Hub : Genes

SNCA

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.07 0.025 1.7e-04 0.032 0.030 0.030 0.031 0.036 8.0e-05 1.1e-04 1.4e-04 1.1e-04 2.6e-05
2 GTEx Artery Aorta 0.09 0.037 3.8e-03 -0.005 NA 0.015 NA -0.005 7.5e-01 NA 4.9e-02 NA 7.8e-01
3 GTEx Artery Tibial 0.06 0.026 7.5e-03 0.048 NA 0.027 NA 0.035 1.2e-04 NA 3.3e-03 NA 9.0e-04
4 GTEx Brain Caudate basal ganglia 0.23 0.087 4.1e-03 -0.006 NA -0.007 NA -0.004 5.2e-01 NA 6.0e-01 NA 4.2e-01
5 GTEx Heart Left Ventricle 0.16 0.057 3.7e-05 0.152 NA 0.109 NA 0.142 1.8e-08 NA 2.2e-06 NA 5.3e-08
6 NTR Blood 0.04 0.011 2.5e-06 0.033 0.024 0.028 0.028 0.030 8.2e-11 2.0e-08 1.3e-09 1.3e-09 3.7e-10
7 YFS Blood 0.07 0.016 2.2e-16 0.076 0.057 0.070 0.070 0.073 1.4e-23 5.9e-18 4.9e-22 8.8e-22 1.2e-22
8 TCGA Breast Normal 0.05 0.014 6.9e-12 0.051 0.050 0.043 0.048 0.047 1.5e-13 2.8e-13 1.5e-11 9.0e-13 1.5e-12
9 TCGA Prostate Tumor 0.08 0.022 2.1e-07 0.098 0.059 0.095 NA 0.081 1.5e-12 5.4e-08 3.6e-12 NA 1.5e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Alzheimer’s Disease (in mother) 0.2 0.2 1.2 0.2 -1.1 -0.2 -0.1 -0.2 -0.1 -0.2 0.8 -0.0
Alzheimer’s Disease (in father) 1.2 1.3 5.0 1.1 1.3 1.0 0.0 1.3 0.1 -0.2 -2.2 1.1
Alzheimer’s Disease (including proxy) 0.7 1.0 2.7 1.7 0.6 0.7 0.2 1.3 0.4 0.1 -1.6 1.2
Crohns Disease (2017) 0.7 1.5 4.9 -0.9 -2.2 -1.2 1.3 -0.9 0.9 1.3 0.8 -0.8
Irritable Bowel Disease (IBD) 0.1 0.2 0.6 0.3 -0.7 0.0 -0.1 -0.2 0.5 0.8 -0.2 -0.0
Ulcerative Colitis (UC) 0.5 1.0 2.6 1.6 1.0 0.8 -1.1 0.2 0.7 0.8 -1.3 0.2
Major Depression (MDD) 0.9 1.0 4.0 -0.4 -0.5 0.7 -2.0 1.0 -0.3 -0.7 -1.4 1.0
Reaction Time 1.3 2.5 5.7 -1.4 -1.9 -1.6 -0.2 -2.4 0.4 0.5 2.1 -2.0
Verbal and Numeric Reasoning (VNR) 0.4 1.0 3.8 0.8 0.7 0.5 -1.9 0.8 -0.7 -0.6 -1.3 0.6
Breast Cancer 0.2 0.4 1.4 0.4 1.0 -0.4 0.4 -0.5 -0.1 0.4 1.2 -0.7
Ovarian Cancer 2.5 3.3 10.6 1.7 2.0 1.3 -1.0 2.0 1.6 1.3 -3.3 1.1
Prostate Cancer 1.3 1.9 3.9 -0.6 -1.4 -1.6 2.0 -1.2 1.1 1.5 0.8 -1.7
Age at First Birth 0.2 0.2 0.9 -0.0 -0.1 0.2 0.0 0.1 -1.0 -0.7 0.6 0.4
Bipolar Disorder 0.5 0.4 2.3 -1.5 -0.6 -0.7 0.0 -0.5 -0.7 -0.3 0.2 -0.2
Body Mass Index (BMI) (2010) 0.3 0.4 0.9 0.4 0.8 -0.2 -0.5 -0.7 1.0 1.0 0.2 -0.8
Coronary Artery Disease (CAD) 0.5 0.6 3.3 0.6 -0.3 0.2 1.8 -0.2 0.7 -0.1 -0.9 -0.4
Crohns Disease (2012) 0.2 0.4 1.5 1.0 1.2 0.0 -0.7 -0.2 0.5 0.3 0.1 -0.5
Mean Putamen Volume 0.4 0.5 1.3 0.5 -0.2 -0.3 0.2 -1.1 0.5 0.3 1.0 -1.1
Fasting Glucose 0.2 0.3 0.5 -0.5 0.6 0.1 0.4 0.3 -0.7 -0.6 -0.5 0.5
HbA1C 2.9 3.2 7.6 0.2 1.1 1.9 -0.6 2.0 -2.4 -2.8 -1.6 1.8
HDL Cholesterol 0.6 0.9 3.1 -0.3 -0.1 -1.1 1.8 -1.0 0.9 0.9 0.7 -0.9
LDL Cholesterol 0.2 0.3 1.3 0.4 -0.5 0.3 -1.1 0.5 0.0 -0.0 -0.5 0.4
Lupus 0.5 0.8 2.1 -0.1 0.5 0.5 1.1 0.5 -1.4 -1.3 -0.5 0.9
Neuroticism 6.3 9.3 17.7 0.4 1.0 2.2 -2.7 3.5 -4.2 -3.2 -3.5 4.1
Primary Biliary Cirrhosis 0.1 0.2 0.5 -0.3 -0.4 0.3 0.4 0.3 0.7 0.4 -0.3 0.3
Rheumatoid Arthritis 0.1 0.2 0.5 0.4 -0.7 -0.4 -0.5 0.1 0.3 0.6 0.3 -0.2
Schizophrenia 1.7 3.8 7.3 -2.7 -2.2 -2.1 2.3 -2.0 0.6 0.8 2.0 -1.9
Triglycerides 0.5 0.7 1.8 -1.3 0.5 0.5 -1.2 0.6 -0.9 -1.0 -0.3 0.9
Type 2 Diabetes (T2D) 1.5 1.7 8.1 2.8 1.1 2.0 -0.3 0.9 0.1 -0.3 -0.4 1.0
Ulcerative Colitis 0.2 0.4 1.9 -0.6 -1.4 -0.8 -0.4 0.3 0.1 0.1 0.4 -0.0
Blood Eosinophil Count 0.1 1.0 2.8 1.2 1.1 1.7 -0.9 0.8 -0.5 -0.7 0.1 1.0
Blood Platelet Count 0.1 0.7 3.4 -1.8 -0.4 -1.3 0.2 -0.7 0.6 0.3 0.7 -0.1
Blood Red Count 0.6 5.6 11.0 2.5 1.3 3.3 -1.6 3.2 -1.7 -1.9 -1.9 3.0
Blood White Count 0.1 0.9 3.3 0.3 0.1 -0.3 0.6 -1.0 1.1 0.5 1.8 -1.2
Heel T-Score 0.1 1.2 2.6 -0.2 -1.1 -0.8 1.1 -1.4 1.2 1.6 0.3 -1.0
BMI 0.5 3.2 10.0 3.2 1.1 0.4 -0.4 -1.0 2.8 2.7 0.3 -1.2
Height 0.7 14.2 22.2 -2.9 -3.8 -4.3 2.2 -4.7 3.2 3.3 4.0 -4.7
Waist Hip Ratio (WHR) 0.3 1.6 3.4 0.0 -0.2 1.1 -1.1 1.6 -1.6 -1.8 -0.7 1.6
Systolic Blood Pressure 0.4 2.2 5.3 0.6 -2.3 -1.0 1.8 -1.4 1.4 1.5 1.0 -1.7
Smoking Status 0.8 1.9 4.0 -2.0 -1.6 -1.6 1.3 -1.3 -0.6 -0.5 1.7 -1.2
Allergy or Eczema 0.2 0.5 1.5 1.2 0.7 0.2 1.0 -0.1 0.5 0.7 -0.3 -0.5
Cardiovascular Disease 0.3 0.9 3.0 0.6 -0.4 0.9 -0.6 0.5 -1.7 -1.5 0.9 0.5
Hypothyroidism (self reported) 1.0 2.2 5.8 -0.5 -1.4 -1.1 1.2 -1.2 2.3 2.4 0.6 -1.4
Respiratory disease 0.4 0.8 2.6 1.4 1.6 0.2 -0.4 0.3 0.3 0.5 -1.3 0.2
Type 2 Diabetes (T2D) 0.2 0.4 1.2 1.0 0.9 1.1 -0.6 0.3 -0.2 -0.2 -0.2 0.3
Lung FEV1/FVC ratio 1.1 5.6 12.0 -0.9 -2.5 -2.2 3.5 -2.4 1.6 1.7 2.9 -2.5
Lung FVC 0.5 2.5 6.9 -2.6 -1.2 -1.5 1.1 -1.7 -1.6 -1.5 1.3 -1.2
Neuroticism 8.0 19.7 33.5 3.3 3.7 4.9 -3.2 5.8 -4.0 -3.8 -5.0 5.4
Chronotype (morning person) 0.5 1.2 3.9 2.0 1.7 0.7 -1.4 -0.1 1.0 0.8 0.3 -0.1
Hair Pigment 0.0 1.1 7.4 1.2 -0.2 -0.4 -2.7 -0.2 0.4 0.0 0.6 -0.5
Tanning 0.4 5.8 9.1 -2.9 -3.0 -2.8 1.9 -2.6 1.5 1.9 2.3 -2.5
Hand grip strength (left) 0.4 1.0 3.2 -1.0 0.5 0.4 -0.9 0.5 -1.8 -1.7 -0.5 0.8
Number of treatments/medications taken 3.2 5.7 12.3 -3.4 -2.3 -3.5 0.4 -2.6 1.1 1.4 2.7 -2.3
Average weekly spirits intake 2.2 2.7 5.8 0.8 1.1 1.8 -0.6 2.4 -1.0 -1.2 -2.3 2.2
Sensitivity / hurt feelings 2.0 3.6 9.7 -1.1 -0.8 -1.5 3.1 -2.3 1.6 1.4 2.1 -2.1
Frequency of depressed mood in last 2 weeks 2.3 3.2 6.5 -1.9 -1.5 -2.0 1.9 -2.6 0.5 0.2 2.0 -2.0
Hearing difficulty/problems: Yes 0.2 0.3 1.1 -0.4 -0.0 0.2 1.1 -0.3 0.8 0.5 -0.1 0.1
Relative age of first facial hair 1.7 3.6 10.5 1.5 -0.9 -1.5 1.2 -1.4 2.9 3.2 0.8 -2.1
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.1 0.1 0.4 0.7 -0.5 1.2 -1.2 -1.3 -0.8 1.5
Ever used hormone-replacement therapy (HRT) 2.1 2.7 6.8 0.8 -1.0 -1.5 1.3 -1.4 2.5 2.6 0.8 -1.8
Ever had hysterectomy (womb removed) 0.2 0.2 0.6 0.2 0.7 0.1 0.5 0.0 0.4 0.5 0.8 0.2
Systolic blood pressure, automated reading 0.1 0.4 2.0 -1.4 0.6 -0.3 -1.0 -0.0 -0.1 -0.2 -0.0 0.1
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 0.9 -0.7 -0.9 0.0 0.0 0.7 -0.7 -0.6 0.2 0.6
Angina 0.9 1.2 6.7 -2.6 -0.4 -1.2 -1.1 -0.3 -0.9 -0.6 0.2 -0.2
Medication for hormone replacement therapy 0.2 0.3 0.8 0.1 0.4 0.0 -0.9 0.7 -0.2 -0.2 0.8 0.4
Vitamin and mineral supplements 3.6 4.9 8.5 -0.9 -2.0 -2.5 1.5 -2.5 2.6 2.7 1.2 -2.9
Supplements: Zinc 0.3 0.3 1.0 1.0 1.0 0.1 0.7 0.3 0.0 -0.2 -0.1 0.3
Medication: Co-codamol 0.8 0.9 2.1 -0.7 -1.5 -1.1 0.9 -1.0 0.9 1.0 0.2 -1.0
Medication: Metformin 0.5 0.7 2.0 -1.4 -1.1 -0.9 1.3 -0.2 0.3 0.4 -0.0 -0.5
Diabetes (father) 0.5 0.6 1.7 0.6 1.3 0.6 -0.1 0.5 -0.9 -1.1 -0.6 0.8
Diabetes (mother) 0.4 0.5 1.4 -0.2 -0.9 -0.3 0.1 -0.7 0.9 1.2 0.4 -1.0
Severe depression (siblings) 1.2 1.4 4.6 -0.9 -0.6 0.7 0.4 1.1 -2.1 -1.8 -0.3 1.1
Pack years adult smoking proportion 2.6 3.9 6.1 -2.2 -2.0 -2.3 2.2 -2.5 0.4 0.4 2.5 -2.1
Impedance of leg (right) 0.9 4.6 9.6 1.8 0.2 -1.1 1.2 -2.8 3.1 3.0 1.0 -2.8
Leg fat-free mass (left) 1.1 6.0 16.5 -2.3 -0.1 1.0 -0.6 2.6 -4.1 -3.8 -1.5 2.8
Trunk fat percentage 0.3 1.1 4.2 -2.1 -0.4 -1.0 0.3 -0.1 -1.6 -1.4 -0.1 -0.1
Hand grip strength (right) 0.1 0.3 1.0 -1.0 -0.2 -0.4 -0.5 -0.7 -0.6 -0.4 0.2 -0.6
Townsend deprivation index at recruitment 2.1 2.9 9.0 -1.8 0.3 0.4 3.0 0.3 -2.7 -2.5 0.0 0.8
Current tobacco smoking 0.7 1.1 2.3 0.8 0.9 1.0 -1.1 1.5 -0.9 -0.7 -0.4 1.5
Average weekly fortified wine intake 1.2 1.4 2.6 1.2 0.5 1.3 -1.5 1.6 -0.2 -0.2 -1.6 1.4
Maternal smoking around birth 1.4 2.1 4.1 -1.1 -1.2 -1.1 2.0 -2.0 0.7 0.7 1.5 -2.0
Fed-up feelings 2.4 4.5 7.3 -1.8 -2.1 -2.2 2.7 -2.5 1.3 1.1 2.6 -2.2
Frequency of unenthusiasm / disinterest in last 2 weeks 3.1 4.2 7.8 -2.5 -1.8 -2.8 1.8 -2.5 0.5 0.7 2.2 -2.2
Relative age voice broke 2.0 3.1 8.0 0.9 -1.5 -1.2 0.9 -1.5 2.8 2.7 1.0 -1.9
Taking other prescription medications 2.4 3.8 8.4 -2.2 -2.3 -2.9 0.7 -2.1 1.1 1.4 1.9 -2.0
Age when periods started (menarche) 0.8 1.8 7.4 0.5 -0.2 -0.4 -1.4 -0.8 2.7 2.1 -0.2 -1.4
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.8 0.1 -0.3 -0.7 0.9 -0.8 0.2 0.4 0.7 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.7 -0.4 -0.3 -0.9 -1.3 -0.7 1.2 0.8 -0.2 -0.9
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 2.9 -0.4 -0.1 -0.4 0.1 -0.7 -1.6 -1.7 0.9 -0.2
Qualifications: CSEs or equivalent 0.1 0.2 0.6 -0.3 -0.2 -0.0 0.7 -0.8 -0.0 -0.0 0.3 -0.4
Serious illness, injury or assault to yourself 0.3 0.3 0.9 -0.5 -0.6 0.1 -0.7 0.5 -0.6 -0.9 0.3 0.7
High blood pressure 0.5 1.5 3.3 -1.7 -0.2 -1.8 0.4 -1.3 1.3 1.4 0.5 -1.2
Hayfever, allergic rhinitis or eczema 0.4 0.8 3.2 -1.8 -1.2 -0.7 0.1 -0.4 -0.9 -1.0 0.2 0.2
Multivitamins +/- minerals 3.4 4.3 6.2 0.7 2.4 2.4 -1.9 1.9 -2.5 -2.5 -0.9 2.4
Stomach or abdominal pain in last month 2.9 3.6 5.8 -2.1 -2.0 -2.2 1.2 -2.4 1.1 1.1 2.1 -2.1
Supplements: Glucosamine 1.9 2.4 7.7 1.0 0.9 2.0 -2.8 1.3 -0.9 -1.4 -0.8 1.7
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.1 -0.9 -0.1 0.0 -0.8 0.3 -0.8 -1.0 0.1 0.5
Medication: Atenolol 0.8 1.0 6.8 -0.2 -0.8 -0.6 -2.6 -0.2 0.7 0.6 0.4 -0.4
Medication: Levothyroxine sodium 0.5 0.8 2.5 0.3 1.6 0.6 -0.9 0.2 -1.3 -1.2 0.1 0.3
Sitting height 0.4 2.9 7.3 -0.3 0.9 0.8 0.2 1.8 -2.7 -2.5 -1.7 2.1
Chronic bronchitis/emphysema (father) 1.7 2.0 4.7 -1.8 -1.6 -1.4 -0.1 -1.6 -0.5 -0.2 2.2 -1.4
High blood pressure (mother) 0.6 0.8 2.0 -1.3 -0.7 -0.8 -0.6 0.1 -1.4 -1.2 0.6 0.2
Body mass index (BMI) 0.8 3.6 16.4 -4.1 -2.2 -1.9 0.1 -1.1 -1.5 -1.3 1.3 -0.9
Impedance of leg (left) 0.7 3.7 7.1 2.1 0.5 -0.8 1.1 -2.4 2.7 2.6 1.0 -2.4
Leg predicted mass (left) 1.1 6.0 16.9 -2.4 -0.1 0.9 -0.4 2.5 -4.1 -3.9 -1.4 2.7
Trunk fat mass 0.5 2.0 6.2 -2.4 -0.3 -0.7 0.2 0.5 -2.5 -2.3 -0.5 0.6
Waist circumference 0.8 2.9 11.7 -3.4 -1.3 -1.4 0.1 -0.7 -2.3 -1.9 1.0 -0.3
Number of incorrect matches in round 2.3 3.9 8.3 2.4 1.8 2.0 -1.8 2.4 0.5 0.5 -2.9 2.0
Past tobacco smoking 0.9 1.7 5.3 -2.0 -2.3 -1.3 1.0 -0.8 -0.9 -0.7 1.2 -0.6
Alcohol usually taken with meals 0.6 0.9 2.0 1.2 1.0 0.9 -0.1 1.1 -0.8 -0.4 -1.4 1.1
Nervous feelings 6.4 12.2 23.1 -3.7 -3.4 -3.8 2.2 -4.8 1.9 2.1 4.0 -4.3
Frequency of tenseness / restlessness in last 2 weeks 3.9 6.1 11.4 -2.6 -2.6 -2.8 1.9 -3.4 1.7 1.6 2.1 -3.0
Hearing difficulty/problems with background noise 1.1 1.7 3.4 1.0 1.6 1.8 0.4 1.4 -0.3 -1.0 -1.3 1.8
Hair/balding pattern: Pattern 2 1.8 2.3 5.5 -0.5 -2.4 -1.9 1.6 -1.7 0.7 0.8 1.7 -1.5
Had menopause 0.6 0.7 3.0 0.8 -0.2 0.2 -0.0 0.1 1.7 1.6 -0.3 -0.4
Had other major operations 0.2 0.3 0.8 0.0 -0.5 0.3 0.9 0.9 -0.2 -0.1 -0.5 0.5
Forced vital capacity (FVC) 0.4 1.5 3.7 1.9 1.9 1.3 -0.1 1.3 -0.3 -0.5 -0.9 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.8 -0.1 0.9 -0.1 -0.9 -0.1 -0.0 -0.5 -0.5 -0.2
Ever unenthusiastic/disinterested for a whole week 2.5 3.1 8.1 -1.8 -0.9 -1.2 2.1 -2.0 -1.4 -1.2 2.9 -1.4
Qualifications: None of the above 0.3 0.6 3.2 -0.2 -0.6 -0.5 -0.5 -0.0 -1.8 -1.0 0.8 -0.0
Financial difficulties in last 2 years 0.7 1.0 3.7 -1.9 -0.2 -0.7 1.4 -0.7 -0.9 -1.1 0.8 -0.4
Mouth/teeth dental problems 1.5 2.3 3.9 1.3 1.3 1.8 -2.0 1.9 -1.3 -1.2 -1.0 1.7
Heart attack 1.7 2.1 5.7 -2.1 -0.7 -2.4 -0.2 -1.4 -0.5 -0.1 2.1 -1.4
Allergy 0.7 1.6 5.2 2.3 1.2 0.8 -0.4 0.3 1.7 1.8 -0.5 -0.4
Pain all over the body in last month 1.9 2.0 6.6 -1.0 -0.6 0.3 1.4 0.6 -2.5 -2.6 -0.6 1.0
Diabetes (self-reported) 0.2 0.2 0.8 -0.8 -0.2 -0.9 0.5 -0.0 0.3 0.5 0.3 -0.2
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 5.2 -2.3 -1.6 -1.5 0.2 -1.1 -1.1 -0.8 1.2 -0.8
Medication: Ramipril 0.2 0.2 0.6 0.8 0.6 0.1 -0.4 0.5 0.3 0.6 -0.3 0.4
Medication: Simvastatin 0.8 1.1 3.3 -0.4 0.6 0.7 -1.8 1.0 -1.2 -1.0 -0.8 1.3
Fluid intelligence score 0.9 1.8 7.2 -1.0 -1.1 -1.1 2.7 -1.2 0.3 0.5 1.5 -1.1
Illnesses of siblings 0.4 0.6 2.2 -0.5 0.2 0.5 0.4 0.5 -1.3 -1.5 0.1 0.5
Neuroticism score 5.6 12.0 21.0 -2.6 -2.2 -3.7 3.7 -4.6 2.9 2.8 3.8 -4.2
Weight 0.7 3.6 10.7 -3.1 -0.8 -0.4 -0.3 0.8 -3.3 -3.0 -0.4 1.1
Impedance of arm (right) 0.3 1.4 6.9 2.6 1.6 0.5 -0.1 0.1 1.2 1.1 -0.6 -0.2
Arm fat percentage (right) 0.7 2.9 12.8 -3.6 -1.8 -2.0 0.0 -1.0 -1.4 -1.1 0.9 -0.9
Trunk fat-free mass 0.9 5.0 12.8 -1.6 0.2 1.2 -0.6 2.3 -3.6 -3.5 -1.7 2.6
Hip circumference 0.6 2.7 9.1 -3.0 -1.4 -1.0 0.5 -0.0 -2.6 -2.3 0.3 0.2
Time employed in main current job 1.0 1.1 2.2 0.1 0.6 0.9 -0.8 1.5 -1.2 -1.3 -1.1 1.3
Alcohol intake versus 10 years previously 0.4 0.5 2.0 -1.4 0.1 -0.8 0.6 -0.5 0.4 0.4 0.8 -0.7
Father’s age at death 0.9 1.2 5.3 2.3 0.8 0.8 -1.3 1.2 -0.1 0.2 0.2 0.7
Worrier / anxious feelings 3.8 7.3 12.3 -2.4 -1.6 -3.0 2.9 -3.5 1.6 2.0 3.2 -3.3
Frequency of tiredness / lethargy in last 2 weeks 3.2 5.2 9.7 -1.6 -2.2 -2.4 2.2 -3.1 1.1 1.4 2.8 -2.9
Falls in the last year 0.3 0.4 2.5 -0.5 -0.5 -0.2 1.6 -0.1 -0.4 -0.3 -0.8 -0.1
Hair/balding pattern: Pattern 3 0.5 0.7 2.1 -0.4 0.6 1.0 -0.7 1.4 -0.5 -0.5 -0.4 1.2
Number of live births 0.2 0.3 1.8 0.1 1.3 -0.1 0.1 -0.3 -0.8 -0.3 0.2 0.0
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 6.2 1.9 2.5 1.6 -1.0 1.4 -0.8 -1.1 -1.3 1.4
Pulse rate 0.5 0.8 1.4 -0.5 -1.1 -1.1 -0.5 -1.1 0.9 1.2 0.3 -1.0
Happiness 2.1 2.6 5.3 -2.0 -2.2 -1.7 1.3 -1.5 0.3 0.4 2.3 -1.3
Noisy workplace 0.5 0.6 2.6 -0.3 0.3 -0.7 -1.6 -0.8 0.6 0.5 -0.3 -1.0
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.4 0.7 0.6 0.0 1.2 -0.1 1.0 0.8 -0.6 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 2.5 1.2 1.6 0.4 0.9 -0.0 -0.1 -0.1 -0.4 -0.0
Mouth/teeth dental problems: Dentures 1.4 2.3 6.7 -1.4 -2.6 -1.6 0.4 -1.1 1.8 1.4 0.9 -1.3
Asthma 0.6 1.1 2.5 -1.6 -1.4 -0.7 0.9 -0.6 -0.8 -0.9 1.3 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 5.9 0.7 2.4 0.7 0.2 1.1 -0.7 -0.6 -0.8 0.9
Medication: Cholesterol lowering 0.8 1.2 5.6 -0.8 0.3 0.0 -2.4 0.4 -1.4 -1.1 0.4 1.0
Depression (self-reported) 5.1 6.1 10.4 -3.0 -2.4 -3.2 1.5 -3.2 0.9 1.0 2.6 -2.9
Medication: Lansoprazole 2.9 3.3 6.2 0.1 -1.4 -2.3 -0.6 -2.1 2.2 2.5 1.1 -2.3
Prospective memory result 0.2 0.3 2.0 1.4 0.4 -0.1 -0.5 0.2 0.1 0.1 0.3 0.1
Lung cancer (father) 0.4 0.5 3.1 -0.5 -0.1 -0.1 1.7 -0.6 0.0 0.1 -0.3 -0.6
Illnesses of mother 0.3 0.3 1.2 0.9 1.1 0.7 -0.2 0.4 -0.3 -0.4 -0.2 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 3.6 1.8 1.9 1.6 -0.2 1.6 -0.2 -0.4 -1.9 1.4
Pulse wave Arterial Stiffness index 0.5 0.6 1.2 -0.5 -0.4 -0.6 1.1 -0.6 1.1 0.8 1.0 -0.6
Impedance of arm (left) 0.5 2.5 11.3 3.4 2.2 1.1 0.2 0.6 1.4 1.2 -1.1 0.2
Arm fat mass (right) 0.7 2.8 11.8 -3.4 -1.7 -1.3 0.1 -0.2 -2.2 -2.0 0.4 -0.1
Trunk predicted mass 0.8 4.9 12.4 -1.7 0.2 1.2 -0.5 2.3 -3.5 -3.5 -1.7 2.6
Standing height 1.2 12.0 19.4 2.0 2.9 3.5 -0.8 4.3 -3.9 -3.9 -3.9 4.4
Length of working week for main job 1.2 1.3 3.1 -1.3 -1.1 -1.8 0.6 -1.2 0.5 0.6 1.2 -1.4
Exposure to tobacco smoke at home 0.2 0.2 0.7 0.5 -0.5 0.1 0.8 0.4 0.5 0.3 -0.3 0.0
Breastfed as a baby 0.4 0.5 1.3 0.1 -0.7 -0.5 -0.7 -0.9 0.6 0.7 0.6 -1.1
Tense / ‘highly strung’ 2.4 4.0 7.0 -1.2 -1.9 -1.7 2.0 -2.6 2.2 1.9 1.8 -2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.6 2.9 -1.0 -0.1 -1.3 1.5 -1.4 1.4 1.1 1.7 -1.5
Hair/balding pattern: Pattern 4 0.2 0.4 1.6 0.1 -0.3 0.6 -1.3 0.5 -0.7 -0.8 -0.3 0.7
Birth weight of first child 0.2 0.3 0.8 -0.4 0.1 0.4 -0.9 0.9 -0.1 -0.4 -0.4 0.6
Peak expiratory flow (PEF) 0.2 0.4 1.4 -0.0 1.2 0.1 -0.3 -0.9 -0.6 -0.7 0.6 -0.6
Pulse wave reflection index 0.5 0.6 1.7 0.8 1.3 0.5 0.3 0.2 1.3 0.8 0.3 -0.0
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.4 -0.6 -0.3 -1.0 -0.2 -1.2 0.1 -0.0 0.4 -1.0
Loud music exposure frequency 0.5 0.5 1.7 0.0 0.5 0.4 0.5 0.7 -1.1 -0.7 -1.3 0.7
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 4.8 -0.4 -0.2 -0.3 2.2 -1.0 0.5 0.1 0.2 -0.7
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 3.0 0.7 1.4 0.9 -0.5 0.8 -0.8 -1.0 -1.7 1.1
Blood clot in the leg (DVT) 0.6 0.7 1.5 0.1 1.2 0.7 -0.9 0.7 -1.0 -1.2 -0.5 0.9
Medication: Paracetamol 1.7 2.8 4.8 -0.6 -2.2 -1.7 1.4 -1.6 1.9 2.0 1.4 -1.9
Headache pain in last month 0.9 1.5 2.9 -1.1 -1.4 -1.3 0.8 -1.7 1.0 0.7 1.2 -1.6
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.1 1.3 0.3 0.6 1.4 -0.2 -0.1 -0.0 0.3 -0.6
Glaucoma (self-reported) 0.5 0.6 1.8 0.2 -1.0 0.2 1.3 0.1 -1.1 -1.1 -0.0 0.4
Gout (self-reported) 1.3 1.8 4.3 0.8 0.3 0.9 -2.0 0.9 -2.1 -1.9 -0.6 1.1
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.5 1.1 1.6 1.2 -0.6 0.8 -1.4 -1.6 -0.6 0.9
Medication: Amlodipine 0.5 0.8 1.8 -1.3 0.5 -1.2 0.5 -1.3 -0.0 -0.0 0.5 -1.2
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.6 -1.3 -0.9 -0.2 -1.3 -0.0 0.0 -0.2 0.0 -0.2
Birth weight 0.6 1.3 2.5 -1.2 -1.2 -1.1 -1.1 -0.8 -1.4 -0.8 1.6 -0.7
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.6 -0.3 0.4 0.4 0.0 -0.1 -0.8 -0.7 -0.8 -0.1
High blood pressure (siblings) 0.5 0.7 1.3 0.5 1.2 0.9 -0.8 0.9 -0.1 -0.3 -1.1 1.0
Forced vital capacity (FVC), Best measure 0.7 2.7 5.4 2.3 1.9 1.9 0.1 2.1 -0.3 -0.5 -1.8 1.9
Body fat percentage 0.5 2.1 8.3 -2.9 -1.3 -1.8 0.4 -1.1 -1.2 -1.0 0.8 -1.1
Leg fat percentage (right) 1.7 6.2 16.1 -4.0 -2.7 -3.3 0.5 -2.9 -0.0 0.4 2.2 -2.7
Arm fat-free mass (right) 0.8 4.1 11.0 -2.0 -0.2 0.9 0.1 1.9 -3.3 -3.2 -1.4 2.2
Exposure to tobacco smoke outside home 0.3 0.4 1.6 -1.3 -0.0 -0.5 0.9 0.1 0.6 0.3 -0.1 -0.1
Comparative body size at age 10 0.9 2.4 7.8 -0.3 1.2 0.9 -1.0 1.3 -2.8 -2.6 0.2 1.4
Number of full brothers 0.8 1.1 2.6 -1.6 -1.0 -1.0 0.5 -1.0 -0.5 -0.3 1.6 -0.9
Worry too long after embarrassment 3.1 5.3 11.4 -1.4 -1.3 -2.5 3.4 -2.9 1.7 2.1 1.7 -2.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 3.1 -1.5 -0.4 -1.0 1.8 -1.4 0.2 0.1 1.5 -1.1
Wheeze or whistling in the chest in last year 1.4 2.5 5.7 -2.4 -2.3 -1.8 1.4 -1.6 -0.4 0.0 1.2 -1.3
Number of children fathered 0.1 0.1 0.6 0.7 -0.1 -0.2 0.5 -0.2 -0.0 -0.4 0.1 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.8 -0.6 0.1 0.6 0.4 0.8 -0.8 -0.3 -0.6 0.9
Age at first live birth 1.2 2.2 8.1 2.8 0.4 0.9 -1.0 0.9 1.8 1.6 -1.8 0.4
Pulse wave peak to peak time 0.7 0.8 1.9 0.5 0.5 0.7 -1.0 0.7 -1.4 -1.0 -1.2 0.9
Health satisfaction 3.3 4.3 7.9 -2.7 -2.7 -2.6 1.4 -1.9 0.7 0.6 2.8 -1.8
Shortness of breath walking on level ground 0.9 1.1 2.6 -0.8 -0.4 -1.0 1.6 -1.3 0.7 0.5 1.3 -1.2
Qualifications: College or University degree 0.7 2.4 10.4 1.8 0.2 0.0 1.1 0.1 3.2 2.4 -0.8 -0.2
Eye problems/disorders: None of the above 0.1 0.1 0.4 -0.5 -0.2 -0.0 -0.7 -0.2 -0.4 -0.3 0.3 0.2
Mouth/teeth dental problems: Loose teeth 0.7 0.8 3.0 -0.5 -0.8 -1.1 0.5 -1.7 0.1 0.5 0.9 -1.0
Emphysema/chronic bronchitis 0.2 0.2 0.5 -0.4 -0.3 0.0 0.4 0.5 -0.4 -0.6 -0.1 0.7
Medication for pain relief, constipation, heartburn 2.0 3.5 6.5 2.0 2.2 2.6 -0.9 2.2 -1.0 -1.2 -1.9 2.1
Neck or shoulder pain in last month 0.5 0.7 1.6 -1.3 -0.4 -0.7 -0.5 -1.2 0.1 0.2 1.2 -0.8
Medication: Blood pressure 0.3 0.5 2.1 -1.5 -0.5 -0.8 -0.7 0.0 0.3 0.2 -0.6 0.3
Angina (self-reported) 0.8 1.0 4.7 -2.2 0.0 -1.0 -1.4 -0.1 -1.0 -0.7 0.1 -0.0
Migraine (self-reported) 3.2 4.0 8.5 -1.1 -1.3 -2.0 1.5 -2.2 1.7 1.9 2.9 -2.5
Medication: Ibuprofen 0.7 0.8 3.2 0.6 1.8 0.4 0.6 1.1 -0.5 -0.4 -0.9 0.8
Medication: Allopurinol 0.7 0.9 4.2 1.2 0.7 0.6 -2.0 0.3 -0.7 -0.6 -0.8 0.3
Medication: Omeprazole 0.1 0.1 0.3 -0.6 -0.3 -0.4 -0.3 -0.3 0.1 0.3 0.4 -0.4
Medication: Seretide 50 evohaler 1.3 1.5 2.5 -0.4 0.5 0.7 1.2 1.6 -1.5 -1.6 -1.6 1.3
Mean time to correctly identify matches 1.4 2.6 5.8 1.7 2.0 1.6 -0.6 2.4 -0.1 -0.1 -2.0 2.0
Heart disease (mother) 0.7 0.8 3.1 -0.4 -0.9 -0.4 0.5 0.1 1.8 1.5 -0.9 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.4 3.7 -0.7 0.2 1.1 -1.9 0.5 -1.9 -1.4 -0.5 1.0
Whole body fat mass 0.6 2.4 9.4 -3.1 -1.0 -1.2 0.1 -0.2 -2.3 -2.0 0.3 -0.0
Leg fat mass (right) 0.9 3.5 15.8 -4.0 -1.9 -2.0 0.2 -1.1 -1.7 -1.3 1.0 -0.9
Arm predicted mass (right) 0.8 3.9 10.9 -1.8 -0.2 0.9 0.2 1.8 -3.3 -3.2 -1.5 2.1
Pulse rate, automated reading 0.4 1.3 4.2 0.3 1.3 1.0 -1.3 1.3 -0.2 0.1 -2.0 1.2
Alcohol intake frequency. 2.5 5.9 16.1 -1.5 -1.9 -2.4 4.0 -2.9 0.3 0.6 2.8 -2.9
Comparative height size at age 10 2.9 16.5 26.8 2.1 4.3 3.8 -2.4 4.9 -4.6 -4.3 -3.8 5.2
Number of full sisters 0.6 0.7 2.4 -1.6 -1.0 -0.5 0.7 -0.7 -0.9 -0.5 0.9 -0.4
Suffer from ‘nerves’ 2.9 4.6 9.8 -2.0 -2.1 -2.3 1.7 -3.1 1.4 1.6 1.9 -2.8
Overall health rating 5.2 11.3 27.7 -5.3 -3.9 -4.3 1.5 -3.8 0.5 1.1 3.3 -3.3
Chest pain or discomfort 2.6 3.8 6.9 -2.0 -1.1 -2.2 2.6 -2.6 0.2 0.3 2.4 -2.2
Had major operations 0.7 0.8 2.0 -1.2 -1.4 -1.0 0.2 -0.8 -0.7 -0.6 1.2 -0.6
Age at last live birth 0.4 0.6 1.5 1.2 0.4 -0.3 -0.4 -0.2 1.0 0.9 -1.2 -0.4
Family relationship satisfaction 0.9 1.1 2.3 -1.3 -0.9 -1.2 1.4 -0.9 -0.2 0.0 1.5 -1.1
Leg pain on walking 0.6 0.7 2.7 -0.0 1.6 0.6 -0.5 0.4 -1.0 -1.3 -0.3 0.7
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.0 5.7 -2.4 -1.7 -1.6 -0.7 -1.7 -0.1 0.0 1.4 -1.4
Commuting to job workplace: Car/motor vehicle 2.3 2.7 6.9 -1.6 -1.5 -2.0 0.2 -2.6 0.3 0.7 1.7 -2.3
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 4.0 1.7 -0.7 0.1 -0.5 0.1 1.7 2.0 -0.6 -0.3
Medication: Aspirin 1.4 1.8 4.6 -2.1 -1.5 -2.0 -0.2 -1.5 0.1 0.6 1.2 -1.3
Supplements: Vitamin C 1.0 1.2 2.7 -0.0 0.7 1.3 -0.6 1.3 -1.1 -1.0 -1.3 1.6
Knee pain experienced in last month 0.2 0.3 0.7 -0.7 -0.5 -0.2 -0.2 -0.7 -0.0 0.2 0.8 -0.6
Hypertension (Self-reported) 0.5 1.3 3.3 -1.8 -0.0 -1.6 0.0 -1.0 1.4 1.4 0.3 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.6 3.0 4.9 -1.1 -1.9 -1.8 -0.0 -2.2 1.9 1.7 1.6 -2.1
Illnesses of father: Heart disease 1.6 2.3 8.5 0.3 -0.0 -1.0 -0.2 -0.8 2.9 2.8 -0.4 -1.5
Illnesses of siblings: Diabetes 3.0 3.7 7.6 -1.8 -2.8 -2.6 0.9 -2.3 0.8 1.3 1.5 -2.2
Smoking status: Previous 0.9 1.3 4.4 1.9 2.1 1.1 -0.7 0.4 0.7 0.6 -1.2 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.2 2.7 0.2 0.8 0.7 0.2 1.6 -1.2 -1.3 -1.3 1.4
Whole body fat-free mass 1.0 5.9 16.4 -2.1 0.0 1.1 -0.5 2.4 -4.0 -3.9 -1.5 2.7
Leg fat-free mass (right) 1.1 6.2 17.1 -2.1 -0.0 1.0 -0.5 2.8 -4.1 -3.9 -1.4 2.9
Arm fat percentage (left) 0.5 2.2 10.2 -3.2 -1.4 -1.7 0.2 -0.7 -1.5 -1.2 0.6 -0.6
Average weekly red wine intake 2.5 3.7 7.8 2.4 1.7 2.3 -1.1 2.3 -0.4 -0.7 -2.8 2.2
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.6 0.4 -0.7 -0.0 -1.0 1.3 1.2 1.2 -0.9 0.7
Mood swings 5.7 10.6 18.7 -3.3 -3.1 -4.0 1.5 -4.3 1.9 1.8 4.1 -3.8
Loneliness, isolation 2.7 3.8 10.5 -1.9 -0.5 -1.4 3.2 -2.3 0.5 0.2 2.8 -2.0
Long-standing illness, disability or infirmity 0.8 1.2 2.6 -1.2 -1.6 -1.3 0.9 -1.0 0.5 0.7 1.2 -1.0
Ever had bowel cancer screening 1.3 1.5 2.8 -1.4 -1.5 -1.7 0.4 -1.7 0.5 0.5 1.2 -1.2
Diabetes diagnosed by doctor 0.9 1.5 3.6 -1.7 -1.2 -1.9 0.9 -1.1 0.4 0.7 1.2 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.3 -0.3 1.1 0.4 -0.2 0.6 -0.9 -0.6 0.2 0.5
Friendships satisfaction 0.2 0.2 0.9 0.0 -0.9 -0.7 0.4 -0.4 -0.1 -0.0 0.5 -0.4
Qualifications: nursing, teaching 0.1 0.2 0.6 0.2 -0.1 0.1 0.3 0.3 0.8 0.5 -0.7 0.2
Commuting to job workplace: Walk 2.0 2.2 4.1 2.0 1.7 2.0 -1.1 1.9 0.5 -0.1 -1.0 1.6
Eye problems/disorders: Cataract 0.3 0.3 1.0 0.3 0.5 0.7 -0.0 1.0 -0.4 -0.3 -0.7 0.6
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 3.8 -0.2 -0.7 -1.9 1.9 -1.9 1.6 1.9 1.5 -1.9
Medication for cholesterol 0.4 0.7 1.2 1.1 -0.2 0.9 0.4 0.7 -1.0 -0.9 -0.9 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.1 2.5 4.2 -1.6 -1.9 -1.8 0.7 -2.0 0.7 1.0 2.0 -1.6
Back pain experienced in last month 1.6 2.3 4.9 -1.6 -2.2 -1.6 0.8 -2.0 -0.0 0.2 1.8 -1.7
Mineral and other dietary supplements 5.7 7.7 12.6 -1.8 -3.5 -3.6 2.8 -3.0 1.6 2.2 2.2 -3.4
Breast cancer (self-reported) 0.5 0.6 2.0 0.9 1.4 0.5 -0.2 0.1 1.1 0.8 -0.4 -0.0
Asthma (self-reported) 0.7 1.3 3.0 -1.7 -1.7 -0.9 0.9 -0.9 -0.5 -0.6 1.4 -0.8
Osteoporosis (self-reported) 1.7 2.1 4.5 -1.1 -1.4 -1.6 0.3 -2.1 0.5 0.8 2.0 -1.9
Osteoarthritis (self-reported) 0.6 0.8 2.4 -0.4 0.5 0.4 -0.5 0.6 -1.4 -1.5 -0.8 1.0
Medication: Aspirin 1.4 1.9 5.7 -2.4 -1.4 -2.1 -0.4 -1.4 0.1 0.4 1.1 -1.2
Medication: Gliclazide 0.4 0.5 1.3 0.2 0.3 -0.3 1.1 0.5 0.8 0.8 -1.2 0.0
Illnesses of father: None of the above (group 1) 1.0 1.2 2.9 0.8 0.6 1.7 1.1 1.0 -0.9 -1.2 -1.0 1.2
Smoking status: Current 0.8 1.3 2.7 0.8 1.0 1.2 -1.3 1.6 -0.8 -0.8 -0.6 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 3.8 2.0 0.7 1.1 -1.0 1.3 1.3 1.3 -1.2 0.8
Whole body water mass 1.0 5.9 15.7 -2.0 0.1 1.2 -0.4 2.5 -4.0 -3.8 -1.7 2.8
Leg predicted mass (right) 1.1 6.0 16.5 -2.1 -0.1 1.0 -0.4 2.7 -4.1 -3.9 -1.3 2.8
Arm fat mass (left) 0.6 2.5 10.9 -3.3 -1.5 -1.1 0.1 -0.0 -2.1 -1.9 0.1 0.1
Number of self-reported non-cancer illnesses 4.9 8.5 15.0 -3.6 -3.0 -3.9 1.8 -3.1 1.8 1.7 3.4 -3.0
Average weekly champagne plus white wine intake 0.5 0.8 2.4 0.6 -0.8 0.1 1.6 0.7 1.2 1.0 -0.5 0.3
Miserableness 4.2 7.3 13.8 -2.0 -2.2 -3.1 1.8 -3.7 2.3 2.3 2.9 -3.3
Guilty feelings 3.7 5.6 14.1 -1.1 -1.3 -2.0 3.8 -2.8 2.4 2.4 1.9 -2.6
Wears glasses or contact lenses 0.5 0.6 1.5 -0.6 -0.7 -0.9 0.5 0.2 1.2 1.2 -0.0 -0.2
Ever taken oral contraceptive pill 0.4 0.5 1.4 0.6 -0.3 -0.3 0.5 -0.4 1.1 1.2 0.5 -0.7
Hearing aid user 0.3 0.4 0.9 0.5 -0.8 0.3 0.7 0.4 1.0 0.9 0.1 0.4
Mother’s age at death 0.3 0.3 0.9 0.1 -0.5 0.5 0.8 0.3 0.7 0.8 -0.9 0.3
Financial situation satisfaction 1.3 1.7 3.4 0.2 0.9 1.3 -1.3 1.2 -1.8 -1.7 -0.5 1.6
Tinnitus: Yes, now most or all of the time 2.6 3.0 10.4 1.5 2.1 2.1 -0.5 1.7 -0.3 -0.5 -3.2 1.6
Commuting to job workplace: Public transport 0.7 0.9 1.9 0.6 1.2 1.1 0.9 1.4 -0.5 -0.4 -0.5 1.2
Eye problems/disorders: Glaucoma 0.7 0.8 4.1 -0.4 -1.4 -0.5 2.0 -0.6 -0.4 -0.3 0.4 -0.5
Medication: Blood pressure 0.3 0.5 1.1 -0.9 0.8 -0.5 -0.8 -0.5 0.9 1.1 -0.2 -0.4
Pain type(s) experienced in last month: Hip pain 0.9 1.1 2.8 -1.7 0.2 -0.6 -0.1 -0.7 -1.7 -1.4 1.3 -0.3
Supplements: Fish oil (including cod liver oil) 3.9 5.1 10.2 1.6 3.2 2.9 -1.9 2.4 -1.5 -1.8 -1.8 2.6
High cholesterol (Self-reported) 0.4 0.7 1.3 -1.1 -0.6 -1.0 -1.1 -1.0 0.4 0.1 1.0 -0.8
Medication: Bendroflumethiazide 0.3 0.5 2.5 -1.6 0.2 -0.9 -0.9 -0.0 -0.5 -0.3 -0.1 0.1
Medication: Paracetamol 0.8 1.2 2.1 -0.6 -1.5 -1.1 1.1 -1.0 1.2 1.3 1.0 -1.1
Medication: Lisinopril 0.6 0.8 2.1 -0.6 -0.4 -1.2 -0.3 -0.8 1.3 1.5 -0.5 -0.8
Medication: Atorvastatin 1.2 1.5 3.2 -1.3 -0.6 -1.8 -0.3 -1.8 0.0 -0.1 1.7 -1.3
Illnesses of father: High blood pressure 0.1 0.1 0.2 0.3 -0.3 -0.3 -0.4 0.1 0.2 0.1 -0.5 0.2
Alcohol drinker status: Never 0.2 0.2 0.5 0.7 -0.6 -0.5 0.5 -0.4 0.4 0.4 -0.1 -0.7
Ever smoked 1.9 3.4 9.3 3.1 2.8 2.1 -1.2 1.8 0.7 0.5 -1.3 1.4
Basal metabolic rate 0.9 5.1 15.0 -2.4 -0.3 0.7 -0.4 2.0 -3.9 -3.7 -1.3 2.3
Leg fat percentage (left) 1.3 4.8 14.2 -3.8 -2.4 -2.9 0.3 -2.4 -0.5 -0.1 2.0 -2.2
Arm fat-free mass (left) 0.9 4.5 12.2 -2.5 -0.5 0.7 0.1 1.7 -3.5 -3.5 -1.3 2.1
Number of operations (self-reported) 0.7 1.1 3.0 -1.1 -1.5 -1.3 1.7 -0.6 0.2 0.6 0.6 -0.8
Average weekly beer plus cider intake 0.3 0.4 1.6 0.7 1.3 -0.0 -0.4 -0.6 0.3 0.3 -0.2 -0.8
Irritability 0.3 0.5 1.1 -0.7 0.3 -0.7 -0.1 -1.0 0.9 0.4 0.7 -0.9
Risk taking 1.8 2.7 3.9 0.9 1.6 1.6 -1.8 2.0 -1.2 -1.8 -1.7 1.9
Ever had prostate specific antigen (PSA) test 1.7 1.9 3.6 -1.2 -1.9 -1.7 -0.5 -1.2 1.4 1.2 1.5 -1.4
Fractured/broken bones in last 5 years 0.1 0.2 0.8 0.5 0.2 0.9 -0.0 0.3 -0.0 -0.4 -0.6 0.2
Age started oral contraceptive pill 1.5 1.8 3.5 1.9 1.4 1.7 -0.9 0.8 1.7 1.3 -1.4 0.4
Diastolic blood pressure, automated reading 0.2 0.5 1.7 -0.8 1.3 0.4 -1.2 0.5 -0.2 -0.2 -0.4 0.3
Ever depressed for a whole week 1.2 1.5 4.3 -0.9 0.0 0.3 2.1 -0.0 -1.9 -1.8 1.2 0.2
Unable to work because of sickness or disability 0.5 0.7 2.5 -0.6 -1.6 -0.9 1.2 -0.1 0.6 0.3 0.2 -0.6
Commuting to job workplace: Cycle 2.4 3.0 5.0 2.0 1.6 2.2 -1.2 1.9 -0.9 -1.1 -1.9 2.1
Myopia 1.8 2.6 4.9 0.5 1.9 1.6 -0.7 2.2 -1.2 -0.9 -2.2 2.1
Vascular/heart problems diagnosed by doctor 0.6 1.8 3.9 2.0 0.1 1.9 -0.4 1.4 -1.3 -1.5 -0.5 1.4
Cholesterol lowering medication 1.0 1.4 2.9 -1.7 -1.3 -1.5 0.2 -1.4 0.5 0.8 1.1 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.8 -1.4 -1.1 -1.2 0.2 -0.8 0.4 0.9 0.7 -0.8
Pain experienced in last month 1.5 2.5 7.3 2.7 1.7 1.6 -1.7 1.9 0.1 0.1 -0.8 1.5
Supplements: Calcium 0.4 0.4 1.1 -1.0 -0.5 0.1 -0.2 0.3 -0.9 -0.7 -0.5 0.7
Basal cell carcinoma (self-reported) 3.6 4.3 8.2 -0.6 -1.5 -2.1 1.5 -2.6 2.1 2.2 2.3 -2.9
Heart attack/myocardial infarction (self-reported) 1.6 2.1 5.5 -1.8 -0.8 -2.4 -0.4 -1.5 -0.2 0.1 2.2 -1.4
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 2.3 0.6 1.4 1.0 -0.8 1.1 -1.3 -1.5 -0.9 1.3
Heart disease (siblings) 0.6 0.7 2.0 0.8 0.3 -0.4 -0.6 -1.0 1.1 1.4 0.3 -1.1
Alcohol drinker status: Previous 3.5 4.0 6.2 -1.0 -1.2 -2.4 2.4 -2.2 1.8 2.1 1.6 -2.5
Pack years of smoking 2.2 3.3 5.0 -1.9 -1.9 -2.1 1.8 -2.2 0.6 0.6 2.2 -2.0
Impedance of whole body 0.5 2.4 9.1 3.0 1.5 0.2 1.1 -0.8 1.9 1.8 -0.2 -1.1
Leg fat mass (left) 0.9 3.4 15.2 -3.9 -1.9 -1.9 0.3 -0.9 -1.9 -1.5 1.1 -0.7
Arm predicted mass (left) 0.8 4.2 11.6 -2.7 -0.6 0.6 -0.1 1.5 -3.4 -3.4 -1.1 1.9