Hub : Genes

RP11-78I14.1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0972	0.0399	0.0028	0.080	NA	0.069	NA	0.060	7.3e-07	NA	4.2e-06	NA	1.8e-05
2	GTEx	Lung	0.1514	0.0529	0.0029	-0.002	NA	0.009	NA	-0.003	5.4e-01	NA	6.7e-02	NA	6.9e-01
3	GTEx	Skin Sun Exposed Lower leg	0.1370	0.0500	0.0062	0.063	NA	0.035	NA	0.034	6.0e-06	NA	6.0e-04	NA	7.1e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.7	1.8	1.3	-0.5	-0.0
Bipolar Disorder or Schizophrenia	1.2	2.9	6.4	1.6	-2.5	-0.2
Depressed Affect (Nagel 2018)	0.4	0.9	1.4	-1.2	0.8	-0.8
Depression (Nagel 2018)	0.1	0.1	0.4	-0.0	-0.6	-0.1
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.2	-0.8	-1.5	-0.9
Neuroticism (Nagel 2018)	0.4	1.0	2.2	-1.5	0.4	-0.8
Schizophrenia (2018)	1.4	3.0	8.0	0.9	-2.8	-0.2
Schizophrenia vs Biploar Disorder	0.2	0.2	0.7	-0.1	-0.8	0.2
Worry (Nagel 2018)	0.3	0.7	1.2	-0.7	0.6	-1.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.8	0.1	-1.3	0.0
Alzheimer’s Disease (in father)	1.7	1.8	2.2	1.5	1.2	1.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	0.2	0.5	0.5
Crohns Disease (2017)	0.2	0.4	0.5	0.7	-0.5	0.6
Irritable Bowel Disease (IBD)	0.4	1.0	1.6	1.1	-0.5	1.3
Ulcerative Colitis (UC)	0.3	0.5	1.5	0.3	0.1	1.2
Major Depression (MDD)	0.3	0.4	0.8	0.9	-0.3	0.5
Reaction Time	1.4	2.7	5.5	0.8	-2.3	1.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.1	0.3	-1.0	-1.5
Breast Cancer	0.0	0.1	0.2	-0.3	-0.4	0.2
Ovarian Cancer	0.0	0.0	0.0	-0.2	-0.1	0.2
Prostate Cancer	2.5	3.5	6.6	-2.6	-1.8	-1.0
Age at First Birth	1.1	1.6	3.3	-1.8	-0.1	-1.2
Bipolar Disorder (2011)	2.8	2.7	5.2	2.3	-1.0	1.4
Body Mass Index (BMI) (2010)	0.8	1.0	2.5	-1.6	-0.4	-0.7
Coronary Artery Disease (CAD)	1.4	1.7	3.9	0.7	0.7	2.0
Crohns Disease (2012)	0.7	1.1	2.1	1.4	-0.2	1.1
Mean Putamen Volume	2.0	2.3	5.7	-1.1	0.2	-2.4
Fasting Glucose	0.5	0.6	1.1	-1.0	0.1	0.8
HbA1C	1.3	1.4	3.0	0.2	1.7	1.1
HDL Cholesterol	2.3	3.8	10.4	0.1	-1.0	-3.2
LDL Cholesterol	2.3	3.6	4.7	-2.2	1.3	-2.1
Lupus	0.5	0.8	2.2	0.1	-1.5	-0.2
Neuroticism (2016)	0.3	0.4	0.8	0.9	0.3	0.6
Primary Biliary Cirrhosis	0.5	0.7	1.6	0.4	1.3	0.6
Rheumatoid Arthritis	0.4	0.5	1.4	-1.2	-0.0	0.4
Schizophrenia (2014)	1.7	3.6	5.1	2.2	-2.3	0.9
Triglycerides	1.0	1.6	2.4	-0.8	1.6	1.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.9	0.5	-0.0	1.4
Ulcerative Colitis	1.5	2.1	3.4	1.8	0.8	1.5
Blood Eosinophil Count	0.5	3.5	9.7	-0.1	-3.1	0.9
Blood Platelet Count	0.6	6.8	9.7	3.1	-2.4	2.2
Blood Red Count	0.1	1.2	1.9	-0.7	-1.4	-1.0
Blood White Count	0.4	2.7	4.6	1.0	1.5	2.1
Heel T-Score	0.5	3.8	5.9	2.0	1.2	2.4
BMI	1.0	5.7	11.7	-3.4	1.0	-2.1
Height	5.5	105.4	176.9	-13.3	-0.3	-11.8
Waist Hip Ratio (WHR)	0.1	0.5	0.6	0.7	-0.6	0.8
Systolic Blood Pressure	1.0	4.9	7.9	0.6	2.6	2.8
Smoking Status	0.0	0.0	0.0	0.2	0.2	-0.1
Allergy or Eczema	0.3	0.8	2.4	-1.5	-0.3	0.3
Cardiovascular Disease	1.0	3.2	7.7	-1.4	2.8	-0.1
Hypothyroidism (self reported)	0.3	0.7	1.5	0.5	0.6	1.2
Respiratory disease	0.7	1.5	2.4	-1.6	0.4	-1.4
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.4	0.1	1.6	0.4
Lung FEV1/FVC ratio	2.3	11.9	17.6	2.7	-3.2	4.2
Lung FVC	2.8	14.4	18.5	-4.3	-4.1	-2.8
Neuroticism	0.5	1.3	2.3	-0.7	1.5	-1.0
Chronotype (morning person)	1.0	2.2	3.3	1.5	-1.1	1.8
Hair Pigment	0.0	0.8	1.9	-0.3	-1.4	0.7
Tanning	0.0	0.6	0.9	0.9	-0.1	1.0
Hand grip strength (left)	0.1	0.3	0.7	0.2	0.5	-0.8
Number of treatments/medications taken	0.4	0.7	1.4	-1.2	0.9	0.3
Average weekly spirits intake	0.3	0.3	0.8	0.3	0.9	0.2
Sensitivity / hurt feelings	0.6	1.1	1.8	-1.2	-1.3	0.4
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.2	0.0	0.3
Hearing difficulty/problems: Yes	2.5	3.8	9.8	-1.0	0.9	-3.1
Relative age of first facial hair	0.6	1.2	1.8	-0.0	1.4	-1.3
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.1	-2.2	-0.9	-0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.4	0.7	-0.8	0.7	-0.3
Ever had hysterectomy (womb removed)	3.3	3.7	10.0	1.0	-3.2	0.4
Systolic blood pressure, automated reading	0.7	2.0	2.5	1.6	1.3	1.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	-0.3	1.1	0.1
Angina	2.1	2.8	4.8	1.6	-1.0	2.2
Medication for hormone replacement therapy	1.2	1.3	3.6	-1.9	0.4	-0.2
Vitamin and mineral supplements	0.4	0.5	1.0	0.2	-1.0	-0.7
Supplements: Zinc	0.6	0.6	1.1	0.3	0.8	-1.1
Medication: Co-codamol	0.8	0.9	2.2	-0.0	1.5	0.8
Medication: Metformin	1.3	1.8	3.2	-1.8	0.6	-1.3
Diabetes (father)	0.7	0.9	2.5	1.6	-0.1	0.4
Diabetes (mother)	1.1	1.4	3.6	-1.9	-0.4	-0.8
Severe depression (siblings)	0.1	0.1	0.2	0.4	-0.2	-0.5
Pack years adult smoking proportion	0.1	0.2	0.6	-0.8	-0.1	-0.1
Impedance of leg (right)	0.3	1.6	4.2	0.6	2.0	0.4
Leg fat-free mass (left)	4.5	23.7	46.5	-6.8	0.7	-4.9
Trunk fat percentage	3.8	15.3	30.0	-5.5	2.1	-3.4
Hand grip strength (right)	0.1	0.2	0.3	0.5	0.6	0.1
Townsend deprivation index at recruitment	0.5	0.6	0.8	0.9	0.7	0.8
Current tobacco smoking	0.2	0.3	0.5	-0.5	-0.1	0.7
Average weekly fortified wine intake	0.5	0.6	1.1	0.7	-0.3	1.1
Maternal smoking around birth	0.2	0.3	0.6	0.5	0.2	-0.7
Fed-up feelings	0.9	1.7	3.1	-1.4	1.8	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.4	0.7	0.2
Relative age voice broke	1.0	1.5	3.0	1.7	-0.6	1.1
Taking other prescription medications	1.3	2.0	4.2	-1.3	2.0	-0.3
Age when periods started (menarche)	1.0	2.3	3.9	-1.4	-1.0	-2.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.4	-1.2	-0.8	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	0.1	-0.5	0.7
Tinnitus: Yes, but not now, but have in the past	2.0	2.2	3.4	1.7	-1.8	0.3
Qualifications: CSEs or equivalent	0.8	1.0	2.1	-0.6	0.8	-1.4
Serious illness, injury or assault to yourself	0.2	0.2	0.3	-0.5	-0.4	-0.5
High blood pressure	0.4	1.0	1.5	-1.2	0.9	0.9
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.1	-1.8	-0.8	0.1
Multivitamins +/- minerals	1.0	1.3	3.3	-0.7	1.8	0.5
Stomach or abdominal pain in last month	1.1	1.4	3.4	0.2	0.8	1.8
Supplements: Glucosamine	0.7	0.9	1.3	1.1	0.1	-1.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.5	-0.6	-0.2	-1.9
Medication: Atenolol	0.2	0.2	0.3	-0.5	0.4	0.5
Medication: Levothyroxine sodium	1.1	1.8	4.0	0.7	0.9	2.0
Sitting height	3.5	24.7	46.4	-6.8	0.9	-5.2
Chronic bronchitis/emphysema (father)	1.0	1.2	2.7	-0.9	0.3	-1.6
High blood pressure (mother)	1.8	2.5	3.2	-1.4	-1.6	-1.8
Body mass index (BMI)	0.9	3.9	7.8	-2.8	1.6	-1.1
Impedance of leg (left)	0.2	0.8	1.2	1.1	1.1	0.4
Leg predicted mass (left)	4.5	23.9	46.9	-6.8	0.7	-4.9
Trunk fat mass	4.8	20.5	39.4	-6.3	2.2	-4.1
Waist circumference	2.6	9.6	20.4	-4.5	1.8	-2.3
Number of incorrect matches in round	1.3	2.1	4.3	1.4	-2.1	0.3
Past tobacco smoking	0.5	0.9	1.4	-1.2	-1.0	-0.6
Alcohol usually taken with meals	0.0	0.0	0.1	-0.3	-0.0	-0.1
Nervous feelings	0.1	0.2	0.3	-0.1	0.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.5	-0.1	1.6	1.4
Hearing difficulty/problems with background noise	0.7	1.1	2.5	0.7	1.6	0.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.2	0.6	-0.1
Had menopause	0.7	0.9	1.7	-1.3	-1.0	-0.1
Had other major operations	0.5	0.6	1.5	-0.3	1.2	0.6
Forced vital capacity (FVC)	7.0	27.0	47.7	-6.9	-1.4	-5.6
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.9	1.3	-0.3	1.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.8	-1.4	-0.2	-0.8
Qualifications: None of the above	0.0	0.1	0.1	0.4	0.1	-0.1
Financial difficulties in last 2 years	2.2	2.9	8.2	-2.9	0.7	0.1
Mouth/teeth dental problems	0.3	0.5	0.9	-0.7	-0.9	-0.1
Heart attack	0.4	0.5	1.3	-0.5	1.1	-0.3
Allergy	1.2	2.8	6.0	2.5	1.0	1.2
Pain all over the body in last month	1.6	1.7	2.1	-1.3	-1.1	-1.4
Diabetes (self-reported)	0.6	0.9	1.7	-0.7	1.3	-0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	-0.7	-0.4	-1.0
Medication: Ramipril	0.4	0.5	1.2	-0.5	-1.1	0.3
Medication: Simvastatin	0.2	0.3	0.9	-0.1	-0.2	1.0
Fluid intelligence score	1.2	2.4	5.6	-0.6	-2.4	-1.1
Illnesses of siblings	0.3	0.5	1.1	0.2	-0.6	-1.0
Neuroticism score	0.8	1.6	2.6	-1.6	1.1	-1.0
Weight	4.7	23.1	46.1	-6.8	2.1	-4.4
Impedance of arm (right)	1.6	7.2	12.0	-3.1	0.6	-3.5
Arm fat percentage (right)	2.7	10.7	19.9	-4.5	2.3	-2.7
Trunk fat-free mass	2.5	14.3	28.5	-5.3	0.7	-3.7
Hip circumference	4.3	18.5	32.8	-5.7	2.5	-4.1
Time employed in main current job	2.3	2.7	6.0	2.4	0.4	1.4
Alcohol intake versus 10 years previously	0.7	1.0	2.3	-1.5	-0.3	-0.8
Father’s age at death	1.9	2.5	4.1	-0.0	1.8	-2.0
Worrier / anxious feelings	0.6	1.1	2.5	-1.6	0.8	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.1	-0.2	0.1	0.2
Falls in the last year	0.5	0.6	1.7	0.4	-1.3	-0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.2	0.2	0.7
Number of live births	0.4	0.6	1.7	-0.1	-0.4	-1.3
Forced expiratory volume in 1-second (FEV1)	4.3	14.5	26.5	-5.2	-2.2	-3.5
Pulse rate	1.2	2.0	5.3	-0.3	-0.7	-2.3
Happiness	0.4	0.5	0.7	0.4	0.8	-0.8
Noisy workplace	1.0	1.3	2.8	-0.8	1.7	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.9	-0.3	0.0	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	0.8	-0.2	-0.7
Mouth/teeth dental problems: Dentures	0.5	0.9	2.0	0.7	1.4	0.4
Asthma	0.1	0.2	0.5	-0.4	0.0	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.8	-0.9	0.3	-0.8
Medication: Cholesterol lowering	0.5	0.8	1.3	-1.1	0.2	1.0
Depression (self-reported)	2.5	2.9	7.4	0.1	2.7	-1.2
Medication: Lansoprazole	1.3	1.5	3.1	-1.1	-1.8	0.1
Prospective memory result	0.6	0.8	2.0	0.0	-1.4	-0.5
Lung cancer (father)	2.0	2.3	3.8	-2.0	-0.5	-1.7
Illnesses of mother	1.6	1.9	2.3	1.5	1.4	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	4.8	15.2	31.0	-5.6	-1.8	-3.4
Pulse wave Arterial Stiffness index	1.1	1.2	2.6	0.9	1.6	-0.6
Impedance of arm (left)	1.6	7.3	11.8	-3.2	0.1	-3.4
Arm fat mass (right)	3.6	14.8	29.7	-5.5	2.0	-3.3
Trunk predicted mass	2.4	13.9	27.4	-5.2	0.7	-3.7
Standing height	4.8	48.1	83.5	-9.1	1.0	-7.7
Length of working week for main job	0.6	0.7	1.0	0.3	0.9	1.0
Exposure to tobacco smoke at home	0.2	0.2	0.3	0.3	-0.5	-0.6
Breastfed as a baby	1.4	1.8	3.1	1.8	1.5	-0.1
Tense / ‘highly strung’	0.3	0.6	1.0	-0.6	-1.0	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	5.4	-1.2	-0.1	-2.3
Hair/balding pattern: Pattern 4	0.7	1.6	2.0	1.2	1.4	1.2
Birth weight of first child	6.4	11.6	19.1	-4.4	-1.6	-3.6
Peak expiratory flow (PEF)	2.2	5.0	13.8	-3.7	-0.1	-1.1
Pulse wave reflection index	0.9	1.1	2.7	0.7	1.6	-0.1
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.5	-0.9	1.2	-0.4
Loud music exposure frequency	1.8	2.0	4.1	2.0	0.3	1.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.7	-0.4	-1.3	-0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	0.3	0.3	0.6
Blood clot in the leg (DVT)	0.5	0.6	1.4	-1.2	0.3	-0.6
Medication: Paracetamol	0.4	0.7	1.8	-1.4	0.3	-0.3
Headache pain in last month	0.9	1.6	3.1	-1.8	1.1	-0.6
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.7	1.1	0.2	-1.3
Glaucoma (self-reported)	0.8	1.0	2.2	0.5	-0.7	1.5
Gout (self-reported)	0.3	0.4	1.1	0.2	1.1	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.5	0.5	-0.2	0.7
Medication: Amlodipine	1.4	2.0	5.4	0.4	-0.5	2.3
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.5	0.1	0.7	-0.7
Birth weight	3.4	7.4	11.9	-3.5	-0.7	-3.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.5	-0.2	-0.5	0.7
High blood pressure (siblings)	0.5	0.7	1.9	0.3	-0.5	1.4
Forced vital capacity (FVC), Best measure	7.2	26.4	50.4	-7.1	-1.1	-5.2
Body fat percentage	3.1	12.4	22.9	-4.8	2.4	-2.9
Leg fat percentage (right)	1.9	6.9	10.9	-2.8	3.3	-1.4
Arm fat-free mass (right)	2.0	10.5	24.5	-5.0	0.4	-2.6
Exposure to tobacco smoke outside home	0.8	1.0	1.8	0.8	0.7	1.3
Comparative body size at age 10	1.5	4.1	8.4	1.8	-0.8	2.9
Number of full brothers	1.2	1.5	2.4	1.0	1.6	1.0
Worry too long after embarrassment	0.6	1.1	2.3	-0.9	1.5	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.7	-0.5	0.1	-0.8
Wheeze or whistling in the chest in last year	0.3	0.5	0.9	-0.5	0.9	-0.6
Number of children fathered	0.4	0.5	1.0	-0.5	-1.0	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	1.7	1.1	-1.3	1.2
Age at first live birth	0.6	1.0	1.7	1.3	0.1	1.1
Pulse wave peak to peak time	1.1	1.3	2.3	-1.5	-1.2	0.2
Health satisfaction	0.0	0.0	0.1	0.1	0.2	0.2
Shortness of breath walking on level ground	1.3	1.6	4.0	0.0	2.0	0.8
Qualifications: College or University degree	1.0	3.1	4.5	-2.1	0.9	-2.1
Eye problems/disorders: None of the above	1.5	1.8	3.8	-0.7	-1.0	-2.0
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	0.5	-0.2	0.6
Emphysema/chronic bronchitis	0.8	0.9	1.3	0.7	-1.1	0.9
Medication for pain relief, constipation, heartburn	0.8	1.4	4.0	2.0	-0.0	0.3
Neck or shoulder pain in last month	0.2	0.3	0.8	0.1	0.4	-0.9
Medication: Blood pressure	0.5	0.9	2.0	-0.7	0.2	1.4
Angina (self-reported)	1.5	2.0	3.3	1.3	-0.9	1.8
Migraine (self-reported)	0.8	1.0	2.4	-1.6	0.6	0.5
Medication: Ibuprofen	0.7	0.8	1.7	-1.3	0.0	-0.8
Medication: Allopurinol	0.1	0.1	0.4	-0.6	-0.2	-0.3
Medication: Omeprazole	0.7	0.8	1.6	-1.3	0.4	-0.8
Medication: Seretide 50 evohaler	0.2	0.3	0.6	-0.8	-0.4	0.3
Mean time to correctly identify matches	1.2	2.3	4.8	0.5	-2.2	1.3
Heart disease (mother)	2.6	3.2	6.2	1.1	-2.5	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.8	0.5	1.7	0.5
Whole body fat mass	4.3	17.9	34.0	-5.8	2.2	-3.9
Leg fat mass (right)	3.5	13.7	23.6	-4.9	3.0	-2.9
Arm predicted mass (right)	2.0	10.0	22.8	-4.8	0.2	-2.7
Pulse rate, automated reading	0.7	2.1	6.2	-0.5	-0.1	-2.5
Alcohol intake frequency.	0.1	0.2	0.3	0.1	0.5	0.6
Comparative height size at age 10	4.6	25.3	51.0	-7.1	1.7	-4.7
Number of full sisters	0.5	0.6	1.2	-0.2	-1.1	-0.6
Suffer from ‘nerves’	0.8	1.2	3.0	-1.7	0.1	-0.8
Overall health rating	0.7	1.6	4.6	-2.1	-0.3	0.3
Chest pain or discomfort	1.8	2.5	6.0	1.1	0.6	2.5
Had major operations	0.3	0.3	0.5	-0.2	-0.7	-0.7
Age at last live birth	0.9	1.3	3.2	1.8	-0.1	0.8
Family relationship satisfaction	0.8	1.0	2.7	1.6	-0.3	0.4
Leg pain on walking	1.4	1.8	4.1	1.0	0.5	2.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.5	-0.1	0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.0	-0.6	-1.0	-0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.1	-0.3	-1.1	0.1
Medication: Aspirin	0.4	0.5	1.3	-0.1	0.2	1.2
Supplements: Vitamin C	1.8	2.1	3.3	1.8	0.6	1.7
Knee pain experienced in last month	0.0	0.0	0.1	0.3	-0.0	-0.1
Hypertension (Self-reported)	0.6	1.6	2.2	-1.5	1.3	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.2	-0.6	-1.1	-0.3
Illnesses of father: Heart disease	4.7	6.5	10.9	2.7	-1.1	3.3
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-0.2	-1.0	0.2
Smoking status: Previous	0.4	0.5	1.5	1.2	0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted	2.9	6.0	9.7	-3.1	-0.6	-2.8
Whole body fat-free mass	3.2	18.6	36.7	-6.1	0.7	-4.3
Leg fat-free mass (right)	4.1	22.0	42.9	-6.5	0.1	-4.8
Arm fat percentage (left)	2.6	10.3	19.4	-4.4	1.8	-2.9
Average weekly red wine intake	1.0	1.4	2.4	-0.2	1.5	-1.4
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.7	0.5	-1.9	-0.2
Mood swings	1.0	1.7	2.6	-1.4	0.8	-1.6
Loneliness, isolation	0.6	0.8	1.4	1.2	-0.2	1.0
Long-standing illness, disability or infirmity	0.2	0.2	0.7	-0.8	0.2	0.0
Ever had bowel cancer screening	0.3	0.4	1.0	0.4	-0.2	1.0
Diabetes diagnosed by doctor	0.6	0.9	2.0	-0.8	1.4	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.7	-1.3	1.6	-0.4
Friendships satisfaction	0.9	1.1	1.7	1.2	-1.3	0.2
Qualifications: nursing, teaching	1.9	3.0	5.9	-1.5	0.9	-2.4
Commuting to job workplace: Walk	1.3	1.4	2.2	1.1	1.0	1.5
Eye problems/disorders: Cataract	1.0	1.2	2.9	0.7	1.7	0.3
Mouth/teeth dental problems: Mouth ulcers	2.0	3.1	7.8	2.8	-0.3	1.2
Medication for cholesterol	0.5	0.8	1.6	0.7	-1.3	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.5	-1.6	-0.8	-0.2
Back pain experienced in last month	1.1	1.5	2.8	-1.7	0.5	-1.2
Mineral and other dietary supplements	0.9	1.2	2.8	0.5	-0.8	1.7
Breast cancer (self-reported)	0.9	1.1	2.9	-0.4	-1.7	-0.6
Asthma (self-reported)	0.1	0.2	0.4	-0.3	-0.2	-0.7
Osteoporosis (self-reported)	0.5	0.6	0.6	0.8	0.8	0.7
Osteoarthritis (self-reported)	1.0	1.3	2.6	-1.6	1.0	-0.6
Medication: Aspirin	0.4	0.5	1.4	-0.0	-0.2	1.2
Medication: Gliclazide	0.5	0.6	1.0	-1.0	0.8	-0.1
Illnesses of father: None of the above (group 1)	2.0	2.4	3.3	-1.8	1.6	-1.2
Smoking status: Current	0.1	0.2	0.6	-0.2	-0.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.3	10.0	-3.2	-2.3	-1.9
Whole body water mass	3.1	17.8	35.4	-6.0	0.6	-4.2
Leg predicted mass (right)	4.2	22.3	43.4	-6.6	0.1	-4.8
Arm fat mass (left)	3.1	12.8	25.5	-5.0	1.8	-3.1
Number of self-reported non-cancer illnesses	3.8	6.5	12.7	-3.6	0.2	-2.6
Average weekly champagne plus white wine intake	1.9	2.6	3.8	1.1	-1.6	2.0
Miserableness	1.3	2.3	6.7	-0.3	2.6	0.5
Guilty feelings	1.2	1.8	2.7	1.5	0.7	1.6
Wears glasses or contact lenses	2.7	3.1	6.3	1.1	2.5	-1.3
Ever taken oral contraceptive pill	2.5	2.8	3.9	1.6	2.0	1.4
Hearing aid user	0.7	0.8	1.8	-0.5	0.4	-1.3
Mother’s age at death	0.8	1.0	2.0	-0.6	-1.4	0.8
Financial situation satisfaction	0.3	0.4	1.1	1.0	0.4	-0.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.8	-0.9	0.5	-1.3
Commuting to job workplace: Public transport	0.8	1.0	2.9	-1.7	0.2	0.2
Eye problems/disorders: Glaucoma	1.6	1.9	4.5	0.8	0.7	2.1
Medication: Blood pressure	0.3	0.6	1.1	-0.2	1.0	0.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.7	-0.8	0.7	-0.6
Supplements: Fish oil (including cod liver oil)	1.3	1.7	2.0	-1.4	1.2	-1.3
High cholesterol (Self-reported)	0.2	0.3	0.8	-0.9	-0.1	0.4
Medication: Bendroflumethiazide	0.5	0.7	1.6	-0.0	1.3	0.7
Medication: Paracetamol	1.0	1.5	4.0	-2.0	0.7	-0.1
Medication: Lisinopril	0.3	0.4	1.2	-0.2	1.1	-0.1
Medication: Atorvastatin	1.5	1.8	2.5	-1.5	0.9	-1.6
Illnesses of father: High blood pressure	0.4	0.4	0.7	-0.6	-0.8	0.5
Alcohol drinker status: Never	0.4	0.4	0.7	0.7	0.4	0.8
Ever smoked	1.0	1.7	3.7	0.8	1.9	0.9
Basal metabolic rate	3.7	20.5	41.5	-6.4	1.1	-4.3
Leg fat percentage (left)	1.4	5.0	7.3	-2.4	2.7	-1.5
Arm fat-free mass (left)	2.1	10.4	24.1	-4.9	0.7	-2.6
Number of operations (self-reported)	2.0	2.9	6.7	-2.6	-0.1	-1.4
Average weekly beer plus cider intake	0.9	1.3	1.4	-1.1	1.2	-1.1
Irritability	2.8	4.7	9.9	-3.1	0.3	-2.0
Risk taking	0.8	1.1	2.1	1.5	-1.1	-0.2
Ever had prostate specific antigen (PSA) test	2.7	3.1	5.5	-2.3	-0.2	-2.0
Fractured/broken bones in last 5 years	2.8	3.7	9.4	0.7	3.1	1.1
Age started oral contraceptive pill	0.7	0.8	1.5	1.2	-0.8	-0.6
Diastolic blood pressure, automated reading	0.8	2.5	5.7	-0.8	2.4	-1.0
Ever depressed for a whole week	0.8	0.9	2.3	0.5	-1.5	0.5
Unable to work because of sickness or disability	0.4	0.6	0.7	-0.9	-0.8	-0.6
Commuting to job workplace: Cycle	2.8	3.4	5.9	1.9	0.9	2.4
Myopia	0.8	1.2	2.7	-0.2	-0.9	-1.6
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.6	0.6	-1.2	-0.9
Cholesterol lowering medication	0.0	0.0	0.0	-0.0	0.0	0.2
Medication: Omeprazole (e.g. Zanprol)	2.8	3.4	6.4	-2.5	0.2	-1.9
Pain experienced in last month	0.6	0.9	2.6	1.6	-0.2	0.4
Supplements: Calcium	0.1	0.1	0.2	0.4	0.1	-0.3
Basal cell carcinoma (self-reported)	1.2	1.4	3.5	-1.9	-0.6	0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.1	-0.7	1.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	-1.1	0.2	-0.4
Heart disease (siblings)	0.2	0.2	0.3	0.6	0.3	0.5
Alcohol drinker status: Previous	0.2	0.2	0.3	-0.5	0.0	-0.6
Pack years of smoking	0.2	0.3	0.7	-0.8	-0.4	-0.2
Impedance of whole body	0.2	1.2	2.2	-1.1	0.5	-1.5
Leg fat mass (left)	3.2	12.4	21.8	-4.7	2.6	-2.9
Arm predicted mass (left)	1.8	9.3	21.7	-4.7	0.6	-2.4