Hub : Genes

RP3-402G11.27

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.075 0.030 0.0025 0.002 NA 0.002 NA 0.006 0.20 NA 0.2000 NA 0.10
2 GTEx Heart Atrial Appendage 0.156 0.065 0.0071 0.000 NA 0.049 NA 0.008 0.31 NA 0.0031 NA 0.13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.3 2.1 2.5 1.3 1.6
Bipolar Disorder or Schizophrenia 1.9 4.6 9.0 0.3 3.0
Depressed Affect (Nagel 2018) 0.1 0.3 0.4 0.4 -0.7
Depression (Nagel 2018) 0.2 0.3 0.5 -0.2 0.7
Intelligence (Savage-Jansen 2018) 1.8 5.6 11.0 0.4 -3.3
Neuroticism (Nagel 2018) 0.2 0.5 0.9 0.9 -0.4
Schizophrenia (2018) 2.1 4.3 8.2 -0.7 2.9
Schizophrenia vs Biploar Disorder 0.4 0.6 1.1 -1.1 -0.2
Worry (Nagel 2018) 0.3 0.6 1.0 0.4 1.0
Alzheimer’s Disease (in mother) 1.4 1.6 3.2 -1.8 0.2
Alzheimer’s Disease (in father) 1.0 1.0 2.0 0.2 -1.4
Alzheimer’s Disease (including proxy) 0.2 0.2 0.3 -0.5 -0.4
Crohns Disease (2017) 0.2 0.5 0.9 0.9 -0.2
Irritable Bowel Disease (IBD) 0.1 0.2 0.4 0.7 -0.1
Ulcerative Colitis (UC) 0.0 0.0 0.0 0.2 0.0
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.9 1.7 1.8 -1.4 1.3
Verbal and Numeric Reasoning (VNR) 2.9 7.0 11.7 1.5 -3.4
Breast Cancer 0.0 0.1 0.1 -0.3 -0.2
Ovarian Cancer 0.9 1.2 1.9 -0.8 -1.4
Prostate Cancer 0.6 0.8 1.6 -1.3 0.1
Age at First Birth 0.5 0.7 0.9 0.9 0.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.6 1.2 -0.2 1.1
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.2 0.2 0.3 0.6 0.4
Mean Putamen Volume 0.1 0.1 0.1 -0.4 -0.1
Fasting Glucose 1.1 1.3 2.5 0.1 1.6
HbA1C 1.8 1.9 2.4 1.2 1.6
HDL Cholesterol 0.4 0.7 1.1 -1.1 0.5
LDL Cholesterol 1.6 2.5 3.8 -1.9 1.1
Lupus 0.5 0.8 0.8 0.9 -0.9
Neuroticism (2016) 0.8 1.2 1.4 1.0 1.2
Primary Biliary Cirrhosis 1.1 1.6 3.2 0.1 1.8
Rheumatoid Arthritis 0.8 1.1 1.5 1.2 0.8
Schizophrenia (2014) 1.3 2.8 4.9 -0.9 2.2
Triglycerides 0.2 0.4 0.5 -0.5 -0.7
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.5 -1.2 0.4
Ulcerative Colitis 0.6 0.9 1.8 -0.0 1.3
Blood Eosinophil Count 0.8 6.4 10.1 -1.6 -3.2
Blood Platelet Count 0.5 5.7 9.8 -3.1 -1.2
Blood Red Count 2.1 20.3 31.2 3.1 -5.6
Blood White Count 0.2 1.3 2.0 1.4 -0.7
Heel T-Score 0.6 4.7 9.2 3.0 0.5
BMI 0.1 0.8 0.9 0.8 1.0
Height 0.1 1.5 2.2 -0.9 1.5
Waist Hip Ratio (WHR) 0.7 3.3 6.6 0.2 -2.6
Systolic Blood Pressure 0.6 3.1 4.0 2.0 -1.5
Smoking Status 1.7 4.0 4.7 2.2 -1.8
Allergy or Eczema 0.4 1.0 1.8 -0.5 -1.4
Cardiovascular Disease 0.3 1.0 2.0 -0.1 1.4
Hypothyroidism (self reported) 0.3 0.6 1.0 -1.0 -0.5
Respiratory disease 0.4 0.8 1.2 -0.7 -1.1
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.5 -0.7 -0.4
Lung FEV1/FVC ratio 0.2 0.9 1.8 -0.1 1.4
Lung FVC 0.5 2.7 4.1 -2.0 -1.1
Neuroticism 0.8 2.0 2.4 1.2 -1.6
Chronotype (morning person) 0.8 1.8 3.4 1.8 0.4
Hair Pigment 0.1 4.0 8.0 -0.2 2.8
Tanning 0.1 1.6 3.1 0.3 -1.8
Hand grip strength (left) 0.4 1.2 2.3 0.1 -1.5
Number of treatments/medications taken 0.8 1.4 2.8 0.3 1.7
Average weekly spirits intake 0.2 0.2 0.4 -0.1 -0.6
Sensitivity / hurt feelings 2.7 4.5 9.1 3.0 0.1
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 0.1 0.5
Hearing difficulty/problems: Yes 1.4 2.1 2.7 -1.2 -1.7
Relative age of first facial hair 0.6 1.3 2.5 0.1 -1.6
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.6 -0.4 -1.3
Ever used hormone-replacement therapy (HRT) 1.4 1.8 2.3 -1.1 -1.5
Ever had hysterectomy (womb removed) 0.4 0.5 1.0 0.2 1.0
Systolic blood pressure, automated reading 1.0 2.9 5.7 2.4 -0.2
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 1.6 -1.3 -1.0
Angina 0.0 0.0 0.0 -0.2 -0.1
Medication for hormone replacement therapy 1.2 1.3 1.7 -1.0 -1.3
Vitamin and mineral supplements 0.9 1.2 1.4 1.0 1.2
Supplements: Zinc 2.3 2.5 4.0 -2.0 -1.0
Medication: Co-codamol 1.3 1.5 3.0 0.0 -1.7
Medication: Metformin 0.4 0.5 0.7 -0.8 0.6
Diabetes (father) 1.1 1.4 1.8 -1.0 -1.3
Diabetes (mother) 0.9 1.2 2.1 -0.5 1.4
Severe depression (siblings) 2.9 3.3 5.8 -0.9 2.4
Pack years adult smoking proportion 0.8 1.2 2.2 -0.5 -1.5
Impedance of leg (right) 0.0 0.0 0.0 -0.0 0.1
Leg fat-free mass (left) 0.0 0.2 0.3 -0.5 -0.5
Trunk fat percentage 0.4 1.7 1.8 1.3 1.3
Hand grip strength (right) 0.2 0.4 0.8 0.1 -0.9
Townsend deprivation index at recruitment 0.8 1.1 1.6 1.2 0.8
Current tobacco smoking 1.3 2.1 2.4 1.6 -1.3
Average weekly fortified wine intake 0.6 0.7 1.4 0.2 -1.2
Maternal smoking around birth 3.3 4.8 8.2 -1.2 -2.9
Fed-up feelings 1.2 2.1 2.9 1.2 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 1.5 -1.2 -0.7
Relative age voice broke 1.2 1.8 1.8 -1.3 -1.4
Taking other prescription medications 0.4 0.6 1.1 0.2 1.1
Age when periods started (menarche) 0.4 1.0 1.5 -1.2 -0.6
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.3 0.4 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 1.3 0.7 -1.1
Tinnitus: Yes, but not now, but have in the past 1.4 1.4 2.9 -0.2 -1.7
Qualifications: CSEs or equivalent 1.0 1.4 2.2 -1.5 -0.7
Serious illness, injury or assault to yourself 0.9 1.1 2.2 0.0 1.5
High blood pressure 0.2 0.6 1.1 0.4 1.1
Hayfever, allergic rhinitis or eczema 0.8 1.7 1.7 -1.3 -1.3
Multivitamins +/- minerals 0.7 0.9 1.1 -1.0 -0.8
Stomach or abdominal pain in last month 0.5 0.6 1.1 -0.3 1.0
Supplements: Glucosamine 0.3 0.4 0.8 -0.2 0.9
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 2.0 -1.4 0.2
Medication: Atenolol 0.6 0.8 1.2 1.1 0.6
Medication: Levothyroxine sodium 0.6 1.0 1.9 -0.3 -1.4
Sitting height 0.1 0.6 1.3 -0.1 -1.1
Chronic bronchitis/emphysema (father) 0.3 0.4 0.5 -0.7 -0.6
High blood pressure (mother) 0.2 0.3 0.5 0.3 0.7
Body mass index (BMI) 0.0 0.0 0.0 0.0 -0.2
Impedance of leg (left) 0.0 0.1 0.2 0.4 0.1
Leg predicted mass (left) 0.1 0.3 0.3 -0.6 -0.5
Trunk fat mass 0.1 0.5 0.7 0.9 0.4
Waist circumference 0.1 0.2 0.4 -0.1 -0.6
Number of incorrect matches in round 1.5 2.4 3.2 1.8 1.3
Past tobacco smoking 0.0 0.1 0.1 -0.1 0.4
Alcohol usually taken with meals 0.6 0.9 1.8 1.3 0.0
Nervous feelings 0.7 1.4 2.2 1.5 0.8
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.3 -0.6 0.4
Hearing difficulty/problems with background noise 2.9 4.7 7.6 -2.8 -1.3
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 0.0 0.4
Had menopause 0.7 0.9 1.6 1.3 0.5
Had other major operations 0.6 0.8 0.9 1.0 -0.8
Forced vital capacity (FVC) 0.8 2.9 4.3 -2.1 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 0.9 -0.2 -0.9
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 1.9 -1.4 -1.1
Qualifications: None of the above 0.8 1.7 3.3 1.8 0.3
Financial difficulties in last 2 years 0.4 0.6 1.0 -1.0 0.3
Mouth/teeth dental problems 0.5 0.8 1.0 0.7 -1.0
Heart attack 1.5 2.0 3.3 1.8 0.8
Allergy 0.6 1.3 1.6 1.1 1.2
Pain all over the body in last month 1.0 1.1 2.0 -1.4 -0.5
Diabetes (self-reported) 0.2 0.3 0.4 -0.7 -0.4
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.9 -1.0 0.1
Medication: Ramipril 0.8 1.0 1.1 1.0 0.9
Medication: Simvastatin 0.1 0.1 0.1 0.4 0.2
Fluid intelligence score 1.7 3.4 6.9 0.1 -2.6
Illnesses of siblings 1.6 2.3 4.6 -0.1 -2.1
Neuroticism score 0.8 1.6 1.8 1.2 -1.3
Weight 0.0 0.2 0.2 -0.4 -0.5
Impedance of arm (right) 0.8 3.6 5.5 1.4 2.3
Arm fat percentage (right) 0.2 0.8 1.0 1.0 0.8
Trunk fat-free mass 0.4 2.2 3.0 -1.2 -1.7
Hip circumference 0.1 0.3 0.7 -0.2 0.8
Time employed in main current job 0.6 0.7 1.4 1.2 0.1
Alcohol intake versus 10 years previously 5.0 7.4 10.1 -3.2 -2.2
Father’s age at death 0.7 1.0 1.0 1.0 -1.0
Worrier / anxious feelings 0.3 0.6 1.0 0.4 1.0
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.7 2.0 -1.2 1.4
Falls in the last year 1.0 1.3 2.1 0.7 1.4
Hair/balding pattern: Pattern 3 0.1 0.2 0.4 -0.7 -0.0
Number of live births 0.1 0.1 0.2 -0.0 0.5
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 4.0 -2.0 -1.1
Pulse rate 1.6 2.7 3.2 -1.5 -1.8
Happiness 0.4 0.5 0.9 0.4 -0.9
Noisy workplace 0.0 0.1 0.1 0.3 -0.2
Qualifications: A levels/AS levels or equivalent 1.0 2.2 4.3 2.1 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.5 -0.7 -0.2
Mouth/teeth dental problems: Dentures 0.0 0.0 0.1 -0.3 0.1
Asthma 0.5 0.9 1.3 -1.2 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 0.7 0.9 -0.8
Medication: Cholesterol lowering 2.2 3.4 6.7 0.1 2.6
Depression (self-reported) 0.3 0.4 0.4 -0.6 0.7
Medication: Lansoprazole 0.7 0.8 1.4 1.2 -0.4
Prospective memory result 0.0 0.0 0.0 0.1 0.0
Lung cancer (father) 0.6 0.7 1.3 0.4 1.2
Illnesses of mother 2.6 3.2 5.9 0.6 -2.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.1 5.9 -2.4 -0.5
Pulse wave Arterial Stiffness index 0.7 0.9 1.3 0.7 1.1
Impedance of arm (left) 0.9 4.3 6.6 1.4 2.6
Arm fat mass (right) 0.0 0.1 0.1 0.3 -0.3
Trunk predicted mass 0.4 2.2 2.9 -1.2 -1.7
Standing height 0.1 0.7 0.9 -0.9 -0.7
Length of working week for main job 0.1 0.1 0.1 0.2 -0.3
Exposure to tobacco smoke at home 2.6 2.9 4.1 2.0 1.3
Breastfed as a baby 0.4 0.5 0.5 -0.7 -0.7
Tense / ‘highly strung’ 0.8 1.3 1.7 1.0 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 0.8 -0.4 -0.9
Hair/balding pattern: Pattern 4 0.5 1.1 2.1 0.4 -1.5
Birth weight of first child 0.8 1.5 2.1 1.0 -1.4
Peak expiratory flow (PEF) 0.6 1.5 2.7 -1.6 -0.5
Pulse wave reflection index 1.4 1.7 1.7 1.3 1.3
Ever highly irritable/argumentative for 2 days 2.5 3.0 4.0 -1.4 -2.0
Loud music exposure frequency 2.1 2.3 4.5 -2.1 0.4
Qualifications: O levels/GCSEs or equivalent 0.0 0.1 0.1 0.2 0.3
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 1.8 -0.6 1.3
Blood clot in the leg (DVT) 0.7 1.0 1.6 -1.3 -0.5
Medication: Paracetamol 0.2 0.4 0.7 0.8 0.3
Headache pain in last month 0.5 0.8 1.0 -1.0 -0.8
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.4 -0.5 -1.2
Glaucoma (self-reported) 1.1 1.3 1.9 0.8 1.4
Gout (self-reported) 0.2 0.2 0.4 0.2 0.6
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.2 -0.3 -0.4
Medication: Amlodipine 0.6 0.8 1.6 1.3 -0.2
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.2 0.4 1.1
Birth weight 0.8 1.8 1.9 1.4 -1.3
Chronic bronchitis/emphysema (mother) 2.2 2.5 3.3 -1.8 -1.3
High blood pressure (siblings) 2.3 3.3 5.8 0.9 2.4
Forced vital capacity (FVC), Best measure 0.6 2.3 4.4 -2.1 -0.4
Body fat percentage 0.2 0.9 1.3 1.1 0.7
Leg fat percentage (right) 0.1 0.2 0.4 0.2 -0.6
Arm fat-free mass (right) 0.4 2.0 3.1 -0.9 -1.8
Exposure to tobacco smoke outside home 2.3 3.1 5.3 2.3 0.9
Comparative body size at age 10 0.4 1.1 1.3 1.0 -1.1
Number of full brothers 0.5 0.6 1.2 -1.1 -0.2
Worry too long after embarrassment 0.3 0.5 0.7 -0.5 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.1 0.2 -0.3
Wheeze or whistling in the chest in last year 0.2 0.3 0.6 0.4 0.7
Number of children fathered 2.0 2.2 3.4 1.0 1.9
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 3.0 -0.3 1.7
Age at first live birth 0.1 0.2 0.2 -0.4 -0.5
Pulse wave peak to peak time 0.5 0.6 1.0 -0.5 -1.0
Health satisfaction 0.1 0.2 0.2 -0.3 -0.5
Shortness of breath walking on level ground 0.3 0.3 0.6 -0.2 -0.8
Qualifications: College or University degree 0.3 1.0 1.9 1.4 0.4
Eye problems/disorders: None of the above 0.7 0.8 1.4 1.2 0.6
Mouth/teeth dental problems: Loose teeth 1.1 1.3 2.5 0.4 1.6
Emphysema/chronic bronchitis 1.8 2.0 3.9 2.0 -0.3
Medication for pain relief, constipation, heartburn 0.7 1.1 1.2 -1.1 -1.0
Neck or shoulder pain in last month 1.6 2.3 3.6 -1.9 1.0
Medication: Blood pressure 0.6 1.1 1.4 1.2 0.9
Angina (self-reported) 0.0 0.1 0.1 -0.3 -0.2
Migraine (self-reported) 0.0 0.0 0.1 0.2 -0.0
Medication: Ibuprofen 0.7 0.8 1.2 0.6 -1.1
Medication: Allopurinol 0.5 0.7 1.3 0.3 1.1
Medication: Omeprazole 1.6 1.9 2.3 -1.5 1.2
Medication: Seretide 50 evohaler 0.3 0.3 0.5 0.7 0.4
Mean time to correctly identify matches 0.6 1.1 1.7 -0.8 1.3
Heart disease (mother) 3.1 3.8 7.2 -0.7 2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.0 0.0 0.1
Whole body fat mass 0.0 0.1 0.3 0.5 -0.1
Leg fat mass (right) 0.1 0.4 0.7 -0.2 -0.8
Arm predicted mass (right) 0.5 2.5 3.8 -1.1 -2.0
Pulse rate, automated reading 0.6 2.1 4.1 -0.1 -2.0
Alcohol intake frequency. 1.1 2.5 4.1 -2.0 -1.0
Comparative height size at age 10 0.0 0.3 0.4 -0.6 -0.3
Number of full sisters 0.6 0.7 1.5 -1.2 -0.0
Suffer from ‘nerves’ 0.7 1.0 1.9 0.3 1.4
Overall health rating 0.2 0.5 0.9 -0.9 -0.2
Chest pain or discomfort 1.7 2.5 4.0 -1.0 2.0
Had major operations 0.6 0.7 0.9 0.7 -1.0
Age at last live birth 0.4 0.5 1.0 0.1 -1.0
Family relationship satisfaction 0.1 0.1 0.2 -0.4 0.1
Leg pain on walking 0.5 0.6 1.1 -1.1 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.6 -0.8 -0.3
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.1 -0.1 -0.2
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.0 1.0 0.2
Medication: Aspirin 0.8 1.0 1.5 0.8 1.2
Supplements: Vitamin C 5.0 5.9 8.8 -3.0 -1.8
Knee pain experienced in last month 1.2 1.9 3.8 -0.1 2.0
Hypertension (Self-reported) 0.4 1.1 1.8 0.6 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.0 -0.2 0.2
Illnesses of father: Heart disease 0.3 0.5 0.9 -1.0 -0.1
Illnesses of siblings: Diabetes 0.5 0.6 1.0 0.5 1.0
Smoking status: Previous 0.1 0.2 0.3 0.3 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.1 0.8 1.0
Whole body fat-free mass 0.2 1.0 1.3 -0.9 -1.2
Leg fat-free mass (right) 0.0 0.1 0.1 -0.3 -0.2
Arm fat percentage (left) 0.2 0.7 1.0 1.0 0.7
Average weekly red wine intake 0.2 0.2 0.4 0.7 0.1
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.6 0.7 0.4
Mood swings 0.9 1.6 3.1 1.8 -0.2
Loneliness, isolation 2.2 3.0 3.4 -1.9 -1.6
Long-standing illness, disability or infirmity 1.3 2.0 3.3 -0.9 1.8
Ever had bowel cancer screening 0.7 0.8 1.1 -0.8 -1.0
Diabetes diagnosed by doctor 0.2 0.4 0.6 -0.8 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 0.6 -0.3 -0.8
Friendships satisfaction 0.4 0.4 0.9 -0.9 -0.1
Qualifications: nursing, teaching 1.5 2.3 4.5 -2.1 -0.4
Commuting to job workplace: Walk 0.8 0.8 1.1 0.8 1.0
Eye problems/disorders: Cataract 1.7 2.0 3.8 -1.9 -0.4
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 3.5 -1.9 0.1
Medication for cholesterol 0.4 0.6 1.1 -0.0 1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.5 -0.1 0.7
Back pain experienced in last month 0.1 0.1 0.2 0.1 0.5
Mineral and other dietary supplements 0.5 0.7 1.0 0.7 1.0
Breast cancer (self-reported) 1.3 1.5 2.6 1.6 0.7
Asthma (self-reported) 0.5 1.1 1.5 -1.2 -0.8
Osteoporosis (self-reported) 1.6 2.0 2.1 1.3 1.5
Osteoarthritis (self-reported) 1.5 1.9 3.3 0.7 1.8
Medication: Aspirin 0.3 0.4 0.6 0.4 0.8
Medication: Gliclazide 0.9 1.0 1.8 0.4 1.3
Illnesses of father: None of the above (group 1) 0.4 0.5 0.6 0.8 0.7
Smoking status: Current 1.3 2.0 2.8 1.7 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.3 6.6 -2.6 0.1
Whole body water mass 0.2 1.3 1.7 -1.0 -1.3
Leg predicted mass (right) 0.0 0.1 0.1 -0.3 -0.3
Arm fat mass (left) 0.0 0.1 0.1 0.3 -0.4
Number of self-reported non-cancer illnesses 0.9 1.5 2.1 0.9 1.5
Average weekly champagne plus white wine intake 0.6 0.8 1.3 1.1 0.5
Miserableness 0.2 0.4 0.7 0.3 -0.9
Guilty feelings 1.2 1.8 2.2 -1.1 -1.5
Wears glasses or contact lenses 0.5 0.6 1.0 -1.0 0.4
Ever taken oral contraceptive pill 0.5 0.6 0.9 -0.9 0.5
Hearing aid user 1.1 1.3 1.5 -1.0 -1.2
Mother’s age at death 0.2 0.2 0.3 0.4 0.5
Financial situation satisfaction 0.2 0.2 0.4 0.2 -0.7
Tinnitus: Yes, now most or all of the time 0.3 0.4 0.6 -0.8 0.4
Commuting to job workplace: Public transport 0.6 0.7 0.8 0.9 0.7
Eye problems/disorders: Glaucoma 0.4 0.4 0.8 0.9 0.4
Medication: Blood pressure 0.1 0.2 0.3 0.3 -0.5
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.1 -0.4 -0.2
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.0 -0.6 -1.0
High cholesterol (Self-reported) 0.1 0.2 0.3 0.5 0.3
Medication: Bendroflumethiazide 0.1 0.1 0.3 -0.5 -0.1
Medication: Paracetamol 0.0 0.0 0.0 0.1 0.1
Medication: Lisinopril 2.2 2.9 4.6 2.1 -1.1
Medication: Atorvastatin 0.9 1.1 2.1 -0.3 1.4
Illnesses of father: High blood pressure 0.1 0.1 0.2 -0.5 -0.1
Alcohol drinker status: Never 0.3 0.3 0.6 0.8 -0.1
Ever smoked 0.1 0.2 0.5 0.7 -0.2
Basal metabolic rate 0.2 0.9 1.2 -0.8 -1.1
Leg fat percentage (left) 0.1 0.3 0.4 0.4 -0.7
Arm fat-free mass (left) 0.4 2.1 2.9 -1.1 -1.7
Number of operations (self-reported) 1.6 2.4 4.8 2.2 -0.2
Average weekly beer plus cider intake 1.2 1.7 2.1 1.4 1.1
Irritability 3.0 5.0 5.2 2.3 -2.2
Risk taking 0.8 1.2 2.4 0.1 1.6
Ever had prostate specific antigen (PSA) test 1.3 1.5 2.4 1.5 0.8
Fractured/broken bones in last 5 years 2.3 3.0 4.9 1.1 2.2
Age started oral contraceptive pill 0.4 0.5 1.1 -0.1 1.0
Diastolic blood pressure, automated reading 0.8 2.5 3.2 1.8 -1.3
Ever depressed for a whole week 2.3 2.8 3.4 -1.8 -1.5
Unable to work because of sickness or disability 2.4 3.1 3.5 -1.9 1.6
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.4 0.0
Myopia 0.2 0.3 0.5 -0.2 0.7
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.5 -0.5 -0.7
Cholesterol lowering medication 1.4 2.1 4.0 -0.4 -2.0
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 1.7 -0.9 1.3
Pain experienced in last month 0.0 0.0 0.0 0.0 -0.2
Supplements: Calcium 0.1 0.2 0.2 -0.4 0.4
Basal cell carcinoma (self-reported) 0.0 0.0 0.0 0.2 -0.1
Heart attack/myocardial infarction (self-reported) 1.4 1.8 3.0 1.7 0.9
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 1.6 -1.3 -0.4
Heart disease (siblings) 0.0 0.0 0.1 0.2 0.1
Alcohol drinker status: Previous 1.0 1.1 2.2 -0.3 1.5
Pack years of smoking 0.4 0.6 1.1 -0.3 -1.1
Impedance of whole body 0.5 2.5 4.0 1.0 2.0
Leg fat mass (left) 0.1 0.4 0.9 0.0 -0.9
Arm predicted mass (left) 0.3 1.4 2.0 -0.9 -1.4