Hub : Genes

RP4-781K5.2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.421 0.114 0.00310 -0.011 NA 0.051 NA 0.004 0.83000 NA 2.0e-02 NA 0.25000
2 GTEx Testis 0.268 0.084 0.00073 0.080 NA 0.089 NA 0.074 0.00021 NA 9.2e-05 NA 0.00036

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.0 0.0 0.0 -0.2 -0.1
Bipolar Disorder or Schizophrenia 1.0 2.3 4.7 2.2 0.1
Depressed Affect (Nagel 2018) 0.4 0.9 1.8 1.4 0.0
Depression (Nagel 2018) 0.2 0.3 0.7 -0.1 -0.8
Intelligence (Savage-Jansen 2018) 1.9 5.7 11.4 -0.1 3.4
Neuroticism (Nagel 2018) 1.1 2.6 5.1 0.4 2.3
Schizophrenia (2018) 1.9 3.9 7.7 2.8 0.0
Schizophrenia vs Biploar Disorder 1.4 1.9 2.8 1.7 1.0
Worry (Nagel 2018) 2.3 4.9 9.8 -0.2 3.1
Alzheimer’s Disease (in mother) 0.2 0.2 0.5 -0.1 -0.7
Alzheimer’s Disease (in father) 0.7 0.8 0.9 -0.9 0.8
Alzheimer’s Disease (including proxy) 0.2 0.3 0.3 -0.6 -0.5
Crohns Disease (2017) 3.9 8.5 15.5 1.2 -3.9
Irritable Bowel Disease (IBD) 2.4 5.8 10.6 1.0 -3.3
Ulcerative Colitis (UC) 0.8 1.4 2.7 0.4 -1.6
Major Depression (MDD) 0.4 0.4 0.8 0.9 -0.2
Reaction Time 0.4 0.7 0.9 0.9 -0.8
Verbal and Numeric Reasoning (VNR) 1.4 3.3 6.7 -0.1 2.6
Breast Cancer 0.3 0.7 1.0 -1.0 0.6
Ovarian Cancer 0.4 0.5 0.7 -0.5 -0.8
Prostate Cancer 0.2 0.3 0.5 -0.3 0.7
Age at First Birth 2.8 4.1 6.1 -1.4 2.5
Bipolar Disorder (2011) 1.5 1.5 2.9 -0.3 -1.7
Body Mass Index (BMI) (2010) 1.1 1.4 2.2 -0.8 -1.5
Coronary Artery Disease (CAD) 3.1 3.7 4.8 2.2 -1.6
Crohns Disease (2012) 4.9 7.8 11.1 2.1 -3.3
Mean Putamen Volume 0.5 0.6 1.0 -0.4 1.0
Fasting Glucose 0.9 1.1 1.8 1.3 -0.7
HbA1C 0.4 0.4 0.5 -0.6 0.7
HDL Cholesterol 0.2 0.3 0.3 0.5 0.5
LDL Cholesterol 1.8 2.9 5.4 0.6 -2.3
Lupus 0.4 0.6 1.1 -0.5 1.0
Neuroticism (2016) 0.2 0.3 0.4 0.6 -0.4
Primary Biliary Cirrhosis 0.2 0.3 0.3 0.5 -0.5
Rheumatoid Arthritis 0.0 0.0 0.0 0.1 -0.1
Schizophrenia (2014) 1.8 3.9 7.9 2.8 -0.0
Triglycerides 0.2 0.4 0.7 -0.3 -0.8
Type 2 Diabetes (T2D) (2012) 0.9 1.1 2.0 1.4 -0.4
Ulcerative Colitis 1.0 1.4 1.5 1.2 -1.1
Blood Eosinophil Count 0.5 4.2 7.1 -1.2 -2.7
Blood Platelet Count 0.5 6.1 12.1 -0.1 -3.5
Blood Red Count 0.8 8.0 12.5 1.9 -3.5
Blood White Count 0.2 1.2 1.5 1.2 -0.9
Heel T-Score 2.1 16.9 33.8 0.3 5.8
BMI 1.0 5.7 10.4 1.0 -3.2
Height 0.2 3.3 6.1 2.5 -0.7
Waist Hip Ratio (WHR) 0.1 0.3 0.4 -0.6 -0.4
Systolic Blood Pressure 0.1 0.3 0.4 0.5 -0.7
Smoking Status 2.0 4.8 5.8 1.9 -2.4
Allergy or Eczema 0.7 1.8 2.9 -1.7 0.9
Cardiovascular Disease 2.2 7.2 9.1 2.3 -3.0
Hypothyroidism (self reported) 0.5 1.2 2.3 -0.2 -1.5
Respiratory disease 0.5 1.1 1.8 -1.3 -0.6
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.2 0.0 -1.1
Lung FEV1/FVC ratio 0.1 0.6 0.8 -0.7 0.9
Lung FVC 0.0 0.2 0.4 -0.2 -0.6
Neuroticism 0.6 1.5 2.9 0.3 1.7
Chronotype (morning person) 0.2 0.4 0.8 0.1 -0.9
Hair Pigment 0.0 0.4 0.6 0.4 -0.7
Tanning 0.2 2.8 4.0 1.3 -2.0
Hand grip strength (left) 0.8 2.2 2.3 -1.5 1.5
Number of treatments/medications taken 3.0 5.5 8.9 1.4 -3.0
Average weekly spirits intake 0.6 0.8 1.5 1.2 0.3
Sensitivity / hurt feelings 2.3 3.9 7.1 -0.8 2.7
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 0.4 0.2
Hearing difficulty/problems: Yes 0.1 0.2 0.2 -0.5 0.4
Relative age of first facial hair 1.2 2.5 4.8 -2.2 0.5
Other serious medical condition/disability diagnosed by doctor 3.4 4.4 6.5 1.5 -2.5
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.6 -0.1 -0.8
Ever had hysterectomy (womb removed) 3.9 4.4 8.2 0.8 -2.9
Systolic blood pressure, automated reading 0.3 0.9 0.9 0.9 -1.0
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 1.9 1.1 -1.4
Angina 5.5 7.2 9.9 2.1 -3.1
Medication for hormone replacement therapy 2.6 2.9 3.1 -1.8 1.6
Vitamin and mineral supplements 0.2 0.3 0.4 0.4 0.7
Supplements: Zinc 0.6 0.6 0.7 -0.8 0.7
Medication: Co-codamol 2.3 2.7 3.4 1.4 -1.8
Medication: Metformin 0.1 0.2 0.2 -0.4 -0.4
Diabetes (father) 0.5 0.7 1.2 -1.1 -0.4
Diabetes (mother) 0.2 0.3 0.5 0.1 -0.7
Severe depression (siblings) 0.3 0.3 0.5 0.7 0.4
Pack years adult smoking proportion 0.3 0.5 0.9 -0.3 -1.0
Impedance of leg (right) 0.1 0.6 1.2 0.1 1.1
Leg fat-free mass (left) 0.3 1.4 2.2 0.7 -1.5
Trunk fat percentage 1.6 6.2 10.3 1.5 -3.2
Hand grip strength (right) 0.4 1.0 1.3 -1.1 0.8
Townsend deprivation index at recruitment 0.8 1.1 1.1 1.1 -1.1
Current tobacco smoking 0.9 1.4 2.5 0.6 -1.6
Average weekly fortified wine intake 0.2 0.2 0.4 -0.3 0.6
Maternal smoking around birth 1.3 1.9 1.9 -1.4 -1.3
Fed-up feelings 0.1 0.2 0.5 0.7 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.2 -0.5 -0.2
Relative age voice broke 3.0 4.6 7.9 -2.8 1.2
Taking other prescription medications 2.2 3.4 6.2 0.8 -2.5
Age when periods started (menarche) 1.0 2.5 2.9 1.7 1.4
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 2.6 0.1 -1.6
Heel bone mineral density (BMD) T-score, automated (left) 2.7 6.2 8.8 -1.9 3.0
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 3.3 -1.8 0.9
Qualifications: CSEs or equivalent 2.6 3.4 5.3 -2.3 1.2
Serious illness, injury or assault to yourself 0.1 0.1 0.1 -0.0 -0.4
High blood pressure 1.4 4.0 5.1 1.7 -2.3
Hayfever, allergic rhinitis or eczema 1.8 3.8 4.8 -1.7 2.2
Multivitamins +/- minerals 0.4 0.5 1.0 -1.0 0.3
Stomach or abdominal pain in last month 2.6 3.2 6.2 -0.5 -2.5
Supplements: Glucosamine 0.0 0.1 0.1 -0.3 -0.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.5 -0.1 -0.7
Medication: Atenolol 1.3 1.6 3.2 0.2 -1.8
Medication: Levothyroxine sodium 0.6 1.0 1.2 1.0 -1.1
Sitting height 0.1 0.6 1.1 0.1 1.1
Chronic bronchitis/emphysema (father) 1.7 2.0 4.0 2.0 -0.1
High blood pressure (mother) 0.2 0.3 0.5 -0.7 0.3
Body mass index (BMI) 1.6 6.8 11.6 1.5 -3.4
Impedance of leg (left) 0.0 0.0 0.0 0.2 -0.0
Leg predicted mass (left) 0.2 1.1 1.9 0.6 -1.4
Trunk fat mass 1.6 6.9 11.8 1.4 -3.4
Waist circumference 1.5 5.3 10.1 0.7 -3.2
Number of incorrect matches in round 0.1 0.2 0.2 0.5 -0.4
Past tobacco smoking 0.9 1.7 3.3 -1.8 -0.2
Alcohol usually taken with meals 0.7 1.1 1.4 0.9 1.2
Nervous feelings 1.8 3.4 6.7 -0.5 2.6
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 2.5 0.6 -1.6
Hearing difficulty/problems with background noise 0.9 1.4 1.7 -1.3 1.1
Hair/balding pattern: Pattern 2 1.5 1.9 2.1 -1.4 1.3
Had menopause 0.1 0.1 0.2 0.4 -0.2
Had other major operations 0.6 0.7 1.4 -1.2 -0.2
Forced vital capacity (FVC) 0.2 0.6 1.1 -1.1 0.3
Heel bone mineral density (BMD) T-score, automated (right) 3.0 6.8 10.0 -1.9 3.2
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.5 0.4 -0.7
Qualifications: None of the above 5.2 11.2 15.1 2.7 -3.9
Financial difficulties in last 2 years 1.9 2.6 4.9 -0.5 -2.2
Mouth/teeth dental problems 1.5 2.4 4.7 -2.2 -0.2
Heart attack 4.2 5.4 10.7 0.2 -3.3
Allergy 0.9 2.0 2.2 1.3 -1.5
Pain all over the body in last month 0.3 0.3 0.7 -0.8 0.1
Diabetes (self-reported) 0.3 0.4 0.8 0.0 -0.9
Hayfever/allergic rhinitis (self-reported) 1.7 2.2 2.9 -1.7 1.2
Medication: Ramipril 3.7 4.7 8.2 1.1 -2.9
Medication: Simvastatin 5.4 8.0 13.6 1.5 -3.7
Fluid intelligence score 1.2 2.6 4.8 -0.6 2.2
Illnesses of siblings 1.9 2.7 4.2 -2.1 1.0
Neuroticism score 0.9 1.8 3.6 0.2 1.9
Weight 1.2 6.0 10.0 1.4 -3.2
Impedance of arm (right) 1.0 4.5 8.1 -0.9 2.9
Arm fat percentage (right) 1.0 3.9 5.9 1.4 -2.4
Trunk fat-free mass 0.2 1.1 1.8 0.7 -1.3
Hip circumference 1.4 6.1 10.4 1.3 -3.2
Time employed in main current job 0.0 0.0 0.1 -0.3 0.2
Alcohol intake versus 10 years previously 1.4 2.1 2.2 -1.5 -1.4
Father’s age at death 0.6 0.9 1.2 -0.7 1.1
Worrier / anxious feelings 3.2 6.0 11.9 0.2 3.5
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.2 0.3 -0.5
Falls in the last year 0.4 0.5 1.1 -0.1 -1.0
Hair/balding pattern: Pattern 3 0.4 0.6 1.1 1.1 0.1
Number of live births 0.3 0.5 0.8 0.3 -0.9
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 3.3 -1.8 0.8
Pulse rate 0.0 0.1 0.1 0.4 -0.2
Happiness 1.4 1.7 3.3 0.3 1.8
Noisy workplace 0.8 1.0 1.4 0.7 -1.2
Qualifications: A levels/AS levels or equivalent 3.3 7.3 11.0 -1.9 3.3
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.0 -0.1 0.1
Mouth/teeth dental problems: Dentures 1.7 2.8 4.6 2.1 -1.0
Asthma 0.7 1.4 2.6 -1.6 0.4
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 0.8 0.7 0.9
Medication: Cholesterol lowering 4.3 6.6 7.6 2.4 -2.8
Depression (self-reported) 2.4 2.9 4.1 2.0 -1.3
Medication: Lansoprazole 3.2 3.7 7.2 -0.4 -2.7
Prospective memory result 0.1 0.2 0.4 0.0 -0.6
Lung cancer (father) 2.1 2.4 4.2 0.8 2.1
Illnesses of mother 1.5 1.9 2.6 -1.1 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 1.2 -1.1 0.7
Pulse wave Arterial Stiffness index 1.0 1.2 1.4 1.2 1.0
Impedance of arm (left) 0.9 4.0 6.8 -1.1 2.6
Arm fat mass (right) 1.5 6.1 9.4 1.7 -3.1
Trunk predicted mass 0.2 1.3 2.0 0.8 -1.4
Standing height 0.0 0.0 0.0 -0.1 0.2
Length of working week for main job 0.5 0.5 0.5 0.7 -0.7
Exposure to tobacco smoke at home 4.4 5.0 5.4 2.1 -2.3
Breastfed as a baby 4.2 5.2 7.2 1.8 2.7
Tense / ‘highly strung’ 1.2 2.0 3.9 0.1 2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.2 3.4 -1.8 1.7
Hair/balding pattern: Pattern 4 1.5 3.5 5.4 1.3 -2.3
Birth weight of first child 1.0 1.7 3.5 0.0 -1.9
Peak expiratory flow (PEF) 1.6 3.8 4.7 -1.7 2.2
Pulse wave reflection index 0.4 0.5 0.9 0.2 1.0
Ever highly irritable/argumentative for 2 days 2.9 3.4 5.7 1.1 2.4
Loud music exposure frequency 2.7 2.9 5.8 -0.0 2.4
Qualifications: O levels/GCSEs or equivalent 2.2 3.6 6.2 -0.9 2.5
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.6 0.5 0.7
Blood clot in the leg (DVT) 0.2 0.2 0.2 0.5 -0.5
Medication: Paracetamol 1.4 2.3 2.4 1.5 -1.5
Headache pain in last month 0.2 0.3 0.5 0.4 0.7
Medication for cholesterol, blood pressure or diabetes 2.3 3.8 4.1 -2.0 1.9
Glaucoma (self-reported) 0.4 0.5 0.9 0.9 0.3
Gout (self-reported) 1.1 1.5 1.6 1.3 1.2
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.4 -0.1 -1.6
Medication: Amlodipine 0.2 0.3 0.5 0.1 -0.7
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.4 -0.3
Birth weight 1.2 2.6 4.7 0.7 -2.2
Chronic bronchitis/emphysema (mother) 0.9 1.0 2.0 1.4 -0.4
High blood pressure (siblings) 3.5 5.0 8.9 3.0 -1.1
Forced vital capacity (FVC), Best measure 0.0 0.1 0.1 -0.4 0.2
Body fat percentage 2.1 8.4 13.2 1.9 -3.6
Leg fat percentage (right) 2.6 9.4 14.6 2.0 -3.8
Arm fat-free mass (right) 0.8 4.1 7.0 1.1 -2.6
Exposure to tobacco smoke outside home 0.0 0.0 0.0 -0.1 0.1
Comparative body size at age 10 0.9 2.6 4.9 0.5 -2.2
Number of full brothers 0.0 0.1 0.1 0.4 0.0
Worry too long after embarrassment 1.5 2.5 3.7 -1.1 1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.1 0.3 -0.1
Wheeze or whistling in the chest in last year 1.3 2.2 4.1 0.6 -2.0
Number of children fathered 0.3 0.3 0.4 0.6 0.4
Reason for reducing amount of alcohol drunk: Health precaution 2.1 2.5 4.2 2.0 -0.9
Age at first live birth 3.0 5.3 10.1 -0.7 3.2
Pulse wave peak to peak time 0.9 1.0 1.7 -1.3 -0.6
Health satisfaction 1.4 1.8 2.8 0.9 -1.7
Shortness of breath walking on level ground 3.9 4.6 8.6 0.7 -2.9
Qualifications: College or University degree 2.3 7.2 9.8 -2.2 3.1
Eye problems/disorders: None of the above 2.3 2.7 5.2 -0.4 2.3
Mouth/teeth dental problems: Loose teeth 3.6 4.3 6.4 -1.5 2.5
Emphysema/chronic bronchitis 0.8 1.0 1.6 0.6 -1.2
Medication for pain relief, constipation, heartburn 0.6 0.9 1.5 -0.6 1.2
Neck or shoulder pain in last month 3.3 4.6 5.3 2.3 -2.0
Medication: Blood pressure 0.6 1.1 1.3 1.1 -1.0
Angina (self-reported) 5.8 7.7 10.2 2.3 -3.2
Migraine (self-reported) 0.2 0.2 0.2 -0.4 0.5
Medication: Ibuprofen 0.5 0.6 1.0 -0.3 1.0
Medication: Allopurinol 1.2 1.6 2.4 1.6 0.9
Medication: Omeprazole 1.7 2.1 3.8 -0.5 -2.0
Medication: Seretide 50 evohaler 0.0 0.0 0.0 -0.2 0.1
Mean time to correctly identify matches 0.7 1.4 2.6 1.6 -0.5
Heart disease (mother) 2.8 3.4 6.8 0.3 -2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.6 4.3 8.4 -0.5 2.9
Whole body fat mass 1.9 8.0 13.1 1.7 -3.6
Leg fat mass (right) 2.1 8.3 13.8 1.7 -3.7
Arm predicted mass (right) 0.9 4.4 7.6 1.1 -2.8
Pulse rate, automated reading 0.3 1.1 2.1 1.4 -0.2
Alcohol intake frequency. 0.7 1.7 2.5 1.0 -1.6
Comparative height size at age 10 0.5 2.5 4.0 1.0 -2.0
Number of full sisters 0.9 1.1 2.1 1.5 -0.4
Suffer from ‘nerves’ 0.0 0.0 0.1 0.3 0.1
Overall health rating 4.6 10.0 19.6 0.5 -4.4
Chest pain or discomfort 0.1 0.1 0.1 -0.4 -0.2
Had major operations 0.4 0.4 0.9 -0.1 -0.9
Age at last live birth 4.1 6.0 10.5 -1.2 3.2
Family relationship satisfaction 0.0 0.0 0.0 0.1 0.1
Leg pain on walking 0.1 0.2 0.2 0.3 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.0 -1.0 0.6
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.6 -0.1 0.8
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.7 -0.8 0.6
Medication: Aspirin 3.1 4.1 5.8 2.4 -1.5
Supplements: Vitamin C 0.0 0.0 0.0 -0.0 -0.0
Knee pain experienced in last month 1.2 1.9 2.5 1.6 -1.2
Hypertension (Self-reported) 1.0 2.9 3.3 1.6 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 1.6 -1.0 -1.3
Illnesses of father: Heart disease 1.2 1.7 2.3 1.5 -1.0
Illnesses of siblings: Diabetes 1.2 1.4 1.6 1.3 -1.1
Smoking status: Previous 1.9 2.9 5.7 2.4 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.6 -0.8 -0.5
Whole body fat-free mass 0.3 1.7 2.9 0.7 -1.7
Leg fat-free mass (right) 0.3 1.7 3.1 0.5 -1.8
Arm fat percentage (left) 1.0 4.0 6.6 1.2 -2.6
Average weekly red wine intake 1.1 1.6 2.1 1.4 1.1
Handedness (chirality/laterality): Left-handed 1.6 1.9 3.3 1.8 -0.7
Mood swings 0.3 0.6 0.6 0.8 0.7
Loneliness, isolation 1.1 1.5 2.1 1.5 -0.9
Long-standing illness, disability or infirmity 0.9 1.4 2.4 -0.6 -1.6
Ever had bowel cancer screening 0.3 0.4 0.8 -0.1 -0.9
Diabetes diagnosed by doctor 0.7 1.1 2.0 0.5 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.1 0.1 -1.0
Friendships satisfaction 0.9 1.2 1.8 -0.7 1.4
Qualifications: nursing, teaching 2.7 4.1 6.2 -1.4 2.5
Commuting to job workplace: Walk 1.5 1.6 3.2 -0.3 1.8
Eye problems/disorders: Cataract 0.3 0.4 0.8 -0.2 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.7 0.5 -0.8
Medication for cholesterol 0.8 1.2 1.8 -0.8 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.6 -0.6 -0.8
Back pain experienced in last month 3.2 4.7 5.4 2.3 -2.0
Mineral and other dietary supplements 0.2 0.2 0.3 0.6 -0.4
Breast cancer (self-reported) 0.4 0.5 0.8 -0.9 0.4
Asthma (self-reported) 0.6 1.2 2.3 -1.5 0.1
Osteoporosis (self-reported) 0.0 0.0 0.0 0.2 -0.1
Osteoarthritis (self-reported) 1.2 1.6 1.9 1.1 -1.4
Medication: Aspirin 2.9 3.8 6.0 2.5 -1.3
Medication: Gliclazide 1.2 1.4 2.2 -1.5 -0.7
Illnesses of father: None of the above (group 1) 1.5 1.9 2.7 -1.7 1.0
Smoking status: Current 0.8 1.3 2.5 0.3 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 0.8 -0.6 0.9
Whole body water mass 0.3 1.7 2.7 0.8 -1.6
Leg predicted mass (right) 0.3 1.6 2.8 0.6 -1.7
Arm fat mass (left) 1.5 6.1 9.8 1.5 -3.1
Number of self-reported non-cancer illnesses 2.3 4.1 8.1 0.3 -2.8
Average weekly champagne plus white wine intake 1.0 1.4 2.1 -1.4 0.9
Miserableness 0.1 0.2 0.3 0.6 0.2
Guilty feelings 0.5 0.8 0.8 0.9 0.9
Wears glasses or contact lenses 1.5 1.8 2.1 -1.2 1.5
Ever taken oral contraceptive pill 2.0 2.2 2.3 1.5 -1.4
Hearing aid user 0.6 0.7 1.0 0.6 -1.0
Mother’s age at death 1.1 1.3 1.9 -0.9 1.4
Financial situation satisfaction 1.4 1.8 3.3 0.5 -1.8
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.1 0.4 -0.1
Commuting to job workplace: Public transport 0.1 0.1 0.1 -0.2 0.3
Eye problems/disorders: Glaucoma 0.6 0.7 0.8 0.9 -0.7
Medication: Blood pressure 1.8 3.4 4.8 1.4 -2.2
Pain type(s) experienced in last month: Hip pain 1.2 1.5 2.0 1.0 -1.4
Supplements: Fish oil (including cod liver oil) 0.3 0.3 0.6 -0.7 -0.3
High cholesterol (Self-reported) 5.3 9.3 10.8 2.8 -3.3
Medication: Bendroflumethiazide 0.1 0.1 0.2 0.0 -0.5
Medication: Paracetamol 1.0 1.6 1.7 1.2 -1.3
Medication: Lisinopril 0.7 1.0 1.5 -0.7 1.2
Medication: Atorvastatin 4.8 5.9 9.4 3.1 -1.6
Illnesses of father: High blood pressure 0.1 0.1 0.1 0.1 0.4
Alcohol drinker status: Never 0.7 0.9 1.7 0.4 -1.3
Ever smoked 0.5 0.8 1.6 1.2 0.2
Basal metabolic rate 0.5 2.8 4.8 0.9 -2.2
Leg fat percentage (left) 3.2 11.7 19.4 2.0 -4.4
Arm fat-free mass (left) 1.1 5.8 9.2 1.5 -3.0
Number of operations (self-reported) 0.4 0.6 1.2 -1.1 -0.3
Average weekly beer plus cider intake 0.0 0.1 0.1 -0.2 0.3
Irritability 1.5 2.6 3.2 -1.4 1.8
Risk taking 1.0 1.4 2.4 0.6 -1.6
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.3 0.5 -0.5
Fractured/broken bones in last 5 years 2.5 3.2 4.1 1.5 -2.0
Age started oral contraceptive pill 0.7 0.9 1.6 1.2 -0.5
Diastolic blood pressure, automated reading 1.9 5.7 9.4 1.4 -3.1
Ever depressed for a whole week 0.6 0.7 1.3 -1.2 0.4
Unable to work because of sickness or disability 6.8 8.9 17.7 0.1 -4.2
Commuting to job workplace: Cycle 2.1 2.6 3.8 1.9 1.1
Myopia 7.0 10.2 15.6 -2.2 4.0
Vascular/heart problems diagnosed by doctor 2.7 7.5 10.9 -2.0 3.3
Cholesterol lowering medication 4.6 6.8 10.4 1.8 -3.2
Medication: Omeprazole (e.g. Zanprol) 1.0 1.3 2.5 0.0 -1.6
Pain experienced in last month 2.5 4.1 4.4 -2.0 2.1
Supplements: Calcium 0.8 0.9 1.7 -0.3 -1.3
Basal cell carcinoma (self-reported) 0.1 0.2 0.2 0.4 0.4
Heart attack/myocardial infarction (self-reported) 4.6 6.0 11.9 0.2 -3.5
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.1 0.4 -0.4
Heart disease (siblings) 3.2 4.0 6.1 1.4 -2.5
Alcohol drinker status: Previous 0.9 1.0 1.5 1.2 -0.7
Pack years of smoking 0.5 0.7 1.4 0.2 -1.2
Impedance of whole body 0.3 1.7 3.0 -0.6 1.7
Leg fat mass (left) 2.5 9.8 16.9 1.6 -4.1
Arm predicted mass (left) 1.2 6.2 9.7 1.7 -3.1