Hub : Genes

RP13-514E23.2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.086 0.0400 8.1e-03 0.033 NA 0.043 NA 0.032 9.4e-04 NA 2.0e-04 NA 1.1e-03
2 GTEx Artery Aorta 0.255 0.0650 1.8e-05 0.095 NA 0.097 NA 0.105 6.7e-06 NA 5.0e-06 NA 2.2e-06
3 GTEx Artery Tibial 0.218 0.0521 2.8e-06 0.161 NA 0.175 NA 0.166 1.2e-12 NA 1.2e-13 NA 5.3e-13
4 GTEx Nerve Tibial 0.172 0.0557 6.5e-04 -0.002 NA 0.001 NA 0.003 5.0e-01 NA 2.6e-01 NA 1.9e-01
5 GTEx Ovary 0.185 0.0720 7.6e-03 0.143 NA 0.053 NA 0.067 2.3e-04 NA 2.0e-02 NA 9.9e-03
6 GTEx Skin Sun Exposed Lower leg 0.067 0.0290 6.2e-03 0.004 NA 0.001 NA 0.007 1.3e-01 NA 2.7e-01 NA 7.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.4 0.6 3.1 0.3 0.2 0.0 -1.8 -0.3 0.7
Bipolar Disorder or Schizophrenia 0.2 0.5 2.1 0.6 -0.4 -0.1 -1.4 0.4 0.7
Depressed Affect (Nagel 2018) 0.1 0.2 0.6 0.8 0.5 0.6 -0.2 -0.0 -0.0
Depression (Nagel 2018) 0.2 0.3 0.8 0.5 0.6 0.9 -0.2 -0.2 0.1
Intelligence (Savage-Jansen 2018) 1.2 3.6 7.1 -2.2 -2.7 -2.5 -1.7 -0.3 -0.3
Neuroticism (Nagel 2018) 0.4 0.9 1.8 1.1 1.2 1.3 -0.2 -0.9 0.1
Schizophrenia (2018) 0.1 0.3 0.6 0.5 -0.7 -0.1 -0.4 0.8 0.4
Schizophrenia vs Biploar Disorder 0.7 1.0 3.1 -0.6 -0.3 -0.2 1.5 1.7 0.2
Worry (Nagel 2018) 1.0 2.1 4.8 1.6 2.1 2.2 0.2 -0.6 -0.6
Alzheimer’s Disease (in mother) 0.3 0.3 0.9 -1.0 0.3 0.4 -0.0 0.5 -0.8
Alzheimer’s Disease (in father) 0.3 0.3 1.0 0.1 0.7 0.6 1.0 0.3 -0.5
Alzheimer’s Disease (including proxy) 0.4 0.6 1.3 -0.6 0.6 0.7 0.9 1.1 -0.8
Crohns Disease (2017) 1.4 3.1 6.3 -1.8 -2.4 -2.5 -1.6 0.1 -0.5
Irritable Bowel Disease (IBD) 0.9 2.1 4.9 -2.2 -1.7 -1.7 -0.4 0.7 -1.2
Ulcerative Colitis (UC) 0.5 0.9 2.6 -1.6 -0.3 -0.2 0.9 1.1 -0.9
Major Depression (MDD) 0.2 0.2 0.6 0.5 0.8 0.6 0.0 0.3 -0.0
Reaction Time 0.2 0.4 1.2 -1.1 -0.2 0.1 -0.8 -0.3 -0.6
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.9 -1.1 -1.7 -1.4 -0.7 -0.5 0.2
Breast Cancer 1.1 2.7 10.9 1.8 -0.4 -0.0 0.9 1.1 3.3
Ovarian Cancer 1.1 1.5 4.5 0.3 1.2 0.9 2.1 1.3 0.4
Prostate Cancer 0.3 0.5 1.8 1.3 0.2 0.4 0.0 -0.7 0.5
Age at First Birth 0.1 0.1 0.3 -0.5 -0.2 -0.3 -0.0 -0.4 -0.1
Bipolar Disorder (2011) 1.1 1.1 5.6 0.0 0.5 0.8 -0.4 2.4 0.3
Body Mass Index (BMI) (2010) 0.8 1.1 2.6 0.8 1.2 1.0 0.5 -1.6 0.8
Coronary Artery Disease (CAD) 1.3 1.6 4.6 -0.1 -0.0 -0.2 -2.1 -1.7 -1.4
Crohns Disease (2012) 1.2 2.0 5.5 -1.2 -1.9 -2.3 -0.9 0.7 -0.4
Mean Putamen Volume 0.6 0.7 2.0 -1.4 -0.8 -0.9 0.4 -0.3 -0.6
Fasting Glucose 0.7 0.8 2.2 -0.5 -1.3 -1.5 -0.2 -0.1 0.7
HbA1C 0.4 0.4 1.0 -0.6 -0.6 -0.6 0.1 -0.5 1.0
HDL Cholesterol 0.9 1.6 3.3 -1.8 -1.2 -1.8 -1.0 -0.6 -0.6
LDL Cholesterol 0.3 0.5 1.6 0.5 0.7 0.6 1.3 0.5 0.1
Lupus 0.9 1.4 4.5 0.9 0.5 0.7 -1.6 -2.1 -0.0
Neuroticism (2016) 0.2 0.3 1.0 0.3 0.3 0.4 1.0 -0.4 0.2
Primary Biliary Cirrhosis 0.2 0.3 0.6 -0.8 -0.2 -0.6 -0.2 0.6 -0.8
Rheumatoid Arthritis 0.4 0.5 1.8 -1.1 -0.4 -0.4 0.1 0.1 -1.4
Schizophrenia (2014) 0.2 0.4 1.2 0.1 -0.8 -0.5 -0.6 1.1 -0.5
Triglycerides 0.5 0.8 1.1 0.8 0.7 0.8 1.0 0.9 1.0
Type 2 Diabetes (T2D) (2012) 1.4 1.6 4.5 1.5 0.8 1.0 1.1 2.1 0.5
Ulcerative Colitis 0.9 1.3 3.1 -0.7 0.9 0.7 1.8 1.6 -0.4
Blood Eosinophil Count 0.3 2.3 6.7 1.6 1.6 2.6 0.9 -1.0 -0.7
Blood Platelet Count 1.5 17.3 34.7 3.5 5.9 5.9 4.4 -0.7 1.5
Blood Red Count 0.2 1.7 4.0 2.0 0.9 0.5 -1.4 -1.5 -0.8
Blood White Count 1.4 10.1 19.6 2.9 4.4 4.4 3.5 -0.9 0.6
Heel T-Score 10.8 85.5 179.6 9.0 13.3 13.4 8.1 -0.9 3.1
BMI 0.1 0.7 2.4 -0.8 -0.5 -0.8 -0.6 0.2 -1.5
Height 2.8 53.4 98.0 -7.4 -9.9 -9.3 -8.1 -3.5 -1.3
Waist Hip Ratio (WHR) 1.4 6.2 12.5 3.5 3.2 2.8 1.9 -1.1 1.1
Systolic Blood Pressure 10.9 54.3 116.6 7.8 10.4 10.8 6.2 0.1 1.3
Smoking Status 0.1 0.3 0.7 0.6 -0.3 -0.2 0.8 -0.7 0.6
Allergy or Eczema 1.2 3.1 5.5 -1.4 -2.3 -2.4 -2.3 0.3 -0.6
Cardiovascular Disease 3.4 11.1 24.9 3.4 4.5 5.0 2.8 0.5 -1.1
Hypothyroidism (self reported) 1.9 4.3 7.1 -2.7 -2.4 -2.5 -1.7 -0.8 -1.8
Respiratory disease 2.1 4.7 7.3 -2.2 -2.4 -2.7 -2.6 -1.6 -0.9
Type 2 Diabetes (T2D) (2018) 0.1 0.3 0.6 0.4 -0.3 -0.8 0.6 0.6 -0.1
Lung FEV1/FVC ratio 0.2 1.0 2.9 0.1 1.1 0.9 -0.2 -1.7 0.9
Lung FVC 1.5 7.5 15.1 3.9 2.7 2.7 3.0 -0.3 2.4
Neuroticism 0.7 1.7 6.4 0.4 0.4 0.5 -1.7 -2.5 -0.7
Chronotype (morning person) 0.8 1.8 3.6 1.3 1.9 1.8 1.1 0.6 0.8
Hair Pigment 0.3 8.9 30.4 -0.5 2.6 2.6 -0.2 -5.5 -3.1
Tanning 0.3 3.4 8.4 -1.4 -2.8 -2.9 -1.2 0.0 -1.0
Hand grip strength (left) 0.7 1.9 4.2 -0.4 -1.7 -1.7 -1.0 0.3 2.0
Number of treatments/medications taken 0.5 0.9 2.8 -0.1 0.4 0.0 1.0 1.7 -1.2
Average weekly spirits intake 0.3 0.3 0.9 0.9 0.7 0.3 0.0 -0.3 0.6
Sensitivity / hurt feelings 0.7 1.1 3.4 0.8 -0.4 -0.3 -1.8 -1.1 1.2
Frequency of depressed mood in last 2 weeks 0.8 1.1 1.8 1.3 1.0 1.3 -0.2 -1.3 0.7
Hearing difficulty/problems: Yes 0.1 0.2 0.3 -0.6 -0.4 -0.3 0.2 0.5 0.5
Relative age of first facial hair 0.4 0.9 1.4 -1.2 -1.0 -0.9 -1.2 -0.6 0.6
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.2 0.6 0.7 0.4 0.9 1.5 -0.8
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.0 -0.7 -1.0 -0.6 -0.5 -0.0 -0.2
Ever had hysterectomy (womb removed) 2.0 2.2 4.3 -1.6 -1.4 -1.7 -2.1 0.1 -1.3
Systolic blood pressure, automated reading 12.1 35.1 74.8 5.9 8.3 8.7 5.5 0.4 1.0
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.5 0.3 0.7 0.4 0.8 -0.5 -1.2
Angina 0.2 0.2 0.8 0.3 0.2 0.4 0.0 -0.9 -0.6
Medication for hormone replacement therapy 0.4 0.4 1.1 -0.4 0.0 -0.1 -0.6 -1.0 -1.0
Vitamin and mineral supplements 0.4 0.5 1.5 -1.2 -0.4 -0.3 -0.0 -0.3 -1.1
Supplements: Zinc 0.2 0.2 0.6 -0.2 -0.7 -0.4 0.3 0.8 -0.2
Medication: Co-codamol 0.3 0.4 0.9 -0.6 -0.2 -0.8 -0.2 0.6 -0.9
Medication: Metformin 0.9 1.3 2.7 -1.0 -1.5 -1.6 0.0 1.2 -0.8
Diabetes (father) 2.9 3.5 7.9 1.9 1.1 0.7 2.8 2.6 1.2
Diabetes (mother) 1.7 2.1 3.4 -0.9 -1.9 -1.3 -1.7 -1.0 -1.7
Severe depression (siblings) 2.1 2.4 7.7 2.8 1.8 1.7 0.3 0.0 0.5
Pack years adult smoking proportion 0.4 0.6 1.9 0.8 0.3 0.1 1.4 0.6 -0.6
Impedance of leg (right) 1.5 7.3 12.5 3.1 3.3 3.5 2.1 -0.2 2.5
Leg fat-free mass (left) 3.4 18.0 32.8 -4.5 -5.5 -5.7 -4.6 -1.1 -1.6
Trunk fat percentage 0.1 0.2 0.8 -0.4 -0.1 -0.3 -0.2 -0.5 -0.9
Hand grip strength (right) 0.7 1.9 9.1 0.2 -1.0 -0.8 -0.6 0.1 3.0
Townsend deprivation index at recruitment 0.8 1.2 4.8 -0.8 0.0 0.3 1.1 -0.5 -2.2
Current tobacco smoking 0.1 0.2 0.5 0.4 0.7 0.2 0.7 0.0 0.0
Average weekly fortified wine intake 0.8 0.9 1.5 -0.2 -1.1 -1.2 -1.1 0.1 1.2
Maternal smoking around birth 0.2 0.3 0.7 -0.2 -0.7 -0.4 0.8 0.6 -0.5
Fed-up feelings 0.2 0.5 1.3 -0.3 -0.5 -0.2 -1.1 -0.9 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.3 0.4 0.6 0.6 -0.5 -0.2 0.2
Relative age voice broke 0.2 0.3 0.8 -0.4 -0.5 -0.1 -0.6 0.9 0.6
Taking other prescription medications 0.2 0.4 0.8 0.9 0.7 0.6 0.6 0.0 -0.3
Age when periods started (menarche) 0.6 1.4 2.1 -1.4 -1.2 -1.3 -0.8 -1.0 -1.3
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.1 -0.0 0.6 0.8 -0.7 -1.1 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 8.6 19.6 34.5 5.2 5.8 5.9 3.4 -0.5 3.3
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.3 0.1 0.1 0.0 0.1 0.4 -0.6
Qualifications: CSEs or equivalent 0.1 0.1 0.3 -0.5 -0.1 -0.1 0.6 -0.3 -0.3
Serious illness, injury or assault to yourself 1.1 1.4 2.5 -1.2 -1.6 -1.5 -1.1 0.9 -0.3
High blood pressure 3.6 10.0 22.1 3.3 4.2 4.7 2.9 0.5 -0.4
Hayfever, allergic rhinitis or eczema 2.2 4.8 9.1 -1.7 -2.7 -3.0 -3.0 0.1 -0.7
Multivitamins +/- minerals 0.8 1.0 1.8 0.2 -0.9 -1.1 -1.2 0.9 1.3
Stomach or abdominal pain in last month 0.2 0.2 0.6 0.3 0.8 0.1 0.4 -0.3 0.5
Supplements: Glucosamine 0.5 0.7 1.8 0.3 0.4 0.7 0.7 1.0 1.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.4 -0.7 0.1 -0.0 -0.6 -0.9 -1.2
Medication: Atenolol 0.8 1.0 4.0 -0.5 -0.9 -0.7 0.3 2.0 -0.3
Medication: Levothyroxine sodium 2.9 5.0 9.9 -3.1 -2.6 -2.5 -1.6 0.1 -2.1
Sitting height 1.2 8.4 15.1 -2.4 -3.9 -3.5 -3.9 -1.4 0.6
Chronic bronchitis/emphysema (father) 0.4 0.5 1.1 -0.3 0.9 0.8 1.0 -0.0 -0.6
High blood pressure (mother) 0.6 0.8 2.1 0.0 1.0 1.4 -0.9 -1.0 -0.5
Body mass index (BMI) 0.2 0.7 2.2 -1.0 -0.5 -0.7 -0.3 0.0 -1.5
Impedance of leg (left) 1.6 7.7 14.2 3.3 3.4 3.8 2.2 -0.4 2.1
Leg predicted mass (left) 3.5 18.3 33.3 -4.5 -5.5 -5.8 -4.7 -1.1 -1.6
Trunk fat mass 0.3 1.4 2.2 -1.2 -1.3 -1.5 -1.3 -0.8 -1.1
Waist circumference 0.1 0.5 2.1 -0.0 0.2 -0.2 -0.5 -1.5 -0.9
Number of incorrect matches in round 0.4 0.7 1.4 -0.1 1.1 1.1 -0.1 0.8 -1.2
Past tobacco smoking 0.5 0.9 1.9 1.1 1.2 1.0 -0.1 1.4 0.0
Alcohol usually taken with meals 0.4 0.6 1.0 -1.0 -1.0 -0.9 -0.8 0.4 0.2
Nervous feelings 0.5 0.9 2.7 -0.3 -0.3 -0.0 -1.6 -1.3 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.7 1.3 1.0 0.9 -0.1 -0.2 1.0
Hearing difficulty/problems with background noise 0.8 1.3 3.9 -0.5 -0.5 -0.2 2.0 1.8 -0.1
Hair/balding pattern: Pattern 2 0.7 0.9 1.7 -0.8 -1.2 -1.3 -0.8 0.1 -1.0
Had menopause 0.6 0.8 1.7 0.7 0.2 0.5 1.2 1.3 0.8
Had other major operations 2.5 3.1 7.8 -1.4 -2.6 -2.8 -1.2 0.5 -0.3
Forced vital capacity (FVC) 0.7 2.6 6.2 1.0 -0.9 -0.7 -1.7 -2.5 2.0
Heel bone mineral density (BMD) T-score, automated (right) 8.4 19.2 34.5 5.1 5.6 5.9 3.9 0.2 3.0
Ever unenthusiastic/disinterested for a whole week 1.3 1.5 3.6 -1.2 -1.9 -1.7 -0.5 1.0 -0.4
Qualifications: None of the above 0.5 1.1 1.9 -0.0 1.2 1.1 1.4 -0.4 -1.3
Financial difficulties in last 2 years 0.7 1.0 1.8 1.3 0.9 0.8 1.3 0.4 1.0
Mouth/teeth dental problems 0.5 0.7 1.9 -0.0 -0.8 -0.7 -1.4 -0.1 1.2
Heart attack 0.9 1.2 2.4 -1.5 -1.5 -1.3 0.0 0.6 -0.6
Allergy 3.6 8.2 16.1 2.4 3.4 3.7 4.0 0.4 1.1
Pain all over the body in last month 1.0 1.0 4.0 1.1 -0.2 -0.3 0.7 2.0 0.6
Diabetes (self-reported) 0.2 0.3 0.8 -0.4 -0.3 -0.8 0.1 0.1 -0.9
Hayfever/allergic rhinitis (self-reported) 2.7 3.6 7.0 -2.1 -1.9 -1.7 -2.6 -1.4 -1.3
Medication: Ramipril 0.8 1.0 5.2 -0.0 0.4 0.5 -0.1 0.4 -2.3
Medication: Simvastatin 1.2 1.8 5.0 0.9 1.6 1.4 2.2 0.8 -0.3
Fluid intelligence score 0.7 1.4 2.5 -0.8 -1.4 -1.4 -0.9 -0.7 1.6
Illnesses of siblings 3.8 5.3 9.9 -1.7 -2.8 -3.1 -2.9 -0.8 -1.3
Neuroticism score 0.7 1.5 4.6 0.4 -0.3 -0.1 -2.1 -2.1 0.0
Weight 1.3 6.6 11.3 -2.7 -3.3 -3.4 -2.8 -0.9 -1.3
Impedance of arm (right) 0.3 1.3 2.1 1.2 1.4 1.4 1.4 0.1 0.4
Arm fat percentage (right) 0.1 0.4 1.7 -0.5 0.3 -0.1 0.6 0.3 -1.3
Trunk fat-free mass 2.9 16.6 28.2 -4.4 -5.3 -5.3 -4.4 -1.6 -1.4
Hip circumference 1.2 5.0 7.1 -2.5 -2.4 -2.7 -2.6 -1.2 -1.6
Time employed in main current job 1.9 2.2 5.1 0.7 1.6 1.4 2.3 1.2 -1.3
Alcohol intake versus 10 years previously 1.2 1.9 7.5 -1.0 -0.1 -0.1 1.2 -1.1 -2.7
Father’s age at death 0.8 1.0 3.4 -1.9 -0.6 -0.2 -0.3 0.2 -1.5
Worrier / anxious feelings 0.8 1.5 4.9 2.2 1.3 1.2 -0.3 0.2 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.4 1.2 0.9 0.9 0.3 -0.3 0.2
Falls in the last year 0.3 0.3 1.2 0.1 -0.7 -0.6 0.2 1.1 -0.0
Hair/balding pattern: Pattern 3 0.6 0.8 1.5 0.9 1.2 1.2 0.9 0.7 0.3
Number of live births 1.0 1.4 3.2 -1.0 -1.1 -1.2 1.0 1.8 0.1
Forced expiratory volume in 1-second (FEV1) 0.7 2.5 8.0 1.3 -0.0 -0.0 -1.3 -2.8 1.8
Pulse rate 1.8 3.0 6.3 -1.7 -2.2 -1.9 -2.5 -0.5 -0.4
Happiness 0.3 0.4 2.0 -0.3 0.0 0.2 0.1 -0.3 -1.4
Noisy workplace 0.5 0.7 1.2 0.5 0.9 1.0 0.3 -0.8 -1.1
Qualifications: A levels/AS levels or equivalent 0.5 1.0 2.3 -0.3 -1.5 -1.4 -1.3 -0.5 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.5 -0.9 -1.2 -1.2 -0.7 0.4 0.1
Mouth/teeth dental problems: Dentures 0.2 0.4 1.9 -0.4 -0.1 -0.0 0.2 -0.4 -1.4
Asthma 1.5 2.9 4.3 -2.1 -1.6 -1.8 -2.0 -1.1 -1.5
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.2 0.1 0.5 0.4 -0.3 -0.8 -1.1
Medication: Cholesterol lowering 1.5 2.3 5.1 1.3 1.6 1.6 2.3 1.3 0.2
Depression (self-reported) 0.4 0.5 0.9 0.9 1.0 0.8 -0.3 -0.5 -0.4
Medication: Lansoprazole 0.2 0.2 1.1 0.0 -0.2 -0.4 -0.2 0.1 1.1
Prospective memory result 0.8 1.0 2.8 0.1 0.9 0.5 1.2 1.7 -1.0
Lung cancer (father) 1.4 1.6 3.1 -0.7 -1.6 -1.6 -1.8 -0.7 -0.6
Illnesses of mother 1.4 1.7 4.3 -0.2 -1.6 -2.1 0.1 0.6 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.5 5.8 1.2 -0.7 -0.9 -1.3 -2.1 2.4
Pulse wave Arterial Stiffness index 0.3 0.4 1.7 0.5 -0.2 0.1 0.2 0.5 1.3
Impedance of arm (left) 0.5 2.4 3.9 1.8 2.0 2.0 1.4 0.2 1.2
Arm fat mass (right) 0.5 2.2 3.7 -1.9 -1.4 -1.7 -1.0 -0.5 -1.8
Trunk predicted mass 2.8 16.2 27.7 -4.3 -5.3 -5.2 -4.3 -1.6 -1.5
Standing height 2.0 19.9 36.5 -3.9 -6.0 -5.7 -5.5 -2.2 0.1
Length of working week for main job 0.3 0.3 0.7 -0.4 0.6 0.4 0.9 0.6 -0.4
Exposure to tobacco smoke at home 0.5 0.5 2.5 -0.1 0.1 -0.2 0.4 0.5 -1.6
Breastfed as a baby 0.1 0.1 0.4 -0.6 0.2 0.5 0.2 0.0 -0.2
Tense / ‘highly strung’ 0.6 1.0 1.7 1.3 1.2 1.2 0.9 -0.5 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.9 0.4 -0.3 -0.3 -0.9 -0.0 1.0
Hair/balding pattern: Pattern 4 0.2 0.4 1.1 0.7 0.6 0.7 1.0 -0.1 0.3
Birth weight of first child 1.9 3.4 8.0 -2.1 -2.6 -2.8 -0.3 -0.3 -1.0
Peak expiratory flow (PEF) 0.6 1.3 4.0 0.9 0.9 0.6 -0.4 -2.0 1.4
Pulse wave reflection index 0.8 1.0 2.6 0.7 0.3 0.3 1.1 1.1 1.6
Ever highly irritable/argumentative for 2 days 1.3 1.6 2.9 -1.7 -0.8 -1.0 -1.5 -0.1 -1.7
Loud music exposure frequency 3.1 3.4 6.1 -2.0 -2.5 -2.5 -2.0 -0.2 0.1
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.5 0.8 -0.3 -0.4 0.4 1.2 1.1
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 2.5 1.1 0.8 0.8 0.9 1.6 1.2
Blood clot in the leg (DVT) 1.9 2.4 5.5 -1.6 -2.2 -2.3 -0.9 0.8 0.1
Medication: Paracetamol 0.4 0.6 2.1 0.5 0.9 0.6 1.5 0.2 -0.2
Headache pain in last month 0.8 1.4 6.4 -0.9 -0.1 -0.5 -0.9 -0.0 -2.5
Medication for cholesterol, blood pressure or diabetes 2.2 3.6 6.9 -1.6 -2.3 -2.2 -2.6 -1.3 0.5
Glaucoma (self-reported) 0.7 0.8 2.0 1.1 0.9 1.4 0.5 -0.4 0.3
Gout (self-reported) 0.5 0.6 2.4 0.1 -0.2 -0.0 0.4 1.6 1.0
Hypothyroidism/myxoedema (self-reported) 1.2 2.4 4.4 -2.1 -1.8 -1.8 -1.1 0.1 -1.4
Medication: Amlodipine 0.8 1.1 2.4 1.0 1.5 1.6 -0.4 -0.7 -0.0
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.4 0.8 -0.5 -0.7 -0.5 -0.6 1.2
Birth weight 1.2 2.6 6.1 -0.7 -2.5 -2.4 -1.7 -0.5 -0.8
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.4 -0.2 0.4 0.2 0.5 0.1 -1.2
High blood pressure (siblings) 4.0 5.8 10.7 2.5 3.0 3.3 2.3 0.7 1.8
Forced vital capacity (FVC), Best measure 0.9 3.2 8.2 1.2 -1.3 -1.4 -1.4 -2.0 2.9
Body fat percentage 0.0 0.1 0.3 0.2 0.5 0.3 0.3 -0.2 -0.6
Leg fat percentage (right) 0.2 0.9 1.5 1.0 1.2 1.2 1.1 0.3 0.4
Arm fat-free mass (right) 2.5 13.0 22.1 -3.7 -4.7 -4.6 -4.2 -1.4 -1.1
Exposure to tobacco smoke outside home 0.7 1.0 4.2 -0.0 -0.5 -0.7 1.0 2.1 -0.2
Comparative body size at age 10 0.2 0.7 1.0 0.9 0.4 0.9 0.6 0.9 -1.0
Number of full brothers 0.8 1.0 2.6 -0.9 -0.6 -0.3 1.1 1.6 -0.9
Worry too long after embarrassment 1.2 2.1 6.9 -1.1 -0.9 -0.7 -1.7 -2.6 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 2.5 -0.3 -0.7 -0.8 -0.2 1.6 0.7
Wheeze or whistling in the chest in last year 0.0 0.0 0.2 0.1 -0.0 0.1 -0.2 0.5 0.0
Number of children fathered 2.9 3.2 6.5 1.8 2.3 2.5 1.9 0.6 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 4.2 2.1 0.4 0.4 -0.6 -0.4 1.2
Age at first live birth 0.5 0.8 3.0 0.9 0.6 0.4 -0.8 -1.7 0.0
Pulse wave peak to peak time 0.3 0.4 1.6 -0.7 0.0 -0.3 -0.2 -0.4 -1.3
Health satisfaction 0.1 0.1 0.2 -0.3 -0.5 -0.4 -0.1 0.4 -0.3
Shortness of breath walking on level ground 0.8 1.0 2.8 -0.2 -0.9 -1.1 -1.7 -0.9 0.6
Qualifications: College or University degree 0.2 0.6 2.3 1.0 -0.0 0.0 0.3 0.7 1.5
Eye problems/disorders: None of the above 0.4 0.5 2.1 -0.7 0.0 -0.1 0.2 -0.5 -1.4
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.2 -0.9 -0.6 -0.8 0.9 1.5 -1.4
Emphysema/chronic bronchitis 0.6 0.7 2.6 0.2 -0.7 -0.8 -1.6 -0.7 -0.0
Medication for pain relief, constipation, heartburn 0.3 0.5 1.1 -0.8 -0.8 -0.6 -0.4 -0.0 1.1
Neck or shoulder pain in last month 0.1 0.2 0.4 -0.6 -0.6 -0.3 -0.3 0.4 0.2
Medication: Blood pressure 3.0 5.3 9.2 2.2 3.0 3.0 2.8 1.1 -0.4
Angina (self-reported) 0.3 0.4 1.3 0.3 0.3 0.5 0.1 -1.1 -0.9
Migraine (self-reported) 1.0 1.2 5.1 0.0 0.9 0.8 0.7 -0.5 -2.3
Medication: Ibuprofen 0.3 0.3 1.7 -0.5 0.2 0.0 -0.0 0.3 -1.3
Medication: Allopurinol 0.8 1.1 3.1 -0.2 0.0 0.1 1.4 1.8 1.2
Medication: Omeprazole 0.5 0.6 1.7 0.7 0.8 0.7 0.2 -0.1 -1.3
Medication: Seretide 50 evohaler 0.4 0.4 1.0 0.5 0.9 1.0 -0.3 -0.5 -0.6
Mean time to correctly identify matches 0.2 0.3 1.0 -1.0 -0.4 -0.1 -0.6 0.0 -0.5
Heart disease (mother) 0.9 1.1 2.5 0.0 0.8 1.0 -1.3 -1.6 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.7 2.8 -0.3 0.7 0.5 0.2 0.5 -1.7
Whole body fat mass 0.3 1.4 2.3 -1.3 -1.3 -1.5 -1.0 -0.4 -1.2
Leg fat mass (right) 0.2 0.7 1.4 -0.9 -1.0 -1.2 -0.9 -0.2 -0.4
Arm predicted mass (right) 2.4 12.3 19.6 -3.7 -4.4 -4.4 -4.2 -1.4 -1.4
Pulse rate, automated reading 0.1 0.4 1.9 0.5 0.3 -0.3 -1.4 -0.2 0.3
Alcohol intake frequency. 1.0 2.2 9.1 -1.8 -0.5 -0.8 0.5 -0.0 -3.0
Comparative height size at age 10 0.8 4.5 7.5 -1.6 -2.7 -2.5 -2.5 -2.1 -0.1
Number of full sisters 1.0 1.2 2.3 -0.9 -1.2 -1.5 -1.1 -0.8 -0.9
Suffer from ‘nerves’ 0.5 0.8 2.0 0.9 1.1 1.4 -0.4 -0.7 -0.7
Overall health rating 0.2 0.4 1.1 0.6 0.5 0.4 0.3 1.1 0.5
Chest pain or discomfort 0.8 1.1 2.6 0.5 1.1 1.6 -0.2 -1.5 -0.4
Had major operations 0.8 0.9 1.9 -1.2 -1.0 -1.0 0.1 1.4 0.4
Age at last live birth 0.5 0.8 2.1 0.2 1.0 0.9 -0.0 -0.8 -1.4
Family relationship satisfaction 0.2 0.2 0.8 0.1 -0.4 -0.3 0.9 0.3 -0.3
Leg pain on walking 0.6 0.8 1.9 -1.4 0.1 0.1 -0.7 -1.3 -0.8
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 3.0 -1.5 -1.7 -1.7 -0.9 0.0 -0.9
Commuting to job workplace: Car/motor vehicle 2.4 2.8 5.4 2.0 2.3 2.2 1.6 0.2 -0.1
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.1 0.8 1.0 0.8 0.4 0.5 -0.3
Medication: Aspirin 1.6 2.1 4.1 1.7 2.0 2.0 1.2 0.7 0.4
Supplements: Vitamin C 0.5 0.6 1.0 1.0 1.0 1.0 0.5 -0.3 -0.5
Knee pain experienced in last month 0.3 0.5 2.6 -0.0 0.5 0.3 0.2 1.6 0.3
Hypertension (Self-reported) 3.4 9.3 19.8 3.1 4.0 4.5 3.1 1.0 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.9 0.9 1.4 1.0 0.3 -0.1 -0.6
Illnesses of father: Heart disease 1.1 1.6 2.9 1.7 0.8 1.1 0.7 -1.3 1.5
Illnesses of siblings: Diabetes 0.9 1.2 2.6 0.2 1.5 1.6 0.7 -0.8 -1.0
Smoking status: Previous 0.2 0.3 0.5 -0.1 -0.7 -0.3 0.6 -0.7 0.4
Forced expiratory volume in 1-second (FEV1), predicted 3.2 6.6 13.4 -2.1 -3.2 -3.2 -3.7 -0.8 0.1
Whole body fat-free mass 3.2 18.4 32.0 -4.5 -5.6 -5.7 -4.7 -1.4 -1.6
Leg fat-free mass (right) 3.5 18.9 33.5 -4.6 -5.6 -5.8 -4.7 -1.3 -1.8
Arm fat percentage (left) 0.1 0.3 1.1 -0.4 0.4 0.1 0.5 0.3 -1.1
Average weekly red wine intake 0.8 1.2 5.0 0.4 -0.7 -0.5 -0.4 2.2 1.1
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.9 -0.3 -0.5 -0.9 -1.0 -0.4 -0.1
Mood swings 0.1 0.2 0.4 0.5 0.1 0.0 -0.6 -0.6 0.1
Loneliness, isolation 0.6 0.8 1.9 -0.7 -1.3 -1.4 -0.8 0.3 -0.3
Long-standing illness, disability or infirmity 0.9 1.4 3.2 1.1 0.6 0.5 1.6 1.8 0.8
Ever had bowel cancer screening 0.8 0.9 2.0 0.5 1.1 1.4 1.2 0.4 -0.5
Diabetes diagnosed by doctor 0.2 0.3 1.0 -0.2 -0.6 -1.0 0.1 0.1 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 3.9 0.4 1.1 0.8 -0.1 -2.0 0.6
Friendships satisfaction 0.4 0.4 2.0 0.1 0.4 0.3 1.4 0.5 0.4
Qualifications: nursing, teaching 0.2 0.3 0.6 0.5 -0.5 -0.8 -0.0 -0.1 0.8
Commuting to job workplace: Walk 1.5 1.6 6.2 0.6 0.0 -0.0 1.3 1.3 2.5
Eye problems/disorders: Cataract 1.0 1.1 3.5 0.1 -0.8 -0.6 -0.3 1.5 1.9
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 2.5 0.4 1.1 1.0 1.6 0.4 -0.8
Medication for cholesterol 0.2 0.4 0.8 -0.1 0.0 -0.2 0.9 0.7 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.3 -0.4 -0.6 -0.3 -0.3 0.1 0.0
Back pain experienced in last month 1.4 2.0 4.0 -1.5 -2.0 -1.8 -1.0 0.7 1.1
Mineral and other dietary supplements 0.9 1.2 5.3 -0.4 0.6 0.3 0.2 -1.2 -2.3
Breast cancer (self-reported) 1.5 1.8 4.0 -1.0 -1.4 -1.5 -1.1 -0.2 -2.0
Asthma (self-reported) 1.1 2.3 3.4 -1.8 -1.4 -1.7 -1.8 -0.9 -1.2
Osteoporosis (self-reported) 0.8 0.9 3.0 1.2 0.3 0.2 -0.8 -1.7 0.7
Osteoarthritis (self-reported) 0.9 1.1 2.8 0.2 1.0 1.1 1.7 1.1 -0.8
Medication: Aspirin 1.2 1.5 2.9 1.5 1.7 1.7 0.9 0.4 0.5
Medication: Gliclazide 0.3 0.4 0.7 0.3 -0.5 -0.8 -0.0 0.8 0.8
Illnesses of father: None of the above (group 1) 2.6 3.2 6.5 -2.5 -2.0 -1.9 -1.6 0.1 -1.6
Smoking status: Current 0.1 0.1 0.2 0.1 0.3 -0.2 0.5 -0.5 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.0 4.3 8.5 2.9 1.9 1.7 1.2 -1.6 2.6
Whole body water mass 3.2 18.1 30.9 -4.6 -5.5 -5.6 -4.6 -1.5 -1.7
Leg predicted mass (right) 3.5 18.8 33.3 -4.6 -5.6 -5.8 -4.7 -1.2 -1.9
Arm fat mass (left) 0.5 2.1 3.5 -1.9 -1.4 -1.7 -1.1 -0.4 -1.7
Number of self-reported non-cancer illnesses 0.8 1.3 3.0 1.2 1.6 1.7 0.0 -0.3 -0.9
Average weekly champagne plus white wine intake 0.9 1.3 3.9 -0.4 -1.1 -0.8 -2.0 -1.1 0.6
Miserableness 0.2 0.3 0.7 0.8 0.4 0.5 -0.5 0.8 0.0
Guilty feelings 0.6 0.9 1.9 -0.6 -0.7 -0.6 -1.4 -1.4 -0.5
Wears glasses or contact lenses 1.0 1.1 2.0 0.9 1.4 1.4 -0.3 -0.7 1.2
Ever taken oral contraceptive pill 1.1 1.2 2.2 -1.5 -1.4 -1.3 -1.0 -0.2 0.5
Hearing aid user 0.2 0.2 1.0 -0.2 -0.1 -0.4 0.2 1.0 0.3
Mother’s age at death 0.9 1.1 2.6 0.8 1.2 1.2 0.5 -1.6 0.2
Financial situation satisfaction 0.3 0.4 0.7 -0.5 -0.8 -0.7 0.5 0.8 0.1
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.5 -0.5 0.6 0.5 1.2 -0.5 -0.8
Commuting to job workplace: Public transport 1.4 1.7 3.8 -1.2 -1.4 -1.6 -1.9 -0.4 0.2
Eye problems/disorders: Glaucoma 0.3 0.4 0.7 0.7 0.4 0.7 -0.5 -0.3 0.8
Medication: Blood pressure 0.1 0.2 0.6 0.6 0.5 0.8 0.1 0.3 -0.2
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.4 -0.1 1.2 1.1 0.9 0.4 -0.9
Supplements: Fish oil (including cod liver oil) 0.7 1.0 4.7 0.6 0.2 0.4 -0.0 0.7 2.2
High cholesterol (Self-reported) 1.9 3.3 6.1 2.0 2.4 2.5 2.0 0.5 0.1
Medication: Bendroflumethiazide 3.5 5.3 9.4 3.0 3.1 2.9 1.8 0.1 1.3
Medication: Paracetamol 1.4 2.2 6.5 1.2 1.5 1.1 2.6 1.3 0.2
Medication: Lisinopril 2.7 3.5 5.8 2.3 2.1 2.2 2.4 0.6 0.5
Medication: Atorvastatin 0.2 0.2 0.5 0.0 0.0 0.4 0.3 0.6 -0.7
Illnesses of father: High blood pressure 8.9 11.0 20.4 3.7 4.5 4.2 2.9 0.7 2.3
Alcohol drinker status: Never 0.9 1.1 3.7 -0.5 -0.1 -0.0 1.2 1.9 -1.2
Ever smoked 1.4 2.4 4.2 -2.1 -2.0 -1.9 -0.9 -1.2 -0.4
Basal metabolic rate 3.0 16.7 28.6 -4.4 -5.3 -5.3 -4.4 -1.4 -1.8
Leg fat percentage (left) 0.2 0.6 1.2 0.9 1.1 1.1 0.8 0.0 -0.1
Arm fat-free mass (left) 2.7 13.7 22.4 -4.0 -4.7 -4.7 -4.1 -1.6 -1.6
Number of operations (self-reported) 3.5 5.2 10.4 -2.7 -3.0 -3.2 -1.9 -0.5 -0.8
Average weekly beer plus cider intake 0.2 0.3 0.7 0.7 0.6 0.3 0.8 0.5 -0.2
Irritability 0.5 0.8 2.8 -0.2 -0.2 -0.3 -1.3 -1.7 0.6
Risk taking 0.2 0.3 0.6 0.4 0.7 0.4 0.3 0.6 0.8
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.8 -0.5 -0.9 -0.8 0.5 1.7 1.0
Fractured/broken bones in last 5 years 0.3 0.3 0.7 -0.7 -0.8 -0.9 -0.2 -0.3 0.2
Age started oral contraceptive pill 0.8 1.0 2.1 1.1 0.8 1.0 1.5 1.0 0.6
Diastolic blood pressure, automated reading 3.1 9.7 21.8 3.1 4.7 4.7 2.0 -0.6 0.4
Ever depressed for a whole week 0.1 0.2 0.5 0.1 -0.7 -0.4 -0.2 -0.2 -0.5
Unable to work because of sickness or disability 0.8 1.1 2.1 0.4 1.5 1.4 0.9 0.7 -0.9
Commuting to job workplace: Cycle 2.5 3.0 5.5 -2.0 -0.4 -0.1 -1.9 -2.3 -2.3
Myopia 0.3 0.5 1.2 0.2 -0.7 -0.6 -0.8 1.1 0.4
Vascular/heart problems diagnosed by doctor 2.4 6.5 15.0 -2.6 -3.4 -3.9 -2.4 -0.3 0.4
Cholesterol lowering medication 0.0 0.0 0.1 0.2 -0.3 -0.2 0.1 0.1 0.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 1.1 0.7 0.3 0.2 -0.5 0.1 -1.1
Pain experienced in last month 0.2 0.4 0.9 0.7 0.4 0.8 1.0 -0.5 0.1
Supplements: Calcium 1.6 1.7 3.0 -1.7 -1.4 -1.6 -1.6 -0.3 -0.3
Basal cell carcinoma (self-reported) 1.4 1.7 6.0 1.4 0.0 0.3 -1.2 -2.4 1.0
Heart attack/myocardial infarction (self-reported) 1.6 2.0 4.2 -2.0 -1.9 -1.7 -0.3 0.4 -1.1
Deep venous thrombosis (DVT) (self-reported) 2.4 3.1 7.0 -1.9 -2.4 -2.6 -1.2 0.6 -0.3
Heart disease (siblings) 0.8 0.9 2.5 -0.4 0.8 1.1 1.6 1.1 0.2
Alcohol drinker status: Previous 1.7 1.9 3.3 -1.6 -1.8 -1.5 -1.3 -0.2 -1.2
Pack years of smoking 0.4 0.5 1.9 0.8 0.3 0.2 1.4 0.4 -0.6
Impedance of whole body 1.0 5.1 9.1 2.7 2.9 3.0 1.8 -0.3 1.6
Leg fat mass (left) 0.2 0.8 1.5 -0.9 -1.1 -1.2 -0.9 -0.2 -0.6
Arm predicted mass (left) 3.0 15.2 24.2 -4.3 -4.9 -4.9 -4.3 -1.7 -1.7