Hub : Genes

RP5-1142A6.2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Hippocampus 0.553 0.134 0.0019 -0.007 NA 0.006 NA -0.012 5.0e-01 NA 0.22000 NA 8.1e-01
2 GTEx Testis 0.213 0.068 0.0022 0.127 NA 0.067 NA 0.117 3.1e-06 NA 0.00066 NA 7.2e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 2.0 3.2 3.9 1.6 -2.0
Bipolar Disorder or Schizophrenia 1.1 2.8 3.4 1.8 -1.5
Depressed Affect (Nagel 2018) 0.1 0.1 0.2 0.2 -0.5
Depression (Nagel 2018) 0.1 0.1 0.1 -0.3 -0.3
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.5 -0.4 0.7
Neuroticism (Nagel 2018) 0.5 1.1 2.0 0.4 -1.4
Schizophrenia (2018) 0.4 0.7 1.4 1.2 -0.3
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 0.0 0.0
Worry (Nagel 2018) 0.8 1.6 3.1 0.4 -1.8
Alzheimer’s Disease (in mother) 0.3 0.4 0.6 -0.7 -0.4
Alzheimer’s Disease (in father) 0.1 0.1 0.2 0.1 0.5
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 -0.5 0.1
Crohns Disease (2017) 0.1 0.2 0.2 0.4 -0.5
Irritable Bowel Disease (IBD) 0.4 1.1 2.0 -0.3 -1.4
Ulcerative Colitis (UC) 0.4 0.7 1.2 -0.5 -1.1
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.3 0.6 0.7 0.8 -0.7
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.0 -1.0 0.6
Breast Cancer 0.5 1.3 2.6 -1.6 0.1
Ovarian Cancer 0.1 0.2 0.3 -0.6 -0.1
Prostate Cancer 0.1 0.2 0.3 -0.3 0.5
Age at First Birth 0.3 0.5 0.9 0.4 0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.5 2.0 3.1 -1.0 1.8
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.0 0.0 0.0 0.0 0.0
Mean Putamen Volume 1.1 1.2 2.2 -0.5 -1.5
Fasting Glucose 0.4 0.5 1.0 -0.1 1.0
HbA1C 0.9 1.0 1.9 -0.0 -1.4
HDL Cholesterol 0.5 0.8 1.4 1.2 0.5
LDL Cholesterol 0.1 0.2 0.2 -0.4 -0.5
Lupus 0.0 0.0 0.1 -0.1 0.3
Neuroticism (2016) 1.0 1.4 2.0 1.4 -0.9
Primary Biliary Cirrhosis 0.7 1.0 1.4 1.2 -0.8
Rheumatoid Arthritis 0.4 0.6 0.6 0.7 0.8
Schizophrenia (2014) 1.1 2.4 4.8 2.2 -0.2
Triglycerides 0.6 1.0 1.7 -1.3 0.5
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.7 1.0 2.1 -0.1 -1.4
Blood Eosinophil Count 0.4 3.4 4.0 1.7 -2.0
Blood Platelet Count 1.1 12.7 25.1 0.5 -5.0
Blood Red Count 0.4 4.2 8.5 0.1 2.9
Blood White Count 0.2 1.3 1.9 0.8 1.4
Heel T-Score 0.9 7.0 13.0 1.0 -3.6
BMI 0.2 0.9 1.4 0.6 -1.2
Height 4.0 77.0 153.8 -0.5 -12.4
Waist Hip Ratio (WHR) 0.5 2.4 4.4 0.6 -2.1
Systolic Blood Pressure 0.5 2.6 4.0 -2.0 1.1
Smoking Status 0.1 0.3 0.6 0.0 0.8
Allergy or Eczema 0.3 0.9 0.9 -0.9 1.0
Cardiovascular Disease 0.8 2.6 4.8 -2.2 -0.6
Hypothyroidism (self reported) 1.4 3.2 5.9 2.4 -0.6
Respiratory disease 2.4 5.3 6.9 -2.6 -1.9
Type 2 Diabetes (T2D) (2018) 1.0 1.8 3.3 -0.5 -1.8
Lung FEV1/FVC ratio 1.9 9.7 15.6 3.9 -1.9
Lung FVC 2.1 10.7 20.3 -1.0 4.5
Neuroticism 0.6 1.5 2.9 0.4 -1.7
Chronotype (morning person) 0.9 2.0 2.5 -1.6 1.2
Hair Pigment 4.3 122.9 171.6 -8.6 13.1
Tanning 0.6 7.6 10.8 2.1 -3.3
Hand grip strength (left) 2.3 6.1 9.7 3.1 -1.6
Number of treatments/medications taken 0.4 0.7 1.3 -0.2 -1.1
Average weekly spirits intake 2.4 3.0 5.3 0.9 -2.3
Sensitivity / hurt feelings 0.1 0.2 0.4 0.6 -0.2
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.7 0.1 -1.3
Hearing difficulty/problems: Yes 0.1 0.1 0.1 -0.3 0.3
Relative age of first facial hair 0.5 0.9 1.2 -0.8 1.1
Other serious medical condition/disability diagnosed by doctor 1.7 2.2 4.3 -0.4 -2.1
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 -0.1 -0.7
Ever had hysterectomy (womb removed) 1.1 1.2 1.2 -1.1 -1.1
Systolic blood pressure, automated reading 1.0 3.0 3.4 -1.6 1.8
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.2 -0.1 -1.5
Angina 0.1 0.1 0.1 0.3 0.2
Medication for hormone replacement therapy 1.2 1.3 2.2 0.6 -1.5
Vitamin and mineral supplements 0.2 0.3 0.7 0.1 0.8
Supplements: Zinc 0.9 1.0 1.7 -0.6 -1.3
Medication: Co-codamol 0.6 0.7 1.5 1.2 -0.0
Medication: Metformin 0.0 0.0 0.1 -0.3 0.1
Diabetes (father) 0.1 0.1 0.2 0.5 0.1
Diabetes (mother) 2.3 3.0 3.3 -1.8 1.6
Severe depression (siblings) 0.9 1.0 1.7 -1.3 -0.6
Pack years adult smoking proportion 0.1 0.1 0.1 0.1 -0.4
Impedance of leg (right) 1.9 9.0 14.2 3.8 -2.0
Leg fat-free mass (left) 1.9 10.2 20.0 -0.6 -4.5
Trunk fat percentage 1.0 4.0 6.3 2.5 -1.3
Hand grip strength (right) 1.2 3.4 5.1 2.3 -1.3
Townsend deprivation index at recruitment 0.1 0.1 0.1 -0.4 0.2
Current tobacco smoking 0.1 0.2 0.3 -0.4 -0.6
Average weekly fortified wine intake 0.2 0.2 0.4 0.6 -0.2
Maternal smoking around birth 0.3 0.4 0.8 0.9 -0.3
Fed-up feelings 0.5 1.0 1.3 1.2 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 2.6 -0.3 -1.6
Relative age voice broke 0.4 0.6 0.7 -0.9 0.6
Taking other prescription medications 0.1 0.2 0.2 -0.5 -0.3
Age when periods started (menarche) 0.5 1.2 1.7 0.8 1.3
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.4 -1.2 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.3 -0.1 -1.1
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.3 0.3 0.5
Qualifications: CSEs or equivalent 2.1 2.8 3.6 1.9 1.4
Serious illness, injury or assault to yourself 0.2 0.2 0.3 0.6 -0.2
High blood pressure 2.7 7.6 14.4 -3.8 0.8
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.2 -0.3 0.5
Multivitamins +/- minerals 0.6 0.8 1.4 0.4 -1.2
Stomach or abdominal pain in last month 2.0 2.5 4.8 -0.4 -2.2
Supplements: Glucosamine 1.1 1.4 2.5 1.6 0.5
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 1.5 0.5 -1.2
Medication: Atenolol 4.1 5.1 6.8 -2.6 1.8
Medication: Levothyroxine sodium 1.1 1.8 2.9 1.7 -0.8
Sitting height 1.6 11.5 16.8 -2.5 -4.1
Chronic bronchitis/emphysema (father) 1.3 1.5 2.7 -0.5 1.7
High blood pressure (mother) 1.8 2.5 4.1 -2.0 1.0
Body mass index (BMI) 0.1 0.6 0.8 0.9 -0.6
Impedance of leg (left) 2.0 9.9 16.2 4.0 -1.9
Leg predicted mass (left) 1.9 10.0 19.8 -0.5 -4.5
Trunk fat mass 1.6 7.0 9.2 2.2 -3.0
Waist circumference 1.3 4.8 8.7 1.0 -3.0
Number of incorrect matches in round 0.3 0.6 0.8 0.9 0.6
Past tobacco smoking 0.9 1.6 2.7 -0.7 -1.6
Alcohol usually taken with meals 1.0 1.6 2.8 1.7 -0.6
Nervous feelings 2.3 4.4 7.5 1.1 -2.7
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 0.8 -0.9 -0.1
Hearing difficulty/problems with background noise 0.7 1.2 1.2 -1.1 1.1
Hair/balding pattern: Pattern 2 0.1 0.1 0.3 0.0 0.5
Had menopause 0.1 0.2 0.2 0.3 -0.5
Had other major operations 0.4 0.4 0.9 -0.9 -0.1
Forced vital capacity (FVC) 0.3 1.1 2.2 0.3 -1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.2 -0.1 -1.5
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 1.5 1.2 -0.9
Qualifications: None of the above 0.7 1.5 1.6 1.3 1.2
Financial difficulties in last 2 years 0.3 0.4 0.8 -0.2 0.9
Mouth/teeth dental problems 1.1 1.7 2.2 1.5 1.1
Heart attack 6.6 8.4 14.4 -3.8 1.5
Allergy 0.2 0.4 0.6 0.8 -0.3
Pain all over the body in last month 1.0 1.1 2.2 -0.2 1.5
Diabetes (self-reported) 0.3 0.4 0.7 -0.8 -0.2
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 2.3 0.7 -1.5
Medication: Ramipril 0.4 0.5 0.8 -0.9 0.5
Medication: Simvastatin 0.5 0.7 1.3 -1.2 0.1
Fluid intelligence score 0.3 0.6 1.1 1.1 0.2
Illnesses of siblings 0.4 0.6 1.2 1.1 -0.1
Neuroticism score 1.6 3.3 4.8 1.3 -2.2
Weight 2.3 11.2 21.5 0.9 -4.6
Impedance of arm (right) 0.5 2.2 4.2 0.5 2.0
Arm fat percentage (right) 0.3 1.2 2.4 1.6 0.2
Trunk fat-free mass 4.6 26.3 52.6 -0.1 -7.2
Hip circumference 1.2 5.1 8.2 1.4 -2.9
Time employed in main current job 0.5 0.6 0.9 -1.0 0.5
Alcohol intake versus 10 years previously 0.2 0.3 0.5 -0.3 0.7
Father’s age at death 1.4 1.9 3.7 -0.4 -1.9
Worrier / anxious feelings 1.0 2.0 3.8 0.3 -2.0
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.2 0.4 -1.1
Falls in the last year 0.8 1.1 1.2 1.0 -1.1
Hair/balding pattern: Pattern 3 2.0 3.0 5.9 2.4 0.0
Number of live births 0.4 0.6 0.9 -0.5 -1.0
Forced expiratory volume in 1-second (FEV1) 0.8 2.7 2.7 1.7 -1.7
Pulse rate 1.8 3.0 3.4 -1.9 -1.6
Happiness 2.2 2.7 3.3 1.4 -1.8
Noisy workplace 3.1 3.8 7.3 0.5 2.7
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.4 0.7 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.1 -0.3 -0.3
Mouth/teeth dental problems: Dentures 1.4 2.3 3.3 -1.8 1.1
Asthma 1.0 1.9 2.8 -1.7 -1.0
Medication: Ibuprofen (e.g. Nurofen) 6.7 8.5 11.0 3.3 -2.5
Medication: Cholesterol lowering 0.3 0.5 0.7 -0.9 0.5
Depression (self-reported) 0.6 0.7 1.0 1.0 -0.6
Medication: Lansoprazole 0.3 0.4 0.5 -0.5 -0.7
Prospective memory result 0.1 0.1 0.3 -0.0 -0.5
Lung cancer (father) 0.8 1.0 1.1 1.1 0.9
Illnesses of mother 3.2 4.0 7.0 2.6 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 2.5 1.6 -1.2
Pulse wave Arterial Stiffness index 0.3 0.4 0.6 -0.4 -0.8
Impedance of arm (left) 0.5 2.4 4.4 0.6 2.1
Arm fat mass (right) 0.6 2.5 3.8 1.1 -1.9
Trunk predicted mass 4.5 25.5 51.0 -0.2 -7.1
Standing height 4.2 41.4 82.8 0.2 -9.1
Length of working week for main job 0.7 0.8 1.5 0.4 -1.2
Exposure to tobacco smoke at home 0.2 0.2 0.3 -0.6 0.1
Breastfed as a baby 0.3 0.4 0.7 0.8 0.2
Tense / ‘highly strung’ 0.3 0.6 1.1 0.2 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.1 0.1 0.3 -0.1
Hair/balding pattern: Pattern 4 0.2 0.5 1.0 1.0 0.0
Birth weight of first child 1.7 3.2 3.6 -1.9 -1.7
Peak expiratory flow (PEF) 0.7 1.7 3.2 1.8 0.4
Pulse wave reflection index 0.5 0.6 1.2 0.3 1.1
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.4 0.6 0.1
Loud music exposure frequency 0.3 0.3 0.6 0.7 -0.1
Qualifications: O levels/GCSEs or equivalent 0.7 1.2 2.1 0.6 -1.4
Mouth/teeth dental problems: Bleeding gums 1.8 2.4 4.0 -0.9 -2.0
Blood clot in the leg (DVT) 1.6 2.0 2.4 -1.5 1.3
Medication: Paracetamol 1.7 2.8 4.5 1.0 -2.1
Headache pain in last month 0.2 0.3 0.5 -0.4 -0.7
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 3.0 1.7 0.3
Glaucoma (self-reported) 0.1 0.1 0.3 0.5 -0.0
Gout (self-reported) 1.7 2.3 4.4 -2.1 -0.4
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 3.5 1.9 -1.0
Medication: Amlodipine 1.3 1.9 3.4 -1.9 -0.6
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.8 -0.9 0.1
Birth weight 1.5 3.3 3.8 -2.0 -1.7
Chronic bronchitis/emphysema (mother) 0.0 0.0 0.0 0.1 0.1
High blood pressure (siblings) 1.5 2.2 4.4 -2.1 0.0
Forced vital capacity (FVC), Best measure 0.2 0.9 1.7 0.3 -1.3
Body fat percentage 1.2 4.7 7.8 2.8 -1.2
Leg fat percentage (right) 2.0 7.1 11.2 3.3 -1.8
Arm fat-free mass (right) 4.3 22.1 44.2 0.2 -6.7
Exposure to tobacco smoke outside home 1.8 2.4 2.6 1.6 1.5
Comparative body size at age 10 0.5 1.5 1.9 1.4 -1.1
Number of full brothers 0.4 0.5 0.5 0.7 0.7
Worry too long after embarrassment 1.0 1.7 3.3 0.4 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 0.7 -0.1 -0.8
Wheeze or whistling in the chest in last year 1.8 3.3 6.5 -0.4 -2.5
Number of children fathered 0.5 0.6 1.1 -0.4 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.7 0.2 0.8
Age at first live birth 0.4 0.6 1.2 1.1 0.1
Pulse wave peak to peak time 0.1 0.1 0.3 0.5 -0.1
Health satisfaction 0.0 0.0 0.0 0.0 0.1
Shortness of breath walking on level ground 2.1 2.5 5.1 -2.2 0.1
Qualifications: College or University degree 0.5 1.5 2.7 -0.6 -1.6
Eye problems/disorders: None of the above 0.5 0.5 0.8 0.5 0.9
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.4 -0.6 -0.6
Emphysema/chronic bronchitis 0.1 0.1 0.3 -0.0 0.5
Medication for pain relief, constipation, heartburn 1.2 2.1 2.4 -1.5 1.4
Neck or shoulder pain in last month 0.1 0.1 0.1 0.4 -0.3
Medication: Blood pressure 3.0 5.3 10.5 -3.2 0.3
Angina (self-reported) 0.1 0.2 0.2 0.5 0.4
Migraine (self-reported) 1.0 1.2 2.2 -1.5 -0.5
Medication: Ibuprofen 5.5 6.6 7.3 2.7 -2.4
Medication: Allopurinol 0.4 0.6 0.9 -0.9 0.6
Medication: Omeprazole 0.5 0.6 1.0 1.0 0.5
Medication: Seretide 50 evohaler 1.9 2.2 4.0 -2.0 -0.6
Mean time to correctly identify matches 0.0 0.1 0.1 -0.3 -0.3
Heart disease (mother) 2.4 2.9 4.8 -2.2 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.5 4.1 6.0 -2.5 1.5
Whole body fat mass 1.3 5.6 7.5 1.9 -2.7
Leg fat mass (right) 1.6 6.3 7.7 2.2 -2.8
Arm predicted mass (right) 4.3 21.8 43.4 0.5 -6.6
Pulse rate, automated reading 1.0 3.2 6.2 -0.4 -2.5
Alcohol intake frequency. 2.3 5.3 7.5 -2.7 1.8
Comparative height size at age 10 3.8 20.8 40.8 0.9 -6.4
Number of full sisters 1.4 1.7 2.0 1.2 1.4
Suffer from ‘nerves’ 1.7 2.7 3.8 1.3 -1.9
Overall health rating 0.3 0.6 0.8 -0.7 -0.9
Chest pain or discomfort 0.1 0.1 0.2 -0.0 -0.5
Had major operations 0.1 0.1 0.1 -0.1 0.3
Age at last live birth 1.0 1.4 1.8 1.4 1.0
Family relationship satisfaction 0.1 0.1 0.1 -0.2 -0.3
Leg pain on walking 1.2 1.6 1.8 -1.2 -1.3
Qualifications: NVQ or HND or HNC or equivalent 1.6 1.9 3.7 -0.2 1.9
Commuting to job workplace: Car/motor vehicle 3.1 3.5 6.1 0.9 2.5
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 -0.2 0.5
Medication: Aspirin 1.5 2.0 3.9 -2.0 0.2
Supplements: Vitamin C 0.4 0.5 0.9 -1.0 -0.3
Knee pain experienced in last month 1.3 2.1 2.9 1.1 -1.7
Hypertension (Self-reported) 3.2 9.0 17.0 -4.1 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.1 -0.3 0.1
Illnesses of father: Heart disease 3.5 4.9 6.2 -2.5 1.9
Illnesses of siblings: Diabetes 0.1 0.2 0.2 0.3 -0.5
Smoking status: Previous 1.2 1.8 3.4 0.3 1.9
Forced expiratory volume in 1-second (FEV1), predicted 3.2 6.6 13.1 -0.1 -3.6
Whole body fat-free mass 3.6 20.9 41.6 -0.3 -6.5
Leg fat-free mass (right) 1.8 9.5 18.3 -0.8 -4.3
Arm fat percentage (left) 0.3 1.3 2.6 1.6 0.2
Average weekly red wine intake 1.1 1.7 2.6 -0.9 -1.6
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.8 -0.0 0.9
Mood swings 0.5 0.9 1.6 -0.4 -1.3
Loneliness, isolation 0.6 0.8 1.5 0.4 1.2
Long-standing illness, disability or infirmity 1.0 1.5 2.9 -0.3 -1.7
Ever had bowel cancer screening 0.8 0.9 1.5 -1.2 -0.5
Diabetes diagnosed by doctor 1.3 2.2 3.5 -1.9 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 1.4 -1.2 0.5
Friendships satisfaction 1.4 1.7 3.1 -1.7 -0.6
Qualifications: nursing, teaching 1.2 1.9 2.8 1.7 1.0
Commuting to job workplace: Walk 1.6 1.7 3.4 0.2 -1.9
Eye problems/disorders: Cataract 0.4 0.4 0.6 -0.5 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.5 -1.2 -0.7
Medication for cholesterol 0.9 1.4 1.9 1.4 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.8 0.9 -0.1
Back pain experienced in last month 3.2 4.6 8.0 1.2 -2.8
Mineral and other dietary supplements 0.1 0.1 0.1 -0.4 0.3
Breast cancer (self-reported) 1.0 1.2 1.5 1.0 -1.2
Asthma (self-reported) 0.7 1.4 2.2 -1.5 -0.8
Osteoporosis (self-reported) 0.9 1.2 1.5 1.2 0.9
Osteoarthritis (self-reported) 0.7 0.9 1.5 1.2 -0.4
Medication: Aspirin 2.1 2.7 5.4 -2.3 -0.1
Medication: Gliclazide 0.6 0.7 0.7 0.8 0.9
Illnesses of father: None of the above (group 1) 3.4 4.2 6.8 2.6 -1.3
Smoking status: Current 0.3 0.5 0.9 -0.2 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 2.8 1.7 0.0
Whole body water mass 3.5 20.1 40.2 -0.3 -6.3
Leg predicted mass (right) 1.8 9.6 18.6 -0.8 -4.3
Arm fat mass (left) 0.7 3.0 3.9 1.4 -2.0
Number of self-reported non-cancer illnesses 0.1 0.2 0.3 -0.5 -0.2
Average weekly champagne plus white wine intake 2.0 2.7 5.3 2.3 0.4
Miserableness 0.1 0.2 0.3 0.3 0.5
Guilty feelings 3.0 4.6 4.8 2.2 -2.1
Wears glasses or contact lenses 0.4 0.4 0.6 -0.8 -0.5
Ever taken oral contraceptive pill 0.7 0.7 1.4 -0.2 -1.2
Hearing aid user 1.1 1.2 2.3 -1.5 0.3
Mother’s age at death 0.4 0.5 0.6 0.8 0.6
Financial situation satisfaction 0.1 0.1 0.1 -0.1 0.4
Tinnitus: Yes, now most or all of the time 1.8 2.2 4.0 -0.6 2.0
Commuting to job workplace: Public transport 3.1 3.7 7.2 -0.4 -2.7
Eye problems/disorders: Glaucoma 0.3 0.3 0.6 0.8 -0.2
Medication: Blood pressure 5.4 10.2 20.4 -4.5 0.2
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.0 1.0 -0.5
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.4 0.6 0.3
High cholesterol (Self-reported) 0.1 0.2 0.3 -0.4 0.6
Medication: Bendroflumethiazide 0.9 1.4 2.1 -1.4 -0.8
Medication: Paracetamol 1.2 1.9 3.6 -0.3 -1.9
Medication: Lisinopril 5.2 6.7 13.4 -3.7 -0.2
Medication: Atorvastatin 0.2 0.2 0.4 0.6 0.1
Illnesses of father: High blood pressure 2.0 2.4 4.8 -2.2 -0.2
Alcohol drinker status: Never 1.2 1.4 2.4 -1.5 0.6
Ever smoked 0.8 1.4 2.1 1.4 0.8
Basal metabolic rate 3.5 19.3 38.7 0.0 -6.2
Leg fat percentage (left) 2.0 7.4 11.9 3.5 -1.7
Arm fat-free mass (left) 4.3 21.9 43.4 0.5 -6.6
Number of operations (self-reported) 0.4 0.5 1.0 -1.0 -0.2
Average weekly beer plus cider intake 0.5 0.7 1.3 -1.1 0.4
Irritability 1.8 3.0 5.9 0.2 -2.4
Risk taking 0.2 0.4 0.5 0.7 -0.5
Ever had prostate specific antigen (PSA) test 2.5 2.9 5.1 -2.3 0.9
Fractured/broken bones in last 5 years 0.5 0.6 1.0 -1.0 0.5
Age started oral contraceptive pill 0.4 0.5 0.8 -0.9 0.5
Diastolic blood pressure, automated reading 0.0 0.0 0.1 0.1 0.2
Ever depressed for a whole week 0.5 0.6 1.1 1.0 -0.2
Unable to work because of sickness or disability 0.3 0.4 0.7 0.8 0.3
Commuting to job workplace: Cycle 3.0 3.6 4.3 -2.1 1.7
Myopia 0.3 0.5 0.8 0.3 -0.9
Vascular/heart problems diagnosed by doctor 2.5 6.8 13.3 3.6 -0.6
Cholesterol lowering medication 0.3 0.5 0.9 0.9 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.2 1.5 -0.1
Pain experienced in last month 1.3 2.2 4.3 -0.4 2.1
Supplements: Calcium 0.1 0.1 0.1 -0.2 0.2
Basal cell carcinoma (self-reported) 0.2 0.3 0.4 0.4 -0.7
Heart attack/myocardial infarction (self-reported) 6.7 8.6 14.9 -3.9 1.5
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 2.1 -1.5 0.8
Heart disease (siblings) 0.3 0.3 0.4 -0.5 0.6
Alcohol drinker status: Previous 3.1 3.5 6.2 -2.5 0.9
Pack years of smoking 0.0 0.0 0.0 0.0 -0.2
Impedance of whole body 0.6 3.0 5.7 2.4 0.6
Leg fat mass (left) 1.9 7.2 8.7 2.4 -3.0
Arm predicted mass (left) 4.7 23.9 47.6 0.4 -6.9