Hub : Genes

RP5-1087E8.3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1242	0.0517	0.00048	0.034	NA	0.068	NA	0.033	1.0e-03	NA	5.2e-06	NA	1.2e-03
2	GTEx	Esophagus Muscularis	0.0870	0.0350	0.00200	0.004	NA	0.010	NA	0.015	1.7e-01	NA	7.7e-02	NA	4.2e-02
3	GTEx	Muscle Skeletal	0.0591	0.0214	0.00014	0.048	NA	0.053	NA	0.060	1.6e-05	NA	6.1e-06	NA	1.4e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.8	0.9	-0.7	0.9	1.0
Bipolar Disorder or Schizophrenia	0.9	2.2	5.7	-2.4	-0.8	0.4
Depressed Affect (Nagel 2018)	1.1	2.4	5.0	-0.9	-2.2	-1.1
Depression (Nagel 2018)	0.5	0.8	1.5	-0.7	-1.2	-0.6
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.3	0.3	-1.1	0.3
Neuroticism (Nagel 2018)	3.2	7.6	12.1	-2.5	-3.5	-2.1
Schizophrenia (2018)	1.5	3.2	6.4	-2.5	-1.8	-0.3
Schizophrenia vs Biploar Disorder	0.4	0.5	1.2	0.6	1.1	-0.3
Worry (Nagel 2018)	3.9	8.2	15.6	-2.5	-3.9	-1.6
Alzheimer’s Disease (in mother)	0.3	0.4	0.8	-0.3	-0.5	-0.9
Alzheimer’s Disease (in father)	2.6	2.9	4.4	2.1	1.4	1.5
Alzheimer’s Disease (including proxy)	0.6	0.8	1.4	1.2	0.8	0.7
Crohns Disease (2017)	0.3	0.7	1.8	0.0	-0.5	-1.4
Irritable Bowel Disease (IBD)	1.2	2.8	3.8	-1.1	-1.8	-2.0
Ulcerative Colitis (UC)	1.7	3.2	4.7	-1.5	-1.7	-2.2
Major Depression (MDD)	2.4	2.9	3.8	-1.9	-1.3	-1.8
Reaction Time	1.0	2.0	5.2	0.7	-0.4	-2.3
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.4	0.2	-1.1	-1.5
Breast Cancer	0.5	1.1	1.4	1.2	-1.1	0.9
Ovarian Cancer	0.2	0.3	0.5	-0.7	-0.5	-0.5
Prostate Cancer	1.1	1.6	2.7	-1.6	-1.4	0.4
Age at First Birth	1.3	1.9	2.2	-1.4	-1.5	1.2
Bipolar Disorder (2011)	0.6	0.6	1.0	-0.8	0.3	-1.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.5	0.2	-0.1
Coronary Artery Disease (CAD)	0.4	0.5	0.9	0.9	0.6	0.4
Crohns Disease (2012)	0.1	0.1	0.2	0.3	-0.2	-0.5
Mean Putamen Volume	0.7	0.8	0.8	0.8	0.9	0.9
Fasting Glucose	0.5	0.6	1.7	1.3	0.2	-0.3
HbA1C	0.8	0.9	1.4	-0.3	-1.0	-1.2
HDL Cholesterol	0.1	0.2	0.6	0.1	0.3	0.8
LDL Cholesterol	1.2	1.9	2.4	0.9	1.6	1.6
Lupus	0.4	0.6	1.4	-0.3	0.6	1.2
Neuroticism (2016)	2.4	3.5	4.3	-2.1	-1.5	-2.0
Primary Biliary Cirrhosis	1.4	1.9	2.8	-1.7	-1.2	-1.3
Rheumatoid Arthritis	0.4	0.6	0.8	0.9	0.8	-0.5
Schizophrenia (2014)	1.2	2.7	5.3	-2.3	-1.6	-0.6
Triglycerides	0.1	0.2	0.3	0.3	-0.5	0.5
Type 2 Diabetes (T2D) (2012)	1.8	2.1	3.0	1.1	1.4	1.7
Ulcerative Colitis	0.3	0.5	0.6	-0.5	-0.7	-0.8
Blood Eosinophil Count	0.3	2.1	6.1	-0.6	0.1	-2.5
Blood Platelet Count	0.3	3.3	9.5	0.4	0.3	-3.1
Blood Red Count	0.1	0.9	1.2	-1.0	0.7	1.1
Blood White Count	4.1	30.5	54.6	7.4	6.0	-0.6
Heel T-Score	2.1	16.5	20.5	-4.5	-3.8	-3.8
BMI	0.0	0.1	0.2	0.4	0.4	0.2
Height	0.9	17.0	24.9	-3.7	-5.0	-3.5
Waist Hip Ratio (WHR)	1.3	6.1	10.4	-2.2	-3.2	-1.7
Systolic Blood Pressure	2.6	13.1	31.6	-1.0	-2.6	-5.6
Smoking Status	2.1	5.1	10.1	1.8	1.4	-3.2
Allergy or Eczema	2.1	5.4	9.9	-2.4	-3.1	0.8
Cardiovascular Disease	2.0	6.5	12.0	-1.0	-2.6	-3.5
Hypothyroidism (self reported)	0.0	0.1	0.2	0.0	-0.0	-0.4
Respiratory disease	1.3	2.9	4.3	-2.1	-2.0	-0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	-0.9	-0.7	0.0
Lung FEV1/FVC ratio	0.1	0.6	1.1	-0.5	1.0	0.7
Lung FVC	0.6	3.3	5.0	2.2	2.2	0.1
Neuroticism	5.0	12.1	15.5	-3.5	-3.9	-2.9
Chronotype (morning person)	0.4	0.8	0.9	0.8	0.9	-1.0
Hair Pigment	0.6	17.4	33.6	2.1	3.8	5.8
Tanning	0.6	7.6	21.1	0.3	1.2	4.6
Hand grip strength (left)	2.6	7.0	15.6	2.2	4.0	-0.7
Number of treatments/medications taken	1.4	2.5	4.6	-1.4	-2.1	-0.9
Average weekly spirits intake	0.5	0.6	1.6	1.2	-0.0	0.5
Sensitivity / hurt feelings	0.6	1.1	1.9	-0.4	-1.1	-1.4
Frequency of depressed mood in last 2 weeks	1.6	2.3	4.0	-1.4	-2.0	-0.9
Hearing difficulty/problems: Yes	0.4	0.7	0.8	-0.9	-0.8	0.8
Relative age of first facial hair	1.2	2.4	3.7	1.2	1.9	1.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.9	0.2	-0.2	0.9
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	0.4	-0.8	0.2
Ever had hysterectomy (womb removed)	0.8	0.9	1.6	0.7	1.2	-0.8
Systolic blood pressure, automated reading	0.7	2.1	5.5	0.3	-0.7	-2.4
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.6	1.2	1.3	0.1
Angina	0.8	1.0	1.3	-0.8	-1.1	-1.1
Medication for hormone replacement therapy	0.2	0.2	0.3	0.6	-0.0	0.6
Vitamin and mineral supplements	0.7	1.0	1.5	1.2	-0.6	-1.1
Supplements: Zinc	0.8	0.8	1.3	-1.1	-1.1	-0.2
Medication: Co-codamol	0.7	0.8	1.4	-1.2	-0.9	0.3
Medication: Metformin	0.2	0.2	0.6	0.2	-0.3	0.8
Diabetes (father)	0.2	0.2	0.5	0.1	0.5	-0.7
Diabetes (mother)	2.1	2.7	4.9	-1.8	0.4	2.2
Severe depression (siblings)	2.5	2.8	4.4	-1.4	-2.1	-1.4
Pack years adult smoking proportion	0.7	1.1	2.5	0.8	1.6	0.4
Impedance of leg (right)	2.6	12.7	19.7	-2.7	-4.4	-3.3
Leg fat-free mass (left)	0.2	0.9	2.5	0.2	1.6	-0.4
Trunk fat percentage	0.2	0.9	1.7	-0.9	-0.2	-1.3
Hand grip strength (right)	1.3	3.6	7.1	1.9	2.7	-0.3
Townsend deprivation index at recruitment	0.4	0.5	0.9	-0.7	-0.4	-1.0
Current tobacco smoking	2.4	3.9	7.7	1.6	2.8	-1.2
Average weekly fortified wine intake	0.3	0.4	0.6	0.7	0.2	0.7
Maternal smoking around birth	1.5	2.2	3.8	1.6	1.9	-0.1
Fed-up feelings	1.6	3.0	4.2	-1.6	-1.5	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.9	-0.9	-0.5	-0.7
Relative age voice broke	0.7	1.1	2.7	0.6	0.6	1.6
Taking other prescription medications	0.7	1.1	1.6	-1.2	-1.3	-0.3
Age when periods started (menarche)	0.2	0.5	0.8	-0.7	0.5	0.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.0	-1.0	-0.5	0.9
Heel bone mineral density (BMD) T-score, automated (left)	3.8	8.6	11.0	-3.0	-3.3	-2.3
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	2.0	1.1	1.4	-0.7
Qualifications: CSEs or equivalent	1.0	1.4	2.0	-1.4	-1.1	-0.9
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.3	-0.1	-0.1
High blood pressure	0.5	1.5	2.1	-0.6	-1.5	-1.4
Hayfever, allergic rhinitis or eczema	1.2	2.7	3.9	-2.0	-1.9	0.6
Multivitamins +/- minerals	0.7	0.8	1.1	-0.6	1.1	1.0
Stomach or abdominal pain in last month	0.7	0.9	1.4	-1.2	-1.0	-0.5
Supplements: Glucosamine	0.5	0.7	1.6	0.6	1.3	-0.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.4	-0.6	0.5	0.7
Medication: Atenolol	1.0	1.3	3.0	-0.7	-0.6	-1.7
Medication: Levothyroxine sodium	0.7	1.2	1.6	-1.3	-1.1	-1.0
Sitting height	0.9	6.7	9.2	-3.0	-2.4	-2.3
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	0.3	0.8	-0.3
High blood pressure (mother)	0.1	0.1	0.4	0.6	0.0	-0.2
Body mass index (BMI)	0.5	2.0	3.6	1.1	1.9	1.1
Impedance of leg (left)	2.7	13.2	20.0	-2.9	-4.5	-3.4
Leg predicted mass (left)	0.2	0.8	2.3	0.1	1.5	-0.5
Trunk fat mass	0.2	0.7	1.6	-0.6	0.1	-1.2
Waist circumference	0.0	0.0	0.0	0.1	0.1	-0.2
Number of incorrect matches in round	0.2	0.3	0.8	0.4	-0.9	-0.3
Past tobacco smoking	0.6	1.0	2.8	0.1	0.5	1.7
Alcohol usually taken with meals	1.0	1.6	3.8	-1.0	-1.9	0.3
Nervous feelings	2.3	4.3	10.0	-1.5	-3.2	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	4.4	-1.7	-2.1	-1.0
Hearing difficulty/problems with background noise	1.7	2.7	4.0	-2.0	-1.5	-1.4
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	-0.5	-0.8	0.2
Had menopause	0.1	0.1	0.3	0.3	0.5	0.2
Had other major operations	0.7	0.8	2.1	-0.6	-0.1	1.5
Forced vital capacity (FVC)	0.4	1.4	3.3	-0.9	0.5	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	3.6	8.3	11.2	-3.1	-3.4	-2.0
Ever unenthusiastic/disinterested for a whole week	3.4	4.2	5.7	-1.6	-2.1	-2.4
Qualifications: None of the above	0.1	0.2	0.3	-0.5	-0.2	-0.5
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.1	0.2	-0.6
Mouth/teeth dental problems	0.1	0.1	0.3	-0.1	-0.2	0.6
Heart attack	1.6	2.1	4.9	-0.4	-1.0	-2.2
Allergy	0.7	1.7	2.9	1.7	1.5	-0.3
Pain all over the body in last month	1.9	2.1	4.9	2.2	0.9	0.6
Diabetes (self-reported)	0.2	0.3	0.6	-0.8	0.4	0.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	-1.1	0.1	0.4
Medication: Ramipril	1.9	2.4	3.9	-1.0	-1.6	-2.0
Medication: Simvastatin	0.0	0.1	0.1	0.3	0.0	-0.3
Fluid intelligence score	0.1	0.2	0.5	0.2	-0.7	0.3
Illnesses of siblings	0.1	0.1	0.1	-0.2	0.3	-0.4
Neuroticism score	5.1	10.7	16.2	-3.0	-4.0	-2.7
Weight	0.0	0.2	0.3	-0.4	0.1	-0.6
Impedance of arm (right)	2.0	9.2	11.0	-2.8	-3.0	-3.3
Arm fat percentage (right)	0.1	0.3	0.8	-0.1	0.9	-0.3
Trunk fat-free mass	0.1	0.3	0.6	0.5	0.8	0.4
Hip circumference	0.1	0.5	1.0	0.7	1.0	-0.3
Time employed in main current job	0.8	0.9	1.3	1.1	1.1	0.7
Alcohol intake versus 10 years previously	0.9	1.4	2.2	-1.4	-1.5	-0.0
Father’s age at death	0.7	1.0	1.7	-0.1	1.3	1.1
Worrier / anxious feelings	4.3	8.1	11.6	-3.0	-3.4	-1.8
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	4.2	-1.8	-2.0	0.5
Falls in the last year	0.3	0.4	0.7	-0.4	0.8	-0.7
Hair/balding pattern: Pattern 3	0.8	1.2	1.7	1.3	1.1	-0.8
Number of live births	1.0	1.4	1.6	1.3	1.0	1.3
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.9	-0.7	0.7	-1.4
Pulse rate	0.3	0.5	1.6	1.2	0.1	-0.2
Happiness	1.9	2.3	4.4	0.1	-2.1	-1.6
Noisy workplace	1.2	1.5	3.1	1.7	1.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.9	1.9	5.2	0.7	0.1	2.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.3	-0.4	-0.5	1.5
Mouth/teeth dental problems: Dentures	5.8	9.8	15.8	3.1	4.0	1.9
Asthma	3.4	6.8	10.0	-3.2	-2.8	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.5	0.3	-0.3
Medication: Cholesterol lowering	1.4	2.1	4.5	-1.1	-2.1	-0.9
Depression (self-reported)	1.0	1.2	1.9	-0.0	-1.3	-1.4
Medication: Lansoprazole	0.4	0.5	0.8	-0.9	-0.7	-0.4
Prospective memory result	0.3	0.3	0.9	1.0	0.4	0.1
Lung cancer (father)	2.0	2.3	2.9	1.6	1.7	1.2
Illnesses of mother	0.0	0.0	0.0	0.1	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.1	-0.6	0.1	-1.1
Pulse wave Arterial Stiffness index	0.9	1.0	2.9	0.3	-0.2	-1.7
Impedance of arm (left)	1.5	6.8	9.8	-2.3	-2.3	-3.1
Arm fat mass (right)	0.1	0.4	1.2	0.0	1.1	0.0
Trunk predicted mass	0.1	0.4	0.6	0.5	0.8	0.4
Standing height	1.0	10.3	11.7	-3.0	-3.4	-3.2
Length of working week for main job	2.1	2.3	6.3	-0.4	-0.6	-2.5
Exposure to tobacco smoke at home	0.6	0.7	1.3	-1.1	-0.8	0.1
Breastfed as a baby	1.0	1.2	3.2	1.8	0.7	-0.0
Tense / ‘highly strung’	4.1	6.8	8.7	-2.1	-2.7	-3.0
Seen doctor (GP) for nerves, anxiety, tension or depression	3.2	4.9	9.1	-2.3	-3.0	-0.6
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	0.1	0.1	0.6
Birth weight of first child	0.9	1.7	3.7	0.9	1.9	0.7
Peak expiratory flow (PEF)	0.1	0.2	0.7	-0.0	0.8	0.1
Pulse wave reflection index	0.1	0.1	0.3	-0.0	0.5	0.1
Ever highly irritable/argumentative for 2 days	2.5	3.0	6.9	-1.0	-1.1	-2.6
Loud music exposure frequency	0.7	0.8	2.3	0.2	-0.2	-1.5
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.2	-0.3	-0.0
Mouth/teeth dental problems: Bleeding gums	2.7	3.4	5.6	-2.2	-2.4	0.2
Blood clot in the leg (DVT)	0.2	0.2	0.5	0.7	0.4	0.2
Medication: Paracetamol	0.2	0.3	0.5	0.2	-0.7	0.4
Headache pain in last month	3.1	5.3	10.6	-1.6	-3.3	-1.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.4	0.5	1.6	1.3
Glaucoma (self-reported)	4.7	5.6	6.5	-2.4	-2.5	-2.1
Gout (self-reported)	0.3	0.4	0.5	-0.7	0.5	0.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	-0.5	-0.2	-0.2
Medication: Amlodipine	0.3	0.4	0.8	0.9	0.6	0.4
Medication: Ventolin 100micrograms inhaler	2.5	3.2	6.8	-2.6	-1.6	0.6
Birth weight	0.9	1.9	4.7	0.2	2.2	-0.9
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.2	-0.5	0.5	-0.5
High blood pressure (siblings)	1.0	1.5	2.5	-0.7	-1.6	-1.2
Forced vital capacity (FVC), Best measure	0.2	0.9	2.2	-0.6	-0.2	-1.5
Body fat percentage	0.2	0.8	1.8	-0.7	-0.2	-1.3
Leg fat percentage (right)	0.1	0.3	0.8	-0.1	-0.2	-0.9
Arm fat-free mass (right)	0.1	0.6	1.3	0.8	1.1	-0.1
Exposure to tobacco smoke outside home	1.8	2.4	4.5	1.2	2.1	-1.1
Comparative body size at age 10	0.6	1.6	4.0	0.7	0.6	-2.0
Number of full brothers	1.5	1.9	3.7	1.4	1.9	0.2
Worry too long after embarrassment	3.4	5.7	9.7	-3.1	-2.7	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	4.2	-1.3	-2.0	0.4
Wheeze or whistling in the chest in last year	0.7	1.2	1.5	-1.2	-1.2	-0.8
Number of children fathered	1.5	1.7	3.7	0.5	1.9	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.1	-0.9	-0.6	1.4
Age at first live birth	1.0	1.9	3.8	-1.2	-2.0	0.6
Pulse wave peak to peak time	0.6	0.7	1.9	-0.3	0.1	1.4
Health satisfaction	0.5	0.7	0.9	0.9	-0.6	-0.9
Shortness of breath walking on level ground	2.4	2.8	6.2	-0.7	-1.4	-2.5
Qualifications: College or University degree	0.2	0.7	1.4	-0.6	-0.5	1.2
Eye problems/disorders: None of the above	2.4	2.7	4.9	1.6	2.2	0.9
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	0.2	-0.6	0.4
Emphysema/chronic bronchitis	1.8	2.1	2.4	1.6	1.5	-1.2
Medication for pain relief, constipation, heartburn	0.7	1.2	1.7	0.9	1.0	1.3
Neck or shoulder pain in last month	3.9	5.6	13.1	-3.6	-1.4	-1.3
Medication: Blood pressure	1.0	1.7	3.1	-0.2	-1.4	-1.7
Angina (self-reported)	0.6	0.8	1.1	-0.9	-1.1	-0.8
Migraine (self-reported)	0.4	0.5	1.0	-0.5	1.0	-0.5
Medication: Ibuprofen	0.5	0.6	0.9	0.9	0.7	-0.7
Medication: Allopurinol	0.7	0.9	2.5	-0.3	0.2	1.6
Medication: Omeprazole	1.7	2.0	3.2	-1.6	-1.8	-0.6
Medication: Seretide 50 evohaler	0.9	1.1	1.8	-0.5	-1.3	-1.0
Mean time to correctly identify matches	1.4	2.7	5.8	0.5	-1.4	-2.4
Heart disease (mother)	0.2	0.3	0.7	0.2	-0.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	3.0	0.3	0.1	1.7
Whole body fat mass	0.1	0.5	1.1	-0.5	0.2	-1.1
Leg fat mass (right)	0.1	0.3	0.9	0.1	0.1	-0.9
Arm predicted mass (right)	0.1	0.6	1.1	0.8	1.0	0.2
Pulse rate, automated reading	0.1	0.3	0.5	0.4	0.4	-0.7
Alcohol intake frequency.	1.1	2.6	4.7	-2.2	-1.7	-0.5
Comparative height size at age 10	1.5	8.4	12.7	-2.2	-2.7	-3.6
Number of full sisters	0.3	0.3	0.6	-0.6	-0.8	-0.1
Suffer from ‘nerves’	1.0	1.6	3.2	-1.3	-1.8	0.0
Overall health rating	0.6	1.2	2.2	-0.9	-0.8	-1.5
Chest pain or discomfort	0.1	0.1	0.2	0.4	0.1	0.2
Had major operations	0.3	0.3	1.0	-1.0	-0.3	-0.2
Age at last live birth	0.2	0.3	0.6	-0.7	-0.8	-0.1
Family relationship satisfaction	0.5	0.6	1.6	1.3	0.5	-0.3
Leg pain on walking	1.2	1.6	3.8	1.9	0.9	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.9	1.0	0.7	-0.6
Commuting to job workplace: Car/motor vehicle	3.2	3.7	5.7	1.3	2.4	1.9
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.5	0.6	1.2	-0.6
Medication: Aspirin	0.4	0.5	0.7	-0.5	-0.7	-0.8
Supplements: Vitamin C	1.3	1.5	2.1	-1.4	-1.3	0.8
Knee pain experienced in last month	0.2	0.3	0.8	-0.1	-0.0	-0.9
Hypertension (Self-reported)	0.5	1.5	2.6	-0.3	-1.3	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	5.3	-1.1	-2.3	-1.3
Illnesses of father: Heart disease	2.4	3.3	3.8	-1.6	-1.9	-1.9
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.7	-0.3	-0.0
Smoking status: Previous	0.9	1.3	3.2	0.2	-0.8	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.9	6.6	-1.7	-1.5	-2.6
Whole body fat-free mass	0.1	0.5	1.3	0.4	1.1	0.1
Leg fat-free mass (right)	0.2	0.9	2.6	0.1	1.6	-0.3
Arm fat percentage (left)	0.1	0.5	1.3	0.2	1.2	-0.3
Average weekly red wine intake	0.4	0.5	1.0	0.6	0.4	1.0
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.8	0.8	1.4	0.8
Mood swings	0.5	1.0	1.3	-0.6	-1.1	-1.1
Loneliness, isolation	0.7	1.0	1.5	-1.1	-1.2	-0.4
Long-standing illness, disability or infirmity	0.4	0.7	1.6	-1.3	-0.3	0.6
Ever had bowel cancer screening	0.5	0.5	0.8	0.9	-0.0	0.9
Diabetes diagnosed by doctor	0.3	0.4	0.9	-0.6	-0.1	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.8	-0.5	-1.4	-0.8
Friendships satisfaction	1.1	1.3	3.4	0.4	-0.6	-1.8
Qualifications: nursing, teaching	0.4	0.6	1.9	0.1	-0.2	1.4
Commuting to job workplace: Walk	1.4	1.5	2.7	1.1	-0.7	1.7
Eye problems/disorders: Cataract	3.5	4.0	6.1	-1.9	-2.5	-1.5
Mouth/teeth dental problems: Mouth ulcers	2.6	4.1	6.0	-1.2	-2.2	-2.5
Medication for cholesterol	0.3	0.4	0.7	-0.9	-0.8	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	0.2	0.7	-0.1
Back pain experienced in last month	0.9	1.3	3.2	-1.8	-0.8	0.1
Mineral and other dietary supplements	0.6	0.8	1.6	0.9	1.3	0.2
Breast cancer (self-reported)	2.3	2.7	5.1	2.3	1.8	-0.2
Asthma (self-reported)	3.4	6.8	10.8	-3.3	-2.6	-1.7
Osteoporosis (self-reported)	0.7	0.9	1.6	-0.2	-1.3	0.9
Osteoarthritis (self-reported)	0.6	0.8	1.9	-1.4	-0.6	-0.3
Medication: Aspirin	0.4	0.5	0.6	-0.5	-0.7	-0.8
Medication: Gliclazide	0.3	0.3	0.3	0.5	0.6	0.6
Illnesses of father: None of the above (group 1)	0.3	0.4	1.1	0.0	0.3	1.0
Smoking status: Current	2.1	3.3	6.1	1.2	2.5	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.4	0.1	-0.1	-1.2
Whole body water mass	0.1	0.5	1.2	0.4	1.1	0.1
Leg predicted mass (right)	0.2	0.9	2.5	0.0	1.6	-0.4
Arm fat mass (left)	0.1	0.5	1.3	0.2	1.2	0.0
Number of self-reported non-cancer illnesses	0.4	0.7	1.4	-1.2	-0.9	-0.0
Average weekly champagne plus white wine intake	0.2	0.2	0.4	-0.6	-0.4	-0.3
Miserableness	2.0	3.4	5.6	-1.5	-2.4	-1.5
Guilty feelings	3.2	4.8	5.8	-2.2	-2.4	-2.0
Wears glasses or contact lenses	0.2	0.3	0.5	-0.2	-0.7	0.5
Ever taken oral contraceptive pill	1.0	1.1	1.7	-0.5	-1.2	-1.3
Hearing aid user	0.6	0.7	1.8	-1.4	-0.4	-0.2
Mother’s age at death	2.7	3.4	6.7	-1.8	-2.6	-0.7
Financial situation satisfaction	0.3	0.4	0.6	0.8	-0.5	-0.6
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.0	-0.8	-1.1	-1.7
Commuting to job workplace: Public transport	3.4	4.0	5.2	-1.6	-2.1	-2.3
Eye problems/disorders: Glaucoma	4.6	5.5	6.1	-2.5	-2.4	-2.2
Medication: Blood pressure	0.1	0.2	0.4	-0.3	-0.1	-0.6
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.3	-1.4	0.1	1.5
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.7	-1.4	-1.6	-0.4
High cholesterol (Self-reported)	0.5	0.9	2.0	-0.4	-1.4	-0.8
Medication: Bendroflumethiazide	0.3	0.4	1.1	0.3	-0.0	-1.1
Medication: Paracetamol	0.2	0.2	0.4	0.6	-0.3	0.5
Medication: Lisinopril	0.1	0.1	0.2	-0.1	-0.0	0.5
Medication: Atorvastatin	0.9	1.2	2.2	-0.6	-1.5	-1.0
Illnesses of father: High blood pressure	1.8	2.2	5.3	1.1	-0.3	-2.3
Alcohol drinker status: Never	0.2	0.2	0.3	-0.4	-0.6	-0.5
Ever smoked	0.3	0.5	0.7	0.7	0.5	-0.8
Basal metabolic rate	0.1	0.3	0.9	0.1	1.0	-0.1
Leg fat percentage (left)	0.0	0.1	0.4	-0.1	0.0	-0.6
Arm fat-free mass (left)	0.0	0.2	0.3	0.2	0.6	0.3
Number of operations (self-reported)	0.3	0.4	0.6	-0.8	-0.1	0.8
Average weekly beer plus cider intake	1.8	2.7	7.4	0.6	-0.5	-2.7
Irritability	2.9	4.9	8.7	-1.2	-2.1	-2.9
Risk taking	0.3	0.5	1.3	-1.2	0.0	-0.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.7	-1.3	-1.1	0.4
Fractured/broken bones in last 5 years	0.3	0.4	0.7	-0.7	0.8	-0.2
Age started oral contraceptive pill	2.5	3.2	8.4	0.7	0.8	2.9
Diastolic blood pressure, automated reading	1.1	3.5	6.5	2.5	-0.2	-2.0
Ever depressed for a whole week	3.7	4.6	7.8	-1.8	-1.7	-2.8
Unable to work because of sickness or disability	1.4	1.8	2.9	-1.7	-1.5	-0.5
Commuting to job workplace: Cycle	0.3	0.3	0.8	-0.3	-0.2	-0.9
Myopia	0.7	1.0	2.8	0.2	-1.7	0.1
Vascular/heart problems diagnosed by doctor	1.0	2.6	4.0	1.1	2.0	1.6
Cholesterol lowering medication	0.7	1.0	1.6	1.3	1.0	0.6
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	-1.1	-0.6	-0.0
Pain experienced in last month	1.3	2.2	3.1	1.7	1.8	0.8
Supplements: Calcium	0.4	0.4	0.5	0.7	0.5	-0.6
Basal cell carcinoma (self-reported)	0.5	0.6	1.7	-1.3	-0.2	0.2
Heart attack/myocardial infarction (self-reported)	1.9	2.4	5.9	-0.4	-1.1	-2.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	1.1	0.5	0.2
Heart disease (siblings)	3.1	3.8	9.6	-0.3	1.3	3.1
Alcohol drinker status: Previous	0.6	0.7	1.7	-1.3	-0.0	0.6
Pack years of smoking	1.3	1.9	3.2	1.3	1.8	0.9
Impedance of whole body	2.3	11.8	14.1	-3.0	-3.8	-3.5
Leg fat mass (left)	0.0	0.2	0.5	-0.0	0.3	-0.7
Arm predicted mass (left)	0.0	0.2	0.5	0.3	0.7	0.3