Hub : Genes

RP11-793H13.11

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Putamen basal ganglia 0.2930 0.1070 2.7e-03 0.052 NA 0.022 NA 0.049 0.0230 NA 1.0e-01 NA 2.6e-02
2 GTEx Heart Left Ventricle 0.1164 0.0454 7.0e-04 0.002 NA 0.047 NA 0.016 0.2400 NA 1.6e-03 NA 4.7e-02
3 GTEx Liver 0.2160 0.0860 1.8e-03 0.097 NA 0.019 NA 0.026 0.0012 NA 9.8e-02 NA 6.4e-02
4 GTEx Muscle Skeletal 0.0674 0.0239 3.6e-05 0.035 NA 0.053 NA 0.061 0.0002 NA 5.5e-06 NA 1.2e-06
5 GTEx Skin Sun Exposed Lower leg 0.0520 0.0230 1.7e-03 0.029 NA 0.008 NA 0.022 0.0018 NA 7.1e-02 NA 6.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.2 0.3 0.7 0.0 0.4 0.9 0.4 0.8
Bipolar Disorder or Schizophrenia 0.5 1.2 3.6 0.9 0.1 1.9 0.7 -1.0
Depressed Affect (Nagel 2018) 0.8 1.7 2.8 -1.2 -1.7 -1.5 -1.4 -0.7
Depression (Nagel 2018) 0.3 0.5 1.3 -0.7 -1.1 -0.4 -0.3 -0.5
Intelligence (Savage-Jansen 2018) 0.8 2.5 8.6 -1.1 -0.9 -2.9 -1.0 0.8
Neuroticism (Nagel 2018) 0.1 0.1 0.6 0.2 -0.8 -0.2 0.0 0.1
Schizophrenia (2018) 0.7 1.4 3.1 1.1 -0.1 1.8 0.6 -1.5
Schizophrenia vs Biploar Disorder 0.2 0.3 1.4 -0.1 -0.1 0.3 -0.1 -1.2
Worry (Nagel 2018) 0.2 0.5 1.2 1.1 0.6 -0.1 0.9 0.1
Alzheimer’s Disease (in mother) 0.4 0.5 1.5 -1.2 -0.8 -0.5 -0.3 0.2
Alzheimer’s Disease (in father) 1.2 1.3 2.7 -1.3 -0.4 -1.5 -1.6 -0.2
Alzheimer’s Disease (including proxy) 1.9 2.8 4.4 -2.1 -1.6 -1.8 -1.9 -0.4
Crohns Disease (2017) 2.4 5.3 8.6 -1.8 -2.5 -2.9 -2.2 -1.7
Irritable Bowel Disease (IBD) 1.8 4.4 9.1 -1.9 -1.8 -3.0 -2.2 -1.1
Ulcerative Colitis (UC) 0.5 0.9 3.0 -0.6 -0.3 -1.7 -0.9 0.1
Major Depression (MDD) 6.6 8.0 13.1 -3.2 -2.6 -2.0 -3.6 -2.4
Reaction Time 0.6 1.2 2.2 -1.3 -1.5 -0.2 -1.3 -0.8
Verbal and Numeric Reasoning (VNR) 0.9 2.2 5.8 -1.4 -1.1 -2.4 -1.3 0.3
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 2.5 3.3 4.5 -1.6 -1.6 -2.1 -2.1 -1.6
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.4 0.6 1.9 -0.0 1.4 0.0 0.5 1.0
Bipolar Disorder (2011) 0.5 0.5 1.6 0.5 -0.6 1.3 0.5 0.0
Body Mass Index (BMI) (2010) 0.7 1.0 1.8 -1.2 -1.1 -1.3 -0.3 0.2
Coronary Artery Disease (CAD) 1.0 1.1 3.6 -0.2 0.8 0.8 0.9 1.9
Crohns Disease (2012) 2.4 3.9 5.9 -1.6 -2.4 -2.2 -2.1 -1.4
Mean Putamen Volume 0.5 0.6 1.6 0.2 0.2 1.3 0.7 0.8
Fasting Glucose 0.5 0.5 1.7 0.0 1.3 -1.0 0.1 0.0
HbA1C 0.8 0.9 3.4 -1.9 -0.3 0.0 -0.9 -0.1
HDL Cholesterol 1.9 3.1 4.5 2.1 2.1 0.3 1.9 1.7
LDL Cholesterol 2.2 3.4 9.0 -3.0 -1.1 -2.0 -1.5 -0.9
Lupus 1.0 1.6 3.0 -1.7 -1.3 -0.8 -1.4 -0.7
Neuroticism (2016) 0.6 0.8 1.3 0.4 0.8 1.1 1.0 1.0
Primary Biliary Cirrhosis 0.3 0.4 1.9 0.1 -0.2 -0.1 -0.2 -1.4
Rheumatoid Arthritis 0.5 0.6 2.6 -0.3 -0.4 0.0 0.6 -1.6
Schizophrenia (2014) 0.8 1.7 3.8 1.2 -0.2 1.8 0.4 -2.0
Triglycerides 1.1 1.9 3.2 -1.4 -1.8 -0.5 -0.9 -1.8
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.4 -0.2 0.5 1.5 0.8 1.1
Ulcerative Colitis 1.1 1.7 2.9 -1.5 -0.5 -1.6 -1.7 -0.2
Blood Eosinophil Count 0.0 0.2 0.6 0.2 0.7 0.3 0.5 0.2
Blood Platelet Count 0.8 9.1 14.5 -3.8 -3.6 -0.2 -3.0 -3.0
Blood Red Count 7.1 69.0 97.9 -9.9 -8.0 -6.2 -9.2 -7.8
Blood White Count 0.4 3.1 6.4 -1.2 -2.0 -1.0 -1.5 -2.5
Heel T-Score 2.8 22.3 48.3 1.6 5.8 4.0 3.3 7.0
BMI 0.6 3.2 6.4 -2.5 -1.6 -2.4 -1.2 -0.1
Height 0.5 9.8 31.7 -1.8 5.6 -1.6 0.1 3.3
Waist Hip Ratio (WHR) 1.2 5.6 16.8 4.1 -0.6 2.9 1.5 0.4
Systolic Blood Pressure 0.7 3.3 7.2 2.7 -0.5 2.6 1.4 0.2
Smoking Status 0.3 0.7 1.5 0.9 1.2 0.1 0.9 0.5
Allergy or Eczema 0.4 1.0 2.9 -0.9 0.0 -0.9 -0.5 -1.7
Cardiovascular Disease 0.3 1.0 4.3 0.3 -2.1 -0.0 -0.3 -0.7
Hypothyroidism (self reported) 0.5 1.3 2.6 1.5 -1.6 0.1 -0.5 -1.1
Respiratory disease 0.3 0.7 1.3 0.6 0.3 1.1 1.0 0.8
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.2 1.1 -0.2 0.9 0.5 0.9
Lung FEV1/FVC ratio 0.4 2.3 3.8 -1.8 -1.9 -1.3 -1.6 -0.7
Lung FVC 1.3 6.4 13.4 1.7 3.7 1.1 3.3 2.0
Neuroticism 0.1 0.1 0.2 0.4 0.2 0.4 0.4 -0.5
Chronotype (morning person) 0.1 0.3 0.5 -0.3 -0.7 -0.6 -0.5 -0.5
Hair Pigment 0.0 0.8 2.8 0.0 0.3 0.6 -0.9 -1.7
Tanning 0.1 1.2 2.2 1.5 0.6 0.6 1.1 1.3
Hand grip strength (left) 1.0 2.8 6.7 2.6 0.3 1.8 1.9 0.5
Number of treatments/medications taken 1.1 2.0 3.2 -0.6 -1.6 -1.2 -1.8 -1.5
Average weekly spirits intake 1.2 1.5 2.5 1.0 1.6 0.8 0.9 1.5
Sensitivity / hurt feelings 0.5 0.8 1.9 1.0 0.1 1.4 1.0 -0.1
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.7 0.2 -0.8 -0.2 0.5 -0.0
Hearing difficulty/problems: Yes 0.5 0.8 1.9 -1.4 -0.5 -0.9 -0.9 -0.2
Relative age of first facial hair 1.7 3.5 6.9 1.3 1.5 2.6 2.2 1.5
Other serious medical condition/disability diagnosed by doctor 0.7 0.8 1.6 -0.6 -0.3 -0.8 -1.3 -1.2
Ever used hormone-replacement therapy (HRT) 1.3 1.6 2.4 -1.1 -0.7 -1.3 -1.6 -1.5
Ever had hysterectomy (womb removed) 0.2 0.2 0.5 -0.1 0.7 0.5 0.5 0.4
Systolic blood pressure, automated reading 0.4 1.0 2.5 1.6 -0.2 1.4 0.6 -0.4
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.6 0.8 -0.4 0.0 0.3 0.4
Angina 0.2 0.3 0.7 0.9 0.2 0.5 0.3 0.7
Medication for hormone replacement therapy 0.0 0.0 0.1 0.1 0.2 -0.1 -0.3 -0.0
Vitamin and mineral supplements 0.5 0.7 1.6 0.4 0.8 0.8 1.3 0.8
Supplements: Zinc 0.9 0.9 2.9 -0.6 -0.5 0.7 -0.8 -1.7
Medication: Co-codamol 0.9 1.1 2.4 1.2 1.1 1.5 0.3 0.3
Medication: Metformin 0.7 0.9 2.6 -0.7 -0.4 -1.2 -1.6 0.1
Diabetes (father) 0.2 0.3 0.9 -0.3 0.9 -0.1 -0.5 0.5
Diabetes (mother) 3.4 4.4 9.2 -2.1 -1.7 -1.5 -1.8 -3.0
Severe depression (siblings) 0.5 0.6 0.8 0.4 -0.6 -0.9 -0.9 -0.9
Pack years adult smoking proportion 0.5 0.8 1.8 -0.1 -0.2 1.3 0.8 1.3
Impedance of leg (right) 1.9 9.4 22.6 4.8 2.3 3.7 2.3 0.5
Leg fat-free mass (left) 1.5 7.7 17.6 -3.9 -0.7 -4.2 -2.3 0.5
Trunk fat percentage 0.3 1.2 4.1 -2.0 -0.4 -1.1 -0.3 0.7
Hand grip strength (right) 0.8 2.2 6.0 2.5 0.5 1.6 1.5 0.4
Townsend deprivation index at recruitment 0.2 0.2 0.4 -0.6 0.2 0.7 0.5 0.1
Current tobacco smoking 0.6 1.0 2.8 0.9 0.5 0.7 0.8 1.7
Average weekly fortified wine intake 0.2 0.2 0.4 -0.7 -0.6 0.0 -0.4 -0.3
Maternal smoking around birth 1.3 1.9 4.2 1.3 0.1 2.0 1.9 -0.4
Fed-up feelings 0.6 1.0 1.6 -1.3 -1.1 -1.1 -0.9 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 -0.5 -0.5 0.5 0.2 -0.0
Relative age voice broke 0.7 1.0 2.9 0.2 0.6 1.7 1.3 0.2
Taking other prescription medications 3.9 6.1 9.1 -2.4 -2.0 -2.4 -3.0 -2.5
Age when periods started (menarche) 0.4 0.9 1.2 1.1 1.1 1.0 0.9 0.7
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 -0.4 0.1 0.3 0.2 0.4
Heel bone mineral density (BMD) T-score, automated (left) 3.3 7.5 16.2 1.8 3.3 2.2 1.7 4.0
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 3.0 1.7 -0.6 1.7 0.9 1.0
Qualifications: CSEs or equivalent 0.2 0.2 0.9 -0.1 -1.0 -0.3 -0.1 -0.4
Serious illness, injury or assault to yourself 0.5 0.7 1.6 0.2 1.3 0.9 0.9 0.1
High blood pressure 0.1 0.3 0.7 0.8 -0.8 0.0 0.1 -0.2
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.8 -0.1 0.9 -0.1 0.4 -0.4
Multivitamins +/- minerals 2.0 2.5 3.8 -1.0 -1.9 -0.9 -2.0 -1.8
Stomach or abdominal pain in last month 0.8 1.0 2.4 1.3 -0.5 1.6 1.0 -0.2
Supplements: Glucosamine 0.2 0.3 0.7 -0.2 -0.6 -0.8 -0.6 0.1
Diverticular disease/diverticulitis (self-reported) 2.5 3.0 6.2 -0.6 -1.7 -1.6 -1.8 -2.5
Medication: Atenolol 0.3 0.4 1.2 0.5 -0.4 -0.6 0.2 1.1
Medication: Levothyroxine sodium 0.3 0.5 0.8 0.9 -0.9 0.5 -0.4 -0.6
Sitting height 0.5 3.7 7.3 -2.7 2.1 -1.5 -1.1 1.9
Chronic bronchitis/emphysema (father) 0.1 0.1 0.4 0.6 -0.3 0.2 0.1 -0.2
High blood pressure (mother) 4.1 5.7 13.0 -0.4 -3.5 -1.3 -1.2 -3.6
Body mass index (BMI) 0.6 2.5 5.0 -2.2 -1.7 -1.9 -1.0 0.4
Impedance of leg (left) 2.3 11.1 21.7 4.7 2.3 4.5 2.8 1.0
Leg predicted mass (left) 1.5 7.7 17.4 -3.9 -0.7 -4.2 -2.3 0.5
Trunk fat mass 0.5 2.2 5.6 -2.4 -0.4 -2.0 -0.8 0.8
Waist circumference 0.1 0.5 1.5 -0.7 -0.3 -0.6 -0.1 1.2
Number of incorrect matches in round 3.2 5.3 7.8 2.3 2.3 2.8 2.4 1.4
Past tobacco smoking 0.1 0.2 0.5 -0.2 -0.3 0.7 0.1 0.4
Alcohol usually taken with meals 0.7 1.2 2.3 0.3 1.0 1.5 1.2 1.1
Nervous feelings 1.2 2.2 3.6 1.9 1.4 1.1 1.8 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 3.4 -0.6 -1.8 0.0 -0.1 -0.7
Hearing difficulty/problems with background noise 1.1 1.7 2.2 -1.2 -1.5 -1.4 -1.5 -0.9
Hair/balding pattern: Pattern 2 0.2 0.3 0.4 -0.5 -0.6 -0.0 -0.6 -0.6
Had menopause 1.8 2.2 2.8 -1.6 -1.2 -1.7 -1.5 -1.5
Had other major operations 1.5 1.9 3.8 -0.7 -2.0 -1.1 -1.0 -1.7
Forced vital capacity (FVC) 0.6 2.4 4.4 1.1 2.1 -0.1 1.9 1.5
Heel bone mineral density (BMD) T-score, automated (right) 3.4 7.8 12.5 1.4 3.4 3.0 1.9 3.5
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.4 -0.2 -0.6 0.2 0.0 0.1
Qualifications: None of the above 0.9 1.9 3.9 0.3 1.9 1.1 0.9 2.0
Financial difficulties in last 2 years 0.3 0.4 0.8 0.4 -0.9 -0.1 0.6 -0.7
Mouth/teeth dental problems 0.0 0.1 0.2 -0.1 0.5 0.2 -0.0 0.1
Heart attack 3.0 3.8 7.4 -2.7 -1.2 -1.8 -2.4 -1.0
Allergy 0.4 1.0 2.4 -0.1 -1.6 -0.7 -1.2 -0.8
Pain all over the body in last month 0.5 0.5 1.8 -1.4 0.1 0.4 -0.8 -0.0
Diabetes (self-reported) 0.7 1.0 1.7 1.3 0.7 1.3 0.6 1.0
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.2 0.2 0.0 0.3 0.4 0.2
Medication: Ramipril 0.5 0.7 1.9 -0.2 -1.4 0.1 -0.8 -1.0
Medication: Simvastatin 0.6 0.8 2.5 -0.4 -1.6 -0.1 -0.6 -1.1
Fluid intelligence score 0.7 1.5 4.8 -0.8 -0.5 -2.2 -1.2 -0.3
Illnesses of siblings 0.3 0.5 1.1 -1.0 -0.5 -0.8 -0.6 0.1
Neuroticism score 0.0 0.0 0.1 0.2 0.1 -0.4 0.0 -0.1
Weight 0.8 3.8 7.9 -2.7 -0.2 -2.8 -1.5 1.1
Impedance of arm (right) 0.1 0.6 1.0 -0.6 0.8 1.0 0.8 -0.5
Arm fat percentage (right) 0.7 2.8 7.7 -2.8 -1.5 -1.7 -1.0 -0.3
Trunk fat-free mass 0.7 4.0 10.6 -2.0 0.4 -3.3 -2.0 0.9
Hip circumference 0.7 3.1 8.5 -2.9 -0.4 -2.2 -1.1 0.9
Time employed in main current job 0.4 0.5 1.2 -0.8 1.1 -0.6 -0.5 -0.1
Alcohol intake versus 10 years previously 1.9 2.9 4.0 -1.4 -2.0 -1.2 -2.0 -1.8
Father’s age at death 2.7 3.7 6.3 -1.6 -0.9 -2.0 -2.5 -2.2
Worrier / anxious feelings 0.8 1.5 2.7 -0.7 -1.1 -1.6 -1.1 -1.3
Frequency of tiredness / lethargy in last 2 weeks 2.6 4.2 8.7 -2.9 -2.4 -1.4 -1.9 -1.0
Falls in the last year 1.9 2.6 4.1 2.0 1.3 1.9 1.7 0.7
Hair/balding pattern: Pattern 3 0.2 0.3 0.8 0.3 0.3 -0.9 -0.1 0.7
Number of live births 0.3 0.4 0.9 1.0 -0.4 0.9 0.3 -0.3
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 1.8 0.8 1.3 -0.4 1.2 1.0
Pulse rate 2.3 3.9 5.5 -1.6 -2.3 -2.0 -1.7 -2.1
Happiness 0.2 0.2 0.4 0.1 0.4 0.7 0.4 0.6
Noisy workplace 0.5 0.6 1.8 -1.3 0.8 -0.2 -0.2 -0.7
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.4 0.5 0.9 0.3 1.2 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.8 0.2 -0.6 0.1 -0.3 -1.3
Mouth/teeth dental problems: Dentures 0.9 1.5 3.2 -0.5 -1.7 -0.3 -1.1 -1.8
Asthma 0.5 1.0 1.9 -0.1 0.7 1.1 1.1 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.8 -0.0 0.4 0.9 0.1 0.7
Medication: Cholesterol lowering 0.2 0.3 0.7 -0.5 -0.5 -0.3 -0.9 -0.4
Depression (self-reported) 0.4 0.5 1.1 -0.3 -1.0 -0.5 -1.0 -0.5
Medication: Lansoprazole 1.2 1.3 3.5 -0.8 -1.4 -0.8 -0.1 -1.9
Prospective memory result 0.7 0.8 1.9 -1.1 -0.7 -0.7 -1.4 -0.4
Lung cancer (father) 1.6 1.8 3.0 0.6 -1.7 1.7 1.0 1.4
Illnesses of mother 2.7 3.3 5.2 0.9 2.2 1.7 1.6 2.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 0.8 0.5 0.9 -0.8 0.8 0.5
Pulse wave Arterial Stiffness index 1.6 1.8 7.1 0.5 -1.0 -0.7 -0.4 -2.7
Impedance of arm (left) 0.2 1.1 2.2 -0.3 1.5 1.2 1.3 0.4
Arm fat mass (right) 0.8 3.3 7.2 -2.7 -1.4 -2.3 -1.3 0.2
Trunk predicted mass 0.7 3.9 10.5 -2.0 0.4 -3.2 -2.0 0.9
Standing height 0.4 4.0 9.6 -1.2 3.1 -2.1 -1.0 1.8
Length of working week for main job 4.5 5.0 13.2 -1.0 -1.9 -3.6 -2.5 -0.9
Exposure to tobacco smoke at home 0.9 1.1 3.4 0.5 0.5 1.9 1.2 -0.0
Breastfed as a baby 2.0 2.4 4.3 -0.4 -1.2 -1.6 -1.9 -2.1
Tense / ‘highly strung’ 0.6 0.9 2.7 1.6 0.3 0.9 1.0 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.7 0.0 -0.6 0.8 0.0 0.0
Hair/balding pattern: Pattern 4 2.7 6.6 11.0 -2.7 -2.0 -3.3 -2.8 -1.8
Birth weight of first child 0.4 0.7 2.1 -0.1 0.7 -0.8 0.2 1.5
Peak expiratory flow (PEF) 0.0 0.1 0.2 -0.1 0.1 -0.5 0.2 -0.2
Pulse wave reflection index 0.3 0.4 0.9 0.7 0.6 -0.4 0.3 -1.0
Ever highly irritable/argumentative for 2 days 1.0 1.2 4.9 -0.0 -2.2 -0.3 -0.1 -1.1
Loud music exposure frequency 0.4 0.4 0.9 0.0 -1.0 0.4 -0.1 1.0
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.4 -0.9 -0.9 -1.0 -0.6 -1.2
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 3.8 -0.1 0.4 -0.8 0.7 1.9
Blood clot in the leg (DVT) 0.1 0.2 0.4 0.2 0.6 -0.4 0.2 -0.6
Medication: Paracetamol 1.1 1.8 4.7 -2.2 -1.6 -0.4 -1.2 -0.7
Headache pain in last month 1.3 2.3 5.3 -1.4 -2.3 0.3 -1.2 -1.6
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.9 1.3 1.0 0.7 1.7 0.7
Glaucoma (self-reported) 0.6 0.7 2.2 -0.5 0.9 -0.1 -0.1 1.5
Gout (self-reported) 1.0 1.4 3.2 1.7 0.3 -0.5 0.7 1.8
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.0 1.4 -0.8 0.1 -0.2 -0.2
Medication: Amlodipine 0.2 0.3 0.6 -0.2 -0.7 -0.3 -0.8 -0.5
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.8 0.3 0.5 0.7 0.8 0.9
Birth weight 0.8 1.7 4.3 -0.7 -1.7 -2.1 -1.0 0.3
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.9 1.2 0.1 0.7 0.4 1.4
High blood pressure (siblings) 0.2 0.3 0.6 0.7 -0.1 0.3 0.1 -0.8
Forced vital capacity (FVC), Best measure 0.5 1.7 3.6 0.6 1.9 -0.3 1.5 1.4
Body fat percentage 0.2 0.7 2.1 -1.5 -0.5 -0.7 -0.0 0.6
Leg fat percentage (right) 0.1 0.3 0.9 -0.4 -0.9 -0.5 -0.3 0.0
Arm fat-free mass (right) 0.4 2.3 6.1 -1.3 0.4 -2.5 -1.1 1.5
Exposure to tobacco smoke outside home 0.3 0.4 1.3 -0.0 0.8 -0.0 0.2 1.2
Comparative body size at age 10 0.2 0.6 1.5 -0.5 0.3 -1.1 0.1 1.2
Number of full brothers 0.2 0.2 0.5 -0.7 -0.4 0.4 -0.4 -0.3
Worry too long after embarrassment 0.7 1.2 2.5 -0.5 1.3 1.6 0.9 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 1.9 -0.8 -1.4 -0.2 -0.8 -1.1
Wheeze or whistling in the chest in last year 0.1 0.1 0.3 -0.4 -0.1 0.6 -0.0 0.2
Number of children fathered 3.0 3.4 5.0 2.0 2.2 1.6 2.0 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.2 1.2 0.6 1.5 -0.2 0.1
Age at first live birth 2.2 3.9 7.1 0.6 2.4 1.1 2.3 2.7
Pulse wave peak to peak time 1.7 2.0 7.4 -0.5 1.3 0.6 0.3 2.7
Health satisfaction 0.6 0.8 1.8 -1.4 -1.1 -0.7 -0.8 0.0
Shortness of breath walking on level ground 1.8 2.1 4.1 -2.0 -1.3 -1.2 -1.8 -0.4
Qualifications: College or University degree 0.5 1.7 2.6 1.6 -0.6 1.5 1.3 -1.3
Eye problems/disorders: None of the above 0.5 0.6 1.4 -0.7 -0.9 0.2 -0.2 -1.2
Mouth/teeth dental problems: Loose teeth 0.6 0.8 2.2 0.0 0.4 1.0 0.8 1.5
Emphysema/chronic bronchitis 0.7 0.8 1.5 1.2 0.5 1.0 1.1 0.0
Medication for pain relief, constipation, heartburn 0.4 0.7 1.9 1.4 1.0 -0.6 0.6 -0.2
Neck or shoulder pain in last month 1.7 2.4 4.3 -1.1 -2.1 -0.6 -1.6 -2.0
Medication: Blood pressure 0.7 1.2 3.3 -0.7 -1.3 -0.7 -1.8 -0.2
Angina (self-reported) 0.2 0.2 0.4 0.7 0.1 0.4 0.2 0.6
Migraine (self-reported) 0.9 1.1 2.5 -0.0 -0.8 -1.6 -1.5 -0.5
Medication: Ibuprofen 0.2 0.2 0.7 0.1 0.4 0.3 -0.0 0.8
Medication: Allopurinol 0.4 0.5 1.6 0.6 -0.1 -1.3 -0.5 0.2
Medication: Omeprazole 1.7 2.1 5.7 -2.4 -1.2 -0.6 -1.5 -0.8
Medication: Seretide 50 evohaler 0.0 0.0 0.1 -0.3 -0.0 -0.1 0.0 0.3
Mean time to correctly identify matches 0.9 1.7 3.0 -1.7 -1.5 -0.4 -1.6 -0.9
Heart disease (mother) 1.2 1.5 4.8 -0.6 -0.7 -0.4 -1.3 -2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 0.9 0.3 0.9 0.9 0.8 0.4
Whole body fat mass 0.4 1.6 4.1 -2.0 -0.5 -1.7 -0.6 0.7
Leg fat mass (right) 0.3 1.1 2.2 -1.3 -0.8 -1.5 -0.6 0.5
Arm predicted mass (right) 0.5 2.5 6.7 -1.2 0.5 -2.6 -1.2 1.6
Pulse rate, automated reading 0.8 2.5 3.3 -1.6 -1.7 -1.2 -1.5 -1.8
Alcohol intake frequency. 2.3 5.4 11.1 -3.3 -2.0 -1.9 -2.6 -1.3
Comparative height size at age 10 0.4 2.1 3.8 -0.1 1.9 -1.9 0.1 1.8
Number of full sisters 2.0 2.4 4.1 1.4 1.1 1.9 2.0 1.1
Suffer from ‘nerves’ 1.0 1.5 2.4 1.4 1.1 -0.8 1.1 1.6
Overall health rating 1.2 2.6 5.4 -2.3 -1.3 -1.7 -1.7 0.2
Chest pain or discomfort 0.2 0.3 0.8 -0.9 0.1 -0.5 -0.2 -0.4
Had major operations 2.7 3.2 5.6 -2.4 -2.0 -1.5 -1.8 -1.0
Age at last live birth 1.0 1.4 5.4 -0.1 1.1 -0.0 0.7 2.3
Family relationship satisfaction 0.1 0.1 0.4 0.1 0.4 0.4 0.1 -0.6
Leg pain on walking 0.5 0.7 1.5 -0.9 -0.2 -1.2 -0.7 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.2 0.4 -0.0 1.1 0.6 -0.2
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.5 -0.4 -0.7 0.4 -0.1 -0.7
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 1.7 0.7 1.2 -0.6 0.2 1.3
Medication: Aspirin 0.3 0.5 1.2 -0.5 -0.2 -0.7 -1.1 -0.4
Supplements: Vitamin C 0.4 0.5 1.9 0.1 -0.2 -0.4 -0.5 -1.4
Knee pain experienced in last month 0.4 0.6 2.3 -0.2 0.5 -0.0 0.5 1.5
Hypertension (Self-reported) 0.1 0.3 1.0 0.5 -1.0 -0.1 -0.3 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.2 -0.8 -0.9 -1.1 -0.7 0.1
Illnesses of father: Heart disease 0.6 0.9 1.8 -0.8 -1.1 -0.4 -0.7 -1.4
Illnesses of siblings: Diabetes 0.3 0.4 1.3 0.4 -0.2 1.1 0.7 0.3
Smoking status: Previous 0.2 0.3 0.8 -0.1 0.1 -0.7 -0.2 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.1 0.2 1.1 -0.9 -0.0 0.9
Whole body fat-free mass 0.8 4.6 12.0 -2.6 0.0 -3.5 -1.9 0.9
Leg fat-free mass (right) 1.4 7.6 17.6 -4.2 -0.9 -3.9 -2.1 0.6
Arm fat percentage (left) 0.6 2.4 7.1 -2.7 -1.4 -1.7 -0.7 0.2
Average weekly red wine intake 1.0 1.5 3.8 1.0 0.2 2.0 1.5 0.6
Handedness (chirality/laterality): Left-handed 0.8 1.0 1.8 -0.3 -1.4 -0.6 -1.0 -1.3
Mood swings 0.8 1.4 2.7 -0.9 -1.3 -1.4 -1.6 -0.4
Loneliness, isolation 0.1 0.2 0.3 -0.2 -0.6 -0.4 0.3 -0.5
Long-standing illness, disability or infirmity 0.6 0.9 2.0 -1.4 -1.0 -0.4 -1.1 -0.5
Ever had bowel cancer screening 0.7 0.8 1.8 -0.9 1.3 -0.6 0.1 1.0
Diabetes diagnosed by doctor 0.8 1.3 2.1 1.5 0.9 1.1 0.6 1.4
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.9 4.1 1.5 0.3 2.0 1.6 -0.3
Friendships satisfaction 1.1 1.4 3.2 -1.3 -1.2 -0.4 -0.5 -1.8
Qualifications: nursing, teaching 0.6 1.0 1.7 -1.2 -0.6 1.2 -0.2 -1.3
Commuting to job workplace: Walk 2.7 2.9 4.1 -1.4 -1.8 -1.5 -2.0 -1.7
Eye problems/disorders: Cataract 0.1 0.1 0.3 0.5 0.3 -0.3 0.1 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.3 0.6 0.2 -0.3 0.3 -0.1
Medication for cholesterol 0.2 0.3 0.9 0.1 1.0 0.5 0.4 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.2 4.4 2.1 0.2 1.6 1.9 0.5
Back pain experienced in last month 1.6 2.3 4.5 -2.1 -1.2 -0.9 -2.1 -0.6
Mineral and other dietary supplements 0.2 0.2 0.6 -0.2 0.8 0.1 0.7 0.1
Breast cancer (self-reported) 0.3 0.4 0.6 -0.2 -0.8 0.8 0.7 -0.4
Asthma (self-reported) 0.6 1.3 2.5 0.0 0.9 1.2 1.3 1.6
Osteoporosis (self-reported) 8.8 10.9 24.3 -2.5 -4.0 -1.3 -2.4 -4.9
Osteoarthritis (self-reported) 0.4 0.5 1.6 0.4 0.6 -0.5 -0.1 1.3
Medication: Aspirin 1.3 1.7 3.0 -1.1 -1.1 -1.4 -1.7 -1.1
Medication: Gliclazide 0.2 0.2 0.5 0.1 0.6 -0.7 -0.4 -0.2
Illnesses of father: None of the above (group 1) 2.4 2.9 4.3 1.8 1.3 1.3 1.9 2.1
Smoking status: Current 0.8 1.3 3.0 1.2 0.8 0.7 1.0 1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.2 0.2 1.1 0.4 1.0 0.3
Whole body water mass 0.8 4.5 11.9 -2.5 -0.1 -3.5 -1.9 0.8
Leg predicted mass (right) 1.5 7.8 17.8 -4.2 -0.8 -3.9 -2.2 0.6
Arm fat mass (left) 0.7 3.0 6.8 -2.6 -1.2 -2.3 -1.1 0.5
Number of self-reported non-cancer illnesses 0.3 0.5 1.6 -0.6 -0.8 -0.2 -1.3 0.2
Average weekly champagne plus white wine intake 2.0 2.7 6.2 -0.6 -2.5 -1.2 -1.4 -1.9
Miserableness 0.7 1.3 3.4 -0.5 -1.8 -1.0 -0.9 -0.8
Guilty feelings 1.3 2.0 3.2 1.6 1.5 0.3 1.3 1.8
Wears glasses or contact lenses 0.2 0.3 0.6 -0.3 -0.0 -0.8 -0.8 -0.2
Ever taken oral contraceptive pill 1.5 1.7 3.5 1.3 0.7 0.2 1.9 1.7
Hearing aid user 0.5 0.5 1.7 -0.8 -0.1 -1.3 -0.6 -0.1
Mother’s age at death 1.4 1.7 4.2 -1.1 0.1 -2.0 -1.8 0.3
Financial situation satisfaction 0.2 0.2 0.7 0.3 0.5 0.0 0.3 0.8
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.2 -0.2 0.5 -0.2 -1.1 -0.2
Commuting to job workplace: Public transport 1.3 1.5 3.3 -0.3 -1.3 -1.8 -1.4 -0.7
Eye problems/disorders: Glaucoma 0.9 1.0 2.6 -0.4 0.7 -1.2 -0.5 1.6
Medication: Blood pressure 0.2 0.4 1.2 -0.4 -1.1 0.4 -0.2 -0.6
Pain type(s) experienced in last month: Hip pain 0.9 1.2 2.4 0.9 0.7 1.1 1.1 1.5
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.4 1.2 0.1 0.6 -0.1 0.6
High cholesterol (Self-reported) 0.6 1.1 2.2 -0.7 -1.5 -0.8 -0.9 -1.2
Medication: Bendroflumethiazide 0.5 0.8 2.3 -0.9 -1.5 -0.3 -0.6 -0.6
Medication: Paracetamol 0.8 1.3 2.6 -1.6 -1.6 -0.3 -0.8 -0.7
Medication: Lisinopril 0.6 0.7 1.6 0.3 -1.0 -0.5 -1.3 -0.9
Medication: Atorvastatin 1.8 2.2 3.0 -1.4 -1.4 -1.3 -1.6 -1.7
Illnesses of father: High blood pressure 0.3 0.4 0.8 0.2 -0.9 -0.1 -0.4 -0.9
Alcohol drinker status: Never 0.4 0.5 1.0 -1.0 -1.0 -0.2 -0.4 0.5
Ever smoked 0.3 0.6 1.4 -0.4 -0.9 -1.2 -0.7 -0.2
Basal metabolic rate 0.8 4.6 11.4 -2.7 -0.2 -3.4 -1.9 0.9
Leg fat percentage (left) 0.1 0.3 0.9 -0.4 -1.0 -0.1 -0.0 0.3
Arm fat-free mass (left) 0.5 2.7 7.2 -1.6 -0.1 -2.7 -1.7 0.9
Number of operations (self-reported) 3.8 5.7 7.8 -2.4 -2.1 -2.8 -2.7 -1.6
Average weekly beer plus cider intake 1.4 2.1 8.1 2.8 0.7 0.0 1.3 0.2
Irritability 0.6 1.0 2.6 -1.1 -1.6 -0.5 -0.5 -0.7
Risk taking 0.8 1.2 2.6 0.9 -1.5 -0.4 0.6 -1.6
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.4 1.2 1.6 0.6 0.7 -0.6
Fractured/broken bones in last 5 years 3.1 4.0 10.1 -0.4 -3.2 -1.1 -1.2 -2.7
Age started oral contraceptive pill 1.1 1.3 4.0 0.4 2.0 -0.1 0.8 1.3
Diastolic blood pressure, automated reading 0.3 0.8 2.7 0.3 -1.6 0.8 -0.0 -0.9
Ever depressed for a whole week 0.4 0.5 2.2 0.4 -0.3 0.1 0.3 1.5
Unable to work because of sickness or disability 0.6 0.8 1.9 -0.6 -0.8 1.4 0.8 0.8
Commuting to job workplace: Cycle 1.0 1.2 2.0 0.7 1.3 0.9 1.4 1.0
Myopia 0.9 1.2 3.6 -1.4 -0.9 -0.2 -0.2 -1.9
Vascular/heart problems diagnosed by doctor 0.1 0.3 1.3 -0.3 1.1 0.2 0.4 0.2
Cholesterol lowering medication 1.0 1.5 2.3 -1.0 -1.5 -1.3 -1.2 -1.1
Medication: Omeprazole (e.g. Zanprol) 1.3 1.5 5.0 -2.2 -0.8 -0.5 -1.2 -0.5
Pain experienced in last month 1.9 3.1 6.7 2.6 2.1 0.8 1.7 0.9
Supplements: Calcium 3.3 3.7 10.1 -1.0 -2.0 -0.7 -1.7 -3.2
Basal cell carcinoma (self-reported) 1.4 1.6 5.1 -0.9 1.5 -0.3 0.3 2.2
Heart attack/myocardial infarction (self-reported) 4.1 5.3 9.4 -3.1 -1.6 -2.1 -2.8 -1.4
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 0.1 0.5 -0.3 0.4 -0.5
Heart disease (siblings) 0.2 0.3 1.1 -0.0 0.1 -0.2 -0.5 -1.0
Alcohol drinker status: Previous 1.1 1.2 2.9 -1.2 -0.7 -0.3 -1.1 -1.7
Pack years of smoking 0.3 0.5 1.5 -0.3 -0.3 1.2 0.4 0.7
Impedance of whole body 0.9 4.4 7.6 2.2 2.2 2.8 2.0 0.9
Leg fat mass (left) 0.3 1.1 2.2 -1.5 -0.9 -1.4 -0.6 0.6
Arm predicted mass (left) 0.5 2.7 7.1 -1.7 -0.2 -2.7 -1.7 0.8