Hub : Genes

RP11-810M2.2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Coronary 0.296 0.097 0.00550 0.018 NA 0.004 NA 0.017 8.0e-02 NA 0.230 NA 0.0850
2 GTEx Brain Nucleus accumbens basal ganglia 0.242 0.098 0.00051 0.173 NA 0.058 NA 0.099 2.2e-05 NA 0.012 NA 0.0013

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.9 1.4 2.2 0.8 -1.5
Bipolar Disorder or Schizophrenia 2.0 4.9 6.5 1.8 -2.5
Depressed Affect (Nagel 2018) 0.0 0.0 0.1 0.0 -0.3
Depression (Nagel 2018) 3.0 4.5 7.0 -2.6 1.4
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.4 1.2 -0.5
Neuroticism (Nagel 2018) 0.2 0.4 0.6 -0.8 0.5
Schizophrenia (2018) 1.8 3.8 4.2 1.8 -2.1
Schizophrenia vs Biploar Disorder 0.5 0.6 0.9 0.6 -0.9
Worry (Nagel 2018) 0.8 1.7 2.5 -1.6 1.0
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 0.4 0.2
Alzheimer’s Disease (in father) 1.2 1.3 2.3 0.6 -1.5
Alzheimer’s Disease (including proxy) 0.0 0.0 0.0 -0.2 -0.1
Crohns Disease (2017) 0.2 0.3 0.7 0.8 -0.1
Irritable Bowel Disease (IBD) 0.2 0.5 1.0 -0.0 1.0
Ulcerative Colitis (UC) 0.5 1.0 1.5 -0.7 1.2
Major Depression (MDD) 0.2 0.3 0.6 0.0 0.8
Reaction Time 6.0 11.5 15.8 4.0 -2.7
Verbal and Numeric Reasoning (VNR) 0.8 1.9 2.2 1.5 -1.3
Breast Cancer 0.5 1.3 1.3 -1.1 1.1
Ovarian Cancer 0.5 0.7 1.1 1.1 -0.5
Prostate Cancer 0.4 0.5 0.7 -0.8 0.6
Age at First Birth 0.1 0.1 0.2 -0.4 0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 0.8 -0.2 -0.9
Coronary Artery Disease (CAD) 1.5 1.7 3.4 1.9 -0.3
Crohns Disease (2012) 0.4 0.7 1.3 0.2 -1.1
Mean Putamen Volume 1.3 1.5 2.0 1.0 -1.4
Fasting Glucose 0.4 0.5 1.0 1.0 0.2
HbA1C 2.3 2.6 2.8 1.7 -1.6
HDL Cholesterol 0.6 1.0 1.3 -0.9 1.1
LDL Cholesterol 1.5 2.4 2.8 1.4 -1.7
Lupus 1.1 1.7 3.3 -1.8 -0.1
Neuroticism (2016) 1.2 1.8 2.6 1.6 -1.0
Primary Biliary Cirrhosis 0.0 0.1 0.1 0.3 -0.2
Rheumatoid Arthritis 1.3 1.7 2.6 -0.9 1.6
Schizophrenia (2014) 2.3 5.1 5.4 2.2 -2.3
Triglycerides 0.3 0.6 0.9 0.9 0.5
Type 2 Diabetes (T2D) (2012) 1.1 1.2 1.4 1.2 -1.0
Ulcerative Colitis 1.3 1.9 2.2 -1.5 1.3
Blood Eosinophil Count 0.1 0.6 0.6 0.8 -0.8
Blood Platelet Count 1.4 15.7 20.5 -3.3 4.5
Blood Red Count 0.2 2.3 3.9 2.0 0.9
Blood White Count 0.5 3.4 6.1 0.8 2.5
Heel T-Score 2.7 21.5 28.6 5.3 -3.8
BMI 2.2 12.6 15.6 4.0 -3.1
Height 1.0 19.8 39.3 6.3 -0.6
Waist Hip Ratio (WHR) 4.7 21.3 26.2 4.1 -5.1
Systolic Blood Pressure 0.8 4.2 6.4 2.5 -1.4
Smoking Status 0.1 0.2 0.2 -0.5 -0.4
Allergy or Eczema 0.1 0.2 0.2 -0.3 -0.4
Cardiovascular Disease 5.6 18.5 29.3 5.4 -2.8
Hypothyroidism (self reported) 1.1 2.5 5.1 -0.0 2.2
Respiratory disease 0.5 1.1 2.2 0.3 1.5
Type 2 Diabetes (T2D) (2018) 5.0 9.3 12.3 2.5 -3.5
Lung FEV1/FVC ratio 10.4 52.6 66.4 6.2 -8.2
Lung FVC 2.0 10.0 10.6 -3.1 3.2
Neuroticism 0.4 0.9 1.2 -0.8 1.1
Chronotype (morning person) 5.3 12.3 19.0 4.4 -2.4
Hair Pigment 0.0 0.6 0.6 -0.8 0.8
Tanning 0.0 0.6 1.1 -1.1 0.2
Hand grip strength (left) 2.2 5.7 7.1 -2.1 2.7
Number of treatments/medications taken 1.9 3.5 6.5 2.5 -0.7
Average weekly spirits intake 2.0 2.4 3.3 -1.2 1.8
Sensitivity / hurt feelings 0.0 0.0 0.1 -0.2 -0.1
Frequency of depressed mood in last 2 weeks 2.4 3.3 4.9 -2.2 1.3
Hearing difficulty/problems: Yes 0.7 1.0 2.0 1.4 -0.0
Relative age of first facial hair 1.3 2.7 3.7 -1.9 1.3
Other serious medical condition/disability diagnosed by doctor 2.3 3.0 5.9 2.4 0.2
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.5 0.7 0.5
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 0.5 -0.2
Systolic blood pressure, automated reading 0.5 1.5 2.6 1.6 -0.6
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.1 0.2 -1.0
Angina 1.0 1.3 2.5 1.6 0.3
Medication for hormone replacement therapy 0.5 0.5 0.7 -0.6 0.9
Vitamin and mineral supplements 0.3 0.4 0.6 -0.8 0.3
Supplements: Zinc 1.6 1.7 3.0 -1.7 0.7
Medication: Co-codamol 0.2 0.2 0.5 0.0 0.7
Medication: Metformin 2.6 3.7 5.5 2.4 -1.3
Diabetes (father) 2.5 3.0 3.4 1.8 -1.6
Diabetes (mother) 3.5 4.5 6.3 1.7 -2.5
Severe depression (siblings) 0.9 1.0 1.7 -1.3 0.6
Pack years adult smoking proportion 0.2 0.3 0.4 0.7 -0.4
Impedance of leg (right) 0.4 1.8 3.4 0.5 -1.8
Leg fat-free mass (left) 1.2 6.3 11.9 3.5 -0.8
Trunk fat percentage 5.2 20.7 33.1 5.7 -2.9
Hand grip strength (right) 1.4 3.8 4.6 -1.7 2.2
Townsend deprivation index at recruitment 0.5 0.8 1.0 -0.7 1.0
Current tobacco smoking 0.5 0.8 1.7 -1.3 0.0
Average weekly fortified wine intake 2.8 3.3 6.6 2.6 -0.1
Maternal smoking around birth 0.1 0.1 0.2 0.1 0.5
Fed-up feelings 0.1 0.1 0.2 -0.5 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 3.4 4.6 8.6 -2.9 0.7
Relative age voice broke 0.0 0.1 0.1 -0.3 0.3
Taking other prescription medications 0.5 0.8 0.9 1.0 0.8
Age when periods started (menarche) 0.7 1.6 2.9 -1.7 0.5
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.6 -0.1 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.4 0.6 -0.4
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.3 -0.0 -0.5
Qualifications: CSEs or equivalent 0.6 0.8 1.0 -1.0 0.7
Serious illness, injury or assault to yourself 0.5 0.6 0.8 -0.6 0.9
High blood pressure 7.5 20.8 35.0 5.9 -2.6
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.0 -0.3 -1.0
Multivitamins +/- minerals 0.1 0.2 0.2 0.4 -0.4
Stomach or abdominal pain in last month 0.1 0.1 0.3 0.5 -0.1
Supplements: Glucosamine 0.1 0.1 0.2 0.1 0.5
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.7 0.8 -0.0
Medication: Atenolol 4.3 5.3 9.5 3.1 -1.1
Medication: Levothyroxine sodium 0.9 1.5 3.0 -0.0 1.7
Sitting height 0.4 2.5 4.9 2.2 -0.3
Chronic bronchitis/emphysema (father) 0.8 1.0 1.5 -1.2 -0.7
High blood pressure (mother) 2.3 3.2 5.8 2.4 -0.8
Body mass index (BMI) 2.1 9.1 15.1 3.9 -1.8
Impedance of leg (left) 0.3 1.5 2.8 0.6 -1.7
Leg predicted mass (left) 1.2 6.1 11.7 3.4 -0.8
Trunk fat mass 5.1 22.0 35.9 6.0 -2.8
Waist circumference 4.9 18.0 27.4 5.2 -2.9
Number of incorrect matches in round 0.2 0.3 0.4 -0.3 0.6
Past tobacco smoking 0.1 0.1 0.2 -0.2 -0.4
Alcohol usually taken with meals 0.3 0.4 0.7 0.9 0.4
Nervous feelings 1.1 2.0 2.5 -1.2 1.6
Frequency of tenseness / restlessness in last 2 weeks 4.6 7.2 9.6 -3.1 2.2
Hearing difficulty/problems with background noise 0.3 0.5 0.8 0.9 0.3
Hair/balding pattern: Pattern 2 1.2 1.5 1.6 -1.3 1.2
Had menopause 0.5 0.7 1.0 1.0 -0.6
Had other major operations 0.2 0.3 0.4 0.3 -0.7
Forced vital capacity (FVC) 0.5 1.9 2.6 -1.1 1.6
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 1.5 1.2 -0.8
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.3 0.6 -0.5
Qualifications: None of the above 0.1 0.2 0.3 -0.1 0.6
Financial difficulties in last 2 years 2.5 3.3 6.3 -2.5 0.5
Mouth/teeth dental problems 0.5 0.7 1.0 -1.0 -0.7
Heart attack 1.4 1.8 2.8 1.7 -0.9
Allergy 0.0 0.0 0.0 0.0 -0.0
Pain all over the body in last month 1.0 1.1 1.8 -0.6 1.4
Diabetes (self-reported) 3.4 5.2 6.9 1.9 -2.6
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.2 1.1 -0.3
Medication: Ramipril 8.3 10.7 12.7 3.6 -3.0
Medication: Simvastatin 1.1 1.7 3.3 1.8 -0.0
Fluid intelligence score 0.4 0.8 1.2 1.1 -0.7
Illnesses of siblings 2.3 3.3 5.4 -2.3 -1.1
Neuroticism score 0.6 1.3 1.3 -1.2 1.1
Weight 3.6 17.7 29.2 5.4 -2.5
Impedance of arm (right) 0.0 0.0 0.0 -0.1 0.0
Arm fat percentage (right) 2.6 10.2 17.0 4.1 -1.9
Trunk fat-free mass 1.1 6.3 11.2 3.3 -1.2
Hip circumference 2.2 9.7 17.2 4.1 -1.5
Time employed in main current job 0.2 0.2 0.3 -0.5 -0.3
Alcohol intake versus 10 years previously 0.6 1.0 1.4 1.2 -0.7
Father’s age at death 2.1 2.8 5.2 -2.3 0.7
Worrier / anxious feelings 1.3 2.5 4.3 -2.1 0.8
Frequency of tiredness / lethargy in last 2 weeks 2.2 3.5 5.4 -1.3 2.3
Falls in the last year 0.8 1.0 2.1 0.0 1.4
Hair/balding pattern: Pattern 3 0.2 0.4 0.6 -0.4 0.7
Number of live births 2.9 4.1 5.9 1.5 -2.4
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.1 0.3 -0.3
Pulse rate 1.0 1.7 2.1 1.2 -1.4
Happiness 0.2 0.3 0.4 0.5 -0.6
Noisy workplace 2.0 2.5 4.8 0.4 -2.2
Qualifications: A levels/AS levels or equivalent 1.2 2.6 3.1 1.5 -1.8
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.7 -0.9 -0.2
Mouth/teeth dental problems: Dentures 1.3 2.2 4.3 -0.3 2.1
Asthma 0.4 0.8 1.6 -0.1 1.3
Medication: Ibuprofen (e.g. Nurofen) 3.4 4.4 7.7 -1.0 2.8
Medication: Cholesterol lowering 0.2 0.3 0.6 0.8 -0.1
Depression (self-reported) 1.1 1.3 1.9 -1.4 0.8
Medication: Lansoprazole 0.6 0.7 1.4 -0.2 1.2
Prospective memory result 0.0 0.0 0.0 0.1 -0.0
Lung cancer (father) 0.2 0.2 0.2 0.5 -0.4
Illnesses of mother 1.4 1.7 3.5 -1.9 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 0.7 0.7 -0.8
Pulse wave Arterial Stiffness index 1.6 1.9 2.9 0.9 -1.7
Impedance of arm (left) 0.0 0.2 0.2 -0.3 0.5
Arm fat mass (right) 3.8 15.5 25.4 5.0 -2.4
Trunk predicted mass 1.1 6.1 11.0 3.3 -1.1
Standing height 1.1 10.6 17.9 4.2 -1.8
Length of working week for main job 0.5 0.6 1.2 -1.1 -0.1
Exposure to tobacco smoke at home 0.4 0.4 0.5 0.7 -0.6
Breastfed as a baby 0.1 0.1 0.1 -0.3 -0.4
Tense / ‘highly strung’ 0.9 1.4 2.4 -0.7 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.9 0.1 1.4
Hair/balding pattern: Pattern 4 1.1 2.8 5.1 2.2 -0.7
Birth weight of first child 0.4 0.7 0.7 0.8 -0.9
Peak expiratory flow (PEF) 0.1 0.2 0.4 0.3 0.6
Pulse wave reflection index 0.2 0.2 0.4 -0.1 -0.7
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.5 0.7 -0.3
Loud music exposure frequency 0.0 0.0 0.1 -0.1 0.3
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.6 0.8 -0.5
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 2.0 1.4 -1.2
Blood clot in the leg (DVT) 0.6 0.8 1.2 1.1 -0.6
Medication: Paracetamol 2.9 4.8 6.6 -1.8 2.6
Headache pain in last month 0.1 0.1 0.2 0.1 -0.4
Medication for cholesterol, blood pressure or diabetes 3.3 5.5 9.6 -3.1 1.1
Glaucoma (self-reported) 0.1 0.2 0.2 0.4 -0.4
Gout (self-reported) 0.9 1.2 2.1 0.6 1.4
Hypothyroidism/myxoedema (self-reported) 1.7 3.4 6.6 -0.4 2.6
Medication: Amlodipine 5.6 7.8 8.5 2.7 -2.9
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.4 -0.6 0.2
Birth weight 3.3 7.1 8.6 2.4 -2.9
Chronic bronchitis/emphysema (mother) 1.8 2.1 4.2 0.3 2.0
High blood pressure (siblings) 2.9 4.2 7.7 2.8 -0.8
Forced vital capacity (FVC), Best measure 0.3 1.2 1.7 -0.8 1.3
Body fat percentage 4.8 19.0 29.3 5.4 -3.0
Leg fat percentage (right) 4.5 16.3 21.8 4.7 -3.3
Arm fat-free mass (right) 1.6 8.1 13.8 3.7 -1.6
Exposure to tobacco smoke outside home 0.5 0.7 0.9 1.0 0.6
Comparative body size at age 10 1.2 3.3 5.5 1.0 -2.3
Number of full brothers 2.0 2.6 4.8 2.2 -0.6
Worry too long after embarrassment 0.3 0.5 0.7 0.8 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.9 0.2 0.9
Wheeze or whistling in the chest in last year 0.9 1.6 2.2 1.5 -1.0
Number of children fathered 0.3 0.3 0.6 -0.8 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.4 -0.1 -1.2
Age at first live birth 0.3 0.6 0.7 -0.6 -0.9
Pulse wave peak to peak time 1.2 1.4 2.6 -0.5 1.6
Health satisfaction 0.0 0.1 0.1 -0.3 -0.2
Shortness of breath walking on level ground 0.1 0.1 0.2 0.4 -0.3
Qualifications: College or University degree 1.5 4.7 5.9 1.9 -2.4
Eye problems/disorders: None of the above 0.2 0.3 0.5 -0.7 -0.0
Mouth/teeth dental problems: Loose teeth 1.2 1.4 1.8 1.3 -1.0
Emphysema/chronic bronchitis 0.7 0.8 0.8 -0.9 0.9
Medication for pain relief, constipation, heartburn 1.3 2.2 4.3 -0.0 -2.1
Neck or shoulder pain in last month 0.5 0.8 1.5 -1.2 0.2
Medication: Blood pressure 6.1 10.7 19.5 4.4 -1.4
Angina (self-reported) 0.6 0.9 1.2 1.1 0.7
Migraine (self-reported) 0.1 0.2 0.3 -0.6 -0.2
Medication: Ibuprofen 2.6 3.1 5.1 -1.1 2.2
Medication: Allopurinol 0.7 0.9 1.4 1.2 0.6
Medication: Omeprazole 0.1 0.1 0.1 -0.2 0.3
Medication: Seretide 50 evohaler 2.0 2.4 4.7 -2.2 0.2
Mean time to correctly identify matches 7.7 14.8 22.7 4.8 -2.6
Heart disease (mother) 0.2 0.2 0.4 0.1 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.8 3.3 3.5 -1.8 1.9
Whole body fat mass 4.8 20.1 31.8 5.6 -2.9
Leg fat mass (right) 4.4 17.1 24.5 4.9 -3.1
Arm predicted mass (right) 1.6 8.3 13.6 3.7 -1.7
Pulse rate, automated reading 1.6 5.3 6.5 2.5 -2.0
Alcohol intake frequency. 0.3 0.7 1.1 1.1 0.5
Comparative height size at age 10 2.1 11.8 21.1 4.6 -1.6
Number of full sisters 0.7 0.8 1.1 1.1 0.7
Suffer from ‘nerves’ 0.1 0.1 0.2 -0.4 -0.1
Overall health rating 0.3 0.6 0.7 0.6 0.9
Chest pain or discomfort 0.4 0.5 0.8 0.9 0.5
Had major operations 0.3 0.3 0.5 -0.7 0.3
Age at last live birth 0.3 0.4 0.4 -0.6 -0.7
Family relationship satisfaction 0.9 1.1 1.8 1.3 -0.5
Leg pain on walking 1.6 2.0 3.6 -0.7 -1.9
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.0 -0.3 -1.0
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.0 -1.0 -0.2
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.1 1.4 -0.0
Medication: Aspirin 2.1 2.8 3.6 1.9 -1.4
Supplements: Vitamin C 2.0 2.4 3.7 1.9 -1.0
Knee pain experienced in last month 0.7 1.2 1.4 1.2 -1.0
Hypertension (Self-reported) 8.4 23.4 38.1 6.2 -2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.4 0.0 0.6
Illnesses of father: Heart disease 1.4 2.0 3.9 0.2 2.0
Illnesses of siblings: Diabetes 3.7 4.6 7.3 2.7 -1.4
Smoking status: Previous 0.1 0.1 0.1 0.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 1.3 1.1 -0.3
Whole body fat-free mass 1.2 6.7 12.1 3.5 -1.1
Leg fat-free mass (right) 0.9 4.8 9.3 3.0 -0.6
Arm fat percentage (left) 2.4 9.8 16.7 4.1 -1.7
Average weekly red wine intake 0.1 0.1 0.2 -0.4 0.0
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.1 -0.2 0.3
Mood swings 0.1 0.2 0.3 -0.5 -0.5
Loneliness, isolation 0.1 0.1 0.2 -0.4 -0.3
Long-standing illness, disability or infirmity 2.0 3.1 4.0 2.0 -1.5
Ever had bowel cancer screening 0.3 0.3 0.7 0.8 0.1
Diabetes diagnosed by doctor 4.4 7.2 7.9 2.5 -2.8
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.5 -0.3 0.7
Friendships satisfaction 0.5 0.6 0.7 0.7 -0.8
Qualifications: nursing, teaching 0.9 1.4 1.8 1.0 -1.3
Commuting to job workplace: Walk 0.4 0.4 0.6 0.4 0.8
Eye problems/disorders: Cataract 0.6 0.7 1.4 0.2 1.2
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.0 0.2 0.1
Medication for cholesterol 4.7 7.1 11.0 -3.3 1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 0.4 0.2
Back pain experienced in last month 0.8 1.2 2.2 1.5 -0.4
Mineral and other dietary supplements 1.6 2.2 2.4 -1.6 1.4
Breast cancer (self-reported) 0.7 0.8 1.5 -1.2 -0.3
Asthma (self-reported) 0.4 0.8 1.5 -0.3 1.2
Osteoporosis (self-reported) 0.4 0.5 0.9 -0.1 1.0
Osteoarthritis (self-reported) 0.3 0.4 0.7 0.8 -0.3
Medication: Aspirin 3.0 3.9 4.2 2.0 -1.9
Medication: Gliclazide 2.0 2.2 3.0 1.7 -1.2
Illnesses of father: None of the above (group 1) 0.2 0.2 0.4 0.6 -0.0
Smoking status: Current 0.1 0.2 0.4 -0.6 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.3 4.7 1.4 -2.2
Whole body water mass 1.1 6.5 11.8 3.4 -1.1
Leg predicted mass (right) 0.9 4.8 9.4 3.1 -0.5
Arm fat mass (left) 3.5 14.5 23.2 4.8 -2.4
Number of self-reported non-cancer illnesses 2.0 3.4 6.7 2.6 -0.3
Average weekly champagne plus white wine intake 1.3 1.8 3.6 1.9 -0.2
Miserableness 1.0 1.7 2.2 -1.1 1.5
Guilty feelings 0.2 0.3 0.5 -0.7 0.2
Wears glasses or contact lenses 0.1 0.1 0.2 -0.4 -0.1
Ever taken oral contraceptive pill 0.1 0.2 0.2 0.4 -0.4
Hearing aid user 0.0 0.0 0.0 0.0 0.0
Mother’s age at death 1.7 2.1 2.9 -1.7 1.1
Financial situation satisfaction 1.9 2.4 2.5 -1.5 1.6
Tinnitus: Yes, now most or all of the time 0.8 1.0 1.6 -1.3 0.6
Commuting to job workplace: Public transport 0.5 0.6 1.1 -0.2 1.1
Eye problems/disorders: Glaucoma 0.1 0.1 0.3 -0.1 -0.5
Medication: Blood pressure 6.8 12.9 18.1 4.3 -2.8
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 0.4 0.0
Supplements: Fish oil (including cod liver oil) 1.7 2.2 2.7 1.6 -1.3
High cholesterol (Self-reported) 0.0 0.1 0.1 0.3 0.1
Medication: Bendroflumethiazide 5.6 8.4 14.8 3.9 -1.4
Medication: Paracetamol 2.3 3.5 4.0 -1.7 2.0
Medication: Lisinopril 1.6 2.1 3.1 1.8 -1.0
Medication: Atorvastatin 3.2 3.9 6.2 2.5 -1.3
Illnesses of father: High blood pressure 0.7 0.9 1.3 -1.1 0.7
Alcohol drinker status: Never 2.7 3.2 5.1 -1.1 2.3
Ever smoked 0.0 0.0 0.0 0.2 0.0
Basal metabolic rate 1.7 9.2 16.1 4.0 -1.5
Leg fat percentage (left) 4.4 16.1 23.1 4.8 -3.0
Arm fat-free mass (left) 2.0 10.2 17.5 4.2 -1.7
Number of operations (self-reported) 0.7 1.1 1.9 -0.5 1.4
Average weekly beer plus cider intake 0.1 0.1 0.2 -0.4 0.1
Irritability 2.6 4.4 7.4 -1.2 2.7
Risk taking 0.5 0.7 1.1 0.5 -1.1
Ever had prostate specific antigen (PSA) test 3.0 3.5 5.6 2.4 -1.2
Fractured/broken bones in last 5 years 0.5 0.6 1.3 -1.1 -0.0
Age started oral contraceptive pill 1.7 2.2 4.3 2.1 -0.3
Diastolic blood pressure, automated reading 5.2 16.2 16.8 3.9 -4.1
Ever depressed for a whole week 1.9 2.3 4.2 2.0 -0.7
Unable to work because of sickness or disability 1.9 2.4 3.3 -1.2 1.8
Commuting to job workplace: Cycle 0.6 0.7 1.4 -1.2 0.1
Myopia 2.9 4.2 6.0 2.5 -1.6
Vascular/heart problems diagnosed by doctor 5.9 16.1 28.5 -5.3 1.9
Cholesterol lowering medication 4.9 7.2 10.6 3.2 -2.0
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 0.4 0.3
Pain experienced in last month 0.2 0.3 0.5 0.3 -0.7
Supplements: Calcium 1.0 1.1 1.4 -1.2 0.9
Basal cell carcinoma (self-reported) 0.5 0.6 0.9 0.9 -0.5
Heart attack/myocardial infarction (self-reported) 1.7 2.3 3.6 1.9 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.6 0.8 -0.4
Heart disease (siblings) 1.9 2.3 2.6 1.4 1.6
Alcohol drinker status: Previous 0.0 0.0 0.1 0.3 0.1
Pack years of smoking 0.3 0.5 0.7 0.8 -0.6
Impedance of whole body 0.1 0.3 0.6 0.2 -0.8
Leg fat mass (left) 4.5 17.4 26.3 5.1 -2.9
Arm predicted mass (left) 2.0 10.0 16.5 4.1 -1.9