Hub : Genes

SPRY1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.179	0.0510	1.9e-04	0.017	NA	0.028	NA	0.030	1.4e-02	NA	2.0e-03	NA	1.6e-03
2	GTEx	Cells Transformed fibroblasts	0.110	0.0460	8.5e-03	-0.004	NA	-0.004	NA	-0.003	9.5e-01	NA	9.2e-01	NA	6.6e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.235	0.0502	3.7e-10	0.130	0.120	0.142	0.141	0.141	2.6e-16	3.6e-15	7.5e-18	1.1e-17	9.3e-18
4	TCGA	Esophageal Carcinoma	0.201	0.0950	4.9e-03	-0.004	0.048	0.013	NA	0.022	4.8e-01	1.2e-02	1.2e-01	NA	6.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.0	1.5	-0.9	-1.0	-1.0	-1.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	-0.6	-0.4	-0.4	0.7
Depressed Affect (Nagel 2018)	0.2	0.4	1.2	-1.1	-0.7	0.2	0.3
Depression (Nagel 2018)	1.2	1.8	4.4	1.4	-0.8	-0.4	-2.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	0.5	0.7	-0.6	0.5
Neuroticism (Nagel 2018)	0.2	0.4	1.5	0.4	-0.3	-1.2	-0.0
Schizophrenia (2018)	0.5	1.0	3.8	-0.1	0.3	0.3	1.9
Schizophrenia vs Biploar Disorder	0.8	1.1	3.4	-0.1	1.0	0.3	1.8
Worry (Nagel 2018)	0.7	1.5	2.9	1.6	0.6	-1.7	-0.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.7	-0.1	1.3	-0.9	0.3
Alzheimer’s Disease (in father)	2.5	2.7	5.3	0.9	2.2	0.2	2.3
Alzheimer’s Disease (including proxy)	1.4	2.0	5.7	0.5	2.4	-0.4	1.4
Crohns Disease (2017)	0.2	0.5	0.9	-0.9	-0.0	0.7	0.8
Irritable Bowel Disease (IBD)	0.8	2.0	5.7	0.6	1.4	0.3	2.4
Ulcerative Colitis (UC)	2.5	4.7	6.5	2.5	2.4	-0.5	2.6
Major Depression (MDD)	0.4	0.5	1.5	0.2	0.2	1.2	-0.6
Reaction Time	0.3	0.7	1.7	-1.3	-0.6	0.2	0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.2	0.3	0.0	0.5	0.5
Breast Cancer	0.5	1.1	4.0	-0.5	-0.5	-0.2	-2.0
Ovarian Cancer	0.5	0.7	2.5	0.0	0.5	1.6	-0.3
Prostate Cancer	0.9	1.3	4.2	2.0	0.8	0.3	-0.6
Age at First Birth	0.1	0.1	0.2	0.4	-0.4	0.3	-0.4
Bipolar Disorder (2011)	0.5	0.5	1.0	-0.6	-0.8	-0.3	1.0
Body Mass Index (BMI) (2010)	1.0	1.3	4.0	-1.0	-0.4	-2.0	0.2
Coronary Artery Disease (CAD)	1.4	1.7	3.3	1.8	-0.8	-0.1	-1.8
Crohns Disease (2012)	0.5	0.8	1.9	-0.9	0.4	1.4	0.5
Mean Putamen Volume	2.2	2.5	5.5	-0.8	-2.0	-0.0	-2.3
Fasting Glucose	0.3	0.4	1.1	-1.1	0.2	0.5	0.3
HbA1C	1.3	1.4	3.5	-1.2	0.8	1.9	0.4
HDL Cholesterol	1.0	1.7	4.1	-1.4	-0.5	2.0	0.7
LDL Cholesterol	0.4	0.7	1.6	-1.3	-0.6	-0.5	0.7
Lupus	2.2	3.3	8.0	-0.1	-2.1	-0.8	-2.8
Neuroticism (2016)	0.5	0.7	1.2	1.0	1.1	0.8	0.4
Primary Biliary Cirrhosis	0.7	1.1	3.0	1.7	0.9	0.6	0.3
Rheumatoid Arthritis	0.1	0.1	0.1	-0.1	0.4	-0.4	0.4
Schizophrenia (2014)	0.5	1.1	3.1	-0.8	0.7	-0.0	1.8
Triglycerides	0.3	0.5	0.9	0.5	-1.0	-1.0	0.2
Type 2 Diabetes (T2D) (2012)	1.7	2.0	4.4	2.1	-0.0	0.9	-1.7
Ulcerative Colitis	1.4	2.0	3.3	1.4	1.6	0.1	1.8
Blood Eosinophil Count	0.4	3.3	11.6	0.8	3.4	0.1	1.0
Blood Platelet Count	1.1	12.5	30.4	-5.5	-2.8	-3.3	1.0
Blood Red Count	0.3	2.6	5.5	1.2	1.9	0.1	2.3
Blood White Count	0.1	1.1	1.9	1.1	1.4	-1.0	-0.4
Heel T-Score	0.6	4.7	8.0	2.5	2.1	-0.5	-2.8
BMI	0.5	2.8	4.9	-1.5	-1.9	-2.2	0.6
Height	0.4	7.8	12.0	1.6	2.4	3.5	3.3
Waist Hip Ratio (WHR)	1.0	4.5	12.7	2.2	-0.7	0.1	-3.6
Systolic Blood Pressure	0.6	3.1	3.8	1.9	1.5	1.8	-1.9
Smoking Status	0.3	0.6	1.2	0.7	-0.9	-1.1	0.1
Allergy or Eczema	0.5	1.4	3.3	1.2	0.9	1.8	0.3
Cardiovascular Disease	0.1	0.4	1.2	0.2	0.1	0.3	-1.1
Hypothyroidism (self reported)	0.4	0.9	1.7	-1.0	-1.3	-0.6	0.6
Respiratory disease	0.4	0.8	2.4	-0.4	0.5	0.6	1.5
Type 2 Diabetes (T2D) (2018)	0.8	1.6	3.4	1.9	0.5	0.7	-1.4
Lung FEV1/FVC ratio	0.3	1.6	2.8	1.6	1.1	1.7	0.2
Lung FVC	0.5	2.3	4.3	2.1	-1.6	-0.3	-1.5
Neuroticism	0.0	0.1	0.2	-0.3	0.2	-0.2	0.4
Chronotype (morning person)	0.1	0.2	0.5	-0.4	0.1	-0.2	-0.7
Hair Pigment	0.1	1.7	6.3	0.5	2.5	-0.2	-0.5
Tanning	0.0	0.4	1.0	0.4	0.2	-0.8	1.0
Hand grip strength (left)	0.1	0.2	0.6	-0.8	-0.2	-0.4	0.5
Number of treatments/medications taken	0.2	0.3	0.6	0.8	0.3	0.2	-0.8
Average weekly spirits intake	0.5	0.6	1.4	1.2	0.2	-0.8	0.7
Sensitivity / hurt feelings	1.1	1.8	4.5	-1.2	-2.1	0.2	-1.2
Frequency of depressed mood in last 2 weeks	1.0	1.5	2.6	1.3	-0.9	0.9	-1.6
Hearing difficulty/problems: Yes	0.2	0.3	0.5	-0.3	-0.7	0.4	0.6
Relative age of first facial hair	1.0	2.0	5.6	-0.3	-1.1	-1.1	2.4
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.3	1.4	-1.5	-0.5	-1.1
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.3	-0.3	0.8	1.7	1.8
Ever had hysterectomy (womb removed)	1.8	2.0	4.9	2.2	1.8	0.1	-0.2
Systolic blood pressure, automated reading	0.2	0.5	1.2	0.3	0.8	0.4	-1.1
Eye problems/disorders: Diabetes related eye disease	2.1	2.4	7.2	1.0	0.9	-2.7	-0.7
Angina	0.9	1.2	1.8	1.3	-0.7	1.2	-1.0
Medication for hormone replacement therapy	0.2	0.2	0.5	-0.2	-0.0	0.4	0.7
Vitamin and mineral supplements	0.8	1.1	2.4	-1.2	-0.9	0.1	1.5
Supplements: Zinc	1.4	1.5	4.7	0.5	-2.2	-1.0	-0.3
Medication: Co-codamol	0.7	0.8	1.1	0.9	1.1	-0.2	-1.1
Medication: Metformin	1.0	1.4	4.9	0.5	-0.5	-0.6	-2.2
Diabetes (father)	0.7	0.9	1.7	0.3	-1.3	0.1	-1.3
Diabetes (mother)	0.2	0.2	0.4	0.5	0.6	-0.1	-0.4
Severe depression (siblings)	0.2	0.2	0.7	-0.8	0.3	0.3	0.2
Pack years adult smoking proportion	0.5	0.7	1.3	0.2	1.1	-0.5	1.1
Impedance of leg (right)	0.3	1.7	5.9	-0.6	0.1	-0.7	-2.4
Leg fat-free mass (left)	0.3	1.8	6.7	-0.7	-0.4	0.2	2.6
Trunk fat percentage	0.6	2.3	4.4	-2.1	-1.9	-0.4	-0.9
Hand grip strength (right)	0.1	0.2	0.6	-0.2	-0.6	0.2	0.8
Townsend deprivation index at recruitment	0.9	1.3	3.0	-1.7	-0.7	0.1	1.3
Current tobacco smoking	0.1	0.1	0.2	0.3	-0.4	-0.3	-0.4
Average weekly fortified wine intake	0.7	0.8	2.0	1.4	0.9	0.1	-0.4
Maternal smoking around birth	1.0	1.4	2.4	1.1	1.6	1.2	-0.8
Fed-up feelings	0.6	1.1	3.2	-1.8	-0.3	0.3	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	0.8	-0.3	-0.7	-0.3
Relative age voice broke	0.6	0.9	1.5	0.9	-0.3	-1.2	1.0
Taking other prescription medications	0.3	0.5	1.2	-0.4	-0.8	1.1	0.3
Age when periods started (menarche)	0.8	1.9	2.8	1.3	1.7	1.6	0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.5	-0.1	-1.6	0.1	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	8.9	0.8	0.2	-0.9	-3.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.5	-0.1	0.5	-1.2	1.2
Qualifications: CSEs or equivalent	0.5	0.7	2.2	-0.6	-0.0	-0.4	1.5
Serious illness, injury or assault to yourself	0.7	0.8	2.3	0.9	-1.5	0.3	0.1
High blood pressure	0.1	0.2	0.5	0.3	0.1	-0.7	0.2
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.1	1.0	1.1	1.4	0.7
Multivitamins +/- minerals	0.8	1.0	1.9	1.0	0.9	0.4	-1.4
Stomach or abdominal pain in last month	0.7	0.9	1.6	0.1	0.6	1.3	1.2
Supplements: Glucosamine	0.7	0.9	1.3	-0.7	-0.9	-1.1	-1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.6	-0.4	-1.3	0.1	-0.3
Medication: Atenolol	0.3	0.4	0.9	0.8	-1.0	0.5	0.1
Medication: Levothyroxine sodium	0.3	0.4	1.2	0.1	-0.8	0.1	1.1
Sitting height	0.6	4.5	5.5	1.7	2.2	2.4	2.2
Chronic bronchitis/emphysema (father)	0.3	0.4	0.9	-0.6	-0.3	0.2	1.0
High blood pressure (mother)	0.2	0.3	0.6	-0.6	0.7	0.2	-0.4
Body mass index (BMI)	0.4	1.9	4.2	-1.1	-2.0	-1.3	0.6
Impedance of leg (left)	0.3	1.5	5.9	-0.2	-0.0	0.3	-2.4
Leg predicted mass (left)	0.3	1.8	6.6	-0.7	-0.5	0.1	2.6
Trunk fat mass	0.4	1.9	4.3	-1.8	-2.1	-0.4	-0.2
Waist circumference	0.3	1.0	3.4	0.1	-1.8	-0.7	-0.3
Number of incorrect matches in round	1.3	2.2	4.6	0.4	-2.0	-0.4	-2.1
Past tobacco smoking	0.7	1.4	3.0	-0.8	1.7	1.3	-0.4
Alcohol usually taken with meals	0.4	0.7	2.3	1.5	-0.6	-0.1	0.1
Nervous feelings	0.2	0.3	0.5	-0.2	0.6	-0.6	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	0.8	-0.1	0.2	-1.1
Hearing difficulty/problems with background noise	0.3	0.5	1.3	-0.4	-1.1	0.6	-0.1
Hair/balding pattern: Pattern 2	2.0	2.6	6.6	2.6	1.6	0.5	-0.9
Had menopause	0.6	0.8	2.3	0.2	-0.1	1.5	0.8
Had other major operations	1.5	1.8	3.9	2.0	1.7	-0.6	0.4
Forced vital capacity (FVC)	0.2	0.8	2.0	1.4	0.1	1.0	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	4.0	0.3	0.3	-0.1	-2.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.7	-0.2	-0.6	-0.4
Qualifications: None of the above	0.6	1.2	2.3	-0.0	-1.3	-0.9	-1.5
Financial difficulties in last 2 years	0.3	0.5	0.8	0.8	0.1	-0.9	-0.6
Mouth/teeth dental problems	0.1	0.2	0.4	-0.5	0.6	0.3	-0.1
Heart attack	1.2	1.5	2.7	-1.1	-1.6	0.3	-1.5
Allergy	0.6	1.4	3.3	-0.2	-1.3	-0.8	-1.8
Pain all over the body in last month	0.6	0.6	2.3	0.2	-1.5	-0.1	-0.3
Diabetes (self-reported)	0.5	0.8	1.7	1.3	-0.1	-0.2	-1.3
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	4.0	-0.9	1.1	1.9	2.0
Medication: Ramipril	0.3	0.4	1.0	0.3	1.0	-0.7	-0.2
Medication: Simvastatin	0.4	0.6	1.4	-0.7	1.2	0.3	-0.8
Fluid intelligence score	0.1	0.2	0.7	0.9	-0.0	0.1	-0.3
Illnesses of siblings	0.3	0.5	0.9	0.9	0.4	-0.9	0.1
Neuroticism score	0.1	0.2	0.5	-0.5	0.2	-0.2	0.7
Weight	0.3	1.5	2.7	-1.1	-1.4	-0.1	1.6
Impedance of arm (right)	0.4	1.8	6.4	-0.2	-0.1	0.9	-2.5
Arm fat percentage (right)	0.6	2.3	6.9	-0.9	-2.6	-1.0	-0.8
Trunk fat-free mass	0.4	2.5	9.7	0.1	-0.2	-0.1	3.1
Hip circumference	0.3	1.4	3.0	-0.9	-1.4	0.3	1.7
Time employed in main current job	0.6	0.7	1.8	-1.3	0.4	-0.7	-0.7
Alcohol intake versus 10 years previously	1.7	2.6	6.7	-0.5	0.9	1.6	2.6
Father’s age at death	0.4	0.6	1.9	0.5	0.1	1.4	-0.4
Worrier / anxious feelings	0.2	0.5	1.5	-0.4	-0.4	-1.2	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	1.8	1.2	-1.1	-1.3	0.7
Falls in the last year	0.5	0.6	1.1	-1.1	-0.1	-1.1	-0.4
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	-0.0	0.0	0.3	-0.3
Number of live births	0.4	0.5	2.0	-0.2	0.3	0.1	1.4
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.6	1.2	0.1	1.6	0.5
Pulse rate	0.2	0.4	0.9	0.7	0.9	-0.4	0.1
Happiness	0.5	0.6	1.7	1.3	0.5	-0.5	0.2
Noisy workplace	2.0	2.5	4.8	-1.1	-2.2	1.6	-1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.7	1.3	0.8	-0.4	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	3.8	-1.9	1.1	0.2	0.6
Mouth/teeth dental problems: Dentures	0.7	1.2	1.8	-0.5	-1.1	1.3	-1.3
Asthma	0.6	1.2	3.4	-1.0	0.5	-0.0	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	-0.6	-0.2	-0.0	0.6
Medication: Cholesterol lowering	1.3	2.0	5.4	1.0	1.0	0.8	-2.3
Depression (self-reported)	0.1	0.1	0.2	-0.5	-0.1	0.3	0.3
Medication: Lansoprazole	0.2	0.2	0.5	0.4	-0.3	0.2	0.7
Prospective memory result	0.3	0.4	1.3	-0.5	-0.1	-1.1	0.3
Lung cancer (father)	0.5	0.6	1.0	-0.9	-0.4	-1.0	0.7
Illnesses of mother	1.8	2.2	5.5	-0.8	-2.4	-0.6	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.9	0.8	0.1	1.4	-0.0
Pulse wave Arterial Stiffness index	1.3	1.6	4.6	2.1	-1.2	-0.2	-0.1
Impedance of arm (left)	0.5	2.4	7.3	-0.6	0.3	1.3	-2.7
Arm fat mass (right)	0.4	1.5	3.9	-1.2	-2.0	-0.5	0.6
Trunk predicted mass	0.4	2.3	9.2	0.1	-0.3	-0.0	3.0
Standing height	0.4	3.6	6.9	-0.2	1.1	2.5	2.6
Length of working week for main job	1.0	1.1	3.8	0.4	0.2	-2.0	-0.5
Exposure to tobacco smoke at home	0.7	0.8	2.4	0.0	-0.8	-1.5	-0.1
Breastfed as a baby	0.7	0.8	2.6	0.2	-1.6	-0.7	-0.3
Tense / ‘highly strung’	2.1	3.4	5.2	2.0	1.9	-0.9	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.2	1.1	-0.1	-0.8	-1.0
Hair/balding pattern: Pattern 4	1.2	3.0	5.4	-0.2	1.5	-2.3	-2.1
Birth weight of first child	1.6	2.9	4.3	1.9	2.0	-0.0	2.1
Peak expiratory flow (PEF)	0.1	0.3	0.8	-0.3	-0.1	0.9	0.5
Pulse wave reflection index	0.9	1.1	2.4	0.7	-1.6	-0.0	-1.2
Ever highly irritable/argumentative for 2 days	1.5	1.7	4.3	0.2	-1.6	-0.4	-2.1
Loud music exposure frequency	0.4	0.5	0.8	-0.6	-0.9	-0.7	-0.6
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	3.7	1.9	1.0	-1.2	-1.9
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	4.9	1.4	-1.1	-2.2	0.4
Blood clot in the leg (DVT)	1.3	1.6	3.1	0.3	1.8	-0.9	1.6
Medication: Paracetamol	0.7	1.2	3.3	1.8	0.3	-1.0	-0.6
Headache pain in last month	0.2	0.4	0.7	-0.0	-0.7	-0.6	-0.8
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	1.8	-0.6	-1.3	-0.9	1.1
Glaucoma (self-reported)	0.3	0.4	0.8	-0.6	-0.2	0.9	0.5
Gout (self-reported)	2.4	3.3	7.0	-1.9	-2.6	-0.1	-1.5
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.7	-0.9	-1.6	-0.4	0.5
Medication: Amlodipine	0.8	1.1	2.4	1.2	0.5	1.5	-0.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.8	-0.9	0.8	0.1	0.7
Birth weight	0.6	1.2	2.4	0.4	0.7	-1.5	1.3
Chronic bronchitis/emphysema (mother)	1.5	1.7	4.5	0.4	2.1	1.5	0.1
High blood pressure (siblings)	0.6	0.9	2.2	-1.5	-1.0	0.3	-0.4
Forced vital capacity (FVC), Best measure	0.1	0.5	0.9	0.9	-0.0	1.0	-0.3
Body fat percentage	0.8	3.0	6.7	-1.9	-2.6	-0.8	-1.0
Leg fat percentage (right)	1.3	4.7	9.5	-2.2	-3.1	-2.1	-0.4
Arm fat-free mass (right)	0.5	2.5	9.4	-0.5	-0.1	0.3	3.1
Exposure to tobacco smoke outside home	1.4	1.9	4.0	0.7	-1.8	0.2	-2.0
Comparative body size at age 10	0.5	1.3	3.1	0.6	-0.5	-1.2	-1.8
Number of full brothers	0.6	0.7	1.0	-1.0	-0.7	-1.0	0.5
Worry too long after embarrassment	0.3	0.6	0.9	-0.9	-0.8	-0.8	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.3	0.6	-1.5	-1.1	-1.0
Wheeze or whistling in the chest in last year	1.8	3.1	6.6	-0.8	2.3	0.1	2.6
Number of children fathered	0.4	0.4	1.5	-0.4	-0.1	-1.2	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.2	1.5	0.7	-0.5	0.3
Age at first live birth	1.0	1.8	5.0	1.5	0.0	-0.4	-2.2
Pulse wave peak to peak time	1.2	1.4	4.0	-2.0	1.2	0.2	0.2
Health satisfaction	0.5	0.7	1.6	0.7	0.6	1.3	0.5
Shortness of breath walking on level ground	0.9	1.0	3.8	-0.1	-0.4	2.0	0.3
Qualifications: College or University degree	0.1	0.5	1.4	0.4	0.2	0.5	1.2
Eye problems/disorders: None of the above	0.9	1.0	2.3	0.5	-0.8	-1.0	-1.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.2	1.1	-0.3	-0.8	1.0
Emphysema/chronic bronchitis	0.8	0.9	2.0	0.9	1.4	0.1	0.9
Medication for pain relief, constipation, heartburn	0.7	1.3	4.3	-2.1	-0.8	0.4	-0.1
Neck or shoulder pain in last month	0.5	0.7	1.9	0.7	1.4	-0.6	0.2
Medication: Blood pressure	0.4	0.7	1.2	0.8	1.1	0.9	-0.4
Angina (self-reported)	1.1	1.4	2.3	1.5	-0.7	1.4	-0.9
Migraine (self-reported)	0.5	0.6	1.3	-1.1	-0.9	-0.1	-0.5
Medication: Ibuprofen	0.2	0.3	0.6	-0.6	0.2	0.0	0.8
Medication: Allopurinol	2.2	3.0	4.9	-1.8	-2.0	0.0	-2.2
Medication: Omeprazole	0.3	0.4	0.7	0.8	0.7	0.5	0.5
Medication: Seretide 50 evohaler	0.2	0.3	0.5	-0.6	-0.3	0.7	0.2
Mean time to correctly identify matches	0.9	1.6	2.7	-1.6	-1.2	0.5	1.4
Heart disease (mother)	1.6	2.0	4.1	-0.7	1.1	2.0	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.0	0.0	-0.0	0.3	-1.4
Whole body fat mass	0.6	2.4	6.7	-1.6	-2.6	-0.5	-0.1
Leg fat mass (right)	0.8	3.0	7.0	-1.6	-2.6	-1.6	0.2
Arm predicted mass (right)	0.5	2.5	9.5	-0.6	0.0	0.5	3.1
Pulse rate, automated reading	0.2	0.7	2.4	1.5	0.5	0.1	0.1
Alcohol intake frequency.	0.6	1.3	2.8	-1.7	-1.0	-1.1	0.3
Comparative height size at age 10	0.2	1.2	3.7	0.6	0.5	1.9	0.6
Number of full sisters	0.4	0.5	1.5	-1.2	-0.3	0.5	0.3
Suffer from ‘nerves’	0.9	1.5	2.9	1.7	0.5	-1.6	-0.3
Overall health rating	0.2	0.4	0.9	0.0	-0.9	0.8	-0.1
Chest pain or discomfort	0.8	1.2	2.8	-1.2	-0.5	0.4	1.7
Had major operations	2.3	2.8	10.4	3.2	0.6	-0.4	-0.4
Age at last live birth	1.0	1.5	5.3	0.5	-0.6	0.3	-2.3
Family relationship satisfaction	0.3	0.4	1.2	1.1	0.4	0.2	0.5
Leg pain on walking	0.7	0.8	1.6	-1.1	-0.2	0.6	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	5.1	-2.3	-1.6	0.1	-0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	-0.6	-0.8	-0.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.4	-0.3	0.6	0.4
Medication: Aspirin	0.7	0.9	2.2	1.5	0.5	-0.3	-1.0
Supplements: Vitamin C	0.4	0.4	1.3	1.2	0.4	-0.0	-0.5
Knee pain experienced in last month	0.5	0.7	2.6	0.0	0.0	1.6	0.4
Hypertension (Self-reported)	0.0	0.1	0.4	-0.2	-0.2	-0.7	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.2	0.2	-0.4	-0.3
Illnesses of father: Heart disease	0.4	0.6	1.6	-0.1	0.6	1.3	-0.7
Illnesses of siblings: Diabetes	1.1	1.4	3.9	-1.2	-0.4	2.0	-0.4
Smoking status: Previous	0.8	1.3	2.2	1.2	-1.0	-1.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.8	-0.9	-0.8	-0.8	-0.1
Whole body fat-free mass	0.4	2.5	9.8	-0.2	-0.2	0.2	3.1
Leg fat-free mass (right)	0.4	2.1	7.7	-0.3	-0.1	0.7	2.8
Arm fat percentage (left)	0.5	2.0	5.4	-1.1	-2.3	-0.8	-0.8
Average weekly red wine intake	0.7	1.0	2.4	1.6	-0.7	-0.9	-0.5
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.4	1.6	0.8	0.6	-0.5
Mood swings	0.2	0.3	0.5	-0.7	-0.4	0.4	0.7
Loneliness, isolation	1.3	1.8	3.8	-0.5	1.0	1.4	2.0
Long-standing illness, disability or infirmity	0.1	0.2	0.5	0.7	0.0	0.6	0.1
Ever had bowel cancer screening	0.6	0.7	2.6	-0.2	-0.3	-1.6	-0.3
Diabetes diagnosed by doctor	0.6	1.1	3.5	1.9	0.3	-0.1	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	3.5	-1.8	0.5	-0.4	1.9
Friendships satisfaction	0.7	0.8	1.5	1.0	-0.7	-1.2	-0.5
Qualifications: nursing, teaching	0.4	0.6	1.4	1.2	0.7	0.7	-0.3
Commuting to job workplace: Walk	0.5	0.6	1.1	1.0	0.9	-0.1	-0.5
Eye problems/disorders: Cataract	1.9	2.3	6.1	-0.8	0.2	1.5	2.5
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	5.8	1.2	1.1	-2.4	0.0
Medication for cholesterol	0.1	0.1	0.2	0.4	0.3	0.1	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.8	0.9	-0.4	-0.9	-0.5
Back pain experienced in last month	0.9	1.3	2.2	0.8	1.4	-0.5	1.5
Mineral and other dietary supplements	0.5	0.7	1.8	-0.4	-0.7	1.3	-0.5
Breast cancer (self-reported)	0.5	0.6	1.8	0.5	-0.2	-1.3	0.7
Asthma (self-reported)	0.7	1.5	4.2	-1.0	0.7	0.4	2.0
Osteoporosis (self-reported)	0.6	0.8	2.5	0.5	-1.6	-0.5	0.3
Osteoarthritis (self-reported)	1.4	1.8	4.3	0.8	1.5	2.1	0.4
Medication: Aspirin	0.8	1.0	2.2	1.3	0.5	-0.2	-1.5
Medication: Gliclazide	1.2	1.3	4.1	0.6	0.4	-0.9	-2.0
Illnesses of father: None of the above (group 1)	0.7	0.9	1.8	-0.1	-0.6	-1.2	-1.3
Smoking status: Current	0.1	0.1	0.3	0.2	-0.5	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	4.7	2.2	0.9	0.9	-1.2
Whole body water mass	0.4	2.5	9.8	-0.2	-0.2	0.4	3.1
Leg predicted mass (right)	0.4	2.2	7.8	-0.3	-0.2	0.9	2.8
Arm fat mass (left)	0.4	1.5	4.5	-1.1	-2.1	-0.6	0.1
Number of self-reported non-cancer illnesses	0.3	0.6	0.9	0.9	-0.8	-0.4	-0.9
Average weekly champagne plus white wine intake	0.2	0.3	0.7	-0.1	0.5	-0.8	-0.4
Miserableness	0.2	0.4	0.7	-0.8	-0.4	0.4	0.6
Guilty feelings	0.3	0.5	0.9	-0.5	0.2	-0.9	0.9
Wears glasses or contact lenses	0.9	1.0	2.2	0.1	1.5	0.8	1.1
Ever taken oral contraceptive pill	1.6	1.8	4.5	1.4	2.1	0.7	-0.0
Hearing aid user	0.7	0.8	1.8	0.3	0.6	1.3	-1.0
Mother’s age at death	0.3	0.3	0.6	-0.5	0.8	0.5	0.4
Financial situation satisfaction	0.4	0.5	0.7	0.8	0.8	-0.7	0.5
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.3	-1.5	-1.0	1.0	-1.0
Commuting to job workplace: Public transport	0.3	0.3	1.1	-1.0	0.2	0.2	-0.2
Eye problems/disorders: Glaucoma	0.9	1.1	3.3	-0.7	-0.2	1.8	0.6
Medication: Blood pressure	0.1	0.1	0.6	0.1	-0.0	-0.1	0.8
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.9	0.3	1.1	1.3	1.7
Supplements: Fish oil (including cod liver oil)	1.4	1.8	3.9	2.0	1.3	-1.1	-0.4
High cholesterol (Self-reported)	0.7	1.2	3.2	0.9	1.8	0.7	-0.2
Medication: Bendroflumethiazide	2.3	3.5	7.0	-1.0	1.1	2.2	2.6
Medication: Paracetamol	0.6	1.0	1.7	1.3	-0.2	-1.0	-1.1
Medication: Lisinopril	1.2	1.6	5.5	0.2	2.3	-0.5	0.6
Medication: Atorvastatin	1.7	2.1	7.2	2.7	-0.0	-0.3	-1.1
Illnesses of father: High blood pressure	0.4	0.5	1.0	-1.0	0.7	-0.7	0.1
Alcohol drinker status: Never	2.1	2.5	4.1	0.8	-1.4	-1.8	-2.0
Ever smoked	0.8	1.4	4.6	0.0	-2.2	-1.0	-0.1
Basal metabolic rate	0.4	2.1	7.8	-0.4	-0.5	0.1	2.8
Leg fat percentage (left)	1.0	3.7	8.8	-1.9	-3.0	-1.6	-0.2
Arm fat-free mass (left)	0.4	1.8	6.9	-0.3	-0.5	0.2	2.6
Number of operations (self-reported)	1.5	2.2	8.1	2.9	0.0	-0.8	0.0
Average weekly beer plus cider intake	0.3	0.4	1.0	-1.0	0.4	0.4	0.5
Irritability	0.0	0.0	0.1	0.0	-0.2	-0.2	0.1
Risk taking	0.1	0.1	0.3	0.2	-0.2	-0.5	0.4
Ever had prostate specific antigen (PSA) test	0.0	0.1	0.1	0.2	-0.4	-0.2	-0.1
Fractured/broken bones in last 5 years	0.5	0.7	1.2	0.4	-1.1	-0.4	-1.0
Age started oral contraceptive pill	3.0	3.7	11.4	1.7	3.4	0.6	0.3
Diastolic blood pressure, automated reading	0.8	2.4	5.5	-2.4	-1.1	1.5	0.7
Ever depressed for a whole week	0.4	0.5	1.2	0.6	-1.1	-0.6	-0.0
Unable to work because of sickness or disability	0.6	0.8	1.6	-0.5	-1.0	0.4	-1.3
Commuting to job workplace: Cycle	1.0	1.2	4.1	-2.0	-0.2	0.5	0.7
Myopia	0.5	0.7	1.4	-0.8	-0.8	-1.2	0.2
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	-0.2	0.5	0.6	0.3
Cholesterol lowering medication	0.1	0.1	0.4	0.0	0.4	0.2	0.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.6	1.1	0.3	0.7	1.3
Pain experienced in last month	0.2	0.4	0.6	-0.6	-0.8	-0.6	0.2
Supplements: Calcium	1.0	1.1	2.5	1.2	0.7	-1.6	0.1
Basal cell carcinoma (self-reported)	2.0	2.3	5.9	-1.5	-2.4	-0.5	0.9
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.3	-1.0	-1.8	0.1	-1.8
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.5	0.7	1.9	-0.7	1.4
Heart disease (siblings)	0.5	0.6	1.2	-0.8	-0.7	-1.1	0.1
Alcohol drinker status: Previous	0.7	0.8	2.5	-0.0	0.5	-1.6	0.6
Pack years of smoking	0.4	0.6	1.5	0.0	1.0	-0.3	1.2
Impedance of whole body	0.4	2.0	6.6	-0.7	0.6	0.7	-2.6
Leg fat mass (left)	0.6	2.5	6.8	-1.3	-2.6	-1.2	0.2
Arm predicted mass (left)	0.5	2.5	9.6	-0.4	-0.4	0.2	3.1