Hub : Genes

SESTD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1130 0.0270 9.2e-09 0.132 0.073 0.102 0.107 0.124 1.0e-15 3.3e-09 1.9e-12 5.8e-13 6.7e-15
2 GTEx Whole Blood 0.1420 0.0450 6.7e-04 0.015 NA 0.020 NA 0.031 1.3e-02 NA 5.8e-03 NA 6.4e-04
3 NTR Blood 0.0549 0.0145 8.7e-08 0.029 0.032 0.034 0.032 0.034 1.1e-09 1.2e-10 3.9e-11 1.5e-10 3.3e-11
4 YFS Blood 0.1612 0.0262 0.0e+00 0.144 0.128 0.150 0.146 0.150 1.2e-44 1.4e-39 1.1e-46 2.1e-45 8.2e-47
5 TCGA Head and Neck Squamous Cell Carcinoma 0.0838 0.0300 7.9e-09 0.067 0.070 0.053 NA 0.065 5.2e-08 2.7e-08 1.4e-06 NA 8.8e-08
6 TCGA Brain Lower Grade Glioma 0.0543 0.0217 1.3e-06 0.022 0.046 0.038 NA 0.036 1.2e-03 6.0e-06 3.1e-05 NA 5.9e-05
7 TCGA Lung Squamous Cell Carcinoma 0.0451 0.0245 4.7e-03 0.017 0.010 0.007 NA 0.014 3.9e-03 2.2e-02 4.6e-02 NA 9.2e-03
8 TCGA Thyroid Carcinoma 0.0930 0.0450 1.3e-03 0.001 0.025 0.023 NA 0.006 2.3e-01 1.7e-03 2.6e-03 NA 8.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.1 0.2 0.5 -0.2 -0.3 -0.3 0.2 0.7 0.3 0.7 0.7
Bipolar Disorder or Schizophrenia 0.2 0.5 1.2 -0.0 -0.8 -0.6 -0.2 1.1 0.3 0.5 1.1
Depressed Affect (Nagel 2018) 0.5 1.1 2.6 1.1 -1.1 -1.6 -1.1 -0.9 -1.2 -0.5 -0.3
Depression (Nagel 2018) 1.4 2.1 4.2 1.3 -1.6 -1.8 -1.4 -2.1 -1.6 0.3 -0.3
Intelligence (Savage-Jansen 2018) 0.8 2.5 4.0 -2.0 1.2 1.8 1.9 1.2 1.4 1.2 -1.8
Neuroticism (Nagel 2018) 0.1 0.3 1.5 0.3 -0.5 -1.2 -0.2 0.3 -0.3 -0.6 -0.2
Schizophrenia (2018) 0.2 0.3 0.8 0.2 -0.8 -0.6 -0.4 0.8 0.1 0.1 0.9
Schizophrenia vs Biploar Disorder 2.4 3.1 5.4 1.8 -1.6 -2.3 -1.9 -1.9 -2.1 -1.4 0.2
Worry (Nagel 2018) 0.1 0.1 0.5 0.0 -0.0 -0.4 0.2 0.7 -0.1 0.2 0.6
Alzheimer’s Disease (in mother) 0.6 0.7 3.8 -0.1 0.1 -0.0 0.3 0.3 0.1 -1.9 -1.4
Alzheimer’s Disease (in father) 0.7 0.7 3.4 -0.6 0.8 0.3 0.6 1.8 0.7 -0.6 0.0
Alzheimer’s Disease (including proxy) 1.0 1.5 3.0 -1.1 0.8 0.7 1.1 1.7 1.2 -1.2 -1.4
Crohns Disease (2017) 0.2 0.5 1.6 0.3 -1.2 -1.2 -0.5 -0.7 -0.3 0.1 -0.6
Irritable Bowel Disease (IBD) 0.5 1.2 2.7 -1.5 0.6 0.2 1.2 0.9 1.5 -0.2 -1.6
Ulcerative Colitis (UC) 2.3 4.3 6.9 -2.6 2.2 1.7 2.5 1.9 2.4 -0.4 -2.1
Major Depression (MDD) 0.8 1.0 2.1 -1.4 1.5 0.6 1.2 0.7 1.0 0.1 -0.5
Reaction Time 4.2 8.0 11.7 3.4 -2.7 -3.1 -3.3 -2.8 -3.1 -2.3 1.0
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.4 -0.9 -0.2 0.6 0.7 0.6 0.6 0.7 -1.2
Breast Cancer 0.0 0.1 0.3 -0.0 -0.6 -0.1 0.2 -0.2 -0.3 0.5 -0.0
Ovarian Cancer 0.8 1.1 2.8 0.8 -1.7 -0.9 -1.1 0.1 0.2 0.5 1.7
Prostate Cancer 0.1 0.2 0.6 0.1 -0.1 -0.1 0.0 -0.7 -0.3 -0.2 -0.8
Age at First Birth 1.6 2.3 4.5 1.5 -1.3 -1.4 -1.4 -1.7 -2.1 -1.2 -1.1
Bipolar Disorder (2011) 1.0 1.0 3.2 0.9 -1.8 -1.6 -1.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.9 1.6 0.8 -1.1 -1.2 -1.1 -1.3 -0.9 -0.3 0.3
Coronary Artery Disease (CAD) 0.0 0.0 0.2 -0.1 -0.0 -0.0 0.0 0.4 0.2 -0.0 -0.4
Crohns Disease (2012) 0.2 0.3 1.6 -0.1 -0.3 -0.6 -0.1 -0.7 -0.0 -0.1 -1.2
Mean Putamen Volume 0.2 0.2 0.8 0.4 0.4 -0.4 -0.4 -0.2 -0.1 -0.9 -0.0
Fasting Glucose 0.2 0.2 0.5 0.4 -0.3 -0.7 -0.5 -0.3 -0.5 -0.3 -0.2
HbA1C 1.6 1.8 3.3 1.6 -1.1 -1.1 -1.8 -1.2 -1.4 0.4 1.6
HDL Cholesterol 0.3 0.5 1.0 -0.5 0.9 0.4 0.6 1.0 0.9 0.4 0.6
LDL Cholesterol 0.3 0.5 1.3 0.5 -1.1 -0.6 -0.9 -0.1 -0.5 0.3 -0.9
Lupus 1.0 1.6 3.1 0.9 -1.3 -1.3 -0.8 -1.8 -1.1 -1.1 -1.5
Neuroticism (2016) 0.3 0.5 1.1 -0.4 0.2 0.5 0.5 1.0 0.8 1.0 0.5
Primary Biliary Cirrhosis 0.1 0.1 0.5 0.1 -0.7 -0.1 -0.0 0.1 -0.4 -0.4 -0.2
Rheumatoid Arthritis 0.5 0.6 1.5 -0.3 0.1 0.0 0.2 1.1 1.0 1.2 1.1
Schizophrenia (2014) 0.3 0.6 1.4 0.8 -1.0 -1.0 -0.8 0.4 -0.5 0.1 1.2
Triglycerides 0.5 0.9 1.8 1.0 -1.4 -0.6 -1.1 -1.0 -1.2 -0.5 0.4
Type 2 Diabetes (T2D) (2012) 1.2 1.3 5.9 0.1 0.1 0.0 -0.3 1.3 0.1 1.7 2.4
Ulcerative Colitis 3.0 4.4 6.9 -2.3 2.0 2.0 2.4 2.6 2.5 -0.7 -1.4
Blood Eosinophil Count 0.1 0.6 2.7 -0.6 0.2 0.6 0.6 0.8 0.5 1.6 -0.2
Blood Platelet Count 0.3 2.9 4.9 1.8 -2.0 -2.2 -2.0 -2.0 -1.5 0.3 0.9
Blood Red Count 0.0 0.4 1.0 -0.1 0.5 0.9 0.3 0.0 0.5 -0.8 1.0
Blood White Count 0.1 1.1 3.9 0.2 -1.2 0.0 -0.2 0.1 0.3 2.0 1.7
Heel T-Score 0.4 2.8 4.3 1.5 -2.0 -2.1 -2.0 -1.7 -1.9 0.4 -0.8
BMI 0.3 1.9 5.1 1.4 -1.1 -1.2 -1.7 -0.8 -1.2 0.8 2.2
Height 0.1 2.7 4.4 -1.9 1.8 1.8 2.1 0.7 1.2 1.2 -2.1
Waist Hip Ratio (WHR) 0.8 3.5 7.5 2.2 -1.4 -1.3 -2.4 -2.7 -2.1 0.2 1.3
Systolic Blood Pressure 0.3 1.5 5.8 1.3 -0.4 -0.8 -1.4 -0.2 -0.5 1.3 2.4
Smoking Status 0.1 0.2 1.0 0.0 -0.1 -0.0 -0.2 -0.2 0.0 1.0 0.4
Allergy or Eczema 0.0 0.1 0.2 -0.1 -0.4 0.1 0.3 0.5 0.2 0.3 0.3
Cardiovascular Disease 0.6 2.0 4.8 1.4 -1.5 -1.6 -1.5 -0.4 -0.9 1.0 2.2
Hypothyroidism (self reported) 0.1 0.2 0.4 -0.1 0.2 -0.2 -0.1 -0.7 -0.3 0.6 -0.5
Respiratory disease 0.1 0.1 0.6 -0.4 -0.1 0.0 0.3 -0.4 0.3 0.1 -0.8
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.9 -0.2 0.1 0.2 0.3 1.0 0.9 -0.3 0.8
Lung FEV1/FVC ratio 0.5 2.5 5.6 -1.5 1.6 2.4 1.6 1.8 1.6 1.0 0.5
Lung FVC 0.4 2.0 7.5 0.5 -1.4 -1.2 -0.7 0.0 0.1 -2.7 -2.0
Neuroticism 0.3 0.8 2.3 0.9 -0.9 -1.5 -1.0 -0.4 -1.0 -0.3 0.6
Chronotype (morning person) 0.3 0.7 4.2 -0.2 -0.9 -0.0 0.1 -0.3 0.3 2.1 0.7
Hair Pigment 0.1 2.4 6.8 -1.9 0.7 1.4 1.9 0.7 1.2 2.6 -1.0
Tanning 0.0 0.2 0.4 0.6 -0.4 -0.3 -0.6 -0.6 -0.4 -0.2 0.4
Hand grip strength (left) 1.2 3.2 7.2 2.0 -2.1 -2.7 -2.3 -0.8 -1.1 -1.2 1.2
Number of treatments/medications taken 0.1 0.3 0.7 -0.8 -0.2 0.0 0.5 -0.2 0.5 0.6 -0.7
Average weekly spirits intake 2.4 2.9 3.9 -2.0 1.9 1.9 2.0 1.2 1.7 1.6 -1.1
Sensitivity / hurt feelings 0.4 0.7 2.7 -0.2 -0.3 -0.7 0.4 0.1 0.4 -1.6 -1.4
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.6 -0.4 0.8 0.3 0.5 -0.3 0.4 0.2 -0.8
Hearing difficulty/problems: Yes 0.6 0.9 3.2 -0.6 0.0 0.3 0.7 -1.6 0.0 -0.9 -1.8
Relative age of first facial hair 0.8 1.6 3.3 -1.5 1.4 1.5 1.8 0.9 0.9 0.0 -1.1
Other serious medical condition/disability diagnosed by doctor 3.4 4.4 9.1 1.8 -2.5 -2.2 -2.1 -3.0 -2.3 -0.8 -0.9
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.1 0.2 0.5 -0.1 0.0 -0.4 -0.3 -1.1 -0.9
Ever had hysterectomy (womb removed) 0.4 0.4 1.9 -0.0 -0.1 -0.3 -0.1 0.2 0.2 1.4 1.2
Systolic blood pressure, automated reading 0.2 0.7 1.7 0.8 -0.5 -0.5 -0.8 0.3 -0.4 1.3 1.3
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 3.0 1.0 -1.7 -1.6 -1.0 -1.5 -1.2 -0.5 0.0
Angina 0.5 0.6 1.7 0.5 -0.9 -1.3 -0.9 -0.7 -0.6 0.5 -0.3
Medication for hormone replacement therapy 1.2 1.4 2.2 -1.0 1.5 1.3 1.4 0.6 1.0 1.4 -0.7
Vitamin and mineral supplements 1.7 2.3 6.0 -1.3 1.4 1.5 1.4 2.5 2.0 0.2 0.2
Supplements: Zinc 0.3 0.4 2.0 0.1 -0.2 -0.0 -0.1 -0.9 -0.3 -0.0 -1.4
Medication: Co-codamol 0.1 0.1 0.3 -0.2 0.2 0.2 0.2 0.2 0.3 -0.1 -0.6
Medication: Metformin 0.4 0.5 1.1 1.0 -0.6 -0.8 -0.7 -0.2 -0.7 -0.9 0.2
Diabetes (father) 1.1 1.3 3.9 0.8 -0.8 -1.2 -0.9 -2.0 -1.2 -0.5 -1.2
Diabetes (mother) 0.6 0.8 2.5 -0.8 1.6 0.6 0.7 -0.2 0.8 -0.9 -1.0
Severe depression (siblings) 1.3 1.5 2.6 -1.5 1.0 1.1 1.6 1.4 1.4 -0.4 -0.7
Pack years adult smoking proportion 1.3 2.0 3.5 1.4 -1.8 -1.9 -1.6 -1.4 -1.4 0.6 0.8
Impedance of leg (right) 0.4 2.0 3.9 -1.6 2.0 1.6 1.6 1.3 1.6 0.7 -0.4
Leg fat-free mass (left) 0.3 1.7 2.3 1.5 -1.3 -1.1 -1.5 -1.4 -1.4 0.3 1.5
Trunk fat percentage 0.5 1.9 9.2 1.3 0.1 -0.7 -1.6 -0.5 -0.8 0.6 3.0
Hand grip strength (right) 1.9 5.1 11.0 2.4 -2.5 -3.3 -3.0 -1.4 -1.5 -0.6 2.0
Townsend deprivation index at recruitment 0.1 0.2 0.6 -0.1 -0.0 0.1 0.1 -0.8 -0.0 -0.5 -0.6
Current tobacco smoking 0.2 0.3 0.7 0.6 -0.7 -0.2 -0.5 -0.8 -0.5 0.4 0.4
Average weekly fortified wine intake 1.1 1.3 3.0 0.9 -1.7 -1.4 -1.1 -0.5 -0.4 -1.6 -0.6
Maternal smoking around birth 1.3 1.9 4.8 1.5 -1.4 -2.2 -1.6 -1.1 -1.2 -0.9 0.7
Fed-up feelings 0.6 1.2 2.4 0.7 -1.3 -1.5 -0.8 -1.4 -1.0 -0.3 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.2 0.8 -1.1 -0.6 -0.7 -0.6 -0.6 0.3 0.9
Relative age voice broke 0.2 0.4 1.3 -0.5 0.7 0.5 0.7 -0.1 0.0 -0.4 -1.1
Taking other prescription medications 0.7 1.1 4.9 -1.0 0.4 0.7 1.0 -1.2 -0.2 -0.1 -2.2
Age when periods started (menarche) 0.5 1.1 2.8 -1.2 0.0 0.4 1.1 1.0 1.3 0.7 -1.7
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.9 0.5 0.2 -0.6 -0.4 -1.4 -1.0 -0.4 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 4.7 -0.5 0.9 0.5 0.7 0.7 0.5 -2.2 -1.2
Tinnitus: Yes, but not now, but have in the past 6.1 6.5 10.0 3.1 -2.5 -2.5 -3.2 -2.3 -3.0 -1.2 2.1
Qualifications: CSEs or equivalent 0.3 0.4 1.3 -0.4 0.6 0.5 0.5 0.8 0.5 -1.1 -0.1
Serious illness, injury or assault to yourself 0.4 0.4 1.2 0.1 -1.1 -0.7 -0.4 -1.1 -0.7 -0.0 -0.3
High blood pressure 0.2 0.6 1.0 0.6 -0.6 -0.8 -0.8 -1.0 -0.7 0.9 0.7
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.6 -0.1 -0.2 0.4 0.3 0.4 0.2 0.0 0.8
Multivitamins +/- minerals 2.1 2.6 5.7 1.7 -1.2 -1.7 -1.8 -2.4 -2.1 -0.7 0.5
Stomach or abdominal pain in last month 0.8 1.0 4.2 -0.0 -1.0 -1.0 -0.3 -2.0 -1.0 -0.3 -1.0
Supplements: Glucosamine 0.4 0.5 1.8 0.4 0.1 -0.1 -0.3 -1.3 -0.8 -0.8 -0.9
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.9 0.3 -0.9 -1.0 -0.7 0.5 0.6 0.3 0.9
Medication: Atenolol 1.5 1.9 3.2 -1.8 1.1 1.7 1.7 1.0 1.4 0.9 -1.2
Medication: Levothyroxine sodium 0.3 0.5 1.1 0.3 0.5 -0.5 -0.4 -1.0 -0.7 -1.0 -1.0
Sitting height 0.2 1.5 4.3 -1.2 1.5 1.2 1.3 -0.8 -0.1 0.4 -2.1
Chronic bronchitis/emphysema (father) 1.2 1.4 6.1 -0.5 0.7 -0.4 0.6 -0.3 0.1 -2.5 -2.0
High blood pressure (mother) 0.1 0.2 0.6 -0.2 -0.5 -0.6 0.1 0.3 0.1 -0.0 -0.8
Body mass index (BMI) 0.8 3.2 9.1 1.8 -1.7 -1.7 -2.2 -1.0 -1.2 0.3 3.0
Impedance of leg (left) 0.6 2.9 5.9 -1.9 2.4 1.6 1.8 1.8 2.0 0.0 -0.6
Leg predicted mass (left) 0.3 1.6 2.1 1.4 -1.3 -1.1 -1.4 -1.4 -1.4 0.3 1.4
Trunk fat mass 0.4 1.8 7.1 1.4 -0.3 -1.0 -1.6 -0.8 -1.0 0.4 2.7
Waist circumference 1.3 4.7 8.8 2.5 -2.0 -2.1 -2.8 -1.7 -1.9 -0.0 3.0
Number of incorrect matches in round 0.4 0.6 2.5 -0.0 -0.7 -0.1 -0.0 -0.1 0.5 1.6 1.4
Past tobacco smoking 0.1 0.3 0.9 0.7 -0.6 -0.2 -0.4 0.1 -0.3 -0.1 0.9
Alcohol usually taken with meals 0.2 0.3 1.0 0.2 0.4 0.3 -0.1 1.0 0.3 -0.4 0.9
Nervous feelings 1.0 1.9 4.3 -1.3 1.4 1.1 1.5 2.1 1.6 0.8 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 2.7 -0.4 0.4 0.5 0.4 -0.5 0.1 1.6 0.3
Hearing difficulty/problems with background noise 0.9 1.5 7.0 -1.0 0.8 0.5 1.1 -0.7 0.6 -1.1 -2.6
Hair/balding pattern: Pattern 2 0.1 0.2 0.6 -0.3 -0.6 -0.8 0.0 0.5 0.1 -0.2 0.0
Had menopause 0.3 0.3 1.1 0.5 -0.6 -1.1 -0.6 -0.1 -0.3 -0.4 -0.6
Had other major operations 0.7 0.9 2.0 1.0 -0.7 -0.7 -1.1 -1.2 -1.4 -0.1 0.6
Forced vital capacity (FVC) 0.5 1.8 7.1 -1.4 0.5 0.8 1.5 0.6 1.1 -0.9 -2.7
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 1.3 0.4 -0.4 -0.5 -0.5 0.1 -0.5 -1.1 0.2
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 3.0 0.4 -0.7 -1.1 -0.4 -1.2 -0.8 -1.7 -1.7
Qualifications: None of the above 2.0 4.3 7.4 2.1 -1.7 -2.7 -2.7 -2.6 -2.3 -0.3 0.5
Financial difficulties in last 2 years 2.1 2.8 4.7 -2.1 1.5 1.8 1.9 1.8 2.2 1.0 -0.1
Mouth/teeth dental problems 1.3 2.0 3.8 -1.9 1.3 1.6 1.9 0.1 0.8 0.2 -1.9
Heart attack 1.6 2.0 4.1 1.3 -1.3 -1.3 -1.5 -2.0 -1.7 1.0 0.5
Allergy 0.1 0.2 0.4 0.6 0.0 -0.5 -0.6 -0.3 -0.4 -0.3 0.7
Pain all over the body in last month 0.2 0.2 0.7 0.1 -0.5 -0.3 -0.2 -0.9 -0.4 -0.3 0.2
Diabetes (self-reported) 0.2 0.3 1.5 0.3 -0.2 -0.4 -0.0 -0.3 -0.3 -1.2 -0.6
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 3.9 -0.9 0.6 1.6 1.0 1.6 1.1 2.0 1.0
Medication: Ramipril 1.9 2.4 4.7 1.9 -1.8 -2.2 -2.0 -1.5 -1.2 -0.2 0.3
Medication: Simvastatin 2.2 3.2 5.8 1.8 -2.4 -2.3 -1.9 -1.8 -1.8 -0.6 0.7
Fluid intelligence score 0.8 1.7 3.6 -1.6 1.0 0.9 1.4 1.3 1.0 1.0 -1.9
Illnesses of siblings 0.3 0.5 1.0 0.7 -1.0 -0.6 -0.7 -0.5 -0.8 0.1 -0.7
Neuroticism score 0.1 0.2 0.4 -0.5 0.2 -0.1 0.6 0.6 0.5 0.5 -0.1
Weight 0.5 2.2 4.3 1.6 -1.2 -1.4 -1.8 -1.4 -1.4 0.0 2.1
Impedance of arm (right) 1.0 4.5 10.0 -1.9 3.2 2.6 2.3 1.9 2.0 1.6 -0.0
Arm fat percentage (right) 0.5 2.0 9.2 1.4 -0.4 -0.9 -1.6 -0.7 -0.9 0.7 3.0
Trunk fat-free mass 0.2 1.1 2.1 1.0 -1.4 -1.2 -1.1 -1.4 -1.1 -0.4 0.0
Hip circumference 0.5 2.0 6.5 1.5 -1.1 -1.2 -1.6 -0.6 -1.0 0.4 2.5
Time employed in main current job 0.5 0.6 3.5 -0.3 0.3 -0.3 0.3 -0.5 -0.2 -0.9 -1.9
Alcohol intake versus 10 years previously 0.1 0.1 0.2 0.3 -0.2 0.2 -0.2 0.3 0.2 -0.3 0.5
Father’s age at death 3.1 4.1 6.0 2.1 -1.5 -2.4 -2.1 -2.1 -2.4 -2.4 -0.5
Worrier / anxious feelings 0.1 0.3 1.4 -0.1 0.6 0.1 0.3 0.5 0.1 -1.2 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 2.0 1.1 -1.2 -1.1 -1.4 -0.9 -1.1 1.1 1.2
Falls in the last year 1.1 1.5 3.0 -1.5 1.7 1.4 1.4 0.4 1.2 0.8 -0.8
Hair/balding pattern: Pattern 3 0.4 0.5 1.4 0.6 -0.6 -0.8 -0.6 -1.2 -0.7 -0.2 -0.8
Number of live births 1.4 1.9 5.1 -1.1 0.7 1.3 1.0 2.3 2.0 0.3 1.3
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 3.1 -1.7 0.8 1.5 1.8 1.6 1.6 0.1 -1.5
Pulse rate 0.8 1.3 5.0 -0.5 -0.4 -0.8 0.2 -1.5 -0.0 -1.4 -2.2
Happiness 1.0 1.3 2.8 1.1 -1.7 -1.3 -1.0 0.4 -0.5 -1.4 1.1
Noisy workplace 2.3 2.8 5.2 1.8 -1.2 -1.4 -1.7 -2.3 -2.1 -1.6 0.5
Qualifications: A levels/AS levels or equivalent 0.5 1.1 1.9 -1.1 0.0 1.1 1.0 1.3 1.3 1.4 0.1
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.8 3.7 -1.4 1.9 1.3 1.5 1.3 1.0 0.2 -1.2
Mouth/teeth dental problems: Dentures 1.9 3.3 4.9 2.2 -2.1 -1.6 -2.0 -2.2 -2.0 -0.7 0.8
Asthma 0.7 1.4 5.0 -1.1 0.9 0.7 1.1 0.3 1.2 -0.8 -2.2
Medication: Ibuprofen (e.g. Nurofen) 0.7 1.0 2.2 1.1 -1.5 -1.0 -1.2 -0.1 -1.1 -0.2 0.9
Medication: Cholesterol lowering 0.1 0.2 0.3 0.2 -0.5 -0.6 -0.4 -0.5 -0.5 0.3 0.5
Depression (self-reported) 0.4 0.5 0.9 -0.4 0.9 0.9 0.5 0.9 0.6 -0.8 0.5
Medication: Lansoprazole 1.8 2.0 3.4 1.7 -1.6 -1.6 -1.7 -0.6 -1.2 -0.0 1.9
Prospective memory result 0.7 0.9 2.0 0.5 -1.1 -1.0 -0.6 -1.4 -0.7 1.4 -0.0
Lung cancer (father) 0.2 0.3 0.7 0.2 -0.8 -0.7 -0.4 -0.4 -0.5 -0.6 -0.4
Illnesses of mother 0.3 0.4 1.1 0.5 -0.5 -0.2 -0.5 -1.0 -0.7 0.7 0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 5.2 -1.8 1.6 1.8 1.8 2.3 2.2 0.3 -0.6
Pulse wave Arterial Stiffness index 0.6 0.7 3.1 0.8 0.3 -0.8 -1.0 0.0 -0.4 -1.8 -0.5
Impedance of arm (left) 1.2 5.7 12.7 -2.1 3.6 2.8 2.4 2.4 2.2 1.9 0.7
Arm fat mass (right) 0.5 2.2 8.1 1.5 -0.7 -1.2 -1.8 -1.0 -1.1 0.5 2.8
Trunk predicted mass 0.2 1.0 2.0 0.9 -1.4 -1.2 -1.0 -1.4 -1.1 -0.4 0.0
Standing height 0.1 0.7 3.2 -0.4 0.9 0.4 0.6 -0.9 -0.5 -0.1 -1.8
Length of working week for main job 0.8 0.9 4.0 0.5 -0.5 -0.5 -0.7 -0.8 -0.8 2.0 0.9
Exposure to tobacco smoke at home 1.1 1.2 2.7 1.2 -0.9 -1.6 -1.3 -1.1 -0.8 -1.3 -0.2
Breastfed as a baby 0.6 0.8 4.3 -0.7 -0.4 -0.3 0.3 -0.4 0.4 -0.9 -2.1
Tense / ‘highly strung’ 0.3 0.4 0.7 0.8 -0.4 -0.6 -0.6 0.1 -0.8 0.7 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.9 5.6 -2.1 1.7 1.7 2.0 1.8 2.4 0.3 -0.2
Hair/balding pattern: Pattern 4 1.1 2.7 5.9 -1.5 2.2 2.4 1.6 0.9 1.6 1.7 0.3
Birth weight of first child 0.5 0.9 3.5 0.1 0.5 -0.4 -0.3 -0.9 -0.6 -1.9 -1.5
Peak expiratory flow (PEF) 4.2 9.6 14.1 -3.7 2.6 3.5 3.7 3.8 3.7 1.3 -1.1
Pulse wave reflection index 0.3 0.3 0.7 0.6 0.4 0.1 -0.6 -0.1 -0.7 -0.8 -0.7
Ever highly irritable/argumentative for 2 days 1.4 1.7 3.0 1.4 -1.0 -1.7 -1.5 -1.1 -1.1 -1.7 -0.1
Loud music exposure frequency 0.6 0.7 3.0 -0.2 0.8 -0.1 0.4 -0.6 -0.0 -1.7 -1.2
Qualifications: O levels/GCSEs or equivalent 2.0 3.2 6.8 -2.3 1.3 1.7 2.1 2.0 2.6 0.4 -0.8
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 3.2 -0.9 0.7 0.5 0.7 1.8 1.8 0.7 0.6
Blood clot in the leg (DVT) 0.4 0.6 2.0 0.1 -0.8 -0.2 -0.3 -1.4 -0.4 1.2 -0.4
Medication: Paracetamol 0.2 0.4 1.6 -0.1 -0.6 -0.3 -0.1 0.2 -0.2 1.3 1.0
Headache pain in last month 0.5 0.8 1.8 -1.2 -0.6 0.4 1.0 0.8 0.5 0.9 -1.3
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.5 0.0 0.7 0.5 0.1 0.2 0.3 -0.2 0.0
Glaucoma (self-reported) 0.9 1.1 2.9 -0.9 1.7 1.3 1.0 0.5 0.6 0.3 1.1
Gout (self-reported) 0.1 0.2 0.7 0.1 -0.3 -0.2 -0.4 -0.2 -0.3 -0.6 0.9
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.0 0.4 0.1 -0.7 -0.5 -1.4 -1.0 -0.3 -0.6
Medication: Amlodipine 0.6 0.9 1.7 1.3 -0.6 -1.1 -1.1 -0.7 -1.1 -0.5 0.6
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.3 -0.5 0.4 0.5 0.5 -0.5 0.5 0.4 -0.2
Birth weight 0.3 0.7 1.7 0.9 -1.3 -1.3 -1.0 -0.4 -0.5 -0.3 0.6
Chronic bronchitis/emphysema (mother) 0.5 0.5 1.2 -0.6 1.1 0.1 0.2 0.5 0.6 1.1 0.9
High blood pressure (siblings) 0.2 0.2 1.1 0.2 0.3 -0.2 -0.3 0.1 -0.6 -1.0 0.6
Forced vital capacity (FVC), Best measure 0.5 1.7 2.7 -1.5 1.1 1.1 1.5 1.2 1.6 -0.3 -1.6
Body fat percentage 0.6 2.3 11.1 1.5 -0.2 -1.0 -1.8 -0.6 -0.8 0.4 3.3
Leg fat percentage (right) 0.8 2.8 10.3 1.6 -1.3 -1.4 -2.0 -1.0 -1.0 0.3 3.2
Arm fat-free mass (right) 0.4 2.1 3.0 1.5 -1.7 -1.7 -1.7 -1.6 -1.5 -0.8 0.7
Exposure to tobacco smoke outside home 0.2 0.2 0.6 -0.2 0.4 0.1 0.2 0.7 0.5 -0.8 0.5
Comparative body size at age 10 0.2 0.7 2.3 -0.3 -0.4 -0.0 -0.1 1.0 1.1 0.6 1.5
Number of full brothers 2.3 2.8 5.7 -2.4 1.8 1.6 1.9 1.6 2.1 0.7 -0.5
Worry too long after embarrassment 0.2 0.3 1.4 -0.0 -0.1 -0.6 0.0 1.2 0.6 -0.3 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 0.9 -0.6 0.8 0.8 0.6 0.9 1.0 0.5 0.7
Wheeze or whistling in the chest in last year 0.0 0.1 0.2 -0.4 0.3 -0.0 0.1 0.3 0.5 -0.2 0.1
Number of children fathered 0.6 0.7 1.8 0.4 0.2 -0.9 -0.5 -0.9 -0.4 -1.2 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.4 -0.1 0.6 0.0 0.2 -0.0 -0.1 -0.1 -0.5
Age at first live birth 0.3 0.6 1.8 0.7 -1.0 -0.5 -0.8 -0.8 -1.3 0.3 0.1
Pulse wave peak to peak time 0.5 0.6 2.4 -0.8 -0.2 0.7 1.0 0.0 0.4 1.6 0.4
Health satisfaction 0.9 1.2 3.7 1.2 -0.8 -1.1 -1.1 0.1 -0.9 -0.6 1.9
Shortness of breath walking on level ground 1.1 1.3 6.2 1.0 -0.4 -0.9 -1.3 -0.2 -0.6 0.5 2.5
Qualifications: College or University degree 1.9 6.1 11.7 -2.5 2.5 3.4 2.8 2.7 2.7 1.6 -0.4
Eye problems/disorders: None of the above 0.3 0.4 0.6 -0.5 0.8 0.7 0.6 0.6 0.7 0.3 -0.4
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.1 0.6 -0.3 -0.5 -0.6 -0.8 -1.0 -0.4 -0.1
Emphysema/chronic bronchitis 1.0 1.1 3.2 -1.0 0.9 0.4 1.1 0.4 0.9 -1.2 -1.8
Medication for pain relief, constipation, heartburn 0.6 1.1 2.9 -0.7 1.7 1.5 1.0 0.2 0.9 -0.7 -0.8
Neck or shoulder pain in last month 1.6 2.3 3.9 -1.8 1.6 1.3 1.6 2.0 1.5 1.5 0.7
Medication: Blood pressure 1.3 2.3 4.4 1.5 -1.8 -2.1 -1.7 -1.7 -1.6 -0.1 0.2
Angina (self-reported) 0.2 0.3 1.0 0.2 -0.7 -1.0 -0.5 -0.3 -0.2 0.7 -0.3
Migraine (self-reported) 0.4 0.5 2.3 -0.3 -0.5 0.3 0.2 1.5 0.8 -0.2 0.9
Medication: Ibuprofen 1.2 1.4 2.3 1.4 -1.5 -1.2 -1.5 0.0 -1.1 -0.1 1.5
Medication: Allopurinol 0.1 0.2 1.0 -0.5 0.1 0.1 0.2 -0.1 -0.2 -1.0 -0.2
Medication: Omeprazole 0.2 0.3 0.8 -0.5 -0.3 0.4 0.5 -0.0 0.7 0.4 -0.9
Medication: Seretide 50 evohaler 0.2 0.2 0.7 -0.3 -0.6 -0.1 0.1 -0.9 0.5 -0.0 -0.2
Mean time to correctly identify matches 6.7 12.8 18.9 4.3 -3.6 -4.0 -4.2 -3.3 -4.0 -3.0 0.9
Heart disease (mother) 0.7 0.8 1.6 -0.9 0.8 0.7 0.9 1.3 1.2 0.5 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 -0.1 -0.4 -0.4 0.1 0.1 0.1 0.4 0.0
Whole body fat mass 0.6 2.6 8.8 1.7 -0.8 -1.4 -2.0 -1.1 -1.2 0.3 3.0
Leg fat mass (right) 0.8 2.9 8.6 1.8 -1.2 -1.6 -2.1 -1.2 -1.3 0.1 2.9
Arm predicted mass (right) 0.4 1.8 2.9 1.3 -1.7 -1.6 -1.6 -1.5 -1.4 -0.8 0.5
Pulse rate, automated reading 0.7 2.3 5.2 0.4 -1.7 -2.3 -1.0 -1.8 -0.6 -1.2 -1.9
Alcohol intake frequency. 1.3 3.0 5.6 2.2 -1.3 -1.7 -2.0 -2.4 -2.2 0.1 0.1
Comparative height size at age 10 0.1 0.4 1.5 -0.3 0.5 0.5 0.4 -0.6 0.3 1.2 -0.5
Number of full sisters 1.2 1.5 4.1 -0.7 2.0 0.8 0.8 -0.4 0.1 -1.8 -1.6
Suffer from ‘nerves’ 0.8 1.2 6.0 -0.6 -0.3 0.2 0.5 1.1 0.4 2.5 1.4
Overall health rating 1.1 2.4 6.8 2.0 -1.1 -1.2 -1.9 -0.6 -1.4 -0.1 2.6
Chest pain or discomfort 0.1 0.1 0.5 -0.2 -0.2 -0.7 -0.0 0.2 0.6 0.3 0.2
Had major operations 0.2 0.2 0.8 0.4 -0.8 -0.2 -0.4 -0.0 -0.0 0.4 0.9
Age at last live birth 0.2 0.3 1.0 0.5 -1.0 -0.6 -0.6 -0.1 -0.5 -0.2 -0.5
Family relationship satisfaction 0.2 0.2 0.8 0.4 -0.0 -0.4 -0.5 0.4 0.0 -0.9 0.5
Leg pain on walking 0.1 0.2 0.7 0.4 -0.1 0.2 -0.2 0.4 0.2 -0.1 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.7 0.4 -0.5 -0.0 -0.2 0.4 -0.3 0.9 1.3
Commuting to job workplace: Car/motor vehicle 1.0 1.2 2.2 1.5 -1.2 -0.7 -1.2 -0.9 -1.1 0.0 1.4
Illness, injury, bereavement, stress in last 2 years 1.0 1.3 2.8 1.7 -0.6 -0.9 -1.4 -0.5 -0.9 -0.9 1.5
Medication: Aspirin 0.7 0.9 1.5 0.8 -1.0 -1.2 -1.2 -0.9 -1.0 0.8 0.7
Supplements: Vitamin C 0.6 0.8 4.7 -0.5 -0.5 0.6 0.4 -0.3 0.3 2.2 0.5
Knee pain experienced in last month 0.4 0.7 2.1 -0.5 1.0 0.3 0.6 1.0 0.5 -1.5 0.6
Hypertension (Self-reported) 0.6 1.5 2.0 1.2 -1.3 -1.3 -1.4 -1.0 -1.2 1.1 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 2.2 -0.4 0.9 0.6 0.6 0.9 0.6 -1.5 0.3
Illnesses of father: Heart disease 0.2 0.2 0.7 -0.9 0.1 0.2 0.5 -0.1 0.2 0.2 -0.9
Illnesses of siblings: Diabetes 0.5 0.6 1.1 -0.8 0.6 0.6 0.7 0.7 1.0 1.1 0.2
Smoking status: Previous 0.1 0.2 0.6 -0.5 0.1 -0.4 0.1 -0.4 0.0 0.2 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.8 3.7 -1.9 1.3 1.1 1.7 0.7 1.2 1.3 -0.9
Whole body fat-free mass 0.3 1.5 2.2 1.3 -1.5 -1.4 -1.4 -1.4 -1.4 -0.2 0.7
Leg fat-free mass (right) 0.2 1.2 1.6 1.2 -1.0 -1.0 -1.3 -1.1 -1.2 -0.1 1.2
Arm fat percentage (left) 0.5 2.1 11.2 1.3 -0.1 -0.7 -1.5 -0.4 -0.7 0.6 3.4
Average weekly red wine intake 1.4 2.0 3.1 -1.5 1.7 1.8 1.6 1.7 1.3 -0.2 -0.8
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.9 -0.1 0.0 0.5 0.3 -0.4 -0.1 -0.3 -1.0
Mood swings 0.1 0.2 0.5 -0.4 0.5 -0.1 0.4 0.7 0.5 -0.2 -0.2
Loneliness, isolation 2.6 3.6 5.5 -2.0 2.4 1.8 2.0 1.8 2.4 1.8 0.1
Long-standing illness, disability or infirmity 0.8 1.3 3.1 0.1 -1.2 -0.7 -0.3 -1.7 -1.1 1.1 -1.8
Ever had bowel cancer screening 0.8 1.0 3.2 1.1 -0.7 -0.9 -1.1 0.2 -0.7 -1.8 0.7
Diabetes diagnosed by doctor 0.1 0.2 0.9 -0.2 0.1 -0.1 0.4 0.2 0.4 -1.0 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 -0.3 0.6 0.5 0.4 0.4 0.7 -0.0 0.7
Friendships satisfaction 0.4 0.5 2.2 0.6 -0.5 -0.2 -0.5 1.1 0.2 -0.1 1.5
Qualifications: nursing, teaching 0.5 0.8 1.5 -1.1 1.0 1.2 1.1 0.4 0.7 0.7 -0.8
Commuting to job workplace: Walk 0.6 0.6 1.5 -0.8 1.2 0.4 0.6 1.0 0.9 0.6 -0.1
Eye problems/disorders: Cataract 0.3 0.3 1.5 0.1 -0.3 -0.8 -0.4 0.5 0.1 -1.2 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.5 0.9 1.5 1.2 -0.6 -1.2 -1.2 -0.3 -0.9 -0.1 1.0
Medication for cholesterol 0.3 0.5 1.1 -0.4 1.0 1.0 0.4 1.0 0.1 -0.5 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.8 1.9 -0.1 1.2 1.2 0.4 1.4 0.6 0.1 0.7
Back pain experienced in last month 0.6 0.9 2.4 -1.1 1.1 0.7 1.1 0.1 0.6 -0.3 -1.5
Mineral and other dietary supplements 2.3 3.0 7.1 -1.4 2.0 1.9 1.6 2.7 1.9 0.5 1.0
Breast cancer (self-reported) 0.5 0.6 1.7 -0.5 0.5 1.3 0.8 0.7 0.8 0.6 0.6
Asthma (self-reported) 0.6 1.2 3.4 -1.1 0.9 0.8 1.1 0.4 1.3 -0.6 -1.8
Osteoporosis (self-reported) 0.1 0.1 0.3 0.3 -0.6 -0.3 -0.1 0.2 -0.1 -0.0 -0.5
Osteoarthritis (self-reported) 1.3 1.6 2.4 1.4 -1.4 -1.4 -1.6 -1.3 -1.4 -1.1 0.3
Medication: Aspirin 0.8 1.0 1.8 0.6 -1.1 -1.2 -1.0 -1.3 -0.9 1.2 0.3
Medication: Gliclazide 1.6 1.8 3.2 -1.8 1.3 1.1 1.6 1.2 1.5 0.0 -1.4
Illnesses of father: None of the above (group 1) 0.3 0.3 1.3 0.6 -0.5 0.4 -0.3 0.0 -0.3 0.6 1.1
Smoking status: Current 0.1 0.1 0.3 0.3 -0.5 0.1 -0.2 -0.5 -0.1 0.5 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.2 1.1 -1.5 -1.0 -1.0 0.1 -0.5 -0.9 0.5
Whole body water mass 0.2 1.4 2.0 1.2 -1.4 -1.3 -1.4 -1.3 -1.3 -0.2 0.7
Leg predicted mass (right) 0.2 1.1 1.5 1.2 -1.0 -1.0 -1.2 -1.1 -1.2 0.0 1.2
Arm fat mass (left) 0.5 2.2 8.5 1.5 -0.7 -1.1 -1.8 -1.0 -1.1 0.4 2.9
Number of self-reported non-cancer illnesses 0.3 0.5 2.1 -0.4 -0.0 -0.2 0.2 -0.3 0.3 -1.0 -1.5
Average weekly champagne plus white wine intake 0.6 0.8 1.3 0.6 -0.8 -0.9 -0.9 -1.1 -1.2 -0.1 -1.1
Miserableness 0.7 1.2 2.6 -1.4 0.6 0.7 1.4 0.6 1.4 0.1 -1.6
Guilty feelings 0.3 0.4 1.2 -0.2 0.9 -0.1 0.2 0.7 0.7 -1.1 -0.1
Wears glasses or contact lenses 0.9 1.0 2.3 1.1 -1.0 -0.5 -0.9 -1.5 -1.4 0.8 0.3
Ever taken oral contraceptive pill 0.8 0.9 1.8 -0.7 0.7 1.0 0.7 1.4 1.1 1.3 0.6
Hearing aid user 1.4 1.6 6.7 1.0 -0.8 -0.8 -1.1 -2.6 -1.4 -0.1 -0.6
Mother’s age at death 0.3 0.3 0.9 0.2 -0.9 -0.4 -0.2 0.5 -0.5 0.6 0.9
Financial situation satisfaction 0.2 0.3 0.8 0.2 -0.6 -0.8 -0.5 -0.9 -0.3 -0.1 -0.4
Tinnitus: Yes, now most or all of the time 1.9 2.2 6.2 -1.7 0.9 1.6 2.0 0.2 0.9 -0.2 -2.5
Commuting to job workplace: Public transport 0.3 0.4 1.9 -0.4 -0.3 -0.2 0.3 1.4 0.7 -0.5 0.2
Eye problems/disorders: Glaucoma 0.5 0.5 2.0 -0.9 1.4 0.7 0.7 0.3 0.3 -0.1 0.4
Medication: Blood pressure 0.7 1.3 2.8 1.0 -1.7 -1.3 -1.2 -1.4 -0.6 0.5 0.9
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.1 -0.7 1.1 0.6 0.7 1.1 0.8 -0.1 -0.1
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.5 -0.1 -0.5 -0.4 0.1 -0.7 -0.0 0.4 -0.7
High cholesterol (Self-reported) 0.2 0.4 1.2 -0.5 -0.9 -1.1 0.0 0.3 0.4 0.4 -0.6
Medication: Bendroflumethiazide 0.6 0.9 2.1 0.5 -1.2 -0.9 -0.5 -1.4 -0.9 -0.7 -1.0
Medication: Paracetamol 0.5 0.7 4.0 -0.3 -0.3 0.1 -0.0 0.2 0.1 2.0 1.2
Medication: Lisinopril 0.6 0.8 1.6 1.0 -0.9 -1.0 -1.0 -0.2 -0.7 0.1 1.3
Medication: Atorvastatin 2.3 2.8 4.6 -2.2 1.9 1.2 1.9 1.5 2.0 1.8 -0.5
Illnesses of father: High blood pressure 0.1 0.2 0.7 -0.3 -0.3 -0.1 0.0 0.7 0.4 0.8 0.0
Alcohol drinker status: Never 0.2 0.3 0.5 0.7 0.5 0.5 -0.4 -0.4 -0.6 -0.3 0.6
Ever smoked 0.7 1.3 1.9 -1.3 1.4 1.4 1.2 1.1 1.3 0.5 -0.3
Basal metabolic rate 0.3 1.4 2.0 1.3 -1.2 -1.2 -1.4 -1.2 -1.2 -0.0 1.2
Leg fat percentage (left) 0.7 2.5 9.2 1.5 -1.1 -1.4 -1.9 -0.9 -0.8 -0.0 3.0
Arm fat-free mass (left) 0.3 1.5 2.5 1.2 -1.6 -1.4 -1.4 -1.4 -1.3 -0.2 0.6
Number of operations (self-reported) 0.3 0.4 0.8 0.3 -0.7 -0.5 -0.2 -0.9 -0.8 -0.6 -0.9
Average weekly beer plus cider intake 0.4 0.6 2.0 0.4 -0.8 -1.4 -0.7 0.0 -0.0 -0.8 1.0
Irritability 0.9 1.5 4.2 -1.4 1.2 1.1 1.5 -0.0 0.4 0.9 -2.1
Risk taking 0.4 0.6 1.1 -0.6 0.4 0.8 0.5 0.8 1.0 1.1 0.9
Ever had prostate specific antigen (PSA) test 0.0 0.1 0.1 0.1 -0.0 0.4 0.3 0.3 0.2 0.2 -0.1
Fractured/broken bones in last 5 years 0.3 0.4 0.8 -0.6 0.8 0.9 0.7 0.3 0.4 0.2 -0.8
Age started oral contraceptive pill 0.2 0.2 0.8 -0.1 0.2 0.0 0.2 0.8 0.4 -0.5 0.9
Diastolic blood pressure, automated reading 0.3 0.9 6.0 -0.4 0.2 0.6 0.2 0.4 0.4 2.4 0.7
Ever depressed for a whole week 0.1 0.1 0.3 -0.3 0.2 0.2 0.3 -0.1 0.4 -0.5 0.6
Unable to work because of sickness or disability 0.3 0.4 2.4 -0.0 -0.1 -0.3 -0.2 -0.5 -0.2 1.6 0.2
Commuting to job workplace: Cycle 0.4 0.5 2.2 -0.6 0.5 0.7 0.6 0.3 0.7 -0.3 -1.5
Myopia 2.2 3.2 6.0 -1.7 2.1 2.4 2.2 1.7 1.8 -0.5 -0.8
Vascular/heart problems diagnosed by doctor 0.2 0.5 2.3 -0.2 0.4 0.5 0.4 0.9 0.4 -1.5 -0.5
Cholesterol lowering medication 0.3 0.4 1.9 0.3 -0.8 -1.4 -0.4 -0.5 0.0 -0.2 -0.0
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.5 -0.4 -0.7 -0.0 0.4 0.0 0.6 0.2 -0.7
Pain experienced in last month 0.5 0.8 1.3 -0.3 1.0 1.1 0.4 1.0 1.2 0.9 0.9
Supplements: Calcium 1.2 1.3 2.4 1.0 -1.6 -1.5 -1.3 -1.4 -1.0 -0.6 -0.4
Basal cell carcinoma (self-reported) 1.5 1.7 2.6 1.5 -1.5 -1.4 -1.6 -1.5 -1.6 0.3 0.3
Heart attack/myocardial infarction (self-reported) 1.4 1.8 4.5 1.2 -1.2 -1.2 -1.4 -2.1 -1.7 0.8 0.3
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.7 0.3 -0.8 -0.0 -0.4 -1.3 -0.6 1.2 -0.2
Heart disease (siblings) 0.6 0.8 3.5 -0.3 1.3 0.4 0.1 0.4 0.5 -0.3 1.9
Alcohol drinker status: Previous 5.8 6.6 14.3 2.1 -1.8 -3.0 -2.3 -3.8 -3.1 -1.4 -2.2
Pack years of smoking 1.6 2.3 4.6 1.5 -2.1 -2.0 -1.7 -1.5 -1.5 0.4 0.6
Impedance of whole body 1.0 5.3 11.9 -2.3 3.5 2.6 2.4 2.3 2.4 1.1 -0.1
Leg fat mass (left) 0.7 2.9 8.5 1.8 -1.2 -1.7 -2.1 -1.2 -1.3 -0.1 2.9
Arm predicted mass (left) 0.4 2.0 3.2 1.4 -1.8 -1.6 -1.6 -1.7 -1.5 -0.5 0.6