Hub : Genes

RP4-549L20.3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.123 0.063 0.00730 -0.001 NA -0.004 NA -0.001 3.9e-01 NA 0.55000 NA 3.9e-01
2 GTEx Brain Caudate basal ganglia 0.198 0.079 0.00270 -0.009 NA 0.003 NA -0.008 7.7e-01 NA 0.26000 NA 6.1e-01
3 GTEx Cells Transformed fibroblasts 0.114 0.046 0.00068 0.078 NA 0.056 NA 0.067 1.7e-06 NA 0.00005 NA 9.6e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.5 0.8 1.3 1.0 0.0 1.1
Bipolar Disorder or Schizophrenia 0.3 0.6 1.9 -0.2 0.0 -1.4
Depressed Affect (Nagel 2018) 0.3 0.7 1.2 -1.1 0.0 0.9
Depression (Nagel 2018) 0.1 0.2 0.4 -0.6 0.0 0.3
Intelligence (Savage-Jansen 2018) 0.6 1.7 3.1 1.4 0.0 -1.8
Neuroticism (Nagel 2018) 0.6 1.4 2.6 -1.6 0.0 1.3
Schizophrenia (2018) 1.3 2.7 7.1 -1.0 0.0 -2.7
Schizophrenia vs Biploar Disorder 1.2 1.5 4.5 -0.3 0.0 -2.1
Worry (Nagel 2018) 1.2 2.5 4.6 -2.2 0.0 1.7
Alzheimer’s Disease (in mother) 0.6 0.7 1.7 1.3 0.0 0.7
Alzheimer’s Disease (in father) 0.4 0.4 0.8 -0.9 0.0 -0.7
Alzheimer’s Disease (including proxy) 0.4 0.6 1.6 1.3 0.0 -0.3
Crohns Disease (2017) 0.7 1.5 4.0 -0.6 0.0 2.0
Irritable Bowel Disease (IBD) 2.2 5.2 13.5 -1.4 0.0 3.7
Ulcerative Colitis (UC) 2.1 4.0 9.9 -1.4 0.0 3.1
Major Depression (MDD) 0.0 0.0 0.0 0.1 0.0 -0.0
Reaction Time 3.5 6.7 19.4 -4.4 0.0 0.8
Verbal and Numeric Reasoning (VNR) 0.3 0.6 1.1 0.9 0.0 -1.1
Breast Cancer 0.2 0.6 1.7 1.3 0.0 -0.1
Ovarian Cancer 0.1 0.1 0.3 0.5 0.0 0.0
Prostate Cancer 1.2 1.6 3.6 -1.9 0.0 -1.1
Age at First Birth 0.8 1.1 3.2 1.8 0.0 0.4
Bipolar Disorder (2011) 0.4 0.4 1.1 -1.0 0.0 -0.0
Body Mass Index (BMI) (2010) 0.0 0.0 0.1 -0.3 0.0 -0.2
Coronary Artery Disease (CAD) 0.5 0.6 1.3 -0.8 0.0 -1.1
Crohns Disease (2012) 0.6 1.0 2.9 0.2 0.0 1.7
Mean Putamen Volume 0.4 0.5 0.9 -0.9 0.0 -0.7
Fasting Glucose 0.1 0.1 0.2 -0.4 0.0 0.3
HbA1C 0.1 0.1 0.2 -0.5 0.0 -0.0
HDL Cholesterol 0.4 0.7 2.1 0.2 0.0 -1.5
LDL Cholesterol 0.0 0.0 0.1 -0.3 0.0 0.2
Lupus 0.2 0.2 0.4 0.6 0.0 0.6
Neuroticism (2016) 0.5 0.7 1.3 -1.1 0.0 -0.8
Primary Biliary Cirrhosis 4.6 6.5 11.4 -3.4 0.0 2.9
Rheumatoid Arthritis 1.8 2.5 4.0 2.0 0.0 -1.9
Schizophrenia (2014) 0.9 1.9 5.8 0.2 0.0 -2.4
Triglycerides 0.1 0.1 0.2 0.5 0.0 -0.3
Type 2 Diabetes (T2D) (2012) 4.0 4.6 13.7 -3.7 0.0 0.3
Ulcerative Colitis 2.6 3.7 7.9 -1.8 0.0 2.8
Blood Eosinophil Count 3.8 29.6 66.3 4.8 0.0 -8.1
Blood Platelet Count 0.1 0.8 1.9 -0.7 0.0 1.4
Blood Red Count 0.6 5.5 12.6 -3.5 0.0 2.0
Blood White Count 3.7 27.5 53.4 7.3 0.0 -5.4
Heel T-Score 0.3 2.0 4.9 2.2 0.0 -1.1
BMI 0.5 3.0 6.9 -1.5 0.0 -2.6
Height 0.1 1.5 4.3 2.1 0.0 0.6
Waist Hip Ratio (WHR) 0.5 2.0 4.5 2.1 0.0 -1.3
Systolic Blood Pressure 0.3 1.6 4.0 0.9 0.0 2.0
Smoking Status 0.1 0.1 0.4 -0.3 0.0 -0.6
Allergy or Eczema 1.8 4.6 13.7 3.7 0.0 0.4
Cardiovascular Disease 0.1 0.2 0.5 0.1 0.0 0.7
Hypothyroidism (self reported) 0.9 2.1 3.8 -2.0 0.0 -1.6
Respiratory disease 0.6 1.2 3.3 0.6 0.0 -1.8
Type 2 Diabetes (T2D) (2018) 1.1 2.1 4.2 1.4 0.0 -2.0
Lung FEV1/FVC ratio 0.1 0.4 1.1 -0.2 0.0 -1.0
Lung FVC 0.2 1.1 3.2 -0.1 0.0 1.8
Neuroticism 0.4 1.0 1.7 -1.2 0.0 1.3
Chronotype (morning person) 0.5 1.2 3.1 -0.8 0.0 1.8
Hair Pigment 0.1 2.6 7.5 -2.7 0.0 0.4
Tanning 0.0 0.2 0.3 0.6 0.0 -0.4
Hand grip strength (left) 1.1 3.0 8.6 2.9 0.0 0.6
Number of treatments/medications taken 0.1 0.1 0.2 -0.5 0.0 0.2
Average weekly spirits intake 0.3 0.3 0.5 -0.7 0.0 0.7
Sensitivity / hurt feelings 0.6 1.1 3.0 -1.7 0.0 0.6
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.3 -0.5 0.0 0.5
Hearing difficulty/problems: Yes 0.3 0.5 1.0 -1.0 0.0 0.7
Relative age of first facial hair 0.0 0.1 0.2 -0.5 0.0 -0.0
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 4.4 -2.1 0.0 -0.2
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.7 -0.8 0.0 1.3
Ever had hysterectomy (womb removed) 0.4 0.5 1.1 1.0 0.0 0.6
Systolic blood pressure, automated reading 0.1 0.4 0.9 0.4 0.0 0.9
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.6 0.4 0.0 -1.3
Angina 0.1 0.1 0.2 -0.2 0.0 0.5
Medication for hormone replacement therapy 0.6 0.7 2.1 -1.4 0.0 -0.1
Vitamin and mineral supplements 0.8 1.1 3.0 0.6 0.0 -1.7
Supplements: Zinc 0.1 0.1 0.3 -0.5 0.0 -0.0
Medication: Co-codamol 0.5 0.6 1.5 -0.5 0.0 1.2
Medication: Metformin 0.5 0.7 1.6 1.3 0.0 -0.8
Diabetes (father) 0.0 0.1 0.1 0.2 0.0 0.4
Diabetes (mother) 0.1 0.1 0.1 0.3 0.0 0.3
Severe depression (siblings) 0.8 0.9 2.1 -0.7 0.0 -1.5
Pack years adult smoking proportion 0.5 0.7 1.5 -1.2 0.0 -0.8
Impedance of leg (right) 0.1 0.6 1.8 0.3 0.0 1.3
Leg fat-free mass (left) 0.2 0.9 2.8 0.1 0.0 -1.7
Trunk fat percentage 0.7 2.7 7.3 -2.7 0.0 -0.9
Hand grip strength (right) 0.7 1.9 5.2 2.3 0.0 0.6
Townsend deprivation index at recruitment 0.1 0.1 0.1 0.4 0.0 -0.3
Current tobacco smoking 0.1 0.1 0.4 0.1 0.0 -0.6
Average weekly fortified wine intake 0.0 0.0 0.1 -0.1 0.0 0.3
Maternal smoking around birth 0.5 0.7 1.3 -1.1 0.0 -0.9
Fed-up feelings 0.2 0.3 0.7 -0.4 0.0 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.1 -0.1 0.0 -0.3
Relative age voice broke 1.8 2.8 8.0 0.6 0.0 -2.8
Taking other prescription medications 0.8 1.3 3.5 -1.9 0.0 0.6
Age when periods started (menarche) 0.9 2.2 6.2 0.5 0.0 2.5
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.1 -0.1 0.0 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.6 0.8 0.0 -0.5
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.3 -0.5 0.0 0.1
Qualifications: CSEs or equivalent 1.6 2.1 6.2 0.2 0.0 -2.5
Serious illness, injury or assault to yourself 1.2 1.5 2.7 -1.6 0.0 1.3
High blood pressure 0.0 0.0 0.0 0.1 0.0 0.2
Hayfever, allergic rhinitis or eczema 1.2 2.6 7.3 2.7 0.0 0.6
Multivitamins +/- minerals 2.3 3.0 6.3 -1.6 0.0 2.5
Stomach or abdominal pain in last month 0.1 0.1 0.2 -0.3 0.0 -0.4
Supplements: Glucosamine 0.8 1.0 2.7 0.5 0.0 1.7
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.7 0.9 0.0 0.2
Medication: Atenolol 0.3 0.3 1.0 -0.0 0.0 -1.0
Medication: Levothyroxine sodium 0.2 0.3 1.0 -1.0 0.0 -0.1
Sitting height 0.1 0.8 2.0 1.4 0.0 -0.7
Chronic bronchitis/emphysema (father) 0.7 0.8 1.9 -1.4 0.0 -0.7
High blood pressure (mother) 0.7 0.9 2.1 -0.8 0.0 1.4
Body mass index (BMI) 0.5 1.9 3.2 -1.6 0.0 -1.8
Impedance of leg (left) 0.1 0.4 1.3 0.0 0.0 1.1
Leg predicted mass (left) 0.2 0.8 2.5 -0.0 0.0 -1.6
Trunk fat mass 0.4 1.8 4.1 -2.0 0.0 -1.2
Waist circumference 0.3 1.0 2.7 -0.5 0.0 -1.6
Number of incorrect matches in round 0.4 0.7 1.9 -0.3 0.0 -1.4
Past tobacco smoking 0.1 0.1 0.2 0.4 0.0 0.4
Alcohol usually taken with meals 0.7 1.1 3.0 -0.5 0.0 1.7
Nervous feelings 0.3 0.5 1.3 -1.1 0.0 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.6 -0.8 0.0 0.6
Hearing difficulty/problems with background noise 0.2 0.2 0.5 -0.4 0.0 -0.7
Hair/balding pattern: Pattern 2 0.2 0.3 0.7 -0.2 0.0 -0.9
Had menopause 0.3 0.3 0.5 0.7 0.0 0.7
Had other major operations 0.2 0.2 0.7 -0.8 0.0 -0.1
Forced vital capacity (FVC) 0.0 0.0 0.0 -0.2 0.0 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.9 0.6 0.0 -0.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.2 -0.5 0.0 1.1
Qualifications: None of the above 0.8 1.7 3.1 -1.8 0.0 1.5
Financial difficulties in last 2 years 1.7 2.3 6.3 0.8 0.0 -2.5
Mouth/teeth dental problems 2.8 4.3 12.1 3.5 0.0 -0.8
Heart attack 0.0 0.0 0.0 0.2 0.0 0.2
Allergy 1.0 2.4 7.0 -2.6 0.0 0.3
Pain all over the body in last month 0.6 0.7 1.6 -1.2 0.0 -0.6
Diabetes (self-reported) 0.3 0.4 0.8 0.9 0.0 -0.6
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.7 -0.1 0.0 0.8
Medication: Ramipril 0.3 0.4 0.8 -0.7 0.0 -0.9
Medication: Simvastatin 0.8 1.1 2.3 1.1 0.0 -1.5
Fluid intelligence score 0.5 1.1 2.8 0.7 0.0 -1.7
Illnesses of siblings 0.7 1.0 3.1 -0.2 0.0 -1.8
Neuroticism score 0.3 0.6 1.5 -1.2 0.0 0.4
Weight 0.3 1.3 3.2 -0.8 0.0 -1.8
Impedance of arm (right) 0.4 1.9 3.2 -1.5 0.0 1.8
Arm fat percentage (right) 0.6 2.4 5.4 -2.3 0.0 -1.4
Trunk fat-free mass 0.4 2.1 3.1 1.8 0.0 -1.8
Hip circumference 0.2 0.9 1.3 -1.1 0.0 -1.1
Time employed in main current job 1.5 1.8 5.2 -0.3 0.0 2.3
Alcohol intake versus 10 years previously 0.1 0.2 0.4 -0.4 0.0 -0.6
Father’s age at death 0.2 0.3 0.8 -0.4 0.0 -0.9
Worrier / anxious feelings 0.7 1.3 3.6 -1.9 0.0 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.8 -0.9 0.0 -0.3
Falls in the last year 1.2 1.7 3.2 -1.3 0.0 1.8
Hair/balding pattern: Pattern 3 0.3 0.4 1.1 1.1 0.0 -0.3
Number of live births 2.0 2.8 8.3 -2.9 0.0 -0.2
Forced expiratory volume in 1-second (FEV1) 0.0 0.0 0.0 -0.2 0.0 0.1
Pulse rate 0.5 0.9 2.4 -1.5 0.0 0.5
Happiness 1.0 1.2 3.4 1.8 0.0 -0.3
Noisy workplace 1.4 1.8 5.0 -2.2 0.0 0.6
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.3 0.6 0.0 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.1 0.2 0.0 -0.2
Mouth/teeth dental problems: Dentures 1.5 2.5 7.3 -2.7 0.0 -0.3
Asthma 0.5 1.0 3.0 -0.4 0.0 -1.7
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.3 1.5 0.0 -0.7
Medication: Cholesterol lowering 0.1 0.2 0.5 0.2 0.0 -0.7
Depression (self-reported) 0.3 0.4 0.9 0.6 0.0 -0.9
Medication: Lansoprazole 0.1 0.1 0.2 -0.4 0.0 0.5
Prospective memory result 2.0 2.4 5.0 -1.5 0.0 2.2
Lung cancer (father) 0.0 0.0 0.1 -0.4 0.0 -0.1
Illnesses of mother 0.1 0.2 0.3 -0.6 0.0 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.0 0.1 0.3 0.0 0.2
Pulse wave Arterial Stiffness index 2.2 2.5 7.1 2.7 0.0 -0.8
Impedance of arm (left) 0.3 1.4 3.0 -1.1 0.0 1.7
Arm fat mass (right) 0.6 2.4 4.2 -1.7 0.0 -2.0
Trunk predicted mass 0.3 1.8 2.9 1.6 0.0 -1.7
Standing height 0.1 0.9 2.6 1.6 0.0 -0.1
Length of working week for main job 1.0 1.1 3.2 1.8 0.0 0.4
Exposure to tobacco smoke at home 0.3 0.3 0.7 -0.4 0.0 -0.8
Breastfed as a baby 0.8 1.0 2.1 -0.9 0.0 1.5
Tense / ‘highly strung’ 1.5 2.4 6.2 -2.5 0.0 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.3 -0.3 0.0 0.5
Hair/balding pattern: Pattern 4 0.1 0.2 0.6 -0.8 0.0 -0.2
Birth weight of first child 0.2 0.4 0.7 -0.7 0.0 -0.8
Peak expiratory flow (PEF) 0.2 0.4 1.1 1.1 0.0 -0.4
Pulse wave reflection index 2.0 2.4 6.8 2.6 0.0 -0.7
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.4 0.1 0.0 -0.6
Loud music exposure frequency 0.1 0.1 0.2 -0.4 0.0 -0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.9 0.1 0.0 -0.9
Mouth/teeth dental problems: Bleeding gums 2.5 3.3 5.5 -2.3 0.0 2.1
Blood clot in the leg (DVT) 0.8 1.1 3.2 0.2 0.0 1.8
Medication: Paracetamol 0.1 0.2 0.7 0.0 0.0 -0.8
Headache pain in last month 0.3 0.5 1.4 1.2 0.0 -0.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.3 -1.2 0.0 1.0
Glaucoma (self-reported) 1.3 1.5 4.5 -2.1 0.0 0.4
Gout (self-reported) 0.6 0.8 2.3 -1.5 0.0 0.4
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 3.9 -2.0 0.0 -0.3
Medication: Amlodipine 0.7 0.9 2.4 0.6 0.0 1.5
Medication: Ventolin 100micrograms inhaler 1.3 1.6 2.5 -1.6 0.0 1.5
Birth weight 0.1 0.2 0.4 -0.4 0.0 -0.6
Chronic bronchitis/emphysema (mother) 0.0 0.1 0.1 0.4 0.0 -0.2
High blood pressure (siblings) 0.3 0.5 1.4 0.1 0.0 1.2
Forced vital capacity (FVC), Best measure 0.1 0.3 1.0 1.0 0.0 -0.3
Body fat percentage 0.5 2.1 5.2 -2.3 0.0 -1.0
Leg fat percentage (right) 0.2 0.8 2.0 -1.4 0.0 -0.7
Arm fat-free mass (right) 0.3 1.8 3.3 1.4 0.0 -1.8
Exposure to tobacco smoke outside home 0.3 0.4 1.2 -1.1 0.0 -0.2
Comparative body size at age 10 0.0 0.0 0.0 0.1 0.0 0.1
Number of full brothers 0.2 0.2 0.5 0.7 0.0 -0.1
Worry too long after embarrassment 0.9 1.5 3.8 -1.9 0.0 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.0 0.2 0.0 -0.1
Wheeze or whistling in the chest in last year 1.1 2.0 4.5 -2.1 0.0 -1.2
Number of children fathered 0.6 0.6 1.8 -1.3 0.0 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.3 0.5 0.0 -0.1
Age at first live birth 0.4 0.7 1.2 0.9 0.0 -1.1
Pulse wave peak to peak time 2.0 2.3 5.9 -2.4 0.0 1.1
Health satisfaction 0.2 0.2 0.3 -0.6 0.0 -0.6
Shortness of breath walking on level ground 1.0 1.1 2.8 -1.7 0.0 -0.8
Qualifications: College or University degree 0.6 2.0 5.3 2.3 0.0 -0.8
Eye problems/disorders: None of the above 0.9 1.0 2.0 1.4 0.0 -1.1
Mouth/teeth dental problems: Loose teeth 0.9 1.1 3.1 -1.8 0.0 -0.5
Emphysema/chronic bronchitis 0.2 0.2 0.5 0.4 0.0 -0.7
Medication for pain relief, constipation, heartburn 0.1 0.2 0.7 -0.8 0.0 0.3
Neck or shoulder pain in last month 0.3 0.5 1.2 -1.1 0.0 -0.5
Medication: Blood pressure 0.1 0.3 0.7 0.8 0.0 -0.3
Angina (self-reported) 0.0 0.0 0.0 -0.2 0.0 0.2
Migraine (self-reported) 0.1 0.1 0.4 0.6 0.0 0.1
Medication: Ibuprofen 0.2 0.3 0.7 0.9 0.0 0.2
Medication: Allopurinol 1.2 1.7 4.9 -2.2 0.0 -0.3
Medication: Omeprazole 1.0 1.2 2.1 -1.1 0.0 1.5
Medication: Seretide 50 evohaler 1.4 1.6 4.8 -2.2 0.0 0.4
Mean time to correctly identify matches 3.9 7.4 19.7 -4.4 0.0 1.6
Heart disease (mother) 0.4 0.4 1.3 1.1 0.0 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.1 -0.7 0.0 1.1
Whole body fat mass 0.4 1.7 3.0 -1.7 0.0 -1.4
Leg fat mass (right) 0.3 1.2 2.0 -1.2 0.0 -1.4
Arm predicted mass (right) 0.3 1.6 2.6 1.5 0.0 -1.6
Pulse rate, automated reading 0.2 0.8 1.7 -1.3 0.0 0.8
Alcohol intake frequency. 0.3 0.7 1.9 -1.4 0.0 0.4
Comparative height size at age 10 0.1 0.6 1.1 1.1 0.0 0.8
Number of full sisters 0.3 0.4 1.1 0.3 0.0 -1.0
Suffer from ‘nerves’ 0.8 1.2 2.2 -1.5 0.0 1.2
Overall health rating 0.7 1.6 4.3 -2.1 0.0 0.7
Chest pain or discomfort 2.2 3.2 9.3 -0.6 0.0 -3.0
Had major operations 0.2 0.2 0.6 -0.8 0.0 -0.4
Age at last live birth 0.2 0.4 0.8 -0.9 0.0 -0.5
Family relationship satisfaction 0.6 0.8 1.3 1.1 0.0 -1.0
Leg pain on walking 0.3 0.4 1.1 -1.1 0.0 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.6 0.8 0.0 -0.2
Commuting to job workplace: Car/motor vehicle 0.9 1.1 2.8 0.6 0.0 1.7
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.1 1.0 0.0 0.1
Medication: Aspirin 0.2 0.3 0.7 0.9 0.0 0.4
Supplements: Vitamin C 0.4 0.5 1.5 0.2 0.0 -1.2
Knee pain experienced in last month 0.9 1.4 4.0 -2.0 0.0 0.3
Hypertension (Self-reported) 0.1 0.2 0.5 0.1 0.0 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.5 -0.6 0.0 -0.7
Illnesses of father: Heart disease 0.0 0.0 0.0 0.0 0.0 0.1
Illnesses of siblings: Diabetes 0.4 0.5 0.9 0.9 0.0 0.7
Smoking status: Previous 0.0 0.1 0.2 -0.5 0.0 0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 3.1 1.8 0.0 -0.9
Whole body fat-free mass 0.2 1.4 3.1 1.0 0.0 -1.8
Leg fat-free mass (right) 0.2 1.0 3.1 0.1 0.0 -1.8
Arm fat percentage (left) 0.6 2.2 4.7 -2.2 0.0 -1.4
Average weekly red wine intake 0.7 1.1 1.9 1.4 0.0 -1.2
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 -0.3 0.0 -0.1
Mood swings 0.1 0.1 0.3 -0.2 0.0 -0.5
Loneliness, isolation 0.3 0.5 0.8 -0.8 0.0 -0.9
Long-standing illness, disability or infirmity 0.2 0.3 0.5 -0.7 0.0 0.6
Ever had bowel cancer screening 1.1 1.3 3.6 0.5 0.0 1.9
Diabetes diagnosed by doctor 0.6 1.0 1.8 1.0 0.0 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 3.8 -2.0 0.0 -1.0
Friendships satisfaction 2.7 3.4 9.6 3.1 0.0 -0.8
Qualifications: nursing, teaching 0.4 0.6 1.6 1.3 0.0 -0.5
Commuting to job workplace: Walk 2.1 2.3 5.9 -0.9 0.0 -2.4
Eye problems/disorders: Cataract 2.3 2.6 5.9 -1.4 0.0 2.4
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 3.7 -1.9 0.0 0.3
Medication for cholesterol 0.2 0.2 0.7 0.8 0.0 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 4.6 -2.1 0.0 1.1
Back pain experienced in last month 0.3 0.5 1.4 -1.2 0.0 0.2
Mineral and other dietary supplements 0.7 1.0 1.9 1.0 0.0 -1.4
Breast cancer (self-reported) 0.1 0.1 0.3 -0.1 0.0 0.5
Asthma (self-reported) 0.6 1.2 3.3 -0.4 0.0 -1.8
Osteoporosis (self-reported) 0.7 0.8 2.3 -0.4 0.0 1.5
Osteoarthritis (self-reported) 0.0 0.0 0.0 0.2 0.0 -0.2
Medication: Aspirin 0.1 0.1 0.2 0.4 0.0 -0.2
Medication: Gliclazide 0.7 0.8 1.7 1.3 0.0 -0.9
Illnesses of father: None of the above (group 1) 0.1 0.1 0.1 0.4 0.0 -0.2
Smoking status: Current 0.1 0.2 0.6 -0.1 0.0 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.3 0.2 0.0 0.5
Whole body water mass 0.3 1.5 3.5 1.0 0.0 -1.9
Leg predicted mass (right) 0.2 1.1 3.4 0.1 0.0 -1.9
Arm fat mass (left) 0.5 2.0 3.3 -1.6 0.0 -1.8
Number of self-reported non-cancer illnesses 0.2 0.4 0.6 -0.7 0.0 -0.8
Average weekly champagne plus white wine intake 0.5 0.6 1.5 -0.7 0.0 -1.2
Miserableness 0.1 0.2 0.5 -0.7 0.0 0.2
Guilty feelings 0.6 0.9 2.2 -0.7 0.0 -1.5
Wears glasses or contact lenses 0.1 0.1 0.1 0.3 0.0 0.4
Ever taken oral contraceptive pill 0.2 0.2 0.5 0.7 0.0 -0.4
Hearing aid user 0.8 0.9 2.4 -0.4 0.0 1.6
Mother’s age at death 1.1 1.4 2.8 -1.2 0.0 1.7
Financial situation satisfaction 0.2 0.2 0.6 0.8 0.0 0.0
Tinnitus: Yes, now most or all of the time 0.0 0.0 0.0 -0.1 0.0 0.1
Commuting to job workplace: Public transport 0.1 0.2 0.4 -0.2 0.0 -0.7
Eye problems/disorders: Glaucoma 1.1 1.3 3.7 -1.9 0.0 0.5
Medication: Blood pressure 0.0 0.1 0.2 0.4 0.0 0.3
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.2 -1.1 0.0 -0.3
Supplements: Fish oil (including cod liver oil) 0.6 0.7 2.2 -0.2 0.0 1.5
High cholesterol (Self-reported) 0.1 0.1 0.4 -0.6 0.0 0.1
Medication: Bendroflumethiazide 0.1 0.1 0.3 -0.3 0.0 -0.6
Medication: Paracetamol 0.0 0.1 0.2 -0.5 0.0 -0.1
Medication: Lisinopril 0.3 0.4 0.9 0.9 0.0 0.7
Medication: Atorvastatin 0.2 0.2 0.3 0.6 0.0 0.5
Illnesses of father: High blood pressure 0.3 0.3 1.0 1.0 0.0 -0.1
Alcohol drinker status: Never 0.6 0.7 1.4 -1.2 0.0 0.8
Ever smoked 0.1 0.2 0.6 0.8 0.0 -0.3
Basal metabolic rate 0.2 1.2 3.5 0.4 0.0 -1.9
Leg fat percentage (left) 0.3 1.1 2.8 -1.7 0.0 -0.8
Arm fat-free mass (left) 0.2 1.1 3.1 0.4 0.0 -1.8
Number of operations (self-reported) 0.1 0.1 0.3 -0.6 0.0 -0.1
Average weekly beer plus cider intake 0.1 0.1 0.3 -0.1 0.0 -0.6
Irritability 0.2 0.3 1.0 0.1 0.0 1.0
Risk taking 0.3 0.4 1.1 -1.0 0.0 -0.2
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.3 0.1 0.0 -0.5
Fractured/broken bones in last 5 years 1.2 1.6 3.6 -1.0 0.0 1.9
Age started oral contraceptive pill 0.2 0.3 0.5 0.6 0.0 0.7
Diastolic blood pressure, automated reading 0.0 0.1 0.2 0.4 0.0 0.4
Ever depressed for a whole week 0.5 0.6 1.3 0.7 0.0 -1.1
Unable to work because of sickness or disability 0.3 0.4 0.7 -0.7 0.0 0.9
Commuting to job workplace: Cycle 0.0 0.0 0.1 0.1 0.0 -0.4
Myopia 0.0 0.0 0.1 -0.3 0.0 -0.1
Vascular/heart problems diagnosed by doctor 0.1 0.1 0.4 -0.1 0.0 -0.7
Cholesterol lowering medication 0.0 0.0 0.0 -0.1 0.0 -0.0
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 2.6 -1.4 0.0 1.6
Pain experienced in last month 0.5 0.8 2.4 1.6 0.0 0.3
Supplements: Calcium 0.1 0.1 0.2 -0.5 0.0 0.2
Basal cell carcinoma (self-reported) 0.1 0.2 0.3 -0.5 0.0 -0.5
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.0 0.0 0.0 0.2
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 2.2 -0.2 0.0 1.5
Heart disease (siblings) 0.1 0.1 0.2 -0.4 0.0 0.3
Alcohol drinker status: Previous 0.1 0.1 0.1 -0.3 0.0 0.3
Pack years of smoking 0.5 0.7 2.0 -1.4 0.0 -0.4
Impedance of whole body 0.3 1.5 3.8 -0.8 0.0 1.9
Leg fat mass (left) 0.3 1.2 1.9 -1.2 0.0 -1.4
Arm predicted mass (left) 0.2 1.0 2.9 0.3 0.0 -1.7