Hub : Genes

RPS6KL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.04 0.023 3.8e-03 0.024 0.019 0.016 0.021 0.025 5.4e-04 2.1e-03 4.1e-03 1.1e-03 4.8e-04
2 GTEx Adipose Subcutaneous 0.09 0.031 3.8e-06 0.118 NA 0.095 NA 0.097 6.9e-10 NA 3.6e-08 NA 2.5e-08
3 GTEx Adipose Visceral Omentum 0.12 0.049 7.0e-05 0.088 NA 0.074 NA 0.085 2.7e-05 NA 1.1e-04 NA 3.7e-05
4 GTEx Adrenal Gland 0.21 0.072 5.9e-06 0.134 NA 0.151 NA 0.143 1.6e-05 NA 4.4e-06 NA 7.9e-06
5 GTEx Artery Aorta 0.16 0.057 5.5e-06 0.053 NA 0.069 NA 0.055 6.6e-04 NA 1.2e-04 NA 5.3e-04
6 GTEx Artery Coronary 0.10 0.043 1.2e-03 0.181 NA 0.105 NA 0.125 1.1e-06 NA 2.2e-04 NA 5.5e-05
7 GTEx Artery Tibial 0.16 0.049 9.1e-08 0.108 NA 0.128 NA 0.134 7.9e-09 NA 3.2e-10 NA 1.1e-10
8 GTEx Cells Transformed fibroblasts 0.16 0.052 7.8e-07 0.150 NA 0.149 NA 0.142 2.3e-11 NA 2.8e-11 NA 8.9e-11
9 GTEx Esophagus Mucosa 0.18 0.056 4.5e-07 0.124 NA 0.090 NA 0.117 1.2e-08 NA 1.4e-06 NA 3.3e-08
10 GTEx Esophagus Muscularis 0.10 0.044 3.5e-04 0.107 NA 0.059 NA 0.092 4.9e-07 NA 1.8e-04 NA 3.1e-06
11 GTEx Lung 0.09 0.038 4.9e-05 0.090 NA 0.076 NA 0.055 2.3e-07 NA 1.8e-06 NA 4.5e-05
12 GTEx Nerve Tibial 0.17 0.044 1.0e-12 0.237 NA 0.169 NA 0.189 8.5e-17 NA 4.8e-12 NA 2.3e-13
13 GTEx Prostate 0.26 0.098 4.3e-04 0.105 NA 0.111 NA 0.171 1.3e-03 NA 1.0e-03 NA 4.6e-05
14 GTEx Skin Not Sun Exposed Suprapubic 0.08 0.033 4.9e-04 0.083 NA 0.067 NA 0.019 2.5e-05 NA 1.5e-04 NA 3.2e-02
15 GTEx Skin Sun Exposed Lower leg 0.15 0.045 2.4e-07 0.128 NA 0.117 NA 0.125 1.0e-10 NA 6.6e-10 NA 1.8e-10
16 GTEx Small Intestine Terminal Ileum 0.57 0.107 3.7e-05 0.120 NA 0.099 NA 0.101 1.3e-03 NA 3.2e-03 NA 2.9e-03
17 GTEx Stomach 0.09 0.045 6.7e-03 -0.006 NA 0.000 NA -0.006 9.0e-01 NA 3.3e-01 NA 8.8e-01
18 GTEx Thyroid 0.23 0.062 9.6e-09 0.144 NA 0.137 NA 0.136 3.9e-11 NA 1.3e-10 NA 1.5e-10
19 GTEx Uterus 0.26 0.137 3.9e-03 0.087 NA 0.107 NA 0.113 8.1e-03 NA 3.5e-03 NA 2.8e-03
20 METSIM Adipose 0.07 0.024 9.2e-08 0.066 0.062 0.062 0.061 0.060 4.4e-10 1.3e-09 1.5e-09 1.7e-09 2.3e-09
21 TCGA Breast Normal 0.04 0.015 1.6e-04 0.017 0.016 0.017 NA 0.016 1.5e-05 2.5e-05 1.6e-05 NA 2.6e-05
22 TCGA Prostate Tumor 0.14 0.043 6.0e-09 0.086 0.070 0.074 NA 0.083 4.1e-11 2.7e-09 1.0e-09 NA 8.9e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Alzheimer’s Disease (in mother) 1.1 1.2 3.7 0.6 -1.0 -1.6 -1.1 -1.6 -0.2 -1.4 -0.9 -1.9 -1.3 -0.7 -1.2 -0.6 -1.2 -1.3 -0.5 -1.2 -1.0 -0.9 -0.3 -1.4 -0.8
Alzheimer’s Disease (in father) 0.2 0.2 1.0 0.7 0.4 -0.3 0.0 0.4 0.3 0.1 -0.0 -0.6 0.4 0.2 0.0 -0.5 -0.4 0.0 0.6 -1.0 0.1 0.4 0.2 0.1 -0.3
Alzheimer’s Disease (including proxy) 1.6 2.3 3.7 1.8 -1.6 -1.6 -1.4 -0.9 -0.1 -1.6 -1.8 -1.2 -1.7 -1.3 -1.6 -1.8 -1.6 -1.9 -1.4 -1.5 -1.7 -1.8 -1.1 -1.4 -1.4
Crohns Disease (2017) 1.8 4.0 9.9 1.3 -2.1 -1.6 -1.9 -1.5 -0.6 -2.5 -2.5 -0.8 -2.0 -1.0 -2.0 -2.8 -1.5 -2.1 -2.5 -1.9 -2.3 -2.1 -2.3 -1.7 -3.1
Irritable Bowel Disease (IBD) 0.8 1.8 5.6 0.3 -1.1 -0.5 -1.7 0.1 1.1 -1.3 -1.6 1.1 -1.3 -0.1 -1.0 -1.8 -1.5 -1.3 -2.4 0.2 -1.1 -1.9 -1.7 -1.5 -1.9
Ulcerative Colitis (UC) 0.5 1.0 5.0 -0.3 -0.3 0.3 -1.1 1.2 2.2 0.0 -0.6 2.1 -0.6 0.3 -0.2 -0.6 -1.1 -0.5 -1.5 1.4 -0.0 -1.2 -0.7 -1.1 -0.6
Major Depression (MDD) 3.7 4.6 14.9 -2.2 2.0 1.4 1.9 1.6 0.4 2.5 2.4 0.8 2.2 1.5 2.0 2.3 3.9 2.5 3.1 1.1 2.0 2.3 1.4 3.0 1.5
Reaction Time 1.1 2.0 9.1 2.2 -0.6 -1.9 -0.7 -1.8 -2.6 0.2 -0.5 -3.0 -0.3 -0.5 -1.2 0.1 -0.8 -0.5 2.1 -2.8 -0.4 0.8 -0.5 -0.5 -0.4
Verbal and Numeric Reasoning (VNR) 0.8 2.0 6.0 1.1 -0.9 -1.2 -2.4 -1.3 -1.9 -1.2 -0.8 -1.3 -0.9 -1.3 -1.2 -1.2 -2.4 -1.2 -1.1 -1.6 -0.4 -0.7 -1.6 -2.0 -1.0
Breast Cancer 0.3 0.8 2.9 -0.5 0.6 0.7 1.0 1.1 1.2 1.0 1.1 -0.1 0.7 -0.0 0.5 0.9 0.3 0.8 0.6 1.2 0.6 1.3 1.7 0.4 0.8
Ovarian Cancer 1.3 1.8 3.5 -0.6 1.5 1.2 0.9 1.4 1.6 1.4 1.6 0.9 1.4 1.3 1.3 1.7 1.6 1.5 1.9 0.2 1.5 1.4 1.1 1.3 1.0
Prostate Cancer 3.9 5.5 8.3 -2.9 2.4 2.5 2.1 2.0 1.4 2.6 2.7 2.1 2.5 2.0 2.5 2.4 2.6 2.7 1.7 2.3 2.4 2.2 2.1 2.3 2.7
Age at First Birth 1.1 1.7 6.7 0.2 -0.3 0.4 -1.0 1.6 2.2 -0.8 -0.8 2.5 -0.6 -0.2 -0.1 -1.6 -2.1 -0.8 -2.6 0.6 -0.2 -1.4 -0.9 -1.6 -0.4
Bipolar Disorder 0.6 0.6 2.5 -0.3 -0.1 -0.2 -1.1 -0.8 -0.9 -0.3 0.3 -0.1 -0.0 -1.4 -0.4 0.0 -1.2 -0.2 -0.3 -1.6 0.2 -0.0 -1.5 -1.0 -0.7
Body Mass Index (BMI) (2010) 1.3 1.8 4.4 -0.6 1.4 0.9 1.7 0.9 0.3 1.4 1.6 -0.0 1.4 1.1 1.1 2.1 1.5 1.6 1.8 -0.8 1.3 1.9 1.0 1.8 1.2
Coronary Artery Disease (CAD) 7.7 9.4 13.6 -3.7 3.3 3.2 2.9 3.5 3.0 3.0 3.0 2.6 3.3 2.4 3.3 3.3 2.9 2.9 1.5 3.0 3.2 2.7 3.1 3.1 3.5
Crohns Disease (2012) 0.5 0.9 4.0 -0.7 0.9 0.8 0.6 1.3 0.7 0.6 0.9 0.8 0.7 -0.1 0.9 1.2 -0.0 0.8 0.3 2.0 1.1 0.6 0.9 0.3 1.7
Mean Putamen Volume 0.3 0.4 0.8 -0.4 0.6 0.6 0.9 -0.0 -0.4 0.5 0.6 -0.3 0.4 0.4 0.6 0.9 0.6 0.8 0.9 -0.6 0.3 0.7 0.7 0.9 0.6
Fasting Glucose 0.4 0.5 3.5 0.6 -0.4 -0.9 -0.4 -0.7 -0.3 0.0 -0.1 -1.9 -0.4 -1.2 -0.5 -0.9 -0.7 -0.5 -0.4 -0.6 -0.2 0.3 0.2 -0.8 -0.5
HbA1C 0.1 0.2 0.5 -0.0 0.3 -0.3 -0.5 -0.3 -0.5 -0.4 0.2 -0.5 0.1 -0.7 -0.1 -0.5 -0.6 0.0 -0.3 -0.4 0.2 0.7 -0.6 -0.4 0.0
HDL Cholesterol 1.0 1.6 6.6 0.9 -0.9 -0.9 -1.4 -0.6 -0.4 -0.9 -1.1 -0.1 -1.2 -1.0 -1.1 -1.4 -2.6 -1.2 -1.6 -0.7 -0.8 -1.1 -1.7 -2.0 -1.2
LDL Cholesterol 2.4 3.8 6.4 2.5 -2.3 -1.9 -1.9 -1.0 -0.7 -2.2 -2.4 -0.8 -2.3 -1.9 -2.1 -1.5 -1.9 -2.3 -1.9 -0.6 -2.4 -2.5 -1.6 -1.9 -2.0
Lupus 0.5 0.7 3.7 -0.5 0.6 0.8 0.6 1.0 1.9 -0.0 0.5 1.7 0.3 -0.3 0.8 0.1 0.4 0.3 0.5 1.7 1.0 -0.3 0.5 0.6 0.9
Neuroticism 4.5 6.7 16.3 -3.7 2.5 2.3 2.1 1.9 0.9 3.1 2.5 2.2 2.5 2.3 2.6 2.3 4.0 2.4 1.2 3.6 2.6 1.9 2.1 3.1 2.8
Primary Biliary Cirrhosis 1.1 1.6 3.8 -1.6 1.1 1.1 0.9 1.5 1.2 1.3 1.5 1.4 1.0 0.7 1.3 1.9 1.1 0.6 0.5 1.3 1.2 0.7 1.6 1.2 1.7
Rheumatoid Arthritis 2.6 3.6 8.4 1.5 -2.0 -1.6 -1.5 -2.2 -2.9 -1.6 -2.1 -1.3 -1.9 -1.1 -1.9 -2.7 -0.9 -1.8 -1.8 -1.1 -2.4 -2.1 -2.6 -1.5 -1.8
Schizophrenia 2.3 5.1 18.2 -4.3 2.5 2.4 2.0 0.6 -0.2 1.5 2.9 2.0 2.3 2.3 2.5 3.1 2.6 2.1 0.6 1.7 2.5 1.7 1.1 2.4 2.3
Triglycerides 2.7 4.4 6.5 -1.5 2.1 2.4 1.8 2.4 1.7 2.4 1.9 1.8 2.3 1.6 2.3 2.2 2.4 2.5 1.7 1.5 2.1 1.9 2.2 2.5 2.3
Type 2 Diabetes (T2D) 0.8 0.9 8.8 0.9 0.4 -0.5 1.1 -0.4 -2.0 -0.5 0.3 -1.4 0.3 0.8 -0.2 -0.2 -0.3 0.4 0.4 -3.0 0.1 1.0 0.0 0.2 -0.1
Ulcerative Colitis 0.4 0.6 1.6 -0.6 0.6 0.1 1.1 -0.5 -0.5 0.2 0.8 -1.2 0.7 0.2 0.6 0.7 1.0 0.6 1.0 -0.7 0.2 1.1 1.3 0.9 0.9
Blood Eosinophil Count 0.8 6.2 12.4 2.4 -2.4 -2.2 -1.9 -1.4 -1.0 -2.5 -2.4 -1.7 -2.6 -2.6 -2.5 -3.0 -3.5 -2.9 -3.1 -2.4 -2.4 -2.2 -2.1 -3.4 -2.8
Blood Platelet Count 2.3 26.8 52.2 6.3 -5.1 -5.4 -5.6 -5.1 -4.3 -5.0 -5.0 -5.2 -5.0 -4.3 -5.7 -5.1 -7.2 -5.2 -3.0 -5.0 -4.9 -3.3 -4.6 -6.4 -5.6
Blood Red Count 0.0 0.3 3.9 -0.2 0.1 0.3 -0.7 -0.8 -2.0 0.2 -0.1 -0.3 -0.1 -0.3 0.2 -0.5 0.1 0.3 0.3 -0.7 0.2 0.1 -1.0 0.4 -0.0
Blood White Count 0.5 3.5 10.7 2.4 -1.5 -1.7 -1.3 -1.8 -1.7 -0.9 -1.2 -2.5 -1.6 -2.3 -1.8 -2.0 -3.3 -1.5 -0.9 -3.1 -1.3 -0.6 -1.0 -2.6 -1.4
Heel T-Score 3.8 30.3 61.6 -6.0 5.7 6.5 4.8 6.4 7.8 3.6 5.7 6.4 5.0 7.8 6.0 4.8 3.8 5.6 1.4 5.8 4.7 3.9 6.1 4.3 5.2
BMI 0.3 1.7 6.7 -0.4 0.9 0.6 1.3 -0.1 -1.5 1.4 1.0 -0.5 1.0 1.2 0.9 1.3 2.5 1.4 2.6 -1.2 1.3 1.5 0.5 2.2 0.3
Height 1.9 37.5 87.4 5.5 -6.1 -5.4 -3.2 -4.4 -6.0 -6.1 -5.3 -3.0 -6.1 -7.2 -6.1 -4.9 -7.0 -6.5 -9.3 -4.0 -6.8 -6.4 -7.5 -7.3 -6.7
Waist Hip Ratio (WHR) 0.9 4.3 13.2 -1.8 1.9 1.3 3.6 0.2 -1.1 2.4 2.0 0.0 2.0 2.2 1.9 2.2 3.0 2.3 3.0 0.8 1.4 2.3 1.4 2.9 1.9
Systolic Blood Pressure 5.7 28.9 58.5 -4.8 5.4 4.3 6.4 4.1 5.6 5.0 5.6 2.6 5.7 4.9 5.3 5.8 5.5 5.9 5.8 2.8 5.5 6.0 7.7 5.8 5.2
Smoking Status 0.7 1.7 7.2 -2.1 0.8 1.1 1.0 0.8 -0.8 1.5 0.9 1.6 1.0 1.0 1.3 1.4 2.7 0.9 0.2 2.2 1.1 0.3 0.0 1.8 0.9
Allergy or Eczema 0.4 0.9 4.4 0.2 -0.3 -1.3 -0.3 -1.4 -1.3 -0.3 0.4 -1.9 -0.3 -1.0 -0.9 1.3 0.0 -0.1 1.1 -2.1 -0.3 0.6 -0.5 -0.4 -0.8
Cardiovascular Disease 1.2 4.1 7.7 -1.8 1.9 1.8 2.7 1.7 2.0 1.8 1.9 1.4 2.0 1.9 2.1 1.2 2.8 2.1 2.0 2.4 1.9 1.7 2.5 2.7 1.8
Hypothyroidism (self reported) 5.5 12.7 16.4 -3.7 3.5 3.8 3.4 3.2 3.5 3.3 3.5 3.1 3.5 3.7 3.8 3.7 3.9 3.8 2.3 3.8 3.3 3.3 4.1 4.0 3.8
Respiratory disease 1.4 3.0 8.0 -2.3 1.4 1.8 1.5 0.4 -0.3 1.5 1.8 1.3 2.0 2.2 1.7 2.1 2.8 2.2 1.8 0.5 1.5 2.0 0.9 2.3 1.1
Type 2 Diabetes (T2D) 0.2 0.4 1.6 -0.5 0.8 -0.1 1.3 0.1 0.3 0.9 0.8 -0.5 0.9 -0.1 0.4 0.3 -0.2 0.3 0.7 -0.5 0.8 0.7 0.6 0.2 0.3
Lung FEV1/FVC ratio 3.1 15.9 50.6 4.6 -3.6 -3.9 -3.5 -2.4 -0.5 -4.1 -3.7 -3.6 -4.1 -4.9 -4.1 -3.2 -7.1 -4.6 -2.6 -4.7 -3.4 -3.0 -1.9 -5.8 -3.5
Lung FVC 0.4 1.9 13.5 -0.3 0.7 -0.1 -0.7 -1.0 -2.0 1.4 0.3 -0.4 0.9 1.2 0.6 1.2 2.3 1.0 3.7 0.1 1.1 0.9 -0.5 2.5 1.2
Neuroticism 11.1 27.2 65.0 -6.4 5.0 5.1 5.6 4.2 2.6 4.9 5.1 4.7 5.1 5.6 5.4 5.1 8.1 5.5 3.5 5.4 4.7 4.2 4.8 6.7 4.8
Chronotype (morning person) 0.5 1.1 4.7 0.3 -0.5 0.2 -0.2 0.4 0.5 -0.8 -0.3 1.1 -0.9 -1.6 -0.3 -0.4 -2.2 -1.0 -2.1 -0.5 -0.4 -1.6 -1.5 -1.6 -0.8
Hair Pigment 0.1 1.8 5.3 -1.4 0.7 0.9 1.2 0.6 1.4 0.9 0.8 0.4 0.9 0.8 1.1 1.6 2.3 1.0 1.4 2.2 0.7 0.9 2.3 1.7 1.5
Tanning 0.8 11.2 16.5 3.4 -3.7 -3.5 -3.7 -2.7 -0.8 -3.3 -3.6 -1.9 -3.6 -3.6 -3.6 -3.6 -3.9 -4.1 -2.9 -2.7 -3.3 -3.6 -2.8 -3.9 -3.4
Hand grip strength (left) 6.2 16.6 27.3 5.2 -4.1 -4.3 -5.1 -2.5 -1.8 -3.8 -4.7 -2.2 -4.4 -4.9 -4.3 -3.7 -4.7 -5.1 -2.1 -2.7 -4.0 -4.4 -4.4 -4.2 -4.3
Number of treatments/medications taken 12.1 22.0 43.8 5.2 -4.7 -4.4 -5.4 -3.4 -2.3 -4.9 -4.4 -4.0 -4.9 -4.8 -5.0 -4.9 -6.6 -4.8 -3.9 -4.6 -4.9 -3.6 -3.9 -6.1 -4.5
Average weekly spirits intake 1.9 2.3 8.3 -1.4 0.9 1.8 1.0 2.6 2.9 1.3 0.8 2.5 1.2 1.3 1.6 0.5 1.5 1.2 0.6 1.9 1.0 0.5 1.4 1.5 1.1
Sensitivity / hurt feelings 1.1 1.9 5.2 1.1 -1.0 -1.5 -1.7 -2.0 -1.3 -1.1 -1.0 -2.0 -0.9 -1.8 -1.3 -0.7 -2.3 -1.3 -0.2 -1.9 -0.9 -0.4 -1.0 -1.7 -1.1
Frequency of depressed mood in last 2 weeks 2.2 3.1 8.7 2.3 -1.4 -1.2 -1.7 -1.1 -0.8 -1.6 -1.6 -1.0 -1.6 -2.6 -1.6 -1.0 -3.0 -1.6 -0.9 -2.4 -1.4 -1.4 -2.2 -2.3 -1.8
Hearing difficulty/problems: Yes 1.6 2.5 9.9 -1.1 1.5 2.2 -0.4 2.7 3.1 1.7 1.7 2.6 1.2 0.9 1.5 1.1 -1.4 1.1 -0.8 0.7 1.6 0.9 1.1 -0.3 1.1
Relative age of first facial hair 0.3 0.7 1.8 -0.5 1.0 0.5 -0.1 1.2 1.1 1.3 0.7 -0.2 0.8 0.8 0.7 -0.0 0.7 1.1 1.0 0.6 1.1 1.1 1.0 0.7 0.9
Other serious medical condition/disability diagnosed by doctor 2.3 3.0 8.8 1.8 -1.5 -1.6 -1.6 -1.0 -0.0 -1.7 -1.5 -1.3 -1.7 -2.0 -1.8 -1.8 -3.0 -1.6 -1.7 -2.4 -1.7 -1.2 -1.2 -2.3 -1.8
Ever used hormone-replacement therapy (HRT) 1.8 2.3 5.8 2.1 -1.5 -1.5 -1.7 -0.6 -0.0 -1.2 -1.3 -1.9 -1.4 -1.2 -1.6 -2.4 -2.2 -1.5 -0.6 -1.4 -1.3 -1.0 -0.9 -1.8 -1.7
Ever had hysterectomy (womb removed) 0.4 0.4 1.1 0.6 -0.4 -0.7 0.8 -0.6 0.5 -1.0 -0.3 -1.0 -0.3 -0.6 -0.5 -0.2 -1.1 -0.2 -0.3 -1.1 -0.5 0.1 0.4 -0.6 -0.6
Systolic blood pressure, automated reading 4.4 12.9 21.0 3.8 -3.6 -3.0 -4.6 -2.1 -3.1 -3.2 -3.8 -1.8 -4.0 -3.7 -3.6 -4.1 -3.7 -3.9 -4.1 -0.8 -3.8 -4.0 -4.5 -4.1 -3.4
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.9 1.3 -0.8 -0.4 -1.1 -0.4 -0.4 -1.2 -1.0 -0.3 -0.8 0.9 -0.8 -1.1 -1.4 -0.5 -0.7 -0.9 -1.0 -0.8 -0.4 -1.1 -0.6
Angina 3.0 3.9 7.8 0.8 -2.0 -1.8 -2.5 -2.8 -1.9 -1.7 -2.1 -1.2 -1.8 -1.8 -1.9 -2.1 -2.2 -2.3 -2.1 -1.7 -1.9 -1.7 -2.2 -2.2 -1.6
Medication for hormone replacement therapy 1.5 1.7 3.4 1.1 -1.1 -1.2 -1.3 -1.2 -0.4 -1.6 -1.2 -1.6 -1.4 -1.0 -1.2 -1.7 -1.6 -1.6 -1.0 -0.8 -1.1 -1.5 -1.1 -1.8 -1.1
Vitamin and mineral supplements 0.2 0.3 2.0 -0.7 -0.4 -0.6 0.1 -1.4 -0.6 -0.2 -0.2 -1.0 -0.2 0.6 -0.3 -0.3 0.8 0.0 0.3 -0.6 -0.4 0.5 -0.1 0.0 -0.4
Supplements: Zinc 0.6 0.6 2.3 1.5 -0.8 -0.5 -0.7 1.0 0.9 -0.6 -1.1 0.2 -0.8 -0.9 -0.6 -0.9 -0.5 -0.8 -0.5 -0.2 -0.8 -1.1 -0.7 -0.6 -0.8
Medication: Co-codamol 2.0 2.3 4.8 1.8 -1.4 -1.6 -1.5 -1.5 -1.1 -1.8 -1.3 -2.2 -1.6 -1.8 -1.6 -1.2 -2.1 -1.3 -1.1 -1.9 -1.2 -0.9 -0.5 -1.7 -1.3
Medication: Metformin 1.5 2.2 5.3 1.2 -2.2 -1.3 -2.3 -0.6 -1.1 -1.8 -1.6 -0.8 -2.0 -0.5 -1.7 -1.2 -0.5 -1.4 -2.0 0.6 -2.2 -1.5 -0.7 -1.5 -1.3
Diabetes (father) 0.4 0.6 1.4 0.7 -0.7 -1.0 -0.4 0.1 0.7 -0.6 -0.8 -0.7 -0.7 -0.5 -0.9 -0.1 -1.1 -1.0 -1.1 -0.5 -0.6 -0.8 0.5 -1.2 -0.5
Diabetes (mother) 0.1 0.1 0.5 -0.3 0.1 -0.0 0.7 -0.3 0.4 0.3 0.0 -0.2 0.2 0.7 0.0 -0.1 0.3 0.3 0.1 0.0 -0.1 0.2 0.5 0.3 0.6
Severe depression (siblings) 2.5 2.8 5.0 1.6 -1.7 -1.6 -2.1 -1.7 -1.3 -1.7 -2.0 -1.7 -1.6 -0.9 -1.7 -1.9 -2.2 -1.8 -1.1 -1.4 -1.5 -1.3 -1.7 -1.7 -1.7
Pack years adult smoking proportion 0.7 1.1 4.6 -0.8 1.4 0.7 0.4 0.1 0.6 0.7 1.2 -0.1 1.1 0.7 1.1 1.3 0.8 1.1 2.2 -0.6 1.3 1.3 0.7 1.2 1.1
Impedance of leg (right) 2.2 10.7 19.2 3.0 -2.7 -3.0 -4.4 -4.2 -3.5 -2.8 -2.7 -3.7 -2.6 -3.6 -3.3 -3.1 -4.3 -3.0 -1.3 -4.4 -2.0 -1.8 -3.7 -3.8 -3.1
Leg fat-free mass (left) 1.4 7.6 18.0 -3.0 2.5 2.7 1.5 2.8 3.8 2.3 1.9 3.3 2.3 2.9 2.8 1.9 3.4 2.4 2.4 4.2 2.1 1.6 2.9 3.0 3.1
Trunk fat percentage 2.6 10.7 23.0 2.9 -3.2 -2.3 -4.8 -1.1 0.8 -3.6 -3.4 -0.0 -3.4 -3.2 -3.1 -4.2 -4.5 -3.7 -3.8 -0.3 -3.1 -3.9 -3.1 -4.5 -3.0
Hand grip strength (right) 2.2 5.9 12.1 3.2 -2.0 -2.5 -3.5 -1.1 -1.5 -1.8 -2.8 -1.0 -2.4 -3.0 -2.3 -2.4 -2.7 -3.1 -0.4 -1.9 -1.8 -2.8 -3.5 -2.2 -2.7
Townsend deprivation index at recruitment 0.9 1.3 3.2 1.0 -0.9 -0.9 -1.4 -1.4 -0.1 -1.4 -0.4 -1.7 -1.1 -1.4 -1.1 0.0 -1.7 -0.8 0.0 -1.8 -1.0 -0.1 -0.1 -1.4 -1.3
Current tobacco smoking 0.1 0.2 0.7 -0.8 0.7 0.3 0.0 -0.6 0.6 -0.2 0.6 -0.3 0.5 0.5 0.4 0.3 -0.9 0.3 0.2 -0.7 0.5 0.6 0.4 -0.3 0.2
Average weekly fortified wine intake 1.3 1.5 5.1 1.3 -1.3 -1.0 -1.3 -0.5 -1.4 -1.3 -1.3 -0.9 -1.1 -1.5 -1.4 -1.3 -1.1 -1.3 -2.3 0.8 -1.2 -1.0 -0.5 -1.6 -0.5
Maternal smoking around birth 0.4 0.5 2.3 1.3 0.0 -0.3 -0.7 0.3 0.1 -0.4 -0.6 -0.2 -0.2 -0.4 -0.4 -1.4 -1.5 -0.3 -0.3 -1.2 -0.3 -0.1 -0.5 -0.9 -0.8
Fed-up feelings 10.0 18.5 37.9 4.7 -3.8 -4.4 -3.9 -4.6 -3.4 -4.2 -3.8 -4.8 -4.2 -4.2 -4.5 -3.3 -6.2 -4.3 -2.2 -5.6 -4.0 -2.8 -4.5 -5.2 -4.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 5.1 0.9 -0.8 -0.6 -1.7 -0.7 -0.6 -1.0 -1.0 0.0 -1.0 -2.0 -1.1 -1.0 -2.3 -1.1 -1.2 -0.6 -0.7 -0.8 -1.9 -1.7 -1.3
Relative age voice broke 0.1 0.1 0.5 0.2 0.2 0.2 -0.1 0.5 0.5 0.3 0.2 -0.1 -0.0 0.3 0.2 0.3 -0.2 0.2 0.1 0.3 0.1 0.3 0.7 0.1 0.4
Taking other prescription medications 11.5 17.8 35.7 4.3 -4.1 -3.9 -4.8 -3.5 -1.9 -4.9 -3.9 -3.7 -4.5 -4.0 -4.5 -4.3 -6.0 -4.3 -3.4 -4.2 -4.2 -3.5 -3.7 -5.5 -4.1
Age when periods started (menarche) 0.3 0.6 3.3 0.1 0.1 -1.0 0.0 -1.6 -0.9 -0.4 0.1 -1.8 -0.0 -0.4 -0.2 0.1 0.3 -0.2 1.8 -1.3 0.2 0.7 0.3 0.3 0.0
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 3.9 1.8 -1.7 -1.9 -0.1 -0.6 0.5 -1.4 -1.8 -1.1 -1.8 -1.4 -1.7 -1.4 -1.9 -1.9 -1.6 -1.0 -2.0 -1.8 -0.9 -1.4 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 3.9 8.9 16.4 3.9 -3.1 -3.6 -2.4 -2.6 -3.5 -1.3 -3.4 -2.9 -2.6 -3.8 -3.3 -2.6 -2.3 -3.0 -0.5 -3.8 -2.7 -2.3 -4.0 -2.5 -3.2
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 1.2 -0.4 0.2 0.5 0.1 0.9 -0.4 0.3 -0.0 0.8 0.1 0.1 0.3 0.1 -0.2 0.1 -1.1 -0.5 0.1 -0.2 -0.7 -0.0 0.0
Qualifications: CSEs or equivalent 0.3 0.4 1.7 0.3 -0.5 -0.4 0.1 -0.3 0.2 -0.9 -0.5 -0.2 -0.8 -0.4 -0.6 -0.3 -0.8 -0.6 -1.3 -0.1 -1.3 -0.7 0.3 -0.9 -0.4
Serious illness, injury or assault to yourself 0.3 0.3 1.3 -0.6 0.3 0.5 0.4 0.2 1.1 -0.4 -0.2 0.4 0.1 0.6 0.4 -0.8 -1.1 0.2 -1.1 -0.1 0.4 -0.0 0.6 -0.3 0.3
High blood pressure 0.7 2.0 6.3 1.5 -1.3 -0.9 -1.7 -0.4 -0.2 -1.3 -1.0 -0.6 -1.5 -1.2 -1.3 -0.8 -2.5 -1.4 -2.1 -1.6 -1.5 -1.2 -1.2 -2.3 -1.3
Hayfever, allergic rhinitis or eczema 0.6 1.3 4.8 -1.0 0.9 1.6 0.7 1.6 1.8 0.9 0.3 2.0 0.9 1.3 1.3 -0.5 0.3 0.6 -0.6 2.2 1.1 0.0 0.9 0.6 1.3
Multivitamins +/- minerals 0.2 0.3 2.0 0.9 0.0 0.1 -0.5 0.2 -0.1 -0.7 -0.2 0.1 -0.2 -0.2 -0.2 -0.3 -1.4 -0.5 -0.9 -0.4 -0.2 -0.6 -0.3 -0.6 -0.2
Stomach or abdominal pain in last month 1.3 1.6 4.4 2.1 -1.1 -1.1 -1.1 -0.8 0.2 -1.4 -1.2 -1.2 -1.1 -1.8 -1.2 -1.5 -2.0 -1.2 -0.4 -1.9 -0.9 -0.6 -0.9 -1.2 -1.1
Supplements: Glucosamine 0.2 0.3 1.3 -0.1 -0.3 -0.3 -0.6 0.2 -0.8 -0.6 -0.5 -0.4 -0.5 0.2 -0.2 -0.6 0.4 -0.3 -0.8 1.1 -0.5 -0.9 -0.5 -0.0 -0.3
Diverticular disease/diverticulitis (self-reported) 2.9 3.5 5.1 -2.0 1.7 1.6 2.0 1.4 2.1 2.1 2.2 1.5 2.2 1.1 1.8 2.2 1.9 2.1 1.9 0.5 1.6 2.3 2.1 1.9 1.8
Medication: Atenolol 4.5 5.7 9.3 2.4 -2.5 -2.6 -2.2 -2.1 -2.0 -1.9 -2.3 -2.3 -2.2 -2.1 -2.6 -2.6 -3.0 -2.7 -2.7 -2.2 -2.4 -2.0 -1.8 -3.0 -2.1
Medication: Levothyroxine sodium 3.4 5.7 10.1 2.2 -2.2 -2.4 -2.4 -2.4 -2.6 -1.9 -2.1 -2.1 -2.2 -1.9 -2.5 -1.9 -3.2 -2.7 -1.9 -3.0 -2.2 -2.4 -2.5 -3.1 -2.3
Sitting height 0.1 0.5 2.5 -1.3 0.1 0.1 0.5 -1.2 -0.2 -0.2 -0.6 0.3 0.0 1.0 0.4 -0.4 1.6 -0.2 1.4 0.4 0.1 -0.1 0.1 1.2 0.5
Chronic bronchitis/emphysema (father) 1.3 1.5 7.5 -0.3 1.2 0.2 0.5 0.6 -0.0 1.8 1.3 -0.4 1.3 0.6 0.9 1.6 1.0 1.3 2.7 0.3 1.4 1.6 1.2 1.3 1.4
High blood pressure (mother) 0.4 0.5 3.3 0.1 -0.7 -0.3 -0.4 0.4 -0.4 -0.1 -0.2 -0.0 -0.7 -0.4 -0.6 -0.2 -1.0 -0.8 -1.8 -0.0 -0.8 -1.1 -1.1 -1.0 -0.8
Body mass index (BMI) 0.6 2.6 7.3 1.2 -1.4 -1.3 -1.7 -0.5 1.2 -1.8 -1.4 -0.1 -1.6 -1.7 -1.5 -2.0 -2.7 -1.8 -2.2 0.2 -2.0 -1.7 -1.0 -2.4 -1.0
Impedance of leg (left) 2.5 12.2 21.1 3.6 -3.0 -3.3 -4.5 -4.0 -3.7 -2.9 -2.9 -4.0 -3.0 -3.8 -3.5 -3.0 -4.6 -3.3 -1.3 -4.6 -2.1 -2.0 -4.0 -4.0 -3.5
Leg predicted mass (left) 1.4 7.6 17.7 -3.0 2.5 2.7 1.5 2.7 3.7 2.3 1.9 3.3 2.4 2.9 2.8 2.0 3.4 2.4 2.4 4.2 2.1 1.7 2.9 3.0 3.1
Trunk fat mass 0.9 4.0 12.0 1.5 -1.7 -1.2 -3.5 -0.2 1.9 -2.1 -2.1 0.6 -1.9 -1.7 -1.7 -2.9 -2.9 -2.3 -2.1 0.5 -1.7 -2.4 -1.5 -2.8 -1.4
Waist circumference 0.3 1.3 5.8 0.1 -0.6 -0.4 -1.9 0.4 2.4 -0.9 -0.7 0.9 -0.7 -0.9 -0.6 -1.2 -1.8 -1.1 -1.6 1.0 -0.7 -1.1 -0.0 -1.6 -0.2
Number of incorrect matches in round 0.7 1.1 3.8 0.8 -0.8 -0.8 -0.3 -0.8 -0.5 -1.1 -1.0 -0.7 -0.9 -1.0 -0.9 -1.2 -1.4 -0.9 -1.2 -1.9 -1.0 -1.1 -1.2 -1.4 -1.2
Past tobacco smoking 3.1 5.7 14.8 -3.5 2.1 2.2 1.8 1.5 0.4 2.8 2.1 2.8 2.5 2.4 2.5 2.9 3.9 2.3 1.5 2.6 2.4 1.5 1.3 3.1 1.9
Alcohol usually taken with meals 0.9 1.4 8.7 -1.0 0.6 1.3 0.1 1.5 2.3 0.6 0.4 1.5 0.6 0.1 1.0 0.1 1.6 1.0 0.1 3.0 0.6 0.6 1.2 1.1 0.9
Nervous feelings 12.2 23.1 37.1 5.2 -5.0 -4.7 -5.0 -4.1 -2.7 -5.4 -5.0 -4.1 -5.2 -4.6 -5.2 -4.8 -6.1 -5.1 -4.4 -3.8 -5.2 -4.2 -4.1 -5.9 -4.6
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.2 7.4 2.0 -1.7 -1.3 -2.3 -1.2 -0.1 -2.4 -1.8 -1.4 -1.8 -1.6 -1.7 -1.4 -2.7 -1.7 -1.5 -1.9 -1.4 -1.6 -1.4 -2.2 -2.2
Hearing difficulty/problems with background noise 0.8 1.3 5.7 1.0 -0.7 0.0 -2.0 0.8 2.1 -0.8 -0.6 0.4 -0.7 -1.0 -0.7 -0.8 -2.4 -0.8 -1.7 -0.0 -0.7 -0.9 0.0 -1.6 -0.6
Hair/balding pattern: Pattern 2 0.4 0.5 1.8 0.4 -0.3 -0.6 -0.7 -0.9 0.4 -0.1 0.1 -1.3 -0.2 -0.8 -0.6 -0.2 -1.3 -0.2 0.7 -1.0 0.2 0.7 0.6 -1.1 -0.3
Had menopause 0.2 0.2 1.1 0.9 -0.4 -0.4 -1.1 0.2 0.4 -0.3 -0.3 -0.7 -0.2 -0.2 -0.4 -0.4 -0.4 -0.2 0.2 -0.4 -0.1 0.3 0.4 -0.7 -0.3
Had other major operations 0.3 0.4 2.4 0.4 0.1 -0.4 0.2 0.2 1.2 -0.5 -0.1 -0.6 0.1 -0.1 -0.1 0.3 -1.3 -0.1 0.3 0.1 0.1 0.4 1.6 -0.7 0.5
Forced vital capacity (FVC) 0.8 3.1 6.5 -2.2 2.0 2.1 1.5 2.1 2.6 1.4 1.7 1.5 1.6 1.2 2.0 1.3 1.4 1.5 1.0 1.9 1.9 1.4 2.3 1.3 1.6
Heel bone mineral density (BMD) T-score, automated (right) 3.3 7.6 14.6 3.5 -2.9 -3.1 -2.3 -2.8 -3.2 -1.4 -2.9 -2.1 -2.4 -3.7 -3.0 -2.3 -2.4 -2.7 -0.6 -3.6 -2.4 -2.0 -3.8 -2.4 -3.0
Ever unenthusiastic/disinterested for a whole week 5.3 6.5 14.7 2.2 -2.1 -2.4 -2.2 -3.2 -2.0 -3.4 -2.1 -3.2 -2.1 -1.8 -2.5 -2.5 -3.8 -2.5 -1.5 -3.4 -2.1 -1.7 -2.1 -3.1 -2.3
Qualifications: None of the above 0.3 0.7 3.9 -0.4 0.7 0.4 -0.3 -0.6 -0.2 0.1 1.0 -0.6 0.6 0.5 0.2 -0.1 -1.9 0.5 -0.4 -2.0 0.8 1.2 0.0 -1.1 0.4
Financial difficulties in last 2 years 0.5 0.7 4.2 -0.5 0.6 0.5 0.9 0.5 2.1 0.6 0.5 -0.1 0.6 0.3 0.7 0.6 0.7 0.9 1.5 -0.3 0.6 0.8 1.4 0.9 0.6
Mouth/teeth dental problems 0.8 1.3 4.2 -1.3 0.7 0.8 0.2 -0.0 -0.7 1.6 1.2 1.1 1.0 0.7 0.9 1.4 2.0 0.9 1.2 1.6 1.2 0.6 0.2 1.5 1.2
Heart attack 1.0 1.3 3.7 1.0 -1.0 -1.2 -1.7 -1.6 -1.5 -0.9 -0.9 -1.0 -1.0 -0.6 -1.1 -0.7 -1.2 -1.0 0.1 -1.9 -1.0 -0.5 -1.6 -1.0 -1.1
Allergy 0.3 0.8 5.3 0.0 -0.5 -1.0 -0.2 -1.6 -2.3 -0.4 0.2 -1.4 -0.3 -0.5 -0.8 0.6 0.7 0.1 0.7 -1.3 -0.7 0.3 -0.8 0.1 -1.0
Pain all over the body in last month 0.8 0.8 2.0 -1.2 0.9 1.0 1.4 0.4 0.9 0.7 1.1 1.1 0.9 1.3 1.1 1.1 -0.2 0.7 0.1 -0.7 1.1 0.8 0.8 0.4 0.4
Diabetes (self-reported) 1.0 1.6 3.8 1.5 -1.9 -1.0 -1.7 -0.7 -1.2 -1.6 -1.5 -0.4 -1.7 -0.7 -1.4 -1.1 -0.8 -1.0 -1.5 -0.2 -1.9 -1.3 -1.1 -1.1 -1.0
Hayfever/allergic rhinitis (self-reported) 0.3 0.3 1.9 -0.2 0.4 0.3 -0.4 1.0 0.6 0.7 -0.0 0.7 0.5 -1.1 0.2 -0.1 0.0 -0.2 -0.5 1.4 0.7 0.3 0.0 -0.3 0.7
Medication: Ramipril 1.1 1.4 2.7 1.1 -1.5 -1.1 -1.6 -0.9 -1.2 -0.3 -1.4 -0.4 -1.3 -0.8 -1.3 -0.7 -1.6 -1.4 -1.4 -0.8 -1.3 -1.3 -1.5 -1.4 -0.8
Medication: Simvastatin 4.1 5.9 9.2 2.9 -2.9 -3.0 -2.1 -2.2 -1.3 -2.4 -2.6 -2.7 -2.6 -2.0 -2.9 -2.3 -2.4 -2.4 -1.1 -2.7 -2.9 -1.8 -1.8 -2.8 -2.5
Fluid intelligence score 0.3 0.5 1.8 0.3 -1.1 -0.6 0.5 -0.5 0.5 -0.2 -0.9 0.1 -1.0 0.2 -0.5 0.2 1.3 -0.6 0.0 1.3 -1.2 -1.0 0.2 0.6 -0.5
Illnesses of siblings 1.1 1.6 4.8 -1.1 1.2 1.0 2.2 0.7 0.1 1.1 1.0 0.8 1.4 1.1 1.2 1.0 1.9 1.5 1.5 0.7 1.0 1.4 1.2 1.5 1.5
Neuroticism score 10.3 21.9 49.1 5.3 -4.5 -4.7 -5.2 -4.4 -2.1 -4.6 -4.6 -4.6 -4.7 -4.8 -4.9 -4.3 -7.0 -4.9 -2.8 -4.9 -4.4 -3.5 -4.1 -5.9 -4.5
Weight 0.2 1.1 8.0 -1.1 0.8 0.8 -0.8 1.1 2.8 0.5 0.4 1.5 0.6 0.6 0.8 -0.1 0.0 0.4 0.7 2.1 0.5 0.3 1.1 0.2 1.3
Impedance of arm (right) 0.3 1.5 4.7 0.9 -0.9 0.2 -2.2 0.6 0.1 -1.2 -1.0 1.4 -0.9 -0.9 -0.7 -0.9 -1.6 -1.2 -1.9 -0.3 -0.0 -1.8 -1.7 -1.6 -1.4
Arm fat percentage (right) 1.4 5.7 14.4 1.8 -2.1 -1.2 -3.0 0.2 1.8 -2.7 -2.2 0.9 -2.4 -2.2 -1.9 -2.7 -3.8 -2.7 -3.8 0.3 -2.3 -3.0 -1.9 -3.5 -2.1
Trunk fat-free mass 2.4 14.0 24.2 -4.0 3.9 3.0 2.7 2.3 3.5 4.0 3.3 1.8 3.8 4.0 3.8 3.4 4.6 3.9 4.9 3.1 3.5 4.1 4.5 4.4 4.3
Hip circumference 0.5 2.2 8.2 -2.1 1.5 1.3 0.0 1.4 2.9 1.5 1.4 2.0 1.3 0.7 1.4 0.8 0.5 1.1 0.8 2.4 1.4 1.0 1.6 0.7 2.0
Time employed in main current job 0.9 1.1 2.4 0.9 -1.4 -1.1 -1.3 -1.0 -0.9 -0.9 -0.8 -0.9 -1.5 -1.2 -1.1 -0.8 -0.1 -1.0 -0.6 -0.2 -1.3 -1.4 -1.0 -0.7 -1.5
Alcohol intake versus 10 years previously 0.6 1.0 4.0 -1.2 1.0 1.2 0.5 0.5 2.0 0.4 1.4 0.5 0.9 0.9 0.9 0.8 0.3 1.3 0.8 0.5 0.4 1.4 1.4 0.6 0.4
Father’s age at death 3.7 4.9 11.6 -2.8 1.7 2.0 1.4 1.2 1.7 2.0 2.4 1.3 1.9 2.2 2.1 2.8 3.4 2.4 2.2 3.0 1.8 1.8 2.3 2.6 2.3
Worrier / anxious feelings 11.7 22.3 40.8 6.0 -5.3 -4.6 -5.2 -3.5 -1.4 -5.1 -5.0 -4.0 -5.0 -4.5 -5.3 -4.3 -6.4 -5.2 -3.7 -3.9 -4.6 -4.2 -3.4 -5.9 -4.7
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 8.8 1.1 -0.2 -0.4 -0.8 -0.4 1.2 -1.5 -0.2 -0.7 -0.6 -1.7 -0.6 -0.2 -3.0 -0.7 -0.4 -2.3 -0.3 -0.1 -0.6 -1.4 -1.1
Falls in the last year 1.1 1.5 3.2 -1.3 1.1 1.5 0.5 1.4 1.8 1.3 1.3 1.6 1.3 1.7 1.4 1.2 -0.1 1.3 0.3 0.3 1.2 1.1 1.7 0.6 1.1
Hair/balding pattern: Pattern 3 0.1 0.2 0.8 0.3 0.3 0.4 0.9 0.9 0.0 0.2 0.2 0.1 0.2 0.4 0.4 0.2 0.9 0.2 0.2 -0.1 -0.1 -0.0 0.4 0.7 0.8
Number of live births 0.2 0.3 1.7 -0.6 0.5 0.8 0.6 0.2 0.1 -0.3 0.4 0.8 0.5 1.3 0.6 0.0 0.3 0.7 -0.1 0.9 0.3 0.3 0.7 0.5 0.5
Forced expiratory volume in 1-second (FEV1) 1.3 4.4 7.5 -2.7 2.3 2.5 2.0 2.3 2.1 1.8 1.9 2.1 2.1 2.0 2.3 1.3 2.5 2.0 0.8 2.7 2.1 1.6 1.9 2.1 2.0
Pulse rate 0.3 0.5 1.8 -0.4 0.9 0.3 1.0 -0.0 0.2 0.6 0.7 0.4 0.6 0.2 0.7 1.1 0.6 0.6 1.3 0.0 1.0 0.7 0.2 1.4 0.5
Happiness 2.1 2.5 5.3 1.9 -1.5 -1.9 -1.5 -1.8 -0.6 -2.1 -1.6 -2.2 -1.6 -1.8 -1.7 -1.1 -2.3 -1.6 -0.6 -1.2 -1.5 -0.8 -1.1 -2.0 -1.3
Noisy workplace 0.2 0.3 1.3 0.1 -0.1 -0.3 -0.3 -0.4 0.5 -0.8 -0.1 -0.8 -0.2 -0.1 -0.3 -0.6 -0.9 0.0 -0.3 -1.2 -0.3 0.3 0.1 -0.7 -0.6
Qualifications: A levels/AS levels or equivalent 1.5 3.3 8.6 -1.5 1.5 2.3 2.9 1.9 0.9 1.3 1.5 2.3 1.5 2.1 2.1 1.5 2.6 1.9 0.3 1.6 1.2 1.0 1.5 2.6 1.5
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 2.7 -1.1 0.7 0.9 0.9 0.6 1.6 0.0 0.8 1.1 0.3 1.5 0.8 0.9 0.3 0.7 -0.1 0.7 0.4 0.1 0.6 0.4 0.5
Mouth/teeth dental problems: Dentures 0.2 0.4 1.1 -0.3 0.8 1.0 0.7 0.7 0.6 0.3 0.6 0.3 0.7 0.5 0.8 0.1 -0.5 0.8 0.5 -0.2 0.6 0.9 0.9 0.1 1.0
Asthma 1.1 2.2 5.5 1.7 -1.3 -1.8 -1.8 -0.8 0.1 -1.5 -1.5 -1.5 -1.7 -1.6 -1.6 -1.6 -2.3 -2.0 -1.1 -0.5 -1.1 -1.4 -0.3 -2.2 -1.0
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 3.7 1.6 -1.1 -0.9 -0.6 0.1 0.4 -0.5 -1.5 -0.1 -1.3 -1.7 -1.1 -1.7 -1.9 -1.5 -1.5 -1.3 -1.1 -1.4 -0.8 -1.5 -1.4
Medication: Cholesterol lowering 1.9 3.0 5.7 1.4 -2.3 -2.0 -2.1 -1.2 -1.0 -1.5 -2.3 -1.1 -2.1 -1.3 -2.0 -1.8 -1.1 -1.9 -1.7 -0.1 -2.4 -1.9 -1.5 -1.8 -1.6
Depression (self-reported) 0.4 0.5 3.8 0.8 -0.1 -0.2 -0.6 -0.5 0.2 -0.6 -0.3 -0.9 -0.3 -1.0 -0.3 -0.8 -1.9 -0.4 -0.1 -0.7 -0.0 0.0 -0.0 -1.1 0.0
Medication: Lansoprazole 1.7 1.9 11.6 1.5 -0.6 -0.7 -1.9 -0.9 -0.3 -1.3 -0.5 -0.6 -0.8 -1.2 -1.1 -1.2 -3.4 -1.0 -0.8 -2.0 -0.6 -0.3 -1.6 -2.4 -1.0
Prospective memory result 0.6 0.7 1.8 -0.9 0.7 0.6 0.6 0.7 0.8 1.3 0.7 0.3 1.0 0.6 0.8 0.4 0.7 0.8 1.1 0.2 1.2 1.0 1.2 0.7 0.9
Lung cancer (father) 1.0 1.2 2.5 -1.2 1.3 0.9 1.3 0.4 -0.2 1.6 1.3 0.2 1.4 1.3 1.2 1.0 0.3 1.2 0.8 -1.0 1.2 1.5 0.8 0.8 1.6
Illnesses of mother 0.5 0.6 1.7 -0.8 0.8 0.7 0.2 0.5 1.3 0.2 -0.2 0.7 0.7 0.8 0.7 -0.2 1.2 0.3 0.7 1.1 0.8 0.3 1.0 0.9 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.2 6.8 -2.6 2.4 2.5 2.2 2.0 1.9 1.6 2.1 1.9 2.2 2.2 2.3 1.6 2.3 2.2 0.7 2.1 2.0 1.9 1.8 2.0 1.9
Pulse wave Arterial Stiffness index 0.7 0.9 3.4 -0.9 1.0 1.0 1.6 1.3 0.3 0.6 0.7 1.3 0.9 1.8 1.0 -0.1 0.9 1.0 -0.3 -0.1 0.9 0.6 0.3 0.9 0.6
Impedance of arm (left) 0.3 1.4 3.9 1.1 -1.0 -0.0 -2.0 0.6 -0.3 -1.1 -1.1 1.2 -1.0 -0.9 -0.7 -1.1 -1.3 -1.1 -1.6 -0.4 -0.0 -1.8 -1.8 -1.3 -1.4
Arm fat mass (right) 0.5 2.0 5.3 0.9 -1.0 -0.7 -2.2 0.1 1.8 -1.5 -1.2 0.5 -1.3 -1.2 -1.1 -1.7 -2.3 -1.5 -1.8 0.6 -1.4 -1.6 -0.7 -2.1 -0.9
Trunk predicted mass 2.4 14.0 25.0 -4.0 3.9 3.0 2.7 2.3 3.5 4.0 3.3 1.8 3.8 4.0 3.7 3.5 4.6 3.9 5.0 3.1 3.5 4.1 4.5 4.4 4.3
Standing height 2.2 22.5 44.7 -5.0 4.9 4.4 2.1 3.5 4.0 5.1 4.0 3.1 4.8 5.0 5.0 4.0 5.9 4.8 6.7 3.9 5.5 4.6 5.0 5.7 5.2
Length of working week for main job 0.5 0.6 2.8 -0.2 0.8 -0.2 0.3 -0.1 -0.6 0.7 0.2 -1.0 0.8 0.2 0.3 0.4 0.6 0.6 1.7 -0.5 0.6 1.4 1.2 0.7 0.6
Exposure to tobacco smoke at home 0.2 0.2 0.8 0.5 -0.2 -0.3 0.1 0.4 0.9 0.3 -0.4 0.0 -0.1 -0.3 -0.3 -0.8 -0.5 -0.2 -0.2 0.8 -0.2 -0.2 0.2 -0.3 -0.4
Breastfed as a baby 0.7 0.9 3.9 -0.4 0.4 0.7 0.9 1.6 0.8 0.8 0.4 1.0 0.7 0.7 0.7 0.8 1.6 0.6 1.0 2.0 0.5 0.1 0.7 1.2 1.1
Tense / ‘highly strung’ 4.4 7.4 19.2 2.7 -2.6 -2.1 -3.3 -1.3 -0.3 -2.5 -2.9 -1.6 -2.7 -3.0 -2.7 -2.8 -4.4 -3.1 -3.0 -1.8 -2.4 -2.7 -2.3 -3.9 -2.5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.9 4.5 20.7 2.2 -1.7 -1.6 -2.4 -1.4 -0.1 -2.2 -1.5 -2.4 -1.9 -1.6 -2.0 -1.6 -4.5 -1.9 -2.3 -2.2 -1.8 -1.4 -0.9 -3.4 -1.7
Hair/balding pattern: Pattern 4 0.4 1.1 3.6 -0.7 0.7 0.8 0.9 1.6 1.3 0.9 0.4 1.1 0.6 1.5 0.9 0.8 1.9 1.1 0.7 1.2 0.7 0.8 0.9 1.5 0.1
Birth weight of first child 1.6 2.9 6.3 -1.7 1.7 1.8 1.3 1.6 2.1 1.3 1.7 1.1 1.7 1.7 1.7 1.4 1.6 1.7 0.9 1.8 1.9 1.6 2.5 1.5 1.9
Peak expiratory flow (PEF) 0.1 0.2 0.8 -0.2 0.4 -0.2 -0.3 -0.0 -0.7 0.6 0.3 -0.5 0.3 -0.5 0.1 -0.1 0.7 -0.0 0.5 0.9 0.4 0.4 -0.4 0.3 0.4
Pulse wave reflection index 1.3 1.6 4.1 -1.6 1.2 1.3 2.0 1.2 0.8 1.1 1.2 0.7 1.4 1.6 1.3 0.6 1.7 1.7 0.3 0.7 0.8 1.3 1.6 1.1 0.9
Ever highly irritable/argumentative for 2 days 1.1 1.3 3.1 1.2 -0.9 -1.3 -1.3 -0.1 -0.7 -1.1 -1.1 -1.3 -1.2 -0.8 -1.2 -0.7 -1.8 -1.3 -1.0 -1.5 -0.9 -0.9 -1.0 -1.6 -1.2
Loud music exposure frequency 0.3 0.3 2.8 -0.1 0.3 0.7 -0.4 0.9 0.9 0.8 0.1 1.7 0.5 0.2 0.4 0.3 -0.4 0.1 -0.0 0.5 0.7 -0.1 -0.4 0.2 0.5
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 3.0 0.0 0.5 1.0 1.2 1.4 -0.3 0.2 0.2 1.0 0.3 0.8 0.8 0.8 1.0 0.6 -0.3 1.7 0.4 -0.2 0.2 0.9 0.5
Mouth/teeth dental problems: Bleeding gums 2.0 2.6 8.5 1.3 -1.5 -1.5 -1.4 -1.3 -0.8 -1.9 -1.7 -1.4 -1.6 -1.6 -1.6 -1.5 -1.5 -1.7 -1.1 -2.9 -1.5 -1.3 -1.6 -1.7 -2.1
Blood clot in the leg (DVT) 0.5 0.6 2.9 0.0 0.7 0.7 1.7 1.1 1.6 1.0 0.3 0.5 0.9 -0.0 0.7 0.2 -0.0 0.7 0.3 -0.4 0.7 0.7 0.9 0.6 0.7
Medication: Paracetamol 4.0 6.7 12.4 3.1 -2.9 -2.6 -2.0 -1.4 -1.4 -2.9 -2.7 -1.5 -2.9 -3.1 -2.9 -2.8 -3.5 -2.9 -2.1 -2.0 -2.6 -2.4 -2.1 -3.0 -3.0
Headache pain in last month 1.3 2.4 10.8 1.6 -1.2 -1.2 -0.7 -1.7 -0.7 -2.2 -0.8 -1.4 -1.3 -1.3 -1.5 -0.9 -3.3 -1.4 -1.2 -2.3 -1.0 -0.9 -0.7 -2.3 -1.5
Medication for cholesterol, blood pressure or diabetes 1.8 3.0 6.1 -1.7 2.2 1.9 1.8 1.1 0.8 1.9 2.0 1.6 2.2 1.0 2.1 1.3 1.7 1.9 1.5 0.9 2.5 1.4 1.1 2.2 1.9
Glaucoma (self-reported) 1.8 2.1 4.8 1.8 -1.6 -0.9 -2.2 -0.0 1.1 -0.9 -1.4 0.2 -1.4 -1.9 -1.2 -1.5 -1.8 -2.0 -0.8 -1.3 -0.9 -1.7 -1.2 -1.5 -1.8
Gout (self-reported) 0.6 0.9 4.9 0.7 -0.3 -0.7 0.1 -2.0 -1.4 -0.6 -0.3 -1.6 -0.2 0.6 -0.6 -1.0 -0.1 0.1 0.4 -2.2 -0.8 0.6 -0.2 -0.3 -0.9
Hypothyroidism/myxoedema (self-reported) 4.4 8.5 12.2 3.1 -2.9 -3.3 -3.1 -2.9 -2.7 -2.6 -2.7 -3.2 -2.9 -2.8 -3.3 -2.7 -3.3 -3.2 -1.7 -2.9 -2.7 -2.5 -2.5 -3.5 -3.0
Medication: Amlodipine 1.4 1.9 10.6 0.4 -0.7 -0.9 -0.6 -2.3 -3.3 -1.4 -0.2 -1.2 -0.6 -0.8 -1.0 -0.5 -1.1 -0.7 -0.6 -2.9 -0.9 -0.1 -2.2 -1.2 -1.2
Medication: Ventolin 100micrograms inhaler 0.4 0.5 2.1 0.6 0.1 -1.2 -1.1 -1.1 -0.4 -0.8 -0.2 -1.3 -0.2 -0.3 -0.6 -0.0 0.1 -0.7 1.5 0.2 -0.2 0.2 -0.3 -0.1 0.0
Birth weight 0.4 0.9 4.7 -0.7 0.6 -0.0 0.4 -1.0 -0.5 0.4 0.5 -1.7 0.8 0.5 0.5 0.7 0.8 0.7 2.2 -1.4 0.8 1.3 1.3 0.8 0.7
Chronic bronchitis/emphysema (mother) 0.7 0.8 3.9 1.0 -0.3 -0.9 -0.1 -1.4 -0.0 -0.0 0.4 -1.9 -0.1 -0.8 -0.6 0.2 -1.2 0.2 1.3 -2.0 0.3 1.1 1.0 -0.5 -0.1
High blood pressure (siblings) 0.2 0.4 1.4 0.7 -0.4 -0.8 -0.7 -0.4 -0.6 -0.3 -0.4 -1.2 -0.4 -0.6 -0.5 -0.7 -0.8 -0.5 0.3 -1.1 -0.2 -0.3 -0.5 -0.4 -0.6
Forced vital capacity (FVC), Best measure 0.9 3.4 6.4 -2.3 2.1 2.2 1.8 2.0 2.5 1.2 1.9 1.5 1.8 1.9 2.0 1.7 1.4 1.9 0.9 1.7 1.8 1.8 2.4 1.4 1.6
Body fat percentage 3.0 12.2 25.3 3.2 -3.4 -2.6 -4.9 -1.6 0.4 -3.9 -3.5 -0.6 -3.6 -3.5 -3.4 -4.4 -5.0 -3.9 -4.0 -0.9 -3.4 -3.9 -3.4 -4.8 -3.2
Leg fat percentage (right) 3.9 14.5 33.3 3.5 -3.5 -3.3 -5.0 -3.1 -0.8 -4.3 -3.5 -2.4 -3.7 -4.1 -3.8 -4.6 -5.8 -4.0 -3.4 -2.4 -3.9 -3.2 -3.7 -5.3 -3.4
Arm fat-free mass (right) 1.1 5.5 12.9 -2.5 2.4 1.5 1.5 1.0 2.3 2.5 1.9 0.7 2.3 2.3 2.2 1.8 2.9 2.3 3.6 2.4 2.0 2.6 3.0 2.8 3.0
Exposure to tobacco smoke outside home 0.9 1.2 4.1 1.2 -0.8 -0.7 -1.8 -0.3 -0.2 -0.5 -1.0 -0.2 -1.0 -1.8 -1.0 -0.9 -2.0 -1.3 -1.3 -0.7 -0.9 -0.7 -0.9 -1.6 -0.8
Comparative body size at age 10 0.6 1.8 4.6 -2.1 1.1 1.8 2.1 1.3 1.6 0.6 1.1 2.1 1.1 1.6 1.6 0.9 1.0 1.0 -0.5 1.3 0.7 0.2 1.2 1.0 1.1
Number of full brothers 0.2 0.2 0.7 0.7 -0.7 -0.8 -0.3 0.0 0.3 -0.0 -0.3 -0.7 -0.6 -0.4 -0.7 -0.1 -0.5 -0.4 -0.1 0.4 -0.7 -0.4 0.0 -0.5 -0.3
Worry too long after embarrassment 0.5 0.8 3.0 1.7 -1.0 -1.3 -0.9 -0.9 -0.4 -0.9 -1.0 -1.7 -0.8 -0.4 -1.1 -0.7 -1.0 -0.9 0.6 -0.9 -0.4 -0.5 0.1 -0.8 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.8 2.4 10.3 1.4 -1.1 -1.2 -1.6 -1.1 0.8 -1.5 -1.0 -1.5 -1.4 -2.2 -1.4 -0.8 -3.2 -1.4 -1.0 -2.2 -1.3 -1.0 -0.2 -2.3 -1.3
Wheeze or whistling in the chest in last year 1.7 3.0 14.6 1.5 -1.1 -1.3 -2.2 -0.8 -0.7 -1.5 -1.0 -0.9 -1.5 -2.3 -1.4 -1.2 -3.8 -1.9 -1.7 -1.8 -1.0 -1.3 -1.5 -2.8 -1.5
Number of children fathered 1.2 1.3 3.7 1.3 -1.2 -0.5 -0.9 -0.2 -1.4 -0.2 -0.9 -0.1 -1.0 -1.6 -1.0 -1.2 -1.3 -1.0 -1.9 -1.4 -1.1 -1.2 -1.8 -1.0 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 3.3 1.0 -1.2 -1.0 -0.6 -1.5 -0.6 -1.1 -1.0 -1.4 -1.0 -0.9 -1.1 -1.8 -1.5 -0.9 -1.1 -0.8 -0.9 -0.5 0.4 -1.3 -1.0
Age at first live birth 2.4 4.4 11.2 -1.6 1.9 1.2 2.0 1.2 0.2 2.4 2.0 -0.0 2.0 2.8 1.8 2.8 3.3 2.2 2.9 1.0 1.8 2.3 2.2 2.9 1.8
Pulse wave peak to peak time 0.6 0.7 2.7 0.6 -0.8 -0.9 -1.6 -1.3 -0.3 -0.4 -0.6 -1.3 -0.8 -1.6 -0.8 0.3 -0.7 -0.8 0.8 0.3 -0.7 -0.4 -0.1 -0.7 -0.3
Health satisfaction 1.3 1.7 8.1 1.3 -1.1 -0.7 -0.7 -0.4 0.3 -1.7 -1.2 -0.1 -1.1 -1.0 -1.1 -1.5 -2.8 -0.9 -2.3 -1.2 -1.2 -1.0 -1.2 -2.0 -1.1
Shortness of breath walking on level ground 2.7 3.2 5.8 0.7 -1.6 -1.5 -1.7 -1.9 -1.8 -1.6 -1.8 -0.6 -1.8 -1.8 -1.6 -2.2 -2.3 -1.8 -2.4 -1.3 -1.7 -1.7 -2.3 -2.0 -2.0
Qualifications: College or University degree 0.4 1.3 7.1 -0.3 0.1 0.6 1.8 1.2 1.5 1.5 0.1 0.4 0.6 0.6 0.7 1.0 2.7 0.7 1.0 0.4 0.4 0.4 1.8 1.8 0.9
Eye problems/disorders: None of the above 1.0 1.1 4.7 1.1 -0.9 -1.6 -0.5 -1.1 -1.0 -0.7 -0.7 -2.2 -1.0 -0.9 -1.3 0.0 -1.1 -1.3 -0.6 -1.3 -1.0 -0.7 -0.2 -1.1 -0.9
Mouth/teeth dental problems: Loose teeth 0.2 0.3 1.1 0.2 0.7 -0.0 0.0 0.2 -0.7 0.3 0.5 -0.7 0.7 0.8 0.1 -0.0 -0.0 0.6 0.7 0.0 0.5 1.0 0.4 0.1 -0.1
Emphysema/chronic bronchitis 1.6 1.8 4.5 -1.1 1.7 1.3 1.3 0.8 1.0 1.2 1.6 0.8 1.3 0.9 1.6 2.1 0.7 1.5 1.8 -0.3 1.7 1.3 1.0 1.6 1.4
Medication for pain relief, constipation, heartburn 7.9 13.7 24.3 -4.2 4.1 3.7 3.5 2.3 1.2 4.0 3.9 2.5 4.2 3.5 4.2 4.1 4.9 4.0 3.0 3.0 4.1 3.2 2.8 4.7 4.1
Neck or shoulder pain in last month 0.3 0.4 2.3 -0.2 0.9 0.3 0.2 0.6 0.8 0.1 0.7 -0.4 0.5 0.0 0.4 -0.1 -1.5 0.1 -0.6 -0.0 0.5 0.9 0.9 -0.9 0.2
Medication: Blood pressure 1.9 3.4 5.4 1.8 -2.1 -2.1 -1.8 -1.9 -1.6 -2.2 -1.8 -2.2 -2.1 -0.9 -2.2 -1.4 -1.8 -1.9 -1.3 -1.7 -2.3 -1.0 -1.3 -2.2 -2.0
Angina (self-reported) 2.7 3.5 7.3 0.6 -2.0 -1.6 -2.4 -2.7 -1.8 -1.7 -2.1 -0.8 -1.7 -1.6 -1.8 -2.2 -1.9 -2.2 -2.3 -1.4 -1.9 -1.8 -2.2 -2.1 -1.6
Migraine (self-reported) 2.4 3.0 9.1 2.6 -1.7 -1.7 -1.1 -1.3 -1.3 -1.4 -1.6 -1.3 -1.4 -1.6 -1.8 -1.2 -3.0 -1.8 -1.0 -2.6 -1.5 -1.3 -1.5 -2.2 -1.2
Medication: Ibuprofen 0.7 0.8 2.3 1.2 -0.8 -0.5 -0.3 0.4 0.8 -0.1 -1.1 0.1 -0.9 -1.5 -0.8 -1.5 -1.2 -0.9 -1.1 -0.7 -0.7 -0.9 -0.5 -1.0 -0.9
Medication: Allopurinol 1.8 2.4 6.3 1.6 -1.4 -1.8 -0.4 -2.4 -2.0 -1.1 -1.5 -2.3 -1.4 -1.1 -1.6 -2.0 0.0 -0.9 -0.2 -2.5 -2.0 -0.8 -1.1 -0.7 -2.1
Medication: Omeprazole 1.6 1.9 7.0 2.0 -1.1 -1.6 -0.3 -0.7 -0.9 -1.4 -0.8 -1.5 -1.2 -1.3 -1.4 -0.4 -2.3 -1.4 -0.4 -2.7 -1.2 -0.5 -1.1 -1.9 -1.5
Medication: Seretide 50 evohaler 0.3 0.3 3.0 0.4 0.2 -0.5 -0.3 -0.6 -0.4 0.0 0.2 -1.2 0.0 -0.8 -0.0 0.1 0.4 0.0 1.7 -0.8 0.2 0.7 0.1 0.4 0.2
Mean time to correctly identify matches 1.8 3.6 9.3 -3.0 1.5 2.6 1.8 1.9 2.8 0.7 1.6 2.8 1.4 2.0 2.1 0.9 1.8 1.7 -0.5 2.6 1.4 0.7 1.7 1.6 1.3
Heart disease (mother) 3.0 3.7 9.6 1.8 -1.8 -2.0 -1.8 -2.8 -3.1 -1.8 -1.4 -2.3 -1.8 -1.2 -1.9 -1.0 -1.8 -1.7 -0.6 -2.8 -1.6 -0.9 -2.1 -1.7 -2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.3 0.4 -0.5 -0.3 -1.1 -0.0 0.1 -0.4 -0.8 0.7 -0.7 -0.5 -0.5 -0.9 -0.9 -1.0 -0.6 -0.1 -0.4 -1.1 -0.9 -0.9 -0.7
Whole body fat mass 0.9 3.8 10.4 1.5 -1.6 -1.2 -3.2 -0.5 1.6 -2.2 -1.9 0.3 -1.9 -1.8 -1.7 -2.7 -3.0 -2.2 -2.0 0.3 -1.8 -2.2 -1.5 -2.8 -1.4
Leg fat mass (right) 0.9 3.6 10.2 1.5 -1.5 -1.4 -3.1 -1.0 1.1 -2.2 -1.8 -0.4 -1.8 -1.9 -1.7 -2.5 -3.2 -2.1 -1.7 -0.1 -1.9 -1.7 -1.4 -2.8 -1.2
Arm predicted mass (right) 0.9 4.5 11.5 -2.1 2.1 1.2 1.2 1.0 2.2 2.4 1.6 0.6 2.0 2.1 1.9 1.5 2.7 2.0 3.4 2.3 1.7 2.2 2.8 2.5 2.7
Pulse rate, automated reading 1.3 4.1 6.7 2.6 -1.9 -1.8 -1.5 -1.3 -0.1 -2.5 -2.4 -1.1 -2.4 -2.5 -2.0 -2.5 -2.3 -2.1 -1.9 -1.1 -2.0 -2.3 -2.5 -1.9 -2.0
Alcohol intake frequency. 0.4 0.9 4.1 0.1 -0.6 0.2 -1.0 0.8 2.0 -1.0 -0.7 1.3 -0.8 0.3 -0.2 -0.6 -1.8 -0.7 -1.3 0.3 -0.4 -1.5 -0.5 -1.0 -0.6
Comparative height size at age 10 3.2 17.8 24.8 -4.9 4.0 4.4 2.8 3.9 4.3 4.3 3.4 4.4 4.1 4.8 4.6 3.5 5.0 4.1 4.3 4.0 4.7 3.2 4.1 5.0 4.2
Number of full sisters 0.4 0.5 2.7 0.1 0.5 0.2 1.6 0.1 -0.4 0.3 0.7 -0.9 0.1 -0.0 0.3 1.5 -0.3 0.7 0.3 -0.9 0.4 1.0 0.5 0.6 0.1
Suffer from ‘nerves’ 7.7 12.3 25.0 3.9 -3.4 -3.8 -3.3 -3.8 -2.5 -3.2 -3.2 -4.1 -3.4 -3.8 -3.8 -3.2 -5.0 -3.7 -2.2 -3.6 -3.3 -2.4 -2.6 -4.4 -3.1
Overall health rating 1.0 2.1 10.9 1.2 -0.9 -0.3 -1.3 -0.6 0.5 -1.9 -0.7 -0.1 -1.2 -2.3 -0.9 -1.0 -3.3 -1.0 -1.7 -2.1 -1.1 -0.8 -1.3 -2.3 -1.5
Chest pain or discomfort 0.4 0.6 3.2 -0.9 0.1 1.2 -1.1 -0.0 0.2 -0.9 0.1 1.3 0.0 0.2 0.4 -0.1 -1.4 0.0 -1.8 -0.2 0.1 -0.0 -0.2 -1.1 0.3
Had major operations 0.4 0.4 1.1 1.0 -0.6 -0.5 -0.6 -0.6 -0.5 -1.0 -1.0 -0.8 -0.5 0.2 -0.6 -1.0 -0.2 -0.5 -0.3 -0.7 -0.8 -0.5 -0.5 -0.3 -0.7
Age at last live birth 3.9 5.7 9.3 -1.7 2.5 2.1 2.6 2.1 1.5 2.7 2.5 0.7 2.4 2.9 2.4 3.0 2.7 2.7 2.6 0.9 2.1 2.5 2.7 2.9 2.6
Family relationship satisfaction 2.5 3.1 5.0 1.2 -1.9 -1.9 -2.0 -1.8 -1.1 -2.0 -1.9 -1.4 -2.0 -1.7 -1.9 -1.8 -2.0 -1.9 -1.8 -0.6 -1.9 -1.7 -1.8 -2.2 -1.4
Leg pain on walking 1.1 1.4 3.3 1.0 -1.1 -0.5 -1.2 -0.6 -0.4 -1.5 -1.3 0.4 -0.9 -1.8 -0.9 -1.2 -1.4 -1.1 -1.6 -1.3 -1.0 -1.2 -1.6 -1.0 -1.5
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.2 6.2 2.5 -1.5 -1.5 -1.8 -0.2 -0.2 -1.7 -1.8 -1.6 -1.5 -1.4 -1.6 -1.6 -2.0 -1.5 -1.2 -0.6 -1.7 -1.3 -0.4 -1.6 -1.3
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.8 -0.9 0.6 0.4 0.5 -0.2 0.8 0.1 0.4 0.7 0.5 0.4 0.4 -0.5 0.2 0.3 0.2 0.7 0.4 0.5 -0.1 0.2 0.5
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 10.5 0.7 -0.3 -1.2 -0.4 -1.7 -3.2 0.0 0.0 -2.1 -0.0 0.3 -0.6 0.7 0.9 -0.3 1.6 -1.8 -0.5 0.5 -0.7 0.2 -0.3
Medication: Aspirin 4.0 5.2 9.4 2.0 -2.5 -2.5 -2.8 -2.2 -2.0 -2.2 -2.2 -1.9 -2.5 -1.8 -2.6 -2.5 -2.6 -2.3 -2.2 -1.2 -2.7 -1.6 -2.0 -3.1 -2.0
Supplements: Vitamin C 2.6 3.1 6.7 -1.1 1.7 2.1 1.7 2.6 1.5 1.8 1.3 2.3 1.7 1.6 2.0 1.6 1.7 2.0 1.5 1.9 1.6 1.0 1.5 2.0 2.0
Knee pain experienced in last month 0.3 0.5 3.0 0.2 0.2 -0.2 -1.1 0.3 1.1 -0.5 -0.2 -0.2 -0.2 -0.8 -0.3 -0.8 -1.7 -0.3 -0.7 -0.5 -0.1 0.1 0.2 -1.4 -0.5
Hypertension (Self-reported) 1.1 3.2 8.1 1.8 -1.7 -1.3 -2.3 -1.0 -0.8 -1.7 -1.4 -1.0 -1.9 -1.4 -1.7 -1.2 -2.8 -1.7 -2.3 -1.9 -1.9 -1.5 -1.7 -2.7 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.3 3.9 15.6 2.1 -1.4 -2.5 -1.5 -2.1 -2.2 -1.7 -1.0 -2.9 -1.7 -0.8 -2.0 -0.7 -2.7 -1.8 -0.4 -4.0 -1.3 -0.6 -1.9 -2.3 -1.9
Illnesses of father: Heart disease 0.8 1.1 2.4 0.8 -0.9 -1.1 -0.9 -0.9 -1.3 -1.6 -1.1 -0.8 -1.1 -1.3 -1.1 -1.1 -0.7 -0.9 -1.1 -1.2 -1.0 -0.8 -1.0 -1.1 -1.2
Illnesses of siblings: Diabetes 0.5 0.6 1.6 0.6 -0.9 -1.0 -1.3 -0.5 -0.2 -0.0 -0.7 -1.1 -0.8 -1.2 -0.9 -0.6 -0.8 -0.8 -1.0 0.4 -0.9 -0.6 -0.4 -0.8 -0.4
Smoking status: Previous 3.6 5.5 14.7 3.8 -2.1 -2.0 -1.9 -1.0 -0.6 -2.5 -2.1 -2.4 -2.4 -2.4 -2.4 -3.3 -3.6 -2.2 -1.5 -2.6 -2.3 -1.6 -1.4 -3.0 -1.8
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.2 4.9 -1.4 1.3 1.3 0.9 1.4 1.5 1.8 0.7 1.1 1.5 1.7 1.4 0.5 1.5 1.4 1.2 2.2 1.4 1.2 2.0 1.8 1.9
Whole body fat-free mass 1.8 10.7 16.6 -3.5 3.3 2.7 2.2 2.3 3.6 3.3 2.7 2.3 3.2 3.5 3.3 2.8 4.1 3.2 4.0 3.5 3.0 3.1 3.9 3.8 3.8
Leg fat-free mass (right) 1.7 9.4 19.3 -3.2 2.9 2.9 2.0 3.2 3.9 2.7 2.3 3.4 2.6 3.1 3.2 2.5 3.9 2.7 2.8 4.4 2.5 2.0 3.3 3.5 3.3
Arm fat percentage (left) 1.5 6.3 13.7 2.2 -2.3 -1.5 -3.1 -0.0 1.5 -2.9 -2.5 0.6 -2.6 -2.5 -2.2 -3.0 -3.7 -2.8 -3.7 0.2 -2.6 -3.2 -2.1 -3.5 -2.2
Average weekly red wine intake 3.5 5.2 10.8 -2.6 2.2 2.4 1.6 1.4 0.7 2.4 2.2 1.9 2.4 2.3 2.6 1.9 3.3 2.4 1.9 3.2 2.5 2.0 1.7 2.9 1.9
Handedness (chirality/laterality): Left-handed 1.3 1.5 4.6 -1.4 0.9 1.7 0.8 1.2 1.7 0.5 1.0 2.1 0.7 1.3 1.4 1.7 1.1 0.9 -0.1 2.0 0.8 0.3 1.0 1.2 1.0
Mood swings 6.2 11.4 30.4 3.8 -2.9 -3.5 -3.1 -3.3 -1.9 -3.4 -2.9 -4.1 -3.3 -3.8 -3.5 -2.4 -5.5 -3.3 -1.2 -4.3 -3.3 -1.9 -2.8 -4.1 -3.4
Loneliness, isolation 3.2 4.4 11.2 2.4 -2.0 -2.4 -1.5 -2.0 -0.8 -1.6 -2.3 -1.8 -1.9 -2.5 -2.2 -1.3 -3.3 -2.3 -0.8 -3.3 -1.9 -1.5 -2.0 -2.5 -2.1
Long-standing illness, disability or infirmity 1.2 1.9 8.3 1.1 -0.9 -0.8 -1.7 -1.1 -0.0 -1.2 -1.1 -0.5 -1.1 -1.6 -1.2 -1.7 -2.9 -1.0 -1.1 -2.2 -1.0 -0.7 -1.3 -2.2 -1.1
Ever had bowel cancer screening 0.5 0.6 3.0 1.7 -1.0 -0.6 -0.5 0.1 0.2 -0.8 -0.5 -0.7 -0.9 -0.4 -0.9 -0.2 -1.3 -0.5 0.0 -0.6 -0.9 -0.1 -0.1 -1.0 -0.8
Diabetes diagnosed by doctor 1.5 2.5 5.5 1.9 -2.1 -1.0 -2.1 -0.4 -0.6 -1.9 -2.0 0.1 -2.0 -0.9 -1.7 -1.6 -1.0 -1.4 -2.0 0.1 -2.4 -1.9 -1.6 -1.4 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 2.4 1.4 -1.5 -1.1 -1.1 -0.3 -0.6 -1.3 -1.5 -0.5 -1.3 -0.2 -1.3 -1.5 -0.4 -1.2 -1.4 -0.2 -1.2 -1.3 -0.2 -0.9 -1.0
Friendships satisfaction 2.2 2.7 6.4 2.4 -2.0 -1.6 -1.2 -0.6 0.5 -1.8 -2.5 -0.7 -2.0 -1.7 -1.8 -2.0 -1.7 -1.8 -1.0 -0.9 -2.1 -1.5 -1.3 -1.6 -1.6
Qualifications: nursing, teaching 2.1 3.3 9.0 -1.0 1.6 1.4 3.0 1.4 1.1 2.1 1.5 1.1 1.8 1.8 1.7 1.5 2.4 2.0 2.1 1.4 1.8 1.7 2.1 2.6 1.8
Commuting to job workplace: Walk 0.6 0.7 2.2 1.0 -0.8 -0.0 -0.9 -0.4 -0.9 -1.5 -0.6 -0.2 -1.0 -0.6 -0.5 -0.7 -0.7 -0.7 -1.0 -0.4 -1.0 -0.9 -1.2 -0.8 -0.5
Eye problems/disorders: Cataract 4.1 4.7 6.9 -2.1 2.2 2.6 1.7 1.7 1.7 1.9 2.2 2.5 2.2 2.3 2.6 1.9 2.4 2.6 2.4 2.0 2.3 2.1 1.4 2.6 2.1
Mouth/teeth dental problems: Mouth ulcers 2.1 3.3 10.6 -1.6 1.6 2.0 1.9 2.5 3.3 1.3 1.5 1.9 1.7 2.2 1.9 1.3 1.3 1.8 0.6 1.7 1.5 1.1 2.5 1.8 1.5
Medication for cholesterol 4.0 6.1 14.7 -1.8 2.2 2.5 2.5 2.6 1.6 2.4 1.8 2.8 2.4 2.4 2.6 1.9 3.8 2.4 2.4 2.8 2.1 1.7 2.1 3.8 2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.7 -0.5 0.9 0.3 0.7 0.9 0.5 0.9 0.8 -0.8 0.8 0.5 0.6 1.3 -0.0 0.9 1.4 0.5 0.9 1.6 1.6 0.5 1.0
Back pain experienced in last month 1.4 2.1 7.8 1.3 -0.7 -1.4 -1.9 -2.0 -1.5 -0.9 -0.4 -2.5 -0.6 -0.9 -1.2 -0.5 -2.5 -0.7 0.3 -2.8 -1.1 0.4 -1.0 -1.7 -1.2
Mineral and other dietary supplements 0.2 0.2 1.7 -0.4 0.0 -0.2 0.1 -1.3 -1.0 0.0 0.1 -0.1 0.1 -0.4 -0.0 0.1 0.2 -0.1 0.8 -0.3 -0.1 0.4 -0.8 -0.0 0.1
Breast cancer (self-reported) 0.2 0.2 1.1 -0.1 0.0 -0.4 0.2 0.2 0.5 0.1 0.3 -0.5 0.2 -1.0 -0.2 0.6 -0.6 -0.1 -0.1 0.3 0.3 0.3 0.7 -0.6 0.4
Asthma (self-reported) 1.2 2.3 5.9 1.9 -1.3 -1.8 -1.8 -0.8 0.1 -1.5 -1.5 -1.6 -1.7 -1.6 -1.6 -1.6 -2.4 -2.1 -0.9 -0.5 -1.1 -1.4 -0.4 -2.2 -1.0
Osteoporosis (self-reported) 0.4 0.4 1.8 0.3 0.3 0.4 0.3 1.2 1.3 0.2 0.1 0.4 0.1 1.0 0.3 -0.2 -0.8 0.5 -0.3 1.3 -0.2 0.4 1.3 -0.1 0.3
Osteoarthritis (self-reported) 0.9 1.2 2.9 -1.3 1.4 1.2 1.3 1.2 0.7 1.3 1.7 0.3 1.2 0.9 1.1 0.6 -0.6 1.4 0.2 -0.6 1.3 1.4 1.1 0.0 1.3
Medication: Aspirin 2.8 3.6 6.6 1.5 -2.0 -2.0 -2.6 -2.0 -1.5 -2.0 -1.8 -1.5 -2.2 -1.7 -2.1 -2.3 -1.9 -1.9 -1.7 -0.8 -2.3 -1.3 -1.7 -2.5 -1.7
Medication: Gliclazide 4.7 5.3 9.0 2.5 -2.9 -2.1 -3.0 -0.7 -0.1 -2.7 -2.9 -0.6 -3.0 -2.1 -2.6 -2.6 -1.4 -2.6 -2.4 0.2 -3.0 -2.9 -1.8 -2.2 -2.5
Illnesses of father: None of the above (group 1) 2.2 2.7 4.3 -1.3 1.7 1.7 2.0 1.8 2.0 2.0 1.8 1.1 1.8 1.8 1.8 1.5 1.0 1.8 1.3 0.8 1.7 1.8 2.1 1.5 1.4
Smoking status: Current 0.1 0.2 0.9 -0.7 0.5 0.2 0.2 -0.6 0.7 -0.3 0.4 -0.1 0.4 0.4 0.3 0.2 -0.9 0.2 -0.1 -0.6 0.3 0.4 0.3 -0.3 0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 2.5 -0.5 0.4 0.5 1.3 0.9 -0.1 0.2 0.5 0.5 0.7 0.7 0.3 0.9 0.5 0.3 -1.6 1.0 0.1 0.0 0.4 0.1 0.2
Whole body water mass 1.8 10.6 16.4 -3.5 3.3 2.7 2.2 2.3 3.5 3.3 2.7 2.2 3.2 3.5 3.3 2.8 4.0 3.2 4.0 3.4 2.9 3.1 3.8 3.8 3.8
Leg predicted mass (right) 1.7 9.4 19.7 -3.1 2.8 2.9 2.0 3.2 3.9 2.7 2.3 3.5 2.6 3.1 3.1 2.5 3.9 2.7 2.8 4.4 2.5 1.9 3.3 3.5 3.3
Arm fat mass (left) 0.4 1.6 4.0 0.8 -0.9 -0.6 -1.9 0.4 2.0 -1.3 -1.1 0.8 -1.1 -1.1 -0.8 -1.5 -2.0 -1.3 -1.6 0.9 -1.2 -1.5 -0.5 -1.8 -0.6
Number of self-reported non-cancer illnesses 2.8 4.9 14.9 2.5 -2.0 -1.9 -2.5 -1.5 0.2 -2.4 -2.1 -1.8 -2.0 -1.6 -2.2 -2.5 -3.9 -2.1 -1.8 -3.1 -2.0 -1.2 -1.4 -3.3 -2.0
Average weekly champagne plus white wine intake 1.0 1.4 4.5 0.8 -1.6 -1.8 -1.0 -2.1 -1.7 -0.7 -1.6 -1.8 -1.2 -0.9 -1.5 -0.3 0.9 -1.2 -0.0 -0.3 -1.0 -1.0 -0.7 -0.2 -1.0
Miserableness 2.6 4.5 8.3 2.6 -1.5 -1.9 -2.6 -1.8 -1.3 -2.5 -1.7 -2.5 -2.1 -2.9 -1.9 -1.4 -2.8 -1.8 0.0 -2.3 -1.9 -1.1 -2.8 -2.1 -2.7
Guilty feelings 11.1 16.8 33.0 5.1 -3.9 -4.1 -4.2 -3.4 -2.1 -4.4 -4.3 -3.7 -4.1 -3.4 -4.3 -4.6 -5.7 -4.1 -2.5 -4.9 -3.7 -3.1 -3.8 -4.7 -4.4
Wears glasses or contact lenses 0.5 0.6 4.8 0.8 -0.5 -1.0 -0.5 -0.7 0.2 -0.7 -0.3 -2.2 -0.7 -0.6 -0.7 -0.3 0.2 -0.2 0.7 -1.3 -0.5 0.3 0.1 -0.4 -0.9
Ever taken oral contraceptive pill 0.8 0.9 3.1 0.6 -0.6 -1.0 -0.3 -1.7 -1.0 -0.6 -0.5 -1.6 -0.5 0.6 -1.0 -1.0 -1.1 -0.8 -0.6 -1.8 -0.9 -0.2 -0.4 -1.1 -0.9
Hearing aid user 2.5 2.8 10.3 -1.9 1.5 1.9 1.3 2.0 3.2 2.1 1.7 2.3 1.5 0.8 1.7 1.6 0.6 1.3 -0.2 1.7 1.6 1.0 1.9 1.0 1.6
Mother’s age at death 0.3 0.3 1.4 -0.4 -0.0 0.0 -0.1 1.0 1.2 0.5 0.0 0.4 0.6 0.3 0.2 -0.7 1.1 0.4 0.4 0.8 0.7 0.2 -0.1 0.5 0.2
Financial situation satisfaction 1.4 1.8 5.1 2.1 -1.0 -1.3 -0.6 -1.4 -0.0 -1.5 -1.4 -1.7 -1.1 -1.8 -1.3 -1.4 -2.1 -1.0 0.0 -2.3 -1.0 -0.3 -0.8 -1.2 -0.9
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.3 -0.6 -0.0 0.4 0.4 1.1 0.8 0.7 0.5 1.1 0.0 0.8 0.3 0.8 -0.3 -0.0 -0.7 0.2 0.3 -0.3 0.0 -0.1 -0.2
Commuting to job workplace: Public transport 1.8 2.2 6.0 -0.7 0.8 1.2 1.3 2.4 1.2 2.1 1.3 1.2 1.1 -0.1 1.1 2.1 2.0 1.3 1.5 1.9 1.1 1.4 1.7 1.7 1.1
Eye problems/disorders: Glaucoma 1.6 1.9 4.9 1.8 -1.7 -1.0 -2.2 -0.6 -0.0 -1.0 -1.6 0.0 -1.4 -1.3 -1.3 -1.7 -1.4 -1.9 -0.7 -1.1 -1.1 -1.7 -1.6 -1.4 -1.7
Medication: Blood pressure 2.8 5.4 15.0 2.0 -2.3 -1.9 -2.4 -2.0 -1.6 -2.0 -1.6 -1.7 -2.3 -2.4 -2.3 -1.9 -3.9 -2.1 -2.4 -3.0 -2.3 -1.6 -2.2 -3.4 -2.3
Pain type(s) experienced in last month: Hip pain 0.7 0.8 4.8 0.8 0.1 -0.6 -0.8 -0.9 -1.1 0.4 0.4 -1.5 0.1 -0.9 -0.4 -0.2 -1.7 0.1 0.9 -2.2 0.2 1.0 -0.6 -1.0 -0.3
Supplements: Fish oil (including cod liver oil) 1.0 1.3 2.8 -1.4 1.0 0.9 1.2 1.0 0.7 1.6 1.3 0.7 1.2 1.2 1.0 1.0 1.0 1.1 -0.1 1.0 1.3 0.9 1.7 1.1 1.3
High cholesterol (Self-reported) 0.5 0.9 3.0 1.1 -1.0 -1.4 -0.9 -1.2 -0.3 -0.6 -1.0 -1.7 -0.8 -0.3 -1.1 -0.6 -1.1 -0.8 0.1 -1.5 -0.9 -0.2 -0.2 -1.1 -0.9
Medication: Bendroflumethiazide 2.1 3.2 8.9 0.6 -1.8 -1.6 -2.3 -1.4 -0.8 -1.6 -1.2 -0.9 -1.9 -1.6 -1.9 -1.6 -2.7 -2.0 -3.0 -0.1 -1.8 -1.5 -1.6 -2.9 -1.7
Medication: Paracetamol 3.1 4.9 9.3 2.4 -2.5 -2.1 -1.7 -1.4 -1.6 -2.3 -2.1 -1.4 -2.3 -2.5 -2.4 -2.7 -3.0 -2.3 -2.2 -1.9 -2.0 -1.8 -2.0 -2.5 -2.5
Medication: Lisinopril 0.2 0.3 1.3 0.2 -0.2 0.1 -1.2 -0.6 -0.8 -0.3 -0.2 -0.1 -0.0 0.5 -0.2 -0.7 -0.7 0.1 -0.4 -0.6 -0.3 0.6 -0.6 -0.8 -0.1
Medication: Atorvastatin 0.3 0.4 1.2 -0.3 -0.6 -0.6 -1.0 -1.1 -1.0 0.0 -0.4 -0.7 -0.5 -0.7 -0.7 -0.1 -0.1 -0.5 -0.2 -0.3 -0.6 -0.2 -0.6 -0.7 -0.4
Illnesses of father: High blood pressure 4.8 5.9 11.0 1.6 -2.4 -1.8 -2.9 -2.2 -2.0 -3.0 -2.4 -1.0 -2.6 -1.8 -2.4 -2.9 -2.6 -2.5 -3.3 -1.4 -2.8 -2.3 -2.9 -2.9 -2.5
Alcohol drinker status: Never 0.2 0.2 0.8 0.2 -0.5 -0.1 -0.5 -0.4 0.5 -0.7 -0.3 -0.3 -0.6 0.4 -0.2 0.1 -0.9 -0.5 -0.3 -0.6 -0.1 -0.9 -0.5 -0.3 -0.6
Ever smoked 1.6 2.9 8.5 2.3 -1.2 -1.7 -1.3 -1.6 -0.7 -2.3 -1.2 -2.8 -1.6 -1.3 -1.7 -1.9 -2.9 -1.5 -0.7 -1.8 -1.5 -0.6 -0.7 -2.3 -1.0
Basal metabolic rate 1.2 6.9 11.6 -2.9 2.7 2.3 1.4 2.0 3.4 2.5 2.1 2.1 2.5 2.8 2.7 2.0 3.1 2.5 3.2 3.2 2.3 2.3 3.1 2.9 3.1
Leg fat percentage (left) 4.0 14.8 33.9 3.9 -3.6 -3.5 -5.0 -2.8 -0.8 -4.2 -3.6 -2.5 -3.9 -4.1 -3.9 -4.4 -5.8 -4.1 -3.4 -2.5 -3.9 -3.4 -3.7 -5.3 -3.5
Arm fat-free mass (left) 1.0 5.1 11.0 -2.5 2.3 1.6 1.1 0.9 2.5 2.3 1.9 0.8 2.3 2.4 2.2 1.7 2.4 2.1 3.3 2.4 2.0 2.4 3.1 2.4 2.9
Number of operations (self-reported) 0.6 0.9 3.9 1.1 -0.6 -0.8 -0.9 -0.4 1.0 -1.3 -0.8 -1.5 -0.7 -0.3 -0.8 -1.1 -2.0 -0.7 -0.4 -1.0 -0.7 -0.2 0.8 -1.5 -0.4
Average weekly beer plus cider intake 0.9 1.3 3.0 0.9 -1.1 -1.4 -1.7 -1.2 -1.5 -1.2 -0.9 -1.2 -1.3 -0.9 -1.3 0.2 -1.2 -1.4 -0.6 -0.1 -1.3 -0.9 -1.3 -1.1 -1.3
Irritability 3.6 6.2 15.6 2.7 -2.4 -1.9 -3.0 -1.6 -0.3 -1.8 -2.4 -1.4 -2.4 -3.5 -2.4 -2.6 -4.0 -2.7 -2.4 -2.6 -2.3 -2.1 -2.2 -3.3 -2.3
Risk taking 0.6 1.0 2.1 -1.4 0.7 0.6 0.6 -0.8 -0.8 0.9 1.0 -0.0 1.0 1.0 0.7 0.9 1.5 1.3 1.3 0.7 1.1 1.0 0.8 1.3 1.0
Ever had prostate specific antigen (PSA) test 1.3 1.5 5.2 -1.3 0.8 1.2 1.1 1.4 1.4 1.4 0.8 1.1 0.8 0.9 1.2 1.1 2.3 1.2 0.8 1.5 0.9 0.6 1.5 1.7 0.9
Fractured/broken bones in last 5 years 2.8 3.6 8.5 -1.6 1.8 2.7 2.3 2.4 2.0 2.2 1.5 2.5 2.1 2.9 2.0 0.5 -0.1 2.0 -0.4 0.5 1.8 1.5 1.9 0.9 2.2
Age started oral contraceptive pill 0.9 1.1 4.1 -1.0 1.2 0.9 1.0 1.0 2.0 1.0 1.2 1.1 1.1 0.8 1.3 0.8 0.1 0.6 0.2 0.4 1.3 0.9 1.5 0.6 1.2
Diastolic blood pressure, automated reading 2.2 7.0 16.9 3.0 -2.5 -1.9 -2.9 -0.6 -1.5 -1.9 -2.7 -0.6 -2.9 -3.2 -2.6 -3.1 -3.3 -2.9 -4.1 -0.7 -2.8 -2.9 -2.8 -3.3 -2.1
Ever depressed for a whole week 2.0 2.5 7.3 1.2 -1.1 -1.4 -0.9 -2.6 -1.5 -2.5 -1.3 -2.2 -1.3 -0.7 -1.4 -1.2 -2.0 -1.4 -0.0 -2.7 -1.5 -0.9 -1.1 -1.5 -1.3
Unable to work because of sickness or disability 0.6 0.7 1.5 -0.7 1.1 1.1 0.9 0.8 1.2 0.2 0.8 0.8 0.9 0.8 1.0 0.8 -0.2 1.0 0.7 0.1 1.1 0.8 1.1 0.5 0.9
Commuting to job workplace: Cycle 0.7 0.9 3.9 -1.0 0.7 0.6 0.4 -0.9 -2.0 -0.1 1.2 -0.7 0.5 1.0 0.6 1.4 1.6 0.7 0.7 0.2 0.4 1.1 0.2 1.2 0.3
Myopia 0.2 0.2 1.4 -0.1 -0.2 -0.6 -0.5 -0.4 -1.1 0.2 0.2 -1.2 -0.4 0.2 -0.4 0.4 -0.4 -0.1 0.3 -0.4 -0.1 0.2 -0.3 -0.5 -0.3
Vascular/heart problems diagnosed by doctor 0.5 1.4 4.2 -0.7 1.1 0.8 1.6 0.8 0.5 1.0 0.8 0.7 1.3 1.1 1.1 0.4 2.1 1.1 1.9 1.5 1.3 0.8 1.0 2.0 1.0
Cholesterol lowering medication 0.7 1.0 4.6 1.1 -0.8 -1.4 -0.2 -0.7 0.3 -0.8 -0.6 -1.7 -0.6 -0.8 -1.0 -0.4 -1.6 -1.0 0.2 -2.1 -0.7 -0.3 -0.0 -1.4 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 6.6 1.3 -0.1 -0.5 0.5 0.4 0.0 -0.4 0.0 -0.4 -0.3 -0.4 -0.5 0.2 -1.9 -0.5 0.2 -2.6 -0.4 0.3 -0.6 -1.1 -0.7
Pain experienced in last month 0.7 1.2 8.2 -1.0 0.5 0.7 1.3 1.2 -0.4 1.4 0.4 1.3 0.8 1.0 0.9 0.4 2.9 0.6 0.1 1.6 0.6 -0.0 0.2 1.9 1.1
Supplements: Calcium 1.4 1.6 5.8 2.0 -1.1 -0.9 -1.0 0.5 -0.0 -1.2 -0.9 -0.6 -1.3 -1.2 -1.3 -0.5 -2.4 -1.2 -1.2 -1.1 -1.3 -1.2 -1.0 -1.9 -1.3
Basal cell carcinoma (self-reported) 2.4 2.9 6.2 -2.0 2.2 2.5 1.7 1.6 1.0 1.8 1.9 2.1 2.0 1.4 2.4 1.1 1.0 2.0 1.7 0.3 1.8 1.4 0.4 1.7 1.5
Heart attack/myocardial infarction (self-reported) 0.9 1.2 3.4 0.8 -0.8 -1.0 -1.7 -1.6 -1.5 -0.9 -0.9 -1.0 -0.9 -0.4 -0.9 -0.7 -1.1 -0.9 0.2 -1.8 -0.9 -0.4 -1.7 -0.8 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.6 -0.3 0.9 0.9 1.9 1.1 1.2 1.4 0.6 0.6 1.1 0.3 0.9 0.7 0.3 0.9 0.6 -0.5 1.1 0.9 0.9 0.9 0.8
Heart disease (siblings) 1.7 2.1 7.2 1.0 -1.5 -0.8 -1.7 -0.7 -1.5 -1.0 -1.3 0.9 -1.4 -0.4 -1.2 -1.3 -2.1 -1.6 -2.0 -0.6 -1.1 -1.8 -2.7 -1.6 -1.4
Alcohol drinker status: Previous 1.5 1.7 4.9 1.3 -1.3 -1.1 -1.4 -1.1 -0.5 -1.5 -1.5 -0.4 -1.4 -0.4 -1.3 -2.2 -1.7 -1.3 -0.8 -1.1 -1.4 -1.2 -1.4 -1.4 -1.3
Pack years of smoking 0.9 1.3 4.8 -0.7 1.5 0.8 0.8 0.6 0.9 0.9 1.4 0.1 1.2 0.8 1.3 1.3 1.0 1.3 2.2 -0.5 1.5 1.5 1.0 1.4 1.1
Impedance of whole body 1.3 6.8 13.9 2.8 -2.5 -2.0 -3.7 -1.9 -2.2 -2.5 -2.6 -1.3 -2.4 -2.7 -2.6 -2.7 -3.4 -2.7 -2.0 -2.5 -1.5 -2.6 -3.4 -3.1 -2.8
Leg fat mass (left) 0.8 3.1 9.3 1.6 -1.4 -1.3 -2.8 -0.7 1.2 -2.0 -1.6 -0.4 -1.7 -1.8 -1.6 -2.2 -3.0 -1.9 -1.5 -0.0 -1.8 -1.6 -1.2 -2.6 -1.2
Arm predicted mass (left) 0.9 4.4 10.9 -2.2 2.2 1.4 1.0 0.9 2.3 2.1 1.8 0.6 2.1 2.3 2.0 1.7 2.2 2.1 3.3 2.1 1.8 2.4 2.9 2.2 2.7