Hub : Genes

RP11-731C17.2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.156 0.0660 1.6e-03 0.021 NA 0.087 NA 0.071 9.2e-02 NA 3.0e-03 NA 6.8e-03
2 GTEx Brain Cerebellum 0.310 0.0900 1.0e-05 0.054 NA 0.119 NA 0.104 1.1e-02 NA 2.3e-04 NA 5.5e-04
3 GTEx Brain Cortex 0.109 0.0580 9.3e-03 0.079 NA 0.043 NA 0.092 3.3e-03 NA 2.4e-02 NA 1.6e-03
4 GTEx Brain Hippocampus 0.187 0.0762 6.8e-04 0.063 NA 0.107 NA 0.087 1.4e-02 NA 1.8e-03 NA 4.6e-03
5 GTEx Cells EBV-transformed lymphocytes 0.189 0.0760 9.3e-04 0.025 NA 0.018 NA 0.015 5.1e-02 NA 8.4e-02 NA 1.0e-01
6 GTEx Esophagus Muscularis 0.160 0.0610 2.1e-05 0.028 NA 0.063 NA 0.048 8.1e-03 NA 1.1e-04 NA 7.0e-04
7 GTEx Muscle Skeletal 0.152 0.0450 4.8e-12 0.122 NA 0.116 NA 0.124 5.5e-12 NA 1.9e-11 NA 3.8e-12
8 GTEx Pancreas 0.086 0.0420 5.3e-03 0.033 NA -0.002 NA 0.017 1.6e-02 NA 3.8e-01 NA 6.0e-02
9 GTEx Testis 0.105 0.0560 1.0e-02 0.030 NA 0.002 NA 0.000 1.7e-02 NA 2.5e-01 NA 3.1e-01
10 GTEx Thyroid 0.061 0.0300 1.1e-03 0.029 NA 0.018 NA 0.017 2.5e-03 NA 1.5e-02 NA 1.7e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.6 1.0 2.8 -0.6 -1.1 -1.3 -0.2 0.0 -1.7 -1.6 0.5 1.0 0.1
Bipolar Disorder or Schizophrenia 2.6 6.5 10.9 -3.3 -1.5 -2.8 -3.1 0.0 -1.0 -2.2 3.1 3.1 3.0
Depressed Affect (Nagel 2018) 1.4 2.9 9.4 -0.2 2.6 0.7 -0.9 0.0 3.1 1.9 1.0 -0.0 2.6
Depression (Nagel 2018) 2.3 3.5 13.4 -1.1 2.4 -0.3 -1.4 0.0 3.7 1.3 1.9 0.1 2.8
Intelligence (Savage-Jansen 2018) 2.0 6.0 31.1 -0.1 -3.1 -0.1 1.1 0.0 -5.6 -2.1 -1.7 1.8 -2.8
Neuroticism (Nagel 2018) 2.5 5.9 15.2 -2.4 1.4 -1.3 -3.2 0.0 3.5 0.6 3.0 1.7 3.9
Schizophrenia (2018) 3.7 7.7 14.9 -3.8 -1.1 -2.6 -3.9 0.0 0.0 -1.5 3.6 3.2 3.8
Schizophrenia vs Biploar Disorder 0.9 1.1 2.6 -1.6 0.8 -0.6 -1.4 0.0 1.5 0.6 1.3 -0.2 1.2
Worry (Nagel 2018) 3.7 7.7 18.6 -3.3 0.0 -2.3 -4.3 0.0 2.6 -0.5 3.6 2.9 3.7
Alzheimer’s Disease (in mother) 0.2 0.2 0.9 -0.9 0.3 -0.1 -0.8 0.0 0.6 0.2 0.0 -0.2 -0.6
Alzheimer’s Disease (in father) 2.5 2.7 6.0 1.6 2.5 1.9 1.4 0.0 0.3 1.9 -1.9 -1.0 -2.2
Alzheimer’s Disease (including proxy) 1.6 2.3 6.1 0.2 2.5 1.6 0.4 0.0 1.2 2.2 -1.4 -1.1 -2.1
Crohns Disease (2017) 1.3 2.8 7.0 -1.9 -2.3 -1.9 -1.1 0.0 -0.8 -2.6 1.3 1.9 1.2
Irritable Bowel Disease (IBD) 1.8 4.3 8.1 -2.0 -2.4 -2.6 -1.5 0.0 -1.2 -2.9 2.0 2.7 1.9
Ulcerative Colitis (UC) 1.1 2.0 4.6 -0.9 -1.4 -1.7 -0.9 0.0 -1.4 -1.7 1.4 2.1 1.4
Major Depression (MDD) 0.3 0.4 2.9 0.4 0.3 0.3 0.3 0.0 0.5 0.4 0.4 -0.6 1.7
Reaction Time 0.8 1.6 4.1 -2.0 1.0 -0.8 -1.9 0.0 1.3 0.1 1.4 0.4 1.5
Verbal and Numeric Reasoning (VNR) 1.4 3.3 15.7 -0.5 -2.4 -0.4 0.5 0.0 -4.0 -1.8 -1.1 1.7 -1.9
Breast Cancer 1.3 3.2 5.2 2.2 1.1 2.1 2.2 0.0 -1.8 1.6 -2.3 -1.5 -2.0
Ovarian Cancer 0.7 0.9 2.4 0.9 -0.2 1.0 0.9 0.0 -0.9 0.4 -1.1 -1.5 -1.3
Prostate Cancer 1.2 1.8 3.8 1.7 1.3 1.9 1.2 0.0 -0.4 1.4 -1.8 -0.4 -1.5
Age at First Birth 0.8 1.2 2.7 -1.6 -1.2 -0.7 -1.7 0.0 -1.3 -1.3 0.5 1.1 0.2
Bipolar Disorder (2011) 1.8 1.7 5.1 -0.7 -2.3 -1.4 -0.8 0.0 -1.9 -1.5 1.0 0.9 1.2
Body Mass Index (BMI) (2010) 3.7 5.1 10.0 2.1 3.1 2.0 1.9 0.0 3.1 3.2 -0.9 -2.9 -0.6
Coronary Artery Disease (CAD) 0.9 1.1 3.2 1.8 1.5 1.1 1.2 0.0 0.0 1.4 -0.4 -0.8 0.1
Crohns Disease (2012) 0.6 1.0 2.2 -1.2 -1.4 -1.1 -0.3 0.0 1.1 -1.5 0.6 0.8 0.7
Mean Putamen Volume 0.3 0.4 1.1 -1.1 -0.5 0.2 -0.8 0.0 0.0 0.1 -0.3 -0.8 -0.9
Fasting Glucose 1.4 1.7 7.4 0.0 1.0 1.2 -0.1 0.0 2.7 1.6 -0.8 -1.6 -1.2
HbA1C 0.2 0.2 0.7 0.4 0.2 -0.8 0.8 0.0 -0.0 -0.5 0.2 -0.1 -0.1
HDL Cholesterol 4.0 6.7 14.1 -3.8 -3.6 -1.8 -3.5 0.0 -2.8 -2.8 1.1 2.7 0.7
LDL Cholesterol 0.8 1.2 3.8 1.0 1.6 0.5 0.8 0.0 2.0 1.3 0.3 -0.3 1.2
Lupus 0.8 1.3 2.7 -1.6 -1.3 -1.2 -1.3 0.0 0.6 -1.1 1.2 1.1 1.1
Neuroticism (2016) 2.4 3.5 9.2 -1.6 -0.3 -1.3 -2.1 0.0 2.3 -0.8 2.4 2.4 3.0
Primary Biliary Cirrhosis 0.1 0.2 0.8 0.1 0.4 0.3 0.5 0.0 -0.6 0.3 -0.4 0.0 -0.9
Rheumatoid Arthritis 0.5 0.7 1.7 -1.0 -0.6 -0.6 -1.3 0.0 1.2 -0.9 0.4 0.9 0.8
Schizophrenia (2014) 4.0 8.9 18.1 -4.3 -1.4 -2.9 -4.2 0.0 -0.1 -1.9 3.7 3.4 3.8
Triglycerides 2.9 4.8 14.1 3.8 2.8 1.5 2.7 0.0 2.4 2.6 -0.1 -1.7 0.8
Type 2 Diabetes (T2D) (2012) 1.0 1.1 3.4 1.8 1.4 0.5 1.7 0.0 1.2 0.8 -0.1 -0.8 -0.1
Ulcerative Colitis 0.6 0.9 1.9 -1.0 -0.8 -1.4 -0.8 0.0 -0.4 -1.0 1.1 1.2 0.9
Blood Eosinophil Count 0.9 7.1 16.2 4.0 2.6 3.2 2.9 0.0 1.9 4.0 -1.9 -2.1 -1.5
Blood Platelet Count 3.5 40.3 80.8 8.1 5.5 7.3 9.0 0.0 -1.2 5.7 -8.1 -4.9 -7.1
Blood Red Count 0.6 5.9 15.1 2.0 2.2 2.8 1.3 0.0 2.8 3.2 -1.8 -3.9 -2.1
Blood White Count 4.5 33.0 52.4 7.0 5.1 6.5 7.2 0.0 1.4 6.4 -6.4 -6.0 -6.3
Heel T-Score 0.9 7.1 11.6 3.3 2.3 3.4 3.1 0.0 -0.0 3.3 -3.2 -2.0 -2.9
BMI 5.6 32.3 66.3 8.1 5.8 5.9 7.1 0.0 5.3 7.5 -3.5 -6.1 -1.9
Height 3.9 75.2 193.2 -8.9 -12.6 -9.6 -6.0 0.0 -10.1 -13.9 3.9 8.6 2.2
Waist Hip Ratio (WHR) 2.4 10.7 25.7 4.1 1.1 2.9 5.1 0.0 -2.5 1.2 -4.4 -2.8 -4.5
Systolic Blood Pressure 0.5 2.3 7.2 0.5 -1.8 -1.9 1.0 0.0 -2.5 -2.7 0.3 0.9 0.6
Smoking Status 0.5 1.1 3.3 0.3 1.7 0.9 0.8 0.0 -0.2 0.9 -1.2 -1.1 -1.8
Allergy or Eczema 0.3 0.7 2.8 -1.7 -0.0 -0.1 -1.4 0.0 -0.7 -0.3 0.4 1.0 0.5
Cardiovascular Disease 4.3 14.3 49.7 7.1 3.7 3.0 6.0 0.0 1.7 3.3 -2.5 -3.6 -1.2
Hypothyroidism (self reported) 0.2 0.4 0.9 -0.7 -0.9 -0.8 -0.3 0.0 -1.0 -0.7 0.3 0.4 0.3
Respiratory disease 1.4 3.0 5.9 2.2 2.2 2.3 1.7 0.0 0.2 2.4 -1.6 -1.0 -1.6
Type 2 Diabetes (T2D) (2018) 4.4 8.2 15.0 3.9 3.4 2.8 3.8 0.0 1.8 3.5 -2.2 -2.6 -2.5
Lung FEV1/FVC ratio 0.5 2.5 7.6 -2.1 -2.4 -1.9 -1.1 0.0 -1.0 -2.8 0.6 0.9 0.0
Lung FVC 0.2 1.2 5.1 1.6 2.3 0.7 0.8 0.0 0.6 1.7 0.0 -0.5 0.5
Neuroticism 2.7 6.4 15.2 -2.6 1.4 -1.1 -3.5 0.0 3.7 0.6 3.0 1.9 3.9
Chronotype (morning person) 0.1 0.3 0.9 0.9 0.2 -0.2 0.8 0.0 0.6 -0.3 0.3 0.3 0.8
Hair Pigment 0.0 1.2 5.7 0.4 1.1 1.5 -0.8 0.0 1.4 2.4 0.1 -0.2 -0.6
Tanning 0.2 2.2 5.6 -1.1 -1.8 -1.2 -1.1 0.0 -2.0 -2.4 0.1 2.3 0.7
Hand grip strength (left) 0.9 2.5 6.0 -1.2 -2.0 -2.0 -1.6 0.0 -1.1 -2.4 1.4 1.1 1.5
Number of treatments/medications taken 3.2 5.8 12.6 3.4 2.6 2.3 3.5 0.0 1.6 3.0 -1.7 -2.2 -1.7
Average weekly spirits intake 1.1 1.4 3.2 1.1 1.8 0.6 0.8 0.0 1.8 1.6 0.2 -1.4 0.9
Sensitivity / hurt feelings 1.3 2.2 6.1 -1.7 1.2 -0.1 -2.1 0.0 2.5 0.6 1.5 0.4 2.0
Frequency of depressed mood in last 2 weeks 2.3 3.3 9.7 -1.4 2.5 -0.8 -1.2 0.0 3.1 0.7 1.9 0.5 2.8
Hearing difficulty/problems: Yes 0.8 1.2 3.4 1.9 0.1 1.1 1.8 0.0 -1.2 0.7 -0.8 -0.7 -0.9
Relative age of first facial hair 5.7 11.7 18.6 -4.2 -3.1 -4.3 -3.8 0.0 -0.5 -4.0 3.9 3.9 3.4
Other serious medical condition/disability diagnosed by doctor 5.4 7.0 10.7 2.6 3.3 3.1 3.2 0.0 1.0 2.9 -2.9 -2.6 -2.9
Ever used hormone-replacement therapy (HRT) 1.7 2.2 7.2 2.1 2.4 1.7 0.9 0.0 0.7 2.7 -0.2 -0.6 0.3
Ever had hysterectomy (womb removed) 0.2 0.3 2.5 -0.2 -0.1 0.1 0.1 0.0 -1.6 -0.2 -0.3 0.1 -0.2
Systolic blood pressure, automated reading 0.2 0.6 2.2 1.4 -0.4 -0.5 1.5 0.0 -0.1 -0.5 0.1 -0.5 0.9
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.6 -0.1 -0.8 -0.3 -0.2 0.0 -0.6 -0.8 -0.1 -0.0 0.2
Angina 2.3 3.0 6.7 2.5 2.6 1.5 1.4 0.0 2.4 2.4 -0.4 -0.8 0.1
Medication for hormone replacement therapy 1.4 1.6 4.6 1.1 1.9 1.4 0.6 0.0 1.4 2.1 -0.7 -0.5 -1.0
Vitamin and mineral supplements 1.3 1.7 4.3 1.3 0.6 1.7 1.4 0.0 -0.1 1.6 -1.6 -2.1 -0.9
Supplements: Zinc 0.2 0.2 0.6 0.2 -0.1 -0.4 0.3 0.0 -0.7 -0.5 0.4 0.8 0.5
Medication: Co-codamol 1.1 1.3 3.4 1.9 1.7 0.4 1.4 0.0 1.5 1.0 -0.0 -0.6 0.9
Medication: Metformin 2.6 3.7 9.2 1.8 2.3 1.8 1.6 0.0 2.8 3.0 -0.8 -2.0 -0.9
Diabetes (father) 0.8 1.0 2.1 1.5 1.0 -0.1 0.5 0.0 1.2 1.1 1.1 -0.6 1.4
Diabetes (mother) 0.7 0.9 2.2 1.1 1.1 0.7 1.5 0.0 1.0 0.9 -0.8 -1.1 -0.8
Severe depression (siblings) 0.2 0.2 0.6 -0.3 -0.8 -0.5 -0.4 0.0 -0.5 -0.5 0.2 0.0 0.2
Pack years adult smoking proportion 1.2 1.8 7.0 2.6 1.8 1.1 1.4 0.0 1.0 1.8 -0.5 0.0 0.3
Impedance of leg (right) 2.1 10.0 20.2 -4.3 -4.5 -2.2 -2.9 0.0 -4.5 -4.1 0.2 3.1 -1.0
Leg fat-free mass (left) 0.3 1.8 7.7 2.8 0.6 0.1 2.3 0.0 1.3 0.4 -0.1 -1.5 0.7
Trunk fat percentage 0.6 2.5 5.3 2.3 0.6 1.6 2.2 0.0 2.1 1.8 -1.2 -1.6 -0.7
Hand grip strength (right) 1.1 2.9 7.3 -1.0 -2.7 -2.1 -1.2 0.0 -1.1 -2.5 1.5 1.4 1.7
Townsend deprivation index at recruitment 1.4 2.0 5.2 -2.3 -1.6 -1.2 -2.0 0.0 -0.6 -1.5 0.8 1.8 0.3
Current tobacco smoking 0.7 1.1 3.3 0.3 1.8 1.0 0.8 0.0 1.6 1.4 -0.6 -0.8 -0.6
Average weekly fortified wine intake 0.5 0.6 3.5 -0.3 -1.1 0.3 -0.3 0.0 -1.9 -0.3 -0.4 0.7 -0.5
Maternal smoking around birth 1.0 1.4 2.9 1.5 1.4 1.7 1.2 0.0 1.5 1.3 -1.0 0.0 -0.6
Fed-up feelings 2.8 5.2 18.8 -1.2 1.0 -1.2 -2.6 0.0 3.3 0.6 3.0 1.4 4.3
Frequency of unenthusiasm / disinterest in last 2 weeks 3.1 4.1 12.9 -0.6 3.0 -0.8 -1.2 0.0 3.6 1.1 2.3 1.1 3.1
Relative age voice broke 7.2 11.0 19.6 -4.4 -2.9 -4.0 -3.9 0.0 0.6 -3.1 4.0 3.3 3.5
Taking other prescription medications 0.8 1.2 2.5 1.5 1.6 0.9 1.6 0.0 1.1 1.5 -0.4 -0.4 -0.4
Age when periods started (menarche) 1.0 2.3 11.1 -1.1 -0.9 -1.5 -0.6 0.0 3.3 -0.6 1.8 -0.6 1.8
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.6 1.3 0.4 1.0 1.2 0.0 -0.6 0.7 -1.2 -0.1 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 2.7 0.8 1.0 1.1 1.0 0.0 -1.3 0.5 -1.6 -0.2 -1.6
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.8 0.1 0.5 0.4 -0.2 0.0 0.8 0.9 0.1 0.4 0.0
Qualifications: CSEs or equivalent 0.6 0.8 2.0 1.2 1.4 0.6 0.9 0.0 0.8 1.1 -0.1 -1.1 0.4
Serious illness, injury or assault to yourself 0.4 0.5 1.5 1.2 0.0 0.3 1.1 0.0 -0.3 0.3 -0.6 -0.6 -1.0
High blood pressure 1.6 4.6 16.2 4.0 1.4 1.8 3.3 0.0 0.7 1.9 -1.6 -2.2 -1.3
Hayfever, allergic rhinitis or eczema 0.2 0.5 2.9 -1.7 0.2 0.1 -0.6 0.0 -1.1 -0.2 -0.2 0.9 -0.2
Multivitamins +/- minerals 0.5 0.6 2.9 -1.2 0.2 -0.7 -0.8 0.0 0.0 -0.8 0.4 1.7 -0.2
Stomach or abdominal pain in last month 1.3 1.7 6.5 -0.5 1.7 -0.0 -1.0 0.0 2.5 0.7 1.0 0.7 2.0
Supplements: Glucosamine 0.2 0.2 1.3 -0.3 1.1 0.1 -0.0 0.0 0.3 0.0 0.3 0.8 0.1
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.7 -0.3 -0.0 0.3 0.6 0.0 -0.1 -0.3 -0.8 0.6 -0.9
Medication: Atenolol 0.9 1.1 2.9 1.7 0.2 1.2 1.3 0.0 0.1 1.3 -1.2 -1.1 -0.5
Medication: Levothyroxine sodium 0.1 0.1 0.4 -0.6 -0.1 -0.3 -0.1 0.0 -0.6 -0.1 -0.3 0.1 -0.6
Sitting height 0.7 4.9 15.2 -0.5 -3.0 -3.0 -0.6 0.0 -2.2 -3.9 1.6 2.2 1.7
Chronic bronchitis/emphysema (father) 2.2 2.5 5.7 2.1 0.5 1.8 2.2 0.0 0.6 1.8 -1.3 -2.4 -1.2
High blood pressure (mother) 0.8 1.1 5.5 2.4 -0.1 0.4 1.6 0.0 0.3 0.5 -0.0 -0.8 1.4
Body mass index (BMI) 4.8 20.3 43.3 6.6 5.2 4.2 5.0 0.0 5.4 6.1 -1.8 -4.7 -0.1
Impedance of leg (left) 2.3 11.3 23.7 -4.9 -4.8 -2.7 -3.2 0.0 -4.1 -4.5 0.6 3.4 -0.5
Leg predicted mass (left) 0.3 1.8 7.7 2.8 0.7 0.1 2.3 0.0 1.4 0.4 -0.0 -1.4 0.8
Trunk fat mass 0.6 2.7 8.2 2.9 0.6 1.3 2.6 0.0 2.0 1.5 -1.0 -1.6 -0.3
Waist circumference 4.4 16.1 40.9 6.4 3.5 3.9 5.8 0.0 2.5 4.3 -3.0 -4.6 -1.8
Number of incorrect matches in round 2.2 3.6 11.2 -2.8 -3.3 -1.4 -2.6 0.0 -1.1 -1.5 1.5 1.1 1.2
Past tobacco smoking 1.0 1.8 3.7 -1.2 -1.2 -1.0 -1.7 0.0 0.9 -0.8 1.5 1.9 1.9
Alcohol usually taken with meals 1.5 2.4 5.8 -2.0 -2.4 -0.6 -0.8 0.0 -2.4 -1.7 -0.7 0.8 -1.9
Nervous feelings 5.4 10.1 23.2 -3.9 -1.2 -2.8 -4.8 0.0 1.6 -1.8 3.8 3.7 4.4
Frequency of tenseness / restlessness in last 2 weeks 3.2 5.0 12.8 -1.5 2.0 -1.6 -2.0 0.0 3.5 0.2 3.0 1.9 3.6
Hearing difficulty/problems with background noise 0.5 0.7 2.0 1.0 1.4 0.7 -0.1 0.0 1.0 1.1 0.7 -0.2 1.1
Hair/balding pattern: Pattern 2 0.2 0.3 1.0 0.8 -0.4 -0.3 0.5 0.0 -0.0 -0.6 -0.1 1.0 0.1
Had menopause 0.3 0.4 1.2 -0.5 -0.4 0.6 -0.9 0.0 -0.2 1.1 0.1 -1.0 0.5
Had other major operations 3.6 4.4 10.6 2.0 2.2 2.1 2.6 0.0 0.2 1.6 -2.6 -2.0 -3.3
Forced vital capacity (FVC) 0.7 2.7 7.0 -0.8 -2.0 -1.9 -0.9 0.0 -2.3 -2.7 0.8 1.8 1.1
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.4 6.3 1.2 1.5 2.0 1.4 0.0 -1.1 1.1 -2.5 -1.0 -2.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.6 -0.3 1.3 1.0 0.3 0.0 0.1 0.9 -1.0 0.2 -1.0
Qualifications: None of the above 0.4 0.9 2.6 1.4 0.9 0.5 0.2 0.0 1.6 0.9 0.4 0.1 1.5
Financial difficulties in last 2 years 0.2 0.3 1.2 0.1 0.8 -0.2 0.5 0.0 0.1 -0.7 -0.2 1.1 0.2
Mouth/teeth dental problems 2.3 3.5 9.8 -2.0 -2.9 -1.5 -0.5 0.0 -3.1 -2.9 -0.2 1.3 -0.4
Heart attack 6.2 7.9 23.5 4.8 3.1 2.8 4.0 0.0 1.6 3.0 -2.1 -2.2 -1.2
Allergy 0.3 0.8 3.4 -0.7 -1.9 -0.8 -1.1 0.0 0.3 -1.1 0.4 -0.5 0.3
Pain all over the body in last month 1.9 2.0 3.1 1.5 1.7 1.5 1.7 0.0 1.6 1.7 -1.0 -1.8 -0.4
Diabetes (self-reported) 2.5 3.9 8.4 2.2 2.4 2.1 1.6 0.0 2.7 2.9 -1.2 -1.6 -1.3
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 4.5 -1.3 -1.1 -1.6 -1.2 0.0 -1.3 -2.1 1.0 2.1 1.3
Medication: Ramipril 0.8 1.0 2.4 1.6 1.2 0.9 1.5 0.0 0.4 1.1 -0.9 -0.8 -0.5
Medication: Simvastatin 2.9 4.3 13.1 3.6 1.2 2.2 2.9 0.0 0.3 2.3 -1.8 -2.3 -0.9
Fluid intelligence score 1.7 3.5 14.2 -0.2 -2.2 -0.1 0.8 0.0 -3.8 -1.5 -1.4 1.9 -2.6
Illnesses of siblings 0.9 1.3 4.5 -1.5 -1.1 -0.2 -1.6 0.0 -2.1 -0.5 -0.3 1.2 -0.9
Neuroticism score 2.7 5.6 15.4 -2.4 1.0 -1.1 -3.1 0.0 3.1 0.1 2.8 2.3 3.9
Weight 0.7 3.5 13.2 3.6 0.9 1.2 3.0 0.0 1.8 1.6 -0.7 -2.1 0.3
Impedance of arm (right) 5.7 26.5 57.8 -7.6 -7.1 -4.2 -5.5 0.0 -5.9 -6.8 1.1 5.0 -1.1
Arm fat percentage (right) 1.7 6.8 14.3 3.8 2.2 2.6 2.9 0.0 3.4 3.5 -1.4 -2.8 -0.5
Trunk fat-free mass 0.2 1.0 4.7 2.2 -0.2 -0.9 1.7 0.0 -0.1 -0.7 0.5 -0.3 1.0
Hip circumference 1.7 7.3 23.6 4.9 2.1 2.3 3.7 0.0 2.2 3.1 -1.1 -3.2 0.2
Time employed in main current job 0.5 0.6 3.2 0.1 0.0 -0.3 -0.5 0.0 1.8 0.7 0.9 -0.0 1.1
Alcohol intake versus 10 years previously 0.1 0.2 0.9 -0.1 -0.2 -0.1 -0.1 0.0 -0.5 -0.3 -0.3 1.0 -0.4
Father’s age at death 0.2 0.3 1.1 -1.1 0.2 0.3 0.0 0.0 0.3 0.8 -0.1 -1.0 -0.4
Worrier / anxious feelings 3.1 5.9 20.3 -2.0 1.1 -0.9 -2.9 0.0 4.5 1.4 3.0 1.2 3.5
Frequency of tiredness / lethargy in last 2 weeks 2.1 3.4 20.0 -0.0 1.8 -0.1 -0.7 0.0 4.5 1.6 1.6 -0.6 2.2
Falls in the last year 7.6 10.4 23.5 4.8 3.5 3.5 4.4 0.0 1.3 3.6 -2.8 -3.1 -1.8
Hair/balding pattern: Pattern 3 0.4 0.6 1.5 -0.3 0.9 1.2 -0.5 0.0 -0.6 0.9 -0.9 0.5 -0.9
Number of live births 1.7 2.5 8.6 1.0 2.3 -0.7 0.6 0.0 2.9 0.9 1.8 -0.3 2.2
Forced expiratory volume in 1-second (FEV1) 1.1 3.6 9.9 -1.4 -2.7 -2.3 -1.3 0.0 -2.0 -3.1 1.1 1.7 1.3
Pulse rate 0.2 0.3 1.2 0.0 -0.8 -0.7 0.4 0.0 -0.3 -1.1 -0.0 -0.6 0.2
Happiness 0.6 0.7 1.6 -1.1 1.3 -0.9 -0.7 0.0 0.7 -0.1 1.0 0.8 0.6
Noisy workplace 5.7 7.0 17.7 4.2 3.5 2.4 3.6 0.0 2.7 2.8 -1.7 -1.7 -0.4
Qualifications: A levels/AS levels or equivalent 0.6 1.2 5.1 -1.1 -0.3 -1.2 -0.3 0.0 -2.3 -1.8 0.2 0.5 -0.9
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.9 0.7 0.8 0.5 -0.0 0.0 0.4 0.8 0.3 -0.9 0.8
Mouth/teeth dental problems: Dentures 2.2 3.6 17.4 0.7 2.2 0.7 -0.8 0.0 4.2 2.1 1.3 -1.3 2.2
Asthma 1.2 2.4 6.0 2.1 2.2 1.9 1.5 0.0 0.7 2.4 -0.9 -0.7 -1.0
Medication: Ibuprofen (e.g. Nurofen) 5.4 6.8 15.2 3.7 3.9 2.3 3.7 0.0 1.6 2.4 -2.4 -1.3 -2.0
Medication: Cholesterol lowering 4.7 7.3 20.9 4.6 2.5 2.7 3.9 0.0 0.6 2.7 -2.5 -2.7 -1.4
Depression (self-reported) 1.1 1.3 2.0 -1.0 -0.4 -1.4 -0.9 0.0 -1.4 -1.4 1.2 1.3 1.3
Medication: Lansoprazole 2.1 2.4 7.5 0.8 2.7 1.4 1.0 0.0 2.5 2.1 -0.7 -1.3 -0.8
Prospective memory result 0.5 0.6 2.0 0.3 1.4 0.4 1.1 0.0 0.4 0.5 -0.5 -1.0 -0.9
Lung cancer (father) 0.3 0.3 1.0 -0.6 -0.0 0.6 -0.0 0.0 0.5 -0.2 -1.0 -0.7 -0.7
Illnesses of mother 1.2 1.5 5.1 -2.2 -0.1 -1.1 -1.8 0.0 0.4 -1.4 1.0 1.4 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.9 6.0 14.5 -2.0 -3.0 -3.0 -2.2 0.0 -2.2 -3.8 1.8 2.7 1.8
Pulse wave Arterial Stiffness index 2.7 3.2 9.5 1.4 1.9 1.6 3.1 0.0 -0.0 0.7 -2.2 -2.5 -1.6
Impedance of arm (left) 4.9 22.6 46.6 -6.8 -6.8 -3.5 -4.7 0.0 -6.0 -6.3 0.5 4.6 -1.5
Arm fat mass (right) 1.6 6.6 16.6 4.1 2.2 2.3 3.1 0.0 3.3 3.2 -1.1 -2.7 -0.0
Trunk predicted mass 0.2 1.0 4.6 2.1 -0.2 -0.9 1.6 0.0 -0.1 -0.6 0.6 -0.3 1.0
Standing height 3.9 38.3 96.6 -6.3 -9.3 -6.6 -4.3 0.0 -7.6 -9.8 2.5 5.7 1.2
Length of working week for main job 0.3 0.4 0.9 -0.9 -0.5 -0.6 -0.9 0.0 0.4 -0.3 1.0 -0.5 0.3
Exposure to tobacco smoke at home 1.0 1.1 4.2 -0.2 0.8 -0.7 -0.5 0.0 1.5 0.0 1.6 0.5 2.1
Breastfed as a baby 1.5 1.8 5.3 1.9 1.1 1.5 1.7 0.0 -0.4 1.4 -1.1 -2.3 0.0
Tense / ‘highly strung’ 5.0 8.2 16.2 -3.2 -0.4 -3.0 -3.7 0.0 1.4 -1.6 3.8 3.8 4.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 3.8 -2.0 0.1 -1.0 -1.2 0.0 -0.4 -1.2 0.6 1.5 0.5
Hair/balding pattern: Pattern 4 0.9 2.2 6.8 1.1 1.6 0.3 0.5 0.0 2.6 2.0 0.9 -2.4 1.1
Birth weight of first child 4.7 8.5 16.8 -2.8 -3.9 -3.6 -2.8 0.0 -1.6 -4.1 2.6 3.5 1.9
Peak expiratory flow (PEF) 1.0 2.3 5.9 -1.4 -2.4 -1.5 -1.2 0.0 -1.8 -2.4 0.7 1.4 0.6
Pulse wave reflection index 2.3 2.8 6.6 1.5 2.6 1.9 2.3 0.0 0.3 1.6 -1.9 -1.0 -1.8
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.5 0.5 0.5 -0.7 0.9 0.0 0.5 -0.4 0.4 1.2 0.3
Loud music exposure frequency 0.5 0.6 2.8 -0.9 0.7 0.0 -0.6 0.0 1.7 0.8 0.5 -0.7 -0.0
Qualifications: O levels/GCSEs or equivalent 1.1 1.8 5.6 -1.8 -1.1 -1.6 -0.8 0.0 -2.4 -1.8 0.6 0.2 -0.8
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 2.8 0.7 1.1 1.2 0.6 0.0 -0.3 1.4 -1.1 -0.6 -1.7
Blood clot in the leg (DVT) 1.0 1.3 4.9 1.9 1.2 0.7 2.2 0.0 0.1 0.7 -0.9 -0.6 -0.6
Medication: Paracetamol 3.2 5.3 8.0 2.8 2.8 2.3 2.5 0.0 2.0 2.8 -2.1 -2.5 -1.9
Headache pain in last month 2.3 3.9 12.7 -0.9 0.6 -1.4 -2.1 0.0 3.6 -0.1 2.4 2.5 2.6
Medication for cholesterol, blood pressure or diabetes 2.4 3.9 11.5 -3.4 -1.8 -1.8 -2.9 0.0 -0.8 -2.1 1.5 2.1 0.9
Glaucoma (self-reported) 0.6 0.7 1.8 -0.9 -1.1 -1.0 -0.7 0.0 -0.3 -1.3 0.3 1.0 -0.2
Gout (self-reported) 1.5 2.1 4.0 1.6 2.0 1.6 1.7 0.0 1.3 1.6 -1.2 -1.2 -1.2
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.4 -1.2 -1.0 -0.9 -0.5 0.0 -1.2 -0.7 0.2 0.5 0.2
Medication: Amlodipine 0.5 0.7 2.5 0.3 0.5 -0.5 -0.6 0.0 1.6 0.2 1.2 -0.7 1.3
Medication: Ventolin 100micrograms inhaler 0.7 0.8 3.6 1.1 1.1 1.0 0.1 0.0 1.0 1.9 0.0 -0.6 -0.3
Birth weight 1.1 2.4 6.2 -2.0 -2.5 -1.7 -1.5 0.0 -1.4 -2.3 0.7 0.5 0.5
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.9 0.1 0.9 0.5 -0.3 0.0 1.4 0.9 0.2 0.1 0.9
High blood pressure (siblings) 0.3 0.4 1.9 0.5 0.1 -0.6 0.6 0.0 1.4 -0.6 0.6 -0.1 0.8
Forced vital capacity (FVC), Best measure 1.3 4.8 11.0 -1.7 -2.3 -2.7 -2.0 0.0 -2.0 -3.3 1.9 2.6 1.8
Body fat percentage 1.5 6.1 12.6 3.6 1.8 2.5 3.1 0.0 3.1 3.1 -1.6 -2.6 -0.6
Leg fat percentage (right) 4.2 15.2 32.8 5.7 3.6 4.0 4.8 0.0 3.7 5.3 -2.4 -4.3 -1.2
Arm fat-free mass (right) 0.5 2.7 11.6 3.4 1.2 0.3 2.7 0.0 1.5 0.9 0.0 -1.5 1.0
Exposure to tobacco smoke outside home 1.6 2.2 4.9 1.8 1.9 1.8 1.4 0.0 1.6 2.2 -0.6 -1.3 0.7
Comparative body size at age 10 1.5 4.0 8.8 2.2 1.4 2.7 2.3 0.0 -1.7 1.8 -3.0 -0.6 -2.4
Number of full brothers 0.7 0.8 2.2 -0.5 -0.7 -1.1 -0.6 0.0 -0.2 -1.2 1.0 1.1 1.5
Worry too long after embarrassment 2.0 3.3 9.7 -2.5 -0.0 -0.3 -3.1 0.0 2.2 0.6 1.8 1.3 2.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 3.5 -1.3 -0.7 -0.8 -1.0 0.0 -1.9 -0.9 0.6 1.4 0.2
Wheeze or whistling in the chest in last year 2.3 4.1 11.5 3.4 2.9 1.9 2.5 0.0 1.3 2.8 -0.8 -1.1 -0.4
Number of children fathered 1.5 1.7 3.7 0.9 -0.5 -1.5 -0.7 0.0 0.8 -1.4 1.7 1.9 1.9
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.6 4.6 -2.1 -1.5 -2.0 -2.0 0.0 -0.1 -1.5 2.2 1.1 1.7
Age at first live birth 0.4 0.8 2.0 -1.4 -1.3 -1.1 -0.6 0.0 -0.5 -1.4 0.2 0.1 -0.3
Pulse wave peak to peak time 3.8 4.4 11.6 -1.8 -2.4 -2.0 -3.4 0.0 -0.6 -1.3 2.4 3.1 1.6
Health satisfaction 2.4 3.2 12.4 0.7 3.1 1.2 0.9 0.0 3.5 2.4 -0.1 -0.9 -0.2
Shortness of breath walking on level ground 0.9 1.1 2.2 0.9 0.9 0.7 1.3 0.0 1.5 1.2 -0.6 -1.2 -1.1
Qualifications: College or University degree 0.4 1.3 4.2 -1.6 -0.4 -0.6 -0.8 0.0 -2.0 -1.1 -0.0 1.6 -1.3
Eye problems/disorders: None of the above 1.3 1.5 3.6 -0.9 -1.9 -1.3 -0.9 0.0 -0.9 -1.9 1.0 1.0 1.2
Mouth/teeth dental problems: Loose teeth 0.2 0.2 1.1 -0.1 0.6 -0.1 0.2 0.0 1.0 0.2 0.4 0.1 0.1
Emphysema/chronic bronchitis 1.3 1.4 3.6 1.9 1.0 1.2 1.4 0.0 -1.6 1.2 -0.9 0.9 -0.8
Medication for pain relief, constipation, heartburn 5.7 9.8 18.8 -4.3 -3.7 -3.3 -4.0 0.0 -1.9 -3.6 3.0 2.3 2.8
Neck or shoulder pain in last month 3.8 5.5 11.8 3.4 3.2 2.2 2.7 0.0 2.7 2.6 -1.8 -1.5 -1.2
Medication: Blood pressure 0.1 0.2 0.5 0.7 -0.5 0.1 0.5 0.0 -0.1 0.0 -0.1 -0.7 -0.0
Angina (self-reported) 2.4 3.2 8.0 2.5 2.8 1.5 1.3 0.0 2.7 2.5 -0.3 -0.5 0.3
Migraine (self-reported) 0.4 0.5 1.7 -0.4 -1.2 -0.7 -0.2 0.0 0.3 -1.3 0.6 0.9 0.6
Medication: Ibuprofen 5.5 6.6 14.6 3.5 3.8 2.4 3.6 0.0 1.7 2.5 -2.3 -1.3 -2.0
Medication: Allopurinol 0.5 0.7 2.4 0.8 1.0 1.3 0.3 0.0 0.6 1.6 -0.7 -0.2 -0.6
Medication: Omeprazole 0.1 0.2 0.9 -0.2 -0.8 -0.1 0.2 0.0 -0.9 0.3 0.1 0.0 -0.1
Medication: Seretide 50 evohaler 1.6 1.8 3.2 1.8 1.2 1.5 1.6 0.0 0.3 1.2 -1.5 -1.5 -1.5
Mean time to correctly identify matches 0.9 1.7 5.9 -2.4 0.6 -0.6 -2.4 0.0 1.0 0.3 1.4 0.3 1.2
Heart disease (mother) 2.5 3.1 8.8 3.0 1.2 1.8 2.5 0.0 0.9 2.6 -1.1 -1.3 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 2.4 1.0 1.6 0.2 0.5 0.0 0.2 0.1 -0.3 0.3 0.0
Whole body fat mass 1.4 5.7 14.9 3.9 1.7 2.1 3.4 0.0 2.9 2.6 -1.3 -2.6 -0.2
Leg fat mass (right) 2.7 10.6 25.8 5.1 3.0 2.9 4.2 0.0 3.7 4.0 -1.6 -3.6 -0.2
Arm predicted mass (right) 0.5 2.5 11.8 3.4 1.0 0.2 2.6 0.0 1.5 0.8 0.1 -1.2 1.1
Pulse rate, automated reading 0.6 1.9 5.3 2.2 0.6 0.9 2.3 0.0 0.5 0.6 -1.5 -1.9 -0.9
Alcohol intake frequency. 0.2 0.5 3.2 -0.9 0.3 0.2 -0.4 0.0 1.8 0.6 -0.1 -0.7 -0.1
Comparative height size at age 10 2.1 11.3 36.1 -2.5 -5.5 -2.8 -0.9 0.0 -6.0 -4.8 -0.1 2.6 -1.3
Number of full sisters 0.8 1.0 3.7 -0.2 -0.2 -1.2 -0.5 0.0 0.0 -1.3 1.6 0.1 1.9
Suffer from ‘nerves’ 4.4 7.0 12.4 -2.5 -1.9 -3.0 -3.1 0.0 -0.6 -2.8 3.0 3.5 3.4
Overall health rating 4.1 8.9 26.7 2.4 4.3 2.6 2.1 0.0 5.2 4.1 -1.4 -2.3 -1.3
Chest pain or discomfort 3.5 5.1 14.2 2.3 3.5 2.6 1.6 0.0 2.7 3.8 -0.9 -1.1 -0.1
Had major operations 1.1 1.3 4.3 0.2 1.0 1.5 1.0 0.0 -0.4 0.2 -2.0 0.1 -2.1
Age at last live birth 1.0 1.4 4.7 -2.2 -1.0 -1.5 -1.4 0.0 1.2 -1.0 1.2 -0.2 0.4
Family relationship satisfaction 0.7 0.8 5.1 -0.2 2.2 0.2 0.9 0.0 1.1 0.5 -0.3 0.2 -0.8
Leg pain on walking 0.9 1.1 6.0 0.2 1.3 0.2 0.1 0.0 2.4 1.1 0.6 0.1 1.3
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.2 6.3 2.5 1.5 1.0 2.1 0.0 1.2 1.5 -0.6 -2.0 0.1
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.4 1.0 1.2 0.0 0.8 0.0 1.4 0.7 0.2 -1.6 0.1
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.9 0.4 1.0 0.3 0.2 0.0 0.5 0.9 0.2 -0.0 -0.3
Medication: Aspirin 4.7 6.2 15.2 3.9 2.7 2.6 3.1 0.0 1.8 3.2 -1.9 -1.8 -1.7
Supplements: Vitamin C 0.5 0.6 2.4 0.4 0.2 -0.5 -0.6 0.0 1.5 -0.4 1.2 0.5 1.2
Knee pain experienced in last month 1.1 1.7 6.5 1.5 1.6 0.7 0.8 0.0 2.5 1.7 0.6 0.4 1.2
Hypertension (Self-reported) 2.0 5.6 17.7 4.2 2.1 2.0 3.6 0.0 1.2 2.3 -1.7 -2.3 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.3 -0.5 1.1 -0.0 -0.0 0.0 0.3 0.5 0.1 0.8 -0.8
Illnesses of father: Heart disease 3.9 5.4 17.3 4.2 2.4 2.2 3.1 0.0 1.8 3.0 -1.5 -1.4 -0.6
Illnesses of siblings: Diabetes 3.6 4.4 9.7 2.7 2.1 1.9 3.1 0.0 2.0 2.2 -1.4 -2.8 -0.7
Smoking status: Previous 0.8 1.2 2.4 1.3 0.9 0.6 1.5 0.0 -0.6 0.7 -1.0 -1.5 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.4 11.9 -2.3 -2.7 -3.1 -1.4 0.0 -0.9 -3.5 1.6 1.8 1.0
Whole body fat-free mass 0.2 1.4 6.9 2.6 0.3 -0.4 2.1 0.0 0.7 -0.1 0.3 -0.9 1.1
Leg fat-free mass (right) 0.3 1.5 6.0 2.5 0.5 -0.1 2.1 0.0 1.4 0.2 0.1 -1.3 0.8
Arm fat percentage (left) 2.2 8.6 18.1 4.3 2.6 3.0 3.4 0.0 3.6 3.9 -1.6 -3.1 -0.7
Average weekly red wine intake 1.5 2.2 6.8 -2.1 -1.5 -1.4 -1.2 0.0 -2.6 -1.8 0.7 1.1 0.3
Handedness (chirality/laterality): Left-handed 1.8 2.2 4.6 -1.4 -1.9 -1.5 -1.3 0.0 -2.1 -1.6 1.1 1.9 0.3
Mood swings 0.6 1.1 4.5 0.4 1.7 0.6 -0.2 0.0 1.1 1.0 0.6 0.5 2.1
Loneliness, isolation 1.0 1.3 4.0 -0.4 2.0 0.1 -0.7 0.0 1.7 1.0 0.9 0.6 1.8
Long-standing illness, disability or infirmity 4.2 6.5 12.2 3.0 3.1 2.4 2.6 0.0 3.5 3.3 -1.1 -2.8 -1.1
Ever had bowel cancer screening 0.3 0.4 1.8 -0.6 0.1 0.4 -0.6 0.0 -0.9 0.3 -0.2 1.4 0.2
Diabetes diagnosed by doctor 3.9 6.4 13.6 2.4 3.1 2.9 2.1 0.0 3.2 3.7 -1.8 -2.5 -1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.9 0.8 0.1 -0.3 1.0 0.0 -0.3 -0.4 0.2 0.1 0.2
Friendships satisfaction 0.5 0.6 3.0 -0.5 1.2 0.3 -0.1 0.0 1.7 0.7 -0.2 -0.5 -0.7
Qualifications: nursing, teaching 0.8 1.3 3.2 1.8 1.3 0.8 1.6 0.0 0.7 1.2 -0.6 -1.2 -1.0
Commuting to job workplace: Walk 0.4 0.5 2.4 -0.4 -0.4 -0.5 -0.2 0.0 -1.6 -0.9 0.0 0.8 -0.2
Eye problems/disorders: Cataract 0.4 0.5 1.6 0.4 0.5 -0.6 0.1 0.0 -0.9 -0.1 0.9 1.0 1.3
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 3.4 1.2 1.8 0.1 0.3 0.0 1.5 1.1 1.1 0.3 1.6
Medication for cholesterol 1.4 2.1 6.8 -2.6 -1.2 -1.5 -1.9 0.0 -0.7 -1.8 1.2 1.1 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 0.3 0.3 0.1 0.5 0.0 0.2 0.2 -0.2 -0.4 -0.5
Back pain experienced in last month 1.0 1.4 4.6 0.6 -0.1 -1.1 -1.0 0.0 1.2 -0.1 2.0 1.3 2.1
Mineral and other dietary supplements 1.2 1.6 3.0 1.4 1.1 1.3 1.3 0.0 0.1 1.6 -1.4 -1.7 -1.3
Breast cancer (self-reported) 0.1 0.2 0.6 0.4 0.1 0.6 0.2 0.0 -0.2 0.3 -0.8 -0.7 -0.2
Asthma (self-reported) 1.6 3.3 7.2 2.3 2.5 2.2 1.8 0.0 1.0 2.7 -1.3 -1.1 -1.3
Osteoporosis (self-reported) 0.3 0.4 2.3 0.3 0.6 0.0 -0.3 0.0 1.5 0.1 0.7 -0.5 0.7
Osteoarthritis (self-reported) 1.1 1.4 3.8 1.0 1.8 1.3 0.9 0.0 2.0 1.8 -0.3 -0.5 0.0
Medication: Aspirin 4.8 6.2 16.7 4.1 2.5 2.6 3.2 0.0 1.7 3.2 -1.8 -1.8 -1.6
Medication: Gliclazide 0.4 0.5 2.0 0.3 0.7 0.8 0.4 0.0 1.1 1.4 -0.4 -0.0 -0.4
Illnesses of father: None of the above (group 1) 5.7 7.1 14.0 -3.5 -2.6 -2.5 -3.7 0.0 -1.7 -3.7 2.0 2.6 2.1
Smoking status: Current 0.4 0.6 1.7 -0.3 1.3 0.7 0.3 0.0 1.3 0.9 -0.6 -0.7 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.4 -0.1 -1.1 -1.1 -0.8 0.0 -1.6 -1.1 0.9 1.0 0.6
Whole body water mass 0.2 1.3 6.1 2.5 0.3 -0.6 1.9 0.0 0.7 -0.2 0.5 -0.7 1.2
Leg predicted mass (right) 0.3 1.5 5.9 2.4 0.5 -0.1 2.1 0.0 1.4 0.2 0.1 -1.3 0.9
Arm fat mass (left) 1.7 6.8 17.7 4.2 2.2 2.2 3.2 0.0 3.3 3.3 -1.0 -2.7 0.0
Number of self-reported non-cancer illnesses 0.8 1.4 4.0 2.0 1.9 0.5 1.6 0.0 1.4 1.2 0.0 -0.2 -0.4
Average weekly champagne plus white wine intake 0.6 0.8 2.7 -0.0 -0.4 0.8 0.8 0.0 -1.3 -0.4 -1.4 -0.3 -1.6
Miserableness 1.7 2.9 10.5 0.1 2.5 0.7 -0.4 0.0 3.2 1.9 1.0 -0.9 2.5
Guilty feelings 0.7 1.1 2.4 -1.5 0.7 0.1 -1.6 0.0 1.5 0.3 0.5 1.3 1.2
Wears glasses or contact lenses 0.1 0.1 0.4 -0.0 0.3 0.1 -0.2 0.0 -0.3 0.4 0.4 0.6 0.4
Ever taken oral contraceptive pill 0.7 0.8 2.7 1.6 0.9 0.5 1.5 0.0 0.1 0.6 -0.6 -1.3 -0.2
Hearing aid user 1.3 1.4 3.7 1.5 0.4 1.4 1.9 0.0 -1.1 0.7 -1.6 -0.0 -1.4
Mother’s age at death 1.7 2.2 5.8 -2.4 -2.2 -1.6 -1.8 0.0 -0.9 -1.4 1.2 1.0 0.5
Financial situation satisfaction 0.6 0.8 2.4 -0.9 0.3 -0.8 -1.1 0.0 0.6 -0.4 1.1 0.9 1.6
Tinnitus: Yes, now most or all of the time 2.2 2.5 4.6 -1.8 -2.1 -1.6 -2.1 0.0 -1.0 -1.6 1.7 1.3 1.6
Commuting to job workplace: Public transport 0.6 0.8 1.9 0.5 0.7 0.9 1.2 0.0 -1.4 0.4 -1.2 0.6 -1.0
Eye problems/disorders: Glaucoma 0.2 0.2 0.5 -0.7 -0.7 -0.4 -0.7 0.0 -0.2 -0.5 -0.0 0.2 -0.6
Medication: Blood pressure 1.8 3.4 9.9 3.1 0.7 1.8 3.0 0.0 -0.7 1.3 -2.0 -1.7 -1.6
Pain type(s) experienced in last month: Hip pain 3.2 4.0 15.8 1.8 4.0 1.4 1.4 0.0 3.1 2.5 -0.5 -0.7 -0.8
Supplements: Fish oil (including cod liver oil) 1.0 1.4 2.2 -1.1 -1.3 -1.1 -1.4 0.0 -0.2 -1.2 1.4 1.3 1.5
High cholesterol (Self-reported) 2.0 3.6 14.8 3.8 1.1 1.6 2.7 0.0 0.9 2.1 -1.0 -2.0 0.2
Medication: Bendroflumethiazide 0.6 1.0 3.5 1.7 -0.5 0.4 1.9 0.0 -1.0 0.0 -0.9 -0.9 -0.4
Medication: Paracetamol 4.8 7.4 11.0 3.3 2.8 2.9 3.3 0.0 1.4 3.1 -2.7 -3.1 -2.6
Medication: Lisinopril 0.7 0.9 4.7 1.4 -1.0 0.4 0.7 0.0 -2.2 0.0 -0.6 0.3 -0.4
Medication: Atorvastatin 1.9 2.3 7.2 2.7 1.9 1.4 1.9 0.0 1.5 1.6 -0.9 -1.1 0.0
Illnesses of father: High blood pressure 0.3 0.3 1.9 0.1 0.2 -0.7 0.5 0.0 1.4 -0.3 0.4 0.2 0.5
Alcohol drinker status: Never 0.2 0.2 0.8 -0.4 0.5 0.1 -0.8 0.0 0.9 -0.0 0.1 0.1 0.6
Ever smoked 1.1 2.0 4.9 0.9 1.5 1.1 1.7 0.0 -0.7 0.8 -1.7 -2.2 -2.0
Basal metabolic rate 0.3 1.9 9.0 3.0 0.6 -0.0 2.4 0.0 1.1 0.4 0.0 -1.3 0.9
Leg fat percentage (left) 4.0 14.3 29.7 5.5 3.7 3.7 4.5 0.0 4.2 5.2 -2.0 -4.1 -0.8
Arm fat-free mass (left) 0.3 1.7 6.9 2.6 0.8 -0.2 1.8 0.0 1.5 0.7 0.6 -0.9 1.5
Number of operations (self-reported) 1.1 1.6 4.4 1.2 0.9 1.5 1.5 0.0 -0.8 0.9 -1.8 0.3 -2.1
Average weekly beer plus cider intake 2.2 3.2 13.4 1.7 2.2 0.7 1.2 0.0 3.7 1.8 0.5 -1.4 1.9
Irritability 0.7 1.2 5.5 -0.2 1.7 -0.4 0.2 0.0 2.4 -0.4 0.7 0.7 1.6
Risk taking 3.8 5.5 14.5 3.7 2.5 2.2 3.8 0.0 -0.7 1.5 -2.5 -1.5 -2.3
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.5 -0.6 0.5 -0.4 -1.1 0.0 1.2 0.3 1.2 -0.4 0.7
Fractured/broken bones in last 5 years 0.3 0.3 1.4 -1.2 0.2 -0.7 -0.3 0.0 0.6 -0.7 0.5 -0.5 0.3
Age started oral contraceptive pill 2.7 3.4 9.2 -2.2 -3.0 -0.3 -1.8 0.0 -3.0 -2.1 -0.6 1.5 -0.7
Diastolic blood pressure, automated reading 0.3 0.8 2.3 1.1 -0.2 -1.0 1.5 0.0 1.0 -0.9 0.5 -0.3 1.2
Ever depressed for a whole week 1.4 1.8 4.9 0.0 1.3 1.7 1.1 0.0 -1.0 1.1 -2.1 -0.2 -2.2
Unable to work because of sickness or disability 0.4 0.5 1.6 1.1 1.1 -0.6 1.3 0.0 0.6 -0.2 0.4 0.5 0.3
Commuting to job workplace: Cycle 5.6 6.7 12.7 2.2 2.9 3.5 2.5 0.0 0.5 3.6 -2.8 -2.6 -2.7
Myopia 1.4 2.0 5.0 -1.5 -1.2 -2.2 -0.8 0.0 -0.2 -1.7 1.8 1.5 1.4
Vascular/heart problems diagnosed by doctor 2.7 7.4 24.4 -4.9 -2.5 -2.3 -4.0 0.0 -1.6 -2.7 1.8 2.7 1.3
Cholesterol lowering medication 2.1 3.0 12.2 3.5 1.1 1.7 2.3 0.0 1.0 2.1 -0.9 -1.6 0.2
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 1.7 -0.5 -0.4 0.2 -0.2 0.0 -1.3 0.4 -0.0 0.2 -0.1
Pain experienced in last month 2.5 4.1 19.3 -1.9 -3.0 -1.1 -1.0 0.0 -4.4 -2.4 -0.1 1.0 -0.7
Supplements: Calcium 2.2 2.4 4.6 -2.0 -0.2 -2.1 -2.0 0.0 1.2 -1.4 2.1 1.3 1.3
Basal cell carcinoma (self-reported) 0.9 1.1 2.0 -1.4 -1.0 -1.1 -1.3 0.0 -0.2 -1.0 1.3 0.5 1.3
Heart attack/myocardial infarction (self-reported) 6.9 8.9 26.4 5.1 3.2 3.0 4.2 0.0 1.2 3.2 -2.4 -2.3 -1.6
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 3.8 1.7 1.2 0.7 2.0 0.0 -0.2 0.6 -0.9 -0.3 -0.6
Heart disease (siblings) 2.4 3.0 5.3 2.3 1.5 2.1 2.3 0.0 1.3 2.1 -1.4 -1.7 -1.0
Alcohol drinker status: Previous 0.4 0.4 1.1 -1.0 0.5 0.2 -0.2 0.0 1.0 0.7 0.5 -1.1 0.4
Pack years of smoking 1.3 1.9 7.7 2.8 1.7 1.3 1.4 0.0 0.7 1.9 -0.5 0.1 0.2
Impedance of whole body 4.1 20.8 43.8 -6.6 -6.5 -3.5 -4.6 0.0 -5.4 -6.0 0.8 4.6 -1.0
Leg fat mass (left) 2.5 9.7 23.1 4.8 2.9 2.7 3.9 0.0 3.9 3.9 -1.3 -3.4 0.1
Arm predicted mass (left) 0.4 1.8 7.2 2.7 0.8 -0.0 2.0 0.0 1.6 0.8 0.4 -1.1 1.4