Hub : Genes

RP4-756G23.5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1030 0.0640 4.0e-03 0.060 NA 0.023 NA 0.025 3.0e-04 NA 2.0e-02 NA 1.5e-02
2 GTEx Artery Tibial 0.0400 0.0223 5.4e-03 0.008 NA 0.001 NA 0.013 7.4e-02 NA 2.9e-01 NA 3.1e-02
3 GTEx Brain Cortex 0.0990 0.0530 8.9e-03 0.122 NA 0.019 NA 0.082 3.0e-04 NA 9.8e-02 NA 2.8e-03
4 GTEx Cells EBV-transformed lymphocytes 0.1170 0.0540 5.5e-03 0.105 NA 0.095 NA 0.085 2.8e-04 NA 5.3e-04 NA 9.8e-04
5 GTEx Cells Transformed fibroblasts 0.0660 0.0330 1.8e-03 0.056 NA 0.029 NA 0.025 5.3e-05 NA 2.7e-03 NA 5.3e-03
6 GTEx Esophagus Gastroesophageal Junction 0.1200 0.0550 1.9e-03 0.099 NA 0.031 NA 0.080 2.0e-04 NA 2.8e-02 NA 7.7e-04
7 GTEx Esophagus Mucosa 0.1000 0.0420 2.5e-06 0.094 NA 0.086 NA 0.087 8.0e-07 NA 2.4e-06 NA 1.9e-06
8 GTEx Heart Atrial Appendage 0.2730 0.1170 2.6e-03 0.064 NA 0.024 NA 0.040 8.2e-04 NA 3.0e-02 NA 7.0e-03
9 GTEx Heart Left Ventricle 0.0902 0.0406 2.3e-04 0.080 NA 0.046 NA 0.073 4.6e-05 NA 1.7e-03 NA 9.5e-05
10 GTEx Skin Sun Exposed Lower leg 0.0470 0.0250 3.7e-03 0.067 NA 0.044 NA 0.049 3.1e-06 NA 1.5e-04 NA 6.9e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 1.1 1.8 14.4 3.8 0.6 0.6 0.3 0.2 1.0 0.7 0.3 0.6 0.6
Bipolar Disorder or Schizophrenia 1.9 4.6 19.5 4.4 -0.6 1.8 1.3 1.5 2.1 2.2 1.8 1.7 1.7
Depressed Affect (Nagel 2018) 5.1 10.8 16.5 1.9 -4.1 3.0 2.7 3.2 3.7 3.7 4.0 3.0 3.0
Depression (Nagel 2018) 1.1 1.7 2.7 0.4 -1.3 1.3 1.2 1.3 1.5 1.3 1.6 1.3 1.3
Intelligence (Savage-Jansen 2018) 7.1 21.9 32.0 -1.2 4.0 -4.9 -4.8 -5.1 -5.0 -4.9 -5.7 -4.9 -4.9
Neuroticism (Nagel 2018) 8.5 20.0 31.1 4.3 -4.2 4.1 3.5 4.3 5.2 5.0 5.6 4.1 4.1
Schizophrenia (2018) 1.8 3.7 6.8 2.6 -1.2 1.8 1.4 1.7 1.9 2.3 2.3 1.8 1.8
Schizophrenia vs Biploar Disorder 0.5 0.6 2.5 -0.6 -1.2 0.5 0.5 0.7 0.2 0.6 1.6 0.5 0.5
Worry (Nagel 2018) 6.1 12.8 21.2 4.3 -2.5 3.1 2.6 3.1 4.6 3.8 4.6 3.1 3.1
Alzheimer’s Disease (in mother) 0.7 0.8 7.7 2.8 0.5 0.0 -0.1 -0.2 -0.0 0.4 -0.1 0.0 0.0
Alzheimer’s Disease (in father) 0.3 0.3 1.2 0.8 -1.1 0.1 -0.1 0.1 0.4 0.1 1.1 0.1 0.1
Alzheimer’s Disease (including proxy) 1.5 2.2 8.3 2.9 -1.2 1.2 0.9 1.0 1.0 1.4 1.7 1.2 1.2
Crohns Disease (2017) 1.2 2.6 5.7 2.4 -2.4 1.1 0.9 1.1 1.3 1.9 1.7 1.1 1.1
Irritable Bowel Disease (IBD) 0.4 1.0 6.7 2.6 -1.0 0.2 -0.1 0.2 0.4 0.8 1.0 0.2 0.2
Ulcerative Colitis (UC) 0.3 0.6 3.1 1.8 0.3 -0.7 -1.0 -0.8 -0.4 -0.3 -0.0 -0.7 -0.7
Major Depression (MDD) 0.6 0.7 3.2 1.8 -0.2 -0.6 -0.7 -0.6 0.6 0.0 1.3 -0.5 -0.5
Reaction Time 2.0 3.9 5.5 -2.0 1.8 -2.1 -2.1 -2.0 -1.7 -2.4 -1.1 -2.1 -2.1
Verbal and Numeric Reasoning (VNR) 8.2 19.6 25.1 -0.7 4.2 -4.7 -4.6 -4.9 -5.0 -4.6 -4.5 -4.7 -4.7
Breast Cancer 1.4 3.3 7.9 0.9 -2.8 1.9 2.0 1.7 1.9 1.8 -0.4 1.9 1.9
Ovarian Cancer 0.4 0.6 1.2 -1.1 0.1 -0.9 -0.9 -0.7 -0.5 -0.7 -0.0 -0.9 -0.9
Prostate Cancer 0.2 0.3 2.8 1.7 0.0 -0.2 -0.4 -0.2 -0.3 0.3 0.3 -0.2 -0.2
Age at First Birth 0.5 0.8 6.0 2.4 0.2 -0.2 -0.3 -0.4 -0.6 0.4 -0.8 -0.3 -0.3
Bipolar Disorder (2011) 0.9 0.9 1.8 1.4 -0.8 1.0 0.9 0.8 0.9 0.9 0.6 1.0 1.0
Body Mass Index (BMI) (2010) 4.9 6.7 8.7 1.5 -2.9 2.6 2.5 2.7 2.7 2.7 2.9 2.6 2.6
Coronary Artery Disease (CAD) 0.1 0.1 0.5 -0.7 0.1 0.2 0.3 0.2 -0.4 0.0 -0.1 0.2 0.2
Crohns Disease (2012) 0.7 1.1 5.9 2.4 -1.4 0.4 0.1 0.4 0.3 1.0 1.2 0.3 0.3
Mean Putamen Volume 0.3 0.3 0.6 0.8 -0.4 0.6 0.7 0.6 -0.3 0.4 -0.1 0.7 0.7
Fasting Glucose 1.1 1.3 3.8 -0.3 -1.9 1.2 1.1 1.3 0.7 1.3 0.5 1.2 1.2
HbA1C 1.3 1.4 2.2 0.3 -0.5 1.3 1.5 1.5 1.3 1.1 0.7 1.5 1.5
HDL Cholesterol 0.3 0.5 1.8 0.1 1.3 -0.6 -0.6 -0.8 -0.8 -0.8 -0.7 -0.5 -0.5
LDL Cholesterol 0.3 0.5 0.8 -0.7 0.2 0.9 0.9 0.8 0.3 0.8 0.6 0.9 0.9
Lupus 0.7 1.0 1.6 0.1 -1.0 1.1 1.0 1.0 1.3 0.9 1.2 1.1 1.1
Neuroticism (2016) 4.4 6.3 10.9 3.0 -1.9 2.3 2.1 2.3 3.3 2.7 2.7 2.2 2.2
Primary Biliary Cirrhosis 0.4 0.6 2.8 1.3 -1.7 0.4 0.2 0.3 0.4 0.9 0.6 0.4 0.4
Rheumatoid Arthritis 0.5 0.7 4.9 -2.2 0.8 -0.3 -0.2 -0.2 -0.8 -0.8 -0.5 -0.3 -0.3
Schizophrenia (2014) 2.1 4.6 7.9 2.8 -1.4 2.1 1.7 2.0 2.0 2.3 2.6 2.1 2.1
Triglycerides 0.3 0.4 2.5 0.1 -0.6 0.2 0.2 0.5 0.7 0.6 1.6 0.2 0.2
Type 2 Diabetes (T2D) (2012) 1.7 2.0 3.0 -1.7 -1.1 1.4 1.4 1.6 1.2 1.3 1.7 1.3 1.3
Ulcerative Colitis 0.1 0.2 0.6 0.8 -0.4 0.4 0.3 0.4 0.3 0.5 0.5 0.4 0.4
Blood Eosinophil Count 1.2 9.0 79.0 8.9 -1.9 0.5 -0.2 0.0 0.8 2.4 0.6 0.5 0.5
Blood Platelet Count 0.3 3.2 15.2 0.8 2.7 -1.0 -0.8 -1.4 -0.5 -1.7 -3.9 -1.0 -1.0
Blood Red Count 0.1 1.0 3.1 0.7 0.2 -0.9 -0.9 -1.1 -0.9 -1.1 -1.8 -0.9 -0.9
Blood White Count 0.0 0.1 0.5 -0.4 -0.7 0.0 0.1 0.0 0.5 -0.1 -0.3 0.0 0.0
Heel T-Score 2.3 18.4 32.3 4.3 3.4 -4.9 -5.7 -4.7 -3.9 -3.2 -0.9 -4.9 -4.9
BMI 3.4 19.9 25.1 -1.2 -5.0 4.9 5.0 4.9 4.6 4.5 3.3 4.8 4.8
Height 0.2 4.6 15.6 4.0 -3.9 1.6 1.3 1.2 0.6 2.0 0.9 1.6 1.6
Waist Hip Ratio (WHR) 0.3 1.5 3.2 -1.8 -1.1 -1.3 -1.3 -1.0 -1.4 -0.9 -0.5 -1.3 -1.3
Systolic Blood Pressure 1.7 8.5 12.0 -0.7 -1.8 3.4 3.5 3.5 2.6 3.0 2.7 3.4 3.4
Smoking Status 7.1 17.1 22.2 -2.9 4.2 -4.4 -4.2 -4.5 -3.7 -4.7 -3.5 -4.4 -4.4
Allergy or Eczema 2.7 7.2 24.1 4.9 -3.0 1.9 1.4 1.8 2.2 3.0 3.0 1.9 1.9
Cardiovascular Disease 3.4 11.3 14.2 0.9 -3.0 3.7 3.7 3.7 3.7 3.6 2.7 3.8 3.8
Hypothyroidism (self reported) 3.9 9.0 14.4 -0.9 3.0 -3.1 -3.0 -3.1 -3.8 -3.7 -2.3 -3.1 -3.1
Respiratory disease 0.6 1.4 7.8 1.6 -2.8 0.1 -0.2 0.4 0.7 1.0 1.5 0.1 0.1
Type 2 Diabetes (T2D) (2018) 5.5 10.3 12.5 0.5 -3.3 3.5 3.5 3.5 3.3 3.5 2.7 3.5 3.5
Lung FEV1/FVC ratio 6.7 34.1 51.3 -0.1 -4.8 6.6 6.7 6.4 7.2 6.5 3.2 6.6 6.6
Lung FVC 1.7 8.8 21.2 -0.2 2.8 -2.9 -2.7 -3.3 -2.4 -3.2 -4.6 -2.9 -2.9
Neuroticism 6.5 15.7 24.1 3.7 -3.7 3.7 3.3 3.8 4.9 4.5 4.3 3.7 3.7
Chronotype (morning person) 4.2 9.7 12.2 -1.5 -3.2 3.4 3.4 3.5 3.1 3.4 2.5 3.4 3.4
Hair Pigment 0.5 14.5 20.4 -3.5 3.3 -3.7 -3.4 -3.8 -4.0 -4.2 -4.5 -3.8 -3.8
Tanning 0.3 3.7 7.8 -2.8 2.0 -1.7 -1.4 -1.6 -2.1 -1.9 -1.9 -1.7 -1.7
Hand grip strength (left) 0.6 1.5 2.8 -1.2 -0.7 1.5 1.7 1.2 0.8 0.9 0.1 1.5 1.5
Number of treatments/medications taken 2.6 4.6 6.7 1.3 -2.6 2.1 1.9 2.2 2.5 2.2 2.3 2.1 2.1
Average weekly spirits intake 1.1 1.4 2.8 -1.7 0.8 -1.0 -0.9 -1.0 -1.3 -1.4 -1.4 -1.0 -1.0
Sensitivity / hurt feelings 3.1 5.2 8.3 1.9 -1.2 2.6 2.4 2.4 2.4 2.9 1.4 2.6 2.6
Frequency of depressed mood in last 2 weeks 0.6 0.9 1.9 1.4 -1.0 0.7 0.6 0.7 0.9 1.0 1.3 0.8 0.8
Hearing difficulty/problems: Yes 0.8 1.1 1.9 0.1 0.8 -1.1 -1.1 -1.2 -1.3 -1.4 -1.1 -1.1 -1.1
Relative age of first facial hair 0.5 1.0 3.1 1.2 -1.8 0.7 0.6 0.7 1.1 1.2 0.5 0.7 0.7
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.4 -0.2 0.5 -0.1 -0.2 0.1 -0.0 -0.0 0.6 -0.1 -0.1
Ever used hormone-replacement therapy (HRT) 1.1 1.4 2.0 -1.2 0.2 -1.3 -1.4 -1.2 -1.4 -1.2 -0.7 -1.3 -1.3
Ever had hysterectomy (womb removed) 0.4 0.5 0.7 -0.1 -0.7 0.7 0.6 0.7 0.8 0.8 0.9 0.7 0.7
Systolic blood pressure, automated reading 2.2 6.5 9.4 -1.6 -1.7 2.9 3.1 3.0 2.4 2.4 2.2 2.9 2.9
Eye problems/disorders: Diabetes related eye disease 3.9 4.2 5.3 2.1 -1.4 2.3 2.2 2.0 2.3 2.3 1.2 2.3 2.3
Angina 0.2 0.2 1.4 1.2 -0.9 0.2 0.0 -0.1 0.0 0.2 -0.4 0.2 0.2
Medication for hormone replacement therapy 0.3 0.3 1.4 -1.2 -0.2 0.3 0.3 0.5 0.2 0.0 0.9 0.3 0.3
Vitamin and mineral supplements 1.0 1.4 3.9 -1.4 1.4 -0.9 -0.7 -1.1 -0.8 -1.3 -2.0 -0.9 -0.9
Supplements: Zinc 2.5 2.7 3.8 -0.7 -1.4 1.9 2.0 1.9 1.8 1.6 1.2 1.9 1.9
Medication: Co-codamol 0.9 1.0 1.4 1.2 1.1 -1.0 -1.1 -1.1 -0.7 -1.1 -0.3 -1.1 -1.1
Medication: Metformin 1.6 2.3 3.2 -1.2 -0.7 1.7 1.8 1.7 1.3 1.5 1.4 1.7 1.7
Diabetes (father) 1.5 1.9 2.5 -0.6 -1.2 1.5 1.5 1.6 1.3 1.4 1.3 1.5 1.5
Diabetes (mother) 1.0 1.2 5.2 -2.3 1.1 -0.8 -0.6 -0.7 -1.2 -1.4 0.2 -0.8 -0.8
Severe depression (siblings) 0.3 0.4 0.8 0.9 -0.3 0.6 0.7 0.5 0.4 0.5 -0.8 0.6 0.6
Pack years adult smoking proportion 0.5 0.7 6.3 -2.5 -0.0 0.2 0.4 0.2 -0.2 -0.2 -0.7 0.2 0.2
Impedance of leg (right) 1.5 7.2 10.7 3.3 1.4 -3.1 -3.3 -2.9 -2.5 -2.1 -1.2 -3.1 -3.1
Leg fat-free mass (left) 2.9 15.5 19.8 1.2 -4.1 4.4 4.4 4.1 4.1 4.3 2.5 4.4 4.4
Trunk fat percentage 4.4 17.4 23.7 2.5 -4.8 4.2 3.9 4.2 4.6 4.9 3.9 4.2 4.2
Hand grip strength (right) 0.4 1.1 2.2 -1.1 -0.6 1.3 1.5 1.1 0.4 0.8 0.4 1.3 1.3
Townsend deprivation index at recruitment 0.6 0.8 3.4 -0.9 1.1 -0.7 -0.6 -0.8 -0.6 -0.6 -1.8 -0.7 -0.7
Current tobacco smoking 8.4 13.8 20.1 -2.9 3.5 -3.8 -3.5 -3.9 -3.6 -4.5 -3.7 -3.8 -3.8
Average weekly fortified wine intake 1.4 1.6 4.0 0.1 1.2 -1.4 -1.4 -1.4 -2.0 -1.1 -0.4 -1.4 -1.4
Maternal smoking around birth 3.4 4.9 8.2 -2.5 1.7 -2.3 -2.2 -2.2 -2.1 -2.9 -1.0 -2.3 -2.3
Fed-up feelings 3.2 5.9 11.5 2.2 -3.4 2.2 2.0 2.2 2.8 2.6 2.2 2.2 2.2
Frequency of unenthusiasm / disinterest in last 2 weeks 3.5 4.6 5.6 -0.2 -1.9 2.3 2.3 2.3 2.4 2.3 2.2 2.3 2.3
Relative age voice broke 0.2 0.4 1.1 0.9 -1.1 0.4 0.4 0.4 0.3 0.7 0.4 0.5 0.5
Taking other prescription medications 1.6 2.5 5.2 1.7 -1.4 1.3 1.0 1.5 2.0 1.7 2.3 1.3 1.3
Age when periods started (menarche) 2.2 5.3 11.8 3.4 2.9 -2.0 -2.3 -2.3 -2.3 -2.0 -0.4 -2.0 -2.0
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.6 -1.3 -0.6 0.5 0.6 0.6 0.6 0.6 0.4 0.5 0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 11.6 3.4 1.1 -1.7 -2.3 -1.8 -0.5 -0.8 0.3 -1.8 -1.8
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.1 -0.8 -1.0 1.0 1.0 0.8 0.9 0.9 0.5 1.0 1.0
Qualifications: CSEs or equivalent 1.3 1.7 2.5 -1.2 -1.0 1.4 1.6 1.5 0.9 1.3 0.8 1.4 1.4
Serious illness, injury or assault to yourself 0.2 0.3 1.1 1.1 -0.7 0.4 0.2 0.3 0.3 0.7 0.5 0.4 0.4
High blood pressure 1.2 3.4 4.6 0.9 -1.4 2.1 2.1 2.0 2.0 1.9 1.2 2.1 2.1
Hayfever, allergic rhinitis or eczema 1.9 4.1 15.0 3.9 -2.5 1.3 1.0 1.3 1.5 2.2 2.3 1.3 1.3
Multivitamins +/- minerals 2.0 2.5 4.1 1.0 -2.0 1.5 1.3 1.7 1.4 1.7 2.0 1.5 1.5
Stomach or abdominal pain in last month 0.4 0.5 1.1 0.9 0.6 -0.8 -1.0 -0.7 -0.0 -0.6 0.4 -0.8 -0.8
Supplements: Glucosamine 0.8 1.0 1.7 -0.7 1.2 -0.9 -1.0 -0.9 -1.3 -1.2 -0.9 -1.0 -1.0
Diverticular disease/diverticulitis (self-reported) 1.8 2.2 2.8 -0.9 1.3 -1.6 -1.6 -1.7 -1.0 -1.7 -1.4 -1.7 -1.7
Medication: Atenolol 0.7 0.9 3.8 -1.9 -0.7 0.9 1.0 1.0 0.5 0.3 0.3 0.9 0.9
Medication: Levothyroxine sodium 2.9 4.8 7.6 -1.1 2.6 -2.2 -2.3 -2.1 -2.8 -2.6 -1.1 -2.2 -2.2
Sitting height 0.2 1.4 6.2 2.5 -1.9 0.9 0.8 0.4 0.4 0.9 -0.6 0.8 0.8
Chronic bronchitis/emphysema (father) 0.7 0.8 1.8 -0.9 -1.0 -0.9 -0.9 -0.6 -0.1 -0.9 1.3 -0.9 -0.9
High blood pressure (mother) 0.2 0.3 1.1 -1.0 -0.5 0.4 0.5 0.3 0.6 0.1 -0.7 0.4 0.4
Body mass index (BMI) 3.7 15.9 20.4 -0.9 -3.7 4.4 4.5 4.4 4.3 4.2 3.1 4.4 4.4
Impedance of leg (left) 1.3 6.5 13.0 3.6 1.2 -2.8 -3.1 -2.7 -2.4 -1.9 -0.9 -2.8 -2.8
Leg predicted mass (left) 2.9 15.1 19.2 1.2 -4.1 4.4 4.3 4.0 4.0 4.3 2.4 4.4 4.4
Trunk fat mass 4.5 19.4 25.3 2.3 -4.8 4.6 4.4 4.5 4.8 5.0 3.9 4.6 4.6
Waist circumference 2.8 10.4 12.9 0.0 -3.6 3.5 3.4 3.4 3.4 3.6 2.7 3.5 3.5
Number of incorrect matches in round 4.4 7.3 10.8 1.8 -1.3 3.0 2.9 2.9 3.3 2.9 2.3 3.0 3.0
Past tobacco smoking 0.3 0.5 1.5 1.2 -0.5 0.6 0.7 0.5 0.1 0.3 -0.9 0.6 0.6
Alcohol usually taken with meals 0.2 0.3 1.4 1.2 -0.9 0.2 0.0 0.2 0.4 0.3 -0.2 0.2 0.2
Nervous feelings 1.3 2.5 14.3 3.8 -0.1 0.9 0.4 0.7 1.9 1.4 1.6 0.9 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 2.0 1.4 -0.4 0.0 -0.2 -0.0 1.0 0.5 0.7 0.0 0.0
Hearing difficulty/problems with background noise 1.0 1.6 2.2 -0.3 -0.7 1.5 1.4 1.5 1.2 1.2 1.2 1.5 1.5
Hair/balding pattern: Pattern 2 0.4 0.5 2.4 -0.4 -1.4 0.3 0.3 0.6 0.4 0.2 1.5 0.3 0.3
Had menopause 1.8 2.3 6.1 -0.7 1.1 -1.4 -1.3 -1.6 -1.6 -1.5 -2.5 -1.4 -1.4
Had other major operations 0.8 1.0 1.8 -0.3 -0.6 1.0 1.0 1.1 1.2 1.0 1.3 1.0 1.0
Forced vital capacity (FVC) 0.5 1.9 9.7 3.1 -0.3 -0.9 -0.9 -1.2 -0.7 -0.5 -1.9 -0.9 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 10.3 3.2 1.5 -1.5 -2.1 -1.7 -0.2 -0.7 0.0 -1.6 -1.6
Ever unenthusiastic/disinterested for a whole week 5.7 6.9 10.4 -0.2 -3.2 2.7 2.6 2.7 3.2 2.7 2.5 2.6 2.6
Qualifications: None of the above 0.3 0.6 3.0 -1.7 0.5 -0.6 -0.4 -0.2 0.1 -1.0 0.5 -0.5 -0.5
Financial difficulties in last 2 years 1.7 2.3 3.3 -0.1 1.0 -1.7 -1.6 -1.8 -1.6 -1.7 -1.5 -1.7 -1.7
Mouth/teeth dental problems 1.8 2.7 3.7 -1.5 -1.2 1.7 1.8 1.9 0.8 1.7 1.9 1.7 1.7
Heart attack 0.6 0.8 2.7 1.7 0.4 -0.8 -1.0 -0.9 -0.7 -0.6 -0.5 -0.8 -0.8
Allergy 1.7 3.8 12.0 -3.5 3.0 -1.0 -0.6 -1.1 -1.2 -2.1 -2.6 -1.0 -1.0
Pain all over the body in last month 0.2 0.2 1.3 1.1 -0.2 -0.1 -0.2 -0.1 0.6 -0.0 0.0 -0.1 -0.1
Diabetes (self-reported) 2.5 3.9 6.8 -0.9 -2.0 2.0 2.0 2.2 1.9 1.9 2.6 2.0 2.0
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 5.1 1.0 -2.1 0.7 0.6 1.0 1.0 1.1 2.3 0.7 0.7
Medication: Ramipril 0.8 1.0 1.8 0.9 -1.3 1.0 0.9 0.9 1.2 1.2 0.5 1.0 1.0
Medication: Simvastatin 0.8 1.1 7.0 -2.7 -0.4 0.7 0.7 0.7 1.1 0.2 0.4 0.7 0.7
Fluid intelligence score 4.1 8.4 11.2 -0.8 2.6 -3.1 -3.0 -3.3 -3.0 -3.1 -3.2 -3.1 -3.1
Illnesses of siblings 0.4 0.5 1.2 -0.8 0.8 -0.6 -0.7 -0.5 -1.1 -0.5 0.7 -0.6 -0.6
Neuroticism score 7.3 15.2 24.3 3.3 -3.5 3.8 3.4 3.7 4.9 4.5 3.9 3.8 3.8
Weight 3.8 18.7 23.2 1.5 -4.6 4.8 4.7 4.5 4.6 4.8 3.2 4.7 4.7
Impedance of arm (right) 0.7 3.1 18.1 4.2 -0.9 -1.5 -1.9 -1.2 -0.5 -0.0 0.5 -1.4 -1.4
Arm fat percentage (right) 4.3 16.8 21.8 1.0 -4.7 4.3 4.2 4.3 4.7 4.6 3.5 4.3 4.3
Trunk fat-free mass 1.1 6.6 9.8 0.6 -2.6 3.1 3.1 2.6 2.5 2.6 1.1 3.0 3.0
Hip circumference 3.9 16.9 21.3 1.8 -3.5 4.4 4.3 4.2 4.6 4.6 4.0 4.4 4.4
Time employed in main current job 1.6 1.8 2.6 1.2 0.6 1.6 1.6 1.3 1.4 1.6 0.8 1.6 1.6
Alcohol intake versus 10 years previously 1.2 1.8 5.7 0.5 -2.4 1.2 1.3 1.3 1.3 1.2 1.2 1.2 1.2
Father’s age at death 1.3 1.8 2.4 0.4 1.3 -1.4 -1.5 -1.4 -1.5 -1.3 -1.3 -1.4 -1.4
Worrier / anxious feelings 6.0 11.2 19.5 2.8 -2.2 3.2 2.8 3.4 3.8 3.9 4.4 3.2 3.2
Frequency of tiredness / lethargy in last 2 weeks 6.2 10.1 15.7 2.5 -3.6 3.0 2.8 3.0 4.0 3.6 3.0 3.0 3.0
Falls in the last year 0.4 0.6 1.2 0.4 -0.3 0.8 0.7 0.8 0.9 0.7 1.1 0.8 0.8
Hair/balding pattern: Pattern 3 1.0 1.6 3.2 0.4 -1.2 1.2 1.2 1.1 1.7 1.0 1.8 1.2 1.2
Number of live births 0.6 0.9 2.7 -1.6 0.8 -0.8 -0.8 -0.7 -0.4 -0.9 -1.2 -0.8 -0.8
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 8.2 2.9 -1.7 1.0 1.0 0.6 1.1 1.3 -0.6 1.0 1.0
Pulse rate 0.4 0.6 5.1 2.3 -0.4 0.2 0.2 0.1 0.7 0.3 0.1 0.2 0.2
Happiness 3.2 3.9 5.8 1.2 -2.4 2.1 1.9 1.8 2.1 2.2 1.6 2.1 2.1
Noisy workplace 0.2 0.2 0.8 -0.4 -0.1 0.5 0.6 0.5 0.2 0.3 0.9 0.5 0.5
Qualifications: A levels/AS levels or equivalent 1.9 4.3 6.8 2.0 2.6 -1.9 -1.8 -2.3 -2.1 -1.7 -2.3 -1.9 -1.9
Serious illness, injury or assault of a close relative in last 2 years 5.0 5.7 8.6 -0.9 2.2 -2.6 -2.6 -2.6 -2.9 -2.9 -0.6 -2.6 -2.6
Mouth/teeth dental problems: Dentures 4.3 7.2 10.4 -0.8 1.6 -2.9 -2.9 -2.9 -2.9 -3.2 -2.8 -2.9 -2.9
Asthma 0.4 0.9 4.0 1.6 -2.0 -0.1 -0.4 0.1 0.4 0.8 1.2 -0.1 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 2.5 1.6 -0.2 -0.7 -0.8 -0.8 -0.6 -0.6 -0.6 -0.7 -0.7
Medication: Cholesterol lowering 0.8 1.2 1.6 -1.2 -0.4 1.2 1.2 1.2 1.3 0.9 0.7 1.2 1.2
Depression (self-reported) 0.6 0.7 3.7 1.9 -0.5 0.5 0.3 0.3 1.2 0.8 0.6 0.5 0.5
Medication: Lansoprazole 0.7 0.8 1.3 0.1 -0.7 0.9 0.7 1.0 1.0 1.1 1.1 0.9 0.9
Prospective memory result 0.5 0.6 1.4 1.2 -0.5 0.7 0.8 0.7 0.9 0.7 0.2 0.7 0.7
Lung cancer (father) 1.8 2.1 3.7 -0.3 1.3 -1.5 -1.5 -1.3 -1.9 -1.9 -0.4 -1.5 -1.5
Illnesses of mother 1.6 1.9 3.7 -0.3 1.9 -1.4 -1.4 -1.3 -1.9 -1.4 -0.9 -1.4 -1.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.2 10.9 3.3 -2.3 1.4 1.4 1.1 1.6 1.7 -0.2 1.5 1.5
Pulse wave Arterial Stiffness index 3.1 3.6 4.7 0.5 -2.1 2.1 2.2 2.1 1.7 1.8 1.6 2.1 2.1
Impedance of arm (left) 0.6 2.5 15.8 4.0 -1.9 -0.9 -1.3 -0.6 0.1 0.6 1.0 -0.9 -0.9
Arm fat mass (right) 4.7 19.4 24.0 1.1 -4.7 4.7 4.7 4.6 4.8 4.9 3.5 4.7 4.7
Trunk predicted mass 1.2 6.8 10.1 0.7 -2.7 3.1 3.2 2.7 2.5 2.6 1.2 3.1 3.1
Standing height 0.5 4.5 25.7 5.1 -2.6 1.3 1.0 0.8 1.1 2.0 0.6 1.3 1.3
Length of working week for main job 0.7 0.7 1.5 -1.2 -1.0 0.8 0.7 1.0 0.4 0.7 1.0 0.8 0.8
Exposure to tobacco smoke at home 0.8 0.9 1.9 1.4 1.4 -0.8 -0.9 -1.0 -0.8 -0.8 -0.4 -0.8 -0.8
Breastfed as a baby 0.3 0.4 1.2 1.1 -0.7 -0.5 -0.6 -0.5 -0.7 -0.2 0.3 -0.5 -0.5
Tense / ‘highly strung’ 8.2 13.6 21.5 3.3 -3.8 3.5 3.2 3.5 4.6 4.1 3.6 3.5 3.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.8 5.6 2.1 -1.8 1.4 1.1 1.4 1.9 1.6 2.4 1.3 1.3
Hair/balding pattern: Pattern 4 1.9 4.6 11.5 -2.0 3.4 -1.9 -1.7 -2.0 -2.2 -2.1 -1.9 -1.9 -1.9
Birth weight of first child 1.5 2.7 3.6 1.4 -1.9 1.8 1.7 1.6 1.9 1.7 0.6 1.8 1.8
Peak expiratory flow (PEF) 1.4 3.1 4.6 0.8 -1.9 2.0 2.1 1.8 1.7 2.1 0.4 2.0 2.0
Pulse wave reflection index 1.7 2.1 3.4 0.1 -1.2 1.7 1.8 1.7 1.2 1.4 0.8 1.7 1.7
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.9 0.1 -1.4 0.3 0.2 0.3 0.9 0.5 0.9 0.2 0.2
Loud music exposure frequency 4.1 4.4 6.6 1.5 1.8 -2.2 -2.2 -2.4 -2.1 -1.8 -2.6 -2.2 -2.2
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.2 0.9 0.4 -0.8 -0.8 -0.9 -1.5 -0.7 -0.4 -0.8 -0.8
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 4.1 1.8 -1.1 1.4 1.4 1.3 2.0 1.4 1.0 1.4 1.4
Blood clot in the leg (DVT) 1.2 1.6 2.5 -0.3 -0.7 1.5 1.6 1.4 1.6 1.3 0.2 1.5 1.5
Medication: Paracetamol 1.5 2.4 7.5 2.7 -1.3 1.4 1.3 1.2 1.7 1.5 1.1 1.4 1.4
Headache pain in last month 2.4 4.1 8.8 0.9 -3.0 2.1 2.0 2.2 1.7 2.0 1.5 2.1 2.1
Medication for cholesterol, blood pressure or diabetes 2.5 4.1 5.9 0.4 1.0 -2.4 -2.4 -2.3 -2.4 -2.0 -1.5 -2.4 -2.4
Glaucoma (self-reported) 0.4 0.5 2.6 1.6 0.9 -0.2 -0.5 -0.2 0.0 0.4 0.7 -0.2 -0.2
Gout (self-reported) 0.6 0.9 3.4 1.8 -0.2 -0.9 -1.1 -0.8 -0.6 -0.6 0.2 -0.9 -0.9
Hypothyroidism/myxoedema (self-reported) 2.1 4.1 7.4 -1.0 2.0 -2.1 -2.0 -2.0 -2.7 -2.6 -1.2 -2.1 -2.1
Medication: Amlodipine 0.3 0.4 0.8 -0.5 0.0 0.8 0.9 0.7 0.3 0.3 -0.2 0.8 0.8
Medication: Ventolin 100micrograms inhaler 0.8 1.0 7.8 2.8 -1.2 -0.0 -0.3 0.1 0.1 0.7 0.8 -0.0 -0.0
Birth weight 0.1 0.2 1.5 1.2 -0.4 0.3 0.2 0.0 0.5 0.2 -0.3 0.3 0.3
Chronic bronchitis/emphysema (mother) 0.9 1.1 3.7 -0.1 -1.9 0.9 0.8 1.0 1.2 0.8 0.8 0.9 0.9
High blood pressure (siblings) 0.2 0.3 1.6 1.2 0.3 0.3 0.2 0.1 0.7 0.2 -0.6 0.3 0.3
Forced vital capacity (FVC), Best measure 0.3 1.2 7.1 2.7 -0.7 -0.5 -0.5 -0.8 -0.4 -0.3 -1.7 -0.5 -0.5
Body fat percentage 4.0 15.8 20.9 1.8 -4.4 4.1 3.9 4.1 4.5 4.6 3.6 4.1 4.1
Leg fat percentage (right) 2.4 8.8 12.6 0.3 -2.9 3.1 3.1 3.2 3.5 3.2 2.8 3.1 3.1
Arm fat-free mass (right) 1.6 8.0 11.6 0.6 -2.8 3.3 3.4 2.9 2.7 2.9 1.5 3.3 3.3
Exposure to tobacco smoke outside home 5.4 7.2 9.6 0.2 2.3 -3.0 -3.0 -3.1 -2.8 -3.0 -2.4 -2.9 -2.9
Comparative body size at age 10 0.9 2.6 5.6 -2.4 0.8 1.9 2.1 1.6 1.2 1.0 0.1 1.8 1.8
Number of full brothers 3.1 3.8 5.2 -0.3 1.7 -2.2 -2.1 -2.3 -1.7 -2.1 -2.0 -2.2 -2.2
Worry too long after embarrassment 1.8 3.0 6.5 0.9 -1.1 1.7 1.4 1.8 2.0 2.0 2.5 1.6 1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 4.0 5.2 7.5 2.7 -2.5 2.1 1.8 2.0 2.7 2.5 2.0 2.1 2.1
Wheeze or whistling in the chest in last year 0.2 0.3 1.2 1.0 -1.1 -0.2 -0.4 -0.1 0.1 0.4 0.7 -0.2 -0.2
Number of children fathered 0.9 1.0 7.7 -2.8 0.1 0.4 0.6 0.6 0.8 -0.2 0.3 0.4 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 1.1 1.1 1.1 -0.2 -0.2 -0.4 -0.2 -0.2 0.2 -0.2 -0.2
Age at first live birth 1.4 2.4 6.9 2.6 -0.7 1.5 1.3 1.2 1.4 1.9 0.9 1.5 1.5
Pulse wave peak to peak time 2.0 2.4 3.4 -0.2 1.8 -1.7 -1.8 -1.7 -1.3 -1.4 -1.2 -1.8 -1.8
Health satisfaction 1.4 1.8 3.0 -0.1 -1.7 1.3 1.2 1.4 1.5 1.2 1.6 1.3 1.3
Shortness of breath walking on level ground 0.2 0.2 1.9 1.4 -0.4 0.0 -0.0 -0.1 0.2 0.2 -0.0 0.0 0.0
Qualifications: College or University degree 0.4 1.2 5.6 2.4 0.9 -0.8 -0.9 -1.0 -1.1 -0.5 -0.8 -0.7 -0.7
Eye problems/disorders: None of the above 4.6 5.4 8.4 -0.8 1.9 -2.6 -2.6 -2.4 -2.9 -2.6 -1.3 -2.6 -2.6
Mouth/teeth dental problems: Loose teeth 1.7 2.0 3.9 -1.3 2.0 -1.2 -1.0 -1.3 -1.3 -1.7 -1.7 -1.2 -1.2
Emphysema/chronic bronchitis 0.5 0.5 0.9 -0.8 0.3 -0.8 -1.0 -0.5 -0.2 -0.7 1.0 -0.8 -0.8
Medication for pain relief, constipation, heartburn 1.1 1.9 6.8 -2.6 1.4 -1.1 -0.8 -1.0 -1.7 -1.3 -1.1 -1.1 -1.1
Neck or shoulder pain in last month 0.8 1.1 4.7 0.6 -1.2 0.7 0.4 0.8 1.1 0.8 2.2 0.7 0.7
Medication: Blood pressure 1.2 2.2 3.1 0.8 -0.5 1.7 1.8 1.6 1.7 1.6 0.8 1.7 1.7
Angina (self-reported) 0.1 0.2 1.0 1.0 -0.5 -0.1 -0.2 -0.3 -0.2 -0.1 -0.6 -0.1 -0.1
Migraine (self-reported) 4.8 6.0 7.3 0.7 -2.4 2.7 2.6 2.6 2.6 2.6 2.1 2.7 2.7
Medication: Ibuprofen 1.9 2.3 4.3 2.1 0.2 -1.6 -1.8 -1.7 -1.3 -1.3 -1.3 -1.6 -1.6
Medication: Allopurinol 0.5 0.7 3.0 1.5 -0.9 -0.1 -0.4 0.1 0.0 0.3 1.7 -0.2 -0.2
Medication: Omeprazole 1.5 1.7 3.3 1.2 0.8 -1.6 -1.8 -1.5 -1.0 -1.1 -0.2 -1.6 -1.6
Medication: Seretide 50 evohaler 0.4 0.5 1.4 -0.5 -0.6 0.6 0.5 0.9 0.6 0.7 1.2 0.6 0.6
Mean time to correctly identify matches 3.6 6.9 9.5 -3.0 2.9 -2.6 -2.6 -2.5 -2.4 -3.1 -1.6 -2.6 -2.6
Heart disease (mother) 0.4 0.4 1.1 -0.3 -1.1 0.6 0.6 0.4 0.9 0.6 -0.7 0.6 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.4 -1.2 1.2 -0.5 -0.6 -0.2 -0.8 -0.2 1.1 -0.5 -0.5
Whole body fat mass 4.1 17.3 22.4 1.7 -4.4 4.4 4.3 4.3 4.6 4.7 3.5 4.4 4.4
Leg fat mass (right) 3.3 13.0 16.0 0.6 -3.5 4.0 3.9 3.8 4.0 4.0 3.0 3.9 3.9
Arm predicted mass (right) 1.6 8.1 11.9 0.5 -2.8 3.4 3.4 2.9 2.8 2.9 1.6 3.3 3.3
Pulse rate, automated reading 0.5 1.6 10.3 3.2 -0.3 1.0 0.9 0.6 1.1 0.9 -0.2 1.0 1.0
Alcohol intake frequency. 4.1 9.4 14.0 2.3 -3.4 3.1 2.9 3.1 3.7 3.4 2.3 3.1 3.1
Comparative height size at age 10 0.2 1.2 3.4 0.8 -1.8 1.1 1.0 1.1 0.9 1.1 0.5 1.0 1.0
Number of full sisters 8.5 10.4 13.6 -1.3 3.3 -3.5 -3.5 -3.4 -3.6 -3.7 -1.9 -3.5 -3.5
Suffer from ‘nerves’ 2.1 3.3 7.1 1.0 -1.3 1.7 1.5 1.7 2.5 1.8 2.7 1.7 1.7
Overall health rating 2.1 4.5 6.5 0.2 -2.3 2.1 2.0 2.3 2.6 2.3 2.4 2.1 2.1
Chest pain or discomfort 1.3 1.9 2.6 1.5 -1.6 1.4 1.2 1.2 1.4 1.6 1.1 1.4 1.4
Had major operations 0.8 0.9 2.9 -1.7 0.9 -0.9 -0.9 -0.6 -0.8 -1.0 -0.2 -0.9 -0.9
Age at last live birth 2.9 4.2 6.2 2.4 -1.4 2.2 2.1 1.9 2.3 2.5 0.5 2.2 2.2
Family relationship satisfaction 2.3 2.8 4.3 0.9 -2.1 1.8 1.6 1.5 1.8 2.0 1.1 1.8 1.8
Leg pain on walking 0.3 0.4 1.1 -0.3 0.2 -0.8 -0.8 -0.7 -0.3 -1.0 -0.1 -0.8 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.7 -0.1 0.8 -0.3 -0.3 -0.2 -0.7 -0.5 0.5 -0.3 -0.3
Commuting to job workplace: Car/motor vehicle 0.4 0.5 3.1 -1.0 -0.6 0.2 0.2 0.6 0.0 0.2 1.8 0.3 0.3
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 2.4 -0.1 -0.2 1.4 1.5 1.5 1.6 1.5 0.7 1.5 1.5
Medication: Aspirin 0.4 0.5 0.9 -0.4 0.9 -0.7 -0.7 -0.8 -0.2 -0.8 -0.8 -0.7 -0.7
Supplements: Vitamin C 0.1 0.1 0.5 -0.4 -0.1 -0.0 -0.0 0.1 -0.5 -0.1 0.7 -0.1 -0.1
Knee pain experienced in last month 0.3 0.5 1.9 -0.8 -1.4 0.2 0.2 0.4 1.0 0.0 0.9 0.2 0.2
Hypertension (Self-reported) 1.1 3.1 3.9 1.2 -1.4 2.0 1.9 1.8 1.9 1.9 1.2 2.0 2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.7 -0.6 -0.3 -0.4 -0.4 -0.1 -0.1 -0.4 0.8 -0.3 -0.3
Illnesses of father: Heart disease 1.3 1.7 2.5 -0.3 -0.8 1.6 1.6 1.5 1.4 1.5 0.4 1.6 1.6
Illnesses of siblings: Diabetes 2.6 3.2 4.5 0.1 -1.8 2.0 2.1 2.0 2.1 1.6 0.9 2.1 2.1
Smoking status: Previous 1.3 1.9 6.3 -1.1 -1.0 1.1 1.0 1.4 1.5 1.4 2.5 1.1 1.1
Forced expiratory volume in 1-second (FEV1), predicted 2.0 4.1 8.8 2.1 -3.0 2.0 2.0 1.7 1.5 2.2 1.1 2.0 2.0
Whole body fat-free mass 1.9 10.8 14.9 0.9 -3.3 3.8 3.9 3.4 3.3 3.5 1.8 3.8 3.8
Leg fat-free mass (right) 2.9 15.5 19.9 1.3 -4.0 4.5 4.4 4.1 4.0 4.3 2.5 4.4 4.4
Arm fat percentage (left) 4.8 19.0 26.0 0.8 -5.1 4.5 4.4 4.6 4.9 4.9 3.8 4.5 4.5
Average weekly red wine intake 2.0 3.0 5.7 -1.0 1.6 -1.6 -1.6 -1.7 -2.0 -2.0 -2.4 -1.6 -1.6
Handedness (chirality/laterality): Left-handed 0.4 0.5 4.3 2.1 0.1 0.2 0.3 0.1 0.4 0.1 -0.6 0.2 0.2
Mood swings 8.1 14.7 21.5 4.6 -3.5 3.5 3.1 3.4 4.4 4.4 4.1 3.5 3.5
Loneliness, isolation 0.4 0.5 2.6 0.5 -1.6 0.4 0.4 0.3 1.2 0.7 -0.0 0.4 0.4
Long-standing illness, disability or infirmity 2.4 3.7 5.6 0.5 -1.6 2.0 1.8 2.1 2.1 2.0 2.4 2.0 2.0
Ever had bowel cancer screening 0.8 0.9 2.2 0.9 -0.0 1.0 0.9 1.0 1.5 1.0 0.7 1.0 1.0
Diabetes diagnosed by doctor 4.3 7.1 8.9 -0.4 -2.3 2.8 2.8 3.0 2.8 2.8 2.9 2.8 2.8
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 2.1 -1.4 -0.1 -0.2 -0.2 -0.2 0.5 -0.1 -0.6 -0.2 -0.2
Friendships satisfaction 0.8 1.0 3.6 -1.3 -0.8 0.7 0.6 0.9 0.6 0.8 1.9 0.8 0.8
Qualifications: nursing, teaching 0.5 0.8 2.8 1.1 -1.7 0.6 0.6 0.3 1.0 1.0 -0.5 0.6 0.6
Commuting to job workplace: Walk 0.8 0.9 1.3 1.1 0.9 -0.9 -1.0 -1.1 -0.9 -0.8 -0.7 -0.9 -0.9
Eye problems/disorders: Cataract 5.2 6.0 8.2 0.6 -1.8 2.7 2.8 2.6 2.9 2.7 1.8 2.8 2.8
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 4.8 2.2 1.3 -0.5 -0.8 -0.6 0.0 -0.2 0.1 -0.5 -0.5
Medication for cholesterol 0.8 1.3 1.8 1.3 1.2 -1.2 -1.1 -1.2 -1.3 -0.8 -0.8 -1.1 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.9 0.5 -0.2 0.7 0.6 0.6 0.9 0.7 0.4 0.7 0.7
Back pain experienced in last month 0.2 0.2 1.6 0.5 0.3 -0.2 -0.5 -0.1 -0.2 -0.1 1.3 -0.2 -0.2
Mineral and other dietary supplements 0.1 0.2 0.5 -0.1 0.4 -0.5 -0.4 -0.6 -0.1 -0.2 -0.7 -0.4 -0.4
Breast cancer (self-reported) 1.3 1.6 8.1 -2.2 -0.5 0.5 0.5 1.0 0.4 0.7 2.8 0.5 0.5
Asthma (self-reported) 0.5 1.1 5.1 1.5 -2.2 0.1 -0.2 0.3 0.6 1.0 1.3 0.2 0.2
Osteoporosis (self-reported) 0.1 0.1 0.5 0.2 -0.2 0.4 0.3 0.3 0.2 0.7 0.2 0.4 0.4
Osteoarthritis (self-reported) 0.1 0.2 1.0 0.7 -0.0 -0.2 -0.4 -0.0 -0.1 -0.1 1.0 -0.2 -0.2
Medication: Aspirin 0.7 0.9 1.2 -0.6 1.1 -1.0 -1.1 -1.1 -0.6 -1.1 -1.0 -1.0 -1.0
Medication: Gliclazide 0.1 0.1 0.5 -0.6 0.2 0.2 0.2 0.3 0.3 0.0 0.7 0.2 0.2
Illnesses of father: None of the above (group 1) 2.7 3.4 6.1 0.0 2.5 -1.9 -1.7 -2.0 -1.8 -2.0 -1.8 -1.9 -1.9
Smoking status: Current 8.7 13.8 19.4 -2.2 3.6 -3.9 -3.6 -4.0 -3.6 -4.4 -3.8 -3.8 -3.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.2 1.5 -0.9 -0.1 -0.0 -0.4 0.6 -0.0 -1.5 -0.1 -0.1
Whole body water mass 1.7 9.8 13.5 0.9 -3.1 3.7 3.7 3.2 3.1 3.3 1.7 3.6 3.6
Leg predicted mass (right) 2.9 15.6 20.0 1.2 -4.1 4.5 4.4 4.1 4.1 4.4 2.6 4.4 4.4
Arm fat mass (left) 4.9 19.9 24.8 0.8 -5.0 4.8 4.7 4.7 4.8 5.0 3.6 4.8 4.8
Number of self-reported non-cancer illnesses 5.9 10.3 13.4 1.5 -3.6 3.3 3.1 3.3 3.7 3.5 3.1 3.3 3.3
Average weekly champagne plus white wine intake 0.2 0.3 1.5 0.5 -1.2 0.3 0.2 0.3 0.3 0.3 0.7 0.3 0.3
Miserableness 2.4 4.1 6.9 0.0 -2.0 1.9 1.8 2.2 2.5 2.3 2.6 1.9 1.9
Guilty feelings 3.2 4.9 8.4 1.8 -1.9 2.1 1.9 2.2 2.9 2.3 2.6 2.1 2.1
Wears glasses or contact lenses 4.9 5.6 6.6 1.0 -2.4 2.5 2.4 2.5 2.6 2.5 2.5 2.5 2.5
Ever taken oral contraceptive pill 3.4 3.8 6.0 -0.8 2.5 -2.2 -2.2 -2.0 -2.0 -2.1 -0.8 -2.1 -2.1
Hearing aid user 0.4 0.5 1.0 -0.6 -1.0 0.7 0.8 0.7 0.8 0.3 0.4 0.7 0.7
Mother’s age at death 2.5 3.1 6.2 -0.3 1.2 -1.8 -1.8 -1.9 -1.8 -1.9 -2.5 -1.8 -1.8
Financial situation satisfaction 0.6 0.8 3.5 0.5 -1.9 0.7 0.6 0.6 1.1 0.8 -0.2 0.7 0.7
Tinnitus: Yes, now most or all of the time 0.2 0.3 1.3 1.1 0.7 0.4 0.4 0.4 -0.3 0.4 0.1 0.4 0.4
Commuting to job workplace: Public transport 7.2 8.6 11.4 0.2 3.1 -3.0 -2.9 -3.3 -2.9 -3.1 -3.4 -3.0 -3.0
Eye problems/disorders: Glaucoma 1.2 1.4 2.9 1.7 1.4 -1.2 -1.6 -1.1 -0.8 -0.6 0.5 -1.2 -1.2
Medication: Blood pressure 0.3 0.6 0.9 0.5 -0.6 0.9 0.9 0.8 0.9 0.8 -0.0 0.9 0.9
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.6 -0.0 1.6 -0.9 -1.0 -1.0 -1.1 -1.1 -0.5 -0.9 -0.9
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.9 0.2 -1.4 0.5 0.3 0.7 0.4 0.3 1.2 0.5 0.5
High cholesterol (Self-reported) 1.3 2.3 7.7 -2.8 -0.6 1.3 1.4 1.5 1.7 0.8 1.5 1.3 1.3
Medication: Bendroflumethiazide 0.1 0.1 0.5 0.4 0.7 -0.1 -0.0 -0.1 0.3 -0.1 -0.7 -0.1 -0.1
Medication: Paracetamol 0.9 1.4 8.1 2.8 -0.9 0.7 0.7 0.6 1.2 0.9 0.3 0.8 0.8
Medication: Lisinopril 0.2 0.2 0.7 0.6 -0.2 -0.4 -0.4 -0.6 0.0 -0.1 -0.8 -0.4 -0.4
Medication: Atorvastatin 1.2 1.4 2.6 -0.8 -1.1 1.2 1.2 1.3 1.2 1.1 1.6 1.2 1.2
Illnesses of father: High blood pressure 1.5 1.9 7.0 2.6 -0.9 1.3 1.2 1.0 1.1 1.6 -0.0 1.3 1.3
Alcohol drinker status: Never 1.9 2.3 4.4 2.1 -1.5 1.5 1.4 1.2 1.9 1.5 0.4 1.4 1.4
Ever smoked 0.8 1.4 2.0 -1.1 0.9 -1.4 -1.4 -1.3 -0.7 -1.1 -0.3 -1.4 -1.4
Basal metabolic rate 2.4 13.4 17.6 1.1 -3.8 4.2 4.2 3.8 3.7 4.0 2.3 4.2 4.2
Leg fat percentage (left) 2.6 9.5 13.0 0.4 -3.0 3.3 3.2 3.3 3.6 3.4 2.9 3.3 3.3
Arm fat-free mass (left) 1.9 9.7 14.0 0.8 -2.9 3.7 3.7 3.2 3.1 3.2 1.8 3.7 3.7
Number of operations (self-reported) 0.3 0.5 3.8 -2.0 0.6 -0.2 -0.3 0.1 -0.0 -0.5 0.3 -0.3 -0.3
Average weekly beer plus cider intake 2.6 3.8 6.4 -1.8 1.3 -2.0 -1.8 -1.8 -2.3 -2.5 -1.5 -2.0 -2.0
Irritability 8.5 14.4 19.3 3.7 -3.6 3.8 3.4 3.8 4.0 4.4 3.4 3.8 3.8
Risk taking 0.8 1.2 1.7 -1.0 0.9 -1.2 -1.1 -1.1 -1.1 -1.3 -0.6 -1.2 -1.2
Ever had prostate specific antigen (PSA) test 0.8 1.0 1.4 -0.9 -0.5 1.1 1.0 1.1 0.9 0.9 1.2 1.0 1.0
Fractured/broken bones in last 5 years 0.5 0.6 0.8 -0.4 -0.9 0.8 0.9 0.9 0.4 0.8 0.8 0.9 0.9
Age started oral contraceptive pill 0.8 1.0 2.6 -0.6 -0.5 1.0 1.0 0.9 1.0 1.0 -1.6 1.0 1.0
Diastolic blood pressure, automated reading 3.3 10.3 13.7 1.6 -3.0 3.7 3.7 3.4 3.4 3.5 1.4 3.7 3.7
Ever depressed for a whole week 2.7 3.4 6.1 1.0 -1.9 1.8 1.7 1.7 2.1 1.7 2.5 1.8 1.8
Unable to work because of sickness or disability 0.3 0.4 1.3 1.1 0.8 -0.6 -0.6 -0.6 -0.4 -0.7 -0.0 -0.6 -0.6
Commuting to job workplace: Cycle 0.8 1.0 1.5 0.1 -0.8 1.1 1.2 1.1 0.9 1.2 0.5 1.1 1.1
Myopia 6.0 8.7 13.5 0.4 3.1 -3.0 -2.9 -3.3 -3.0 -3.0 -3.7 -3.0 -3.0
Vascular/heart problems diagnosed by doctor 1.0 2.8 3.9 -0.9 1.4 -1.9 -2.0 -1.8 -1.9 -1.6 -0.6 -2.0 -2.0
Cholesterol lowering medication 2.5 3.7 6.2 -2.5 -2.1 1.8 1.7 1.9 2.1 1.5 2.0 1.8 1.8
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.5 1.2 0.0 -0.8 -1.0 -0.7 -0.2 -0.2 0.8 -0.8 -0.8
Pain experienced in last month 0.2 0.4 2.5 0.8 0.4 -0.1 0.1 -0.3 -0.5 0.3 -1.6 -0.0 -0.0
Supplements: Calcium 0.5 0.6 1.2 -0.0 -1.0 0.7 0.5 0.9 0.5 1.1 0.7 0.7 0.7
Basal cell carcinoma (self-reported) 1.8 2.2 11.4 3.4 -0.9 0.8 0.5 0.7 1.7 1.6 1.3 0.8 0.8
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.5 1.6 0.4 -1.2 -1.4 -1.3 -1.1 -0.9 -0.9 -1.1 -1.1
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 1.2 -0.3 -0.1 1.0 1.1 0.9 1.1 0.8 0.1 1.0 1.0
Heart disease (siblings) 0.2 0.3 1.8 0.4 -0.3 -0.3 -0.3 -0.5 0.1 -0.5 -1.4 -0.4 -0.4
Alcohol drinker status: Previous 0.2 0.2 1.2 1.1 0.2 0.3 0.2 0.4 0.6 0.3 0.3 0.2 0.2
Pack years of smoking 0.6 0.8 7.2 -2.7 0.1 0.2 0.4 0.2 -0.2 -0.3 -0.7 0.2 0.2
Impedance of whole body 0.9 4.5 20.5 4.5 -0.4 -2.1 -2.5 -1.8 -1.2 -0.6 0.3 -2.1 -2.1
Leg fat mass (left) 3.5 13.8 17.0 0.7 -3.6 4.1 4.0 3.9 4.1 4.1 3.1 4.1 4.1
Arm predicted mass (left) 1.6 8.1 11.6 0.7 -2.7 3.4 3.4 3.0 2.9 2.9 1.5 3.3 3.3