-1.1	1.1	0.6	-0.1	-0.3	-0.8	-0.1	-0.4	-0.1	0.8
Pulse rate, automated reading	2.4	7.8	27.6	-1.3	-1.7	4.7	-0.3	-1.2	-1.9	-2.8	-2.3	-3.0	-2.1	5.2
Alcohol intake frequency.	0.4	0.9	3.8	0.2	0.4	-0.5	-1.9	0.8	0.1	0.3	-0.2	0.6	1.9	-0.8
Comparative height size at age 10	0.9	5.1	17.9	2.2	2.7	1.1	4.2	1.6	2.8	1.8	1.7	-1.4	-2.4	0.5
Number of full sisters	0.7	0.8	1.9	-0.8	-0.9	-1.0	-1.4	-0.6	-0.8	0.0	-0.2	1.2	1.3	-1.0
Suffer from ‘nerves’	0.1	0.1	1.2	-0.1	-0.0	-0.0	-0.1	0.0	-0.1	0.1	-1.1	0.5	-0.0	0.3
Overall health rating	0.6	1.2	6.0	0.1	-0.4	0.7	2.2	-0.0	0.6	-0.5	-0.3	-1.0	-2.5	0.6
Chest pain or discomfort	0.3	0.5	2.3	-0.3	-0.9	-1.2	-0.2	-0.1	-0.2	-0.2	-0.4	0.5	0.0	-1.5
Had major operations	1.0	1.2	4.0	-1.0	-0.5	0.8	-2.0	-0.7	-1.4	-0.6	-1.3	-0.5	0.6	1.3
Age at last live birth	0.2	0.2	0.6	0.8	0.6	-0.2	-0.1	0.7	0.7	0.2	-0.1	0.1	0.3	-0.8
Family relationship satisfaction	0.5	0.6	1.4	0.7	0.8	0.2	0.7	1.2	1.0	-0.4	-0.5	-1.1	-0.8	-0.3
Leg pain on walking	1.1	1.4	3.4	-1.8	-1.8	-0.3	-1.2	-1.4	-1.7	-1.4	-0.6	0.2	0.0	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.4	0.4	-0.4	0.1	-0.1	0.6	0.6	0.6	-0.4	0.1	-0.0	0.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.3	-0.6	-1.1	0.2	0.5	-1.5	-0.7	1.2	-0.1	-0.7	-1.3	0.4
Illness, injury, bereavement, stress in last 2 years	2.1	2.5	6.1	2.4	2.5	1.2	1.0	1.9	2.2	0.9	1.0	-1.8	-0.1	0.2
Medication: Aspirin	0.9	1.2	5.5	-0.6	-0.5	1.3	1.4	-0.7	-0.2	-0.2	0.3	-1.0	-2.3	1.5
Supplements: Vitamin C	3.0	3.5	7.7	2.6	2.1	0.8	2.1	2.5	2.4	1.2	2.8	0.0	-1.1	0.2
Knee pain experienced in last month	1.0	1.6	4.3	-1.3	-1.0	1.4	1.0	-1.1	-0.9	-0.8	-0.7	-2.1	-1.7	1.3
Hypertension (Self-reported)	0.1	0.3	1.0	0.4	-0.4	-0.8	0.5	0.1	0.2	0.6	1.0	0.6	-0.6	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.8	-0.0	-0.3	0.2	0.9	-0.1	0.1	0.3	0.3	-0.7	-0.4	0.2
Illnesses of father: Heart disease	0.7	1.0	2.8	-1.0	-1.7	0.4	-1.2	-1.0	-1.0	-1.1	-1.3	-0.8	-0.1	0.5
Illnesses of siblings: Diabetes	0.8	0.9	4.9	-0.2	-0.5	-1.9	-0.1	0.1	-0.2	1.1	-0.2	-0.3	0.2	-2.2
Smoking status: Previous	0.4	0.5	2.0	0.6	-0.1	1.4	-0.0	0.9	0.3	-0.5	-0.1	-1.3	-0.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	1.2	0.9	-0.1	0.2	0.4	1.1	1.0	-0.1	0.2	0.0	0.6	0.2
Whole body fat-free mass	0.1	0.6	2.0	0.3	-0.1	1.1	1.4	0.8	0.9	0.0	0.8	-0.5	-0.3	0.5
Leg fat-free mass (right)	0.1	0.3	1.3	-0.5	-0.1	0.8	1.1	-0.3	0.1	-0.0	0.8	0.1	-0.2	0.6
Arm fat percentage (left)	1.6	6.2	16.5	-4.1	-2.7	1.3	-0.2	-3.6	-3.0	-1.7	-2.6	-0.4	-2.3	2.3
Average weekly red wine intake	1.2	1.7	6.1	1.6	2.5	0.3	-0.2	2.0	1.7	0.7	1.2	0.1	1.1	-0.5
Handedness (chirality/laterality): Left-handed	1.5	1.8	5.4	-0.3	0.2	1.9	1.7	-0.5	-0.2	-2.0	-0.7	-1.1	-1.4	2.3
Mood swings	1.2	2.2	7.4	-1.7	-1.9	-1.7	-1.0	-1.5	-1.4	-0.6	-0.8	2.7	0.4	-1.0
Loneliness, isolation	0.7	1.0	4.0	-0.2	-0.4	-1.6	-0.5	0.5	0.1	2.0	-0.9	0.3	0.6	-1.6
Long-standing illness, disability or infirmity	1.0	1.5	8.3	-0.3	-0.0	0.5	2.1	-0.6	0.6	1.1	0.6	-0.4	-2.9	0.8
Ever had bowel cancer screening	1.8	2.1	4.2	1.8	1.7	1.7	2.0	1.6	1.7	-0.3	1.2	-0.2	-0.5	1.6
Diabetes diagnosed by doctor	1.5	2.5	6.2	-2.5	-1.8	-1.5	-1.6	-2.1	-2.0	-0.3	-1.5	1.3	0.1	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	4.7	1.1	0.6	-1.7	0.5	0.8	1.3	0.2	2.1	2.2	0.7	-1.8
Friendships satisfaction	0.2	0.3	1.4	0.3	0.4	-0.8	0.4	0.7	0.3	-0.1	-0.0	-0.1	-0.2	-1.2
Qualifications: nursing, teaching	0.6	1.0	3.2	0.4	0.8	-1.0	-1.8	0.6	0.1	0.0	0.6	0.9	1.4	-1.4
Commuting to job workplace: Walk	0.9	0.9	3.5	-0.1	1.2	1.2	0.7	0.4	0.2	-1.9	0.8	-0.7	-0.7	1.2
Eye problems/disorders: Cataract	1.0	1.1	4.5	1.2	1.6	-0.2	-1.3	0.9	0.6	-0.2	0.8	-0.1	2.1	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	3.6	-1.5	-1.3	0.1	0.1	-1.9	-1.4	-0.3	-1.6	0.7	-0.5	0.8
Medication for cholesterol	0.6	0.9	3.0	-1.7	-0.3	-0.3	-0.7	-1.5	-1.4	-0.3	-1.4	0.1	-0.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	4.4	1.7	1.0	0.5	2.1	1.4	1.6	1.0	2.1	0.2	-0.3	0.2
Back pain experienced in last month	0.8	1.1	4.9	0.7	-0.1	0.9	2.2	-0.0	0.8	0.3	-0.0	-1.2	-1.9	0.7
Mineral and other dietary supplements	0.4	0.5	3.2	0.5	0.3	0.7	0.1	0.7	0.2	-1.8	0.2	0.3	1.0	0.6
Breast cancer (self-reported)	0.5	0.5	2.0	-0.5	-0.4	0.4	-1.4	-0.7	-1.1	-0.6	-0.4	-1.0	0.1	0.5
Asthma (self-reported)	0.7	1.5	4.7	0.1	-0.3	1.7	1.5	-0.1	0.9	-0.5	0.3	-1.4	-2.2	1.8
Osteoporosis (self-reported)	0.4	0.4	1.6	-0.5	0.5	-0.9	-0.2	-0.8	-0.1	0.6	0.3	1.2	-0.5	-0.8
Osteoarthritis (self-reported)	0.1	0.2	0.4	-0.5	0.2	-0.1	0.5	-0.6	-0.1	-0.5	0.2	0.5	-0.6	0.1
Medication: Aspirin	1.0	1.3	5.8	-0.7	-0.6	1.1	1.4	-0.7	-0.3	-0.1	0.4	-1.2	-2.4	1.4
Medication: Gliclazide	0.5	0.6	1.8	-1.3	-0.5	-0.3	-0.9	-0.8	-1.1	-0.9	-0.5	-0.4	-0.4	0.0
Illnesses of father: None of the above (group 1)	0.5	0.6	1.5	0.8	0.5	0.7	1.2	1.2	1.0	-0.5	0.7	0.2	-0.4	0.7
Smoking status: Current	0.6	0.9	2.7	0.3	-0.0	1.2	1.2	0.2	0.3	-1.6	0.7	-1.2	-1.0	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	6.5	2.0	2.5	0.3	0.3	2.1	1.3	1.4	1.7	0.1	2.0	-0.6
Whole body water mass	0.1	0.5	1.9	0.2	-0.1	1.0	1.4	0.7	0.8	0.0	0.8	-0.4	-0.2	0.5
Leg predicted mass (right)	0.1	0.3	1.1	-0.6	-0.2	0.7	1.0	-0.4	0.0	-0.1	0.7	0.2	-0.1	0.6
Arm fat mass (left)	1.0	4.3	11.1	-3.3	-2.4	1.2	0.1	-2.8	-2.4	-1.8	-2.1	-0.4	-1.8	1.9
Number of self-reported non-cancer illnesses	0.8	1.4	5.1	-0.3	-0.7	1.1	1.7	-0.8	0.2	-0.2	1.1	0.0	-2.2	1.7
Average weekly champagne plus white wine intake	0.3	0.4	0.9	0.9	0.6	-0.6	0.1	0.7	0.9	0.9	-0.0	0.7	0.5	-0.6
Miserableness	0.2	0.4	1.1	-0.5	-0.8	-0.2	0.2	-0.4	-0.4	-0.8	-1.1	0.8	0.7	0.2
Guilty feelings	0.5	0.8	2.5	-0.4	-0.6	1.5	0.3	0.1	0.1	-0.7	-0.8	-0.9	-1.1	1.6
Wears glasses or contact lenses	0.3	0.4	1.2	-1.0	-0.7	0.3	-0.3	-1.1	-0.8	0.3	0.1	-0.2	-0.6	0.5
Ever taken oral contraceptive pill	1.2	1.4	4.0	0.9	0.4	2.0	1.6	1.1	0.5	-0.1	-0.4	-1.5	-0.5	1.9
Hearing aid user	0.6	0.7	3.4	0.4	0.7	0.2	1.8	0.1	0.7	1.2	0.6	-0.2	-0.9	0.2
Mother’s age at death	0.0	0.1	0.2	0.1	-0.1	-0.4	0.5	0.1	-0.1	0.2	0.3	0.0	-0.3	-0.1
Financial situation satisfaction	0.8	1.0	2.7	-1.1	-0.7	0.6	0.7	-0.5	-0.7	-1.6	-1.1	-0.5	-1.6	0.9
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.2	1.0	0.2	1.2	1.8	0.9	0.7	-0.9	0.4	0.0	-0.2	1.5
Commuting to job workplace: Public transport	0.7	0.8	3.3	1.0	1.0	0.3	-0.2	1.7	0.9	-0.3	-0.1	0.5	1.8	0.3
Eye problems/disorders: Glaucoma	0.3	0.3	1.4	-0.3	-1.2	0.0	0.1	-0.2	-0.1	-0.6	-0.8	-0.6	-0.8	0.3
Medication: Blood pressure	0.2	0.3	0.9	0.9	-0.1	-0.2	0.4	1.0	0.6	-0.3	0.9	-0.1	-0.1	-0.3
Pain type(s) experienced in last month: Hip pain	1.1	1.4	4.8	-0.2	-0.7	1.2	2.2	-0.4	0.1	-0.4	0.2	-2.0	-1.8	0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.2	-0.6	-0.3	-1.0	0.4	-1.1	-0.4	1.3	0.1	0.1	-1.5	-0.5
High cholesterol (Self-reported)	0.2	0.4	1.2	0.7	0.1	1.1	0.2	0.6	0.9	0.6	0.3	0.2	0.6	0.8
Medication: Bendroflumethiazide	0.4	0.6	1.5	-0.1	-0.8	-1.1	-0.8	0.1	-0.5	0.8	-0.2	0.6	1.2	-1.2
Medication: Paracetamol	0.8	1.3	3.3	-1.6	-1.6	-0.2	-0.6	-1.8	-1.6	-0.3	-1.6	-0.4	-0.2	0.3
Medication: Lisinopril	2.0	2.6	6.8	-1.8	-2.6	-1.3	-2.0	-1.6	-2.3	-0.3	-1.7	-0.5	0.0	-1.3
Medication: Atorvastatin	0.3	0.4	1.2	0.1	-0.0	0.7	0.9	-0.3	0.5	-0.5	0.2	0.9	-0.6	1.1
Illnesses of father: High blood pressure	0.7	0.9	2.5	-0.8	-0.8	-1.6	-0.7	-0.9	-0.7	1.1	-1.1	0.4	0.2	-1.2
Alcohol drinker status: Never	2.2	2.6	7.7	2.6	2.1	0.2	0.8	2.8	2.4	1.2	1.2	0.5	1.1	-0.2
Ever smoked	0.5	0.9	2.2	0.4	0.5	1.5	1.4	0.2	0.4	-0.9	0.9	-0.7	-1.1	1.4
Basal metabolic rate	0.1	0.5	2.1	-0.2	-0.4	1.2	1.4	0.3	0.5	-0.3	0.5	-0.5	-0.6	0.8
Leg fat percentage (left)	2.6	9.4	20.4	-4.5	-4.0	1.6	-1.1	-4.1	-3.9	-2.8	-3.5	-0.9	-2.1	2.5
Arm fat-free mass (left)	0.1	0.3	1.1	-0.2	-0.6	1.0	0.7	0.4	0.2	-0.5	0.3	-0.5	0.0	0.5
Number of operations (self-reported)	2.0	3.0	6.0	-2.2	-2.2	0.7	-1.8	-2.1	-2.5	-1.9	-1.6	0.2	-0.6	1.6
Average weekly beer plus cider intake	0.1	0.1	0.4	-0.6	-0.4	-0.2	-0.4	-0.5	-0.4	0.2	-0.1	0.6	0.0	-0.2
Irritability	0.6	1.0	4.1	-0.7	-1.3	-0.8	0.1	-0.5	-0.5	0.2	-1.9	2.0	0.3	-0.3
Risk taking	1.1	1.6	4.4	1.9	0.5	1.4	1.3	2.1	1.8	-0.5	1.1	-0.2	-0.3	1.0
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.8	0.4	1.3	-0.8	0.3	-0.1	0.2	1.6	1.6	1.7	0.3	-0.3
Fractured/broken bones in last 5 years	1.6	2.1	5.2	-0.2	-0.7	-2.1	-2.3	0.3	-0.2	0.7	-0.0	2.1	1.7	-2.2
Age started oral contraceptive pill	0.5	0.6	2.5	-0.6	0.7	0.0	-1.5	-0.0	-0.8	-0.0	-1.6	0.3	0.2	0.0
Diastolic blood pressure, automated reading	0.4	1.1	3.6	0.8	0.7	1.1	1.9	-0.1	1.0	0.9	1.1	0.7	-1.0	1.3
Ever depressed for a whole week	1.4	1.8	4.4	0.7	0.4	-1.8	-1.2	0.8	0.3	2.0	-0.3	1.5	1.6	-2.1
Unable to work because of sickness or disability	1.1	1.4	4.5	-1.1	-1.0	0.6	0.9	-1.4	-1.0	-0.8	-1.3	-1.0	-2.1	0.9
Commuting to job workplace: Cycle	0.8	1.0	2.6	-1.6	-1.4	-0.4	0.2	-1.6	-1.4	0.5	-1.1	0.3	-0.5	0.1
Myopia	4.1	5.9	13.8	-3.2	-3.7	0.8	-1.0	-2.8	-3.5	-2.6	-2.8	-1.9	-0.7	1.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.0	-0.4	0.2	0.1	-0.8	0.0	-0.3	-0.1	-1.0	-0.4	0.9	-0.0
Cholesterol lowering medication	0.5	0.8	2.0	0.9	-0.2	1.2	1.0	1.2	1.2	-0.3	0.5	-1.4	-0.4	0.3
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.8	-1.1	-1.2	-1.9	-0.8	-1.2	-1.4	1.0	-1.4	1.2	0.3	-1.4
Pain experienced in last month	1.4	2.3	7.1	-0.2	0.5	-2.1	-2.7	0.2	-0.3	0.9	0.7	1.6	2.4	-2.0
Supplements: Calcium	0.5	0.5	1.4	-0.8	-0.3	-0.7	-0.2	-0.7	-0.6	0.5	0.8	1.2	-0.9	-0.6
Basal cell carcinoma (self-reported)	0.6	0.7	2.8	-0.8	-1.2	1.0	0.3	-0.4	-0.5	-1.1	0.4	0.0	-0.6	1.7
Heart attack/myocardial infarction (self-reported)	1.1	1.4	4.0	-1.6	-2.0	-0.1	-0.7	-1.4	-1.8	-1.2	-1.1	0.0	-0.8	0.3
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.6	0.3	0.6	1.0	1.6	-0.0	0.9	0.4	1.2	-0.1	-1.1	1.5
Heart disease (siblings)	0.7	0.8	3.2	0.7	0.2	-0.7	-1.8	0.9	0.5	0.5	-0.3	-0.8	1.1	-1.2
Alcohol drinker status: Previous	0.4	0.5	1.3	0.8	0.3	0.7	0.4	0.9	1.1	0.3	0.4	0.3	-0.7	0.8
Pack years of smoking	0.8	1.2	3.3	-1.4	-1.8	-1.1	-1.3	-0.7	-1.1	-1.0	-0.9	0.1	-0.1	-1.2
Impedance of whole body	0.2	0.8	3.5	1.2	1.9	-1.2	0.1	0.6	0.7	0.9	0.2	0.6	0.2	-0.8
Leg fat mass (left)	1.9	7.4	17.3	-4.2	-3.7	1.5	-0.6	-3.6	-3.4	-2.5	-2.7	-0.8	-1.9	2.2
Arm predicted mass (left)	0.1	0.4	1.1	-0.6	-0.9	1.0	0.7	-0.0	-0.0	-0.7	0.1	-0.5	-0.3	0.7