Hub : Genes

SEC22C

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1300	0.0370	2.7e-05	0.087	NA	0.043	NA	0.072	1.4e-07	NA	1.9e-04	NA	1.7e-06
2	GTEx	Adrenal Gland	0.2650	0.1083	7.3e-03	-0.006	NA	-0.006	NA	-0.006	6.1e-01	NA	6.0e-01	NA	6.2e-01
3	GTEx	Artery Tibial	0.0912	0.0360	3.2e-03	0.001	NA	-0.002	NA	0.001	2.8e-01	NA	4.6e-01	NA	2.4e-01
4	GTEx	Esophagus Mucosa	0.1210	0.0420	3.9e-04	0.054	NA	0.049	NA	0.047	1.7e-04	NA	3.3e-04	NA	4.1e-04
5	GTEx	Muscle Skeletal	0.2278	0.0433	1.0e-15	0.261	NA	0.230	NA	0.241	1.6e-25	NA	2.3e-22	NA	1.8e-23
6	GTEx	Thyroid	0.1040	0.0360	2.6e-04	0.086	NA	0.067	NA	0.074	4.1e-07	NA	7.1e-06	NA	2.4e-06
7	NTR	Blood	0.0199	0.0073	4.6e-04	0.004	0.006	0.005	0.006	0.006	1.1e-02	4.7e-03	9.8e-03	5.1e-03	3.4e-03
8	ROSMAP	Brain Pre-frontal Cortex	0.1423	0.0315	6.9e-12	0.143	0.107	0.119	0.136	0.152	5.8e-18	1.4e-13	4.4e-15	4.7e-17	5.0e-19
9	YFS	Blood	0.0289	0.0098	5.5e-05	0.007	0.011	0.013	0.011	0.013	1.9e-03	9.5e-05	2.9e-05	7.9e-05	4.0e-05
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0286	0.0187	8.3e-03	0.023	0.014	0.013	NA	0.021	1.1e-03	8.4e-03	1.1e-02	NA	1.7e-03
11	TCGA	Brain Lower Grade Glioma	0.1767	0.0477	0.0e+00	0.201	0.201	0.193	NA	0.202	2.1e-22	2.2e-22	1.8e-21	NA	1.6e-22
12	TCGA	Ovarian Serous Cystadenocarcinoma	0.0440	0.0250	6.0e-03	0.020	0.037	0.014	NA	0.023	1.6e-02	1.5e-03	3.4e-02	NA	1.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.9	1.5	3.0	-0.7	-0.1	1.1	-1.7	1.0	-1.7	-1.3	0.7	1.2	-1.5	1.2	1.2
Bipolar Disorder or Schizophrenia	0.3	0.7	2.1	0.6	-0.8	-0.3	0.8	-1.0	0.8	0.9	-1.4	0.1	-0.3	-1.0	-0.8
Depressed Affect (Nagel 2018)	0.1	0.2	1.1	-0.5	0.3	-0.4	-0.1	-0.1	-0.2	-0.1	-0.2	-0.9	-1.1	-0.1	0.2
Depression (Nagel 2018)	1.1	1.6	4.1	-0.5	-0.8	-1.3	1.3	-1.7	0.3	1.1	-2.0	-1.3	-1.9	-1.2	-0.5
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.8	-1.5	-0.0	-1.6	-0.2	-1.7	-0.5	-0.5	-1.3	-1.5	-0.9	-1.4	0.9
Neuroticism (Nagel 2018)	0.1	0.2	0.6	-0.7	0.7	-0.4	-0.1	-0.1	-0.3	-0.5	0.1	-0.3	-0.7	0.0	0.3
Schizophrenia (2018)	1.7	3.4	5.8	1.3	-0.7	-1.3	2.3	-2.1	2.4	2.2	-2.4	-0.8	0.8	-2.3	-2.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.2	0.5	-0.0	0.5	0.2	0.0	0.2	0.0	-0.4	0.4	0.2	-0.4
Worry (Nagel 2018)	0.3	0.6	2.2	-1.0	-0.2	-0.3	-0.8	0.4	-0.9	-1.5	0.5	0.1	-0.9	0.6	0.9
Alzheimer’s Disease (in mother)	1.0	1.2	3.4	-1.8	-0.3	-0.9	-0.5	0.0	-1.8	-1.6	-0.2	-0.7	-0.7	0.5	1.6
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.5	0.5	0.6	0.7	0.3	0.1	-0.7	0.2	0.1	0.6	0.5	-0.1
Alzheimer’s Disease (including proxy)	1.0	1.5	4.7	-1.2	0.7	0.4	-0.6	1.0	-2.2	-2.1	0.8	0.4	-0.5	1.4	1.5
Crohns Disease (2017)	0.3	0.6	1.6	0.8	0.9	-0.2	0.5	-0.1	1.2	1.2	0.4	0.4	1.0	-0.6	-1.1
Irritable Bowel Disease (IBD)	0.1	0.3	2.2	-0.0	1.5	-0.8	-0.2	-0.2	0.7	0.4	0.0	-0.4	0.4	-0.4	-0.5
Ulcerative Colitis (UC)	0.2	0.4	2.5	-0.5	1.6	-1.0	-0.2	-0.3	0.3	-0.1	-0.4	-0.7	-0.2	-0.2	-0.1
Major Depression (MDD)	0.3	0.4	1.7	-0.6	0.1	-0.1	-0.4	-0.7	0.0	-0.4	-0.8	-1.3	-0.5	-0.5	0.5
Reaction Time	1.0	1.9	4.4	1.3	1.7	-0.1	1.4	-1.0	1.8	2.0	-1.1	-0.2	1.3	-1.3	-2.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.3	-1.5	-0.1	-0.5	-0.8	-0.4	-1.2	-0.9	-0.2	-0.9	-0.8	-0.1	1.3
Breast Cancer	0.5	1.2	5.2	0.3	2.3	1.2	-0.5	1.3	-0.6	-0.5	0.9	1.6	0.3	1.3	-0.0
Ovarian Cancer	1.9	2.5	5.1	-1.3	-2.2	-1.8	-0.7	-1.8	-0.5	0.2	-1.7	-2.2	-2.2	-1.5	1.0
Prostate Cancer	2.3	3.3	7.0	2.6	0.1	1.6	2.1	1.4	1.6	1.9	0.9	2.1	2.2	0.8	-2.6
Age at First Birth	1.6	2.3	6.3	-0.0	1.4	1.4	-1.0	2.5	-1.1	-1.1	2.3	1.4	0.1	2.5	0.5
Bipolar Disorder (2011)	1.2	1.2	2.9	-1.0	-1.0	-1.0	-0.6	-1.7	-0.4	-0.5	-1.7	-0.2	-1.7	-1.4	0.3
Body Mass Index (BMI) (2010)	1.2	1.6	4.0	-0.6	-0.7	0.6	-1.4	1.7	-1.6	-1.8	1.3	0.3	-0.6	2.0	1.3
Coronary Artery Disease (CAD)	0.1	0.1	0.6	-0.3	0.3	-0.8	0.4	-0.1	0.1	0.3	-0.4	-0.6	-0.3	-0.2	0.2
Crohns Disease (2012)	0.5	0.8	2.2	0.9	0.4	-0.1	1.5	-0.0	1.3	1.0	0.4	0.7	0.7	-0.4	-1.4
Mean Putamen Volume	0.1	0.1	0.6	0.1	-0.3	0.8	0.1	0.2	-0.2	0.2	-0.1	0.8	-0.5	0.2	-0.1
Fasting Glucose	0.7	0.8	1.3	-1.0	-0.9	-1.1	-0.2	-1.1	-0.7	-1.1	-1.1	-0.9	-0.4	-0.8	1.0
HbA1C	0.2	0.2	0.8	0.7	0.9	0.6	0.5	0.3	0.1	-0.5	-0.0	0.1	0.7	0.5	-0.3
HDL Cholesterol	0.1	0.1	0.7	0.1	0.8	0.0	-0.4	0.3	0.0	-0.0	0.4	0.3	0.1	0.3	0.1
LDL Cholesterol	1.0	1.5	3.4	-1.0	1.1	0.5	-1.1	1.8	-1.4	-1.6	1.4	0.1	-0.9	1.8	1.0
Lupus	0.5	0.8	3.0	-0.6	-1.7	-0.1	-0.5	0.8	-1.0	-1.0	0.9	-0.2	-0.3	1.0	1.1
Neuroticism (2016)	0.8	1.1	2.2	-0.1	0.4	-1.4	0.9	-1.2	1.2	1.3	-1.3	-0.8	-0.4	-1.5	-1.1
Primary Biliary Cirrhosis	0.3	0.5	2.0	-0.4	-0.0	-1.4	0.5	-0.8	0.2	-0.1	-0.8	-1.0	-0.2	-0.8	0.1
Rheumatoid Arthritis	0.7	1.0	2.6	-1.4	-1.6	-0.7	-1.1	0.0	-1.1	-0.8	-0.1	-0.9	-1.4	0.2	1.2
Schizophrenia (2014)	0.4	0.9	2.3	1.2	-1.0	-0.3	1.5	-0.3	1.2	1.2	-0.5	-0.0	0.7	-0.5	-1.3
Triglycerides	0.1	0.1	0.9	0.3	0.3	0.2	0.9	0.2	0.2	0.1	0.0	0.1	-0.0	0.1	-0.3
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.1	0.3	-1.0	1.3	-0.1	1.8	-0.5	-0.6	1.5	0.7	0.4	1.7	0.2
Ulcerative Colitis	0.3	0.4	1.3	-0.8	0.9	-1.2	-0.1	-0.4	0.0	-0.0	-0.8	-1.1	-0.5	-0.2	0.1
Blood Eosinophil Count	1.4	10.9	25.7	2.4	-0.6	-0.9	4.8	-3.0	3.6	5.1	-2.9	-3.1	2.1	-3.8	-3.8
Blood Platelet Count	0.3	3.2	8.4	-1.4	-1.4	-2.7	-0.0	-2.9	0.5	0.0	-2.6	-2.3	-0.9	-2.4	0.5
Blood Red Count	0.2	1.6	3.5	-1.4	-0.7	0.1	-1.2	0.7	-1.8	-1.9	0.5	1.1	-1.5	1.2	1.6
Blood White Count	0.7	4.9	11.8	1.6	-1.4	-0.3	2.7	-2.5	2.4	3.4	-2.6	-1.4	0.3	-2.9	-2.3
Heel T-Score	0.3	2.4	5.3	-0.0	-1.6	-1.4	1.6	-2.3	0.9	0.9	-2.3	-2.2	-0.2	-2.2	0.1
BMI	1.1	6.5	13.2	0.6	-3.5	-3.0	2.3	-3.6	2.8	1.4	-3.0	-2.5	0.4	-3.5	-1.1
Height	0.1	2.8	21.7	-0.8	-0.4	-0.1	-4.7	0.6	-1.5	-1.1	0.5	-0.8	-1.9	0.8	1.5
Waist Hip Ratio (WHR)	1.2	5.5	15.9	-0.8	-0.9	-3.1	0.5	-3.8	1.4	1.3	-4.0	-2.8	-1.1	-3.4	-0.4
Systolic Blood Pressure	0.5	2.6	5.8	-2.0	-0.3	-2.0	-1.5	-1.7	-0.4	-0.5	-1.7	-2.4	-2.2	-1.4	1.3
Smoking Status	0.2	0.4	1.8	-0.7	-0.6	-0.5	-0.8	-0.2	-0.6	-0.4	-0.5	-0.3	-1.4	-0.1	0.5
Allergy or Eczema	0.8	2.2	5.1	2.1	1.7	0.7	1.9	-0.4	1.9	1.4	-0.1	0.7	2.3	-0.8	-1.9
Cardiovascular Disease	0.2	0.8	2.1	-1.1	-1.4	-1.1	0.6	-0.7	-0.6	-0.9	-0.6	-0.6	-1.2	-0.3	1.1
Hypothyroidism (self reported)	0.4	1.0	2.8	-1.3	-1.7	-0.7	-1.1	-0.5	-0.9	-1.2	-0.4	-0.1	-1.1	-0.2	1.4
Respiratory disease	0.2	0.4	1.8	-0.3	0.3	0.0	-0.6	0.7	-0.4	-1.3	0.5	-0.2	-0.6	1.0	0.2
Type 2 Diabetes (T2D) (2018)	2.3	4.3	11.2	-0.2	-1.6	-2.8	1.1	-3.4	1.8	1.1	-3.1	-2.0	-0.5	-3.2	-0.4
Lung FEV1/FVC ratio	0.0	0.2	1.0	0.6	-1.0	-0.0	0.0	-0.1	0.5	0.3	-0.0	-0.3	0.4	-0.2	-0.3
Lung FVC	0.5	2.4	5.8	2.0	0.2	2.4	0.2	2.0	0.6	0.4	1.8	2.2	1.6	1.6	-1.3
Neuroticism	0.1	0.2	0.6	-0.8	-0.3	-0.7	-0.3	-0.5	-0.2	-0.2	-0.5	-0.5	-0.6	-0.4	0.3
Chronotype (morning person)	0.3	0.7	2.2	1.2	0.8	0.3	1.2	-0.1	0.9	1.5	-0.3	0.2	0.8	-0.4	-1.0
Hair Pigment	0.2	5.1	8.3	2.9	2.6	2.7	0.9	2.3	1.5	2.1	2.1	2.7	2.7	1.4	-2.3
Tanning	0.2	2.5	5.1	0.1	0.4	2.2	-1.3	2.2	-1.7	-1.6	2.2	1.4	0.5	2.3	1.2
Hand grip strength (left)	0.1	0.4	1.3	1.1	0.8	0.8	-0.2	0.5	0.5	0.1	0.4	0.7	0.3	0.4	-0.9
Number of treatments/medications taken	1.2	2.2	10.1	1.5	-0.9	0.1	3.2	-1.0	1.8	0.9	-1.0	0.7	1.5	-1.0	-1.7
Average weekly spirits intake	0.5	0.7	4.0	0.6	0.0	-0.4	2.0	-0.5	0.9	1.0	-0.4	0.2	0.1	-0.7	-0.9
Sensitivity / hurt feelings	0.5	0.9	2.4	0.0	1.5	1.4	0.4	1.0	-0.3	-0.4	1.4	1.3	0.8	0.9	-0.1
Frequency of depressed mood in last 2 weeks	1.2	1.6	4.2	-1.0	-0.3	-1.5	1.1	-2.0	0.5	0.5	-1.9	-1.4	-1.2	-1.9	-0.1
Hearing difficulty/problems: Yes	0.1	0.2	0.5	-0.2	-0.7	-0.3	-0.6	-0.3	-0.2	-0.0	-0.6	-0.4	-0.3	-0.2	0.2
Relative age of first facial hair	0.1	0.2	1.5	-0.0	0.8	0.1	1.2	0.2	0.0	-0.0	-0.1	0.3	-0.1	0.2	-0.2
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.3	1.2	0.8	-0.1	1.8	-0.9	1.5	1.0	-0.6	0.6	0.8	-1.1	-1.3
Ever used hormone-replacement therapy (HRT)	1.8	2.2	3.5	-0.1	-1.5	-1.6	1.8	-1.7	1.6	1.6	-1.9	-1.3	0.3	-1.9	-1.3
Ever had hysterectomy (womb removed)	0.9	1.0	2.6	-0.8	-0.1	1.0	-1.0	1.1	-1.6	-0.2	0.8	0.6	-1.5	1.1	0.8
Systolic blood pressure, automated reading	0.8	2.2	4.3	-1.3	0.1	-2.0	-1.7	-1.9	0.1	-0.0	-2.0	-2.1	-1.6	-1.7	0.6
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.2	-1.5	-1.2	-1.3	-0.9	-0.2	-0.8	-0.9	-0.3	-1.2	-1.0	0.1	1.2
Angina	1.4	1.9	3.5	-1.8	-1.9	-1.7	-0.3	-1.0	-1.0	-1.2	-1.2	-1.7	-1.8	-0.5	1.4
Medication for hormone replacement therapy	1.2	1.4	4.7	-1.5	0.4	-1.9	-0.1	-1.0	-0.3	-0.2	-1.1	-1.5	-2.2	-0.8	0.5
Vitamin and mineral supplements	2.4	3.3	8.3	-1.8	-1.9	-2.7	-1.2	-2.1	-0.3	-0.2	-1.8	-2.9	-1.6	-1.8	1.3
Supplements: Zinc	3.6	4.0	8.7	-2.0	-0.7	0.1	-2.9	1.5	-2.7	-3.0	1.2	0.0	-1.9	2.2	2.6
Medication: Co-codamol	0.4	0.5	2.6	-0.7	-1.6	0.2	-0.6	0.5	-1.0	-0.4	0.3	0.2	-0.3	0.6	0.7
Medication: Metformin	0.9	1.2	3.5	-0.9	-1.1	-1.9	-0.0	-1.7	0.3	0.0	-1.4	-1.3	-0.5	-1.5	0.2
Diabetes (father)	0.7	0.8	4.7	-1.0	-2.2	-1.0	-0.5	-0.1	-0.5	-0.3	-0.0	-1.2	-0.9	0.1	0.7
Diabetes (mother)	0.9	1.1	3.9	-1.3	-0.5	-0.6	-1.2	-0.3	-1.4	-2.0	-0.3	-1.2	-0.5	0.3	1.6
Severe depression (siblings)	1.3	1.4	4.0	1.6	0.2	0.9	2.0	-0.0	1.5	1.3	0.2	0.5	1.7	-0.4	-1.5
Pack years adult smoking proportion	1.7	2.6	6.8	-0.2	-0.7	-1.6	1.2	-2.5	1.4	1.7	-2.4	-1.3	-0.2	-2.6	-0.7
Impedance of leg (right)	1.3	6.3	15.0	1.5	2.5	3.6	-1.0	3.9	-1.0	-0.0	3.5	3.0	2.0	3.3	-0.0
Leg fat-free mass (left)	0.7	3.7	8.5	-0.1	-1.7	-2.7	0.2	-2.9	1.6	0.8	-2.6	-2.6	-1.2	-2.7	-0.4
Trunk fat percentage	0.3	1.2	3.3	1.8	-1.4	0.0	-0.2	-0.7	1.8	1.5	-0.3	-0.1	0.8	-1.0	-1.4
Hand grip strength (right)	0.3	0.7	1.6	1.0	0.3	1.2	0.1	1.3	-0.1	-0.6	1.1	1.0	0.1	1.2	-0.2
Townsend deprivation index at recruitment	0.3	0.4	1.0	-0.2	1.0	-0.9	0.4	-0.9	0.6	-0.1	-0.6	-0.7	-0.2	-0.7	0.0
Current tobacco smoking	0.7	1.1	2.7	-0.1	-1.1	-0.6	0.3	-1.4	0.8	1.1	-1.6	-0.8	-1.4	-1.5	-0.6
Average weekly fortified wine intake	0.3	0.3	0.9	-0.7	1.0	0.2	-0.3	0.3	-0.6	-0.6	0.5	0.3	-0.9	0.4	0.7
Maternal smoking around birth	0.3	0.4	1.0	0.1	0.1	-0.9	0.8	-0.5	1.0	0.8	-0.3	-0.5	0.3	-0.7	-0.8
Fed-up feelings	0.3	0.6	1.5	-1.2	0.3	-0.4	-1.0	0.0	-0.7	-0.9	0.2	-1.0	-1.1	0.2	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.1	-0.9	0.3	-0.8	0.5	-0.9	-0.1	0.5	-1.0	-0.8	-1.4	-0.8	-0.1
Relative age voice broke	2.3	3.5	7.8	2.3	2.3	2.2	1.8	1.9	0.9	0.5	1.5	2.8	1.9	1.5	-1.7
Taking other prescription medications	0.8	1.3	5.6	0.6	-0.8	-0.6	2.4	-1.1	1.0	1.1	-1.3	-0.2	0.4	-1.1	-1.2
Age when periods started (menarche)	0.1	0.2	1.4	-0.0	1.2	0.3	0.4	0.4	-0.0	0.7	0.3	0.2	-0.4	0.2	-0.2
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	4.9	-2.0	-1.7	-0.5	-2.2	0.1	-2.2	-1.8	-0.1	-0.6	-1.6	0.6	2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	3.9	0.5	-0.2	-0.7	2.0	-1.0	1.3	1.0	-1.0	-0.7	0.0	-1.1	-0.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.2	0.3	0.2	-0.7	1.1	-0.9	0.5	0.6	-1.0	-0.4	0.7	-1.0	-0.3
Qualifications: CSEs or equivalent	0.3	0.4	1.7	0.3	0.5	0.8	-0.4	0.8	0.1	0.2	1.3	1.0	0.6	0.5	-0.3
Serious illness, injury or assault to yourself	0.8	1.0	3.7	1.1	-0.0	0.2	1.9	-1.1	1.2	0.6	-1.1	0.4	0.6	-1.0	-1.1
High blood pressure	0.3	0.7	1.6	-1.0	-0.7	-1.0	0.5	-1.3	-0.2	-0.7	-1.0	-0.8	-0.7	-0.9	0.9
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.6	1.9	1.8	0.7	1.8	-0.0	1.6	1.1	0.4	0.8	2.4	-0.4	-1.5
Multivitamins +/- minerals	3.4	4.3	12.7	2.1	2.5	3.1	1.4	2.2	0.4	0.6	1.9	3.6	1.7	1.8	-1.5
Stomach or abdominal pain in last month	0.4	0.5	1.5	0.3	-0.6	-0.1	1.1	-1.1	0.5	0.6	-0.6	-0.6	0.7	-1.2	-0.0
Supplements: Glucosamine	1.2	1.5	3.8	1.7	0.9	1.7	1.0	0.8	0.7	1.0	0.8	1.6	1.9	0.4	-1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.2	0.1	-0.2	-0.4	0.2	-1.0	0.6	0.2	-1.1	-0.8	-0.2	-0.8	-0.2
Medication: Atenolol	0.6	0.7	2.6	0.0	-1.0	-0.7	1.6	-0.9	0.7	0.8	-0.8	-0.6	-0.6	-0.9	-0.7
Medication: Levothyroxine sodium	0.3	0.5	1.6	-0.9	-0.5	-0.0	-0.5	-0.5	-0.8	-0.9	-0.7	0.5	-1.0	-0.2	1.3
Sitting height	0.3	2.1	12.5	-0.8	-1.5	-0.8	-3.5	0.1	-1.0	-1.3	-0.2	-1.2	-1.4	0.5	1.6
Chronic bronchitis/emphysema (father)	0.5	0.6	1.4	0.6	-0.0	-0.4	1.0	-0.9	1.2	0.8	-0.4	-0.3	0.9	-1.1	-0.6
High blood pressure (mother)	0.2	0.3	0.6	0.7	0.3	0.3	0.1	-0.7	0.3	0.5	-0.6	-0.8	0.6	-0.7	-0.2
Body mass index (BMI)	0.9	3.6	7.3	1.6	-1.6	-1.3	2.1	-2.5	2.7	1.6	-2.0	-1.0	0.8	-2.6	-1.9
Impedance of leg (left)	1.2	6.0	14.2	1.4	2.2	3.6	-1.2	3.8	-1.1	-0.3	3.5	3.0	2.0	3.3	0.1
Leg predicted mass (left)	0.7	3.8	8.6	-0.2	-1.7	-2.8	0.2	-2.9	1.6	0.7	-2.6	-2.7	-1.3	-2.7	-0.4
Trunk fat mass	0.3	1.3	3.2	1.5	-1.4	-0.6	-0.2	-1.2	1.8	1.3	-0.8	-0.7	0.3	-1.4	-1.2
Waist circumference	1.1	4.0	9.6	0.9	-1.6	-2.0	1.0	-3.1	2.4	1.5	-2.8	-1.8	-0.1	-3.0	-1.3
Number of incorrect matches in round	0.3	0.6	1.8	-0.1	-0.7	0.7	-1.4	0.7	-0.6	-1.2	0.3	0.5	-0.3	1.0	0.6
Past tobacco smoking	0.3	0.5	1.5	-0.3	-0.2	-0.3	0.4	-1.1	0.5	0.9	-0.9	-0.8	-0.5	-1.2	-0.2
Alcohol usually taken with meals	0.7	1.1	4.0	-0.5	0.9	0.5	-2.0	0.7	-1.4	-1.4	0.4	0.8	-0.4	1.0	1.3
Nervous feelings	0.1	0.2	0.6	-0.1	0.8	0.1	0.3	0.4	0.1	-0.8	0.8	0.1	-0.2	0.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	4.5	-1.6	-1.1	-1.9	-0.1	-2.0	0.1	-0.1	-2.0	-2.1	-1.7	-1.8	0.6
Hearing difficulty/problems with background noise	0.7	1.1	2.4	1.3	1.1	1.6	0.4	1.1	0.5	0.0	0.9	1.4	1.2	1.0	-0.7
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.2	-0.0	-0.5	-0.3	-0.1	0.3	-0.1	0.4	-0.0	0.5	-0.2	0.1
Had menopause	0.4	0.5	1.2	-0.9	-0.7	-1.0	-0.5	-0.7	-0.6	-0.5	-0.7	-1.1	-0.4	-0.5	0.9
Had other major operations	0.7	0.9	2.1	0.7	-0.5	-0.2	1.4	-1.2	1.2	1.0	-0.6	-0.1	1.2	-1.4	-0.6
Forced vital capacity (FVC)	0.5	1.8	5.2	0.6	-0.2	1.4	-1.7	2.2	-0.6	-0.6	2.3	1.1	0.1	2.0	0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.9	8.7	1.2	-0.3	-1.2	2.9	-1.6	2.4	2.0	-1.5	-0.9	1.0	-1.9	-1.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.1	0.4	-1.0	1.0	-0.5	0.2	-0.2	0.2	0.5	0.3	0.7	0.0	0.2
Qualifications: None of the above	0.1	0.2	0.7	0.4	0.8	0.5	-0.4	0.9	0.0	0.4	0.3	0.2	-0.2	0.7	-0.4
Financial difficulties in last 2 years	1.6	2.1	6.2	-0.8	0.0	-2.1	0.5	-2.1	1.3	0.6	-1.7	-2.5	-1.1	-1.9	-0.2
Mouth/teeth dental problems	1.6	2.4	5.7	-1.5	1.3	0.0	-2.2	1.3	-2.2	-1.5	1.0	-0.4	-2.4	1.6	1.6
Heart attack	0.1	0.1	0.6	0.5	0.2	-0.1	0.8	-0.2	0.0	-0.0	-0.7	-0.1	-0.1	-0.0	-0.0
Allergy	1.0	2.3	4.8	-2.2	-1.7	-0.6	-2.2	0.2	-2.0	-1.3	-0.1	-0.8	-2.1	0.6	2.1
Pain all over the body in last month	0.6	0.6	1.0	0.5	-0.8	-0.9	0.8	-0.9	1.0	0.9	-0.9	-0.6	0.2	-1.0	-0.6
Diabetes (self-reported)	0.5	0.8	2.1	-0.6	-0.5	-1.4	-0.2	-1.4	0.4	0.0	-1.2	-1.2	-0.1	-1.3	0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.5	-0.2	-0.6	-1.4	0.8	-1.3	0.8	1.4	-1.3	-0.9	-0.1	-1.6	-1.0
Medication: Ramipril	0.5	0.6	2.5	-1.0	0.0	0.0	-1.0	0.0	-0.8	-1.6	0.1	0.3	-0.9	0.4	1.0
Medication: Simvastatin	0.1	0.2	1.1	0.1	-1.0	0.3	0.1	-0.1	0.1	-0.3	-0.2	0.3	-0.7	0.0	-0.1
Fluid intelligence score	0.6	1.2	4.5	-1.4	-0.2	0.0	-1.2	0.1	-1.6	-1.6	0.6	-0.8	-0.7	0.4	2.1
Illnesses of siblings	0.9	1.3	2.8	-1.2	0.7	0.3	-1.3	1.4	-1.7	-0.8	1.4	0.5	-1.0	1.3	1.4
Neuroticism score	0.1	0.2	0.6	-0.8	0.6	-0.5	0.1	-0.6	0.1	-0.1	-0.3	-0.4	-0.2	-0.6	0.3
Weight	0.6	3.0	6.2	1.4	-1.5	-1.6	0.8	-2.4	2.4	1.5	-2.0	-1.3	0.2	-2.5	-1.4
Impedance of arm (right)	0.4	1.7	6.7	0.1	1.9	1.1	-2.6	1.6	-0.5	0.3	1.5	1.2	0.8	1.2	0.1
Arm fat percentage (right)	0.7	2.8	6.8	1.7	-1.1	-1.0	1.1	-1.9	2.6	1.9	-1.4	-0.7	1.2	-2.2	-2.0
Trunk fat-free mass	0.4	2.2	5.6	-0.1	-1.0	-2.2	0.7	-2.4	1.0	0.1	-2.1	-1.8	-1.1	-2.0	-0.1
Hip circumference	0.4	1.8	4.0	1.2	-1.6	-1.3	0.7	-1.7	2.0	1.3	-1.3	-0.9	0.2	-1.9	-1.2
Time employed in main current job	0.9	1.1	6.3	1.1	2.5	0.6	-0.7	0.7	0.4	-0.0	0.5	1.7	0.4	0.6	-0.6
Alcohol intake versus 10 years previously	1.0	1.5	3.5	-0.5	-0.4	1.3	-1.0	1.8	-1.5	-1.0	1.5	1.2	-0.8	1.9	1.1
Father’s age at death	0.2	0.3	0.8	-0.4	0.9	0.2	0.2	0.4	-0.7	-0.3	0.1	-0.0	-0.7	0.5	0.7
Worrier / anxious feelings	0.8	1.6	3.6	-0.2	1.4	1.5	-0.3	1.4	-1.2	-1.7	1.6	1.9	-0.1	1.5	0.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	6.1	1.2	1.3	0.3	2.5	-1.0	1.9	1.3	-0.7	-0.2	1.4	-1.3	-1.5
Falls in the last year	0.3	0.4	1.2	0.5	-0.7	0.8	0.5	0.7	-0.0	-0.2	0.6	1.1	0.6	0.8	-0.0
Hair/balding pattern: Pattern 3	0.4	0.7	2.0	-0.6	-1.4	0.4	-0.5	0.7	-1.1	-1.1	0.2	0.4	-0.6	1.0	0.7
Number of live births	1.3	1.8	3.3	1.3	1.2	1.7	1.3	1.8	-0.1	0.3	1.7	1.6	1.7	1.6	-0.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.3	1.7	-0.1	1.7	-0.6	2.1	0.5	0.4	2.1	1.5	1.1	1.6	-0.7
Pulse rate	0.5	0.8	1.6	-1.2	-0.7	-1.3	-0.6	-0.8	-0.3	-0.6	-0.8	-1.1	-1.3	-0.4	0.9
Happiness	0.4	0.5	1.5	0.9	0.2	0.4	0.5	-0.3	1.2	1.1	-0.2	0.1	1.2	-0.6	-0.7
Noisy workplace	2.1	2.6	6.6	0.7	1.1	2.1	-1.1	2.4	-1.1	-1.2	2.0	2.2	0.4	2.6	0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.9	-0.7	1.0	0.1	-0.7	0.3	-0.6	-0.3	0.4	-0.0	-0.3	0.3	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.7	0.1	1.3	0.1	0.2	-0.3	0.2	-0.0	0.0	0.1	0.5	-0.4	0.0
Mouth/teeth dental problems: Dentures	0.6	1.1	3.1	1.2	-1.0	-0.1	1.8	-0.6	1.4	0.7	-0.3	0.4	1.5	-0.8	-1.2
Asthma	0.7	1.5	3.3	0.8	1.0	1.5	0.4	1.6	-0.4	-1.5	1.7	1.4	0.4	1.8	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.7	-0.2	0.1	-1.0	0.9	-1.4	0.3	0.2	-1.6	-0.9	-0.2	-1.2	-0.3
Medication: Cholesterol lowering	0.2	0.3	0.7	0.8	-0.8	0.4	0.7	-0.5	0.8	0.3	-0.6	0.3	0.1	-0.5	-0.7
Depression (self-reported)	0.4	0.5	2.4	-1.1	-0.1	-1.0	-0.3	-0.7	-0.4	-0.3	-0.8	-0.2	-1.5	-0.5	0.5
Medication: Lansoprazole	0.3	0.3	1.3	1.0	0.7	0.5	0.6	0.3	0.4	0.1	0.4	0.1	1.1	0.3	-0.4
Prospective memory result	0.9	1.1	3.2	0.7	-0.9	-0.8	1.3	-0.6	1.6	1.8	-0.9	0.0	0.7	-0.9	-1.4
Lung cancer (father)	0.4	0.5	2.4	-0.8	-1.5	-0.8	0.2	-0.0	-0.4	-0.3	0.2	-1.0	-0.3	0.0	0.7
Illnesses of mother	0.9	1.1	3.2	1.0	0.8	0.0	1.6	-0.2	1.8	1.7	0.1	0.4	0.8	-0.7	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	6.6	2.6	-0.1	2.0	0.4	2.0	1.4	1.2	2.1	1.8	2.2	1.4	-1.3
Pulse wave Arterial Stiffness index	1.1	1.3	2.8	-0.4	-1.7	0.8	-1.2	1.0	-1.5	-1.4	0.9	1.2	-0.6	1.3	1.2
Impedance of arm (left)	0.4	1.8	7.8	-0.1	1.3	1.3	-2.8	1.8	-0.9	0.3	1.7	1.0	0.4	1.4	0.5
Arm fat mass (right)	0.9	3.7	7.8	1.7	-1.7	-1.5	1.4	-2.4	2.8	2.1	-2.0	-1.0	0.8	-2.6	-2.0
Trunk predicted mass	0.4	2.0	5.2	-0.2	-1.0	-2.1	0.6	-2.3	0.8	0.0	-2.1	-1.8	-1.2	-1.9	-0.0
Standing height	0.1	0.7	6.3	-0.1	0.1	-0.6	-2.5	0.2	-0.4	-0.2	0.0	-0.6	-1.1	0.2	0.7
Length of working week for main job	3.6	4.0	7.0	0.3	2.4	-2.4	0.8	-2.3	2.1	2.5	-2.5	-1.8	-0.0	-2.6	-1.9
Exposure to tobacco smoke at home	0.2	0.2	0.9	-0.6	-1.0	-0.2	0.1	0.0	-0.3	0.4	-0.2	-0.5	-0.7	0.0	0.2
Breastfed as a baby	0.2	0.2	0.8	0.5	0.5	0.3	0.0	0.5	-0.2	0.2	0.2	0.8	-0.9	0.5	-0.3
Tense / ‘highly strung’	1.1	1.9	4.4	-0.8	0.2	-1.8	0.3	-2.1	0.9	0.9	-2.0	-2.0	-0.2	-2.1	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	4.9	-1.0	-1.1	-2.0	0.4	-2.0	0.6	0.9	-2.2	-2.0	-1.5	-1.9	-0.2
Hair/balding pattern: Pattern 4	0.1	0.1	0.5	0.0	-0.2	-0.7	-0.1	-0.3	0.5	0.1	-0.2	-0.7	-0.2	-0.3	-0.3
Birth weight of first child	0.5	0.9	1.5	-0.8	-1.1	-1.0	-0.9	-1.2	-0.5	-1.2	-1.1	-1.1	-0.8	-0.7	0.9
Peak expiratory flow (PEF)	0.6	1.3	3.5	1.8	-0.5	0.3	1.1	0.2	1.7	1.6	0.2	0.7	1.3	-0.2	-1.9
Pulse wave reflection index	0.3	0.4	1.3	1.0	0.2	0.7	0.7	-0.1	0.4	0.3	-0.1	1.1	1.1	-0.2	-0.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	2.1	0.3	-1.5	0.3	0.6	-0.3	0.6	0.4	-0.0	0.2	0.8	-0.4	-0.5
Loud music exposure frequency	0.9	1.0	2.0	-0.6	-0.3	0.8	-0.3	1.3	-1.3	-1.3	1.1	1.1	0.3	1.4	0.8
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	-0.4	-0.0	0.2	-0.2	-0.1	-0.2	-0.4	0.4	0.4	-0.5	-0.1	0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.5	0.8	1.2	0.4	0.1	-0.2	0.6	0.3	-0.4	0.7	0.6	-0.2	-0.6
Blood clot in the leg (DVT)	2.1	2.7	5.5	1.0	0.1	-1.2	2.0	-2.3	2.0	1.8	-2.1	-0.7	0.9	-2.4	-1.6
Medication: Paracetamol	3.1	5.1	16.1	1.9	-0.2	-0.8	4.0	-1.5	3.1	3.0	-1.7	-0.5	1.7	-2.1	-3.0
Headache pain in last month	0.2	0.4	1.0	-0.8	0.1	-0.8	0.0	-1.0	0.3	-0.0	-0.8	-0.7	-0.7	-0.9	0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.6	-0.1	1.3	-0.4	-0.7	0.6	-0.1	0.5	0.5	-0.7	0.3	0.2	-0.2
Glaucoma (self-reported)	0.3	0.4	1.6	0.6	0.4	1.3	0.5	0.7	-0.2	0.4	0.4	0.7	0.6	0.5	-0.5
Gout (self-reported)	0.7	0.9	3.4	1.3	-0.1	1.8	0.1	0.7	-0.1	0.3	0.5	1.9	0.8	0.7	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.4	-0.6	-0.6	-0.1	-0.7	-0.1	-0.7	-1.2	-0.1	0.5	-0.4	0.2	1.1
Medication: Amlodipine	0.2	0.3	1.6	-0.2	0.4	-0.1	0.2	-0.6	0.1	-1.3	-0.5	1.0	0.0	-0.2	0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.6	0.2	0.8	0.3	0.2	-0.1	-0.1	-0.4	-0.2	0.1	-0.2	0.0	-0.3
Birth weight	0.1	0.2	1.1	0.2	-0.1	-0.2	-0.1	0.2	-0.2	-1.1	0.2	0.4	-0.5	0.5	0.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.2	-0.5	0.9	0.6	-1.1	0.8	-0.9	-1.5	1.1	0.2	-0.5	1.0	0.9
High blood pressure (siblings)	0.4	0.6	1.4	1.2	-0.7	1.1	0.5	0.2	0.7	0.4	-0.2	0.9	1.1	0.2	-1.0
Forced vital capacity (FVC), Best measure	0.7	2.5	6.9	1.7	-0.0	1.9	-0.7	2.5	0.4	0.3	2.6	1.7	1.4	2.0	-0.4
Body fat percentage	0.4	1.6	4.5	2.1	-1.0	0.1	0.4	-0.8	2.1	1.6	-0.4	-0.0	1.2	-1.1	-1.7
Leg fat percentage (right)	0.5	1.7	5.5	2.3	-0.3	0.5	1.2	-0.6	2.1	1.4	-0.2	0.3	1.5	-0.9	-1.7
Arm fat-free mass (right)	0.4	1.9	3.9	0.3	-1.8	-1.8	1.0	-2.0	1.1	0.3	-1.8	-1.8	-0.9	-1.8	-0.3
Exposure to tobacco smoke outside home	0.2	0.2	1.1	0.4	-1.0	0.3	0.3	-0.6	0.1	-0.0	-0.3	-0.3	0.6	-0.6	0.5
Comparative body size at age 10	0.7	1.9	4.0	0.1	-0.4	-1.8	1.4	-1.8	1.4	1.3	-2.0	-1.1	-0.5	-1.8	-1.2
Number of full brothers	1.8	2.3	7.2	-1.7	-1.6	-2.0	-0.2	-1.5	-0.3	0.0	-1.5	-2.7	-1.8	-1.2	1.0
Worry too long after embarrassment	0.5	0.8	2.3	0.7	1.5	0.1	0.9	0.5	0.9	0.5	0.8	1.0	1.3	0.2	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.3	0.6	1.1	-0.6	1.5	-0.9	1.5	1.4	-1.0	-0.4	1.1	-1.1	-1.1
Wheeze or whistling in the chest in last year	0.2	0.3	1.2	0.5	1.1	0.7	0.4	0.4	0.4	-0.6	0.4	0.2	-0.5	0.5	-0.4
Number of children fathered	0.5	0.6	1.9	0.5	-0.6	1.4	-0.6	1.1	-0.7	-0.2	0.9	0.8	-0.4	1.1	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	-0.6	0.3	-0.3	0.0	0.7	-0.6	-0.5	0.7	0.4	-0.0	0.7	0.3
Age at first live birth	2.6	4.7	11.2	1.5	1.4	3.4	-0.2	3.3	-0.6	-0.6	3.0	3.0	1.5	3.0	-0.3
Pulse wave peak to peak time	1.2	1.4	3.0	0.7	1.7	-0.7	1.1	-0.9	1.6	1.6	-0.8	-1.1	0.9	-1.3	-1.3
Health satisfaction	0.4	0.5	2.1	-0.1	-0.2	-0.2	-0.1	-1.4	0.6	0.3	-1.0	-0.7	-0.3	-1.3	0.1
Shortness of breath walking on level ground	0.4	0.5	2.1	-0.0	-1.5	-0.7	-0.3	-0.9	0.6	0.3	-0.6	-0.6	-0.6	-0.8	0.0
Qualifications: College or University degree	0.3	0.8	1.9	-1.4	-0.8	-0.9	-1.4	-0.5	-0.9	-0.6	-0.5	-0.6	-0.8	-0.4	1.3
Eye problems/disorders: None of the above	0.4	0.5	1.9	0.5	0.4	1.1	-0.2	0.7	0.0	0.0	0.9	0.9	1.4	0.5	-0.4
Mouth/teeth dental problems: Loose teeth	1.7	2.1	5.2	0.1	-2.3	-1.0	1.2	-2.0	0.8	1.3	-2.1	-1.3	0.3	-2.0	-0.5
Emphysema/chronic bronchitis	0.9	1.0	3.1	-1.0	-0.4	-1.2	-0.6	-1.3	-0.4	-0.3	-1.3	-1.2	-1.8	-0.9	0.4
Medication for pain relief, constipation, heartburn	2.5	4.2	14.0	-1.3	0.2	1.3	-3.7	2.0	-2.5	-2.2	2.2	0.9	-1.2	2.3	2.4
Neck or shoulder pain in last month	0.1	0.1	0.5	-0.3	0.2	-0.3	0.2	-0.2	-0.0	-0.5	-0.0	-0.7	0.4	-0.1	0.4
Medication: Blood pressure	0.5	1.0	3.0	-0.6	-0.6	0.8	-0.3	0.6	-1.1	-1.7	0.6	1.0	-1.3	1.1	1.1
Angina (self-reported)	1.6	2.1	3.8	-2.0	-1.9	-1.8	-0.6	-1.0	-1.1	-1.2	-1.2	-1.8	-1.9	-0.4	1.5
Migraine (self-reported)	1.1	1.4	4.8	1.3	0.3	0.9	2.2	0.6	1.0	0.7	0.8	1.9	1.3	0.2	-1.3
Medication: Ibuprofen	1.4	1.6	4.7	-0.3	-0.4	-1.5	1.3	-2.0	0.7	0.7	-2.2	-1.3	-0.1	-1.9	-0.5
Medication: Allopurinol	0.4	0.5	2.2	0.4	0.0	1.5	-0.5	0.4	-0.8	0.1	0.2	1.4	0.4	0.4	0.0
Medication: Omeprazole	1.2	1.5	3.6	0.3	-1.9	-1.0	1.2	-1.4	1.3	1.1	-1.3	-1.1	0.9	-1.6	-0.7
Medication: Seretide 50 evohaler	0.2	0.2	0.6	-0.4	0.3	0.1	0.1	0.2	-0.3	-0.8	0.5	0.4	-0.6	0.4	0.3
Mean time to correctly identify matches	1.0	1.9	4.9	1.6	1.7	0.6	1.6	-0.3	1.5	1.9	-0.6	0.9	1.5	-0.7	-2.2
Heart disease (mother)	0.4	0.5	1.0	0.6	0.3	0.9	-0.7	0.8	-0.4	-1.0	0.8	0.4	0.7	1.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	5.8	-0.8	-0.1	1.1	-1.7	2.2	-2.2	-1.6	1.8	0.4	-0.9	2.4	1.5
Whole body fat mass	0.4	1.9	5.0	1.8	-1.3	-0.6	0.6	-1.4	2.2	1.6	-1.0	-0.6	0.8	-1.7	-1.6
Leg fat mass (right)	0.6	2.3	6.2	2.3	-1.1	-0.3	1.3	-1.4	2.5	1.6	-1.0	-0.5	1.1	-1.6	-1.8
Arm predicted mass (right)	0.5	2.5	5.2	0.0	-2.1	-2.0	0.7	-2.3	1.0	0.2	-2.1	-2.0	-1.3	-2.0	-0.0
Pulse rate, automated reading	0.4	1.3	3.1	-1.4	0.1	-1.1	-0.7	-1.2	-0.4	-1.8	-1.1	-0.6	-1.7	-0.5	1.4
Alcohol intake frequency.	0.1	0.3	1.7	-0.4	-1.3	-0.2	-0.4	-0.3	-0.1	0.1	-0.5	-0.2	-0.7	-0.2	0.2
Comparative height size at age 10	0.3	1.6	8.6	-0.8	-0.1	-0.6	-2.9	0.7	-1.2	-1.7	0.5	-0.4	-0.9	1.1	1.2
Number of full sisters	0.6	0.7	2.2	1.1	0.7	0.8	1.5	0.6	0.8	0.8	0.3	0.7	1.1	0.4	-0.9
Suffer from ‘nerves’	0.1	0.1	0.7	-0.2	0.4	0.1	0.3	-0.1	0.0	-0.8	0.2	0.4	-0.4	-0.0	0.3
Overall health rating	0.9	1.9	6.0	1.1	-0.1	-0.3	2.4	-1.8	2.0	0.8	-1.4	-0.2	0.8	-1.8	-1.3
Chest pain or discomfort	1.2	1.8	3.6	1.1	0.8	-0.4	1.9	-1.6	1.9	1.0	-1.4	-0.5	1.3	-1.6	-1.5
Had major operations	1.2	1.4	2.5	0.2	-1.6	-1.6	1.0	-1.5	1.3	0.6	-1.0	-1.0	1.2	-1.6	-0.2
Age at last live birth	2.7	3.9	8.6	1.5	0.8	2.9	0.1	2.9	-0.3	-0.8	2.8	2.8	1.6	2.8	-0.1
Family relationship satisfaction	0.5	0.6	1.4	-0.0	0.8	1.0	-0.4	0.6	-0.4	-0.7	0.9	1.0	1.2	0.7	0.6
Leg pain on walking	2.7	3.4	8.0	1.8	1.1	-0.1	2.8	-1.4	2.6	2.5	-1.5	0.1	1.5	-1.8	-2.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.1	1.3	0.9	0.8	1.5	-0.0	1.1	0.6	0.2	0.5	1.3	-0.2	-1.0
Commuting to job workplace: Car/motor vehicle	1.9	2.2	4.4	2.1	0.9	1.8	1.0	1.6	1.1	0.9	1.4	2.1	1.5	1.1	-1.7
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.6	0.1	-0.8	1.1	-1.0	1.9	-0.9	-0.9	1.5	1.4	-0.2	1.9	0.3
Medication: Aspirin	0.2	0.3	0.9	-0.5	0.3	-1.0	0.6	-0.5	0.2	0.0	-0.4	-0.7	-0.8	-0.4	-0.1
Supplements: Vitamin C	0.9	1.0	2.8	-1.5	-1.2	-1.7	-0.6	-0.6	-0.6	-0.6	-0.4	-1.5	-0.6	-0.4	1.2
Knee pain experienced in last month	1.3	2.1	4.9	1.5	-0.6	-0.2	1.7	-1.9	2.2	1.0	-1.8	-0.2	0.9	-1.8	-1.6
Hypertension (Self-reported)	0.2	0.5	1.0	-0.8	-0.5	-0.8	0.6	-1.0	-0.3	-0.8	-0.9	-0.4	-0.6	-0.6	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.3	0.9	0.1	0.3	0.9	-0.3	1.1	1.2	-0.4	-0.3	0.8	-0.5	-1.1
Illnesses of father: Heart disease	3.4	4.6	10.4	1.1	3.2	3.1	-0.6	2.7	-0.4	-1.1	2.5	3.1	1.6	2.6	-0.6
Illnesses of siblings: Diabetes	1.4	1.7	3.0	1.0	-0.3	-0.8	1.5	-1.7	1.7	0.9	-1.6	-0.8	1.4	-1.7	-1.1
Smoking status: Previous	0.7	1.0	2.5	-0.3	0.3	0.3	-1.0	1.4	-1.0	-1.5	1.5	0.5	0.4	1.6	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	1.0	0.6	0.6	-0.3	0.6	0.9	0.7	0.8	0.3	0.5	0.4	-0.3
Whole body fat-free mass	0.5	3.1	7.5	-0.2	-1.5	-2.5	0.6	-2.7	1.3	0.4	-2.5	-2.3	-1.2	-2.4	-0.2
Leg fat-free mass (right)	0.7	3.9	9.0	-0.5	-1.8	-2.9	-0.1	-3.0	1.4	0.4	-2.6	-2.7	-1.5	-2.7	-0.1
Arm fat percentage (left)	0.6	2.3	5.5	1.7	-1.5	-0.7	0.9	-1.7	2.3	1.8	-1.2	-0.7	0.9	-2.0	-1.7
Average weekly red wine intake	0.3	0.4	1.9	0.2	-1.4	-1.0	0.1	-0.6	0.1	0.1	-0.7	-0.7	0.1	-0.5	-0.0
Handedness (chirality/laterality): Left-handed	1.3	1.5	3.4	-0.5	1.1	0.8	-1.0	1.7	-1.6	-1.3	1.6	1.3	-0.0	1.8	0.7
Mood swings	1.3	2.4	7.0	1.5	1.7	-0.1	2.6	-1.0	2.1	1.8	-1.0	0.5	1.3	-1.4	-1.9
Loneliness, isolation	0.3	0.3	1.1	-0.6	-1.1	-0.2	-0.2	-0.6	-0.2	0.0	-0.6	-0.5	-0.9	-0.5	0.7
Long-standing illness, disability or infirmity	2.1	3.2	6.2	0.8	-0.6	-1.5	2.2	-2.4	2.5	1.6	-2.4	-1.1	-0.0	-2.5	-1.8
Ever had bowel cancer screening	2.2	2.6	6.0	2.2	0.8	0.6	2.5	-0.3	1.9	2.0	-0.3	1.3	1.8	-0.8	-2.4
Diabetes diagnosed by doctor	0.4	0.7	2.2	-0.1	-0.3	-1.1	0.4	-1.5	0.7	0.4	-1.1	-0.7	0.2	-1.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	3.1	1.0	1.8	1.3	0.7	0.7	0.2	0.1	0.8	1.4	1.6	0.6	-0.7
Friendships satisfaction	2.4	3.0	5.7	-1.1	0.4	1.6	-1.7	1.9	-2.1	-2.4	2.2	1.4	-0.1	2.2	2.1
Qualifications: nursing, teaching	1.4	2.2	5.9	1.2	2.4	1.5	0.2	1.8	0.2	-0.6	1.9	1.7	1.7	1.6	-0.6
Commuting to job workplace: Walk	1.7	1.8	3.7	-1.5	-1.2	-1.8	-0.8	-1.8	-0.4	-0.7	-1.8	-1.9	-0.3	-1.4	1.4
Eye problems/disorders: Cataract	0.6	0.7	1.8	-0.2	-0.3	-1.3	0.9	-1.3	0.5	0.2	-1.3	-0.6	-1.0	-1.2	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.7	4.2	0.9	-1.2	-0.3	1.9	-0.9	1.8	1.3	-0.8	0.1	2.1	-1.2	-1.3
Medication for cholesterol	0.8	1.2	3.2	0.9	-0.2	1.8	-1.2	1.4	-0.3	-0.3	1.4	1.4	0.9	1.3	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	4.8	0.4	-2.2	-0.5	1.2	-0.7	0.7	1.4	-1.1	-0.5	0.2	-0.9	-0.8
Back pain experienced in last month	2.3	3.3	8.4	1.7	0.0	-0.0	2.8	-1.2	2.9	2.2	-1.2	0.6	2.0	-1.6	-2.5
Mineral and other dietary supplements	3.8	5.1	12.1	-3.2	-0.5	-3.1	-1.8	-1.9	-1.2	-0.9	-2.2	-3.1	-3.5	-1.4	1.7
Breast cancer (self-reported)	0.2	0.3	0.8	-0.3	0.0	0.6	-0.6	0.4	-0.9	-0.4	0.3	-0.1	-0.7	0.5	0.6
Asthma (self-reported)	0.8	1.5	3.4	0.9	1.1	1.6	0.5	1.7	-0.2	-1.2	1.7	1.4	0.5	1.9	-0.4
Osteoporosis (self-reported)	2.0	2.5	5.9	-2.4	-0.5	-1.4	-1.4	-1.0	-1.8	-1.6	-0.9	-1.7	-1.9	-0.5	2.4
Osteoarthritis (self-reported)	1.4	1.9	3.3	0.7	-0.0	-1.4	1.8	-1.6	1.7	1.2	-1.8	-0.7	0.9	-1.6	-1.6
Medication: Aspirin	0.3	0.4	1.2	-0.6	0.2	-1.1	0.5	-0.8	0.0	0.2	-0.7	-0.8	-0.8	-0.7	-0.2
Medication: Gliclazide	0.3	0.4	3.8	-0.1	-2.0	-0.1	0.2	-0.3	0.3	0.1	0.1	-0.3	-0.4	-0.3	0.1
Illnesses of father: None of the above (group 1)	1.9	2.3	6.6	1.0	-0.8	-1.3	2.1	-1.3	2.0	2.6	-1.0	-0.8	0.5	-1.8	-1.5
Smoking status: Current	0.6	0.9	2.5	0.0	-0.9	-0.4	0.3	-1.2	0.6	1.1	-1.6	-0.3	-1.3	-1.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.5	0.7	-0.7	0.5	0.1	0.3	0.3	0.1	0.5	-0.1	0.3	0.1	-0.0
Whole body water mass	0.5	3.0	7.2	-0.3	-1.5	-2.5	0.4	-2.7	1.2	0.3	-2.4	-2.3	-1.3	-2.3	-0.1
Leg predicted mass (right)	0.7	4.0	9.3	-0.4	-1.8	-2.9	-0.1	-3.0	1.4	0.4	-2.7	-2.7	-1.5	-2.7	-0.1
Arm fat mass (left)	0.8	3.2	6.1	1.5	-1.9	-1.4	1.2	-2.3	2.5	1.8	-1.9	-1.1	0.5	-2.5	-1.7
Number of self-reported non-cancer illnesses	1.4	2.4	6.3	-0.8	-1.5	-2.2	1.7	-2.4	0.6	0.1	-2.5	-1.3	-0.7	-2.0	-0.2
Average weekly champagne plus white wine intake	0.6	0.8	4.1	0.4	2.0	0.8	0.8	0.7	-0.2	-0.0	1.3	0.7	1.0	0.6	0.4
Miserableness	0.4	0.7	2.4	-0.8	-0.1	-1.0	0.1	-1.2	0.6	0.3	-0.9	-1.5	-0.2	-1.2	-0.0
Guilty feelings	0.2	0.2	0.9	-0.2	0.9	0.5	0.8	-0.0	0.3	0.1	-0.1	0.5	-0.6	-0.0	-0.4
Wears glasses or contact lenses	0.8	1.0	1.8	0.6	-0.6	-1.0	1.1	-1.1	1.2	1.2	-1.2	-0.4	0.4	-1.3	-0.9
Ever taken oral contraceptive pill	0.9	1.0	3.1	-0.2	-0.2	-1.8	1.0	-1.2	1.1	1.0	-0.9	-0.9	-0.3	-1.3	-0.5
Hearing aid user	0.7	0.8	3.7	-1.0	-1.9	-0.7	-0.6	-0.4	-0.7	-0.2	-0.5	-1.0	-1.0	-0.3	0.9
Mother’s age at death	0.6	0.8	1.7	0.5	-1.1	1.3	-0.4	1.3	-0.6	-0.4	1.1	1.0	0.1	1.3	0.2
Financial situation satisfaction	1.4	1.7	4.5	-1.4	-2.1	-1.6	-0.0	-1.3	-0.3	-0.3	-1.3	-1.9	-1.6	-1.0	1.1
Tinnitus: Yes, now most or all of the time	3.5	4.1	9.3	-2.7	-1.5	-0.2	-3.0	0.8	-2.9	-1.8	0.6	-0.8	-2.8	1.3	2.7
Commuting to job workplace: Public transport	1.1	1.4	2.7	-1.5	0.2	-1.4	-0.5	-1.7	-0.7	-0.9	-1.3	-1.5	-0.6	-1.2	1.5
Eye problems/disorders: Glaucoma	0.3	0.3	1.6	-0.2	-1.2	0.2	0.0	-0.5	-0.1	0.8	-0.8	-0.5	-0.6	-0.5	-0.1
Medication: Blood pressure	0.6	1.1	2.6	-0.4	-0.6	-1.3	1.6	-1.5	0.7	0.3	-1.3	-1.1	0.3	-1.5	-0.1
Pain type(s) experienced in last month: Hip pain	2.1	2.6	6.3	1.0	-1.1	-0.8	2.4	-1.9	2.5	1.6	-1.3	-0.9	0.9	-2.1	-1.7
Supplements: Fish oil (including cod liver oil)	4.9	6.5	15.2	3.9	1.2	2.9	2.6	1.4	2.3	2.2	1.6	3.4	3.4	0.7	-2.9
High cholesterol (Self-reported)	0.5	0.9	3.3	-0.4	-1.8	-0.9	0.6	-1.4	0.3	0.0	-1.5	-0.6	-0.4	-1.2	-0.1
Medication: Bendroflumethiazide	0.2	0.3	1.0	-0.8	-1.0	-0.7	0.2	-0.6	-0.2	-0.8	-0.5	-0.2	-0.4	-0.4	0.5
Medication: Paracetamol	2.3	3.6	10.5	1.1	-1.0	-1.1	3.2	-1.7	2.4	2.4	-1.8	-1.1	1.0	-2.1	-2.2
Medication: Lisinopril	0.8	1.1	2.8	1.7	-1.3	1.1	1.6	0.2	1.1	0.8	-0.1	0.7	0.8	0.1	-1.1
Medication: Atorvastatin	1.4	1.7	5.1	1.5	0.3	-0.5	2.3	-0.6	2.0	1.4	-0.3	-0.1	1.5	-0.9	-1.7
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.1	-0.1	0.7	-0.8	0.4	-0.3	-0.7	0.3	-0.1	0.5	0.5	0.8
Alcohol drinker status: Never	1.5	1.7	4.0	-1.6	-0.6	0.1	-1.8	0.7	-2.0	-1.5	0.4	-0.1	-2.0	1.1	1.6
Ever smoked	0.1	0.2	0.4	-0.1	-0.2	-0.3	-0.1	0.5	-0.4	-0.7	0.5	0.3	0.2	0.7	0.4
Basal metabolic rate	0.6	3.1	7.5	0.2	-1.6	-2.4	0.6	-2.7	1.7	0.7	-2.4	-2.1	-0.9	-2.5	-0.6
Leg fat percentage (left)	0.4	1.5	4.8	2.2	-0.8	0.4	1.1	-0.7	2.1	1.2	-0.3	0.1	1.5	-0.9	-1.6
Arm fat-free mass (left)	0.4	2.0	4.7	0.0	-1.5	-2.0	0.7	-2.2	1.1	0.1	-2.0	-1.7	-0.8	-1.8	-0.2
Number of operations (self-reported)	1.5	2.2	4.8	0.1	-2.0	-2.1	1.4	-2.2	1.3	0.5	-1.9	-1.0	0.2	-2.1	-0.4
Average weekly beer plus cider intake	0.6	0.9	2.7	1.4	-0.3	0.7	0.4	0.5	1.3	1.4	0.6	0.5	0.6	-0.0	-1.6
Irritability	0.4	0.8	1.2	-0.5	0.8	-1.0	0.8	-0.9	0.8	1.0	-1.0	-0.7	0.9	-1.1	-0.6
Risk taking	1.1	1.7	4.3	-0.5	-1.4	-1.4	1.3	-1.5	0.8	1.6	-2.1	-1.0	-0.5	-1.6	-0.6
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.8	-0.0	-1.4	-1.3	0.3	-0.8	0.5	1.0	-0.8	-1.0	-0.3	-0.9	-0.7
Fractured/broken bones in last 5 years	0.6	0.8	2.0	1.1	1.2	0.6	1.2	-0.0	1.0	0.1	0.3	1.3	1.4	-0.1	-1.0
Age started oral contraceptive pill	0.9	1.2	3.7	-1.1	-1.9	-0.9	-0.3	-1.3	-0.6	-0.9	-1.6	-0.7	-1.2	-0.7	0.6
Diastolic blood pressure, automated reading	0.8	2.4	6.5	0.1	-0.9	-1.8	-0.4	-2.5	1.5	1.0	-2.2	-2.0	-0.5	-2.5	-0.2
Ever depressed for a whole week	0.9	1.1	2.9	-0.3	-1.5	-1.1	0.1	-1.7	0.7	0.8	-1.6	-0.8	0.3	-1.7	-0.3
Unable to work because of sickness or disability	1.2	1.6	3.4	1.8	-1.0	0.2	1.8	-0.6	1.7	1.3	-0.7	0.1	1.7	-0.7	-1.7
Commuting to job workplace: Cycle	0.2	0.3	1.1	0.4	0.5	0.7	-0.5	0.6	-0.1	-0.2	0.3	1.1	0.5	0.6	0.0
Myopia	0.5	0.8	2.0	1.4	0.1	0.9	1.2	0.4	1.1	1.0	0.4	0.8	0.7	0.0	-1.1
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.6	1.0	1.0	1.1	-0.6	1.3	0.4	0.7	1.2	1.0	0.9	0.8	-1.1
Cholesterol lowering medication	0.9	1.3	2.5	-0.5	-1.2	-1.3	1.4	-1.5	0.7	1.0	-1.6	-0.8	-0.7	-1.5	-0.4
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	5.1	0.2	-2.2	-0.7	1.1	-1.1	1.1	1.1	-0.7	-1.1	1.0	-1.3	-0.7
Pain experienced in last month	2.0	3.3	7.8	-1.0	1.0	1.4	-2.2	2.3	-2.8	-1.6	1.9	0.8	-1.5	2.5	1.9
Supplements: Calcium	1.0	1.1	3.0	-0.5	-0.1	1.4	-1.7	0.9	-1.7	-1.1	0.8	0.7	-0.6	1.2	0.8
Basal cell carcinoma (self-reported)	1.3	1.5	3.7	-1.5	-0.8	-1.7	-1.0	-1.3	-0.7	-0.9	-1.9	-1.1	-1.5	-0.7	0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.5	0.3	0.5	-0.2	0.7	-0.1	-0.1	-0.2	-0.6	-0.1	-0.2	0.1	0.0
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	5.8	0.2	-0.4	-1.6	1.4	-2.4	1.4	1.2	-2.1	-1.2	0.1	-2.3	-0.8
Heart disease (siblings)	0.3	0.4	1.1	0.6	0.7	-0.4	0.4	-0.7	1.1	-0.0	-0.3	-0.5	0.7	-0.5	-0.8
Alcohol drinker status: Previous	0.5	0.6	1.8	-0.5	-0.8	-1.3	0.5	-1.0	0.4	0.5	-0.9	-0.9	-0.0	-1.0	0.0
Pack years of smoking	1.4	2.1	5.7	-0.5	-1.1	-1.6	0.9	-2.4	0.9	1.2	-2.3	-1.4	-0.3	-2.3	-0.3
Impedance of whole body	0.7	3.7	8.5	0.6	1.9	2.5	-2.4	2.9	-1.1	0.0	2.7	2.0	1.2	2.4	0.3
Leg fat mass (left)	0.5	2.0	5.6	2.1	-1.4	-0.4	1.1	-1.4	2.4	1.4	-1.0	-0.6	0.9	-1.6	-1.6
Arm predicted mass (left)	0.4	2.0	4.8	0.2	-1.3	-1.9	1.0	-2.2	1.2	0.1	-2.0	-1.6	-0.7	-1.9	-0.3